A device, system and method for detecting weak electromagnetic signals of a sample

Abstract

The present application provides a device, system and method for detecting weak electromagnetic signals of a sample, comprising a driving module, N Helmholtz coils, a low-temperature container, two SQUID modules, a first signal processing module and a second signal processing module; N is a natural number greater than 1; the driving module provides driving signals for each Helmholtz coil, each SQUID module includes a SQUID galvanometer and a gradiometer; the input end of each SQUID galvanometer is connected to each gradiometer; the input end of the first signal processing module is connected to the output end of each SQUID galvanometer, and outputs a first processing signal to the second signal processing module; the second signal processing module determines whether the processing signal produces random resonance. The present application can realize synchronous detection, that is, the sample of the substance to be tested dissolved in the solvent and the sample containing pure solvent are tested synchronously at the same time, further avoiding the error caused by the time difference caused by separate testing.

Description

Technical Field

[0001] This invention belongs to the field of electromagnetic signal detection technology, and relates to a device, system and method for detecting weak electromagnetic signals of a sample. Background Technology

[0002] Because the movement of atoms and electrons within molecules generates weak molecular electromagnetic signals, these signals carry information about the molecule's structure and properties. Therefore, detecting these weak molecular electromagnetic signals is of great significance for fields such as material analysis, chemical reaction monitoring, and biomedical diagnostics.

[0003] In existing technologies, the principle of random resonance is used to improve the detection accuracy of molecular electromagnetic signals, typically employing a single-channel superconducting quantum interference device (SQUID) for signal acquisition. However, when the analyte is dissolved in a solvent for detection, it is difficult to distinguish between the detected molecular electromagnetic signals originating from the solvent and those from the analyte.

[0004] Therefore, based on the above problems, it is necessary to further optimize the SQUID system and detection method to study whether the detected substance is a molecular electromagnetic signal of the solvent or a molecular electromagnetic signal of the solute when the substance to be detected is dissolved in a solvent.

[0005] It should be noted that the above description of the technical background is only for the purpose of providing a clear and complete explanation of the technical solutions of the present invention and facilitating understanding by those skilled in the art. It should not be assumed that the above technical solutions are known to those skilled in the art simply because they have been described in the background section of this invention. Summary of the Invention

[0006] In view of the shortcomings of the prior art described above, the purpose of this invention is to provide a device, system and method for detecting weak electromagnetic signals of samples, to solve the problem in the prior art that when the substance to be detected is dissolved in a solvent and the signal is acquired and detected by a single-channel SQUID system, it is difficult to distinguish whether the detected molecular electromagnetic signal is from the solvent or the substance to be detected.

[0007] To achieve the above and other related objectives, the present invention provides a device for detecting weak electromagnetic signals of a sample, the device comprising: a driving module, N Helmholtz coils, a cryogenic container, two SQUID modules, a first signal processing module and a second signal processing module; N is a natural number greater than 1;

[0008] The drive module provides drive signals to each Helmholtz coil, and each Helmholtz coil is uniformly surrounded around the periphery of the cryogenic container;

[0009] Both SQUID modules are housed within the cryogenic container, which provides a non-magnetic cryogenic environment for the two SQUID modules.

[0010] Each SQUID module includes a SQUID galvanometer and a gradient meter; the input terminal of each SQUID galvanometer is connected to the corresponding gradient meter to detect the molecular electromagnetic signal of the corresponding sample.

[0011] The input terminal of the first signal processing module is connected to the output terminal of each SQUID galvanometer to read the electromagnetic signal of each molecule, perform subtraction, and output the processed signal to the second signal processing module.

[0012] The second signal processing module determines whether the processed signal generates random resonance; and stores the processed signal that generates random resonance; the output terminal of the second signal processing module is connected to the input terminal of the driving module to adjust the intensity of the driving module when no random resonance is generated.

[0013] Optionally, the drive module includes an adder for adding white noise and a DC source to drive each Helmholtz coil.

