Balloon catheter with directional drug release and method thereof

Abstract

The application discloses a balloon catheter capable of directional drug release and a method thereof, and relates to the technical field of medical machinery. The balloon catheter capable of directional drug release comprises a catheter body, a drug feeding mechanism and a protection mechanism. The drug feeding mechanism comprises a second balloon, a second air extraction pipeline, an extension assembly and a drug placement plate. The protection mechanism comprises an inner support, a third balloon, a third air extraction pipeline and a protection cylinder. The inner support is fixedly installed on the catheter body at a position close to the second balloon. An end of the inner support, which is far away from the catheter, is slidably connected with a limiting block. The limiting block is fixedly connected with the protection cylinder. One end of the protection cylinder is fixedly connected with the third balloon. The other end of the protection cylinder penetrates through the third balloon and is slidably connected with the third balloon. The third balloon is in communication with the third air extraction pipeline through a third air extraction branch pipeline. The protection cylinder is closed to protect the drug coated in the drug placement groove, so that the drug coated in the drug placement groove is prevented from being washed by high-speed flowing blood, and the drug delivery efficiency is improved.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and more specifically, to a balloon catheter capable of targeted drug delivery and a method thereof. Background Technology

[0002] A drug-eluting balloon catheter is a medical interventional device. Its mechanism of action involves coating the outer surface of a balloon with a drug coating. After the drug-loaded balloon is delivered to the lesion site, the balloon expands according to the characteristics of the lesion site, allowing the drug on the outer surface of the balloon to adhere to the blood vessel wall at the lesion site. Then the balloon is withdrawn.

[0003] Currently, because the drug coating is applied to the outer surface of the balloon, the drug coating on the outer surface of the balloon is washed away by the high-speed blood flow during the delivery of the drug-coated balloon catheter into the blood vessel, resulting in a high drug loss rate. This reduces the amount of drug that can be released by the drug-coated balloon at the lesion site, leading to poor treatment efficacy. Summary of the Invention

[0004] In view of the shortcomings of the existing technology, the purpose of this invention is to provide a balloon catheter and method for targeted drug release, in order to solve the above-mentioned technical problems.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a balloon catheter capable of directional drug release, the balloon catheter comprising a catheter body, a handle fixedly connected to one end of the circumferential surface of the catheter body, a tip provided at the end of the catheter body away from the handle, and the balloon catheter further comprising a drug delivery mechanism and a protection mechanism;

[0006] A connector is fixedly installed on the handle. A first inner lumen and a second inner lumen are respectively opened in the catheter body. The first inner lumen extends along the setting direction of the catheter body, and the end of the first inner lumen away from the tip passes through the catheter body. The first inner lumen is used to push the guidewire. The second inner lumen extends along the setting direction of the catheter body. A through groove is opened in the connector, and the end of the second inner lumen away from the tip communicates with the through groove.

[0007] The drug delivery mechanism includes a second balloon, a second suction pipe, a telescopic component, and a drug placement plate. The second balloon is fixedly mounted on the catheter body and positioned near the tip. The second balloon is connected to a second suction branch pipe, which passes through the catheter body into the second inner lumen and is fixedly connected to the catheter body. The end of the second suction branch pipe away from the second balloon is connected to the second suction pipe, which passes through the second inner lumen and a through groove. Multiple telescopic components are fixedly connected to the end of the catheter body near the second balloon. Each telescopic component is connected to a drug placement plate at the end away from the catheter body. A drug placement groove is formed at the end of the drug placement plate away from the telescopic component. The drug placement groove is used to coat the drug. The telescopic component is used to adjust the distance between the drug placement plate and the catheter body.

[0008] The protective mechanism includes an inner support, a third balloon, a third suction tube, and a protective sleeve. The inner support is fixedly installed on the catheter body near the second balloon. A limit block is slidably connected to the end of the inner support away from the catheter body. The limit block is fixedly connected to the inner wall of the protective sleeve facing the catheter body. One end of the protective sleeve is located on the side of the inner support away from the second balloon, and is fixedly connected to one end of the third balloon. The other end of the protective sleeve passes through the third balloon and is slidably connected to it. A fixing ring is fixedly connected to the side of the protective sleeve away from the third balloon. The end face of the drug-eluting plate away from the catheter body is provided with an arc-shaped protrusion. The fixing ring abuts against the arc-shaped protrusion. The end of the third balloon near the inner stent is fixedly connected to the inner stent. The third balloon is connected to the third suction pipe through the third suction branch tube. One end of the third suction branch tube is fixedly connected to the third balloon, and the other end of the third suction branch tube is fixedly connected to the third suction pipe. The third suction branch tube passes through the catheter body to the second inner lumen and is fixedly connected to the catheter body. The third suction pipe passes through the second inner lumen and the through groove.

[0009] When the drug delivery plate is in the drug delivery position, the distance between the drug delivery plate and the catheter body is minimal, and the second balloon contracts. The surface of the second balloon is spaced apart from the drug delivery plate. The third balloon contracts, and the protective tube moves along the axis of the catheter body. The protective tube moves away from the third balloon to a position that covers the multiple drug delivery slots.

[0010] When the drug-placement plate is in the drug delivery position, the third balloon inflates, the protective sleeve moves along the axis of the catheter body, and the protective sleeve moves towards the third balloon to expose multiple drug-placement slots. The second balloon inflates and the surface of the second balloon rubs against the drug-placement plate. The distance between the drug-placement plate and the catheter body is at its maximum, and the distance between the coated surface of the drug-placement slot and the catheter body is equal to or greater than the distance between the third balloon and the catheter body.

[0011] As a further aspect of the present invention: the telescopic component includes a sleeve and a guide post, one end of the sleeve is fixedly connected to the catheter body, the other end of the sleeve is slidably connected to the guide post, and the end of the guide post away from the sleeve is fixedly connected to the drug placement plate.

