Dental cleaning composition

Abstract

This invention provides a dental cleaning composition containing anionic surfactants, which exhibits moderately suppressed foaming, low foaming properties, and a pleasant user experience. The dental cleaning composition comprises: (A) one or more anionic surfactants selected from acyl taurine, acyl amino acids, alkyl sulfuric acid, and their salts; (B) one or more anionic surfactants selected from fatty acid triglycerides and vegetable and animal oils that are liquid at 25°C; and (C) a nonionic surfactant. The content of component (B) is 0.05–1.5% by mass, and the mass ratio of (B) to (A) is 1–10.

Description

Technical Field

[0001] This invention relates to a dental cleaning composition that moderately suppresses foaming, has low foaming properties, and provides a pleasant user experience. Background Technology

[0002] Dental cleaning agents typically contain abrasives, surfactants, humectants, binders, etc. By mixing anionic surfactants as surfactants, they can achieve cleaning effects such as stain removal in the oral cavity, and thus exhibit antibacterial effects, giving the mouth a refreshing feeling after brushing.

[0003] However, among users of dental cleaning compositions, such as elderly people who require care, oral function is reduced, and rinsing after brushing is often insufficient. In addition, when rinsing is difficult, they often just wipe the inside of their mouth with wet wipes, so the foam in the mouth cannot be completely removed, and sometimes it may leave an irritating and unpleasant taste.

[0004] However, even with small amounts of anionic surfactants, foaming is still high. Therefore, to suppress foaming in a dental cleaning composition containing anionic surfactants, a larger amount of defoaming agents needs to be added. Fragrance ingredients also have defoaming properties, but these additions affect the user experience of the dental cleaning composition and limit its design. Therefore, it is impossible to achieve both low foaming and a refreshing mouthfeel without simultaneously suppressing foaming.

[0005] Existing technical documents

[0006] Patent documents

[0007] Patent Document 1: Japanese Patent Application Publication No. 2005-289917

[0008] Patent Document 2: Japanese Patent Application Publication No. 2015-89870

[0009] Patent Document 3: Japanese Patent Application Publication No. 2015-231972 Summary of the Invention

[0010] The problem that the invention aims to solve

[0011] The present invention was made in view of the above circumstances, and its object is to provide a dental cleaning composition containing an anionic surfactant that has moderately suppressed foaming, low foaming properties, and a good user experience.

[0012] Methods for solving problems

[0013] To achieve the above objectives, the inventors conducted in-depth research and discovered that if a specific amount of fatty acid triglycerides, or a specific vegetable or animal oil, is mixed in a specific ratio with the anionic surfactant in a tooth-cleaning composition, and is combined with a nonionic surfactant, foaming can be moderately suppressed even with the presence of anionic surfactants, resulting in low foaming. Moreover, even if foaming is barely noticeable, a refreshing sensation (sometimes referred to as a refreshing sensation) can be provided in the mouth after brushing. In addition, appearance stability can be ensured. That is, according to the tooth-cleaning composition of the present invention, it has been found that the foaming of the following tooth-cleaning composition is moderately suppressed, has low foaming properties, a good user experience, and has appearance stability, thereby completing the present invention. The tooth-cleaning composition contains: (A) one or more anionic surfactants selected from acyl taurine, acyl amino acids, alkyl sulfuric acid and their salts, (B) one or more anionic surfactants selected from fatty acid triglycerides, vegetable oils and animal oils that are liquid at 25°C, and (C) a nonionic surfactant. The content of component (B) is 0.05 to 1.5% by mass, and the mass ratio of (B) to (A) is 1 to 10.

[0014] In this invention, if a specific amount of component (B) and a mass ratio of (B) / (A) within a specific range are used in component (A) and component (C) is mixed in combination, then components (A) and (B) interact stably and specifically, thereby imparting the aforementioned special effects.

[0015] In this case, in the present invention, by combining components (A), (B) and (C), while maintaining the washing effect and other effects produced by component (A), foaming and foam persistence are suppressed, foaming is reduced, and component (B) is stably mixed even after time has passed. Thus, even with low foaming, a refreshing feeling can be given in the mouth after use, and appearance stability can be ensured.

