Health-care gel capable of activating blood and expelling toxins and preparation method of health-care gel

Abstract

The invention provides a blood-activating and toxin-expelling health-care gel and a preparation method thereof, and relates to the technical field of blood-activating medicines, the blood-activating and toxin-expelling health-care gel comprises a first substrate and a second substrate, the first substrate comprises the following components in parts by weight: 100-300 parts of caulis spatholobi, 100-300 parts of radix scrophulariae, 50-300 parts of honeysuckle, 50-300 parts of lycopodium clavatum, 50-300 parts of saffron and 25-150 parts of rhizoma smilacis glabrae. Traditional Chinese medicinal materials including caulis spatholobi, radix scrophulariae, honeysuckle and stigma croci in the first matrix have the effects of promoting blood circulation to remove blood stasis, clearing away heat and toxic materials and resisting inflammation, active ingredients in the traditional Chinese medicinal materials are effectively extracted through multiple times of decoction and concentration extraction, and it is ensured that the efficacy of the medicine is fully exerted. The water quantity control in the decoction process can ensure that all the components are completely dissolved out, and meanwhile, decoction solutions are combined after three times of decoction, so that the concentration of the extract is more uniform and stable.

Description

Technical Field

[0001] The invention relates to the technical field of blood-activating medicines, and in particular to a blood-activating and detoxifying health-care gel and a preparation method thereof. Background Art

[0002] The technical field of blood-activating drugs mainly involves health products that regulate the body by improving blood circulation, promoting blood flow, and eliminating blood stasis. Drugs or health products in this field are usually used to treat or prevent blood stasis symptoms, such as congestion, swelling and pain, subcutaneous hemorrhage, and local blood flow stagnation. In addition, blood-activating drugs are often used in combination with detoxification effects to help remove toxins accumulated in the body, promote metabolism, and enhance the body's self-repair function.

[0003] The existing technology lacks precise process control when extracting active ingredients of traditional Chinese medicine, resulting in insufficient dissolution of active ingredients of medicinal materials, affecting the stability and efficacy of the final product. In addition, the extraction process of traditional Chinese medicine is prone to uneven concentration, which weakens the sustainability of the drug's efficacy. In addition, the existing technology has a single formula design and lacks optimization of product structure and user experience, resulting in the gel texture being not delicate enough, poor skin absorption, and unclear moisturizing and repairing effects. Summary of the invention

[0004] The purpose of the present invention is to solve the shortcomings of the prior art and to propose a blood-activating and detoxifying health-care gel and a preparation method thereof.

[0005] In order to achieve the above object, the present invention adopts the following technical scheme: a blood-activating and detoxifying health gel, the blood-activating and detoxifying health gel comprises a first matrix and a second matrix, the first matrix comprises the following components in parts by weight:

[0006] 100-300 parts of Millettia reticulata, 100-300 parts of Scrophularia ningpoensis, 50-300 parts of honeysuckle, 50-300 parts of Lycopodiella cuneata, 50-300 parts of saffron, 25-150 parts of Smilax glabra, 25-150 parts of Burdock seeds, 25-150 parts of Ginkgo biloba leaves, 25-125 parts of Aloe vera, 25-150 parts of Frankincense, 10-150 parts of seaweed, 20-150 parts of Evening Primrose root, 5-150 parts of Konjac, 5-120 parts of Blueberry, 10-100 parts of Rose, 5-15 parts of Ganoderma lucidum;

[0007] The second matrix comprises the following components in parts by weight:

[0008] Thickener 1.2-3 parts, humectant 3-6 parts, glycerin 3-7 parts, pH adjuster 1-2 parts, antioxidant 0.01-0.5 parts, plant enzyme 0.01-0.5 parts, preservative 0.01-0.5 parts, collagen peptide 0.001-0.01 parts, sodium hyaluronate 0.1-0.5 parts, allantoin 0.01-0.07 parts, purified water 40-60 parts.

[0009] Preferably, the thickener is any one of carbomer, xanthan gum, sodium carboxymethyl cellulose, guar gum and sodium alginate.

[0010] Preferably, the moisturizing agent is any one of propylene glycol, butylene glycol and polyethylene glycol.

[0011] Preferably, the pH adjuster is any one of triethanolamine, sodium hydroxide, potassium hydroxide, diethanolamine and boric acid.

[0012] Preferably, the antioxidant is any one of yeast and lactic acid bacteria fermentation products.

[0013] Preferably, the preservative is any one of phenoxyethanol, sodium benzoate, ethylhexylglycerin, hexylene glycol and methylisothiazolinone.