[0012] As a further aspect of the present invention: a contrast ring is fixedly connected to the circumferential wall of the catheter body located between the inner stent and the second balloon, and the contrast ring is used to locate the drug release position.

[0013] As a further embodiment of the present invention: the protective mechanism further includes an outer support, a fourth balloon, and a fourth suction pipe. The outer support is disposed on the side of the inner support away from the second balloon, and the outer support is fixedly connected to the catheter body. The fourth balloon is fixedly connected to the side of the outer support away from the catheter body. The end of the fourth balloon away from the outer support is fixedly connected to the protective cylinder. The fourth balloon is connected to the fourth suction pipe through a fourth suction branch pipe. One end of the fourth suction branch pipe is fixedly connected to the fourth balloon, and the other end of the fourth suction branch pipe is fixedly connected to the fourth suction pipe. The fourth suction branch pipe passes through the catheter body to the second inner lumen, and the fourth suction branch pipe is fixedly connected to the catheter body. The fourth suction pipe passes through the second inner lumen and the through groove.

[0014] When the drug delivery plate is in the drug delivery position, the fourth balloon inflates; when the drug delivery plate is in the drug feeding position, the fourth balloon deflates.

[0015] As a further embodiment of the present invention: the drug feeding mechanism further includes a guide rod, a wedge, a squeezing plate, a first suction branch pipe, and a first suction pipe. One end of the guide rod is fixedly connected to the side end of the drug placement plate, and the other end of the guide rod is slidably connected to a guide groove. The guide groove is opened in an adjacent drug placement plate. The guide rod has an arcuate convex portion, wherein, along the radial direction of the catheter body, the lowest point of the arcuate convex portion of the guide rod is close to the opening of the guide groove, and the highest point of the arcuate convex portion of the guide rod is far from the opening of the guide groove. The arcuate convex portion of the guide rod is pressed against the wedge. The end of the wedge away from the guide rod is fixedly connected to a squeezing plate, and the squeezing plate is slidably connected in the drug placement cavity, which is opened in the drug placement plate. A spring is sleeved on the side wall of the wedge located between the drug placement cavity and the squeezing plate. One end of the spring is fixedly connected to the inner wall of the drug placement cavity, and the other end of the spring is fixedly connected to the squeezing plate. The side of the squeezing plate is sealed and fitted to the inner wall of the drug placement cavity. The drug placement chamber is divided into two areas. The area on the side of the extrusion plate away from the wedge is the drug placement area. The drug placement area is connected to the drug placement groove through a through hole. A connecting branch pipe is fixedly connected to the side wall of the drug placement chamber near the through hole. One-way valves are installed at the connection point between the connecting branch pipe and the drug placement chamber and in the through hole, respectively. The one-way valves installed at the connection point between the connecting branch pipe and the drug placement chamber and the one-way valve installed in the through hole have opposite conduction directions. The other end of the connecting branch pipe is connected to the drug placement chamber in the adjacent drug placement plate. The connecting branch pipe is used to connect the drug placement chamber in the adjacent drug placement plate. The connecting branch pipe is connected to the first suction pipe through a first suction branch pipe. One end of the first suction branch pipe is fixedly connected to the connecting branch pipe. The other end of the first suction branch pipe passes through the conduit body to the second inner lumen. The first suction branch pipe is fixedly connected to the first suction pipe and the first suction branch pipe is fixedly connected to the conduit body.

[0016] When the drug delivery plate is in the drug delivery position, the guide rod is in the initial position, and the squeezing plate is located at the end of the drug delivery cavity near the wedge.

[0017] When the drug-feeding plate is in the drug feeding position, the guide rod moves to its maximum displacement along the extension direction of the guide groove, and the extrusion plate moves to its maximum displacement away from the wedge block.

[0018] The present invention also provides a method using a balloon catheter capable of targeted drug release, wherein the balloon catheter capable of targeted drug release described above is used.

[0019] As a further aspect of the present invention, the method using a balloon catheter capable of targeted drug release includes the following steps:

[0020] The drug that needs to be released in a targeted manner is coated into the drug placement slot on the drug placement plate;

[0021] Air is drawn into the third balloon through the third suction pipe and the third suction branch pipe, causing the third balloon to contract. The third balloon drives the protective tube to move along the axis of the catheter body, and the protective tube moves away from the third balloon to its maximum displacement. The protective tube then closes, thus protecting the drug coated in the opposing drug tank.

[0022] By pushing the guidewire placed in the first inner lumen, the catheter body moves the second balloon to the lesion location.

[0023] Inflation is achieved by pumping air into the third balloon through the third suction pipe and the third suction branch pipe, causing the third balloon to expand. The third balloon then moves the protective tube along the axis of the catheter body, and the protective tube moves towards the third balloon to its initial position, at which point the protective tube opens.

[0024] Inflation is achieved by pumping air into the second balloon through the second suction pipe and the second suction branch pipe, causing the second balloon to expand. The outer surface of the second balloon rubs against the drug-filled plate, causing the drug-filled plate to move to its maximum displacement along the telescopic direction of the telescopic assembly, releasing the drug coated in the drug-filled groove to the lesion site.

[0025] As a further aspect of the present invention, the method using a balloon catheter capable of targeted drug release further includes the following steps:

[0026] After the drug release ends, air is drawn into the second balloon through the second suction pipe and the second suction branch pipe, causing the second balloon to contract. Air is then drawn into the third balloon through the third suction pipe and the third suction branch pipe, causing the third balloon to contract. The third balloon drives the protective cylinder to move along the axis of the catheter body, and the protective cylinder moves away from the third balloon to its maximum displacement, at which point the protective cylinder closes. During this process, the fixing ring presses against the arc protrusion of the drug placement plate, causing the drug placement plate transmission telescopic assembly to contract, and the drug placement plate moves to its initial position along the telescopic direction of the telescopic assembly.

