Split type double-chamber gas pressure balanced medicine liquid transfer device

Abstract

The application discloses a split type double-chamber gas pressure balanced medicine liquid transfer device, which comprises a component I and a component II, wherein the component I comprises a first syringe, a first needle seat and a medicine injection needle assembly, the component II comprises a second syringe, a second needle seat and a puncture needle fixedly connected to the second needle seat; in a fixed connection state of the component I and the component II, the puncture needle of the component II penetrates a sealing plug in a gas window of the component I and is in communication with a second channel in the first needle seat. The further improved medicine liquid transfer device can be conveniently applied to a bolus injection device to quantitatively transfer medicine liquid on the basis of retaining the characteristics of airtightness and gas pressure balance.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of medical dispensing pipetting devices, in particular to a split type double-chamber gas pressure balanced liquid medicine transfer device. BACKGROUND

[0002] Dangerous drugs represented by chemotherapy drugs pose a great threat to the health of medical staff who are engaged in the preparation and transportation of such drugs for a long time. Some medical institutions have built various purification rooms, biological cabinets and other facilities to reduce the risk of drug leakage, but the actual promotion and application effect is not good.

[0003] A double-chamber internal circulation closed liquid medicine transfer device and system are disclosed in Chinese patent CN115607444B (CN202211220305.4). The drug dispensing device is provided with a double-chamber syringe, one chamber of which is used for infusion liquid, and the other chamber is used for balancing gas pressure, effectively ensuring the airtightness of the drug dispensing process and reducing the risk of leakage.

[0004] Another application of the liquid medicine transfer device (i.e. drug dispenser) is to realize quantitative drug supply as a drug supply source in a drug supply equipment. Generally, after the drug is prepared, the drug dispenser needs to be installed on a bolus device (such as the WZS-50F6 bolus device of Medfusion, and the SYS-52 bolus device of MEDCAPTAIN) that can control the infusion volume / infusion speed. The bolus device can fix the injection barrel of the drug dispenser, and can also push the piston rod to move at a predetermined speed, thereby realizing quantitative infusion. If the double-chamber syringe is directly installed on the bolus device, both piston rods will be pushed, making the bolus device unable to work, or occupying space and affecting the normal operation of other accessories. SUMMARY

[0005] In view of the problem that the new drug dispenser cannot be applied to the existing bolus device, the purpose of the present application is to provide a split type double-chamber gas pressure balanced liquid medicine transfer device. The further improved liquid medicine transfer device can be conveniently applied to the bolus device for quantitative liquid medicine transmission while retaining the characteristics of airtightness and gas pressure balance.

[0006] To achieve the above purpose, the present application adopts the following technical solutions.

[0007] A split type double-chamber gas pressure balanced liquid medicine transfer device includes component I and component II, wherein:

[0008] Component I includes a first syringe, a first needle seat, and a dispensing needle assembly, wherein the first needle seat is connected and fixed with the first syringe through a joint on the first syringe, and the dispensing needle assembly is fixedly connected to the first needle seat;

[0009] The first needle seat is internally provided with a first channel and a second channel, is provided with an air window on the side surface, and is provided with a cavity at the end for connecting and fixing with the connector on the first syringe; the end of the first channel is in communication with the cavity, and the end of the second channel is in communication with the air window; the air window is internally provided with a sealing plug;

[0010] The drug delivery needle assembly comprises a liquid delivery channel and an air exhaust channel, wherein the liquid delivery channel is in communication with the first channel, and the air exhaust channel is in communication with the second channel;

[0011] The assembly II comprises a second syringe, a second needle seat, and a puncture needle fixedly connected to the second needle seat.

[0012] When the assembly I and the assembly II are fixedly connected, the puncture needle of the assembly II penetrates the sealing plug in the air window of the assembly I and realizes communication with the second channel in the first needle seat.

[0013] When the assembly I and the assembly II are separated, the sealing plug in the air window makes the air window in a sealed state.

[0014] In the present application, unless otherwise specified, when the structure of the assembly is described, the front end refers to the end to which the tip of the drug delivery needle and / or the puncture needle points, and the rear end (or the end) refers to the other end opposite to it.

[0015] The structure of the syringe is easily known and determined by those skilled in the art, and generally comprises a syringe barrel and a piston rod which can slide back and forth in the inner cavity of the syringe barrel. Specifically, the first syringe comprises a first syringe barrel and a first piston rod which can slide back and forth in the inner cavity of the first syringe barrel; the second syringe comprises a second syringe barrel and a second piston rod which can slide back and forth in the inner cavity of the second syringe barrel.

[0016] Preferably, when the assembly I and the assembly II are fixedly connected, the first syringe barrel and the second syringe barrel are fixedly connected in a side-by-side and same-direction manner. Further preferably, at least one of the first syringe barrel and the second syringe barrel is provided with a buckle structure on the outer wall, so that the first syringe barrel and the second syringe barrel can be detachably fixed to each other when arranged in a side-by-side and same-direction manner. More preferably, at least one of the first syringe barrel and the second syringe barrel is provided with a support portion on the barrel wall, and the end structure of the support portion matches the outer side wall of the opposite syringe barrel, so that the first syringe barrel and the second syringe barrel can be supported by the support portion when arranged in a side-by-side and same-direction manner.

[0017] In the split type double-chamber air pressure balanced drug liquid transfer device of the present application, the assembly I comprises a first syringe, a first needle seat, and a drug delivery needle assembly.

[0018] The end of the second channel communicates with the air window inside the first needle seat. When the piercing needle of the assembly II pierces the sealing plug inside the air window of the assembly I, the second channel communicates with the second syringe through the piercing needle tube; when the assembly I and the assembly II are separated, the sealing plug inside the air window can make the air window in a sealed state, isolated from the outside world.

[0019] Preferably, a pass-stop module for controlling the pass or stop of the second channel is arranged in the second channel of the first needle seat, to further ensure the sealing of the second channel relative to the outside world. As an embodiment, the pass-stop module is a rotatable pass-stop valve, with a through hole arranged in the valve; the pass-stop valve is rotated to make the through hole in register or out of register with the second channel, to conveniently realize the pass or stop of the two channels. As another embodiment, the pass-stop module is a control valve, which comprises a sliding block and a sliding groove arranged through the second channel in the radial direction of the first needle seat, the sliding block being slidably arranged in the sliding groove, and a through hole being arranged in the sliding block; when the sliding block is slid to a preset position, the two ends of the through hole are respectively butted against the second channel, and when the sliding block is slid out of the preset position, the outer side of the sliding block stops the second channel.