[0014] Optionally, the thickness of the bottom of the cryogenic container ranges from 1 mm to 20 mm, and / or the diameter of each gradient meter ranges from 2 mm to 40 mm.

[0015] Optionally, the device for detecting weak electromagnetic signals of a sample further includes a support component for fixing each Helmholtz coil.

[0016] Optionally, the first signal processing module includes two flux-locking units and a subtraction unit; the input terminal of each flux-locking unit is connected to the output terminal of each SQUID galvanometer to read the molecular electromagnetic signal of each sample; the input terminal of the subtraction unit is connected to the output terminal of each flux-locking unit to subtract the molecular electromagnetic signals and output the processed signal.

[0017] Optionally, the first signal processing module further includes a calibration module, which is connected between the output of one of the flux-locked units and the input of the subtraction unit to adjust the phase and / or amplitude of the signal output by the corresponding SQUID module when there is no sample, so that the phase and amplitude of the signal output by each SQUID module are consistent.

[0018] Optionally, the device for detecting weak electromagnetic signals of the sample further includes a shielding unit, which includes a magnetic shielding barrel and a radio frequency shielding container. The cryogenic container, two SQUID modules, and each Helmholtz coil are all disposed inside the magnetic shielding barrel to shield against external static magnetic fields. The magnetic shielding barrel and the first signal processing module are disposed inside the radio frequency shielding container to shield against external high-frequency electromagnetic fields.

[0019] The present invention also provides a system for detecting weak electromagnetic signals of a sample, comprising at least: a first sample containing a pure solvent, a second sample containing a substance to be tested and a solvent, a sample holder, and a device for detecting weak electromagnetic signals of the sample as described above; the solvent content in the first sample and the solvent content in the second sample are the same;

[0020] The first sample and the second sample are placed in the sample holder, which is located at the bottom of the low-temperature container, and the first sample and the second sample are in contact with the bottom of the low-temperature container; the first sample and the second sample are respectively located below each SQUID module.

[0021] The present invention also provides a method for detecting weak electromagnetic signals of a sample, based on the above-described system implementation for detecting weak electromagnetic signals of a sample, wherein the method for detecting weak electromagnetic signals of a sample includes at least:

[0022] A) The driving module provides driving signals to each Helmholtz coil, and each Helmholtz coil applies a magnetic field to the first sample and the second sample;

[0023] B) The two SQUID modules respectively detect the electromagnetic signal of the first molecule of the first sample and the electromagnetic signal of the second molecule of the second sample;

[0024] C) The first signal processing module reads out the first molecular electromagnetic signal and the second molecular electromagnetic signal and subtracts them to obtain the third molecular electromagnetic signal of the substance to be tested;

[0025] D) The second signal processing module determines whether the third molecular electromagnetic signal generates random resonance; if random resonance occurs, the third molecular electromagnetic signal is stored; if random resonance does not occur, the intensity of the driving module is adjusted, and the process returns to step A).

[0026] Optionally, before step A), a phase amplitude adjustment and calibration step is required for each SQUID module before the first signal processing module reads out and subtracts the molecular electromagnetic signals output by each SQUID module.

[0027] As described above, the present invention provides a device, system, and method for detecting weak electromagnetic signals in a sample, which has the following beneficial effects:

[0028] 1. This invention enables synchronous detection, meaning that the sample containing the analyte dissolved in the solvent and the sample containing the pure solvent are tested synchronously under the same testing environment and at the same time, further avoiding errors caused by time differences due to separate testing. It can detect the molecular electromagnetic signal of the analyte after the solvent has been removed in real time and effectively.

[0029] 2. This invention simplifies the data processing process and improves the detection accuracy by setting up a first signal processing module and a second signal processing module to process the molecular electromagnetic signals detected by the SQUID module.

[0030] 3. The driving mechanism of this invention adds a DC source to the white noise, which can further ensure that the output molecular electromagnetic signal generates random resonance during the detection process.

