Electromagnetic field cancer treatment circuit

By designing an electromagnetic field cancer treatment circuit, and using a central processing unit and various circuit components to achieve closed-loop feedback and personalized treatment, the problems of long cycle, large radiation, and high energy consumption of existing electromagnetic field treatments are solved, improving the safety and efficiency of treatment and providing personalized treatment plans.

CN115738086BActive Publication Date: 2025-12-05ZHEJIANG NUROTRON BIOTECH
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Patent Information

Application Number
CN202211294714.9
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2022-10-21
Publication Date
2025-12-05
Estimated Expiration
2042-10-21

AI Technical Summary

Technical Problem

Existing electromagnetic field cancer treatment methods suffer from problems such as long treatment cycles, severe radiation, inconvenience, high energy consumption, and inconvenience for patients, and lack closed-loop feedback and personalized treatment capabilities.

Method used

An electromagnetic field cancer treatment circuit was designed, comprising a central processing unit, a power supply unit, a sampling unit, and a magnetic field control unit. It employs a high-voltage power supply, a current source, an H-bridge, and protection circuits, combined with an ADC, an amplifier circuit, and an angle sensor, to achieve closed-loop feedback and personalized treatment. Controlled by an STM32 microcontroller, it supports multi-channel expansion and current waveform modulation, and features real-time monitoring and enhanced safety.

Benefits of technology

It achieves precise control of voltage, current, and frequency, reduces radiation and energy consumption, shortens treatment time, provides personalized treatment plans, enhances safety and treatment effectiveness, avoids skin electrode contamination problems, and supports multi-channel alternating stimulation and real-time feedback.

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Abstract

The application discloses an electromagnetic field cancer treatment circuit, wherein a central processing unit is connected with a power supply part, a sampling part and a magnetic field control unit respectively, the power supply part comprises a high-voltage power supply, a current source, an H bridge and a protection circuit, wherein the input of the high-voltage power supply, the input of the current source and the input of the H bridge are connected with the output of the central processing unit, the output of the H bridge is connected with the input of the protection circuit, and the output of the protection circuit is connected with the high-voltage power supply and the central processing unit respectively; the sampling part comprises an ADC, an amplification circuit and a sampling electrode, wherein the sampling electrode collects signals at the carrier of the H bridge output electric stimulation, and the signals are output to the central processing unit after being amplified by the amplification circuit and the ADC; the magnetic field control unit comprises a motor drive and an angle sensor, and both are connected with the central processing unit; and the rotation angle of the motor drive is adjusted according to the angle collected by the angle sensor. The application can adjust the voltage, the current, the frequency and the time accurately, and can realize the closed-loop feedback electric field cancer treatment circuit.
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Description

Technical Field

[0001] This invention belongs to the field of medical devices, and specifically relates to an electromagnetic field cancer treatment circuit. Background Technology

[0002] Current cancer treatments include: surgical treatment (including surgery and minimally invasive surgery, which is the most effective treatment for most tumors); radiotherapy; drug treatment (including chemotherapy, immunotherapy, and molecular targeted therapy); and local treatment (including interventional therapy, thermotherapy, radiofrequency ablation, laser therapy, cryotherapy, and microwave therapy). Scientists have proposed a new method for treating cancer based on inhibiting cell mitosis using electric field signals. Existing technologies include the following solutions:

[0003] A magnetic field generator applies an active magnetic field (AP) to the target area of ​​the human body. This AP magnetic field has a frequency of 0.5-500 kHz and a field strength of 0.05-5 mT. The AP magnetic field selectively affects cancer cells to achieve at least one of the following: destroying cancer cells, inhibiting cancer cell growth, reducing tumor size, inhibiting angiogenesis, or preventing cancer cell metastasis, while leaving non-cancer cells substantially unharmed. This method has drawbacks, including a very long treatment period for patients and significant radiation exposure.