[0020] As a preferred embodiment, the first needle seat is radially provided with a protruding portion on the side close to the second channel, and the air window is arranged at the end of the protruding portion. Further preferably, the length of the protruding portion exceeds the radius of the first syringe barrel.

[0021] The sealing plug is made of an elastic material, preferably any one of rubber, silicone and synthetic rubber. The applicable elastic material should meet the relevant standards of medical materials, which is easy to know and determine for those skilled in the art.

[0022] The dispensing needle assembly comprises an infusion channel and an exhaust channel, wherein the infusion channel communicates with the first channel, and the exhaust channel communicates with the second channel.

[0023] As an embodiment, the dispensing needle assembly is composed of a first needle tube and a second needle tube arranged in parallel and fixedly connected to the first needle seat by embedding the rear ends. The inner cavity of the first needle tube constitutes the infusion channel, and the rear end port communicates with the first channel; the inner cavity of the second needle tube constitutes the exhaust channel, and the rear end port communicates with the second channel. Particularly preferably, the first needle tube, the first channel and the first syringe are coaxially arranged.

[0024] In another embodiment, the dispensing needle assembly has a double-layered columnar structure, comprising an inner column channel and a side ring channel, one of which serves as an infusion channel and the other as an exhaust channel. Preferably, the dispensing needle assembly comprises an inner needle tube and an outer needle tube, with the inner needle tube inserted within the outer needle tube and extending beyond the outer needle tube at both ends. In this case, the inner column channel is formed by the inner cavity of the inner needle tube, and the side ring channel is formed by the cavity between the outer and inner needle tubes. The inner and outer needle tubes can be independent of each other or integrally formed and fixedly connected. In the latter case, the front end of the outer needle tube is preferably sealed and fixedly connected to the front side wall of the inner needle tube. Further preferably, the front end of the inner needle tube is configured as an oblique opening, or the front end of the inner needle tube is pointed and provided with a side opening, while the front side wall of the outer needle tube is provided with a side opening. Such an opening design not only facilitates the dispensing needle's insertion into the container but also reduces interference between the inner column channel and the side ring channel. In one specific embodiment, a double-layered cylindrical dispensing needle assembly, a first channel, and a first syringe are coaxially arranged. The inner column channel formed by the inner lumen of the inner needle tube serves as the infusion channel, and the side ring channel formed by the cavity between the outer and inner needle tubes serves as the exhaust channel. In another specific embodiment, in a double-layered cylindrical dispensing needle assembly, the inner column channel formed by the inner lumen of the inner needle tube serves as the exhaust channel, and the side ring channel formed by the cavity between the outer and inner needle tubes serves as the infusion channel.

[0025] Preferably, the assembly 1 further comprises a needle sealing assembly, the needle sealing assembly comprising a first sleeve, a first sealing member and a first elastic member arranged coaxially with the first needle seat; wherein:

[0026] The first sleeve is a hollow cylindrical structure with front and rear openings, and is axially movably sleeved on the front end of the first needle seat;

[0027] The first sealing member is made of elastic material and is fixedly arranged in the front end cylinder of the first sleeve; a hole for the needle tube to pass through is provided in the first sealing member, and the inner diameter of the hole is smaller than the outer diameter of the needle tube;

[0028] The first elastic member is arranged between the first sealing member and the first needle seat, and relies on the needle seat to provide axial elastic support for the first sealing member at the front end;

[0029] In the non-pressurized state, the first elastic member stretches axially, the first sleeve shields the needle tube inside the sleeve, and under the elastic force of the elastic material, the first sealing member tightly wraps the front end of the needle tube, sealing the front end openings of the infusion channel and the exhaust channel;

[0030] Under pressure, the first elastic member is axially compressed, and the front end of the needle tube including the front end channel openings of the infusion channel and the exhaust channel can pass through the hole of the first sealing member and out of the first sleeve.

[0031] The needle sealing assembly not only has the function of preventing the needle from being stabbed, but also ensures that the liquid medicine preparation and transfer process are in a fully closed state, thereby avoiding the risk of liquid medicine leakage from the front channel port. Components with similar structures and functions have been reported in the applicant's prior patents, such as CN115607444B, which is incorporated herein in its entirety.

[0032] As a preferred embodiment of the present application, the needle sealing assembly comprises a coaxially arranged first sleeve, a first sealing member, a first elastic member and an inner sleeve, wherein:

[0033] The front end of the first sleeve has a smaller inner diameter, forming a composite cylindrical structure composed of a first cylinder segment with a smaller inner diameter and a second cylinder segment with a larger inner diameter;

[0034] The first sealing member is designed as a structure with an inverted T-shaped cross section, the front diameter corresponds to the inner diameter of the first cylinder segment, and the rear diameter corresponds to the inner diameter of the second cylinder segment, so that the first sealing member can fill at least part of the second cylinder segment lumen while completely filling the first cylinder segment lumen;

[0035] The inner diameter of the inner sleeve corresponds to the outer diameter of the first needle seat, and the outer diameter of the inner sleeve corresponds to the inner diameter of the second cylinder segment of the first sleeve, the front end face is closed and has a through hole for the needle tube to pass through; the inner sleeve is fixedly connected to the second cylinder segment of the first sleeve, and the front end face abuts against the rear end face of the first sealing member;

[0036] The first elastic member is arranged in the inner sleeve, and the two ends thereof abut against the front end inner surface of the inner sleeve and the front end face of the first needle seat, respectively.

[0037] By improving the structure of the first sleeve and the first sealing member and adding the inner sleeve, the first sealing member is limited and fixed, and the front and rear ends of the first elastic member abut against hard materials, and the overall structure and performance are more stable. Further preferably, the outer wall of the inner sleeve is provided with a buckle, and the second cylinder segment of the first sleeve is provided with a corresponding buckle hole, and the fixed connection between the first sleeve and the inner sleeve is realized by the cooperation of the buckle and the buckle hole when the inner sleeve is inserted into the first sleeve. Preferably, the rear end of the inner sleeve is provided with a ring-shaped boss in a radially outward manner, and when the front end face of the inner sleeve abuts against the rear end face of the first sealing member, the ring-shaped boss at the rear end is exposed to the first sleeve and abuts against the rear end of the first sleeve.