[0014] The present invention provides a method for preparing a blood-activating and detoxifying health-care gel, comprising the following steps:

[0015] S1, decocting the first matrix medicinal material, adding Millettia spatholobi, Scrophularia ningpoensis, Honeysuckle, Lycopodiella cuneata, Crocus, Smilax glabra, Burdock fruit, Ginkgo biloba, Aloe vera, Frankincense, Seaweed, Evening primrose root, Konjac, Blueberry, Rose and Ganoderma lucidum to a reactor, controlling the proportion of water to 5 times, 2 times and 1.5 times the weight of the medicinal materials, decocting three times, maintaining the heating temperature between 80-100° C., and the decoction time for each time is 30 minutes. After each decoction, filtering the medicinal liquid, controlling the filter pore size between 0.5-1 mm, combining the three decoctions and continuing to heat and concentrate, concentrating to 2-3 times the amount of the crude drug, maintaining the temperature between 70-90° C. during the concentration process, and obtaining the decoction supernatant;

[0016] S2, aqueous phase preparation, introducing the decoction supernatant into a stirring device, turning on the stirring device, controlling the speed between 200-300 RPM, adding purified water, maintaining the temperature between 50-60° C. during stirring, allowing the decoction and water to be evenly mixed, and controlling the stirring time to be 5-10 minutes. After the stirring is completed, using a temperature sensor to detect the temperature of the solution to ensure that the temperature is evenly maintained within the set range, thereby obtaining an aqueous phase solution;

[0017] S3, oil phase preparation, the aqueous phase solution is allowed to stand for 10-20 minutes, and then glycerin, antioxidant, preservative, plant enzyme, moisturizer and pH adjuster are added to the reaction kettle in order by weight, the temperature of the oil phase mixture is maintained between 60-80° C., the speed of the stirring device is set to 200-400 RPM, and the stirring time is 10-20 minutes to obtain an oil phase solution;

[0018] S4, two-phase emulsification treatment, gradually adding the aqueous phase solution to the oil phase solution, using a quantitative pump during the addition, the pumping speed is controlled at 1-5L / min, the aqueous phase and the oil phase are fully contacted, the speed of the stirring device is set to 230-500RPM, the stirring temperature is maintained between 60-70°C, the emulsification time is controlled at 15-30 minutes, and the diameter of the emulsified particles is controlled at 1-10 microns to obtain an emulsified solution;

[0019] S5, ultrasonic pretreatment, performing ultrasonic treatment on the emulsified solution, setting the ultrasonic frequency to 20-40 kHz, and the treatment time to 5-10 minutes to obtain an ultrasonically treated emulsified solution;

[0020] S6, preparation of the second matrix, adding the thickener, collagen peptide, sodium hyaluronate and allantoin by weight into the stirrer, the order of adding the easily soluble components first, and then the insoluble components, the stirring speed is controlled at 200-400RPM, the stirring time is 5-10 minutes, and the temperature is maintained between 25-30°C to obtain the second matrix solution;

[0021] S7, ultrasonic homogenization treatment, gradually adding the ultrasonic treatment emulsified solution into the second matrix solution, using an ultrasonic homogenization device, the device frequency is set between 20-30kHz, the homogenization treatment time is set to 10-20 minutes, so that each component is evenly dispersed in the matrix solution to obtain a homogenous emulsified solution,

[0022] S8, bubble atomization preparation, stirring the homogeneous emulsified solution, and then using a high-pressure bubble generating device, the air pressure of the bubble generating device is set to a range of 500-1000 Pa, and the bubbles are injected into the agitator, the gas injection time is maintained at 10-15 minutes, and the bubble diameter is controlled between 20-100 microns to obtain a bubble atomized solution;

[0023] S9, bubble atomization condensation treatment, performing condensation treatment in the bubble atomization solution, using a condensation device to reduce the temperature of the solution to between 10-20° C., and controlling the condensation time to between 5-10 minutes to obtain a condensed emulsified solution;

[0024] S10, micron bubble injection, using a micron bubble generating device for the condensed emulsified solution, the air pressure of the bubble generating device is maintained between 200-500 Pa, the bubble diameter is controlled within the range of 1-10 microns, and the injection time is set to 5-10 minutes to obtain a micron bubble emulsified solution;

[0025] S11, electrostatic spray treatment, applying electrostatic spray technology to the micron bubble emulsified solution, spraying charged particles uniformly into the solution through an electrostatic spray device, setting the electrostatic voltage to 20-50 kV, and the treatment time to 5-10 minutes. The diameter of the charged particles is controlled to be between 1-5 microns, and the particles are uniformly distributed on the surface of the solution through the electrostatic field, and a multilayer structure is formed in the solution. After the spray treatment is completed, a multilayer emulsified solution is obtained;

[0026] S12, multilayer structure formation, the multilayer emulsified solution is allowed to stand at a temperature between 25-35° C. for 30-60 minutes. During the standing process, the formation state of the multilayer structure is checked by a microscopic monitoring device to verify that each layer structure is uniform and stable. After the standing is completed, a stable multilayer structure solution is obtained;

[0027] S13, homogenous mixing, adding the remaining part of the second matrix to the stable multilayer structure solution, stirring using a homogenizing device, maintaining the stirring speed between 300-500 RPM, and stirring for 15-30 minutes to obtain a homogenous paste.