[0004] This device uses a strong magnetic field higher than 0.4T (Tesla) to treat cancer, employing both constant and pulsed strong magnetic fields, with a magnetic field range of 0.4T-50T. This method involves high radiation, long operating periods, inconvenience, and high energy consumption.

[0005] The low-intensity current electric field cancer treatment device has no frequency in the circuit section and no closed-loop feedback in the current regulation section. Summary of the Invention

[0006] In view of this, to overcome the above problems, the present invention provides an electromagnetic field cancer treatment circuit, comprising at least: a central processing unit, a power supply unit, a sampling unit, and a magnetic field control unit, wherein the central processing unit is respectively connected to the power supply unit, the sampling unit, and the magnetic field control unit.

[0007] The power supply unit includes a high-voltage power supply, a current source, an H-bridge, and a protection circuit. The inputs of the high-voltage power supply, the current source, and the H-bridge are all connected to the output of the central processing unit. The output of the H-bridge is connected to the input of the protection circuit, and the output of the protection circuit is connected to both the high-voltage power supply and the central processing unit.

[0008] The sampling unit includes an ADC, an amplification circuit, and sampling electrodes. The sampling electrodes collect signals at the carrier of the H-bridge output electrical stimulation, which are then amplified by the ADC and output to the central processing unit.

[0009] The magnetic field control unit includes a motor drive and an angle sensor, both of which are connected to the central processing unit. The rotation angle of the motor drive is adjusted by the angle collected by the angle sensor.

[0010] Preferably, it also includes a keyboard and a display module, which is connected to the central processing unit to transmit control signals, display data and alarm information from the host computer to the central processing unit.

[0011] Preferably, the central processing unit includes an STM32 microcontroller.

[0012] Preferably, the high-voltage power supply includes a high-voltage operational amplifier, a Zener diode, two voltage divider resistors, a PWM comparator, a totem-pole driver circuit, a main switch, an energy storage inductor, an energy storage capacitor, a freewheeling diode, and a sampling resistor, wherein...

[0013] The input of the high-voltage operational amplifier is connected to the output of the digital-to-analog converter module in the central processing unit or the output of an independent digital-to-analog converter controlled by the central processing unit. The output of the high-voltage operational amplifier is protected against inrush pulses using a Zener diode. The output of the high-voltage operational amplifier is connected to one input of a PWM comparator after passing through two voltage divider resistors. The output of the PWM comparator is connected to a totem-pole drive circuit. The other input of the PWM comparator is connected to a sampling resistor. The output of the totem-pole drive circuit is connected to the main switch. The drain of the main switch is connected to the power supply VCC through an energy storage inductor. The drain of the main switch is also connected to the high-voltage power supply through a freewheeling diode. The energy storage capacitor is also connected to the high-voltage power supply.

[0014] Preferably, the PWM comparator includes a clock generator, an error amplifier, a current sampler, and a basic RS flip-flop, wherein,

[0015] The clock generator output is connected to the S terminal of the basic RS flip-flop. One input terminal of the error amplifier is connected to the output of two voltage divider resistors, and the other input terminal is connected to the output of the current sampler. The output terminal of the error amplifier is connected to the R terminal of the basic RS flip-flop. The Q terminal of the basic RS flip-flop is connected to the totem pole driver circuit. One input terminal of the current sampling circuit is connected to the sampling resistor, and the other input terminal is grounded.

[0016] Preferably, the totem pole driving circuit includes two transistors arranged vertically, referred to as the upper transistor and the lower transistor. The upper transistor is an NPN transistor, and the lower transistor is a PNP transistor. The bases of the upper and lower transistors are connected, serving as the input terminals of the totem pole driving circuit. The emitters of the upper and lower transistors are connected, serving as the output terminals of the totem pole driving circuit. The collector of the upper transistor is connected to the power supply VCC, and the collector of the lower transistor is grounded.