[0027] The catheter body is moved out of the lesion site using a guidewire.

[0028] Compared with the prior art, the technical solution provided by the embodiments of the present invention has at least the following beneficial effects:

[0029] 1. The device of the present invention, by setting a protective mechanism, during the process of the catheter body moving to the lesion position under the push of the guidewire, controls the contraction state of the third balloon in the protective mechanism, and drives the protective cylinder to move along the axis of the catheter body. The protective cylinder moves away from the third balloon to the maximum displacement and the protective cylinder closes, thereby protecting the drug coated in the drug placement tank and preventing the drug coated in the drug placement tank from being washed away by the high-speed flow of blood. This improves the drug delivery efficiency and solves the technical problem that in the process of traditional drug balloon catheters delivering drugs in blood vessels, the drug coating on the outer surface of the balloon is washed away by the high-speed flow of blood, resulting in a high drug loss rate and thus reducing the amount of drug that can be released by the drug-coated balloon at the lesion site.

[0030] 2. Inflation of the second balloon causes it to expand, resulting in friction between its surface and the drug-eluting plate. This pushes the drug-eluting plate towards the lesion, releasing the medication from the drug-eluting slot to the lesion. Simultaneously, guide rods on adjacent drug-eluting plates move along guide grooves, causing their arc-shaped protrusions to rub against wedges. The wedges drive a squeezing plate, moving it away from the wedges within the drug-eluting cavity. This releases the medication from the cavity through the through-hole into the drug-eluting slot, significantly increasing the amount of medication that can be released. Furthermore, the expansion of the third balloon creates a barrier at both ends of the lesion site, effectively preventing the released medication from diffusing to other areas, ensuring concentrated drug release and greatly improving the treatment effect. Attached Figure Description

[0031] To more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0032] Figure 1 This is a schematic diagram of a three-dimensional partial cross-sectional view of a balloon catheter with a drug-eluting plate positioned at the delivery location, provided in an embodiment of the present invention.

[0033] Figure 2 This is a schematic diagram of the overall three-dimensional structure of a balloon catheter capable of targeted drug release, provided in an embodiment of the present invention.

[0034] Figure 3 A partial cross-sectional view of the catheter and protective mechanism in a balloon catheter capable of targeted drug release, provided as an embodiment of the present invention;

[0035] Figure 4 for Figure 1 Enlarged structural diagram at point A;

[0036] Figure 5This is a schematic diagram of a three-dimensional partial cross-sectional view of a balloon catheter with a drug delivery system capable of targeted drug release, located at the drug delivery position, according to an embodiment of the present invention.

[0037] Figure 6 A cross-sectional view of a balloon catheter capable of targeted drug release located at the drug infeed position, as provided in an embodiment of the present invention.

[0038] Figure 7 for Figure 6 Enlarged schematic diagram of the structure at point B.

[0039] Figure label:

[0040] 1. Tip; 2. First inner lumen; 3. Imaging ring; 4. Connector; 5. Handle; 6. Catheter; 7. Drug delivery mechanism; 71. Second suction pipe; 72. Second suction branch pipe; 73. Second balloon; 74. Drug placement plate; 75. Drug placement tray; 76. Sleeve; 77. Guide post; 78. First suction branch pipe; 79. Connecting branch pipe; 710. First suction pipe; 711. Guide rod; 712. Squeezing plate; 7 13. Wedge; 714. Spring; 715. Through hole; 716. Drug placement chamber; 717. Guide groove; 8. Protective mechanism; 81. Outer support; 82. Inner support; 83. Limiting block; 84. Fixing ring; 85. Protective cylinder; 86. Third suction pipe; 87. Third balloon; 88. Third suction branch pipe; 89. Fourth balloon; 810. Fourth suction branch pipe; 811. Fourth suction pipe; 9. Second inner lumen. Detailed Implementation

[0041] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of them. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention.

[0042] In the description of this invention, it should be understood that the terms "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this invention.

[0043] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this invention, "a plurality of" means two or more, unless otherwise explicitly specified.

[0044] Reference Figures 1 to 7 An embodiment of a balloon catheter capable of targeted drug release according to the present invention will be further described.

[0045] Please continue reading. Figures 1 to 7 In one embodiment, a balloon catheter capable of directional drug release includes a catheter body 6, a handle 5 fixedly connected to one end of the circumferential surface of the catheter body 6, and a tip 1 provided at the end of the catheter body 6 away from the handle 5. The balloon catheter also includes a drug delivery mechanism 7 and a protection mechanism 8.

[0046] A connector 4 is fixedly installed on the handle 5. A first inner lumen 2 and a second inner lumen 9 are respectively opened in the catheter body 6. The first inner lumen 2 extends along the setting direction of the catheter body 6, and the end of the first inner lumen 2 away from the tip 1 passes through the catheter body 6. The first inner lumen 2 is used to push the guide wire. The second inner lumen 9 extends along the setting direction of the catheter body 6. A through groove is opened in the connector 4, and the end of the second inner lumen 9 away from the tip 1 is connected to the through groove.

[0047] The drug delivery mechanism 7 includes a second balloon 73, a second suction pipe 71, a telescopic component, and a drug placement plate 74. The second balloon 73 is fixedly installed on the catheter body 6 and is positioned near the tip 1. The second balloon 73 is connected to a second suction branch pipe 72, which passes through the catheter body 6 to the second inner lumen 9 and is fixedly connected to the catheter body 6. The end of the second suction branch pipe 72 away from the second balloon 73 is connected to the second suction pipe 71. The second suction pipe 71 passes through the second inner lumen 9 and the through groove. Multiple telescopic components are fixedly connected to the end of the catheter body 6 near the second balloon 73. Each telescopic component is connected to a drug placement plate 74 at the end away from the catheter body 6. A drug placement groove 75 is opened at the end of the drug placement plate 74 away from the telescopic component. The drug placement groove 75 is used to coat the drug. The telescopic component is used to adjust the distance between the drug placement plate 74 and the catheter body 6.