[0031] 4. The detection system of the present invention has high consistency, which further improves the reliability of the detection structure. Attached Figure Description

[0032] Figure 1 The diagram shown is a structural schematic of the weak electromagnetic signal detection device for the sample of this invention.

[0033] Figure 2 The diagram shown is a structural block diagram of the driving module of the present invention.

[0034] Figure 3 The diagram shown is a structural block diagram of the first signal processing module of the present invention.

[0035] Figure 4 The diagram shown is a structural block diagram of the second signal processing module of the present invention.

[0036] Figure 5 The diagram shown is a structural schematic of the weak electromagnetic signal system for detecting samples according to the present invention.

[0037] Figure 6 The flowchart shown is a method for detecting weak electromagnetic signals of a sample according to the present invention.

[0038] Component designation explanation

[0039] 1. Device for detecting weak electromagnetic signals in samples

[0040] 10. Driver Module

[0041] 100 adders

[0042] 11 Helmholtz coils

[0043] 110 connecting cable

[0044] 12 cryogenic containers

[0045] 120 Liquid Helium

[0046] 130 First SQUID Module

[0047] 130a First SQUID galvanometer

[0048] 130b First Gradient Meter

[0049] 131 Second SQUID Module

[0050] 131a Second SQUID galvanometer

[0051] 131b Second Gradient Meter

[0052] 14 First Signal Processing Module

[0053] 140 Flux Locking Unit

[0054] 140a First Flux Locking Unit

[0055] 140b Second Flux Locking Unit

[0056] 141 Subtraction Unit

[0057] 142 Calibration Module

[0058] 15 Second Signal Processing Module

[0059] 150 Data Acquisition Card

[0060] 151 Host Computer

[0061] 16 Support components

[0062] 17 Shielding Units

[0063] 170 Magnetic Shielding Barrel

[0064] 171 Radio Frequency Shielding Container

[0065] 2. A system for detecting weak electromagnetic signals in samples.

[0066] 20 First Sample

[0067] 21 Second Sample

[0068] 22 Sample trays Detailed Implementation

[0069] The following specific examples illustrate the implementation of the present invention. Those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification.

[0070] Please see Figures 1 to 6 It should be understood that the structures, proportions, sizes, etc., illustrated in the accompanying drawings are merely for illustrative purposes to aid those skilled in the art and to facilitate understanding and reading. They are not intended to limit the scope of the invention and therefore have no substantial technical significance. Any alterations to the structure, proportions, or sizes, provided they do not affect the effectiveness or purpose of the invention, should still fall within the scope of the technical content disclosed herein. Furthermore, the terms "upper," "lower," "left," "right," "middle," and "one" used in this specification are merely for clarity and not intended to limit the scope of the invention. Changes or adjustments to their relative relationships, without substantially altering the technical content, should also be considered within the scope of the invention.

[0071] like Figure 1 As shown, this embodiment provides a device 1 for detecting weak electromagnetic signals of a sample, including: a driving module 10, N Helmholtz coils 11, a cryogenic container 12, two SQUID modules, a first signal processing module 14, and a second signal processing module 15; N is a natural number greater than 1.

[0072] like Figure 1 As shown, the drive module 10 provides drive signals to each Helmholtz coil 11.

[0073] Specifically, in this embodiment, such as Figure 2 As shown, the drive module 10 includes an adder 100 for adding white noise and a DC source and outputting the sum to each Helmholtz coil 11. Each Helmholtz coil 11 is driven by white noise and a DC source to apply a white noise magnetic field and a static magnetic field bias to the sample, further ensuring random resonance during the detection process.

[0074] like Figure 1 As shown, each Helmholtz coil 11 is uniformly surrounded around the cryogenic container 12 to ensure that the magnetic field strength is the same at all samples. Meanwhile, the device 1 for detecting the weak electromagnetic signals of the samples also includes a support component 16.

