Traditional Chinese medicine composition with anti-uric acid effect and preparation method and application of extracting solution of traditional Chinese medicine composition

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition with an anti-uric acid effect and a preparation method and application of an extracting solution of the traditional Chinese medicine composition. The traditional Chinese medicine composition with the uric acid resisting effect comprises the following raw materials in parts by weight: 3-5 parts of chicory, 1.5-2.5 parts of platycodon grandiflorum and 1 part of phellinus igniarius. The traditional Chinese medicine composition adopts medicinal and edible traditional Chinese medicines, and is safe and effective. Through compounding and synergy of the chicory, the platycodon grandiflorum and the phellinus igniarius, the traditional Chinese medicine composition has the effects of resisting oxidation, resisting inflammation, improving immunity and the like, can improve symptoms, and can repair the overall function of an organism from the source to completely eradicate and prevent generation of phlegm dampness and turbid stasis, so that generation of uric acid is inhibited and reduced.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition with anti-uric acid effect and a preparation method and application of its extract. Background Art

[0002] Uric acid is the final product of purine metabolism in the human body and is mainly excreted from the body through the kidneys. Uric acid is mainly detected through blood tests and is a renal function item in the biochemical examination. High or low uric acid levels may indicate some health problems, such as simple hyperuricemia, gout, nephritis, liver necrosis and hepatolenticular degeneration.

[0003] At present, Western medicine mainly treats hyperuricemia by using drugs such as Febuxostat, Allopurinol, and Benzbromarone to inhibit the production of uric acid or promote the excretion of uric acid, as well as treating the primary disease. However, the efficacy of drugs for the clinical treatment of hyperuricemia and gout is limited, and they can induce various adverse reactions, such as allergic reactions, cardiovascular events, fulminant hepatitis, etc., causing varying degrees of damage to the body. Therefore, there is an urgent need to find more effective and safer foods or drugs to reduce the risk of hyperuricemia and gout.

[0004] The patent document with publication number CN105749072A discloses a Chinese medicine composition for preventing and treating hyperuric acid and hyperlipidemia, a preparation method thereof, and a medicine or health food for preventing and treating hyperuric acid and hyperlipidemia. The Chinese medicine composition for preventing and treating hyperuric acid and hyperlipidemia of the present invention contains an extract of a Chinese medicine prescription, and the Chinese medicine prescription includes the following components in parts by weight: 3-20 parts of coix seeds, 5-40 parts of smilax glabra, 3-20 parts of plantain, 1-9 parts of atractylodes, 1-12 parts of cyathula, 1-9 parts of papaya, and 1-9 parts of hemp seeds. The Chinese medicine composition of the invention has the effects of removing dampness and water, diuresis and relieving stranguria, can significantly regulate the effects of hyperuric acid and hyperlipidemia, and has no toxic side effects when taken for a long time.

[0005] Although the above prescriptions use diuretic and stranguria-relieving drugs for the discharge of uric acid, they do not really solve the problem of elevated uric acid from the source. Traditional Chinese medicine believes that patients with hyperuricemia and gout have dysfunctional spleen and kidney functions of clear and turbid secretion, internal accumulation of phlegm and dampness, and multiple wind, cold, dampness and heat evil, coupled with excessive drinking, overeating of fatty and greasy foods, and improper work and rest in life, which leads to internal and external evil, phlegm and dampness combined with blood, turning into turbid toxins, blocking the meridians, flowing into joints, and invading the internal organs. Treatment should focus on removing dampness and resolving phlegm, purging turbidity, removing blood stasis and detoxifying, while taking into account regulating the spleen and kidney, warming yang and transforming qi. Therefore, there is a need for an anti-uric acid drug that can repair the overall function of the body from the source to eliminate and prevent the generation of phlegm, dampness, turbidity and blood stasis. Summary of the invention

[0006] In order to solve the above-mentioned deficiencies of the prior art, the present invention provides a Chinese medicine composition with anti-uric acid effect and a method for preparing its extract and its application in the field of preparing medicines or health products for preventing and treating hyperuricemia, and specifically adopts the following scheme: A traditional Chinese medicine composition with anti-uric acid effect comprises the following raw materials, measured by weight: 3-5 parts of chicory, 1.5-2.5 parts of platycodon grandiflorum and 1 part of mulberry linterus.

[0007] Hyperuricemia can be divided into damp-heat stasis type, stasis-heat obstruction type, phlegm turbidity obstruction type and liver-kidney yin deficiency type according to TCM dialectics. Hyperuricemia is caused by turbidity and stasis, so the treatment principle of "draining turbidity and removing stasis" should be adhered to, and the treatment should be modified according to the syndrome. Turbidity and stasis can be gradually drained, and blood uric acid will also decrease accordingly, so that the function of clear and turbid secretion is restored, and the patient tends to recover. The method of "draining turbidity and removing stasis" for treating gout by Zhu Liangchun, a master of traditional Chinese medicine, has been recognized and applied in clinical practice by many scholars and some famous old Chinese medicine practitioners, showing unique efficacy. After years of clinical practice, it has been shown that draining turbidity and removing stasis, washing away dirt, and getting rid of the old and bringing in the new can not only relieve pain, but also improve the internal environment of the human body, promote blood circulation, excrete and reduce uric acid. If the disease lasts for a long time and the qi and blood are not flowing smoothly, phlegm turbidity and blood stasis will accumulate in the meridians, causing joint pain, nodules, deformities and other symptoms. Evil lingers on to hurt the body, spleen and kidney yin deficiency, and finally leads to spleen and kidney deficiency, lingering dampness and toxins, great deficiency of righteousness, and physical weakness. Treatment should regulate the spleen and kidneys, strengthen the body and eliminate evil.