[0048] The protection mechanism 8 includes an inner support 82, a third balloon 87, a third suction pipe 86, and a protective sleeve 85. The inner support 82 is fixedly installed on the catheter body 6 near the second balloon 73. A limiting block 83 is slidably connected to the end of the inner support 82 away from the catheter body 6. The limiting block 83 is fixedly connected to the inner wall of the protective sleeve 85 facing the catheter body 6. One end of the protective sleeve 85 is located on the side of the inner support 82 away from the second balloon 73, and is fixedly connected to one end of the third balloon 87. The other end of the protective sleeve 85 passes through the third balloon 87 and is slidably connected to it. A fixed component is fixedly connected to the side of the protective sleeve 85 away from the third balloon 87. The fixed ring 84 and the drug placement plate 74 have an arc-shaped protrusion on the end face edge away from the catheter body 6. The fixed ring 84 abuts against the arc-shaped protrusion. The end of the third balloon 87 near the inner stent 82 is fixedly connected to the inner stent 82. The third balloon 87 is connected to the third suction pipe 86 through the third suction branch tube 88. One end of the third suction branch tube 88 is fixedly connected to the third balloon 87, and the other end of the third suction branch tube 88 is fixedly connected to the third suction pipe 86. The third suction branch tube 88 passes through the catheter body 6 to the second inner lumen 9 and is fixedly connected to the catheter body 6. The third suction pipe 86 passes through the second inner lumen 9 and the through groove.

[0049] When the drug placement plate 74 is in the drug delivery position, the distance between the drug placement plate 74 and the catheter body 6 is at its minimum, and the second balloon 73 contracts. The surface of the second balloon 73 is spaced apart from the drug placement plate 74. The third balloon 87 contracts, and the protective cylinder 85 moves along the axis of the catheter body 6. The protective cylinder 85 moves away from the third balloon 87 to a position that covers the multiple drug placement slots 75, thereby protecting the drugs coated in the drug placement slots 75.

[0050] When the drug delivery plate 74 is in the drug delivery position, the third balloon 87 inflates, the protective sleeve 85 moves along the axis of the catheter body 6, and the protective sleeve 85 moves towards the third balloon 87 to the initial position. The second balloon 73 inflates and the surface of the second balloon 73 rubs against the drug delivery plate 74. The drug delivery plate 74 moves to the maximum displacement along the telescopic direction of the telescopic assembly.

[0051] In the above embodiment, when the drug-placement plate 74 is located at the drug delivery position, the distance between the drug-placement plate 74 and the catheter body 6 is minimal, and the second balloon 73 contracts. The surface of the second balloon 73 is spaced apart from the drug-placement plate 74, coating the drug to be released into the drug-placement groove 75 on the drug-placement plate 74. Air is drawn into the third balloon 87 through the third suction pipe 86 and the third suction branch pipe 88, causing the third balloon 87 to contract. The protective cylinder 85 moves along the axis of the catheter body 6 under the constraint and guidance of the limiting block 83, and moves away from the third balloon 87 to a position that covers the multiple drug-placement grooves 75. The protective cylinder 85 closes, protecting the drug coated in the drug-placement grooves 75. The guidewire contained in the first inner lumen 2 is pushed, causing the catheter body 6 to move the second balloon 73 to the lesion position. During this process, the protective cylinder 85 effectively prevents the drug to be released from being washed away by the high-speed flowing blood, ensuring that enough drug is delivered to the lesion position, greatly improving the treatment effect. For example, such as Figure 3 As shown, a contrast ring 3 is fixedly connected to the circumferential wall of the catheter body 6 located between the inner stent 82 and the second balloon 73. The contrast ring 3 is used to locate the drug release position. By effectively locating and tracking the movement position of the second balloon 73 driven by the catheter body 6, precise and directional drug release is achieved. Then, air is inflated into the third balloon 87 through the third suction pipe 86 and the third suction branch pipe 88, causing the third balloon 87 to expand. The third balloon 87 drives the protective cylinder 85 to move along the axis of the catheter body 6, and the protective cylinder 85 moves towards the third balloon 87 to the initial position. The protective cylinder 85 opens, and air is inflated into the second balloon 73 through the second suction pipe 71 and the second suction branch pipe 72, causing the second balloon 73 to expand. The outer surface of the second balloon 73 rubs against the drug placement plate 74, causing the drug placement plate 74 to move along the extension and retraction direction of the telescopic assembly until the distance between the drug placement plate 74 and the catheter body 6 is maximized. For an example, please continue to refer to [the relevant documentation]. Figure 4 The telescopic assembly includes a sleeve 76 and a guide post 77. One end of the sleeve 76 is fixedly connected to the catheter body 6, and the other end of the sleeve 76 is slidably connected to the guide post 77. The end of the guide post 77 away from the sleeve 76 is fixedly connected to a drug-placement plate 74. When the drug-placement plate 74 moves along the telescopic direction of the telescopic assembly to the maximum distance between the drug-placement plate 74 and the catheter body 6, the guide post 77 also slides within the sleeve 76 to its maximum displacement, releasing the drug coated in the drug-placement groove 75 on the drug-placement plate 74 to the lesion site. Simultaneously, the expansion of the third balloon 87 forms a barrier at both ends of the lesion site where the drug is to be released, effectively preventing the released drug from diffusing to other areas, ensuring concentrated drug release, and greatly improving the treatment effect. In other embodiments, the telescopic assembly can be a scissor-type connection assembly, which is not limited here.