[0075] Specifically, in this embodiment, there are two Helmholtz coils 11, which are positioned opposite each other at both ends of the cryogenic container 12. In actual use, the number of Helmholtz coils can be arbitrarily set according to the detection needs and is not limited to this embodiment. Each Helmholtz coil 11 is fixed to the support component 16. As an example one, the Helmholtz coils 11 are connected to each other by connecting wires 110, and the drive module 10 is connected to one of the Helmholtz coils to transmit the drive signal to each Helmholtz coil 11. As an example two, the drive module 10 is connected to each Helmholtz coil to transmit the drive signal to each Helmholtz coil. In actual use, any drive module capable of transmitting the drive signal to each Helmholtz coil and the connection relationship between each Helmholtz coil can be arbitrarily set as needed, and will not be elaborated here.

[0076] like Figure 1 As shown, both SQUID modules are housed within the cryogenic container 12, which provides a non-magnetic cryogenic environment for the two SQUID modules.

[0077] Specifically, in this embodiment, the cryogenic container 12 includes, but is not limited to, a non-magnetic liquid helium Dewar. Two SQUID modules are placed in the cryogenic container 12 and completely immersed in liquid helium 120, so that the SQUID modules are in a non-magnetic cryogenic environment during the detection process. In practical use, any cryogenic container that can provide a non-magnetic cryogenic environment for the SQUID modules is suitable for this invention, and will not be described in detail here. The bottom thickness of the cryogenic container 12 ranges from 1mm to 20mm, including but not limited to 1.5mm, 3mm, 6mm, 9mm, and 18mm. In practical use, the bottom thickness of the cryogenic container can be arbitrarily set as needed and is not limited to this embodiment.

[0078] like Figure 1 As shown, each SQUID module includes a SQUID galvanometer and a gradient meter; the input terminal of each SQUID galvanometer is connected to the corresponding gradient meter to detect the molecular electromagnetic signal of the corresponding sample.

[0079] Specifically, in this embodiment, the two SQUID modules are a first SQUID module 130 and a second SQUID module 131. The first SQUID module 130 includes a first SQUID galvanometer 130a and a first gradient meter 130b, and the second SQUID module 131 includes a second SQUID galvanometer 131a and a second gradient meter 131b. The first gradient meter 130b and the second gradient meter 131b include, but are not limited to, second-order gradient meters to improve detection sensitivity. In practical use, the order of the first and second gradient meters can be arbitrarily set as needed, and will not be elaborated here. The diameter range of each gradient meter is 2mm to 40mm (the diameter of the first gradient meter 130b is equal to the diameter of the second gradient meter 131b), including but not limited to 3mm, 6mm, 12mm, 18mm, and 32mm. In practical use, the diameter of each gradient meter can be arbitrarily set as needed, and will not be elaborated here. Furthermore, the distance between the center of the first gradient meter 130b and the center of the second gradient meter 131b is greater than twice the diameter of the first gradient meter to prevent signal crosstalk between the first gradient meter 130b and the second gradient meter 131b due to excessive proximity, thus avoiding the introduction of additional errors. By placing the first gradient meter 130b and the second gradient meter 131b close to the bottom of the cryogenic container 12, and setting the bottom thickness range of the cryogenic container 12 and the diameter range of each gradient meter, the distance between each gradient meter and the corresponding sample is reduced, thereby achieving a stronger signal on the sample during the detection process and increasing the signal-to-noise ratio.

[0080] like Figure 1 As shown, the input terminal of the first signal processing module 14 is connected to the output terminal of each SQUID galvanometer to read the electromagnetic signal of each molecule, perform subtraction processing, and output the processed signal to the second signal processing module 15.

