Syringe-based delivery devices for vascular access devices

Abstract

A delivery device for delivering an instrument into a catheter assembly may include a syringe having a barrel and a plunger movable within the barrel. In response to depression of the plunger within the barrel, the instrument may be advanced distally. The instrument may include a catheter, a probe, a light pipe for sterilization, or other suitable instrument. In response to depression of the plunger within the barrel, the distal end of the instrument may be moved through the catheter assembly coupled to the delivery device and into the patient's vascular system.

Description

[0001] Description of the case

[0002] The invention patent application is a divisional patent application. The original application of this divisional patent application (i.e.: Mother's case Firm Roll No. IIM211329 ), which is an invention patent application with an international application date of November 25, 2019, international application number PCT / US2019 / 063063, Chinese national application number 201980078454.1, and invention name “Syringe-based delivery device for vascular access device”. Background Art

[0003] Catheters are commonly used for various infusion therapies. For example, they can be used to administer fluids, such as saline solutions, various medications, and total parenteral nutrition, to patients. Catheters can also be used to withdraw blood from patients.

[0004] One common type of catheter is an over-the-needle peripheral intravenous ("IV") catheter. As the name suggests, an over-the-needle catheter can be mounted on an introducer needle with a sharp distal tip. The catheter and introducer needle can be assembled so that the distal tip of the introducer needle extends beyond the distal tip of the catheter, with the bevel of the needle pointing upward, away from the patient's skin. The catheter and introducer needle are typically inserted through the skin at a shallow angle into the patient's vasculature.

[0005] To verify proper placement of the introducer needle and / or catheter in the blood vessel, the clinician typically confirms the presence of a "flashback" of blood in the flashback chamber of the catheter assembly. Once needle placement is confirmed, the clinician can temporarily occlude flow in the vasculature and remove the needle, leaving the catheter in place for future blood draws or fluid infusions.

[0006] Drawing blood using a peripheral IV catheter can be difficult for several reasons, particularly when the catheter is in place for longer than a day. For example, when a catheter is inserted into a patient for an extended period, the catheter or vein may be more likely to narrow, collapse, kink, become clogged with debris (e.g., fibrin or platelet clots), and adhere the catheter tip to the vasculature. Consequently, catheters are typically used to collect blood samples while the catheter is in place, but are much less frequently used to collect blood samples while the catheter is in place. Consequently, when a blood sample is needed, an additional needle stick is required to provide venous access for blood collection, which can be painful for the patient and result in higher material costs. Therefore, there is a need for a catheter system and method that facilitates placement of blood sampling instruments, such as catheters and probes, within a patient's vasculature without the need for additional needle sticks.

[0007] The subject matter claimed herein is not limited to embodiments that solve any disadvantages or that operate only in environments such as those described above. Rather, this background is merely provided to illustrate one example technology area where some embodiments described herein may be practiced. Summary of the Invention

[0008] The present invention generally relates to a delivery device based on a syringe for delivering a vascular access device to a catheter assembly and / or a patient's vascular system, and related systems and methods. In certain embodiments, the delivery device can include a syringe, and the syringe has a tube and a plunger that can move in the tube. In certain embodiments, the delivery device can include a guide feature portion that can be arranged in the tube and / or be coupled to the plunger. In certain embodiments, the guide feature portion can move with the plunger. In certain embodiments, the guide feature portion can include a passage that can be roughly U-shaped. In certain embodiments, the guide feature portion and the passage can be oriented in various ways in the tube. For example, the passage can be oriented horizontally or vertically in the tube.

[0009] In some embodiments, the delivery device can include an instrument disposed within the barrel and extending through the guide feature. For example, the instrument can extend through the passageway. In some embodiments, in response to depression of the plunger or distal movement of the plunger, the guide feature can move distally a first distance, the instrument can move through the passageway, and the first end of the instrument can be advanced distally a second distance, which can be greater than the first distance. In some embodiments, the second distance can be at least twice the first distance.

[0010] In certain embodiments, in response to the plunger being partially and / or fully depressed in distal direction in the tube, the first end of the apparatus can be advanced to the distal end beyond the syringe in distal direction. In certain embodiments, the second end of the apparatus can be fixed. In certain embodiments, the second end of the apparatus can be fixed in the tube. In certain embodiments, the catheter adapter of the catheter assembly can be coupled to the syringe.

[0011] In some embodiments, the needleless connector can be arranged between the syringe and the catheter adapter, and the syringe can be connected to the catheter adapter. More specifically, in some embodiments, the distal end of the needleless connector can be coupled to the catheter adapter of the catheter assembly, and the proximal end of the needleless connector can be coupled to the syringe. In some embodiments, the distal end of the syringe can include a connector, which can be configured to be coupled to the proximal end of the catheter adapter and / or the needleless connector. In some embodiments, an interface adapter can be arranged between the syringe and the catheter adapter, and the syringe can be connected to the catheter adapter. In some embodiments, the second end of the instrument can be fixed in the interface adapter.

[0012] In certain embodiments, the tube can include a liquid, such as saline or another suitable flushing liquid. In certain embodiments, the liquid can be completely filled with the tube. In certain embodiments, in response to the depression of the plunger, the liquid can be discharged from the distal opening of the syringe. In certain embodiments, the diameter of the distal opening of the syringe can be larger than the outer diameter of the apparatus. In certain embodiments, in response to the depression of the plunger, the liquid can flow around the apparatus and flow into and / or flow through the catheter assembly.

[0013] In some embodiments, the barrel may not include liquid, but the syringe may be used to deliver the instrument to the catheter assembly. In these and other embodiments, the distal opening of the syringe may include a septum to form a seal between the distal opening of the syringe and the instrument, and the barrel or stopper may include a vent for allowing air to escape during advancement of the plunger.

[0014] In some embodiments, the apparatus can include a probe (which can include a sensor), a light tube for disinfection, or other suitable apparatus. In some embodiments, the apparatus can include a catheter. In these and other embodiments, the syringe can include an extension tube that can extend outward from the distal portion of the syringe. In some embodiments, the second end of the apparatus can be coupled to the extension tube. In some embodiments, blood collected from the patient can flow into the extension tube from the second end of the apparatus.

[0015] In certain embodiments, guide wire can be arranged in the instrument.In certain embodiments, in response to the plunger pressing down in the distal direction in the tube, guide wire and instrument can move through the passage.In certain embodiments, in response to the plunger pressing down in the distal direction in the tube, the first end of guide wire can be advanced in the distal direction.In certain embodiments, in response to the plunger pressing down, the guiding feature portion can move a first distance in the distal direction, and the first end of guide wire can be advanced a second distance in the distal direction.In certain embodiments, the second distance can be greater than the first distance.In certain embodiments, the second distance can be at least twice of the first distance.