[0052] In the above embodiments, the number of protective cylinders 85 corresponds one-to-one with the number of third balloons 87, for example, as shown in... Figure 2 As shown, there are two third balloons 87 and two protective cylinders 85. The paired protective cylinders 85 move towards each other until they come into contact with each other under the drive of their respective connected third balloons 87, thereby achieving a sealing effect. In other embodiments, there is only one protective cylinder 85. The protective cylinder 85 moves under the drive of its connected third balloon 87 until the end of the protective cylinder 85 away from the third balloon 87 contacts the surface of the component directly opposite it along the direction of movement, thereby achieving a sealing effect. The number of protective cylinders 85 is not limited here.

[0053] Please continue reading. Figure 1 , Figure 2 and Figure 3 In one embodiment, the protection mechanism 8 further includes an outer support 81, a fourth balloon 89, and a fourth suction pipe 811. The outer support 81 is disposed on the side of the inner support 82 away from the second balloon 73, and the outer support 81 is fixedly connected to the catheter body 6. The fourth balloon 89 is fixedly connected to the side of the outer support 81 away from the catheter body 6. The end of the fourth balloon 89 away from the outer support 81 is fixedly connected to the protective cylinder 85. The fourth balloon 89 is connected to the fourth suction pipe 811 through the fourth suction branch pipe 810. One end of the fourth suction branch pipe 810 is fixedly connected to the fourth balloon 89, and the other end of the fourth suction branch pipe 810 is fixedly connected to the fourth suction pipe 811. The fourth suction branch pipe 810 passes through the catheter body 6 to the second inner lumen 9, and the fourth suction branch pipe 810 is fixedly connected to the catheter body 6. The fourth suction pipe 811 passes through the second inner lumen 9 and the through groove.

[0054] When the drug delivery plate 74 is in the drug delivery position, the fourth balloon 89 inflates; when the drug delivery plate 74 is in the drug feeding position, the fourth balloon 89 contracts.

[0055] In the above embodiments, by setting the outer support 81 and the fourth balloon 89, during the process of the third balloon 87 contracting and the transmission protective cylinder 85 moving away from the third balloon 87 to its maximum displacement, that is, when the drug placement plate 74 is in the drug delivery position, air is injected into the fourth balloon 89 through the fourth suction pipe 811 and the fourth suction branch pipe 810, causing the fourth balloon 89 to expand, which assists in pushing and squeezing the third balloon 87, thereby achieving stable contraction of the transmission protective cylinder 85 of the third balloon 87 and closing the protective cylinder 85. Similarly, during the process of the third balloon 87 expanding and the transmission protective cylinder 85 moving closer to the third balloon 87 to its initial position, that is, when the drug placement plate 74 is in the drug feeding position, air is drawn into the fourth balloon 89 through the fourth suction pipe 811 and the fourth suction branch pipe 810, causing the fourth balloon 89 to contract, thereby achieving stable expansion of the transmission protective cylinder 85 of the third balloon 87 and opening the protective cylinder 85.

[0056] Please continue reading. Figures 5 to 7 In one embodiment, the drug feeding mechanism 7 further includes a guide rod 711, a wedge 713, a compression plate 712, a first suction branch pipe 78, and a first suction pipe 710. One end of the guide rod 711 is fixedly connected to the side end of the drug placement plate 74, and the other end of the guide rod 711 is slidably connected in a guide groove 717. The guide groove 717 is formed in an adjacent drug placement plate 74. The guide rod 711 has an arcuate protrusion, wherein, along the radial direction of the catheter body 6, the lowest point of the arcuate protrusion of the guide rod 711 is close to the opening of the guide groove 717, and the highest point of the arcuate protrusion of the guide rod 711 is... Positioned away from the opening of the guide groove 717, the arcuate protrusion of the guide rod 711 presses against the wedge block 713. A pressing plate 712 is fixedly connected to the end of the wedge block 713 away from the guide rod 711. The pressing plate 712 is slidably connected in the drug placement cavity 716, which is located within a drug placement plate 74. A spring 714 is sleeved on the side wall of the wedge block 713 between the drug placement cavity 716 and the pressing plate 712. One end of the spring 714 is fixedly connected to the inner wall of the drug placement cavity 716, and the other end is fixedly connected to the pressing plate 712. The side of the pressing plate 712... The inner wall of the drug placement chamber 716 is sealed and fits tightly, dividing the chamber into two areas. The area on the side of the extrusion plate 712 away from the wedge block 713 is the drug placement area. The drug placement area of ​​the drug placement chamber 716 is connected to the drug placement groove 75 through the through hole 715. A connecting branch pipe 79 is fixedly connected to the side wall of the drug placement chamber 716 near the through hole 715. One-way valves are installed at the connection point between the connecting branch pipe 79 and the drug placement chamber 716 and in the through hole 715, respectively. The valve conduction direction is opposite, and the other end of the connecting branch pipe 79 is connected to the drug placement chamber 716 in the adjacent drug placement plate 74. The connecting branch pipe 79 is used to connect the drug placement chamber 716 in the adjacent drug placement plate 74. The connecting branch pipe 79 is connected to the first suction pipe 710 through the first suction branch pipe 78. One end of the first suction branch pipe 78 is fixedly connected to the connecting branch pipe 79. The other end of the first suction branch pipe 78 passes through the catheter body 6 to the second inner lumen 9. The first suction branch pipe 78 is fixedly connected to the first suction pipe 710 and the first suction branch pipe 78 is fixedly connected to the catheter body 6.

[0057] When the drug delivery plate 74 is in the drug delivery position, the guide rod 711 is in the initial position and the squeezing plate 712 is located at one end of the drug delivery cavity 716 near the wedge 713.