[0016] As shown in the comparative examples described later, in Comparative Examples 1, 3, and 4, which contained component (A) but not component (B) in the tooth-cleaning composition, the foaming was poor even when liquid paraffin or shea butter was added together with component (C). Furthermore, in Comparative Examples 5 and 6, which contained components (A) and (B) but not component (C), the appearance stability was poor even when the amphoteric surfactant coconut oil fatty acid amamidopropyl betaine was added. In Comparative Examples 7 and 8, which contained components (A), (B), and (C) but had an inappropriate (B) / (A) mass ratio, the foaming or refreshing sensation was poor. In Comparative Example 9, which contained excessive (B) component, the refreshing sensation and appearance stability were poor. In contrast, as shown in the examples, the tooth-cleaning composition containing components (A), (B), and (C) of the present invention, with the (B) component amount and (B) / (A) mass ratio within a specific range, exhibited excellent foaming, a good refreshing sensation, and good appearance stability.

[0017] Patent documents 1-3 disclose tooth-cleaning compositions containing sucrose fatty acid esters or liquid oils mixed with anionic surfactants, but these compositions do not suppress foaming. It is difficult to conceive of the present invention, which achieves low foaming while ensuring a pleasant feel and stable appearance, by combining components (B) and (C) in component (A).

[0018] Therefore, the present invention provides the following dental cleaning composition.

[0019] [1] A dental cleaning composition comprising:

[0020] (A) One or more anionic surfactants selected from acyl taurine, acyl amino acids, alkyl sulfuric acid and their salts.

[0021] (B) Selected from one or more of the following: fatty acid triglycerides, vegetable oils and animal oils that are liquid at 25°C, and...

[0022] (C) Nonionic surfactants,

[0023] The content of component (B) is 0.05 to 1.5% by mass, and the ratio of (B) to (A) by mass is 1 to 10.

[0024] [2] In the dental cleaning composition according to [1], component (A) is selected from acyl amino acids and their salts.

[0025] [3] According to the dental cleaning composition of [1] or [2], the fatty acid triglyceride is a fatty acid triglyceride with 6 to 20 carbon atoms that is liquid at 25°C, and the vegetable oil and animal oil that is liquid at 25°C are soybean oil, safflower oil, olive oil, avocado oil, corn germ oil, liver oil and shark oil.

[0026] [4] In any one of [1] to [3], component (C) is a polyglycerol fatty acid ester having 12 to 18 carbon atoms.

[0027] [5] The dental cleaning composition according to [4], wherein the polyglycerol fatty acid ester having 12 to 18 carbon atoms is selected from one or more of hexadecyl laurate and decadecyl laurate.

[0028] [6] The dental cleaning composition according to any one of [1] to [5] contains 0.05 to 1.5% by mass of component (A) and 0.1 to 2% by mass of component (C).

[0029] [7] The dental cleaning composition according to any one of [1] to [6], wherein (C) / (B) is 0.5 to 5 by mass.

[0030] Invention Effects

[0031] According to the present invention, a dental cleaning composition containing anionic surfactants can be provided, exhibiting moderately suppressed foaming, low foaming properties, and a pleasant user experience. This dental cleaning composition removes foam from the mouth with only a light rinsing or simple wiping action after brushing, providing both the cleaning effect produced by component (A) and a refreshing sensation in the mouth, making it effective for oral care by a wide range of users. Detailed Implementation

[0032] The present invention will now be described in more detail.

[0033] The dental cleaning composition of the present invention contains (A) one or more anionic surfactants selected from acyl taurates, acyl amino acid salts and alkyl sulfates, (B) one or more anionic surfactants selected from fatty acid triglycerides, vegetable oils and animal oils that are liquid at 25°C, and (C) a nonionic surfactant.

[0034] (A) The component is one or more anionic surfactants selected from acyl taurine, acyl amino acids, alkyl sulfuric acid and their salts.

[0035] Acyl taurine, acyl amino acids, or their salts preferably have an acyl group with 8 to 18 carbon atoms, and alkyl sulfuric acid or its salts preferably have an alkyl group with 8 to 12 carbon atoms. These salts are preferably alkali metal salts such as sodium salts.

[0036] As ingredient (A), examples include acyl amino acid salts such as sodium lauroyl sarcosinate and sodium cocoyl sarcosinate, acyl taurate such as sodium cocoyl methyl taurate and sodium lauroyl methyl taurate, alkyl sulfates such as sodium lauroyl sulfate and ammonium lauryl sulfate. In particular, from the viewpoint of inhibiting foaming and providing a refreshing feeling, acyl amino acid salts are preferred, and sodium lauroyl sarcosinate is more preferred.