[0008] The Chinese medicine composition of the present invention selects chicory as the main drug. Chicory can upregulate the expression level of intestinal ABCG2, regulate intestinal flora, maintain the integrity of the intestinal barrier, and promote intestinal uric acid excretion; secondly, chicory promotes renal uric acid excretion and improves renal function by upregulating the expression of kidney OAT1 and OAT3 and downregulating URAT1 and GLUT9. Chicory enters the liver meridian, can clear the liver and promote gallbladder, and treat endogenous dampness and heat, and stagnation of liver and gallbladder. Pharmacological studies have shown that chicory can act on the liver, inhibit the activity of multiple purine metabolic enzymes, and then inhibit uric acid synthesis, effectively reducing uric acid levels. Chicory has anti-inflammatory activity, and can reduce the LPS / TLR4 axis inflammatory response by downregulating serum lipopolysaccharide (LPS) and TLR4 / NF-κB inflammatory pathways in the kidneys. It can also inhibit the NLRP3 signaling pathway, reduce the release of interleukin-1β, treat inflammation caused by uric acid, and significantly improve the symptoms of hyperuricemia. In addition, chicoric acid, a bioactive ingredient in chicory, can protect the liver and inhibit inflammation, and is particularly suitable for treating patients with hyperuricemia due to insufficient liver function.

[0009] The Chinese medicine composition of the present invention selects Platycodon grandiflorum as the adjuvant drug, Platycodon grandiflorum, which has rich edible value and medicinal value. The main components of Platycodon grandiflorum include polysaccharides, saponins, flavonoids and volatile oils, among which Platycodon grandiflorum polysaccharide is an important polysaccharide, which is formed by hundreds of monosaccharide molecules connected by glycosidic bonds. Platycodon grandiflorum polysaccharide has attracted much attention in the field of traditional Chinese medicine research, and it is widely used in anti-tumor, anti-oxidation, immune enhancement and hypoglycemia. Pharmacology has found that the main active ingredient of Platycodon grandiflorum, Platycodon grandiflorum saponin, also has multiple pharmacological effects such as anti-oxidation, anti-coagulation, hypolipidemic, anti-cancer, liver protection, and immune regulation. Platycodon grandiflorum saponin D can significantly improve the bone and cartilage damage of collagen arthritis mice, and reduce the level of myeloperoxidase (MPO) in the toes of mice; Platycodon grandiflorum saponin D pretreatment can significantly reduce serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL) and liver MDA levels, and significantly inhibit the increase of inflammatory factors, including TNF-α, IL-1β and IL-6. This can be used to treat inflammatory pain in gout patients with hyperuricemia.

[0010] The Chinese medicine composition of the present invention uses Phellinus igniarius as an adjuvant. Phellinus igniarius is a kind of medicinal and edible fungus with important pharmacological activity. Its chemical components mainly include polysaccharides, flavonoids, terpenes, steroids, etc. These components give Phellinus igniarius a variety of pharmacological effects, such as liver protection, anti-tumor, anti-oxidation, anti-inflammatory, immunomodulatory, antibacterial, antiviral and anti-cancer. It can also play an anti-inflammatory and immunomodulatory role by regulating multiple signal pathways. In terms of anti-oxidation, Phellinus igniarius can increase the expression of antioxidant enzymes and scavenge free radicals. Pharmacological experiments have shown that the alcohol extract of poplar mulberry igniarius has significant effects in in vitro anti-oxidation (DPPH, ABTS, etc.), anti-tumor (inhibiting the proliferation of liver cancer cells HepG2), hypoglycemic (inhibiting the activity of α-glucosidase and α-amylase), and uric acid reduction (inhibiting the activity of xanthine oxidase). Especially at a concentration of 3.0 mg / mL, the alcohol extract has an inhibition rate of 97.07% on xanthine oxidase, and an IC50 value of 0.85 mg / mL, which has a strong uric acid reduction effect. In addition, Phellinus igniarius has a strong immunomodulatory effect and minimal adverse reactions, so it has certain advantages over other chemical drugs. At present, foods and medicines made from Phellinus igniarius have gradually appeared in other countries. The chemical components with immunomodulatory activity in Phellinus igniarius mainly include Phellinus igniarius polysaccharides, phenols, terpenes, Phellinus igniarius extracts, etc. Phellinus igniarius can alleviate acrylamide-induced oxidative stress by reducing ROS and MMP in Caco-2 cells and increasing GSH, showing potential antioxidant activity. The new polysaccharide-protein complex extracted from Phellinus igniarius is an important biological response regulator for macrophages and NK cells, and can promote the proliferation of B cells. Therefore, Phellinus igniarius has a definite therapeutic effect on improving immunity in many major diseases.

[0011] Most patients with hyperuricemia suffer from improper diet, emotional damage, and lack of regulation, which lead to damp-heat stagnation, heat stagnation, or phlegm stagnation in the body, which ultimately causes poor circulation of Qi and blood, and the disease occurs due to stagnation. Therefore, the treatment mainly focuses on clearing and unblocking. According to different syndromes, the treatment may use methods such as clearing heat, dispersing blood stasis, or promoting Qi and resolving phlegm. In this prescription, chicory belongs to the stomach and large intestine meridians, and has the functions of clearing away heat and detoxifying, clearing the liver and promoting bile secretion, and promoting diuresis and reducing swelling. It is the main medicine. Platycodon grandiflorum is bitter, pungent, and slightly cold, and belongs to the lung meridian. It has the functions of descending qi and resolving phlegm, dispersing wind and dissipating heat. The two medicines are used together to clear and disperse. The qi-moving function of Platycodon grandiflorum can enhance the main medicine's functions of clearing the liver and gallbladder, promoting diuresis and reducing swelling. At the same time, the lungs are the upper source of water, and Platycodon grandiflorum can invigorate the lung qi, so that the lung qi can be promoted and ascended, and the body's water metabolism function can be enhanced by the method of "lifting the pot and opening the lid", thereby accelerating uric acid metabolism, removing dampness and dispersing heat, and resolving stasis and heat. In addition, patients with hyperuricemia often have a long course of disease, and those who have been ill for a long time often have blood. Morigari fungus belongs to the liver and kidney meridians and can enter the blood. This prescription uses it as an adjuvant to enhance the clearing, promoting, and dispersing functions of the two main and auxiliary medicines. The whole formula can be used together to mainly remove dampness and resolve phlegm, eliminate turbidity, resolve blood stasis and detoxify, while taking into account the lungs, kidneys, spleen and stomach, clearing away without hurting the body, warming the yang and transforming qi, repairing the body's overall function from the source, so as to eliminate and prevent the formation of phlegm, dampness, turbidity and blood stasis.

