Baicalin-Copper Composite Nanocoated Sheath Tube and Its Preparation Method and Use

The yellow gin-copper composite nano-coating on radial artery sheaths enhances endothelial cell repair and migration, addressing the vulnerability of endothelial cells during interventional procedures and reducing radial artery closure risk.

CN116603116BActive Publication Date: 2025-07-15TIANJIN MEDICAL UNIVERSITY GENERAL HOSPITAL +1
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Patent Information

Application Number
CN202310746926.4
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-06-25
Publication Date
2025-07-15
Estimated Expiration
2043-06-25

AI Technical Summary

Technical Problem

The prior art is difficult to effectively protect the radial artery and avoid radial artery occlusion after interventional surgery, especially when the effect of using thicker sheaths and antispasmodic drugs is brief, and endothelial cell injury is the key pathophysiological basis for radial artery occlusion.

Method used

The preparation method of baicalin-copper composite nano-coated sheath tube is adopted. The baicalin-copper composite is coated on the outside of the sheath tube by ultrasonic spraying, and combined with laser drilling to form micropores, promoting endothelial cell proliferation and migration, and providing continuous endothelial protection.

Benefits of technology

During the interventional surgery, the baicalin-copper complex is in full contact with endothelial cells, promoting endothelial cell repair, significantly reducing the risk of near- and long-term occlusion of the radial artery, and improving the patient's diagnosis and treatment experience and effect.

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Abstract

The present invention provides a baicalin - copper composite nano - coated sheath tube, its preparation method and uses. The preparation method includes the following steps: (1) Prepare a baicalin - copper complex; (2) Coat the baicalin - copper complex on the outer wall of the sheath tube by ultrasonic spraying to make a sheath tube with a baicalin - copper composite nano - coating on its outer wall. And through laser drilling or etching, uniformly distributed micropores are formed on the sheath tube. The present invention provides a sheath tube with a baicalin - copper composite nano - coating on its outer wall. The drug - protecting coating on the outer side of the sheath tube of the present invention enables the radial artery sheath tube with the drug coating to be in full contact with the vascular endothelium during the interventional operation. The drugs in the coating are absorbed by endothelial cells, playing functions such as promoting the proliferation and migration of endothelial cells, being able to protect the vascular endothelial function to a greater extent during the interventional operation, reducing the risk of vascular occlusion in the short - term and long - term after the operation, and greatly improving the diagnosis and treatment experience and effect of patients.
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