Polypeptide synthesizer reaction kettle

Abstract

The invention relates to a polypeptide synthesizer reaction kettle, which comprises: a reaction kettle tank body, the reaction kettle tank body is provided with a reaction chamber and a discharge port, and the discharge port is arranged at the bottom of the reaction kettle tank body and is communicated with the reaction chamber; the switch cover is positioned at the bottom of the outer side of the reaction kettle tank body and can open or close the discharge hole; the driving mechanism is arranged on the outer side of the reaction kettle tank body and connected with the switch cover, and the driving mechanism drives the switch cover to move relative to the reaction kettle tank body so as to open or close the discharge port; the locking mechanism is arranged on the outer side of the reaction kettle tank body, and after the switch cover closes the discharging opening, the locking mechanism can be connected with the switch cover and the reaction kettle tank body in a locking or unlocking mode. A locking mechanism is arranged on the outer side of the reaction kettle tank body, and the switch cover and the reaction kettle tank body are unlocked or locked through the locking mechanism. The switch cover and the reaction kettle tank body are reliably locked through the locking mechanism, so that the switch cover is prevented from being opened by mistake in reaction production, the safety is improved, and the use performance and the production efficiency are ensured.

Description

Technical Field

[0001] The present application relates to the technical field of synthesis equipment, and in particular to a peptide synthesizer reaction kettle. Background Art

[0002] A reactor is broadly understood as a container for physical or chemical reactions. The heating, evaporation, cooling and low-speed mixing functions required by the process are achieved through the structural design and parameter configuration of the container. A stirring paddle is provided inside the reactor for stirring and accelerating the reaction. The reaction solution and solid reactants are mixed and reacted in the reactor under the action of the stirring paddle.

[0003] The reactor is a container for peptide synthesis reaction and is an essential equipment in peptide production. The reactor is generally composed of upper and lower covers and the main body of the reactor. The upper and lower covers generally have pipelines for gas and liquid in and out, and have the function of convenient connection with the cavity and good sealing, so as to facilitate operation and cleaning. At present, the process of opening and closing the lower cover of the reactor is complicated, and there is a situation of accidental opening during the production process, which affects production efficiency. Summary of the invention

[0004] Based on this, it is necessary to provide a peptide synthesizer reactor to address the problem that the lower cover of the current reactor is accidentally opened during the production process, which can avoid the switch cover from being accidentally opened, ensure the performance and production efficiency of the peptide synthesizer reactor, and has a simple structure, convenient and practical.

[0005] A peptide synthesizer reactor, comprising:

[0006] A reactor tank body, wherein the reactor tank body has a reaction chamber and a discharge port, wherein the discharge port is arranged at the bottom of the reactor tank body and communicates with the reaction chamber;

[0007] A switch cover is located at the bottom of the outer side of the reactor tank body and can open or close the discharge port;

[0008] a driving mechanism, which is disposed on the outside of the reactor tank body and connected to the switch cover, and the driving mechanism drives the switch cover to move relative to the reactor tank body to open or close the discharge port; and

[0009] The locking mechanism is arranged on the outside of the reactor tank body, and the locking mechanism can lock or unlock the switch cover and the reactor tank body. After the switch cover closes the discharge port, the locking mechanism can lock the switch cover to the reactor tank body.

[0010] In one embodiment of the present application, the reactor tank body further comprises a fixing flange, which is arranged at the bottom of the reactor tank body and located at the edge of the discharge port;

[0011] The fixing flange is arranged corresponding to the switch cover, and the locking mechanism can lock or unlock the switch cover to the fixing flange.

[0012] In one embodiment of the present application, the locking mechanism includes a first locking body, a second locking body and a fastener, the first locking body is arranged on the switch cover, the second locking body is arranged on the fixing flange and is arranged corresponding to the first locking body;

[0013] The fastener passes through the first locking body and is installed in the second locking body.

[0014] In one embodiment of the present application, one of the first locking body and the second locking body has a mounting cavity, and the other of the first locking body and the second locking body is placed in the mounting cavity;

[0015] And / or, the first locking body has a first mounting groove, the second locking body has a second mounting groove, the end of the switch cover is located in the first mounting groove and abuts the first mounting groove, and the end of the fixing flange is located in the second mounting groove and abuts the second mounting groove.

[0016] In one embodiment of the present application, the first locking body has a first fixing portion, the switch cover has a first matching portion corresponding to the first fixing portion, the first fixing portion and the first matching portion are fixedly connected, and the first fixing portion and the first matching portion are a matching structure of a protrusion and a groove;

[0017] And / or, the second locking body has a second fixing portion, the fixing flange has a second matching portion corresponding to the second fixing portion, the second fixing portion and the second matching portion are fixedly connected, and the second fixing portion and the second matching portion are a matching structure of a protrusion and a groove.

[0018] In one embodiment of the present application, the locking mechanism includes a locking drive, a locking column and a third locking body, the third locking body can be rotatably sleeved on the fixing flange and covers the switch cover, and the output end of the locking drive is connected to the third locking body;

[0019] The locking column is arranged on the edge of the switch cover and protrudes radially. The third locking body has a locking groove. When the locking drive drives the third locking body to rotate, the locking column can move into or out of the locking groove to lock or unlock the switch cover and the fixing flange.

[0020] In one embodiment of the present application, the locking groove includes a first groove body and a second groove body, the first groove body axially penetrates to the bottom of the third locking body, the second groove body extends circumferentially and communicates with the first groove body, and when the third locking body rotates, the first groove body and the second groove body can move along the locking column to lock or unlock the switch cover to the fixing flange;

[0021] And / or, the locking groove has a guide surface, which is arranged at an angle, and the guide surface is used to guide the locking groove to move along the locking column, so that the switch cover is close to or away from the fixing flange, so as to lock or unlock the switch cover to the fixing flange.

[0022] In one embodiment of the present application, there are multiple locking columns, and the multiple locking columns are evenly distributed along the circumference of the switch cover, and each locking column corresponds to one locking groove;

[0023] And / or, the locking mechanism also includes a mounting seat, the mounting seat is arranged on the reactor tank body, the locking drive is arranged on the mounting seat, the output end of the locking drive is connected to the third locking body, and the locking drive is a cylinder, a hydraulic cylinder or a motor.