[0016] In certain embodiments, in response to the plunger being partially and / or completely depressed, the first end of the guidewire can be advanced in a distal direction beyond the distal end of the syringe. In certain embodiments, the second end of the guidewire can be fixed. For example, the second end of the guidewire can be fixed in a barrel or an interface adapter.

[0017] In some embodiments, the delivery device can include a support tube that extends from and is coupled to the guide feature. In some embodiments, in response to depression of the plunger, the guide feature can be moved distally a first distance, the instrument can be moved through the support tube, the first end of the instrument can be advanced distally a second distance, and the first end of the support tube can be advanced distally the first distance. In these embodiments, the second distance can be greater than the first distance.

[0018] In certain embodiments, conveying device can allow instrument to access patient's vascular system by another vascular access device (for example, the catheter assembly that can insert patient's vascular system).In certain embodiments, when instrument was introduced in the catheter assembly by conveying device, instrument can access the fluid path and / or instrument of catheter assembly and can extend through catheter assembly and access patient's vascular system.In certain embodiments, catheter assembly can comprise catheter adapter and another conduit, and another conduit can extend distally from catheter adapter.In certain embodiments, the proximal end of another conduit can be fixed in the catheter adapter.

[0019] In certain embodiments, apparatus can be coupled to the plunger and can move to the advancement position along the plunger. In certain embodiments, apparatus can extend distally in the tube. In certain embodiments, the far-end of apparatus can be configured to advance distally toward the far-end of the syringe.

[0020] In some embodiments, the plunger may include a rib. In some embodiments, the instrument may be coupled to the rib and movable along the rib. In some embodiments, the plunger may include a slot. In these and other embodiments, the instrument may be disposed within the barrel and coupled to a propulsion tab movable along the slot. In some embodiments, the plunger may include a stopper. In some embodiments, in response to the plunger moving to the advanced position, the instrument may move through the stopper.

[0021] In some embodiments, the syringe may include an outer barrel, an inner barrel, an elongated body capable of moving within the inner barrel, and a plunger head disposed within the inner barrel. In some embodiments, the distal end of the elongated body may be coupled to the plunger head. In some embodiments, in response to the coupling of the elongated body and the plunger head, the elongated body and the plunger head may be configured to advance distally together to expel liquid from the inner barrel through the distal opening of the syringe.

[0022] In some embodiments, the instrument can extend from the distal end of the elongated body and through the plunger head. In some embodiments, in response to the elongated body being advanced in the distal direction within the inner barrel, the distal end of the instrument can be advanced in the distal direction. In some embodiments, in response to the elongated body being coupled to the plunger head, the elongated body and the plunger head can be configured to retract proximally together to expel liquid from the inner barrel into the outer barrel.

[0023] It should be understood that the summary description above and the detailed description below are examples and explanations, and are not limitations of the claimed invention. It should be understood that the various embodiments are not limited to the arrangements and means shown in the accompanying drawings. It should also be understood that these embodiments can be combined, or other embodiments can be utilized, and unless so desired, structural changes can be made without departing from the scope of the various embodiments of the present invention. Therefore, the detailed description below is not restrictive. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Example embodiments will be described and explained with additional specific detail through the use of the accompanying drawings, in which:

[0025] Figure 1A is a top view of an example delivery device coupled to an example catheter assembly, showing an example plunger of the delivery device in a proximal position, according to some embodiments;

[0026] Figure 1B is coupled to Figure 1A The catheter assembly Figure 1A a cross-sectional view of the delivery device showing the plunger in a proximal position;

[0027] Figure 1C According to some embodiments Figure 1A The conveyor device follows Figure 1A A cross-sectional view taken along line 1C-1C;

[0028] Figure 1D According to some embodiments Figure 1A The conveyor device follows Figure 1A Another cross-sectional view along line 1C-1C;

[0029] Figure 1E According to some embodiments Figure 1A a cross-sectional view of the distal end of an example catheter of a catheter assembly;

[0030] Figure 1F is a side view of another example delivery device coupled to a catheter assembly according to some embodiments, illustrating an example channel oriented vertically within an example barrel;

[0031] Figure 1G According to some embodiments Figure 1F A cross-sectional view of the delivery device showing a vertically oriented channel within the barrel;

[0032] Figure 1H According to some embodiments Figure 1F The conveyor device follows Figure 1F A cross-sectional view of line 1H-1H;

[0033] Figure 2Ais coupled to Figure 1A The catheter assembly Figure 1A An upper perspective view of the delivery device of , showing the plunger in a distal position;

[0034] Figure 2B is coupled to Figure 1A The catheter assembly Figure 1A a cross-sectional view of the delivery device showing the plunger in a distal position;

[0035] Figure 3A is a cross-sectional view of a delivery device having an example support tube according to some embodiments, showing the plunger of the delivery device in a proximal position;

[0036] Figure 3B According to some embodiments Figure 3A a cross-sectional view of the delivery device showing the plunger in a distal position;

[0037] Figure 4A is a cross-sectional view of another delivery device having an example instrument with a fixed end disposed in an example interface adapter, showing an example plunger of the delivery device in a proximal position, according to some embodiments;

[0038] Figure 4B According to some embodiments Figure 4A a cross-sectional view of the delivery device showing the plunger in a distal position;

[0039] Figure 5A is a schematic diagram of a support tube according to some embodiments. Figure 4A a cross-sectional view of the delivery device showing the plunger in a proximal position;

[0040] Figure 5B According to some embodiments Figure 5A a cross-sectional view of the delivery device showing the plunger in a distal position;

[0041] Figure 6A is an upper perspective view of another example delivery device according to some embodiments, showing an example plunger and an example instrument both in a proximal position;

[0042] Figure 6B is a diagram having example positioning features according to some embodiments. Figure 6A An upper perspective view of the delivery device of FIG, showing each of the instruments in a partially advanced position;

[0043] Figure 6C According to some embodiments Figure 6A The conveyor device follows Figure 6A A cross-sectional view taken along line 6C-6C;

[0044] Figure 6D According to some embodiments Figure 6A An upper perspective view of the delivery device showing the device in an advanced position;

[0045] Figure 6E According to some embodiments Figure 6A An upper perspective view of the delivery device of FIG, showing the instrument and plunger in a fully advanced position;

[0046] Figure 7A According to some embodiments Figure 6A an upper perspective view of a delivery device illustrating an example alternative instrument advancement mechanism;

[0047] Figure 7B According to some embodiments Figure 7A A cross-sectional view of a conveying device;

[0048] Figure 7C According to some embodiments Figure 7A a cross-sectional view of a delivery device showing the device in a partially advanced position;

[0049] Figure 8A is a cross-sectional view of another example delivery device according to some embodiments, illustrating an example elongated body in a proximal position;

[0050] Figure 8B According to some embodiments Figure 8A a cross-sectional view of a delivery device showing an elongated body distally advanced and coupled to an example plunger tip;

[0051] Figure 8C According to some embodiments Figure 8A a cross-sectional view of a delivery device showing the elongated body coupled to the plunger tip and the elongated body and plunger tip being advanced distally;