[0012] Furthermore, the following raw materials are also included in parts by weight: 3~4 parts of raw astragalus, 1.5~2 parts of siler, 2~2.5 parts of stephania tetrandra, 2~2.5 parts of stir-fried atractylodes, 1.5~2 parts of clematis, 1.5~2 parts of cinnamon twig, 1.5~2 parts of white peony root, 1.5~2 parts of red peony root, 2~2.5 parts of stir-fried atractylodes, 1.5~2 parts of salt-cured phellodendron, 2~2.5 parts of radix polygoni multiflori, 3~4 parts of late silkworm feces (package), 4~5 parts of stir-fried coix seed, 1.5~2 parts of chicken gizzard lining and 1.5~2 parts of tangerine peel.

[0013] Furthermore, the following raw materials are also included in parts by weight: 1~2 parts of perilla leaves, 1~2 parts of patchouli stems, 2~2.5 parts of stir-fried atractylodes, 4~5 parts of stir-fried coix seeds, 1~2 parts of stir-fried apricot kernels, 1~2 parts of Magnolia officinalis, 2~3 parts of Smilax glabra, 1~2 parts of Alisma orientalis, 1~2 parts of Trillium, 1~2 parts of Leonurus japonicus, 1~2 parts of Saposhnikovia divaricata, 1~2 parts of Stephania tetrandra, 2~2.5 parts of Polygonum multiflorum, 2~2.5 parts of Siegesbeckia officinalis, 1~2 parts of Alpinia oxyphylla and 1~2 parts of Amomum villosum.

[0014] Furthermore, the following raw materials are also included in parts by weight: 1~2 parts of Patchouli stem, 1~2 parts of Perilla stem, 2~3 parts of Artemisia capillaris, 1~2 parts of Scutellaria baicalensis, 1~2 parts of Peach kernel, 1~2 parts of Apricot kernel, 1~2 parts of Magnolia officinalis, 1~2 parts of Pinellia ternata, 5~6 parts of raw Coix seeds, 5~6 parts of stir-fried Coix seeds, 2~2.5 parts of Caulis Achyranthis Bidentatae, 1~2 parts of Citrus grandis peel, 1~2 parts of Areca catechu, 2~2.5 parts of Polygonum cuspidatum, 3~4 parts of Plantago seed (wrapped and decocted), 2~3 parts of Lycium barometz, 1~2 parts of Trillium gracile, 2~3 parts of Patrinia salsa, 3~4 parts of Liuyi powder (wrapped and decocted), 2~3 parts of stir-fried Citrus aurantium and 0.5~1 part of Rhubarb in wine.

[0015] Furthermore, the following raw materials are also included in parts by weight: 1~2 parts of Phellodendron chinense, 1~2 parts of Atractylodes lancea, 1~2 parts of Pinellia ternata, 2~2.5 parts of Peach Kernel, 2~2.5 parts of Notopterygium wilfordii, 1~2 parts of Shenqu, 2~2.5 parts of Honeysuckle, 2~2.5 parts of Forsythia suspensa, 1~2 parts of Eupolyphaga sinensis, 1~2 parts of Chuanxiong, 1~1.5 parts of Whole Insects and 1~2 parts of Aconiti Lateralis Preparata.

[0016] The present invention also discloses a method for preparing the extract of the above-mentioned Chinese medicine composition having anti-uric acid effect: S1. Weigh the Chinese medicine composition according to the weight ratio and place it in a casserole, add 300-500 mL of water, and soak for 15-30 minutes before decocting; S2, boiling the Chinese medicine composition in the casserole for 10-15 minutes; S3, filter out the drug residue and obtain the drug solution for later use; S4. Add water to the residue and boil it twice more. Separate the liquid medicine from the residue after each boiling and combine the liquid medicines to obtain the extract.

[0017] Application of the above-mentioned Chinese medicine composition with anti-uric acid effect in the preparation of medicines or health products for preventing and treating hyperuricemia.

[0018] Compared with the prior art, the present invention has the following beneficial effects: The generation of high uric acid is closely related to the endogenous turbid toxins and blood stasis, and the disorder of the clear and turbid metabolism of the spleen and kidney. Most patients with this disease have lost the function of spleen health, and have no power to raise the clear and lower the turbid; the kidney loses the ability of gasification, and the function of distinguishing the clear and turbid is dysfunctional. As a result, the turbid toxins are endogenous, retained in the blood, and spread with the blood, resulting in a series of pathological changes. Therefore, the principle of treatment should be to regulate the spleen and kidney, correct the root and clear the source. The Chinese medicine composition of the present invention is characterized by using Chinese medicine that is both medicinal and edible, which is safe and effective. Through the composite synergy of chicory, platycodon and mulberry linterus, it has the effects of anti-oxidation, anti-inflammatory, and improving immunity, which can not only improve symptoms, but also repair the overall function of the body from the source, to eliminate and prevent the generation of phlegm dampness, turbidity and blood stasis, thereby inhibiting and reducing the generation of uric acid. DETAILED DESCRIPTION

[0019] The technical solution of the present invention is further described below in conjunction with embodiments, but the protection scope of the present invention is not limited thereto.