[0024] In one embodiment of the present application, the driving mechanism includes a driving component and a switching component, wherein the driving component is disposed on the outside of the reactor tank body, the switching component is movably disposed on the bottom of the reactor tank body, and the switching component is also connected to the switch cover;

[0025] The output end of the driving component is connected to one end of the adapter component, and the driving component can drive the adapter component to move relative to the reactor tank body, so that the adapter component drives the switch cover to open or close the discharge port.

[0026] In one embodiment of the present application, the peptide synthesizer reactor further includes a pressure relief mechanism, which includes a pressure relief pipe and a pressure relief valve, the pressure relief pipe is provided in the reactor tank body and communicates with the reaction chamber, and the pressure relief valve is provided in the pressure relief pipe;

[0027] And / or, the reactor tank body further comprises a feed inlet, the feed inlet is located at the top of the reactor tank body, and the peptide synthesizer reactor further comprises a stirring mechanism, the stirring mechanism is sealed at the feed inlet and extends into the reaction chamber.

[0028] After adopting the above technical solution, this application has at least the following technical effects:

[0029] The peptide synthesizer reactor of the present application has a discharge port connected to the reaction chamber at the bottom of the reactor tank body, a switch cover is arranged at the bottom of the outer side of the reactor tank body, a driving mechanism is arranged at the outer side of the reactor tank body, the driving mechanism is connected to the switch cover, and the driving mechanism can drive the switch cover to move relative to the reactor tank body so that the switch cover can open or close the discharge port. Moreover, a locking mechanism is arranged at the outer side of the reactor tank body, and when the switch cover closes the discharge port, the locking mechanism can lock the switch cover and the reactor tank body to close, so as to ensure that the switch cover reliably closes the reactor tank body.

[0030] The peptide synthesizer reactor is provided with a locking mechanism on the outside of the reactor tank body, and the switch cover and the reactor tank body are unlocked or locked by the locking mechanism. When the switch cover is closed, the locking mechanism can lock the switch cover and the reactor tank body to ensure that the switch cover can effectively close the discharge port, thereby ensuring that the peptide synthesizer reactor can normally carry out reaction production. After the production is completed, the locking mechanism unlocks the switch cover, and the driving mechanism can drive the switch cover to open for operations such as unloading. The peptide synthesizer reactor achieves reliable locking between the switch cover and the reactor tank body through the locking mechanism to avoid the switch cover being accidentally opened during the reaction production, improve safety, and ensure the performance and production efficiency of the peptide synthesizer reactor. At the same time, the peptide synthesizer reactor has a simple structure, which is convenient and practical. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] FIG1 is a front view of a peptide synthesizer reaction kettle in the first embodiment of the present application.

[0032] FIG. 2 is a front view of a peptide synthesizer reaction kettle in the second embodiment of the present application.

[0033] FIG3 is a partial enlarged view of the peptide synthesizer reactor at position A shown in FIG1 .

[0034] FIG. 4 is a partial enlarged view of the peptide synthesizer reactor at position B shown in FIG. 2 .

[0035] FIG. 5 is a bottom view of the peptide synthesizer reaction kettle shown in FIG. 2 .

[0036] Wherein: 100, peptide synthesizer reactor; 110, reactor tank; 111, fixing flange; 1111, second matching part; 120, switch cover; 121, first matching part; 130, driving mechanism; 131, driving component; 132, adapter component; 1321, first connecting arm; 1322, second connecting arm; 133, connecting component; 140, locking mechanism; 141, first locking body; 1411, first locking body Groove; 1412, mounting cavity; 1413, first fixing portion; 142, second locking body; 1421, second mounting groove; 1422, second fixing portion; 143, fastener; 144, locking drive; 145, third locking body; 1451, locking groove; 14511, first groove body; 14512, second groove body; 14513, guide surface; 146, locking column; 147, mounting seat; 160, stirring mechanism. DETAILED DESCRIPTION

[0037] In order to make the above-mentioned purposes, features and advantages of the present application more obvious and easy to understand, the specific implementation methods of the present application are described in detail below in conjunction with the accompanying drawings. In the following description, many specific details are set forth to facilitate a full understanding of the present application. However, the present application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without violating the connotation of the present application, so the present application is not limited by the specific embodiments disclosed below.

[0038] In the description of the present application, it should be understood that if the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. appear, the orientation or position relationship indicated by these terms is based on the orientation or position relationship shown in the accompanying drawings, which is only for the convenience of describing the present application and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present application.

[0039] In addition, if the terms "first" or "second" appear, these terms are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include at least one of the features. In the description of this application, if the term "plurality" appears, the meaning of "plurality" is at least two, such as two, three, etc., unless otherwise clearly and specifically defined.

[0040] In this application, unless otherwise clearly specified and limited, if the terms "installed", "connected", "connected", "fixed" and the like appear, these terms should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integrated connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise clearly defined. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to the specific circumstances.

[0041] In the present application, unless otherwise clearly specified and limited, if there is a description that a first feature is "on" or "below" a second feature, etc., or the like, it may mean that the first and second features are in direct contact, or that the first and second features are in indirect contact through an intermediate medium. Moreover, the first feature being "above", "above" and "above" the second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. The first feature being "below", "below" and "below" the second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.

[0042] It should be noted that if an element is referred to as being "fixed to" or "disposed on" another element, it may be directly on the other element or there may be a central element. If an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be a central element at the same time. If any, the terms "vertical", "horizontal", "upper", "lower", "left", "right" and similar expressions used in this application are for illustrative purposes only and do not represent the only implementation method.

[0043] Referring to FIG. 1 and FIG. 2 , the present application provides a peptide synthesizer reactor 100. FIG. 1 is a front view of the peptide synthesizer reactor 100 in the first embodiment of the present application, and FIG. 2 is a front view of the peptide synthesizer reactor 100 in the second embodiment of the present application. The peptide synthesizer reactor 100 is mainly used for producing peptide products and conducting in-depth research and development of peptide products. Of course, in other embodiments of the present application, the peptide synthesizer reactor 100 can also be used to produce other types of drugs or products.