[0028] S14, a paste-forming step, heating the homogenized paste, maintaining the heating temperature between 50-60° C. for 2-3 hours, filtering the paste using a filtering device after heating, controlling the filter pore size between 0.5-1 mm, and naturally cooling the filtered paste to room temperature to obtain a cooled paste;

[0029] S15, finished product packaging, the cooled paste is packaged, the packaging container is heated by a water bath, the water bath temperature is controlled between 55-60° C., and the paste is sealed after the packaging is completed to obtain a finished product of a blood-activating and detoxifying health gel;

[0030] S16, finished product storage, placing the finished product of the blood-activating and detoxifying health-care gel in a constant temperature storage device.

[0031] Preferably, in step S16, the storage temperature of the constant temperature storage device is set between 15-25°C, and the humidity is maintained between 40-60%.

[0032] 1. Compared with the prior art, the Chinese medicinal materials of Millettia spatholobi, Scrophularia ningpoensis, Flos Lonicerae, and Crocus chinensis in the first matrix of the present invention have the effects of promoting blood circulation and removing blood stasis, clearing away heat and detoxifying, and anti-inflammatory. Through multiple decoctions and concentrated extractions, the active ingredients in the Chinese medicinal materials are effectively extracted, ensuring that the efficacy of the medicine is fully exerted. The water volume control during the decoction process can ensure the complete dissolution of each component. At the same time, the decoction is combined after three decoctions, so that the concentration of the extract is more uniform and stable. Secondly, the thickener and humectant in the second matrix can form a stable paste structure in the gel, improve the texture of the product, make the product easier to absorb by the skin, and have good moisturizing and repairing functions. The antioxidants and plant enzymes in the formula further enhance the anti-aging effect of the gel by resisting oxidative stress and delaying skin aging.

[0033] 2. Compared with the prior art, the present invention uses a two-phase emulsification technology to fully emulsify the water phase and the oil phase, so that the active ingredients are more evenly dispersed in the water-oil mixed matrix, thereby enhancing the absorbency and stability of the product. Secondly, the ultrasonic homogenization technology further ensures the particle refinement and uniform distribution of the active ingredients, avoids the agglomeration of the ingredients, and improves the texture and absorption effect of the product. The bubble atomization condensation technology uses tiny droplets generated by high-pressure bubbles to quickly form a uniform gel structure during the cooling process, so that the gel is more delicate and easy to extend when applied. The micron bubble injection technology increases the skin permeability of the product by introducing tiny bubbles, which helps the deeper absorption of the active ingredients and improves the efficacy and use effect of the product. The electrostatic spray technology forms a multi-layer structure through the uniform spraying of charged particles, ensures the layer-by-layer release of the active ingredients, prolongs the continuous effect of the product, and realizes the high efficiency and accuracy of raw material processing, which not only improves the stability of the product, but also significantly improves the use experience and efficacy, ensuring that the blood circulation and detoxification health gel has superior performance in texture, absorbency and active substance transfer.

[0034] The technical solution of the present invention is further described in detail below through the accompanying drawings and embodiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0036] Figure 1 The present invention provides a preparation process diagram of a method for preparing a blood-activating and detoxifying health-care gel. DETAILED DESCRIPTION

[0037] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0038] Example 1, a blood-activating and detoxifying health gel, the blood-activating and detoxifying health gel comprises a first matrix and a second matrix, the first matrix comprises the following components in parts by weight:

[0039] 100 parts of Millettia reticulata, 300 parts of Scrophularia ningpoensis, 50 parts of Honeysuckle, 300 parts of Lycopodiella ciliata, 300 parts of Crocus saffron, 25 parts of Smilax glabra, 150 parts of Burdock fruit, 150 parts of Ginkgo biloba leaves, 25 parts of Aloe vera, 150 parts of Frankincense, 150 parts of Seaweed, 150 parts of Evening Primrose Root, 150 parts of Konjac, 120 parts of Blueberry, 100 parts of Rose, 15 parts of Ganoderma lucidum;

[0040] The second matrix comprises the following components by weight:

[0041] 3 parts of thickener, 6 parts of moisturizer, 7 parts of glycerin, 2 parts of pH adjuster, 0.5 parts of antioxidant, 0.5 parts of plant enzyme, 0.5 parts of preservative, 0.002 parts of collagen peptide, 0.5 parts of sodium hyaluronate, 0.07 parts of allantoin, 60 parts of purified water.