[0052] Figure 8D According to some embodiments Figure 8A a cross-sectional view of a delivery device showing the elongated body coupled to the plunger tip with the elongated body and plunger tip proximally retracted;

[0053] Figure 8E According to some embodiments Figure 8A another cross-sectional view of the delivery device showing the elongated body coupled to the plunger tip with the elongated body and plunger tip proximally retracted;

[0054] Figure 9A is a cross-sectional view of another example delivery device according to some embodiments, showing an example plunger in an initial position;

[0055] Figure 9B According to some embodiments Figure 9A a cross-sectional view of the delivery device showing the plunger in a partially advanced position;

[0056] Figure 9C According to some embodiments Figure 9A a cross-sectional view of the delivery device showing the plunger in a partially retracted position;

[0057] Figure 10A is a cross-sectional view of another example delivery device according to some embodiments, showing an example plunger in a proximal position;

[0058] Figure 10B According to some embodiments Figure 10A a cross-sectional view of the delivery device showing the plunger in a distal position;

[0059] Figure 10C According to some embodiments Figure 10A a cross-sectional view of a delivery device showing an example extension tube integrated into the plunger;

[0060] Figure 11 is a flowchart illustrating an example method according to some embodiments. DETAILED DESCRIPTION

[0061] Now refer to Figures 1A-1B In some embodiments, the delivery device 10 may include a syringe 12 having a barrel 14 and a plunger 16 movable within the barrel 14 . Figures 1A-1B The barrel 14 of the syringe 12 is shown in a proximal position according to some embodiments. In some embodiments, the delivery device 10 can include a guide feature 18 that can be disposed within the barrel 14 and / or coupled to the plunger 16. In some embodiments, the guide feature 18 can move with the plunger 16. In some embodiments, the guide feature 18 can include a channel 20 that can be generally U-shaped. In other embodiments, a portion 17 of the channel 20 can be removed, and the channel 20 can include a generally semicircular shape.

[0062] In some embodiments, the distal end of the plunger 16 may include a stopper 21, which may include rubber or other suitable materials. In some embodiments, the guide feature 18 may move with the plunger 16. For example, the guide feature 18 may be coupled to the stopper 21 and may move proximally and / or distally with the plunger 16. As another example, the stopper 21 may include a guide feature 18, and the guide feature 18 may move proximally and distally with the plunger 16. More specifically, in some embodiments, the channel 20 may be disposed within the stopper 21. In some embodiments, in response to the proximal movement of the plunger 16, the guide feature 18 may move proximally, and the instrument 22 may be retracted or withdrawn proximally.

[0063] In some embodiments, the delivery device 10 can include an instrument 22 that can be disposed within the barrel 14 and can extend through the guide feature 18. For example, the instrument can extend through the passage 20. In some embodiments, the instrument 22 can include a probe (which can include a sensor), a light pipe for sterilization, or other suitable instruments. In some embodiments, the instrument 22 can include a catheter. In these and other embodiments, the syringe 12 can include an extension tube 24 that extends outward from a distal portion of the syringe 12, such as the barrel 14. In some embodiments, the distal end of the barrel 14 can be proximal to the distal connector 34. In some embodiments, the barrel 14 can include a uniform inner diameter.

[0064] In some embodiments, the blood collection device 23 can be coupled to the extension tube 24. In some embodiments, the blood collection device 23 can include a vacuum tube, a test tube, or a syringe. In some embodiments, the blood collection device can include an adapter that can be configured to hold a test tube, such as Figures 1A-1B shown.

[0065] In some embodiments, in response to the plunger 16 being partially and / or fully depressed in the distal direction within the barrel 14, the first end 25 of the instrument 22 can be advanced in the distal direction beyond the distal opening 46 of the syringe 12. In some embodiments, the second end 28 of the instrument 22 can be fixed. In some embodiments, the second end 28 of the instrument 22 can be fixed within the barrel 14 or the distal connector 34. In some embodiments, the second end 28 of the instrument 22 can be coupled to the extension tube 24 so that blood collected from the patient via the catheter assembly 30 can flow from the second end 28 of the instrument 22 into the extension tube 24. In some embodiments, the first end 25 of the instrument 22 can be blunt and / or tapered.

[0066] In some embodiments, the catheter adapter 32 of the catheter assembly 30 can be coupled to the syringe 12. More specifically, in some embodiments, the distal end 26 of the syringe 12 can include a distal connector 34 that can be configured to couple to the proximal end of the catheter adapter 32. In some embodiments, the distal connector 34 can include a Luer adapter, such as a slip-on or threaded male or female Luer adapter, or another suitable connector.

[0067] In some embodiments, the needleless connector can connect the syringe 12 to the catheter adapter 32. More specifically, in some embodiments, the distal connector 34 can be configured to couple to the proximal end of the needleless connector. In some embodiments, the distal end of the needleless connector can couple to the proximal end of the catheter adapter 32. In some embodiments, the needleless connector can include a luer adapter, such as a male luer adapter or a female luer adapter, or any other suitable connector. In some embodiments, the needleless connector can include a temporary (pro re nata, "PRN") connector. In some embodiments, the needleless connector can include a SMARTSITE® connector available from Becton Dickinson. TM Needleless connector, Q-SYTE available from Becton Dickinson TM Luer-activated slit diaphragms, available from Baxter as INTERLINK TM A needle-free system or another suitable needle-free connector.

[0068] In some embodiments, catheter assembly 30 may include a catheter 36 that may be secured within catheter adapter 32 and may extend distally from catheter adapter 32. In some embodiments, catheter 36 may include a peripheral intravenous catheter that may be placed within the patient's vasculature. In some embodiments, catheter adapter 32 may be integrated, have an integrated extension tube (not shown), or be non-integrated.

[0069] In some embodiments, delivery device 10 can allow device 22 to access the patient's vasculature through catheter 36, which can be inserted into the patient's vasculature. In some embodiments, when device 22 is introduced into the catheter assembly via delivery device 10, the device can access the fluid path of catheter assembly 30 and / or the device 22 can extend through catheter assembly 30 and access the patient's vasculature.

[0070] In some embodiments, catheter assembly 30 can include a needle hub coupled to the proximal end of catheter adapter 32 and an introducer needle (not shown) extending distally from the needle hub. In some embodiments, the needle hub and introducer needle can be removed from catheter assembly 30 in response to placement of catheter 36 within the patient's vasculature, and after the needle hub and introducer needle are removed, delivery device 10 can be coupled to the proximal end of catheter adapter 32.

[0071] In some embodiments, guide feature 18 and channel 20 can be oriented in various ways and angles within barrel 14. For example, channel 20 can be oriented generally horizontally or vertically within barrel 14 when delivery device 10 is coupled with catheter adapter 32 positioned for insertion into a patient.