[0017] Preferably, the current source includes a current output DAC, a capacitor, an integrated operational amplifier biasing operational amplifier, a first operational amplifier, a second operational amplifier, a first switching transistor, a second switching transistor, a grounding resistor, a non-inverting resistor, and an inverting resistor, wherein,

[0018] The digital input of the current output DAC is connected to the parallel output of the central processing unit. The output of the current output DAC is connected to the inverting input of the integrated operational amplifier. The output of the current output DAC is also connected to the current output DAC via capacitor feedback.

[0019] The non-inverting input of the integrated operational amplifier is connected to the output of the bias operational amplifier, the output of the integrated operational amplifier is connected to the non-inverting input of the first operational amplifier, the inverting input of the first operational amplifier is grounded through a grounding resistor, the output of the first operational amplifier is connected to the gate of the first switching transistor, and the source of the first switching transistor is also grounded through a grounding resistor.

[0020] The non-inverting input of the second operational amplifier is connected to the drain of the first switching transistor. One end of the non-inverting resistor is connected to the non-inverting input of the second operational amplifier, and the other end is connected to the high-voltage power supply. The inverting input of the second operational amplifier is connected to the source of the second switching transistor and one end of the inverting resistor. The other end of the inverting resistor is connected to the high-voltage power supply. The drain of the second switching transistor is connected to the input of the H-bridge.

[0021] Preferably, the H-bridge includes n modules, where n is an integer. One module drives one pair of stimulation electrodes. Each module includes four N-channel switches and four totem-pole H-bridge drivers. The inputs of the four totem-pole H-bridge drivers are connected to the central processing unit, and the outputs of the four totem-pole H-bridge drivers are respectively connected to the four N-channel switches. The four N-channel switches are turned on in pairs and can achieve polarity reversal at the output.

[0022] The beneficial effects of the present invention include at least the following:

[0023] 1. A closed-loop feedback electric field cancer treatment circuit that can precisely control voltage, current, frequency, and time, and achieve closed-loop feedback. Functionally, it realizes functions not found in existing circuits and adds a safety circuit.

[0024] 2. To avoid problems such as dirt and oil buildup from long-term use of skin electrodes, which can lead to poor performance;

[0025] 3. Compared to magnetic field therapy, it has lower radiation and lower energy consumption for the same effect;

[0026] 4. Compared to magnetic field therapy, it is more effective and has a shorter treatment time;

[0027] 5. Parameters can be configured and downloaded via the host computer interface, making it convenient for doctors to carry out personalized treatment based on the characteristics of the patient's disease progression, and to adjust the stimulation current, frequency, and stimulation duration;

[0028] 6. It can monitor the orientation of the static magnetic field in real time and adjust it precisely;

[0029] 7. It can be expanded to multiple paths to achieve alternating stimulation with different electrodes, effectively avoiding short-circuit problems;

[0030] 8. Set up sampling feedback for the patient's skin current, which can provide real-time feedback on the current stimulation status and transmit it to the host computer for recording;

[0031] 9. It can achieve power isolation within the same network, increasing security;

[0032] 10. Modulating different current waveforms can better inhibit cell mitosis to achieve the best results;

[0033] 11. It is digitally controlled, and the duty cycle, voltage, current and frequency of the treatment are all adjustable. Compared with analog control, it is more precise and easier to implement the overcurrent protection function. Attached Figure Description

[0034] To make the objectives, technical solutions, and beneficial effects of this invention clearer, the following figures are provided for illustration:

[0035] Figure 1 This is an overall block diagram of the electromagnetic field cancer treatment circuit according to an embodiment of the present invention;

[0036] Figure 2 This is a schematic diagram of the high-voltage power supply circuit of the electromagnetic field cancer treatment circuit according to an embodiment of the present invention;

[0037] Figure 3 This is a schematic diagram of the current source circuit of the electromagnetic field cancer treatment circuit according to an embodiment of the present invention;

[0038] Figure 4 This is a schematic diagram of the H-bridge circuit of the electromagnetic field cancer treatment circuit according to an embodiment of the present invention;