[0038] It is easily understood that, in the process of using the drug solution transfer device, the needle sealing assembly will move axially with the expansion and contraction of the first elastic member, but it always remains connected with the first needle seat. As a preferred embodiment, the front end inner surface of the inner sleeve and the front end surface of the first needle seat are both provided with a buckle structure, thereby realizing the fixed connection with the first elastic member. As another preferred embodiment, the side surface of the first needle seat is provided with an L-shaped groove composed of an axial groove and a transverse groove (perpendicular to the axial groove), and the rear end of the inner sleeve is radially provided with a sliding table which is embedded in the L-shaped groove and can slide along the groove. Through the position design of the sliding table and the L-shaped groove, the activity range of the needle sealing assembly relative to the first needle seat can be flexibly adjusted and limited. With the sliding table sliding backward along the axial groove, the first elastic member is compressed and the needle tube penetrates through the first sealing member, and when reaching a certain degree, the sliding table is rotated along the transverse groove, thereby limiting the axial movement of the needle sealing assembly, so as to achieve the effect of limiting and fixing.

[0039] The first sealing member is made of an elastic material, preferably any one of rubber, silicone and synthetic glue. The applicable elastic material should meet the relevant standards of medical materials, which is easily known and determined by those skilled in the art. As a preferred embodiment, the front end surface of the first sealing member protrudes out of the front end surface of the first sleeve, thereby when preparing and transferring the drug solution, the sealing member made of elastic material can be attached to the rubber port of the container, so as to better seal the opening of the container.

[0040] The first elastic member can be an elastic folding tube, a spring or the like, and is preferably a spring.

[0041] It is easily understood that, for the purpose of better connection with infusion tubes, medicine bottles, bolus devices and the like, the front end of the first sleeve is preferably provided with a fixed connection structure (such as a rotating buckle structure and the like) adapted to the pipette connector, so as to be fixedly connected with the connector. The pipette connector is easily understood by those skilled in the art, and a large number of similar structures have been reported in the prior art, and its function mainly lies in realizing the auxiliary fixed connection between the drug solution transfer device and the infusion tube interface, the medicine bottle port or other equipment liquid inlet; preferably, the pipette connector is provided at one end corresponding to the drug solution transfer device with a sealing member (such as a rubber plug) which can be pierced by the needle tube, so as to better play the sealing function in the process of infusion or drug solution transfer.

[0042] The assembly II includes a second syringe, a second needle seat and a puncture needle fixedly connected to the second needle seat. In the fixed connection state of the assembly I and the assembly II, the puncture needle of the assembly II pierces the sealing plug in the air window of the assembly I, and realizes the communication with the second channel in the first needle seat.

[0043] It is easily understood that the structure of the second needle seat and the puncture needle in the assembly II should correspond to the structure of the air window in the assembly I. Preferably, when the first needle seat is provided with a protrusion radially on the side close to the second channel, and the air window is arranged at the end of the protrusion, the second needle seat and the puncture needle in the assembly II are arranged in a manner perpendicular to the second syringe, and when the first syringe and the second syringe are fixedly connected in a side-by-side and same-direction manner, the puncture needle transversely penetrates the sealing plug to realize communication with the second channel in the first needle seat.

[0044] In order to realize better system sealing, preferably, the assembly II further comprises a puncture needle sealing assembly, the puncture needle sealing assembly comprising a second sleeve coaxially arranged with the puncture needle, a second sealing member and a second elastic member; wherein,

[0045] The second sleeve is a hollow cylindrical structure with an open front end, and the rear end is fixedly connected to the second needle seat;

[0046] The second sealing member is made of elastic material and is fixedly arranged in the front end cylinder of the second sleeve; the second sealing member is provided with a hole for the puncture needle to pass through, and the inner diameter of the hole is smaller than the outer diameter of the puncture needle;

[0047] The second elastic member is arranged between the second sealing member and the second needle seat and relies on the needle seat to provide axial elastic support for the front end of the second sealing member;

[0048] In the non-pressurized state, the second elastic member is axially stretched, the second sleeve shields the puncture needle inside the sleeve, and under the elastic force of the elastic material, the second sealing member tightly wraps the front end of the puncture needle and closes the puncture needle opening inside;

[0049] In the pressurized state, the second sealing member slides to the rear end, the second elastic member is axially compressed, and the front end of the puncture needle penetrates out of the second sealing member.

[0050] Further preferably, the puncture needle sealing assembly further comprises a sliding sleeve coaxially arranged with the puncture needle. The sliding sleeve is a hollow cylindrical structure with open front and rear ends, arranged in the second sleeve, with an outer diameter matched with the inner diameter of the second sleeve, and can slide axially forward and backward in the second sleeve, and the second sealing member is filled in the sliding sleeve. More preferably, the sliding sleeve is designed as a composite cylindrical structure composed of a front cylinder segment with a larger inner diameter and a rear cylinder segment with a smaller inner diameter; correspondingly, the second sealing member is designed as a T-shaped structure in cross section, so that the second sealing member can completely fill the inner cavity of the sliding sleeve.

[0051] In order to prevent the second sealing member or the sliding sleeve filled with the second sealing member from moving out of the second sleeve, a limiting structure is preferably arranged at the front end of the second sleeve, such as a radially inward protrusion.

[0052] The second sealing member is made of an elastic material, preferably any one of rubber, silicone, and synthetic rubber. The applicable elastic material should meet the relevant standards of medical materials, which is easy to know and determine for those skilled in the art. The second elastic member can be an elastic folding tube, a spring, etc., preferably a spring.

[0053] As a preferred embodiment of the drug solution transfer device, the first needle seat in assembly I is provided with a protruding portion on the side close to the second channel, and the air window is arranged at the end of the protruding portion; the second needle seat, the puncture needle, and the puncture needle sealing assembly in assembly II are arranged in a manner perpendicular to the second syringe; when the first syringe and the second syringe are fixedly connected in a side-by-side and same-direction manner, the air window provided with the sealing plug is inserted into the second sleeve and pushes the second sealing member or the sliding sleeve filled with the second sealing member to slide to the rear end, the second elastic member is axially compressed, the front end of the puncture needle penetrates through the second sealing member and pierces the sealing plug, and the second channel in the first needle seat is in communication. Further preferably, the front end of the second sleeve is provided with a fixed clamping structure, and the protruding portion of the first needle seat is provided with a fixed clamping groove matched with the fixed clamping structure; when assembly I and assembly II are fixedly connected, the fixed clamping structure and the fixed clamping groove are fixed to each other.