[0081] Specifically, in this embodiment, such as Figure 3As shown, the first signal processing module 14 includes two flux-locked units 140 and a subtraction unit 141. The input terminal of each flux-locked unit 140 is connected to the output terminal of each SQUID galvanometer. The two flux-locked units are respectively configured as a first flux-locked unit 140a and a second flux-locked unit 140b, that is, the input terminal of the first flux-locked unit 140a is connected to the output terminal of the first SQUID galvanometer 130a, and the input terminal of the second flux-locked unit 140b is connected to the output terminal of the second SQUID galvanometer 131b; to read the molecular electromagnetic signals of each sample. In actual use, the number of flux-locked units is set according to the number of SQUID modules, which will not be elaborated here. The input terminal of the subtraction unit 141 is connected to the output terminal of each flux-locked unit 140 to subtract the obtained molecular electromagnetic signals and output the processed signal. The subtraction unit 141 includes, but is not limited to, a differential amplifier to subtract and amplify the obtained molecular electromagnetic signals in real time. In practical use, any structure that can read out and subtract signals is applicable to the first signal processing module of the present invention, and will not be described in detail here.

[0082] More specifically, in this embodiment, as Figure 3 As shown, the first signal module 14 also includes a calibration module 18, which is connected between the output of one of the flux-locking units and the input of the subtraction unit 141 (for example, the calibration module 18 is connected between the output of the second flux-locking unit 140a and the input of the subtraction unit 141). This calibration module adjusts the phase and / or amplitude of the signals output by the corresponding SQUID modules when no sample is available, ensuring that the phase and amplitude of the signals output by each SQUID module are consistent (i.e., in the absence of a sample, by adjusting the phase and amplitude of the signal output by the second SQUID module, the phase and amplitude of the signals output by the first SQUID module 130 and the second SQUID module 131 are consistent). In practical use, any structure capable of adjusting the phase and amplitude of the signals output by the SQUID modules is suitable for the calibration module of this invention, and will not be described in detail here.

[0083] like Figure 1 As shown, the second signal processing module 15 determines whether the processed signal generates random resonance; and stores the processed signal that generates random resonance; the output terminal of the second signal processing module 15 is connected to the input terminal of the drive module 10 to adjust the intensity of the drive module 10 when no random resonance is generated.

[0084] Specifically, in this embodiment, such as Figure 4As shown, the second signal processing module 15 includes a data acquisition card 150 and a host computer 151. The data acquisition card 150 performs digitization processing on the processed signal and outputs it to the host computer 151. The host computer 151 determines whether the processed signal after digitization produces random resonance. If random resonance occurs, the processed signal that produced random resonance is stored. The output terminal of the host computer 151 is connected to the input terminal of the drive module 10 to adjust the intensity of the drive module 10 when no random resonance occurs. In practical use, any device capable of digitizing, judging, storing, and adjusting the intensity of the drive module for the processed signal is applicable to the second signal processing module of this invention, and will not be described in detail here.

[0085] like Figure 1 As shown, the device 1 for detecting weak electromagnetic signals of a sample also includes a shielding unit 17. The shielding unit 17 includes a magnetic shielding barrel 170 and a radio frequency shielding container 171. The cryogenic container 12, two SQUID modules and each Helmholtz coil 11 are all disposed inside the magnetic shielding barrel 170 to shield external static magnetic fields. The magnetic shielding barrel 170 and the first signal processing module 14 are disposed inside the radio frequency shielding container 171 to shield external high-frequency electromagnetic fields.

[0086] Specifically, in this embodiment, the magnetic shielding barrel 170 is made of permalloy (an iron-nickel alloy). Permalloy has high magnetic permeability. By setting up a cryogenic container 12, two SQUID modules, and Helmholtz coils 11 inside the magnetic shielding barrel 170, external static magnetic fields are shielded during the detection process, reducing errors. In practical use, any material of the magnetic shielding barrel capable of shielding external static magnetic fields is suitable for this invention, and will not be described in detail here. The radio frequency shielding container 171 is made of aluminum plate. By setting up the magnetic shielding barrel 170 and the first signal processing module 14 inside the radio frequency shielding container 171, external high-frequency electromagnetic interference is shielded during the detection process, further reducing errors. In practical use, any material of the radio frequency shielding container capable of shielding external high-frequency electromagnetic interference is suitable for this invention, and will not be described in detail here.