[0058] When the drug-feeding plate 74 is in the drug feeding position, the guide rod 711 moves to its maximum displacement along the extension direction of the guide groove 717, and the squeezing plate 712 moves to its maximum displacement in the direction away from the wedge block 713.

[0059] In the above embodiments, when the drug placement plate 74 is in the drug delivery position, the guide rod 711 is in the initial position, and the extrusion plate 712 is located at one end of the drug placement cavity 716 near the wedge 713. At this time, the drug placement area is at its maximum. While the drug to be released is coated in the drug placement groove 75, the drug to be released is injected into the drug placement cavity 716 through the connection position between the connecting branch pipe 79 and the drug placement cavity 716. When the drug placement plate 74 is in the drug feeding position, the drug placement plate 74 moves to its maximum displacement along the telescopic direction of the telescopic assembly under the expansion friction of the second balloon 73. During this process, the guide rod 711 moves from the initial position to the maximum displacement along the extension direction of the guide groove 717. The arc protrusion of the guide rod 711 extrudes the wedge 713, causing the wedge 713 to drive the extrusion plate 712 to move away from the wedge 713 and compress the drug placement area. The drug to be released can then pass through the through hole. 715 is released into the drug placement groove 75 and further released to the lesion location. Through the drug storage in the drug placement chamber 716, the drug delivery rate is greatly increased, ensuring that a sufficient amount of drug is concentrated and released to the lesion location. After the drug release ends, the second balloon 73 contracts. As the drug placement plate 74 moves toward the direction closer to the catheter body 6, the guide rod 711 moves along the extension direction of the guide groove 717 to the initial position. In the process, air is sequentially injected into the drug placement chamber 716 through the first suction pipe 710, the first suction branch pipe 78, and the connecting branch pipe 79. The compression plate 712 is pushed to move toward the direction closer to the wedge block 713. The one-way valve installed in the through hole 715 is used to allow the drug placement chamber 716 to be unidirectionally open toward the drug placement groove 75. The one-way valve installed at the connection between the connecting branch pipe 79 and the drug placement chamber 716 is used to allow the connecting branch pipe 79 to be unidirectionally open toward the drug placement chamber 716.

[0060] This invention also provides a method using a balloon catheter capable of targeted drug release, wherein the balloon catheter capable of targeted drug release described above is used.

[0061] In one embodiment, a method using a balloon catheter capable of targeted drug release includes the following steps:

[0062] The drug that needs to be released in a targeted manner is coated into the drug placement groove 75 on the drug placement plate 74;

[0063] Air is drawn into the third balloon 87 through the third suction pipe 86 and the third suction branch pipe 88, causing the third balloon 87 to contract. The third balloon 87 drives the protective cylinder 85 to move along the axis of the catheter body 6, and the protective cylinder 85 moves away from the third balloon 87 to its maximum displacement. The protective cylinder 85 is then closed, thus protecting the drug coated in the opposing drug tank 75.

[0064] By pushing the guidewire contained in the first inner lumen 2, the catheter body 6 moves the second balloon 73 to the lesion location.

[0065] Inflation is performed on the third balloon 87 through the third suction pipe 86 and the third suction branch pipe 88, causing the third balloon 87 to expand. The third balloon 87 drives the protective cylinder 85 to move along the axis of the catheter body 6, and the protective cylinder 85 moves towards the direction closer to the third balloon 87 to the initial position, and the protective cylinder 85 opens.

[0066] Inflation is achieved by pumping air into the second balloon 73 through the second suction pipe 71 and the second suction branch pipe 72, causing the second balloon 73 to expand. The outer surface of the second balloon 73 rubs against the drug-filled plate 74, causing the drug-filled plate 74 to move to its maximum displacement along the telescopic direction of the telescopic assembly, releasing the drug coated in the drug-filled groove 75 to the lesion site.

[0067] In one embodiment, a method using a balloon catheter capable of targeted drug release further includes the following steps:

[0068] After the drug release ends, air is drawn into the second balloon 73 through the second suction pipe 71 and the second suction branch pipe 72, causing the second balloon 73 to contract. Air is also drawn into the third balloon 87 through the third suction pipe 86 and the third suction branch pipe 88, causing the third balloon 87 to contract. The third balloon 87 drives the protective cylinder 85 to move along the axis of the catheter body 6, and the protective cylinder 85 moves away from the third balloon 87 to its maximum displacement, and the protective cylinder 85 is closed. During this process, the fixing ring 84 presses against the arc protrusion of the drug placement plate 74, causing the drug placement plate 74 to retract the telescopic component, and the drug placement plate 74 moves to the initial position along the telescopic direction of the telescopic component.

[0069] The catheter body 6 is moved out of the lesion location using a guidewire.