[0054] The drug solution transfer device has the characteristics of double-chamber internal circulation. After assembly I and assembly II are fixedly and airtightly connected, the infusion channel, the first channel, the cavity of the first needle seat, and the first syringe are sequentially connected from front to back to form airtight passage I; the exhaust channel, the second channel, the puncture needle tube, and the second syringe are sequentially connected from front to back to form airtight passage II. The airtight passage I and the airtight passage II are independent of each other. During the preparation and transfer of the drug solution, the airtight passage I is used for transmitting the drug solution, and the airtight passage II plays a role in transmitting gas and balancing gas pressure. The drug solution transfer device can be used for the purposes of preparing mixed medicaments, transferring the prepared drug solution into an infusion bottle or a retention needle or a bolus device, etc. Based on a full understanding of the structure of the above-mentioned drug solution transfer device of the present application, how to use it to prepare and transfer the drug solution is easy to determine for those skilled in the art, for example, see the applicant's prior patent CN115607444B, which is incorporated herein in its entirety.

[0055] Correspondingly, the present application also relates to the application of the drug solution transfer device in quantitative infusion; and a quantitative infusion device comprising the drug solution transfer device.

[0056] It is easy to understand that, similar to the double-chamber internal circulation closed liquid medicine transfer device in CN115607444B, the liquid medicine transfer device of the present application also has the following excellent effects: (1) The structure design is exquisite, each component is a component that is convenient for batch production and assembly, without the use of relatively complex components, without the use of special equipment. (2) The structure and performance of the product are stable, the cost is low but the yield is high, and the use is convenient. (3) During the preparation and transfer of the medicine, the internal and external air pressure of the liquid medicine transfer system is completely balanced. (4) The preparation and transfer of the medicine can be completely closed, the risk of medicine leakage is maximized, and the sealing effect is very excellent.

[0057] Not only that, the present application can also solve the problem that the new double-chamber type medicine dispenser cannot be used with the existing bolus injection device. The biggest improvement is that the liquid medicine transfer device of the present application is designed as a split type. After the user prepares the liquid medicine (the liquid medicine is in the first syringe), the user can conveniently separate the component I and the component II. At this time, the sealing plug reseals the second channel, and the component I can be very conveniently installed on the bolus injection device to perform quantitative liquid medicine transmission. BRIEF DESCRIPTION OF DRAWINGS

[0058] Figure 1 It is a cross-sectional structure schematic diagram of the liquid medicine transfer device of Example 1 in a split state.

[0059] Figure 2 It is a cross-sectional structure schematic diagram of the liquid medicine transfer device of Example 1 in an assembled state.

[0060] Figure 3 It is a cross-sectional structure schematic diagram of the liquid medicine transfer device of Example 2 in an assembled state.

[0061] Figure 4 It is a use state schematic diagram of the component I in the liquid medicine transfer device of Example 2 connected to the dosing pump.

[0062] Figure 5 It is a cross-sectional structure schematic diagram of the liquid medicine transfer device of Example 3 in an assembled state.

[0063] Figure 6 is a representative physical diagram of a liquid medicine transfer device.

[0064] Figure 7 It is a use state schematic diagram of the component I in the liquid medicine transfer device of Example 3 on the single-channel quantitative bolus injector.

[0065] Figure 8 It is a cross-sectional structure schematic diagram of the liquid medicine transfer device of Example 4 in a split state.

[0066] Figure numerals: first syringe 1, first syringe 11, first piston rod 12, connector 13, first needle seat 2, first channel 21, second channel 22, protrusion 23, air window 24, sealing plug 25, on-off valve 26, fixed card slot 27, cavity 28, dispensing needle assembly 3, first needle tube 31, second needle tube 32, second syringe 4, second syringe 41, second piston rod 42, snap structure 43, support portion 44, second needle seat 5, puncture needle 6, puncture needle sealing assembly 7, second sleeve 71, sliding sleeve 72, second sealing member 73, second elastic member 74, fixed snap structure 75, needle sealing assembly 8, first sleeve 81, first sealing member 82, inner sleeve 83, first elastic member 84, pipetting connector 9, chemical pump 10, capsule 101. DETAILED DESCRIPTION

[0067] In order to better illustrate the purpose, technical solutions and advantages of the present invention, the specific embodiments of the present invention are described in further detail below in conjunction with the accompanying drawings and examples. The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention.

[0068] Example 1

[0069] like Figure 1 As shown, a split-type dual-chamber air pressure balanced liquid medicine transfer device of the present invention comprises a component I and a component II. The liquid medicine transfer device is in a split state, and the components I and II are not fixedly connected.

[0070] Assembly I consists of a first syringe 1, a first needle seat 2 and a dispensing needle assembly 3.

[0071] The first syringe 1 comprises a first syringe barrel 11 , a first piston rod 12 slidable forward and backward along an inner cavity of the first syringe barrel 11 , and a connector 13 provided at a front end.

[0072] The first needle hub 2 is provided with a first channel 21 and a second channel 22 inside, and a protrusion 23 is radially provided on one side near the second channel 22. The length of the protrusion 23 exceeds the radius of the first syringe 11, and an air window 24 is provided at the end of the protrusion 23. The end of the first needle hub 2 is provided with a cavity 28 for connecting and fixing with the connector 13 on the first syringe 1. The end of the first channel 21 is connected to the cavity 28, and the end of the second channel 22 is connected to the air window 24. A sealing plug 25 made of elastic medical silicone is fixedly provided in the air window 24 in an interference fit manner. The sealing plug 25 keeps the air window 24 in a sealed state and isolates it from the outside world.

[0073] By inserting the connector 13 on the first syringe 1 into the cavity 28 at the end of the first needle seat 2 , the first needle seat 2 is connected and fixed to the first syringe 1 .

[0074] The dispensing needle assembly 3 is composed of a first needle tube 31 and a second needle tube 32 which are fixedly connected in parallel and embedded at the rear end on the first needle seat 2. The inner cavity of the first needle tube 31 constitutes a transfusion channel, and the rear end port is in communication with the first channel 21; the inner cavity of the second needle tube 32 constitutes an exhaust channel, and the rear end port is in communication with the second channel 22. The first needle tube 31, the first channel 21 and the first syringe 1 are coaxially arranged.