[0087] like Figure 5 As shown, the present invention also provides a system 2 for detecting weak electromagnetic signals of a sample, comprising: a first sample 20 containing pure solvent, a second sample 21 containing the analyte and solvent, a sample holder 22, and a device 1 for detecting weak electromagnetic signals of the sample; the solvent content in the first sample 20 is the same as that in the second sample 21, so as to reduce detection errors and improve the reliability of detection results.

[0088] like Figure 5As shown, the first sample 20 and the second sample 21 are placed in the sample holder 22, which is located at the bottom of the low-temperature container 12, and the first sample 20 and the second sample 21 are in contact with the bottom of the low-temperature container 12; the first sample 20 and the second sample 21 are respectively located below each SQUID module.

[0089] Specifically, in this embodiment, the first sample 20 is positioned directly below the first gradient meter 130b, and the second sample 21 is positioned directly below the second gradient meter 131b. The distance from the first sample 20 to the first gradient meter 130b is equal to the distance from the second sample 21 to the second gradient meter 131b, which improves the signal-to-noise ratio and reduces errors during the detection process.

[0090] like Figure 6 As shown, the present invention also provides a method for implementing a weak electromagnetic signal system 2 based on a detection sample, comprising:

[0091] A) The driving module 10 provides driving signals to each Helmholtz coil 11, and each Helmholtz coil 11 applies a magnetic field to the first sample 20 and the second sample 21.

[0092] Specifically, in this embodiment, before the sample is detected (i.e., before step A), a phase and amplitude adjustment calibration step is required for each SQUID module (before the first signal processing module reads out and subtracts the molecular electromagnetic signals output by each SQUID module). That is, in the absence of a sample, the calibration module 18 adjusts the phase and / or amplitude of the signal output by the second SQUID module 131 so that the phase and amplitude of the signals output by the first SQUID module 130 and the second SQUID module 131 are consistent, and by fast Fourier transform, it is observed that there are no interference peaks in the spectrum, that is, the calibration is complete.

[0093] More specifically, in this embodiment, the white noise and the DC source are added together by the adder 100 in the drive module 10 and output to each Helmholtz coil 11 to apply a white noise magnetic field and a static magnetic field bias of arbitrary intensity to the first sample 20 and the second sample 21 (the intensity of the white noise magnetic field and static magnetic field bias of the first sample 20 is equal to the intensity of the white noise magnetic field and static magnetic field bias of the second sample 21), further ensuring that random resonance can be generated. In actual use, the intensity of the white noise magnetic field and the static magnetic field bias can be arbitrarily set as needed, which will not be elaborated here.

[0094] B) The two SQUID modules respectively detect the electromagnetic signal of the first molecule of the first sample 20 and the electromagnetic signal of the second molecule of the second sample 21;

[0095] Specifically, in this embodiment, the first SQUID module 130 detects the first molecular electromagnetic signal of the first sample 20, the second SQUID module 131 detects the second molecular electromagnetic signal of the second sample 21, and the input terminal of the first signal processing module 14 is connected to the output terminal of each SQUID module to receive the first molecular electromagnetic signal and the second molecular electromagnetic signal.

[0096] C) The first signal processing module 14 reads out the electromagnetic signal of the first molecule and the electromagnetic signal of the second molecule and subtracts them to obtain the electromagnetic signal of the third molecule of the substance to be tested.

[0097] Specifically, in this embodiment, the first flux-locking unit 140a in the first signal processing module 14 reads the first molecular electromagnetic signal to the subtraction unit 141, and the second flux-locking unit 140b reads the second molecular electromagnetic signal and outputs it to the subtraction unit 141. The subtraction unit 141 subtracts the first and second molecular electromagnetic signals to obtain the third molecular electromagnetic signal of the substance to be tested, and outputs the third molecular electromagnetic signal to the second signal processing module 15.