[0039] Figure 5 This is a waveform diagram of the output current of the electromagnetic field cancer treatment circuit in Embodiment 1 of the present invention;

[0040] Figure 6 This is a waveform diagram of the output current of the electromagnetic field cancer treatment circuit in Embodiment 2 of the present invention;

[0041] Figure 7 This is a waveform diagram of the output current of the electromagnetic field cancer treatment circuit in Embodiment 3 of the present invention;

[0042] Figure 8 This is a waveform diagram of the output current of the electromagnetic field cancer treatment circuit in Embodiment 4 of the present invention. Detailed Implementation

[0043] The preferred embodiments of the present invention will now be described in detail with reference to the accompanying drawings.

[0044] See Figure 1The diagram shows an overall block diagram of an electromagnetic field cancer treatment circuit according to an embodiment of the present invention. It includes a central processing unit 27, a power supply unit, a sampling unit, and a magnetic field control unit 32. The central processing unit 27 is connected to the power supply unit, the sampling unit, and the magnetic field control unit 32 respectively. The power supply unit includes a high-voltage power supply 21, a current source 20, an H-bridge 25, and a protection circuit 28. The inputs of the high-voltage power supply 21, the current source 20, and the H-bridge 25 are all connected to the outputs of the central processing unit 27. The output of the H-bridge 25 is connected to the input of the protection circuit 28. The output of the protection circuit 28 is connected to the high-voltage power supply 21 and the central processing unit 27 respectively.

[0045] The sampling unit includes an ADC29, an amplifier circuit 30, and a sampling electrode 31. The sampling electrode 31 collects signals at the carrier where the H-bridge 25 outputs electrical stimulation, and then outputs them to the central processing unit 27 after passing through the amplifier circuit 30 and the ADC29.

[0046] The magnetic field control unit 32 includes a motor drive 33 and an angle sensor 34, both of which are connected to the central processing unit 27. The rotation angle of the motor drive 33 is adjusted by the angle collected by the angle sensor 34.

[0047] In a specific embodiment, a keyboard and display module 26 is also included, which is connected to the central processing unit 27 and transmits control signals, display data and alarm information from the host computer to the central processing unit 27.

[0048] The central processing unit 27 includes an STM32 microcontroller. The central processing unit 27 controls a controllable high-voltage power supply 21, whose output voltage range is 0-200V. This power supply then supplies power to an adjustable current source 20, whose current adjustment range is 0-2mA. The current source 20 is converted into positive and negative stimulation currents through an H-bridge 25. The current output of the H-bridge 25 is sampled and fed back to the protection circuit 28. If the current exceeds a threshold, the protection circuit 28 immediately cuts off the control of the high-voltage power supply 21, providing protection. The protection circuit 28 consists of a comparator composed of operational amplifiers. After the current output of the H-bridge 25 is sampled, it is compared with the comparator's voltage (threshold voltage). If the threshold voltage is exceeded, the high-voltage power supply 21 and the entire circuit are shut down, and a signal is sent to the central processing unit 27 to trigger an alarm. The driving signal is a PWM (Pulse Width Modulation) signal, which originates from the central processing unit 27.

[0049] The sampling electrode 31 amplifies the signal sampled by the skin electrode and sends it to the central processing unit 27. The central processing unit 27 then sends it to the host computer for the user to adjust the output parameters.

[0050] The magnetic field control unit 32 has a gimbal-type mechanical structure, which can be driven by a motor 33 to rotate in different directions, and the current actual equipment angle is fed back by an angle sensor 34.

[0051] The host computer has a communication structure and a keyboard input interface for controlling voltage, current, frequency, stimulation time, alarm display, and start / stop. This part is a basic function and will not be described in detail.

[0052] The current source 20 uses a parallel high-speed AD converter, and through IV conversion and offset setting, it finally achieves voltage-controlled current output.