[0075] The assembly II includes a second syringe 4, a second needle seat 5, a puncture needle 6 fixedly connected on the second needle seat 5, and a puncture needle sealing assembly 7.

[0076] The second syringe 4 includes a second syringe barrel 41 which has the same size specification as the first syringe barrel 11, and a second piston rod 42 which can slide forward and backward along the inner cavity in the second syringe barrel 41. A support part 44 is arranged on the barrel wall of the second syringe barrel 41, and the end structure of the support part 44 matches the outer side wall of the first syringe barrel 11, so that the first syringe barrel 11 and the second syringe barrel 41 can support each other through the support part 44 when they are arranged side by side and in the same direction, achieving better fixing effect. A buckle structure 43 is arranged on the outer wall of the end of the second syringe barrel 41, so that the first syringe barrel 11 and the second syringe barrel 41 can be detachably fixed to each other when they are arranged side by side and in the same direction.

[0077] The structure of the second needle seat 5 and the puncture needle 6 corresponds to the structure of the air window 24 in the assembly I. Specifically, the second needle seat 5 and the puncture needle 6 are arranged perpendicularly to the second syringe barrel 41, and when the first syringe barrel 11 and the second syringe barrel 41 are fixedly connected in a side-by-side and same-direction manner, the puncture needle 6 can transversely pierce the sealing plug 25 to realize communication with the second channel 22 in the first needle seat 2.

[0078] The puncture needle sealing assembly 7 includes a second sleeve 71 coaxially arranged with the puncture needle 6, a sliding sleeve 72, a second sealing member 73 and a second elastic member 74.

[0079] The second sleeve 71 is a hollow cylindrical structure with an open front end, and the rear end is fixedly connected on the second needle seat 5.

[0080] The sliding sleeve 72 is a hollow cylindrical structure with open front and rear ends, and is designed as a composite cylindrical structure composed of a front part with a larger inner diameter and a rear part with a smaller inner diameter. The sliding sleeve 72 is arranged in the second sleeve 71, and the outer diameter thereof is adapted to the inner diameter of the second sleeve 71, so that it can slide axially forward and backward in the second sleeve 71.

[0081] The second sealing member 73 is made of elastic medical-grade silicone, and is designed as a structure with a T-shaped cross section, which completely fills the inner cavity of the sliding sleeve 72. The second sealing member 73 is provided with a hole for the puncture needle 6 to pass through, and the inner diameter of the hole is smaller than the outer diameter of the puncture needle 6.

[0082] The second elastic member 74 is a spring, which is arranged between the sliding sleeve 72 and the second needle seat 5. Relying on the needle seat 5, the second elastic member 74 provides axial elastic support for the front end sliding sleeve 72. Figure 1 As shown in the figure, in the non-pressurized state, the second elastic member 74 stretches axially, the second sleeve 71 shields the puncture needle 6 inside the sleeve, and under the elastic force of the elastic material, the second sealing member 73 tightly wraps the front end of the puncture needle 6 and seals the puncture needle opening inside.

[0083] To prevent the sliding sleeve 72, filled with the second sealing member 73, from moving outside the second sleeve 71, a radially inwardly facing boss is provided at the front end of the second sleeve 71 to provide a position limiter. Furthermore, a fixed snap-fit ​​structure 75 is provided at the front end of the second sleeve 71. This fixed snap-fit ​​structure 75 mates with the fixed snap-fit ​​groove 27 provided on the raised portion 23 of the first needle hub 2. When assemblies I and II are fixedly connected, the fixed snap-fit ​​structure 75 and the fixed snap-fit ​​groove 27 are mutually connected and fixed.

[0084] Figure 2 The figure shows the liquid medicine transfer device with components I and II fixedly connected. The first and second syringes 11 and 41 are fixedly connected side by side and in the same direction. The air vent 24, which houses the sealing plug 25, is inserted into the second sleeve 71 and pushes the sliding sleeve 72, which is filled with the second sealing member 73, to slide rearward. The second elastic member 74 is axially compressed, allowing the leading end of the puncture needle 6 to pass through the second sealing member 73 and pierce the sealing plug 25, establishing communication with the second channel 22 in the first needle holder 2. Simultaneously, the fixed snap structure 75 is fixedly connected to the fixed slot 27.

[0085] like Figure 2 As shown, after Components I and II are fixed and sealed together, the infusion channel, first channel 21, cavity 28 of first needle holder 2, and first syringe 11 are connected in sequence from front to back, forming closed passage I. The exhaust channel, second channel 22, puncture needle tube, and second syringe 41 are connected in sequence from front to back, forming closed passage II. Closed passages I and II are independent of each other. During the preparation and transfer of liquid medicine, closed passage I is used to transport liquid medicine, while closed passage II is used to transport gas and balance air pressure.

[0086] Example 2

[0087] Figure 3 The figure shows another type of split dual-chamber pressure-balanced liquid medicine transfer device of the present invention. Compared with the liquid medicine transfer device of Example 1, the main difference is that the component 1 also includes a needle sealing component 8.

[0088] The needle sealing assembly 8 includes a first sleeve 81 , a first sealing member 82 , an inner sleeve 83 and a first elastic member 84 , which are coaxially arranged with the first needle seat 2 .

[0089] The front end of the first sleeve 81 has a smaller inner diameter, forming a composite cylindrical structure consisting of a first section with a smaller inner diameter and a second section with a larger inner diameter. Two snap-fit ​​structures are symmetrically positioned on the front outer surface of the first section to facilitate secure connection with the pipette connector. The second section has two symmetrical snap-fit ​​holes on its wall near the rear port.

[0090] The first sealing member 82 is made of elastic medical-grade silicone and has an inverted T-shaped cross-section. Its front diameter is equal to the inner diameter of the first barrel section and its length is slightly longer than the axial length of the first barrel section. Its rear diameter is equal to the inner diameter of the second barrel section. While completely filling the inner cavity of the first barrel section and the inner cavity at the front end of the second barrel section, the front end of the first sealing member 82 protrudes beyond the front end of the first sleeve 81. A passageway for the first and second needle tubes 31, 32 is provided within the first sealing member 82. The inner diameter of the passageway is smaller than the outer diameter of the needle tubes.