[0037] (A) The mixing amount of the component is preferably 0.05 to 1.5% (by mass) of the whole composition, more preferably 0.1 to 1%, and even more preferably 0.1 to 0.3%. The more the mixing amount, the more refreshing the feeling can be obtained. When the mixing amount is less than 1.5%, foaming is sufficiently suppressed and the degree of foaming is excellent.

[0038] In addition, in the dental cleaning composition of the present invention, other anionic surfactants, such as alkyl phosphates or polyoxyethylene monoalkyl phosphates, may be mixed in, except for component (A), without impairing the effect of the present invention. However, these arbitrary anionic surfactants may not be mixed.

[0039] (B) Component is one or more selected from fatty acid triglycerides, vegetable oils and animal oils that are liquid at 25°C. These substances act as defoamers to maintain the washing effect and other effects produced by component (A), moderately inhibiting foaming and thus creating a low-foaming effect.

[0040] As component (B), any one of the following can be used: fatty acid triglycerides, vegetable oils that are liquid at 25°C, and animal oils that are liquid at 25°C. Alternatively, from the viewpoint of performance, two or three of these can be used in combination. Of these, fatty acid triglycerides are preferred from the viewpoint of foaming ability.

[0041] Fatty acid triglycerides are liquid at 25°C, and the fatty acids have 6 to 20 carbon atoms. Fatty acid triglycerides with 8 to 10 carbon atoms are particularly preferred. For example, medium-chain fatty acid triglycerides (a mixture of fatty acids with 8 and 10 carbon atoms) can be cited.

[0042] Vegetable and animal oils that are liquid at 25°C include, for example, soybean oil, safflower oil, olive oil, avocado oil, and corn germ oil, as well as animal oils such as liver oil and shark oil. In particular, from the perspective of foaming degree, vegetable oils are preferred.

[0043] (B) One ingredient can be used alone or in combination of two or more. In addition, commercially available products can be used.

[0044] (B) The mixing amount of component is 0.05 to 1.5% of the total composition, preferably 0.1 to 1%, more preferably 0.1 to 0.5%. When the mixing amount is less than 0.05%, the foaming effect is poor, and when it is greater than 1.5%, the refreshing feeling is reduced. In addition, liquid separation and other issues may occur after storage, resulting in poor appearance stability.

[0045] (C) Nonionic surfactants act as solubilizers to ensure that (B) components are mixed stably after preservation and to impart appearance stability.

[0046] (C) Examples of nonionic surfactants include glycerol fatty acid esters, polyglycerol fatty acid esters, polyoxyethylene hydrogenated castor oil with an average addition molar number of ethylene oxide of 3 to 30 moles (especially 5 to 20 moles), polyoxyethylene alkyl ethers with 12 to 18 carbon atoms in the alkyl group and an average addition molar number of ethylene oxide of 2 to 40 moles (especially 5 to 20 moles), and polyoxyethylene sorbitan fatty acid esters. Glycerol fatty acid esters are preferably glycerol fatty acid esters with 12 to 18 carbon atoms in the fatty acid, specifically including glyceryl myristate and glyceryl oleate. Polyglycerol fatty acid esters are preferably fatty acid esters with 12 to 18 carbon atoms in the fatty acid, specifically including hexadecyl laurate, decadecyl laurate, decadecyl oleate, decadecyl pentaoleate, and decadecyl distearate. In terms of appearance stability and refreshing feel, polyglycerol fatty acid esters, polyoxyethylene hydrogenated castor oil, and polyoxyethylene alkyl ethers are preferred. In particular, in terms of refreshing feel, polyglycerol fatty acid esters are more preferred, and hexadecyl laurate and decadecyl laurate are even more preferred.

[0047] Nonionic surfactants can be used alone or in combination of two or more. In addition, commercially available products can be used.

[0048] The mixing amount of component (C) is preferably 0.1 to 2% of the total composition, more preferably 0.2 to 1%, and even more preferably 0.2 to 0.7%. When the mixing amount is 0.1% or more, component (B) is also stably mixed after storage, and sufficient appearance stability can be obtained. If it is 2% or less, sufficient non-foaming and refreshing sensation can be obtained. When the mixing amount is greater than 2%, foaming may not be suppressed, and a sufficient refreshing sensation may not be obtained.