[0044] It is understandable that the reactor is a container for carrying out peptide synthesis reaction and is an essential equipment in peptide production. At present, the process of opening and closing the lower cover of the reactor is complicated, and there is a situation of accidental opening during the production process, which affects the production efficiency. To this end, the present application provides a new type of peptide synthesizer reactor 100, which can avoid the switch cover 120 from being opened by mistake, improve safety, ensure the performance and production efficiency of the peptide synthesizer reactor 100, and has a simple structure, which is convenient and practical. The specific structure of the peptide synthesizer reactor 100 of an embodiment is introduced below.

[0045] Referring to FIG. 1 and FIG. 2 , in one embodiment, a peptide synthesizer reactor 100 includes a reactor tank body 110, a switch cover 120, a driving mechanism 130, and a locking mechanism 140. The reactor tank body 110 has a reaction chamber and a discharge port, and the discharge port is arranged at the bottom of the reactor tank body 110 and communicates with the reaction chamber. The switch cover 120 is located at the bottom of the outer side of the reactor tank body 110 and can open or close the discharge port. The driving mechanism 130 is arranged at the outer side of the reactor tank body 110 and connected to the switch cover 120. The driving mechanism 130 drives the switch cover 120 to move relative to the reactor tank body 110 to open or close the discharge port. The locking mechanism 140 is arranged at the outer side of the reactor tank body 110. The locking mechanism 140 locks or unlocks the switch cover 120 and the reactor tank body 110. After the switch cover 120 closes the discharge port, the locking mechanism 140 can lock the switch cover 120 to the reactor tank body 110.

[0046] The reactor tank body 110 is the main structure of the peptide synthesizer reactor 100. The reactor tank body 110 is hollow, and the hollow cavity is the reaction chamber. The material can enter the reaction chamber of the reactor tank body 110 and react and produce in the reaction chamber. The bottom of the reactor tank body 110 has a discharge port, which is connected to the reaction chamber. After the material is produced in the reaction chamber, the material is discharged through the discharge port.

[0047] The switch cover 120 is movably located at the bottom of the outer side of the reactor tank body 110, and the switch cover 120 can open or close the discharge port when it moves. Before the production starts, the switch cover 120 can movably close the discharge port, and the material can be subjected to production operations in the reaction chamber of the reactor tank body 110, such as feeding, stirring, reacting, filtering, washing, etc. After the production is completed, the switch cover 120 can movably open the discharge port to perform the discharge operation.

[0048] The movement of the switch cover 120 is driven by the driving mechanism 130. The driving mechanism 130 is arranged on the outside of the reactor tank body 110, and the output end of the driving mechanism 130 is connected to the switch cover 120. The driving mechanism 130 can be connected to the upper computer for transmission. Before the start of production and after the completion of production, the upper computer can automatically control the driving mechanism 130 to drive the switch cover 120 to move, so as to control the switch cover 120 to close or open the discharge port, thereby simplifying the opening and closing process of the switch cover 120 and facilitating the opening and closing of the switch cover 120. Of course, the user can also operate the upper computer to control the driving mechanism 130 to drive the switch cover 120 to move in a certain production process, so as to open or close the discharge port.

[0049] In order to achieve reliable locking when the switch cover 120 closes the discharge port, the peptide synthesizer reactor 100 of the present application is also provided with a locking mechanism 140, which is arranged on the outside of the reactor tank body 110 and located at the bottom of the reactor tank body 110. The locking mechanism 140 can be connected to the switch cover 120 or detached from the switch cover 120 to lock or unlock the switch cover 120 to the reactor tank body 110. In this way, after the switch cover 120 closes the discharge port, the locking mechanism 140 locks and connects the switch cover 120 and the reactor tank body 110 to reliably fix the switch cover 120 to the reactor tank body 110, prevent the switch cover 120 from being opened by mistake, improve safety, and improve production efficiency. When it is necessary to open the switch cover 120, first disengage the locking mechanism 140 from the switch cover 120 to unlock the switch cover 120 from the reactor tank body 110, and then the switch cover 120 can be controlled to open.

[0050] Before the production of the peptide synthesizer reactor 100 of the present application begins, the driving mechanism 130 drives the switch cover 120 to close the discharge port, and the locking mechanism 140 is used to lock and connect the switch cover 120 and the reactor tank body 110, so as to reliably fix the switch cover 120 to the reactor tank body 110. Subsequently, the material enters the reaction chamber of the reactor tank body 110, and the production operation is carried out. After the production is completed, the locking mechanism 140 is disengaged from the switch cover 120 to unlock the switch cover 120 from the reactor tank body 110, and then the switch cover 120 can be controlled to open the discharge port, and the discharge operation can be carried out through the discharge port. After the discharge is completed, the reactor tank body 110 and the switch cover 120 are cleaned, and after the cleaning is completed, the peptide synthesizer reactor 100 enters the standby state.

[0051] The peptide synthesizer reactor 100 of the above embodiment is provided with a locking mechanism 140 on the outside of the reactor tank body 110, and the locking mechanism 140 is used to unlock or lock the switch cover 120 and the reactor tank body 110. When the switch cover 120 is closed, the locking mechanism 140 can lock and connect the switch cover 120 and the reactor tank body 110, ensuring that the switch cover 120 can effectively close the discharge port, thereby ensuring that the peptide synthesizer reactor 100 can normally carry out reaction production. After the production is completed, the locking mechanism 140 unlocks the switch cover 120, and the driving mechanism 130 can drive the switch cover 120 to open for operations such as unloading. The peptide synthesizer reactor 100 realizes reliable locking between the switch cover 120 and the reactor tank body 110 through the locking mechanism 140, so as to avoid the switch cover 120 being opened by mistake during the reaction production, improve safety, and ensure the use performance and production efficiency of the peptide synthesizer reactor 100. At the same time, the peptide synthesizer reactor 100 has a simple structure, convenient and practical operation.