[0091] The inner diameter and outer diameter of the inner sleeve 83 correspond to the outer diameter of the first needle seat 2 and the inner diameter of the second barrel section of the first sheath 81 respectively. The front end face is closed and a through hole for the first needle tube 31 and the second needle tube 32 to pass through is provided on the end face. The rear port is provided with an annular boss in a radially outward manner, and two buckles matching the clamping holes are symmetrically provided on the outer wall adjacent to the rear port.

[0092] The inner sleeve 83 is inserted into the second barrel section of the first sleeve 81, and a fixed connection between the two is achieved through the cooperation of the buckle and the card hole. At the same time, the front end face of the inner sleeve 83 abuts against the rear end face of the first sealing part 82, and the annular boss at the rear end is exposed in the first sleeve 81 and abuts against the rear end of the first sleeve 81.

[0093] The first elastic member 84 is a spring, which is disposed in the inner sleeve 83 , with its two ends respectively abutting against the front inner surface of the inner sleeve 83 and the front end surface of the first needle seat 2 .

[0094] The side of the first needle seat 2 is symmetrically provided with two L-shaped grooves consisting of an axial groove and a transverse groove. Correspondingly, the rear end of the inner sleeve 83 is symmetrically provided with two slides radially inward, which are embedded in the L-shaped grooves and can slide along the grooves.

[0095] like Figure 3 As shown, the needle sealing assembly 8 of component I is in a non-pressurized state, the first elastic member 84 is axially extended, the slide of the inner sleeve 83 is located at the front end of the axial groove on the side of the first needle seat 2, the first sheath 81 shields the first needle tube 31 and the second needle tube 32 inside the first sheath 81, and under the elastic force of the silicone, the first sealing member 82 tightly wraps the front end of the first needle tube 31 and the second needle tube 32, sealing the front end channel openings of the infusion channel and the exhaust channel.

[0096] The drug solution transfer device of the present application is designed as a split type. After the drug solution is prepared (in the first syringe 11), the user can conveniently separate the component I and component II, at which time the sealing plug 25 re-seals the second channel 22. The separate component I can be very conveniently connected to the pipette connector for drug solution transmission, or mounted to the bolus device for quantitative drug solution transmission.

[0097] The application of pipetting to the chemotherapy pump can be seen in Figure 4 , including:

[0098] First, the component I is fixedly connected to one end (provided with a rubber plug) of the pipette connector 9 by buckling, and the other end of the pipette connector 9 is fixedly connected to the infusion tube interface of the chemotherapy pump 10.

[0099] Second, the first syringe 1 is pushed forward, so that the front end of the first needle tube 31 and the second needle tube 32, including the front end channel port of the infusion channel and the exhaust channel, penetrates the first sealing member 82, and after piercing the rubber plug, it is in communication with the inner cavity of the pipette connector 9. The slide of the inner sleeve 83 is synchronously slid backward along the axial groove, and by rotating the first syringe 1 or the first sheath 81 to move to the transverse groove, the axial movement of the needle sealing assembly 8 is limited, achieving the effect of limiting and fixing.

[0100] Third, the first piston rod 12 is pushed, and the prepared drug solution in the first syringe 11 is pushed into the chemotherapy pump 10 through the infusion channel, and the capsule in the chemotherapy pump 10 will gradually expand to increase the pressure. During this process, the high-pressure drug solution will not leak from the exhaust channel because the exhaust channel is blocked by the sealing plug 25.

[0101] Example 3

[0102] Figure 5 Another form of the split type double-chamber gas pressure balanced drug solution transfer device of the present application is shown. Compared with the drug solution transfer device of example 2, the main difference is that a rotatable on-off valve 26 for controlling the penetration or blockage of the second channel 22 is arranged in the second channel 22 of the first needle seat 2, and a through hole is arranged in the valve. The through hole is aligned or misaligned with the second channel by rotating the on-off valve 26, which can conveniently realize the penetration or blockage of the two channels.

[0103] Figure 6 is a representative physical diagram of the drug solution transfer device. In the figure, Figure 6a is a sample physical diagram in the assembled state; Figure 6b is a sample physical diagram in the split state; Figure 6c is a sample physical diagram provided with various connectors.

[0104] Unlike existing double-chamber drug solution transfer devices, the drug solution transfer device of the present application can be conveniently adapted to existing bolus devices for quantitative drug solution transmission. For example, Figure 7As shown, the method using on the single-channel quantitative push injector includes steps of:

[0105] In the first step, after the drug solution is prepared (the drug solution is in the first syringe 11), the assembly I and the assembly II are separated, and the on-off valve 26 is rotated to misalign the inner through hole with the second channel 22. At this time, the sealing plug 25 reseals the second channel 22, and the on-off valve 26 blocks the second channel 22, which double-ensures the airtightness of the exhaust channel.

[0106] In the second step, the assembly I is fixedly connected with one end (provided with a rubber plug) of the pipette connector 9 by buckling, and the other end of the pipette connector 9 is fixedly connected to the infusion tube interface.

[0107] In the third step, the first syringe 1 is pushed forward, so that the front end of the first needle tube 31 and the second needle tube 32, including the front end channel port of the infusion channel and the exhaust channel, penetrates through the first sealing member 82, and after penetrating the rubber plug, is in communication with the inner cavity of the pipette connector 9. The sliding table of the inner sleeve 83 is synchronously slid along the axial groove, and is moved to the transverse groove by rotating the first syringe 1 or the first sheath 81, so as to limit the axial movement of the needle sealing assembly 8, and achieve the effect of limiting and fixing.

[0108] In the fourth step, the fixed hook on the quantitative push injector is pulled, so that the first syringe 11 is fixed on the quantitative push injector, and the end neck of the first piston rod 12 is installed on the fixed clamp, and the liquid pushing end abuts against the rear end surface of the first piston rod 12.

[0109] In the fifth step, the infusion program is set, the first piston rod 12 is pushed at a preset speed, so that the drug solution in the first syringe 11 is quantitatively delivered into the infusion tube.

[0110] In the above application, the connection between the assembly I and the quantitative push injector will not leak. The first syringe 11 can be stably installed on the quantitative push injector, and will not occupy the space of the quantitative push injector.

[0111] It is easy to understand that the drug solution transfer device of the present application is also applicable to the quantitative push injector with double channels or more channels.