[0070] Working Principle: The device of this invention, by setting up a protection mechanism 8 and a drug feeding mechanism 7, firstly coats the drug to be released in the drug placement tank 75 before drug delivery. Simultaneously, the drug to be released is injected into the drug placement chamber 716 through the connection point between the connecting branch pipe 79 and the drug placement chamber 716. At this time, the drug placement plate 74 moves along the telescopic direction of the telescopic assembly until the distance between the drug placement plate 74 and the catheter body 6 is minimized, and the second balloon 73 contracts. The surface of the second balloon 73 is spaced apart from the drug placement plate 74. Air is drawn into the third balloon 87 through the third suction pipe 86 and the third suction branch pipe 88, causing the third... As balloon 87 contracts, protective sleeve 85 moves along the axis of catheter body 6 under the constraint and guidance of limiting block 83. Protective sleeve 85 moves to its maximum displacement away from third balloon 87, and then closes, protecting the drug coated in drug reservoir 75. The guidewire contained in first inner lumen 2 is pushed forward, and combined with the tracking and positioning of contrast ring 3, the catheter body 6 moves second balloon 73 to the lesion site. During this process, protective sleeve 85 effectively prevents the drug to be released from being washed away by high-speed blood flow, ensuring that enough drug is delivered to the lesion site, greatly improving the treatment effect.Then, air is inflated into the third balloon 87 through the third suction pipe 86 and the third suction branch pipe 88, causing the third balloon 87 to expand. Simultaneously, air is drawn into the fourth balloon 89 through the fourth suction pipe 811 and the fourth suction branch pipe 810, causing the fourth balloon 89 to contract. The fourth balloon 89 assists the third balloon 87 in moving the protective sleeve 85 along the axis of the catheter body 6, and the protective sleeve 85 moves towards the initial position closer to the third balloon 87. The protective sleeve 85 opens, and air is inflated into the second balloon 73 through the second suction pipe 71 and the second suction branch pipe 72, causing the second balloon 73 to expand. As balloon 73 inflates, the outer surface of the second balloon 73 rubs against the drug-placement plate 74, causing the drug-placement plate 74 to move along the telescopic direction of the telescopic assembly until the distance between the drug-placement plate 74 and the catheter body 6 is maximized. The drug coated in the drug-placement groove 75 is released to the lesion site. Simultaneously, the guide rod 711 in the drug feeding mechanism 7 moves from its initial position to its maximum displacement along the extension direction of the guide groove 717. The arcuate convex part of the guide rod 711 presses against the wedge block 713, causing the wedge block 713 to drive the compression plate 712 to move away from the wedge block 713 and compress the drug-placement area. The drug to be released can then be released through the through hole 715. The drug is placed in the drug placement tank 75 and further released to the lesion site. The drug storage in the drug placement chamber 716 greatly increases the drug delivery rate, ensuring sufficient drug is concentrated and released to the lesion site. After drug release, the second balloon 73 contracts, and the fixing ring 84, by squeezing against the arcuate protrusion of the drug placement plate 74, moves the drug placement plate 74 closer to the catheter body 6. During this process, the guide rod 711 moves along the extension direction of the guide groove 717 to its initial position, sequentially inflating the drug placement chamber 716 through the first suction pipe 710, the first suction branch pipe 78, and the connecting branch pipe 79, pushing and squeezing... Plate 712 moves toward the wedge 713 until the compression plate 712 is in the initial position. Air is drawn into the second balloon 73 through the second suction pipe 71 and the second suction branch pipe 72, causing the second balloon 73 to contract. Air is drawn into the third balloon 87 through the third suction pipe 86 and the third suction branch pipe 88, causing the third balloon 87 to contract. The third balloon 87 drives the protective sleeve 85 to move along the axis of the catheter body 6, and the protective sleeve 85 moves away from the third balloon 87 to the maximum displacement. The protective sleeve 85 is closed. Finally, the catheter body 6 is moved out of the lesion location through the guidewire.

[0071] The above description is merely a preferred embodiment of the present invention. The scope of protection of the present invention is not limited to the above embodiments. All technical solutions falling within the scope of the present invention's concept are within the scope of protection of the present invention. It should be noted that for those skilled in the art, any improvements and modifications made without departing from the principles of the present invention should also be considered within the scope of protection of the present invention.

Claims

1. A balloon catheter capable of targeted drug delivery, the balloon catheter comprising a catheter body (6), characterized in that, The balloon catheter also includes a drug delivery mechanism (7) and a protection mechanism (8); The drug delivery mechanism (7) includes a second balloon (73), a second suction pipe (71), a telescopic component, and a drug placement plate (74). The second balloon (73) is fixedly installed on the catheter body (6) and is located near the tip (1) of the catheter body (6). The second balloon (73) is connected to the second suction branch pipe (72). Multiple telescopic components are fixedly connected to one end of the circumference of the catheter body (6) near the second balloon (73). Each telescopic component is connected to a drug placement plate (74) at the end away from the catheter body (6). A drug placement groove (75) is opened at the end of the drug placement plate (74) away from the telescopic component. The drug placement groove (75) is used to coat the drug. The telescopic component is used to adjust the distance between the drug placement plate (74) and the catheter body (6). The protective mechanism (8) includes an inner support (82), a third balloon (87), a third suction tube (86), and a protective sleeve (85). The inner support (82) is fixedly installed on the catheter body (6) near the second balloon (73). A limiting block (83) is slidably connected to one end of the inner support (82) away from the catheter body (6). The limiting block (83) is fixedly connected to the inner wall of the protective sleeve (85) facing the catheter body (6). One end of the protective sleeve (85) is located on the side of the inner support (82) away from the second balloon (73), and the protective sleeve (85) is connected to the third balloon (87). One end is fixedly connected, and the other end of the protective tube (85) passes through the third balloon (87) and is slidably connected to the third balloon (87). A fixing ring (84) is fixedly connected to the side of the protective tube (85) away from the third balloon (87). A circular arc protrusion is provided on the edge of the end face of the drug placement plate (74) away from the catheter body (6). The fixing ring (84) abuts against the circular arc protrusion. The end of the third balloon (87) near the inner stent (82) is fixedly connected to the inner stent (82), and the third balloon (87) is connected to the third suction pipe (86) through the third suction branch (88). The protective mechanism (8) further includes an outer support (81), a fourth balloon (89), and a fourth suction pipe (811). The outer support (81) is located on the side of the inner support (82) away from the second balloon (73). The fourth balloon (89) is fixedly connected to the side of the outer support (81) away from the catheter body (6). The end of the fourth balloon (89) away from the outer support (81) is fixedly connected to the protective cylinder (85). The fourth balloon (89) is connected to the fourth suction pipe (811) through the fourth suction branch pipe (810).