[0052] Referring to FIG. 1 and FIG. 2 , in one embodiment, the driving mechanism 130 includes a driving component 131 and an adapter component 132. The driving component 131 is disposed on the outside of the reactor tank body 110, and the adapter component 132 is movably disposed at the bottom of the reactor tank body 110. The adapter component 132 is also connected to the switch cover 120. The output end of the driving component 131 is connected to one end of the adapter component 132. The driving component 131 can drive the adapter component 132 to move relative to the reactor tank body 110, so that the adapter component 132 drives the switch cover 120 to open or close the discharge port.

[0053] The driving component 131 is a power source for controlling the movement of the switch cover 120. The driving component 131 is fixedly arranged on the outside of the reactor tank body 110. The output end of the driving component 131 can be connected to the adapter component 132. The adapter component 132 can be movably arranged at the bottom of the reactor tank body 110. The adapter component 132 is also connected to the switch cover 120. In this way, when the driving component 131 outputs movement, the driving component 131 can drive the adapter component 132 to move relative to the reactor tank body 110, and then the adapter component 132 can drive the switch cover 120 to move in or out of the discharge port, so that the discharge port of the reactor tank body 110 is opened or closed.

[0054] In this embodiment, the adapter component 132 drives the switch cover 120 to move into or out of the discharge port by rotating 90°, as shown in Figures 1 and 2. When the adapter component 132 drives the switch cover 120 to move into the discharge port, the switch cover 120 is in a horizontal state, and the switch cover 120 closes the discharge port, as shown in the solid line portion of Figures 1 and 2; when the adapter component 132 drives the switch cover 120 to move out of the discharge port, the switch cover 120 is in a vertical state, and the switch cover 120 opens the discharge port, as shown in the dotted line portion of Figures 1 and 2. Moreover, when the switch cover 120 opens the discharge port, the switch cover 120 will not block the discharge port, which is convenient for discharging.

[0055] In one embodiment, the adapter component 132 includes a first connecting arm 1321 and a second connecting arm 1322, one end of the first connecting arm 1321 is disposed at one end of the second connecting arm 1322, the other end of the second connecting arm 1322 is connected to the switch cover 120, the other end of the first connecting arm 1321 is rotatably disposed on the side of the reactor tank body 110, and the output end of the driving component 131 can also be rotatably connected to the first connecting arm 1321. That is, the adapter component 132 is a rotating arm. In this way, when the driving component 131 outputs movement, it can drive the first connecting arm 1321 to move along the reactor tank body 110, and then the first connecting arm 1321 drives the switch cover 120 to move through the second connecting arm 1322 to open or close the discharge port.

[0056] In one embodiment, the driving component 131 includes a cylinder, a hydraulic cylinder or a motor. Referring to FIG. 1 and FIG. 2 , illustratively, the driving component 131 is a cylinder, and the cylinder controls the adapter component 132 to drive the switch cover 120 to open or close the discharge port. Of course, in other embodiments of the present application, the driving component 131 may also be a hydraulic cylinder, a motor or other components capable of outputting movement to control the adapter component 132 to drive the switch cover 120 to open or close the discharge port.

[0057] Referring to FIG. 1 and FIG. 2 , in one embodiment, the driving mechanism 130 further includes a connecting component 133, which can rotatably connect the output end of the driving component 131 and the adapter component 132. The connecting component 133 can realize a reliable connection between the driving component 131 and the adapter component 132, so that the driving component 131 can reliably drive the adapter component 132 to drive the switch cover 120 to move, so as to open or close the discharge port. Optionally, the connecting component 133 at least includes a connecting shaft, etc.

[0058] Referring to Figures 1 and 2, in one embodiment, the peptide synthesizer reactor 100 further includes a pressure relief mechanism, which is disposed in the reactor tank 110 to relieve the pressure in the reaction chamber. After the material is reacted and produced in the reaction chamber of the reactor tank 110, there will be a certain pressure in the reaction chamber. If the switch cover 120 is opened directly, it will be laborious and even impossible to open.

[0059] To this end, the present application provides a pressure relief mechanism on the reactor tank 110, and then releases the pressure in the reaction chamber through the pressure relief mechanism. After the production of the peptide synthesizer reactor 100 is completed, the pressure in the reaction chamber is normal pressure after being processed by the pressure relief mechanism, and at this time, the switch cover 120 can be opened.

[0060] In one embodiment, the pressure relief mechanism includes a pressure relief pipe and a pressure relief valve. The pressure relief pipe is provided in the reactor tank body 110 and communicates with the reaction chamber. The pressure relief valve is provided in the pressure relief pipe. The pressure relief pipe is provided in the reactor tank body 110 and communicates with the reaction chamber. The pressure relief valve is provided in the pressure relief pipe. When the pressure relief valve is operated, the pressure relief valve performs pressure relief treatment on the reaction chamber through the communication between the pressure relief pipe and the reaction chamber.

[0061] Referring to FIG. 1 and FIG. 2 , in one embodiment, the reactor tank body 110 also has a feed port, which is located at the top of the reactor tank body 110. The peptide synthesizer reactor 100 also includes a stirring mechanism 160, which is sealed at the feed port and extends into the reaction chamber. The feed port is a feed channel of the reactor tank body 110, and is located at the top of the reactor tank body 110. The feed channel is connected to the reaction chamber, and the material enters the reaction chamber through the feed channel. Moreover, the stirring mechanism 160 is installed in the feed port and is sealed and connected to the reactor tank body 110 to avoid leakage. At the same time, the stirring mechanism 160 can also extend into the reaction chamber to stir the material in the reaction chamber to perform a production reaction.

[0062] Referring to FIG. 1 and FIG. 2 , in one embodiment, the reactor tank body 110 further includes a fixing flange 111, which is disposed at the bottom of the reactor tank body 110 and is located at the edge of the discharge port. The fixing flange 111 is disposed correspondingly to the switch cover 120, and the locking mechanism 140 can lock or unlock the switch cover 120 to the fixing flange 111. The fixing flange 111 is the connecting edge of the reactor tank body 110, and the fixing flange 111 is disposed at the edge of the discharge port and is disposed correspondingly to the switch cover 120. When the switch cover 120 closes the discharge port, the switch cover 120 fits the fixing flange 111 to seal the discharge port.