[0049] The ratio of (B) to (A), representing the amount of component (A) to component (B), is 1 to 10 by mass, preferably 2 to 7, and more preferably 3 to 5. When the mass ratio of (B) to (A) is less than 1, foaming cannot be suppressed and the degree of foaming is poor; when it is greater than 10, it results in an oily feel and does not provide a refreshing sensation.

[0050] Furthermore, the ratio of (C) / (B), representing the molar ratio of component (B) to component (C), is preferably 0.5 to 5 by mass, more preferably 1 to 3. Within this range, the foaming effect is superior, the refreshing sensation is better, and the appearance stability is improved. When the mass ratio of (C) / (B) is less than 0.5, the appearance stability may decrease; when it is greater than 5, foaming may be difficult to suppress.

[0051] The dental cleaning composition of the present invention can be in various dosage forms such as toothpaste, liquid dental cleaning agent, liquid dental cleaning agent, and wet powder (wetting) dental cleaning agent, and is particularly suitable as toothpaste. In this case, depending on the purpose and dosage form of the composition, appropriate known ingredients may be mixed in addition to the above-mentioned components. For example, abrasives, humectants, binders, and surfactants may be mixed, and preservatives, sweeteners, colorants, flavorings, pH adjusters, and active ingredients may be mixed as needed, and these ingredients are then mixed with water to manufacture the product. Furthermore, these arbitrary ingredients can be mixed in the usual amounts as needed. Hereinafter, the mixing amount is relative to the total amount of the composition.

[0052] Abrasives can include silica-based abrasives such as anhydrous silica, precipitated silica, aluminum silicate, and zirconium silicate; calcium phosphate-based compounds such as dicalcium phosphate dihydrate or anhydrous dicalcium phosphate; and calcium carbonate and synthetic resin-based abrasives. The preferred mixing amount of the abrasive is 0–50%, and more preferably 5–15% during mixing.

[0053] Furthermore, the dental cleaning composition of the present invention can be prepared without mixing with abrasives, and the effects of the present invention can be obtained even when it is prepared as a non-abrasive dental cleaning agent.

[0054] Examples of wetting agents include sugar alcohols such as sorbitol and xylitol, and polyols such as glycerol and propylene glycol. The mixing amount of wetting agents is usually 5% to 50%, especially 10% to 30%.

[0055] Binders can be mixed with organic or inorganic binders. Specifically, examples include cellulose derivatives such as sodium carboxymethyl cellulose, methyl cellulose, and hydroxymethyl cellulose; alginate derivatives; gums such as xanthan gum; organic binders such as sodium polyacrylate; and inorganic binders such as thickening silica and thickening aluminum silica. The mixing amount of binder is typically 0.1% to 10%.

[0056] Furthermore, in this invention, an organic binder is particularly preferred, and the mixing amount of the organic binder is preferably 0.1 to 5%, particularly preferably 0.5 to 3%.

[0057] Examples of any surfactant include cationic surfactants such as alkylammonium type and alkylbenzylammonium salt, acetate-type surfactants such as alkyl betaine and fatty acid amyl propyl betaine, and amphoteric surfactants such as alkyl imidazoline betaine and 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazoline betaine (alkyl imidazoline) type.

[0058] The mixing amount of any surfactant is 0-10%, preferably 0.001-10%, and particularly preferably 0.1-5%.

[0059] Examples of preservatives include methylparaben (para-hydroxybenzoate), benzoic acid, or their salts.

[0060] Sweeteners include sodium saccharin.

[0061] Colorants include Blue No. 1, Yellow No. 4, and titanium dioxide.