[0112] Example 4

[0113] Figure 8Another form of the split two-chamber gas pressure balanced medicine liquid transfer device of the present application is shown. Compared with the medicine liquid transfer device of example 3, the main difference is that the dispensing needle assembly 3 is a double-layered columnar structure, which is composed of an inner needle tube and an outer needle tube integrally formed and fixedly connected with each other, the inner needle tube is arranged in the outer needle tube and extends out of the outer needle tube at both ends. At this time, the inner column channel formed by the inner cavity of the inner needle tube serves as the exhaust channel, and the side ring channel formed by the cavity between the outer needle tube and the inner needle tube serves as the infusion channel. The front end of the inner needle tube is a pointed end and is provided with a side opening, and the front end side wall of the outer needle tube is provided with a side opening.

[0114] The above examples mainly describe the basic principles, main features and advantages of the present application. Those skilled in the art should understand that the present application is not limited by the above examples, and the above examples and descriptions in the specification are only to illustrate the principles of the present application, and various changes and improvements can be made without departing from the spirit and scope of the present application, and these changes and improvements all fall within the scope of the claimed present application.

Claims

1. A split type double-chamber gas pressure balanced medicine liquid transfer device, comprising a component I and a component II, wherein: the component I comprises a first syringe, a first needle seat and a dispensing needle assembly, wherein the first needle seat is fixedly connected with the first syringe through a joint on the first syringe, and the dispensing needle assembly is fixedly connected on the first needle seat; an inner part of the first needle seat is provided with a first channel and a second channel, a side part is provided with a gas window, and an end part is provided with a cavity for fixed connection with the joint on the first syringe; an end part of the first channel is in communication with the cavity, and an end part of the second channel is in communication with the gas window; the gas window is provided with a sealing plug; the dispensing needle assembly comprises a liquid delivery channel and an exhaust channel, wherein the liquid delivery channel is in communication with the first channel, and the exhaust channel is in communication with the second channel; the component II comprises a second syringe, a second needle seat and a puncture needle fixedly connected on the second needle seat; when the component I and the component II are in a fixed connection state, the puncture needle of the component II penetrates the sealing plug in the gas window of the component I, and realizes communication with the second channel in the first needle seat; when the component I and the component II are separated, the sealing plug in the gas window makes the gas window in a sealed state.

2. The liquid medicine transfer device according to claim 1, characterized by: the first syringe comprises a first syringe barrel and a first piston rod which can slide in the first syringe barrel along an inner cavity; the second syringe comprises a second syringe barrel and a second piston rod which can slide in the second syringe barrel along an inner cavity.

3. The liquid medicine transfer device according to claim 2, characterized by: when the component I and the component II are in a fixed connection state, the first syringe barrel and the second syringe barrel are fixedly connected in a side-by-side and same direction manner.

4. The liquid medicine transfer device according to claim 3, characterized by: an outer wall of at least one of the first syringe barrel and the second syringe barrel is provided with a buckle structure, so that the first syringe barrel and the second syringe barrel are detachably fixed to each other when arranged in a side-by-side and same direction manner; and / or, at least one of the first syringe barrel and the second syringe barrel is provided with a support part on a barrel wall, an end part structure of the support part matches an outer side wall of the opposite syringe barrel, so that the first syringe barrel and the second syringe barrel are supported to each other through the support part when arranged in a side-by-side and same direction manner.

5. The liquid medicine transfer device according to claim 1, characterized by: the second channel in the first needle seat is provided with a pass-stop module for controlling the communication or isolation of the second channel.

6. The liquid medicine transfer device according to claim 5, characterized by: the pass-stop module is a rotatable pass-stop valve, an inner part of the pass-stop valve is provided with a through hole; the pass-stop valve is rotated to make the through hole in alignment or misalignment with the second channel, so as to realize the communication or isolation of the two channels; or, the pass-stop module is a control valve, the control valve comprises a sliding block and a sliding groove which is provided through the second channel from a radial direction, the sliding block is slidably arranged in the sliding groove, and the sliding block is provided with a through hole; when the sliding block is slid to a preset position, two ends of the through hole are respectively butted to the second channel; when the sliding block is slid out of the preset position, an outer side surface of the sliding block isolates the second channel.

7. The liquid medicine transfer device according to claim 1, characterized by: the first needle seat is provided with a protruding part on a side close to the second channel, and the gas window is arranged at an end part of the protruding part.

8. The liquid medicine transfer device according to claim 7, characterized by: the length of the protruding part exceeds the radius of the first syringe barrel.

9. The liquid medicine transfer device according to claim 1, characterized by: the dispensing needle assembly is composed of a first needle tube and a second needle tube which are arranged in parallel and embedded in a rear end part; an inner cavity of the first needle tube constitutes the liquid delivery channel, and a rear end port is in communication with the first channel; an inner cavity of the second needle tube constitutes the exhaust channel, and a rear end port is in communication with the second channel.

10. The liquid medicine transfer device according to claim 1, characterized by: The dispensing needle assembly is a double-layered cylindrical structure having an inner column channel and a side ring channel, one of which is a delivery channel and the other is an exhaust channel.

11. The liquid medicine transfer device according to claim 10, characterized by: The dispensing needle assembly is composed of an inner needle tube and an outer needle tube, the inner needle tube is arranged in the outer needle tube and extends out of the outer needle tube at both ends, at this time, the inner column channel is formed by the inner cavity of the inner needle tube, and the side ring channel is formed by the cavity between the outer needle tube and the inner needle tube.

12. The liquid medicine transfer device according to claim 1, characterized by: The assembly I further comprises a needle sealing assembly, the needle sealing assembly comprises a first sleeve, a first sealing member and a first elastic member arranged coaxially with the first needle seat; wherein, The first sleeve is a hollow cylindrical structure with front and rear openings, and is movably sleeved on the front end of the first needle seat; The first sealing member is made of elastic material and is fixedly arranged in the front end of the first sleeve; the first sealing member is provided with a hole for the needle tube to pass through, and the inner diameter of the hole is smaller than the outer diameter of the needle tube; The first elastic member is arranged between the first sealing member and the first needle seat, and relies on the needle seat, the first elastic member provides axial elastic support for the first sealing member at the front end; In the non-pressurized state, the first elastic member is axially stretched, the first sleeve shields the needle tube inside the sleeve, and under the action of the elastic force of the elastic material, the first sealing member tightly wraps the front end of the needle tube, and the front channel port of the delivery channel and the exhaust channel is closed inside; In the pressurized state, the first elastic member is axially compressed, and the front end of the needle tube including the front channel port of the delivery channel and the exhaust channel can pass out of the first sleeve through the hole of the first sealing member.