[0063] Moreover, the locking mechanism 140 can lock or unlock the switch cover 120 to the fixing flange 111. When the switch cover 120 closes the discharge port, the switch cover 120 can fit the fixing flange 111, and then the locking mechanism 140 is used to lock and connect the switch cover 120 and the fixing flange 111, so as to further fix the switch cover 120 to the fixing flange 111, thereby locking the switch cover 120 to the reactor tank body 110.

[0064] After the locking mechanism 140 is provided in the present application, the locking and unlocking of the switch cover 120 need to be performed twice, which is equivalent to double insurance, preventing the switch cover 120 from being opened by mistake, further improving safety, and at the same time, it will not affect the production efficiency and performance of the peptide synthesizer reactor 100. When the discharge port needs to be opened, the locking mechanism 140 is first controlled to unlock the switch cover 120 from the fixed flange 111, so that the locking mechanism 140 is disengaged from the switch cover 120, and then the switch cover 120 can be controlled to open the discharge port.

[0065] 1 and 2, in one embodiment, the locking mechanism 140 locks the switch cover 120 to the reactor tank body 110 automatically or manually. That is, the locking mechanism 140 can lock or unlock the switch cover 120 to the fixed flange 111 of the reactor tank body 110 by manual operation of the user, as shown in FIG1. ​​The locking mechanism 140 can also lock or unlock the switch cover 120 to the fixed flange 111 of the reactor tank body 110 by automatic control, as shown in FIG2.

[0066] Two possible implementations of the locking mechanism 140 are described below, illustrating that the locking mechanism 140 automatically or manually locks the switch cover 120 to the reactor tank body 110 . However, it should be emphasized that the specific structure of the locking mechanism 140 is not limited to the following embodiments.

[0067] 1 and 3, in the first embodiment of the present application, the locking mechanism 140 includes a first locking body 141, a second locking body 142 and a fastener 143. The first locking body 141 is provided on the switch cover 120, and the second locking body 142 is provided on the fixing flange 111 and is provided corresponding to the first locking body 141. The fastener 143 passes through the first locking body 141 and is installed in the second locking body 142. FIG3 is a partial enlarged view of the peptide synthesizer reactor 100 shown in FIG1 at A.

[0068] The first locking body 141 is arranged on the side of the switch cover 120 and is connected to the switch cover 120. The second locking body 142 is arranged on the side of the fixing flange 111 and is connected to the fixing flange 111. Moreover, the first locking body 141 and the second locking body 142 are correspondingly arranged in the vertical direction. After the fastener 143 passes through the first locking body 141 and is installed on the second locking body 142, the first locking body 141 and the second locking body 142 can be indirectly connected to avoid the first locking body 141 and the second locking body 142 from being separated, thereby locking the switch cover 120 to the fixing flange 111.

[0069] Moreover, when the fastener 143 is tightened, the fastener 143 can move toward the second locking body 142 through the first locking body 141, so that the switch cover 120 moves toward the fixing flange 111, so that the switch cover 120 is reliably fixed to the fixing flange 111. When the fastener 143 is loosened, the fastener 143 can drive the first locking body 141 to move in a direction away from the second locking body 142, so that the switch cover 120 gradually separates from the fixing flange 111.

[0070] In this embodiment, after the switch cover 120 closes the discharge port, the first locking body 141 is placed on the edge of the switch cover 120, the second locking body 142 is placed on the edge of the fixing flange 111, and then the fastener 143 is passed through the first locking body 141 and installed in the second locking body 142, and the fastener 143 is tightened, so that the switch cover 120 is reliably locked to the fixing flange 111. After the production is completed, the fastener 143 is loosened and removed from the first locking body 141 and the second locking body 142, and then the first locking body 141 is removed from the edge of the switch cover 120, and the second locking body 142 is removed from the edge of the fixing flange 111, and the switch cover 120 can be opened.

[0071] Optionally, the first locking body 141 and the second locking body 142 are locking blocks. Optionally, the first locking body 141 and the second locking body 142 can also be fixed plates, in which case the switch cover 120 and the fixing flange 111 can be clamped between the two fixed plates. Of course, in other embodiments of the present application, the first locking body 141 and the second locking body 142 can also be other structural forms that can achieve locking cooperation. Optionally, the fastener 143 is a threaded member such as a bolt.

[0072] Referring to Figures 1 and 3, in one embodiment, the first locking body 141 has a first mounting groove 1411, the second locking body 142 has a second mounting groove 1421, the end of the switch cover 120 is located in the first mounting groove 1411 and abuts the first mounting groove 1411, and the end of the fixing flange 111 is located in the second mounting groove 1421 and abuts the second mounting groove 1421.

[0073] The first locking body 141 has a first mounting groove 1411 which is recessed, and the first mounting groove 1411 is located on the surface of the first locking body 141 facing the switch cover 120, and the first locking body 141 is mounted to the switch cover 120 through the first mounting groove 1411. The second locking body 142 has a second mounting groove 1421 which is recessed, and the second mounting groove 1421 is located on the surface of the second locking body 142 facing the fixing flange 111, and the second locking body 142 is mounted to the switch cover 120 through the second mounting groove 1421.

[0074] Moreover, after the fastener 143 connects the first locking body 141 and the second locking body 142, the lower surface of the switch cover 120 abuts against the inner wall of the first mounting groove 1411, and the upper surface of the fixing flange 111 abuts against the inner wall of the second mounting groove 1421. After the fastener 143 is tightened, the switch cover 120 can be reliably locked to the fixing flange 111 through the limiting of the first mounting groove 1411 and the second mounting groove 1421.

[0075] Optionally, the first mounting groove 1411 vertically penetrates to the top of the first locking body 141, and the second mounting groove 1421 vertically penetrates to the bottom of the second locking body 142. After the first locking body 141 is mounted to the switch cover 120 through the first mounting groove 1411, and the second locking body 142 is mounted to the fixing flange 111 through the second mounting groove 1421, there is no obstruction between the edge of the switch cover 120 and the edge of the fixing flange 111, so that after tightening the fastener 143, the switch cover 120 can gradually approach the fixing flange 111 without being obstructed by the first locking body 141 and the second locking body 142, thereby ensuring the reliability of the locking of the switch cover 120.