[0062] Spices can be used in combination, including peppermint oil, spearmint oil, fennel oil, eucalyptus oil, wintergreen oil, cinnamon oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, citrus oil, lime oil, lavender oil, rosemary oil, bay berry oil, chamomile oil, caraway oil, marjoram oil, bay leaf oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie oil, pomelo oil, iris extract, and peppermint absolute. Natural fragrances such as peppermint, rose absolute, and orange blossom, as well as fragrances obtained by processing these natural fragrances (excluding the initial fraction, excluding the after-fraction, fractionation, liquid-liquid extraction, rectification, fragrance powdering, etc.); and menthol, carvone, anethole, eucalyptol, methyl salicylate, cinnamaldehyde, eugenol, 3-L-menthoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted-p-menthane-3-carboxamide, pinene, octanal, citral, menthol, carvone acetate, anisaldehyde, ethyl acetate, ethyl butyrate, etc. The fragrances used in the dental cleaning agent composition include single fragrances such as allyl cyclohexanepropionate, methyl anthranilate, ethyl methylphenyl glycidyl propionate, vanillin, undecyl lactone, hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, methylcyclopentenolone, furfural, trimethylpyrazine, ethyl lactate, and ethyl thioester; as well as blended fragrances such as strawberry, apple, banana, pineapple, grape, mango, butter, milk, mixed fruit, and tropical fruit fragrances, and other known fragrance raw materials, not limited to the fragrances described in the examples.

[0063] There is no particular limitation on the mixing amount of the spices, but the above-mentioned spice raw materials are preferably used in the composition at 0.000001 to 1%. The flavoring agent using the above-mentioned spice raw materials is preferably used in the composition at 0.1 to 2%.

[0064] pH adjusters can be added, such as citric acid, sodium citrate, or their salts.

[0065] The active ingredients include fluorine-containing compounds such as sodium fluoride and sodium monofluorophosphate, nonionic bactericides such as isopropyl methylphenol, cationic bactericides such as cetylpyridinium chloride, anti-inflammatory agents such as tranexamic acid and allantoin, enzymes such as dextranase, water-soluble phosphoric acid compounds, inorganic salts such as sodium chloride, potassium nitrate, and aluminum lactate, vitamins such as ascorbic acid and tocopherol acetate, plant extracts, tartar prevention agents, and plaque prevention agents. The active ingredients can be mixed in effective amounts within a range that does not impair the effectiveness of the invention.

[0066] [Example]

[0067] The following examples and comparative examples illustrate the present invention in detail, but the invention is not limited to the following examples. Furthermore, in the following examples, unless otherwise specified, % represents mass%.

[0068] [Example, Comparative Example]

[0069] The toothpaste compositions (compositions) shown in Tables 1-3 were prepared using conventional methods, and were used as samples for evaluation using the methods described below. The results are recorded in the tables.

[0070] <Evaluation Methods for User Experience (Foaming Degree, Refreshing Feel)>

[0071] The freshly prepared samples were evaluated by five professional reviewers who were also test subjects, based on their user experience (level of foaming, refreshing feeling).

[0072] Place 1g of sample on a toothbrush (Clinica Advantage toothbrush, 4-column compact standard type, manufactured by Lion Corporation), brush your teeth for 3 minutes, and rinse with water.

[0073] Regarding foaming during use (brushing) and the refreshing feeling in the mouth after use (rinsing), the following scoring criteria were used for evaluation. The average score of the 5 participants was calculated, and the degree of foaming and the refreshing feeling were evaluated according to the following evaluation criteria.

[0074] Scoring criteria for foaming degree

[0075] 5: Almost no bubbling is felt.

[0076] 4: I feel some bubbling.

[0077] 3: Slightly feel bubbling

[0078] 2: Bubbling is quite noticeable.

[0079] 1: The bubbling is very noticeable.

[0080] Evaluation criteria for foaming level (set ○ or above as acceptable)

[0081] ☆: The average score of the 5 people is above 4.5.

[0082] ◎: The average score of the 5 people is 4 or higher but less than 4.5.

[0083] ○: The average score of the 5 people is 3 or higher but less than 4.

[0084] ×: The average score of the 5 people is less than 3 points.

[0085] Scoring criteria for a refreshing feeling

[0086] 5: A noticeable refreshing feeling

[0087] 4: Feeling refreshed

[0088] 3: A slight feeling of refreshment

[0089] 2: I don't really feel refreshed.

[0090] 1: I didn't feel any refreshing sensation at all.

[0091] Evaluation criteria for a refreshing feeling (set ○ or above as acceptable)

[0092] ☆: The average score of the 5 people is above 4.5.

[0093] ◎: The average score of the 5 people is 4 or higher but less than 4.5.

[0094] ○: The average score of the 5 people is 3 or higher but less than 4.

[0095] ×: The average score of the 5 people is less than 3 points.