[0072] In some embodiments, the barrel 14 can include a liquid 38, such as saline or other suitable flushing liquid. In some embodiments, the liquid 38 can completely fill the barrel 14. In some embodiments, the liquid 38 can be used to flush all or a portion of the catheter assembly 30, as will be explained in further detail.

[0073] In some embodiments, a guidewire 40 can be disposed within the device 22. In some embodiments, in response to the plunger 16 being partially and / or fully depressed, the first end 42 of the guidewire 40 can be advanced in a distal direction beyond the distal end of the syringe 12. In some embodiments, the second end 44 of the guidewire 40 can be fixed. For example, the second end 44 of the guidewire 40 can be fixed within the barrel 14.

[0074] In some embodiments, the guidewire 40 can be used to facilitate placement of the device 22 within the patient's vasculature, which can result in less vein-related trauma. In some embodiments, the guidewire 40 can support the device 22, such as a catheter, during advancement to prevent it from being inserted into the second catheter (e.g., catheter 36, such as a catheter 36). Figures 1A-1B In some embodiments, the guidewire 40 can support the device 22 along all or a portion of the device 22 to improve structural reliability, provide adequate blood collection and fill time performance, maintain an acceptable risk of hemolysis, and minimize the risk of kinking the device 22. In some embodiments, after blood sampling is completed, the guidewire 40 and device 22 can be enclosed within the delivery device 10. It should be understood that in some embodiments, the delivery device 10 may not include a guidewire 40.

[0075] Now refer to Figure 1C, in some embodiments, the channel 20 can contact and support the instrument 22. In some embodiments, the shape of the channel 20 can be configured to reduce the risk of the instrument 22 kinking or bending as the instrument 22 moves through the channel. In some embodiments, the outer diameter of the guidewire 40 can be smaller than the inner diameter of the instrument 22 so that fluid can easily flow through the instrument 22. In some embodiments, the curvature of the U-shape can vary depending on, for example, the bend radius of the material comprising the instrument 22. In some embodiments, the curvature of the U-shape can be configured to prevent the instrument 22 from kinking or being damaged. In some embodiments, the channel 20 can include one or more protrusions 27, such as a lip or a detent, which can help to secure the instrument 22 within the channel 20.

[0076] Now refer to Figure 1D , as Figure 1C , where guide feature 18 only partially spans the lumen of barrel 14, in some embodiments, guide feature 18 may span the entire lumen of barrel 14. More specifically, in some embodiments, guide feature 18 may contact the entire interior surface of the barrel at a cross-section of the barrel, e.g., as shown in FIG. Figure 1D shown.

[0077] Now refer to Figures 1F-1H , in some embodiments, with e.g. Figures 1A-1B As opposed to the horizontal orientation shown, the passage 20 may be oriented vertically within the syringe 12, e.g. Figures 1F-1G In some embodiments, the guide feature 18 may span the entire lumen of the barrel 14 and contact the entire inner surface of the barrel at a cross-section of the barrel, for example, as shown in FIG. Figure 1H In other embodiments, guide feature 18 may only partially span the lumen of barrel 14 .

[0078] Now refer to Figures 2A-2B In some embodiments, the plunger 16 can be depressed or moved from a proximal position in a distal direction. In some embodiments, in response to depression of the plunger 16, the guide feature 18 can be moved in a distal direction a first distance, the instrument 22 can be moved through the channel 20, and the first end 25 of the instrument 22 can be advanced in a distal direction a second distance, which can be greater than the first distance. In some embodiments, due to the U-shape of the channel 20, the second distance can be at least twice the first distance (a "1:2 advancement ratio"). In some embodiments, the delivery device 10 and the 1:2 advancement ratio between the guide feature 18 and the first end 25 of the instrument 22 (or another advancement ratio in which the second distance is greater than the first distance) can provide reliability and structural support when the instrument 22 is advanced distally, while also providing an instrument 22 with a long reach.

[0079] In some embodiments, in response to depression of the plunger 16, the liquid 38 can exit the distal opening 46 of the syringe 12. In some embodiments, the diameter of the distal opening 46 of the syringe 12 can be larger than the outer diameter of the device 22. In some embodiments, in response to depression of the plunger 16, the liquid 38 can flow around the device 22 and into and / or through the catheter assembly 30.

[0080] In some embodiments, the apparatus 22 may include a guide wire 40 and / or a multi-diameter catheter, such as described in U.S. Patent Application No. 62 / 660,646, filed April 20, 2018, entitled "MULTI-DIAMETER CATHETER AND RELATED DEVICES AND METHODS," which is incorporated herein by reference. In some embodiments, the multi-diameter catheter can allow for increased blood flow rates during blood collection. In some embodiments, the distal end of the guide wire 40 can be disposed proximal to a transition portion of the multi-diameter catheter to allow fluid to flow in an annular space between the outer surface of the guide wire 40 and the inner surface of the multi-diameter catheter.

[0081] In some embodiments, in response to the plunger 16 being depressed in the distal direction within the barrel 14, the guidewire 40 can move through the channel 20 within the instrument 22, and the first end 42 of the guidewire 40 can be advanced in the distal direction. In some embodiments, in response to the plunger 16 being depressed, the guide feature 18 can move in the distal direction a first distance, and the first end 42 of the guidewire 40 can be advanced in the distal direction a second distance. In some embodiments, the second distance can be greater than the first distance. In some embodiments, the second distance can be at least twice the first distance.

[0082] Return Reference Figure 1E In some embodiments, the distal end 48 of the conduit 36 ​​can include one or more flow holes 50 extending through the wall of the conduit 36. In some embodiments, the liquid 38 can flow out of the flow holes 50 in response to the plunger 16 being depressed.

[0083] Now refer to Figures 3A-3B In some embodiments, the delivery device 10 can include a support tube 54 that extends from the guide feature 18. In some embodiments, the support tube 54 can be fixed to the guide feature 18. In some embodiments, in response to depression of the plunger 16, the guide feature 18 can be moved distally a first distance, the instrument 22 can be moved through the support tube 54, and the first end 56 of the support tube 54 can be advanced distally a first distance. In some embodiments, the support tube 54 can include a uniform inner diameter and / or uniform outer diameter along all or a portion of the length of the support tube 54.

[0084] In some embodiments, when the delivery device 10 includes a support tube 54, the device 22 can include a catheter constructed of a material softer than polyimide, which is less traumatic to the vein wall. In these and other embodiments, the device 22 can include a tube constructed of one or more of polyurethane, silicone, a thermoplastic elastomer ("TPE"), a thermoplastic polyurethane ("TPU"), and another suitable compliant material.