[0076] 1 and 3, in one embodiment, one of the first locking body 141 and the second locking body 142 has a mounting cavity 1412, and the other of the first locking body 141 and the second locking body 142 is placed in the mounting cavity 1412. That is, one of the first locking body 141 and the second locking body 142 can be installed in the other to reduce the occupied space and ensure the reliability of the connection.

[0077] In this embodiment, the first locking body 141 has an installation cavity 1412, and the second locking body 142 is located in the installation cavity 1412. The fastener 143 passes through the first locking body 141 and extends into the installation cavity 1412, and connects the second locking body 142 in the installation cavity 1412. Moreover, after the second locking body 142 is installed in the installation cavity 1412, the second installation groove 1421 is opposite to and communicates with the first installation groove 1411.

[0078] Referring to Figures 1 and 3, in one embodiment, the first locking body 141 has a first fixing portion 1413, the switch cover 120 has a first matching portion 121 corresponding to the first fixing portion 1413, the first fixing portion 1413 is fixedly connected to the first matching portion 121, and the first fixing portion 1413 and the first matching portion 121 are a matching structure of a protrusion and a groove; and / or, the second locking body 142 has a second fixing portion 1422, the fixing flange 111 has a second matching portion 1111 corresponding to the second fixing portion 1422, the second fixing portion 1422 is fixedly connected to the second matching portion 1111, and the second fixing portion 1422 and the second matching portion 1111 are a matching structure of a protrusion and a groove.

[0079] When the first locking body 141 is installed to the edge of the switch cover 120 through the first mounting groove 1411, the first fixing portion 1413 of the first locking body 141 is clamped to the first matching portion 121 of the switch cover 120. After the second locking body 142 is installed to the mounting cavity 1412 and the second locking body 142 is installed to the edge of the switch cover 120 through the second mounting groove 1421, the second fixing portion 1422 of the second locking body 142 can be clamped to the second matching portion 1111 of the switch cover 120.

[0080] The clamping connection between the first fixing portion 1413 and the first matching portion 121 can prevent the first locking body 141 from being separated from the switch cover 120 in the radial direction of the switch cover 120, and the clamping connection between the second fixing portion 1422 and the second matching portion 1111 can prevent the second locking body 142 from being separated from the fixing flange 111 in the radial direction of the fixing flange 111. Moreover, after the fastener 143 is fastened to the first locking body 141 and the second locking body 142, the movement of the first locking body 141 and the second locking body 142 in the vertical direction can be restricted.

[0081] In this embodiment, the first fixing portion 1413 and the second fixing portion 1422 are protrusions, and the first matching portion 121 and the second matching portion 1111 are grooves. Of course, in other embodiments of the present application, the first fixing portion 1413 and the second fixing portion 1422 may be grooves, and the first matching portion 121 and the second matching portion 1111 may be protrusions.

[0082] In this way, through the cooperation of the fastener 143, the first fixing portion 1413 and the first matching portion 121, and the second fixing portion 1422 and the second matching portion 1111, the first locking body 141 and the second locking body 142 can be limited in the vertical direction and in the radial direction, preventing the first locking body 141 and the second locking body 142 from detaching from the switch cover 120 and the fixing flange 111, thereby ensuring that the switch cover 120 is reliably locked to the fixing flange 111.

[0083] In the peptide synthesizer reactor 100 of this embodiment, the locking mechanism 140 locks or unlocks the switch cover 120 to the fixed flange 111 by manual operation of the user. The locking mechanism 140 has a simple structure, is convenient for manual operation by the user, is practical and convenient, and can ensure that the switch cover 120 is reliably locked to the fixed flange 111 to prevent the switch cover 120 from being opened by mistake.

[0084] Referring to Fig. 2, Fig. 4 and Fig. 5, in the second embodiment of the present application, the locking mechanism 140 includes a locking driving member 144, a locking column 146 and a third locking body 145. The third locking body 145 is rotatably sleeved on the fixing flange 111 and covers the switch cover 120. The output end of the locking driving member 144 is connected to the third locking body 145. The locking column 146 is arranged at the edge of the switch cover 120 and radially protrudes. The third locking body 145 has a locking groove 1451. When the locking driving member 144 drives the third locking body 145 to rotate, the locking column 146 can move into or out of the locking groove 1451 to lock or unlock the switch cover 120 and the fixing flange 111. Fig. 4 is a partial enlarged view of the peptide synthesizer reactor 100 shown in Fig. 2 at B, and Fig. 5 is a bottom view of the peptide synthesizer reactor 100 shown in Fig. 2.

[0085] The locking driver 144 is the power source of the locking mechanism 140. The locking driver 144 controls the locking mechanism 140 to automatically lock or unlock the switch cover 120 to the fixed flange 111, thereby reducing the difficulty of manual operation and improving the operation efficiency. The locking driver 144 is arranged on the side of the bottom of the reactor tank 110. The third locking body 145 and the locking column 146 are the main parts for realizing the locking or unlocking of the switch cover 120 to the fixed flange 111.

[0086] The third locking body 145 is annularly arranged and rotatably sleeved on the fixing flange 111. The third locking body 145 is connected to the output end of the locking driver 144. The locking driver 144 can drive the third locking body 145 to rotate around the vertical axis of the reactor tank body 110. The locking column 146 is arranged on the outer peripheral surface of the switch cover 120, and the locking column 146 is radially protruding. The third locking body 145 has a locking groove 1451 that cooperates with the locking column 146.

[0087] In the initial state, the locking groove 1451 is aligned with the locking column 146, and the locking drive 144 drives the third locking body 145 to rotate in one direction (such as clockwise around the vertical axis). The third locking body 145 can drive the locking groove 1451 to slide along the locking column 146, so that the locking column 146 gradually moves into the locking groove 1451. At this time, the locking groove 1451 can limit the locking column 146 to prevent the locking column 146 from moving in the vertical direction, thereby preventing the switch cover 120 from opening the discharge port in the vertical direction, so that the locking mechanism 140 locks the switch cover 120 to the fixed flange 111.