[0096] <Evaluation Methods for Appearance Stability>

[0097] Fill 90g of the freshly prepared sample into a general aluminum laminated tube container, store it at 60°C for 1 month, squeeze the sample out of the container, visually judge the appearance of the formulation (whether there is liquid separation), and evaluate the appearance stability according to the following evaluation criteria.

[0098] Evaluation criteria for appearance stability (set as ○ or above as qualified).

[0099] ◎: No liquid separation at all

[0100] ○: Slight liquid separation is visible at the pipe opening, but the level is not problematic.

[0101] ×: Liquid separation is visible from the pipe opening to the interior.

[0102] The details of the raw materials used are shown below.

[0103] (A)Ingredients

[0104] Sodium lauroyl sarcosine:

[0105] Manufactured by Kawaken Fine Chemicals Co., Ltd., trade name: SOYPON SLP

[0106] Sodium dodecyl sulfate:

[0107] Made by BASF Japan Co., Ltd., trade name: Texapon OC-P

[0108] Sodium lauroyl methyl taurate:

[0109] Manufactured by Nikko Chemical Co., Ltd., trade name: NIKKOL LMT

[0110] (B) Ingredients

[0111] Fatty acid triglycerides:

[0112] (A mixture of fatty acids with 8 and 10 carbon atoms, and the carbon chain composition ratio of fatty acids: C8: 70%, C10: 30%)

[0113] Made by Fuji Oil Co., Ltd., trade name; MCT-73

[0114] olive oil:

[0115] Manufactured by Nikko Chemical Co., Ltd., product name: NIKKOL Olive Oil

[0116] Safflower oil:

[0117] Manufactured by Nikko Chemical Co., Ltd., product name: NIKKOL Safflower Oil

[0118] (B') Liquid paraffin (comparative composition):

[0119] Manufactured by Sanko Chemical Co., Ltd., Product Name: Liquid Paraffin 350-S

[0120] (B') Shea butter (comparative component):

[0121] Croda Made in Japan, trade name; CROPURE SHEA BUTTER

[0122] (C) Components

[0123] Laurate decaglyceride:

[0124] Manufactured by Sakamoto Pharmaceutical Co., Ltd., trade name: SY Glyster

[0125] Polyoxyethylene (20) hydrogenated castor oil:

[0126] NIPPON SURFACTANT INDUSTRIES CO.,LTD, product name: NIKKOL HCO-20

[0127] Polyoxyethylene (5) stearate:

[0128] Manufactured by Lion Chemical, product name: RHA-155SCE

[0129] (C') Coconut oil fatty acid amamidopropyl betaine (30% aqueous solution) (Comparative component): Manufactured by Degussa, trade name: TEGO BETAIN CK-OK

[0130] In addition, in the table, components (A) to (C), (B'), and (C') represent the mixed amounts after purity conversion.

[0131] [Table 1]

[0132]

[0133] [Table 2]

[0134]

[0135] [Table 3]

[0136]

Claims

1. A toothpaste composition comprising: (A) one or more anionic surfactants selected from the group consisting of sodium lauroyl sarcosinate, sodium dodecyl sulfate and sodium lauroyl methyl taurate, (B) one or more selected from the group consisting of fatty acid triglycerides, olive oil and safflower oil, and (C) one or more nonionic surfactants selected from the group consisting of decaglyceryl laurate, polyoxyethylene (20) hydrogenated castor oil and polyoxyethylene (5) stearyl ether, the content of the (B) component being 0.05 to 1.5 mass%, and (B) / (A) being 2 to 8 in mass ratio, the fatty acid triglyceride being a fatty acid triglyceride of a fatty acid having 8 to 10 carbon atoms which is liquid at 25°C.

2. The toothpaste composition according to claim 1, wherein (B) / (A) is 3 to 5 in mass ratio.

3. The toothpaste composition according to claim 1 or 2, comprising 0.05 to 1.5 mass% of the (A) component and 0.1 to 2 mass% of the (C) component.

4. The toothpaste composition according to claim 1 or 2, wherein (C) / (B) is 0.5 to 5 in mass ratio.

5. The toothpaste according to claim 1 or 2, wherein (C) / (B) is 1 to 3 in mass ratio.

6. The toothpaste composition according to claim 1 or 2, wherein the total amount of abrasive is 0 to 50 mass%. No abrasive is mixed. ​ ​ ​ ​ ​ 7. The toothpaste composition according to claim 1 or 2, wherein, ​

Images