A supramolecular hydrogel based on natural plant ingredients, its preparation and use

Hydrogels prepared by supramolecular interactions between polyphenols and natural polysaccharides solve the problems of complex preparation and high cost in existing technologies, achieving rapid and low-cost wound healing effects, and possessing antibacterial, antioxidant and cell proliferation-promoting functions.

CN117084970BActive Publication Date: 2026-05-05HUAZHONG UNIV OF SCI & TECH
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Patent Information

Application Number
CN202311106397.8
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-08-30
Publication Date
2026-05-05
Estimated Expiration
2043-08-30

AI Technical Summary

Technical Problem

Existing injectable hydrogel wound dressings require complex processes such as ultraviolet light irradiation, heating, and the addition of chemical cross-linking agents during preparation, which increases costs and time, disrupts the balance of the wound healing environment, and makes it difficult to directly construct therapeutic molecules.

Method used

Supramolecular hydrogels are prepared by using non-covalent supramolecular interactions between polyphenols and natural polysaccharides through simple mixing. The preparation process is simple and does not require heating, modification or introduction of chemical cross-linking agents, and is suitable for in-situ injection with syringes.

Benefits of technology

It achieves low-cost, rapid gelation, high biocompatibility, and can effectively adhere to the skin. It is antibacterial, antioxidant, and anti-inflammatory, promotes angiogenesis and cell proliferation, and promotes wound healing. It is suitable for healing large-area skin trauma, burns, and chronic ulcers.

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Abstract

The application belongs to the field of hydrogel biological medicine, and more particularly discloses a kind of supramolecular hydrogel based on natural plant ingredients, preparation and application thereof.The hydrogel only contains polyphenol, polysaccharide and solvent, and the hydrogel is in-situ gelled only by supramolecular interaction between polyphenol and polysaccharide.The hydrogel of the application can be prepared by simple mixing, and can also be in-situ injected by a syringe.The hydrogel preparation process is simple, the raw material cost is low, and the gelation speed is fast;the hydrogel can effectively adhere to the skin, isolate the contact between the wound and the external environment, avoid the invasion of pathogens, at the same time, it is breathable and moisturizing, can provide a suitable moist environment for wound healing, and can completely and quickly release polyphenol.The hydrogel also has excellent antibacterial, antioxidant, anti-inflammatory and pro-angiogenic functions, so it can accelerate wound healing and accelerate bacterial infection wound healing.
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