[0088] When the discharge port needs to be opened, the locking driver 144 drives the third locking body 145 to rotate in another direction (e.g., counterclockwise around the vertical axis), and the third locking body 145 can drive the locking groove 1451 to slide along the locking column 146, so that the locking column 146 gradually slides out of the locking groove 1451. The locking driver 144 continues to drive the third locking body 145 to rotate until the locking column 146 moves out of the locking groove 1451. At this time, the locking mechanism 140 unlocks the switch cover 120 from the fixing flange 111, and the switch cover 120 can be opened.

[0089] Referring to Figures 2, 4 and 5, in one embodiment, the locking groove 1451 includes a first groove body 14511 and a second groove body 14512. The first groove body 14511 axially penetrates to the bottom of the third locking body 145, and the second groove body 14512 extends circumferentially and is connected to the first groove body 14511. When the third locking body 145 rotates, the first groove body 14511 and the second groove body 14512 can move along the locking column 146 to lock or unlock the switch cover 120 to the fixing flange 111.

[0090] The first groove 14511 passes through the bottom of the third locking body 145 in the vertical direction, and the second groove 14512 extends along the circumferential direction of the third locking body 145. The first groove 14511 is connected to the second groove 14512 and is generally L-shaped. When the locking mechanism 140 is required to lock the switch cover 120, the locking column 146 is aligned with the first groove 14511, and the locking drive 144 drives the third locking body 145 to rotate in one direction. The first groove 14511 can slide along the locking column 146. During the rotation process, the second groove 14512 can slide along the locking column 146 so that the locking column 146 moves into the locking groove 1451, thereby locking the switch cover 120 to the fixing flange 111 through the cooperation between the locking column 146 and the locking groove 1451 of the third locking body 145.

[0091] Conversely, when the switch cover 120 is unlocked from the fixed flange 111, the locking drive 144 drives the third locking body 145 to rotate in another direction, and the second groove body 14512 can slide along the locking column 146. During the rotation process, the first groove body 14511 slides along the locking column 146 to move the locking column 146 out of the locking groove 1451.

[0092] Referring to Fig. 2, Fig. 4 and Fig. 5, in one embodiment, the locking groove 1451 has a guide surface 14513, which is arranged obliquely, and is used to guide the locking groove 1451 to move along the locking column 146, so that the switch cover 120 is close to or away from the fixing flange 111, so as to lock or unlock the switch cover 120 to the fixing flange 111. The guide surface 14513 is an inclined surface, and after the guide surface 14513 is provided, when the locking driving member 144 drives the third locking body 145 to rotate, the guide surface 14513 can guide the guide column to move into the second groove body 14512, so that the locking column 146 is easily moved into the locking groove 1451.

[0093] Referring to Fig. 2, Fig. 4 and Fig. 5, in one embodiment, there are multiple locking columns 146, and the multiple locking columns 146 are evenly distributed along the circumference of the switch cover 120, and each locking column 146 corresponds to a locking groove 1451. That is, the present application uses the cooperation of multiple locking columns 146 and multiple locking grooves 1451 to reliably lock the switch cover 120 to the fixing flange 111, and the locking columns 146 and the locking grooves 1451 are arranged one by one, and each locking column 146 can be moved into or out of the corresponding locking groove 1451, so as to ensure that the switch cover 120 is reliably locked.

[0094] Referring to Fig. 2, Fig. 4 and Fig. 5, in one embodiment, the locking mechanism 140 further comprises a mounting seat 147, the mounting seat 147 is arranged on the reactor tank body 110, the locking driver 144 is arranged on the mounting seat 147, the output end of the locking driver 144 is connected to the third locking body 145, and the locking driver 144 is a cylinder, a hydraulic cylinder or a motor. The mounting seat 147 is a mounting component of the locking driver 144 to fix the locking driver 144 to the side of the reactor tank body 110.

[0095] Optionally, the mounting seat 147 is plate-shaped or block-shaped, and is fixed to the side of the reactor tank body 110 by a screw. Of course, in other embodiments of the present application, the mounting seat 147 can also be a mounting bracket, etc. Referring to Figures 2, 4 and 5, illustratively, the locking driver 144 is a cylinder, and the locking and unlocking of the switch cover 120 are achieved by controlling the cooperation between the third locking body 145 and the locking column 146 by the cylinder. Of course, in other embodiments of the present application, the locking driver 144 can also be a motor, a hydraulic cylinder or other components that can drive the third locking body 145 to rotate.

[0096] In the peptide synthesizer reactor 100 of the present embodiment, the locking mechanism 140 locks or unlocks the switch cover 120 to the fixed flange 111 by automatic operation. The locking mechanism 140 has a simple structure and does not require manual operation by the user, thereby reducing the difficulty of operation and the potential safety hazards caused by manual operation. At the same time, the operation time is reduced, the auxiliary time for equipment operation is increased, the production efficiency is improved, and the system is practical and convenient. In addition, the switch cover 120 can be reliably locked to the fixed flange 111 to prevent the switch cover 120 from being opened by mistake.

[0097] Before the production of the peptide synthesizer reactor 100 of the present application begins, the driving mechanism 130 drives the switch cover 120 to close the discharge port, and the locking mechanism 140 is used to lock and connect the switch cover 120 and the reactor tank body 110, so as to reliably fix the switch cover 120 to the reactor tank body 110. Subsequently, the material enters the reaction chamber of the reactor tank body 110 through the feed port, and the production operation (feeding, stirring, reaction, filtering, cleaning) is carried out. After the production is completed, the pressure in the reaction chamber is relieved by the pressure relief mechanism. When the pressure in the reaction chamber is at normal pressure, the locking mechanism 140 is disengaged from the switch cover 120 to unlock the switch cover 120 from the reactor tank body 110, and then the switch cover 120 can be controlled to open the discharge port, and the discharge operation can be carried out through the discharge port. After the discharge is completed, the reactor tank body 110 and the switch cover 120 are cleaned. After the cleaning is completed, the peptide synthesizer reactor 100 enters the standby state.