[0085] In some embodiments, the support tube 54 can include an inner diameter that is larger than the outer diameter of the instrument 22 so that the instrument 22 can be easily moved through the support tube 54. In some embodiments, the support tube 54 can provide support for the first end 25 or free end of the instrument 22. In some embodiments, in response to depression of the plunger 16 and movement of the guide feature 18 a first distance, the first end 56 of the support tube 54 can be advanced distally a distance equal to the first distance (a "1:1 advancement ratio"), while the first end 25 of the instrument 22 can be advanced a distance greater than the first distance, for example, twice the first distance (a "1:2 advancement ratio"). In some embodiments, the different advancement ratios of the guide feature 18 relative to the first end 25 and the guide feature 18 relative to the support tube 54 can result in the support tube 54 not being advanced distally beyond a portion of the instrument 22, and the portion of the instrument 22 being advanced distally through the catheter assembly 30 and into the vasculature. In these and other embodiments, the portion of the instrument 22 can have a reduced outer diameter, or the instrument 22 can include a uniform diameter along all or part of the length of the instrument 22.

[0086] In some embodiments, given a 1:2 advancement ratio between guide feature 18 and first end 25 of instrument 22 (or another advancement ratio where the second distance is greater than the first distance) and a 1:1 advancement ratio between guide feature 18 and first end 56 of support tube 54, first end 25 of instrument 22 can exit first end 56 of support tube 54. In some embodiments, first end 25 of instrument 22 can exit first end 56 of support tube 54 to facilitate entry of instrument 22 into a portion of catheter assembly 30 that may be too narrow for support tube 54 to enter.

[0087] In some embodiments, the delivery device 10 can facilitate timed or delayed removal of the instrument 22 from the support tube 54. More specifically, in some embodiments, the first end 25 of the instrument 22 can be shortened so that when the guide feature 18 is fully retracted, the first end 25 of the instrument 22 is positioned flush with or proximal to the first end 56 of the support tube 54, e.g., Figure 3A shown.

[0088] Now refer to Figures 4A-4B, according to some embodiments, another delivery device 58 is shown. In some embodiments, the delivery device 58 can include or correspond to the delivery device 10 discussed with respect to FIGs. 1-3 . More specifically, in some embodiments, the delivery device 58 can include one or more features of the delivery device 10, and / or the delivery device 10 can include one or more features of the delivery device 58.

[0089] In some embodiments, the second end 28 of the device 22 can be secured within an interface adapter 60, which can connect the delivery device 58 to the proximal end of a needleless connector or a proximal end of a catheter adapter (e.g., the catheter adapter 32 discussed with respect to Figures 1-3). In some embodiments, the needleless connector can be disposed between the interface adapter 60 and the catheter adapter and can connect the interface adapter 60 to the catheter adapter. In some embodiments, the proximal end 62 of the interface adapter 60 can be configured to couple with the distal connector 34 of the delivery device 58. In some embodiments, the proximal end 62 can include a luer adapter, such as a sliding or threaded male or female luer adapter, or another suitable connector. In some embodiments, the proximal end 62 of the interface adapter 60 can be removably or non-removably coupled to the distal connector 34. In some embodiments, the distal end 63 of the interface adapter 60 can include a luer adapter, such as a sliding or threaded male or female luer adapter, or another suitable connector that can be configured to couple with the proximal end of the needleless connector or the proximal end of the catheter adapter.

[0090] In some embodiments, the interface adapter 60 may include a side port 64, which may include a luer adapter, such as a sliding or threaded male or female luer adapter, or another suitable connector. In some embodiments, the delivery device 58 may include a first cap and / or a second cap (not shown). In some embodiments, when the plunger 16 is in the proximal position, the instrument 22 is completely contained within the syringe 12, and the first cap can be coupled to and seal the distal opening 46 of the syringe 12. In some embodiments, the first end of the instrument 22 is fixed within the interface adapter 60, and the first cap can be coupled to and seal the distal end of the interface adapter 60. In some embodiments, the second cap can seal the side port 64. In some embodiments, for example, the first cap can be removable to allow the delivery device 58 to be connected to the interface adapter 60, and / or the second cap can be removable to allow a blood collection device to be coupled to the side port 64.

[0091] In some embodiments, a blood collection device, e.g. Figures 1A-1BThe blood collection device 23 of the embodiment of the present invention can be coupled to the Luer adapter of the side port 64 to collect blood from the patient. In some embodiments, the blood collection device can include a syringe, a blood collection tube, or another suitable device. In some embodiments, the extension tube 24 can be coupled to the side port 64 and can extend from the side port 64. In some embodiments, the proximal end of the extension tube 24 can be coupled to the blood collection device.

[0092] In some embodiments, the side port 64 may include a lumen 66 that can be sealed from the lumen 68 of the interface adapter 60, which can prevent blood or other fluids from leaking into the lumen 68. In some embodiments, the lumen 66 can be sealed from the lumen 68 by a wall 70, and the second end 28 of the instrument 22 and / or the second end 44 of the guidewire 40 (not shown) can be sealed from the lumen 68. Figures 4A-4B ) may extend through the wall 70. In some embodiments, for example, Figures 1A-1C The guidewire 40 shown in Figures 2A-2B can be disposed within the device 22 and can be positioned in a manner similar to that described with respect to Figures 1A-1C Operate in the manner discussed in 2A-2B.

[0093] Now refer to Figures 5A-5B In some embodiments, the delivery device 58 can include a support tube 54 that can extend from the guide feature 18. In some embodiments, the support tube 54 can be fixed to the guide feature 18. In some embodiments, in response to depression of the plunger 16, for example, Figure 5B As shown, guide feature 18 can be moved a first distance in a distal direction, instrument 22 can be moved through support tube 54, and first end 56 of support tube 54 can be advanced a first distance in a distal direction. In some embodiments, support tube 54 can include a uniform inner diameter and / or uniform outer diameter along the entire length of support tube 54.

[0094] Now refer to Figures 6A-6E , another example delivery device 72 is shown, according to some embodiments. In some embodiments, the delivery device 72 may include or correspond to the delivery device 10 discussed with respect to FIGs. 1-3 and / or the delivery device 58 discussed with respect to FIGs. 4-5 . More specifically, in some embodiments, the delivery device 72 may include one or more features of the delivery device 10 and / or the delivery device 58. In some embodiments, the delivery device 10 and / or the delivery device 58 may include one or more features of the delivery device 72.

[0095] In some embodiments, the instrument 22 can be coupled to the plunger 16 and can be moved distally along the plunger 16 to an advanced position. In some embodiments, the instrument 22 can also be moved proximally along the plunger 16 to retract the instrument 22. In these and other embodiments, the instrument 22 can be moved independently of the plunger. In some embodiments, the instrument 22 can extend distally into the barrel 14. In some embodiments, the distal end 74 of the instrument 22 can be configured to be advanced distally of the distal opening 46 of the syringe 12, for example, as shown in FIG. Figures 6D-6E shown.