2. The balloon catheter for targeted drug release according to claim 1, characterized in that, A handle (5) is fixedly connected to one end of the circumferential surface of the catheter body (6). A tip (1) is provided at the end of the catheter body (6) away from the handle (5). A connector (4) is fixedly installed on the handle (5). A first inner lumen (2) and a second inner lumen (9) are respectively opened in the catheter body (6). The first inner lumen (2) extends along the setting direction of the catheter body (6), and the end of the first inner lumen (2) away from the tip (1) penetrates the catheter body (6). The first inner lumen (2) is used to push the guide wire. The second inner lumen (9) extends along the setting direction of the catheter body (6). A through groove is opened in the connector (4), and the end of the second inner lumen (9) away from the tip (1) is connected to the through groove. The second suction branch tube (72) passes through the catheter body (6) to the second inner lumen (9), and the second suction branch tube (72) is fixedly connected to the catheter body (6). The end of the second suction branch tube (72) away from the second balloon (73) is connected to the second suction pipe (71). The second suction pipe (71) passes through the second inner lumen (9) and the through groove. One end of the third suction branch (88) is fixedly connected to the third balloon (87), and the other end of the third suction branch (88) is fixedly connected to the third suction pipe (86). The third suction branch (88) passes through the catheter body (6) to the second inner lumen (9), and the third suction branch (88) is fixedly connected to the catheter body (6). The third suction pipe (86) passes through the second inner lumen (9) and the through groove.

3. The balloon catheter for targeted drug release according to claim 1, characterized in that, The telescopic assembly includes a sleeve (76) and a guide post (77). One end of the sleeve (76) is fixedly connected to the catheter body (6), and the other end of the sleeve (76) is slidably connected to the guide post (77). The end of the guide post (77) away from the sleeve (76) is fixedly connected to the drug placement plate (74).

4. The balloon catheter for targeted drug release according to claim 1, characterized in that, The catheter body (6) is fixedly connected to a contrast ring (3) on the circumferential wall between the inner stent (82) and the second balloon (73). The contrast ring (3) is used to locate the drug release position.

5. A balloon catheter for targeted drug release according to claim 1, characterized in that, The external support (81) is fixedly connected to the catheter body (6), the fourth suction branch (810) passes through the catheter body (6) to the second inner lumen (9), one end of the fourth suction branch (810) is fixedly connected to the fourth balloon (89), the other end of the fourth suction branch (810) is fixedly connected to the fourth suction pipe (811), and the fourth suction branch (810) is fixedly connected to the catheter body (6), and the fourth suction pipe (811) passes through the second inner lumen (9) and the through groove; When the drug delivery plate (74) is in the drug delivery position, the fourth balloon (89) inflates; when the drug delivery plate (74) is in the drug feeding position, the fourth balloon (89) contracts.

6. A balloon catheter for targeted drug release according to claim 3, characterized in that, The drug feeding mechanism (7) further includes a guide rod (711), a wedge (713), a compression plate (712), a first suction branch pipe (78), and a first suction pipe (710). One end of the guide rod (711) is fixedly connected to the side end of the drug placement plate (74), and the other end of the guide rod (711) is slidably connected in the guide groove (717). The guide groove (717) is opened in the adjacent drug placement plate (74). The guide rod (711) has an arc-shaped protrusion. Along the radial direction of the catheter body (6), the lowest point of the arc-shaped protrusion of the guide rod (711) is close to the opening of the guide groove (717), and the highest point of the arc-shaped protrusion of the guide rod (711) is far away from the guide groove (710). At the opening position of 17), the arcuate protrusion of the guide rod (711) presses against the wedge (713). The end of the wedge (713) away from the guide rod (711) is fixedly connected to a pressing plate (712). The pressing plate (712) is slidably connected in the drug placement cavity (716). The drug placement cavity (716) is opened in the drug placement plate (74). A spring (714) is sleeved on the side wall of the wedge (713) between the drug placement cavity (716) and the pressing plate (712). One end of the spring (714) is fixedly connected to the inner wall of the drug placement cavity (716), and the other end of the spring (714) is fixedly connected to the pressing plate (712). The side of the pressing plate (712) is pressed against the drug placement cavity (716). 6) The inner wall is sealed and fits tightly, dividing the drug placement chamber (716) into two areas. The area on the side of the drug placement chamber (716) away from the wedge block (713) from the extrusion plate (712) is the drug placement area. The drug placement area of ​​the drug placement chamber (716) is connected to the drug placement groove (75) through the through hole (715). A connecting branch pipe (79) is fixedly connected to the side wall of the drug placement chamber (716) near the through hole (715). One-way valves are installed at the connection point between the connecting branch pipe (79) and the drug placement chamber (716) and in the through hole (715), respectively. The one-way valve installed at the connection point between the connecting branch pipe (79) and the drug placement chamber (716) and the one-way valve installed in the through hole (715) are connected in the same direction. Conversely, the other end of the connecting branch (79) is connected to the drug placement cavity (716) in the adjacent drug placement plate (74). The connecting branch (79) is used to connect the drug placement cavity (716) in the adjacent drug placement plate (74). The connecting branch (79) is connected to the first suction pipe (710) through the first suction branch (78). One end of the first suction branch (78) is fixedly connected to the connecting branch (79). The other end of the first suction branch (78) passes through the catheter body (6) to the second inner lumen (9). The first suction branch (78) is fixedly connected to the first suction pipe (710). The first suction branch (78) is fixedly connected to the catheter body (6). When the drug delivery plate (74) is in the drug delivery position, the guide rod (711) is in the initial position, and the squeezing plate (712) is located at one end of the drug delivery cavity (716) near the wedge (713); When the drug-feeding plate (74) is in the drug feeding position, the guide rod (711) moves to the maximum displacement along the extension direction of the guide groove (717), and the squeezing plate (712) moves to the maximum displacement away from the wedge (713).

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