[0053] See Figure 2 The high-voltage power supply 21 includes a high-voltage operational amplifier 106, a Zener diode 111, two voltage divider resistors 109 and 112, a PWM comparator, a totem-pole driver circuit, a main switch 108, an energy storage inductor 101, an energy storage capacitor 105, a freewheeling diode 102, and a sampling resistor 115.

[0054] The input DAC_OUT of the high-voltage operational amplifier 106 is connected to the output of the digital-to-analog converter module in the central processing unit 27 or the output of the independent digital-to-analog converter controlled by the central processing unit 27. After being compared with the reference voltage REF, DAC_OUT is amplified by the high-voltage operational amplifier 106. The output of the high-voltage operational amplifier 106 is protected against inrush pulses by a Zener diode 111. The output of the high-voltage operational amplifier 106 is connected to one input terminal of the PWM comparator after passing through two voltage divider resistors 109 and 112. The output of the PWM comparator is connected to the totem pole drive circuit. The other input terminal of the PWM comparator is connected to the sampling resistor 115. The input signal is the voltage signal after being converted by the sampling resistor 115. The output of the totem pole drive circuit is connected to the main switch 108. The drain of the main switch 108 is connected to the power supply VCC through the energy storage inductor 101. The drain of the main switch 108 is also connected to the high-voltage power supply 21 through the freewheeling diode 102. The energy storage capacitor 105 is also connected to the high-voltage power supply 21.

[0055] The PWM comparator includes a clock generator 103, an error amplifier 110, a current sampler 113, and a basic RS flip-flop 104. The output of the clock generator 103 is connected to the S terminal of the basic RS flip-flop 104. One input terminal of the error amplifier 110 is connected to the output of two voltage divider resistors, and the other input terminal is connected to the output of the current sampler 113. The output terminal of the error amplifier 110 is connected to the R terminal of the basic RS flip-flop 104. The Q terminal of the basic RS flip-flop 104 is connected to the totem pole driver circuit. One input terminal of the current sampling circuit is connected to the sampling resistor 115, and the other input terminal is grounded.

[0056] The totem pole driver circuit includes two transistors arranged vertically, referred to as the upper and lower transistors. The upper transistor 107 is an NPN transistor, and the lower transistor 114 is a PNP transistor. The bases of the upper transistor 107 and the lower transistor 114 are connected, serving as the input terminals of the totem pole driver circuit. The emitters of the upper transistor 107 and the lower transistor 114 are connected, serving as the output terminals of the totem pole driver circuit. The collector of the upper transistor 107 is connected to the power supply VCC, and the collector of the lower transistor 114 is grounded.

[0057] join Figure 3 The current source 20 includes a current output DAC 304, a capacitor 303, an integrated operational amplifier 307, a bias operational amplifier 310, a first operational amplifier 308, a second operational amplifier 309, a first switching transistor Q13, a second switching transistor Q14, a grounding resistor 311, a non-inverting resistor 301, and an inverting resistor 302. The digital input of the current output DAC 304 is connected to the parallel output of the central processing unit 27. The output of the current output DAC 304 is connected to the inverting input of the integrated operational amplifier 307. The output of the current output DAC 304 is also connected to the current output DAC via feedback input through capacitor 303. 305 is the power supply for the current output DAC 304, and 306 is the reference voltage. 313 provides a bias voltage for fine-tuning the operating point of the first switching transistor Q13.

[0058] D1-Dn are the parallel outputs of the central processing unit 27. The central processing unit 27 configures the output of the current output DAC 304 through this output interface.

[0059] The non-inverting input of the integrated operational amplifier 307 is connected to the output of the bias operational amplifier 310. The output of the integrated operational amplifier 307 is connected to the non-inverting input of the first operational amplifier 308. The inverting input of the first operational amplifier 308 is grounded through the grounding resistor 311. The output of the first operational amplifier 308 is connected to the gate of the first switching transistor Q13. The source of the first switching transistor Q13 is also grounded through the grounding resistor 311.