[0096] In some embodiments, the plunger 16 can include at least one rib 76. In some embodiments, the instrument 22 can be coupled to the rib 76 and can move along the rib 76. In some embodiments, the instrument 22 can be coupled to the rib 76 via a push tab 81 that can extend over the rib 76, for example, as shown in FIG. Figure 6C In some embodiments, the plunger 16 may include a stopper 78 that may include rubber or other suitable materials. In some embodiments, in response to the plunger 16 moving to the advanced position, the instrument 22 may move through the stopper 78.

[0097] like Figure 6B As shown, in some embodiments, a positioning feature 80 can include a proximal end coupled to a push tab 81, which can be coupled to the instrument 22 and configured to move the instrument 22 proximally and / or distally. In some embodiments, the positioning feature 80 can be rigid. In some embodiments, the distal end 82 of the positioning feature 80 can contact the upper surface of the syringe 12 to prevent distal movement of the push tab 81 and the instrument 22. In some embodiments, the distal end 82 of the positioning feature 80 can be free-floating and can contact the upper surface of the syringe 12 in response to distal movement of the push tab 81 and the instrument 22. In some embodiments, the distal end 82 of the positioning feature 80 can be attached to or selectively attached to the syringe 12. In some embodiments, the positioning feature 80 can secure the position of the instrument 22 when the delivery device 72 is packaged and / or prior to use.

[0098] In some embodiments, in response to depression of the plunger 16, the liquid 38 can flow out of the distal opening 46 of the syringe 12. In some embodiments, the distal end 26 of the syringe 12 can include a Luer adapter, such as a slip-on or threaded male or female Luer adapter, or another suitable connector. In some embodiments, the syringe 12 can be coupled to the proximal end of the catheter adapter 32 of the catheter assembly 30 (e.g., at Figures 1A-1B and 2A-2B ), and the instrument 22 can be advanced in a distal direction such that the instrument 22 is disposed in the fluid path of the catheter assembly 30 and / or is advanced beyond the distal end 48 of the catheter 36.

[0099] In some embodiments, a method of operating the delivery device 72 may include coupling the delivery device 72 to the proximal end of the catheter adapter 32, which may include an indwelling catheter 36. In some embodiments, the device 22 may then be advanced in a distal direction. In some embodiments, the plunger 16 may be depressed, causing the fluid 38 to flow around the device 22 and through the catheter 36 to flush the catheter 36 and the catheter assembly 30.

[0100] In some embodiments, the barrel 14 and / or plunger 16 may include one or more markings 19 that can provide a visual and / or tactile indication of the position of the instrument to the user. More specifically, in some embodiments, the markings 19 can indicate the distance the instrument 22 has been advanced and / or retracted. In some embodiments, the barrel 14 and / or plunger 16 can be transparent. It should be understood that other embodiments of the barrel 14 and / or plunger 16 may include markings.

[0101] Now refer to Figures 7A-7C In some embodiments, the plunger 16 of the delivery device 72 can include a slot 84. In these and other embodiments, the instrument 22 can be disposed within the barrel 14 and coupled to a push tab 86 that can move along the slot 84. In some embodiments, the push tab 86 can be coupled to the instrument 22 and configured to move the instrument 22 proximally and / or distally.

[0102] Now refer to Figures 8A-8E , another example delivery device 88 is shown, according to some embodiments. In some embodiments, delivery device 88 may include or correspond to one or more of the following: delivery device 10 discussed with respect to Figures 1-3; delivery device 58 discussed with respect to Figures 4-5; and delivery device 72 discussed with respect to Figures 6-7. More specifically, in some embodiments, delivery device 88 may include one or more features of one or more of the following: delivery device 10, delivery device 58, and delivery device 72. In some embodiments, one or more of the following may include one or more features of delivery device 88: delivery device 10, delivery device 58, and delivery device 72.

[0103] In some embodiments, the syringe 12 may include an outer barrel 90, an inner barrel 92, an elongated body 94 movable within the inner barrel 92, and a plunger head 96 disposed within the inner barrel 92. In some embodiments, the elongated body 94 may be moved from, for example, Figure 8A The proximal position shown is advanced in the distal direction and the distal end 98 of the elongated body 94 can be coupled to the plunger head 96, e.g. Figure 8BIn some embodiments, in response to the elongated body 94 being advanced in the distal direction from the proximal position to couple to the plunger head 96, some of the liquid 38 can be expelled from the inner barrel 92. In some embodiments, in response to the elongated body 94 being coupled to the plunger head 96, the elongated body 94 and the plunger head 96 can be configured to be advanced distally together to expel the liquid 38 from the inner barrel 92 through the distal opening 46 of the syringe 12, for example, as shown. Figure 8C In some embodiments, when the elongated body 94 and the plunger head 96 are coupled together, they can form a unitary plunger 16 .

[0104] In some embodiments, the instrument 22 can extend from the distal end 98 of the elongated body 94 and through the plunger head 96. In some embodiments, in response to the elongated body 94 being advanced in the distal direction within the inner barrel 92, the distal end 74 of the instrument 22 can be advanced in the distal direction. In some embodiments, in response to the elongated body 94 being coupled to the plunger head 96, the elongated body 94 and the plunger head 96 can be configured to retract proximally together to expel the liquid 38 from the inner barrel 92 into the outer barrel 90, for example, as Figure 8D In some embodiments, the elongated body 94 can be coupled to the plunger head 96 in various ways, such as snap fit, interference fit, thread, barb fit, etc. For example, Figures 8A-8D Barb fit is shown.

[0105] In some embodiments, one or more one-way valves 100 can be disposed between the inner barrel 92 and the outer barrel 90, and in response to retraction of the coupled elongated body 94 and plunger head 96, the liquid 38 can flow from the inner barrel 92 to the outer barrel 90 through the one-way valves. In some embodiments, the distal end of the inner barrel 92 and / or the distal end of the outer barrel 90 can include a septum 93. In some embodiments, the delivery device 88 can include a vent element to prevent the formation of a vacuum when the plunger is retracted proximally. In some embodiments, the vent element can provide ventilation to the portion of the inner barrel 92 distal to the plunger head 96 and can prevent the formation of a vacuum when the elongated body 94 and the plunger head 96 are retracted proximally.

[0106] In some embodiments, the proximal end of outer barrel 90 can include a seal 97 proximate an opening in outer barrel 90 through which elongated body 94 can extend. In some embodiments, seal 97 can prevent fluid from leaking from the proximal end of outer barrel 90.

[0107] In some embodiments, the outer barrel 90 can include multiple parts that can be coupled together. More specifically, in some embodiments, the outer barrel 90 can include a first part and a second part that can be coupled together via welding, adhesive, pins, press fit, or other suitable means. In some embodiments, the outer barrel 90 can be integrally formed as a single unit.