13. The liquid medicine transfer device according to claim 12, characterized by: The needle sealing assembly comprises a first sleeve, a first sealing member, a first elastic member and an inner sleeve arranged coaxially, wherein: The front end of the first sleeve has a smaller inner diameter, forming a composite cylindrical structure composed of a first cylinder segment with a smaller inner diameter and a second cylinder segment with a larger inner diameter; The first sealing member is designed as a structure with a reverse T-shaped cross section, the front diameter corresponds to the inner diameter of the first cylinder segment, and the rear diameter corresponds to the inner diameter of the second cylinder segment, so that the first sealing member can completely fill the inner cavity of the first cylinder segment while filling at least part of the inner cavity of the second cylinder segment; The inner diameter of the inner sleeve corresponds to the outer diameter of the first needle seat, and the outer diameter of the inner sleeve corresponds to the inner diameter of the second cylinder segment of the first sleeve, the front end face is closed and provided with a through hole for the needle tube to pass through; the inner sleeve is fixedly connected in the second cylinder segment of the first sleeve, and the front end face abuts against the rear end face of the first sealing member; The first elastic member is arranged in the inner sleeve, and the two ends abut against the front end inner surface of the inner sleeve and the front end face of the first needle seat respectively.

14. The medicine liquid transfer device according to claim 13, wherein: The outer wall of the inner sleeve is provided with a buckle, and the second cylinder segment of the first sleeve is provided with a corresponding buckle hole, and the fixed connection between the first sleeve and the inner sleeve is realized by the cooperation of the buckle and the buckle hole when the inner sleeve is inserted into the first sleeve.

15. The liquid medicine transfer device according to claim 14, characterized by: The rear end of the inner sleeve is provided with a ring-shaped boss in a radially outward manner, and when the front end face of the inner sleeve abuts against the rear end face of the first sealing member, the ring-shaped boss of the rear end is exposed to the first sleeve and abuts against the rear end of the first sleeve.

16. The liquid medicine transfer device according to claim 13, characterized by: The front end inner surface of the inner sleeve and the front end face of the first needle seat are both provided with a buckle structure, thereby realizing the fixed connection with the first elastic member.

17. The liquid medicine transfer device according to claim 13, characterized by: The side surface of the first needle seat is provided with an L-shaped groove composed of an axial groove and a transverse groove, and the rear end of the inner sleeve is radially provided with a sliding table which is embedded in the L-shaped groove and can slide along the groove.

18. The liquid medicine transfer device according to claim 12 or 13, characterized by: The front end surface of the first sealing member protrudes beyond the front end surface of the first sleeve.

19. The liquid medicine transfer device according to claim 12 or 13, characterized by: The front end of the first sleeve is provided with a fixed connection structure matched with the connector, so as to be fixedly connected with the connector.

20. The liquid medicine transfer device according to claim 7, characterized by: The second needle seat and the puncture needle in the assembly II are arranged perpendicularly to the second injection cylinder. When the first injection cylinder and the second injection cylinder are fixedly connected in a side-by-side and same-direction manner, the puncture needle transversely penetrates the sealing plug and realizes communication with the second channel in the first needle seat.

21. The liquid medicine transfer device according to claim 1, characterized by: The assembly II further comprises a puncture needle sealing assembly which comprises a second sleeve coaxially arranged with the puncture needle, a second sealing member and a second elastic member; wherein, The second sleeve is a hollow cylindrical structure with an open front end and is fixedly connected to the second needle seat at the rear end. The second sealing member is made of elastic material and is fixedly arranged in the front end cylinder of the second sleeve; the second sealing member is provided with a hole for the puncture needle to pass through, and the inner diameter of the hole is smaller than the outer diameter of the puncture needle. The second elastic member is arranged between the second sealing member and the second needle seat and relies on the needle seat to provide axial elastic support for the front end of the second sealing member. In a non-pressurized state, the second elastic member is axially stretched, the second sleeve hides the puncture needle inside the sleeve, and under the elastic force of the elastic material, the second sealing member tightly wraps the front end of the puncture needle and closes the puncture needle opening inside. In a pressurized state, the second sealing member slides to the rear end, the second elastic member is axially compressed, and the front end of the puncture needle penetrates out of the second sealing member.

22. The liquid medicine transfer device according to claim 21, characterized by: The puncture needle sealing assembly further comprises a sliding sleeve coaxially arranged with the puncture needle; the sliding sleeve is a hollow cylindrical structure with open front and rear ends and is arranged in the second sleeve, with an outer diameter matched with the inner diameter of the second sleeve and being axially slidable in the second sleeve, and the second sealing member is filled in the sliding sleeve.

23. The liquid medicine transfer device according to claim 22, characterized by: The sliding sleeve is designed as a composite cylindrical structure composed of a front cylinder segment with a larger inner diameter and a rear cylinder segment with a smaller inner diameter; correspondingly, the second sealing member is designed as a structure with a T-shaped cross section, so that the second sealing member can completely fill the inner cavity of the sliding sleeve.

24. The liquid medicine transfer device according to any one of claims 21 to 23, wherein: The first needle seat in the assembly I is radially provided with a protruding portion on one side close to the second channel, and the air window is arranged at the end of the protruding portion; the second needle seat, the puncture needle and the puncture needle sealing assembly in the assembly II are arranged perpendicularly to the second injection cylinder; when the first injection cylinder and the second injection cylinder are fixedly connected in a side-by-side and same-direction manner, the air window provided with the sealing plug is inserted into the second sleeve and pushes the second sealing member or the sliding sleeve filled with the second sealing member to slide to the rear end, the second elastic member is axially compressed, the front end of the puncture needle penetrates out of the second sealing member and penetrates the sealing plug, and realizes communication with the second channel in the first needle seat.

25. The liquid medicine transfer device according to any one of claims 21 to 23, wherein: The front end of the second sleeve is provided with a fixed buckle structure, and the protruding portion of the first needle seat is provided with a fixed buckle groove matched with the fixed buckle structure; when the assembly I and the assembly II are fixedly connected, the fixed buckle structure and the fixed buckle groove are fixed to each other.

26. The use of the medicine liquid transfer device according to any one of claims 1-25 in a quantitative infusion.

27. A device for the controlled administration of a liquid, comprising: A drug solution transfer device comprising the drug solution transfer device according to any one of claims 1 to 25.

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