[0060] The non-inverting input of the second operational amplifier 309 is connected to the drain of the first switching transistor Q13. One end of the non-inverting resistor 301 is connected to the non-inverting input of the second operational amplifier 309, and the other end is connected to the high-voltage power supply 21. The inverting input of the second operational amplifier 309 is connected to the source of the second switching transistor Q14 and one end of the inverting resistor 302. The other end of the inverting resistor 302 is connected to the high-voltage power supply 21. The drain of the second switching transistor Q14 is connected to the input of the H-bridge 25. The current source 20 generates currents with different waveforms to better prevent the development of tolerance problems in regular cells. Two different current stimulation modes can be selected, and the stimulation sequence is selectable. Figure 5-8 The solid line represents one stimulus waveform mode, and the dashed line represents another stimulus waveform mode. Both can be selected via the host computer.

[0061] See Figure 4The H-bridge 25 comprises n modules, where n is an integer. Each module drives one pair of stimulation electrodes. Each module includes four N-channel switches and four totem-pole H-bridge drivers. The inputs of the four totem-pole H-bridge drivers are connected to the central processing unit 27, and the outputs of the four totem-pole H-bridge drivers are respectively connected to the four N-channel switches. The four N-channel switches are paired and can achieve polarity reversal at the output. The output of the high-voltage power supply 21 is connected to the current source 20, which outputs to the four N-channel switches Q1-Q4. Q5-Q12 form four pairs of totem-pole H-bridge drivers to drive Q1-Q4. I05 is the power supply for the totem-pole H-bridge drivers. Q1, Q4 and Q2, Q3 are sequentially paired and conduct, thus creating a polarity reversal between the DC blocking capacitor 206 and the output electrode 207. One side of the DC blocking capacitor 206 and the output electrode 207 are respectively connected to the two ends of the stimulation electrode. 204, 205, 208, and 209 are the drive signals for Q5-Q12, respectively, which come from the central processing unit.

[0062] The voltage output by the stimulation electrode at the skin is collected by the sampling electrode 31, amplified by the amplifier circuit 30 and sent to the ADC 29 for acquisition. Finally, the central processing unit 27 acquires the voltage and displays it or sends it to the host computer.

[0063] Finally, it should be noted that the above preferred embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. Although the present invention has been described in detail through the above preferred embodiments, those skilled in the art should understand that various changes can be made to it in form and detail without departing from the scope defined by the claims of the present invention.

Claims

1. An electromagnetic field cancer treatment circuit, comprising: The application relates to a high-voltage stimulation device, which comprises a central processor, a power supply unit, a sampling unit and a magnetic field control unit, wherein the central processor is connected with the power supply unit, the sampling unit and the magnetic field control unit respectively, The power supply unit comprises a high-voltage power supply, a current source, an H bridge and a protection circuit, wherein the input of the high-voltage power supply, the input of the current source and the input of the H bridge are connected with the output of the central processor, the output of the H bridge is connected with the input of the protection circuit, and the output of the protection circuit is connected with the high-voltage power supply and the central processor respectively; The sampling unit comprises an ADC, an amplification circuit and a sampling electrode, wherein the sampling electrode collects signals at the carrier of the output electric stimulation of the H bridge, the signals are output to the central processor after being amplified by the amplification circuit and the ADC, and the central processor is connected with the power supply unit, the sampling unit and the magnetic field control unit respectively; The magnetic field control unit comprises a motor driver and an angle sensor, and the motor driver and the angle sensor are connected with the central processor; the rotation angle of the motor driver is adjusted according to the angle collected by the angle sensor; The high-voltage power supply comprises a high-voltage operational amplifier, a voltage stabilizing diode, two voltage dividing resistors, a PWM comparator, a totem pole driving circuit, a main switch, an energy storage inductor, an energy storage capacitor, a freewheeling diode and a sampling resistor, wherein the input of the high-voltage operational amplifier is connected with the output of a digital-to-analog conversion module in the central processor or the output of an independent digital-to-analog converter controlled by the central processor, the output of the high-voltage operational amplifier is protected from impulse by the voltage stabilizing diode, the output of the high-voltage operational amplifier is connected with one input end of the PWM comparator after passing through the two voltage dividing resistors, the output of the PWM comparator is connected with the totem pole driving circuit, the other input end of the PWM comparator is connected with the sampling resistor, the output of the totem pole driving circuit is connected with the main switch, the drain of the main switch is connected with the power supply VCC through the energy storage inductor, the drain of the main switch is also connected with the high-voltage power supply through the freewheeling diode, and the energy storage capacitor is also connected with the high-voltage power supply. The device further comprises a keyboard and a display module, which are connected with the central processor and transmit control signals, display data and alarm information of an upper computer to the central processor.