[0020] Example 1 Clinical Case History Wu, male, 37 years old. Date of first diagnosis: March 14, 2023. The patient complained of intermittent swelling and pain in the first metatarsophalangeal joint of the left foot for 3 years. Three years ago, after drinking a lot of alcohol, the first metatarsophalangeal joint became red, swollen, hot and painful, the pain was unbearable, and walking was difficult. After taking painkillers on his own, the symptoms gradually eased. The swelling and pain in the posterior joint recurred, and were more obvious after fatigue. He went to the local hospital for treatment, and the uric acid was 570μmol / L, and he was diagnosed with "gout". After the patient controlled his diet, the blood uric acid level decreased, but the joint swelling and pain were intermittent, and the pain was tolerable.

[0021] Chief complaint: slight swelling and pain in the first metatarsophalangeal joint of the left foot, migratory pain in joints and muscles throughout the body, fatigue, poor sleep, paroxysmal dizziness, night sweats, no headache, normal appetite, normal bowel movements. A history of hypertension and dyslipidemia (currently taking valsartan capsules to control blood pressure). Dark red tongue with ecchymosis, thin yellow and slightly greasy fur, and a stringy, slippery, and fine pulse.

[0022] Diagnosis: Gout (deficiency of both Qi and blood, stagnation of dampness type).

[0023] Treatment method: Invigorate Qi and harmonize blood, dispel wind and dampness.

[0024] Prescription: 20g of raw Astragalus, 18g of Chicory, 15g of Platycodon grandiflorum, 6g of Phellinus igniarius, 12g of Saposhnikovia divaricata, 15g of Stephania tetrandra, 15g of stir-fried Atractylodes macrocephala, 12g of Clematidis, 12g of Cinnamomum cassia, 12g of White Peony Root, 12g of Red Peony Root, 15g of stir-fried Atractylodes lancea, 12g of Salted Phellodendron, 15g of Radix Dioscoreae, 20g of late silkworm feces (package), 30g of stir-fried Coix seeds, 12g of Chicken Gizzard Stone, 10g of Pi Pi. Decoction, 1 dose per day.

[0025] External washing prescription: Sophora flavescens 12g, Verbena officinalis 30g, Gleditsia sinensis 15g, Clematidis 15g, Saposhnikovia divaricata 15g, Stephania tetrandra 15g, Vinegar Corydalis 12g, Sodium Sulfate 15g. 7 doses, local fumigation, 1 dose per day.

[0026] After 7 doses of medicine, the patient's joint pain disappeared, dizziness and fatigue disappeared, night sweats were significantly reduced, and sleep improved. 14 doses of the previous prescription were made into granules for oral administration, 9g each time, twice a day, to consolidate the effect. The patient was advised to avoid fatty, sweet, greasy and raw and cold foods.

[0027] The TCM diagnosis of this case was gout, which was caused by deficiency of both qi and blood and stagnation of dampness. The patient usually had an irregular diet, which damaged the spleen and stomach in the middle jiao, and the source of qi and blood was insufficient, so he could not normally raise the clear and lower the turbid. Qi and blood could not be transformed into essence, but dampness, and the qi deficiency was unable to push and finally became stagnation. The dampness turned into heat after a long time, and then became damp heat, which was accumulated in the joints, so there was pain and discomfort in the joints all over the body. In the prescription, chicory can clear away heat and detoxify, clear the liver and promote bile, and promote diuresis and reduce swelling, which can effectively relieve joint pain; Platycodon grandiflorum can lower qi and resolve phlegm, dispel wind and dissipate heat. The combination of the two medicines can clear and disperse, promote uric acid metabolism, remove dampness and heat, and resolve stasis and heat; Phellinus versicolor belongs to the liver and kidney meridians, and can enter the blood, activate blood circulation, stop bleeding, and resolve phlegm. The combination of the three medicines can remove dampness, resolve phlegm, relieve pain, and relieve turbidity, resolve stasis and detoxify. In addition, Astragalus and Atractylodes macrocephala are used to invigorate the spleen and eliminate dampness, while Saposhnikovia divaricata and Stephania tetrandra dispel wind, Cinnamon twig, Red and White Peony Root harmonize blood, and Atractylodes macrocephala, Phellodendron chinense and Coix seed clear away dampness and heat. Looking at the whole prescription, it is urgent to treat the symptoms in case of emergency and treat the root cause in case of slow attack. In case of acute gout attack, the priority is to reduce swelling and relieve pain. Therefore, Chicory, Platycodon grandiflorum and Phellinus igniarius are used to eliminate dampness and resolve phlegm, relieve turbidity, resolve blood stasis and detoxify.

[0028] Example 2 Clinical history The patient, male, 29 years old, a programmer in a company, was first diagnosed on February 3, 2023. Chief complaint: joint pain throughout the body, recurring for 3 years, aggravated for 3 days. Medical history: The patient had sudden swelling and pain in the left ankle joint 3 years ago, and the pain was severe at night, and he needed to take Fenbid and Baifuning to relieve the pain. Since then, the migratory pain in the ankle, elbow, and knee joints has recurred, and the whole body feels heavy and uncomfortable. There is no obvious relationship with climate change. It often occurs when tired or eating carelessly. 3 days ago, the left knee joint was swollen and painful, red in color, with high skin temperature, and unable to walk. Physical examination showed scattered dark red subcutaneous nodules on the face and chest. The appetite is good, but there is sometimes abdominal distension and loose stools, and sleep is disturbed at night due to joint swelling and pain. The tongue is dark, the fur is thin, yellow and greasy, and the pulse is deep and astringent.

[0029] Syndrome differentiation: Spleen deficiency and excessive dampness, long-term depression turning into heat, damp-heat obstruction.

[0030] Treatment principle: Strengthen the spleen and eliminate dampness, clear away heat, assist yang and transform qi.