[0098] D) The second signal processing module 15 determines whether the third molecular electromagnetic signal generates random resonance; if random resonance occurs, the third molecular electromagnetic signal is stored; if random resonance does not occur, the intensity of the driving module is adjusted, and the process returns to step A).

[0099] Specifically, in this embodiment, the electromagnetic signal of the third molecule is digitized by the data acquisition card in the second signal processing module 15, including but not limited to Fourier transform and cross-correlation analysis, to further obtain the characteristic frequency and other information of the analyte. In practical use, any device capable of digitizing molecular electromagnetic signals is suitable for the second signal processing module of this invention, and will not be described in detail here. The processed signal after digitization by the data acquisition card is output to the host computer, which determines whether the electromagnetic signal of the third molecule generates random resonance. If no random resonance occurs, i.e., the characteristic signal peak of the sample is not detected, the host computer 16 needs to adjust the intensity of the white noise magnetic field and the static magnetic field bias, and then return to step A) to continue the detection until random resonance occurs (i.e., the characteristic signal peak of the sample is detected) and stored.

[0100] In summary, this invention provides a device, system, and method for detecting weak electromagnetic signals of a sample. The device for detecting weak electromagnetic signals of a material includes: a driving module, N Helmholtz coils, a cryogenic container, two SQUID modules, a first signal processing module, and a second signal processing module; N is a natural number greater than 2; the driving module provides driving signals to each Helmholtz coil, and each Helmholtz coil is uniformly surrounded around the cryogenic container; both SQUID modules are disposed inside the cryogenic container, which provides a non-magnetic cryogenic environment for the two SQUID modules; each SQUID module is enclosed in... The invention includes a SQUID galvanometer and a gradient meter. The input of each SQUID galvanometer is connected to its corresponding gradient meter to detect the molecular electromagnetic signal of the corresponding sample. The input of a first signal processing module is connected to the output of each SQUID galvanometer to read the molecular electromagnetic signal, perform subtraction, and output the processed signal to a second signal processing module. The second signal processing module determines whether the processed signal generates random resonance and stores the processed signal that generates random resonance. The output of the second signal processing module is connected to the input of a drive module to adjust the intensity of the drive module when no random resonance occurs. This invention enables synchronous detection, meaning that samples of the analyte dissolved in a solvent and samples containing pure solvent are tested synchronously under the same testing environment and at the same time. This further avoids errors caused by time differences due to separate testing. It can detect the molecular electromagnetic signal of the analyte after removing the solvent in real time and effectively, simplifying the data processing process and improving the accuracy of detection. Simultaneously, the detection system of this invention has high consistency, further improving the reliability of the detection structure. Therefore, this invention effectively overcomes the various shortcomings of the prior art and has high industrial application value.

[0101] The above embodiments are merely illustrative of the principles and effects of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or alter the above embodiments without departing from the spirit and scope of the present invention. Therefore, all equivalent modifications or alterations made by those skilled in the art without departing from the spirit and technical concept disclosed in the present invention should still be covered by the claims of the present invention.

Claims

1. A device for detecting weak electromagnetic signals in a sample, characterized in that, The device for detecting weak electromagnetic signals of materials includes: a driving module, N Helmholtz coils, a cryogenic container, two SQUID modules, a first signal processing module, and a second signal processing module; N is a natural number greater than 1. The drive module provides drive signals to each Helmholtz coil, and each Helmholtz coil is uniformly surrounded around the periphery of the cryogenic container; Both SQUID modules are housed within the cryogenic container, which provides a non-magnetic cryogenic environment for the two SQUID modules. Each SQUID module includes a SQUID galvanometer and a gradient meter; the input terminal of each SQUID galvanometer is connected to the corresponding gradient meter to detect the molecular electromagnetic signal of the corresponding sample. The input terminal of the first signal processing module is connected to the output terminal of each SQUID galvanometer to read the electromagnetic signal of each molecule, perform subtraction, and output the processed signal to the second signal processing module. The second signal processing module determines whether the processed signal generates random resonance; and stores the processed signal that generates random resonance; the output terminal of the second signal processing module is connected to the input terminal of the driving module to adjust the intensity of the driving module when no random resonance is generated.