2. The electromagnetic field cancer treatment circuit of claim 1, wherein, The central processor comprises an STM32 single-chip microcomputer.

3. The electromagnetic field cancer treatment circuit of claim 1, wherein, The PWM comparator comprises a clock generator, an error amplifier, a current sampler and a basic RS flip-flop, wherein the output of the clock generator is connected with the S end of the basic RS flip-flop, one input end of the error amplifier is connected with the output of the two voltage dividing resistors, the other input end of the error amplifier is connected with the output of the current sampler, the output end of the error amplifier is connected with the R end of the basic RS flip-flop, the Q end of the basic RS flip-flop is connected with the totem pole driving circuit, one input end of the current sampling circuit is connected with the sampling resistor, and the other input end is grounded.

4. The electromagnetic field cancer treatment circuit of claim 1, wherein, The totem pole driving circuit comprises two triodes which are arranged in an upper-lower relationship and are called upper and lower triodes, the upper triode is an NPN triode, the lower triode is a PNP triode, the base of the upper triode is connected with the base of the lower triode and serves as the input end of the totem pole driving circuit, the emitter of the upper triode is connected with the emitter of the lower triode and serves as the output end of the totem pole driving circuit, the collector of the upper triode is connected with the power supply VCC, and the collector of the lower triode is grounded. The current source comprises a current output DAC, a capacitor, an integrated operational amplifier, a bias operational amplifier, a first operational amplifier, a second operational amplifier, a first switch tube, a second switch tube, a grounding resistor, a non-inverting resistor and an inverting resistor, wherein 5. The electromagnetic field cancer treatment circuit of claim 1, wherein, ​ 6. The electromagnetic field cancer treatment circuit of claim 1, wherein, ​ The digital input end of the current output DAC is connected with the parallel output of the central processor, the output end of the current output DAC is connected with the inverting input end of the integrated operational amplifier, and the output end of the current output DAC is also connected with the current output DAC through the capacitor feedback input, The non-inverting input end of the integrated operational amplifier is connected with the output of the bias operational amplifier, the output of the integrated operational amplifier is connected with the non-inverting input end of the first operational amplifier, the inverting input end of the first operational amplifier is grounded through a grounding resistor, the output of the first operational amplifier is connected with the gate of the first switch tube, and the source of the first switch tube is also grounded through a grounding resistor. The non-inverting input end of the second operational amplifier is connected with the drain of the first switch tube, one end of the non-inverting resistor is connected with the non-inverting input end of the second operational amplifier, and the other end is connected with the high-voltage power supply, the inverting input end of the second operational amplifier is connected with the source of the second switch tube and one end of the inverting resistor, the other end of the inverting resistor is connected with the high-voltage power supply, and the drain of the second switch tube is connected with the input of the H bridge.

7. The electromagnetic field cancer treatment circuit of claim 1, wherein, The H bridge includes n modules, n is an integer, one module drives one pair of stimulating electrodes, each module includes four N-channel switch tubes and four totem pole H bridge drives, the input of the four totem pole H bridge drives is connected with the central processor, the output of the four totem pole H bridge drives is respectively connected with the four N-channel switch tubes, the four N-channel switch tubes are turned on in pairs, and can realize polarity conversion at the output end.

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