[0031] Prescription: 18g of chicory, 15g of platycodon, 6g of mulberry linterus, 10g of perilla leaf, 10g of patchouli stem, 15g of stir-fried atractylodes, 30g of stir-fried coix seed, 10g of stir-fried apricot, 12g of Magnolia officinalis, 18g of Smilax glabra, 12g of Alisma orientalis, 10g of Trillium, 10g of Leonurus japonicus, 12g each of Saposhnikovia divaricata and Stephania tetrandra, 15g of Polygonum multiflorum, 15g of Siegesbeckia officinalis, 9g of Alpinia oxyphylla, 6g of Amomum villosum, 7 doses.

[0032] Second visit: After taking the medicine, the joint pain was significantly relieved, the redness and swelling disappeared, and the chest and back pain symptoms were alleviated. Now the joints are still weak and stiff, the appetite is still good, the stomach is stuffy and bloated, the sleep is still good, the stool is loose and thin, and the urine is short and yellow. The tongue is dark red, the coating is thin and yellow, the root is greasy, and the pulse is deep, thin and astringent. The treatment is the same as above, with slight additions and subtractions: remove the perilla leaf, the herb Siegesbeckia, the motherwort, the schisandra ... At the same time, give Chinese medicine for local external washing, prescription: 15g each of Saposhnikovia divaricata, 12g of Angelica sinensis, 6g each of roasted Rumophora officinalis, 10g of Paniculata, 10g of Trachelospermum officinale, 20g of Kochia scoparia, 15g of Lonicera japonica, 14 doses.

[0033] Third diagnosis: After taking the medicine, the redness, swelling and pain in the knee joints have been relieved, but the limbs become sore and weak after standing for a long time, the appetite is good, and the stool is sometimes loose. The tongue is fat, the tip of the tongue is red, the coating is thin and white, and the pulse is deep and slippery. Syndrome differentiation: dampness and heat are gradually gone, but the deficiency of the body is becoming more and more obvious.

[0034] Treatment principle: Strengthen the spleen and strengthen the body, remove dampness and dredge the meridians. Prescription: 15g of Prince ginseng, 18g of chicory, 15g of Platycodon grandiflorum, 6g of Cortex Mori igniarius, 12g of stir-fried Atractylodes macrocephala, 20g of stir-fried Coix seed, 10g of stir-fried Apricot kernel, 12g of Magnolia officinalis flower, 10g of Pinellia ternata, 20g of Smilax glabra, 6g of Amomum villosum (added later), 15g of Dioscorea paniculata, 12g each of Saposhnikovia divaricata and Stephania tetrandra, 10g of Trillium, 15g of Caulis Sinomenii, 15g of Polygonum multiflorum, 15g of Leonurus japonicus, 15g of Polygonum cuspidatum, 10g of Paeonia suffruticosa, 12 doses.

[0035] Four examinations: After that, due to work stress, gout relapsed, left knee joint was not active, slightly red and swollen, pain was worse at night, fever, sweating, accompanied by fatigue. Diet was OK, sleep was poor, dreamy, abdominal distension, loose stools, yellow urine. The tongue coating was thin and yellow, the tip was red, there were teeth marks, and the pulse was deep and slippery. The treatment adhered to the previous method and prescription, focusing on clearing heat and dampness, unblocking meridians and relieving pain, adding Phellodendron chinense 10g, pine knot 15g, earthworm 12g, etc. And supplemented with tea to enhance the efficacy, it can be relieved quickly. Tea prescription: Pseudostellariae Radix 10g, Chicory 9g, Platycodon 6g, Phellinus 3g, Stir-fried Coix Seed 15g, Red Bean 15g, Magnolia Officinalis Flower 6g, Rose 6g, Corn Silk 15g, 10 doses.

[0036] Fifth diagnosis: After taking the medicine, the swelling and pain in the joints have disappeared, but standing for a long time, there is weakness and tightness, the discomfort in the stomach has been eliminated, the appetite is good, and the bowel movement is one row every morning. The tongue is fat and dark with tooth marks, and the fur is thin and yellow and greasy. It belongs to the phenomenon of clear damp heat and cold dampness. The treatment should be to invigorate qi and strengthen the spleen, dispel wind and dampness and dredge the meridians. Prescription: 20g of raw astragalus, 18g of chicory, 15g of platycodon, 6g of mulberry, 18g of tuckahoe, 20g of stir-fried coix seed, 10g of oriental water plantain, 10g of stir-fried cang and stir-fried atractylodes, 15g of green wind vine, 15g of trachelospermum officinale, 15g of radix polygoni multiflori, 10g of peach and apricot kernel, 12g of deer bite grass, 15g of pine knot, 12g of stephania tetrandra, 15g of honeysuckle vine, 15g of plantain, 6g of amomum (later), 4g of scorpion, 20 doses. The condition is stable after taking the medicine. The stool is 1 to 2 times a day, occasionally unformed. The tongue is pale, with a red tip, a thin white coating, a slightly greasy root, and a deep and slippery pulse. The effect is immediate, and the treatment is based on the previous method. The prescription is increased or decreased, and another 14 doses are taken. The doctor also advises to pay attention to the dietary taboos and regulate and consolidate the treatment. So far, uric acid and blood lipids are normal, and there has been no recurrence.