2. The apparatus for detecting weak electromagnetic signals of a sample according to claim 1, characterized in that: The drive module includes an adder for adding white noise and a DC source to drive each Helmholtz coil.

3. The apparatus for detecting weak electromagnetic signals of a sample according to claim 1, characterized in that: The thickness of the bottom of the cryogenic container ranges from 1 mm to 20 mm, and / or the diameter of each gradient meter ranges from 2 mm to 40 mm.

4. The apparatus for detecting weak electromagnetic signals of a sample according to claim 1, characterized in that: The device for detecting weak electromagnetic signals of a sample also includes a support component for fixing each Helmholtz coil.

5. The apparatus for detecting weak electromagnetic signals of a sample according to claim 1, characterized in that: The first signal processing module includes two flux-locked units and a subtraction unit; the input terminal of each flux-locked unit is connected to the output terminal of each SQUID galvanometer to read the molecular electromagnetic signal of each sample; the input terminal of the subtraction unit is connected to the output terminal of each flux-locked unit to subtract the molecular electromagnetic signals and output the processed signal.

6. The apparatus for detecting weak electromagnetic signals of a sample according to claim 5, characterized in that: The first signal processing module further includes a calibration module, which is connected between the output of one of the flux-locked units and the input of the subtraction unit to adjust the phase and / or amplitude of the signal output by the corresponding SQUID module when there is no sample, so that the phase and amplitude of the signal output by each SQUID module are consistent.

7. The apparatus for detecting weak electromagnetic signals of a sample according to claim 1, characterized in that: The device for detecting weak electromagnetic signals of the sample also includes a shielding unit, which includes a magnetic shielding barrel and a radio frequency shielding container. The cryogenic container, two SQUID modules, and each Helmholtz coil are all disposed inside the magnetic shielding barrel to shield against external static magnetic fields. The magnetic shielding barrel and the first signal processing module are disposed inside the radio frequency shielding container to shield against external high-frequency electromagnetic fields.

8. A system for detecting weak electromagnetic signals in a sample, characterized in that, The system for detecting weak electromagnetic signals of a sample comprises: a first sample containing a pure solvent, a second sample containing the analyte and a solvent, a sample holder, and a device for detecting weak electromagnetic signals of a sample as described in any one of claims 1-7; the solvent content in the first sample is the same as the solvent content in the second sample; The first sample and the second sample are placed in the sample holder, which is located at the bottom of the low-temperature container, and the first sample and the second sample are in contact with the bottom of the low-temperature container; the first sample and the second sample are respectively located below each SQUID module.

9. A method for detecting weak electromagnetic signals of a sample, implemented based on the weak electromagnetic signal detection system for a sample as described in claim 8, characterized in that, The method for detecting weak electromagnetic signals in a sample includes: A) The driving module provides driving signals to each Helmholtz coil, and each Helmholtz coil applies a magnetic field to the first sample and the second sample; B) The two SQUID modules respectively detect the electromagnetic signal of the first molecule of the first sample and the electromagnetic signal of the second molecule of the second sample; C) The first signal processing module reads out the first molecular electromagnetic signal and the second molecular electromagnetic signal and subtracts them to obtain the third molecular electromagnetic signal of the substance to be tested; D) The second signal processing module determines whether the third molecular electromagnetic signal generates random resonance; if random resonance occurs, the third molecular electromagnetic signal is stored; if random resonance does not occur, the intensity of the driving module is adjusted, and the process returns to step A).

10. The method for detecting weak electromagnetic signals in a sample according to claim 9, characterized in that: The method for detecting weak electromagnetic signals of a sample includes, before step A), a phase amplitude adjustment and calibration step for each SQUID module before the first signal processing module reads out and subtracts the molecular electromagnetic signals output by each SQUID module.

Images