[0098] The peptide synthesizer reactor 100 of the present application is provided with a locking mechanism 140 on the outside of the reactor tank body 110, and the locking mechanism 140 is used to unlock or lock the switch cover 120 and the reactor tank body 110. When the switch cover 120 is closed, the locking mechanism 140 can lock and connect the switch cover 120 and the reactor tank body 110, ensuring that the switch cover 120 can effectively close the discharge port, thereby ensuring that the peptide synthesizer reactor 100 can normally carry out reaction production. After the production is completed, the locking mechanism 140 unlocks the switch cover 120, and the driving mechanism 130 can drive the switch cover 120 to open for operations such as unloading. The peptide synthesizer reactor 100 realizes reliable locking between the switch cover 120 and the reactor tank body 110 through the locking mechanism 140, so as to avoid the switch cover 120 being opened by mistake during the reaction production, improve safety, and ensure the use performance and production efficiency of the peptide synthesizer reactor 100. At the same time, the peptide synthesizer reactor 100 has a simple structure, which is convenient and practical.

[0099] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0100] The above-described embodiments only express several implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be construed as limiting the scope of the patent application. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the protection scope of the patent application shall be subject to the attached claims.

Claims

1. A peptide synthesizer reactor, characterized in that: include: A reactor tank body, wherein the reactor tank body has a reaction chamber and a discharge port, wherein the discharge port is arranged at the bottom of the reactor tank body and communicates with the reaction chamber; A switch cover is located at the bottom of the outer side of the reactor tank body and can open or close the discharge port; A driving mechanism is arranged on the outside of the reactor tank body and connected to the switch cover, wherein the driving mechanism drives the switch cover to move relative to the reactor tank body to open or close the discharge port; as well as The locking mechanism is arranged on the outside of the reactor tank body, and the locking mechanism can lock or unlock the switch cover and the reactor tank body. After the switch cover closes the discharge port, the locking mechanism can lock the switch cover to the reactor tank body.

2. The peptide synthesizer reactor according to claim 1, characterized in that: The reactor tank body further comprises a fixing flange, which is arranged at the bottom of the reactor tank body and located at the edge of the discharge port; The fixing flange is arranged corresponding to the switch cover, and the locking mechanism can lock or unlock the switch cover to the fixing flange.

3. The peptide synthesizer reactor according to claim 2, characterized in that: The locking mechanism comprises a first locking body, a second locking body and a fastener, wherein the first locking body is arranged on the switch cover, and the second locking body is arranged on the fixing flange and is arranged corresponding to the first locking body; The fastener passes through the first locking body and is installed in the second locking body.

4. The peptide synthesizer reactor according to claim 3, characterized in that: One of the first locking body and the second locking body has a mounting cavity, and the other of the first locking body and the second locking body is placed in the mounting cavity; And / or, the first locking body has a first mounting groove, the second locking body has a second mounting groove, the end of the switch cover is located in the first mounting groove and abuts the first mounting groove, and the end of the fixing flange is located in the second mounting groove and abuts the second mounting groove.

5. The peptide synthesizer reactor according to claim 3, characterized in that: The first locking body has a first fixing portion, the switch cover has a first matching portion corresponding to the first fixing portion, the first fixing portion and the first matching portion are fixedly connected, and the first fixing portion and the first matching portion are a matching structure of a protrusion and a groove; And / or, the second locking body has a second fixing portion, the fixing flange has a second matching portion corresponding to the second fixing portion, the second fixing portion and the second matching portion are fixedly connected, and the second fixing portion and the second matching portion are a matching structure of a protrusion and a groove.

6. The peptide synthesizer reactor according to claim 2, characterized in that: The locking mechanism comprises a locking drive, a locking column and a third locking body, wherein the third locking body is rotatably sleeved on the fixing flange and covers the switch cover, and the output end of the locking drive is connected to the third locking body; The locking column is arranged on the edge of the switch cover and protrudes radially. The third locking body has a locking groove. When the locking drive drives the third locking body to rotate, the locking column can move into or out of the locking groove to lock or unlock the switch cover and the fixing flange.

7. The peptide synthesizer reactor according to claim 6, characterized in that: The locking groove includes a first groove body and a second groove body, the first groove body axially penetrates to the bottom of the third locking body, the second groove body extends circumferentially and communicates with the first groove body, and when the third locking body rotates, the first groove body and the second groove body can move along the locking column to lock or unlock the switch cover to the fixing flange; And / or, the locking groove has a guide surface, which is arranged at an angle, and the guide surface is used to guide the locking groove to move along the locking column, so that the switch cover is close to or away from the fixing flange, so as to lock or unlock the switch cover to the fixing flange.

8. The peptide synthesizer reactor according to claim 6, characterized in that: There are multiple locking columns, and the multiple locking columns are evenly distributed along the circumference of the switch cover, and each locking column corresponds to one locking groove; And / or, the locking mechanism also includes a mounting seat, the mounting seat is arranged on the reactor tank body, the locking drive is arranged on the mounting seat, the output end of the locking drive is connected to the third locking body, and the locking drive is a cylinder, a hydraulic cylinder or a motor.

9. The peptide synthesizer reactor according to any one of claims 1 to 8, characterized in that: The driving mechanism includes a driving component and a switching component, wherein the driving component is arranged on the outside of the reactor tank body, the switching component is movably arranged on the bottom of the reactor tank body, and the switching component is also connected to the switch cover; The output end of the driving component is connected to one end of the adapter component, and the driving component can drive the adapter component to move relative to the reactor tank body, so that the adapter component drives the switch cover to open or close the discharge port.

10. The peptide synthesizer reactor according to any one of claims 1 to 8, characterized in that: The peptide synthesizer reactor also includes a pressure relief mechanism, which includes a pressure relief pipe and a pressure relief valve. The pressure relief pipe is arranged on the reactor tank body and communicates with the reaction chamber. The pressure relief valve is arranged on the pressure relief pipe. And / or, the reactor tank body further comprises a feed inlet, the feed inlet is located at the top of the reactor tank body, and the peptide synthesizer reactor further comprises a stirring mechanism, the stirring mechanism is sealed at the feed inlet and extends into the reaction chamber.

Images