[0037] The patient in this case had been suffering from joint pain for more than 3 years, and it often occurred when he was tired or had a careless diet. The patient had been ill for a long time and was weak, and his spleen and stomach were damaged, so he had a good appetite, abdominal distension, and loose stools. These are all signs of spleen deficiency and dampness. The spleen governs transportation and transformation, which means that the spleen has the function of converting nutrients in food into fine substances such as qi, blood, and body fluids, and transporting them to various organs and tissues throughout the body. When the spleen and stomach are weak, the transportation and transformation function is weakened, and the nutrients in food cannot be fully transformed, resulting in insufficient production of qi, blood, and body fluids. In addition, spleen deficiency will also affect water metabolism, causing water retention and dampness, and the symptoms of spleen deficiency and dampness. Dampness turns into heat after a long time, and becomes damp heat, which accumulates in the joints, so there is pain and discomfort in the joints throughout the body. In the prescription, chicory clears heat and detoxifies, promotes diuresis and reduces swelling, which can effectively relieve joint pain; Platycodon grandiflorum descends qi and resolves phlegm, dispels wind and dissipates heat, so that dampness and heat are dispersed, and blood stasis and heat are resolved; long-term illness will lead to blood stasis, so mulberry yellow is used to promote blood circulation, stop bleeding, and transform fluid. The three medicines are used together to eliminate dampness, resolve phlegm, relieve pain, eliminate turbidity, resolve blood stasis and detoxify.

[0038] In addition, at the initial visit, perilla leaf, lotus stem, and Amomum villosum were used to eliminate dampness, stir-fried Atractylodes lancea and Magnolia officinalis were used to dry out dampness, and Smilax glabra and Alisma orientalis were used to eliminate dampness. Looking at the whole prescription, eliminating dampness is the primary purpose. When the joint pain was relieved during the follow-up visit, Pseudostellaria baicalensis, raw Astragalus, Poria cocos, stir-fried Atractylodes macrocephala were added to strengthen the spleen and replenish qi. Drugs such as Caulis Sinomenii, Trachelospermi Caulis, and Honeysuckle Caulis were used to relieve pain, and Scorpion and Rhizoma Polygoni Multiflori were used to promote blood circulation and relieve pain. All of them were added or subtracted according to the symptoms based on the three drugs of Chicory, Platycodon grandiflorum, and Phellinus versicolor to eliminate dampness and resolve phlegm, relieve turbidity, resolve blood stasis, and detoxify.

[0039] Example 3 Clinical history Patient, male, 38 years old. First visit on April 22, 2023. Recurrent swelling and pain in the big toe, ankle joint, and foot, and limited walking for 10 years. Usually likes meat, seafood, and beer. Ten years ago, the right big toe suddenly became red, swollen, and painful at night in the summer. The color was dark purple. He was diagnosed with gout after a checkup of high blood uric acid at a local hospital. Since then, the number of attacks has increased year by year. After taking colchicine, he stopped taking it due to vomiting, diarrhea, decreased vision, and hair loss. Current diagnosis: pain, redness, and swelling of the right big toe, accompanied by bitter and sticky mouth, good appetite, poor sleep, abdominal distension, relieved flatulence, loose and soft stools, sticky and uncomfortable, and yellow urine. Looking at the body, the body is plump, the tongue is fat, the texture is dark purple, the tongue coating is thick and greasy, and the pulse is deep and slippery.

[0040] Syndrome differentiation: Dampness, turbidity and blood stasis, causing congestion and stiffness in the joints.

[0041] Treatment method: Strengthen the spleen and eliminate dampness, clear away heat and relieve turbidity.

[0042] Prescription: 15g of chicory, 12g of platycodon, 5g of mulberry, 10g of patchouli, 10g of perilla, 15g of capillaris, 10g of scutellaria, 9g of peach kernel and apricot kernel, 10g of magnolia bark, 9g of pinellia tuber, 30g of raw coix seed and fried coix seed, 12g of scutellaria baicalensis, 10g of tangerine peel, 10g of betel nut, 12g of polygonum cuspidatum, 18g of plantain seed (wrapped and decocted), 15g of money grass, 8g of trifoliate mushroom, 15g of patrinia, 20g of liuyi powder (wrapped and decocted), 15g of fried immature bitter orange, 3g of wine rhubarb. 7 doses. Decoction, 1 dose per day.

[0043] Second visit on May 29, 2023: After taking the medicine, the swelling and pain in the right toe joints were significantly relieved, the bitter taste in the mouth was reduced, the abdominal distension disappeared, and the bowel movements were smoother than before. In recent days, the diet has been strictly controlled. The tongue is fat, dark purple, the yellow greasy fur gradually disappears, and the pulse is deep and slippery. Since the relief has been seen, the front is advancing and retreating. In the summer, it is easy to sweat due to high temperature, so it is advisable to replenish qi to consolidate it, regulate the spleen to remove dampness and clear heat. Remove the Patchouli, Perilla Stem, Plantago Seed, and Wine Rhubarb from the above prescription, and add 30g of Golden Sparrow Root, 12g of Stir-fried Atractylodes, and 30g of Smilax. 14 doses.

[0044] Third visit on June 15, 2023: 10 days ago, due to fatigue from a business trip, the patient had a swelling and pain attack in the left toe joints, which lasted for 3 to 5 days and then eased. The patient felt that the pain level and duration were reduced compared to before. His appetite was good, his sleep was getting better, and his bowel movements were getting more regular. His tongue was medium in size, dark in texture, with a thin yellow fur coating and a deep and slippery pulse. Treatment principle: Strengthen the spleen and dry dampness, dispel wind and clear heat, and assist with promoting blood circulation and unblocking collaterals. Prescription: 30g of golden broom root, 15g of chicory, 12g of platycodon, 5g of mulberry lindera, 15g of radix scutellariae, 15g of silkworm feces (wrapped and decocted), 30g of smilax glabra, 12g of oriental rhizome, 10g of amomum villosum (added later), 15g of scutellaria baicalensis, 10g of siler, 15g of fangji, 12g of stir-fried shenqu, 15g of motherwort, 15g of stir-fried atractylodes and atractylodes, 20g of millettia reticulata, 10g of phellodendron, 12g of magnolia officinalis flower, 20g of raw coix seed and stir-fried coix seed, 20g of raw barley sprout and raw malt, 14 doses.