[0108] In some embodiments, the inner barrel 92 can be secured within the outer barrel 90 via one or more retention features. More specifically, in some embodiments, the one or more retention features of the inner barrel 92 can mechanically mate (e.g., a snap fit, a press fit, or other suitable fit) with one or more retention features of the outer barrel 90. In some embodiments, the retention features can include ribs 99 extending from the inner barrel 92 to the outer barrel 90. Example ribs 99 are Figures 8A-8D . In some embodiments, ribs 99 can be rigid or semi-rigid. In some embodiments, the retention feature can be annular and can extend around the circumference of inner barrel 92. In these and other embodiments, the retention feature can include holes and / or valves that can open in response to fluid pressure to allow fluid to pass through. In some embodiments, fluid can flow around the retention feature.

[0109] As described above, in some embodiments, the elongated body 94 can be coupled to the plunger head 96 in various ways, such as a snap fit, an interference fit, threads, a barb fit, etc. Figure 8E Each of the elongated body 94 and the plunger head 96 is shown including one or more threads, according to some embodiments. In some embodiments, the elongated body 94 is threadedly coupled to the plunger head 96. In some embodiments, after a user has threadedly coupled the elongated body 94 to the plunger head 96, the elongated body 94 and the plunger head 96 can be advanced distally together to expel the liquid 38 from the inner barrel 92 through the distal opening 46 of the syringe 12 and advance the instrument 22. In some embodiments, in response to the elongated body 94 being threadedly coupled to the plunger head 96, the elongated body 94 and the plunger head 96 can be configured to retract proximally together to expel the liquid 38 from the inner barrel 92 into the outer barrel 90 and retract the instrument 22. In some embodiments, in response to the elongated body 94 and the plunger head 96 being partially or completely retracted in a proximal direction, the user can unscrew the elongated body 94 from the plunger head 96, allowing the elongated body 94 and the instrument 22 to be removed from the delivery device 88.

[0110] Now refer to Figures 9A-9C, another delivery device 102 is shown, according to some embodiments. In some embodiments, the delivery device 102 may include or correspond to one or more of the following: the delivery device 10 discussed with respect to Figures 1-3; the delivery device 58 discussed with respect to Figures 4-5; the delivery device 72 discussed with respect to Figures 6-7; and the delivery device 88 discussed with respect to Figure 8. More specifically, in some embodiments, the delivery device 102 may include one or more features of one or more of the following: the delivery device 10, the delivery device 58, the delivery device 72, and the delivery device 88. In some embodiments, one or more of the following may include one or more features of the delivery device 102: the delivery device 10, the delivery device 58, the delivery device 72, and the delivery device 88.

[0111] In some embodiments, the syringe 12 of the delivery device 102 may include an outer barrel 104, an inner barrel 106 containing a liquid 38 and movable between a proximal position and a distal position within the outer barrel 104, a plunger 16 capable of being pressed within the inner barrel 106, and a first valve 108 disposed between the outer barrel 104 and the inner barrel 106. In some embodiments, the inner barrel 106 may be pre-filled with the liquid 38, e.g., Figure 9A shown. Figure 9A The delivery device 102 is shown in an initial position or when removed from packaging, according to some embodiments.

[0112] In some embodiments, the plunger 16 may include a second valve 110 configured to allow the liquid 38 to flow from the inner barrel 106 to the outer barrel 104 in a distal direction in response to depression of the plunger 16 within the inner barrel 106, for example Figure 9B In some embodiments, when the inner barrel 106 is in the distal position and during the depression of the plunger 16, the first valve 108 can be closed, for example, Figure 9B In some embodiments, in response to the plunger 16 being retracted in the proximal direction, the first valve 108 can open and the liquid 38 can flow through the distal opening 46 of the syringe 12, for example, as Figure 9C In some embodiments, the delivery device 102 may include a plurality of first valves 108 and / or a plurality of second valves 110, for example Figure 9A shown.

[0113] In some embodiments, the instrument 22 can extend through the plunger 16. In some embodiments, in response to the depression of the plunger 16, the distal end 74 of the instrument 22 can be advanced in the distal direction. In some embodiments, the distal end 26 of the syringe 12 can include a distal connector 34, such as a sliding or threaded male or female Luer adapter, or another suitable connector. In some embodiments, the distal end 74 of the instrument 22 can be blunt and / or tapered. In some embodiments, the distal connector 34 can be configured to be coupled to the proximal end of a catheter adapter. In some embodiments, the syringe 12 can be coupled to the proximal end of the catheter adapter 32 of the catheter assembly 30 (e.g., at Figures 1A-1B and 2A-2B ), and the plunger 16 can be depressed to advance the instrument 22 in a distal direction such that the instrument 22 is disposed in the fluid path of the catheter assembly 30 and / or is advanced beyond the distal end 48 of the catheter 36.

[0114] In some embodiments, a method of operating the delivery device 102 may include coupling the delivery device 102 to the proximal end of the catheter adapter 32. In some embodiments, the plunger 16 may be depressed to advance the instrument 22 in a distal direction, which may also cause the liquid 38 to flow from the inner barrel 106 through the first valve 108 into the outer barrel 104. In some embodiments, depressing the plunger 16 may also move the inner barrel 106 to a distal position, closing the second valve 110. In some embodiments, the plunger 16 may then be retracted or moved proximally, causing the instrument 22 to at least partially retract in a proximal direction. In some embodiments, the proximal movement of the plunger 16 may also move the inner barrel 106 proximally, thereby opening the second valve 110. In some embodiments, when the plunger is moved proximally, the liquid 38 disposed within the outer barrel 104 may exit the distal opening 46 of the syringe 12 and may flush the catheter assembly 30.

[0115] In some embodiments, the inner surface of the outer barrel 104 can include a stop or lock that can prevent the inner barrel 106 from moving proximally beyond the proximal position. In some embodiments, the proximal end of the outer barrel 104 can include a seal 97 proximate an opening in the outer barrel 104 through which the plunger 16 can extend. In some embodiments, the seal 97 can prevent fluid from leaking from the proximal end of the outer barrel 194.

[0116] In some embodiments, the inner barrel 106 can be secured within the outer barrel 104 via one or more retention features. More specifically, in some embodiments, the one or more retention features of the inner barrel 106 can mechanically mate (e.g., snap fit, press fit, or other suitable fit) with one or more retention features of the outer barrel 104. In some embodiments, the retention features can include one or more ribs 99 (e.g., at Figures 8A-8D104 ), which can extend from the inner barrel 106 to the outer barrel 104. In some embodiments, the ribs 99 can be rigid or semi-rigid. In some embodiments, the retention feature can be annular and can extend around the circumference of the inner barrel 106. In these and other embodiments, the retention feature can include holes and / or valves that can open in response to fluid pressure to allow fluid to pass through. In some embodiments, the fluid can flow around the retention feature.

[0117] In some embodiments, the proximal end of the inner barrel 106 can include one or more retention features 111. In some embodiments, the proximal end of the inner barrel 106 can include a single annular retention feature 111. In some embodiments, the retention feature 111 can contact the plunger 16 to prevent proximal movement of the plunger 16. In some embodiments, the distal opening 46 can include an anti-backflow valve that can prevent blood from flowing back into the delivery device 102.