[0045] Fourth visit on June 28, 2023: After taking the medicine, the pain in the right foot joint did not occur, the appetite was good, the sleep was good, the morning mouth was bitter, the stool was not formed, the urine was regular, the tongue was medium, the texture was dark and stagnant, the tongue coating was thin and white, and the pulse was deep and slippery. The treatment was based on the previous method, and the original prescription was modified: the raw coix seed and the fried coix seed were changed to 30g each, the Millettia reticulata was changed to 15g, and the oriental rhizome was changed to 15g. Remove the phellodendron, add 10g of bamboo juice and pinellia, and 2 slices of ginger as an introduction. 14 doses.

[0046] Fifth visit on August 14, 2023: The swelling and pain in the toe joints did not recur. Occasionally, the left big toe joint became stiff, but it returned to normal after resting for the second day. The bitter taste in the mouth has been eliminated, the abdomen is bloated after eating, the whole body feels heavy and sour after dinner, and the bowel movements are normal. The tongue is medium, dark, with a thin white coating, and the pulse is deep, stringy and slippery. Gout has not recurred for more than a month, but it still needs to be consolidated to strengthen the spleen and replenish qi, remove dampness and clear heat. Prescription: 30g of golden broom root, 15g of chicory, 12g of platycodon, 5g of mulberry, 15g each of stir-fried atractylodes and atractylodes, 15g of scutellaria baicalensis, 10g of tribulus truncatum, 15g of silkworm feces (package), 12g of oriental rhizome, 20g of smilax glabra, 20g of raw coix seed and stir-fried coix seed, 12g of stir-fried siler, 12g of stir-fried fangji, 8g of stir-fried phellodendron, 12g each of the three fried herbs, 12g of magnolia bark, 15g of millet vine, 15g of plantain seed (packaged and decocted), 15g of motherwort, 10g of amomum villosum (added later). 14 doses are taken to cure the disease.

[0047] The patient is a middle-aged male who likes meat, seafood, and beer. He has an irregular diet and damages his spleen and stomach. He was diagnosed with gout 10 years ago, and the number of attacks has increased year by year, with a long course of disease. He now has a bitter and sticky mouth, loose and soft stools, sticky and uncomfortable stools, and yellow urine, which are manifestations of dampness and heat in the middle jiao. Dampness and heat accumulate in the spleen and stomach, and the spleen and stomach are blocked, and pathological changes of dampness and heat symptoms can be seen throughout the body. The tongue and pulse are both supporting evidence. Comprehensive pulse and symptoms, four examinations combined, the syndrome is diagnosed as dampness, turbidity, blood stasis, and joints. In the initial and follow-up visits, chicory is used to clear heat and detoxify, diuretic and detumescence, which can effectively relieve joint pain; Platycodon grandiflorum descends qi and resolves phlegm, dispels wind and dissipates heat, so that dampness, heat and blood stasis are resolved; long-term illness will inevitably cause blood stasis, so mulberry yellow is used to promote blood circulation, stop bleeding, and resolve fluid. The three medicines are used together to remove dampness, resolve phlegm, relieve pain, and relieve turbidity, resolve blood stasis and detoxify. Patchouli and Perilla frutescens are added to remove dampness with aromatics; Magnolia officinalis and Pinellia ternata are used to remove dampness; Artemisia capillaris, Scutellaria baicalensis, Areca nut and Polygonum cuspidatum are used to remove dampness and jaundice, clear away heat and detoxify; Plantago asiatica and Lysimachia chinensis are used to remove dampness and reduce swelling; Caulis Sinomenii drench the meridians and relieve pain; Patrinia chinensis and Liuyi powder are used to remove heat and dampness; Stir-fried Citrus aurantium and Rhubarb are used to clear the abdomen and remove dampness. All the medicines are used together to strengthen the spleen and remove dampness, clear away heat and expel turbidity.

[0048] Example 4 Clinical history Wang, male, 43 years old. First visit on July 15, 2023. Two years ago, the left toe and second toe became red, swollen and painful for no obvious reason, and he could not walk. He was diagnosed with gout by the hospital, and his symptoms improved significantly after colchicine treatment. After that, the symptoms recurred every time he ate seafood and meat, the pain was unbearable, and he could not walk. He had to take colchicine to improve his symptoms. One week ago, gout recurred due to eating meat. After colchicine treatment, the symptoms did not improve significantly, the toes were red, swollen and painful, and walking was difficult. The blood uric acid test was 725μmol / L. Ruddy complexion, fat body, red tongue with white fur, and slippery pulse.

[0049] TCM diagnosis: Bi syndrome (painful arthralgia, internal accumulation of damp-heat and blood stasis).

[0050] Treatment method: Clear away heat and dampness, promote blood circulation and dredge meridians.

[0051] Prescription: 35g of chicory, 15g of platycodon, 9g of mulberry linterus, 15g of phellodendron, 15g of atractylodes, 15g of pinellia tuber, 20g of peach kernel, 20g of angelica root, 15g of Shenqu, 20g of honeysuckle, 20g of forsythia, 15g of earthworm, 15g of chuanxiong, 10g of whole worm, 15g of Chuanwu. 10 doses, decocted in water, 1 dose per day, divided into morning and evening.

[0052] Second visit: The redness, swelling and pain have been alleviated, but the patient is still unable to walk. Add 20g of Smilax glabra and 30g of raw coix seed to the above prescription. 10 doses, same as above.

[0053] Third visit: The redness and swelling were further reduced, the pain was significantly reduced, the patient was able to walk, and the uric acid test was 525mmol / L. After taking the above medicine for 15 doses, the symptoms were basically eliminated.

[0054] The patient is a middle-aged male who was diagnosed with gout 2 years ago. After that, the symptoms recurred every time he ate seafood and meat. The initial gout attack was unbearable. Spleen deficiency and dampness are excessive, and long-term stagnation leads to stagnation. The key disease location of dampness stagnation is the middle jiao, which is the hub of the movement of qi. The key pathogenesis of dampness stagnation is that stagnation leads to stagnation, and stagnation leads to heat. Because of its fiery nature, it promotes the excessive rise of the qi in the upper jiao, the inability of the qi in the middle jiao to condense, and the excessive descent of the qi in the lower jiao, which leads to clinical symptoms throughout the body. This case is diagnosed as arthralgia, painful arthralgia, and internal stagnation of damp-heat and blood stasis. The prescription uses 35g of chicory, 15g of platycodon, and 9g of mulberry linteus. Chicory clears heat and detoxifies, diuresis and reduces swelling, and can effectively relieve joint pain; platycodon descends qi and resolves phlegm, dispels wind and dissipates heat, so that dampness and heat are dispersed, and stasis and heat are resolved; long-term illness will lead to stasis, so mulberry linteus is used to promote blood circulation, stop bleeding, and resolve fluid. The three medicines are used together to remove dampness, resolve phlegm, relieve pain, and relieve turbidity, resolve stasis and detoxify. Combined with peach kernel, earthworm, Chuanxiong, whole worm, Chuanwu, honeysuckle, forsythia, phellodendron, heat-clearing and detoxification, and Notopterygium, Atractylodes, and Pinellia to remove dampness, the whole formula clears heat and dampness, promotes blood circulation and dredges. The prescription is symptomatic and has significant efficacy.

Claims

1. A Chinese medicine composition having an anti-uric acid effect, characterized in that: The raw materials are as follows, measured by weight: 3-5 parts of chicory, 1.5-2.5 parts of platycodon grandiflorum and 1 part of mulberry linterus.

2. The Chinese medicine composition according to claim 1, characterized in that: In parts by weight, the following raw materials are also included: 3~4 parts of raw astragalus, 1.5~2 parts of siler, 2~2.5 parts of stephania tetrandra, 2~2.5 parts of stir-fried atractylodes, 1.5~2 parts of clematis, 1.5~2 parts of cinnamon twig, 1.5~2 parts of white peony root, 1.5~2 parts of red peony root, 2~2.5 parts of stir-fried atractylodes, 1.5~2 parts of salt-cured phellodendron, 2~2.5 parts of radix polygoni multiflori, 3~4 parts of late silkworm feces (package), 4~5 parts of stir-fried coix seed, 1.5~2 parts of chicken gizzard lining and 1.5~2 parts of tangerine peel.

3. The Chinese medicine composition according to claim 1, characterized in that In parts by weight, the following raw materials are also included: 1~2 parts of perilla leaves, 1~2 parts of patchouli stems, 2~2.5 parts of stir-fried atractylodes, 4~5 parts of stir-fried coix seeds, 1~2 parts of stir-fried apricot kernels, 1~2 parts of Magnolia officinalis, 2~3 parts of Smilax glabra, 1~2 parts of Alisma orientalis, 1~2 parts of Trillium, 1~2 parts of Leonurus japonicus, 1~2 parts of Saposhnikovia divaricata, 1~2 parts of Stephania tetrandra, 2~2.5 parts of Polygonum multiflorum, 2~2.5 parts of Siegesbeckia officinalis, 1~2 parts of Alpinia oxyphylla and 1~2 parts of Amomum villosum.

4. The Chinese medicine composition according to claim 1, characterized in that: In parts by weight, the following raw materials are also included: 1~2 parts of Patchouli stem, 1~2 parts of Perilla stem, 2~3 parts of Artemisia capillaris, 1~2 parts of Scutellaria baicalensis, 1~2 parts of Peach kernel, 1~2 parts of Apricot kernel, 1~2 parts of Magnolia officinalis, 1~2 parts of Pinellia ternata, 5~6 parts of raw Coix seeds, 5~6 parts of stir-fried Coix seeds, 2~2.5 parts of Caulis Achyranthis Bidentatae, 1~2 parts of Citrus grandis peel, 1~2 parts of Areca catechu, 2~2.5 parts of Polygonum cuspidatum, 3~4 parts of Plantago seed (wrapped and decocted), 2~3 parts of Lycium barometz, 1~2 parts of Trillium gracile, 2~3 parts of Patrinia salsa, 3~4 parts of Liuyi powder (wrapped and decocted), 2~3 parts of stir-fried Citrus aurantium and 0.5~1 part of Rhubarb in wine.

5. The Chinese medicine composition according to claim 1, characterized in that: In parts by weight, the following raw materials are also included: 1~2 parts of Phellodendron chinense, 1~2 parts of Atractylodes lancea, 1~2 parts of Pinellia ternata, 2~2.5 parts of Peach Kernel, 2~2.5 parts of Notopterygium wilfordii, 1~2 parts of Shenqu, 2~2.5 parts of Honeysuckle, 2~2.5 parts of Forsythia suspensa, 1~2 parts of Eupolyphaga sinensis, 1~2 parts of Chuanxiong, 1~1.5 parts of Whole Insects and 1~2 parts of Aconiti Lateralis Preparata.

6. A method for preparing an extract of the Chinese medicine composition having an anti-uric acid effect according to any one of claims 1 to 5, characterized in that: The steps include: S1. Weigh the Chinese medicine composition according to the weight ratio and place it in a casserole, add 300-500 mL of water, and soak for 15-30 minutes before decocting; S2, boiling the Chinese medicine composition in the casserole for 10-15 minutes; S3, filter out the drug residue and obtain the drug solution for later use; S4. Add water to the residue and boil it twice more. Separate the liquid medicine from the residue after each boiling and combine the liquid medicines to obtain the extract.

7. Use of the Chinese medicine composition with anti-uric acid effect according to any one of claims 1 to 5 in the preparation of medicines or health products for preventing and treating hyperuricemia.