[0118] Now refer to Figures 10A-10B , another example delivery device 112 is shown, according to some embodiments. In some embodiments, the delivery device 112 may include or correspond to one or more of the following: the delivery device 10 discussed with respect to Figures 1-3; the delivery device 58 discussed with respect to Figures 4-5; the delivery device 72 discussed with respect to Figures 6-7; the delivery device 88 discussed with respect to Figure 8; and the delivery device 102 discussed with respect to Figure 9. More specifically, in some embodiments, the delivery device 112 may include one or more features of one or more of the following: the delivery device 10, the delivery device 58, the delivery device 72, the delivery device 88, and the delivery device 102. In some embodiments, one or more of the following may include one or more features of the delivery device 112: the delivery device 10, the delivery device 58, the delivery device 72, the delivery device 88, and the delivery device 102.

[0119] In some embodiments, the plunger 16 can include a connector 114. In some embodiments, the connector 114 can include a luer adapter, such as a slip-on or threaded male or female luer adapter, or another suitable connector. In some embodiments, a channel 115 can extend from the connector 114 through the distal end of the plunger 16. In some embodiments, the connector 114 can be disposed within the plunger 16. In some embodiments, the connector 114 can be disposed distally of the proximal end 116 of the plunger 16.

[0120] In some embodiments, the instrument 22 can extend from the distal end 118 of the plunger 16. In some embodiments, the channel 115 can provide a fluid path for fluid infusion and / or blood extraction. In some embodiments, a blood collection device or a fluid infusion device can be coupled to the connector 114. In some embodiments, the distal end of the extension tube can be coupled to the connector 114. In some embodiments, the proximal end of the extension tube 120 can be coupled to the blood collection device or the infusion device. In some embodiments, the extension tube 120 can be in fluid communication with the channel 115 to provide a fluid path for fluid infusion and / or blood extraction.

[0121] In some embodiments, the distal end 26 of the syringe 12 can include a distal connector 34, such as a sliding or threaded male or female Luer adapter, or another suitable connector. In some embodiments, the distal connector 34 can be configured to be coupled to the proximal end of a catheter adapter. In some embodiments, the syringe 12 can be coupled to the proximal end of a catheter adapter 32 of a catheter assembly 30 (e.g., at Figures 1A-1B and 2A-2B ), and the plunger 16 can be depressed to advance the instrument 22 in a distal direction such that the instrument 22 is disposed in the fluid path of the catheter assembly 30 and / or is advanced beyond the distal end 48 of the catheter 36.

[0122] Now refer to Figure 10C In some embodiments, the distal end of extension tube 120 can be integrated into plunger 16. In some embodiments, the proximal end of extension tube 120 can be coupled to a blood collection device or an infusion device. In some embodiments, extension tube 120 can be in fluid communication with channel 115 to provide a fluid path for fluid infusion and / or blood withdrawal.

[0123] Now refer to Figure 11 , according to some embodiments, an example method 100 is shown. In some embodiments, the method 100 may begin at block 102. In block 102, a delivery device may be coupled to a catheter adapter. The delivery device may include or correspond to the delivery device of one or more of Figures 1-10. In some embodiments, the delivery device may be coupled to a catheter adapter via a needleless connector and / or an interface connector (e.g., Figures 4A-4B The interface adapter 60) is connected to the catheter adapter.

[0124] In some embodiments, block 102 may be followed by block 104. At block 104, the catheter adapter may be flushed with a liquid, such as saline or another suitable flushing liquid, while the delivery device instrument is advanced distally. In some embodiments, the delivery device instrument may be advanced distally into the patient's vasculature. The instrument may include or correspond to one or more of instruments 22 in Figures 1-10. In some embodiments, the catheter adapter may be flushed with a liquid, and the instrument may be advanced distally by depressing the delivery device plunger.

[0125] In some embodiments, block 104 may be followed by block 106. In block 106, a blood sample may be collected using a delivery device. In some embodiments, the blood sample may be collected in a blood collection device coupled to the delivery device.

[0126] In some embodiments, frame 106 may be followed by frame 108. In frame 108, the instrument may be retracted proximally. In some embodiments, when the instrument is retracted proximally, the distal end of the instrument may be disposed within the delivery device or interface adapter.

[0127] In some embodiments, block 108 may be followed by block 110. In block 110, the delivery device may be detached from the catheter adapter. Although illustrated as discrete blocks, the various blocks of method 100 may be separated into additional blocks, combined into fewer blocks, or eliminated, depending on the desired implementation. For example, in some embodiments, block 108 may be eliminated.

[0128] All examples and conditional language described herein are for teaching purposes to help readers understand the present invention and the concepts contributed by the inventors to expand this field, and are interpreted as not being limited to these specific examples and conditions. Although embodiments of the present invention have been described in detail, it should be understood that various changes, substitutions, and modifications may be made thereto without departing from the spirit and scope of the present invention.

Claims

1. A delivery device for delivering an instrument into a catheter assembly, comprising: a syringe having a barrel and a plunger movable within the barrel; an instrument coupled to the plunger and movable along the plunger to an advanced position, wherein the instrument extends distally into the barrel, wherein a distal end of the instrument is configured to be advanced distally of a distal end of the syringe; wherein the plunger includes a rib, wherein the instrument is coupled to and movable along the rib; wherein the instrument is coupled to the rib via a pusher tab extending on the rib; and wherein the barrel contains a liquid, wherein the liquid is expelled from a distal opening of the syringe in response to depression of the plunger, wherein the distal opening of the syringe has a diameter greater than an outer diameter of the device.

2. A delivery device for delivering an instrument into a catheter assembly, comprising: a syringe having a barrel and a plunger movable within the barrel; an instrument coupled to the plunger and movable along the plunger to an advanced position, wherein the instrument extends distally into the barrel, wherein a distal end of the instrument is configured to be advanced distally of a distal end of the syringe; wherein the plunger includes a slot, wherein the instrument is disposed within the barrel and coupled to a push tab movable along the slot; and wherein the barrel contains a liquid, wherein the liquid is expelled from a distal opening of the syringe in response to depression of the plunger, wherein the distal opening of the syringe has a diameter greater than an outer diameter of the device.

3. A delivery device for delivering an instrument into a catheter assembly, comprising: a syringe having a barrel and a plunger movable within the barrel; an instrument coupled to the plunger and movable along the plunger to an advanced position, wherein the instrument extends distally into the barrel, wherein a distal end of the instrument is configured to be advanced distally of a distal end of the syringe; wherein the plunger comprises a stopper, wherein the instrument moves through the stopper in response to movement of the plunger to the advanced position; and wherein the barrel contains a liquid, wherein the liquid is expelled from a distal opening of the syringe in response to depression of the plunger, wherein the distal opening of the syringe has a diameter greater than an outer diameter of the device.

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