[0042] In this embodiment, the thickener is carbomer.

[0043] In this embodiment, the moisturizing agent is propylene glycol.

[0044] In this embodiment, the pH adjuster is triethanolamine.

[0045] In this embodiment, the antioxidant is yeast.

[0046] In this embodiment, the preservative is phenoxyethanol.

[0047] A method for preparing a blood-activating and detoxifying health gel comprises the following steps:

[0048] S1, decocting the first matrix medicinal material, adding Millettia spatholobi, Scrophularia ningpoensis, Honeysuckle, Lycopodiella cuneata, Crocus, Smilax glabra, Burdock fruit, Ginkgo biloba, Aloe vera, Frankincense, Seaweed, Evening primrose root, Konjac, Blueberry, Rose and Ganoderma lucidum into a reactor, controlling the proportion of water to 5 times, 2 times and 1.5 times the weight of the medicinal materials, decocting three times, maintaining the heating temperature at 100°C, and the decoction time for each time is 30 minutes. After each decoction, filtering the medicinal liquid, controlling the filter pore size at 1mm, combining the three decoctions and continuing to heat and concentrate, concentrating to 3 times the amount of the crude drug, maintaining the temperature at 90°C during the concentration process, and obtaining the decoction supernatant;

[0049] S2, aqueous phase preparation, introducing the decoction supernatant into the stirring device, turning on the stirring device, controlling the speed at 300RPM, adding purified water, maintaining the temperature at 60°C during stirring, allowing the decoction and water to be evenly mixed, and controlling the stirring time to 10 minutes. After the stirring is completed, using a temperature sensor to detect the temperature of the solution to ensure that the temperature is evenly maintained within the set range, thereby obtaining an aqueous phase solution;

[0050] S3, oil phase preparation, the aqueous phase solution is allowed to stand for 20 minutes, and then glycerin, antioxidant, preservative, plant enzyme, moisturizer and pH adjuster are added to the reactor in order by weight, the temperature of the oil phase mixture is maintained at 80° C., the speed of the stirring device is set to 400 RPM, and the stirring time is 20 minutes to obtain an oil phase solution;

[0051] S4, two-phase emulsification treatment, gradually adding the aqueous phase solution to the oil phase solution, using a quantitative pump during the addition, the pumping speed is controlled at 1L / min, the aqueous phase and the oil phase are fully contacted, the speed of the stirring device is set to 500RPM, the stirring temperature is maintained at 70°C, the emulsification time is controlled at 30 minutes, the emulsified particle diameter is controlled at 10 microns, and an emulsified solution is obtained;

[0052] S5, ultrasonic pretreatment, performing ultrasonic treatment on the emulsified solution, the ultrasonic frequency is set to 40 kHz, the treatment time is 10 minutes, and an ultrasonically treated emulsified solution is obtained;

[0053] S6, preparation of the second matrix, adding the thickener, collagen peptide, sodium hyaluronate and allantoin by weight into the stirrer, and adding the easily soluble components first, and then adding the insoluble components, the stirring speed is controlled at 400 RPM, the stirring time is 10 minutes, and the temperature is maintained at 30° C. to obtain the second matrix solution;

[0054] S7, ultrasonic homogenization treatment, gradually adding ultrasonic treatment emulsified solution into the second matrix solution, using ultrasonic homogenization equipment, the equipment frequency is set at 30kHz, the homogenization treatment time is set to 20 minutes, so that each component is evenly dispersed in the matrix solution to obtain a homogenous emulsified solution,

[0055] S8, bubble atomization preparation, stirring the homogenized emulsified solution, and then using a high-pressure bubble generating device, the air pressure of the bubble generating device is set to within 1000 Pa, and the bubbles are injected into the agitator, the gas injection time is maintained at 15 minutes, and the bubble diameter is controlled at 100 microns to obtain a bubble atomized solution;

[0056] S9, bubble atomization condensation treatment, performing condensation treatment in the bubble atomization solution, using a condensation device to reduce the temperature of the solution to 20° C., and controlling the condensation time to 10 minutes to obtain a condensed emulsified solution;

[0057] S10, micron bubble injection, using a micron bubble generator for the condensed emulsified solution, the air pressure of the bubble generator is maintained at 200 Pa, the bubble diameter is controlled within the range of 1 micron, and the injection time is set to 5 minutes to obtain a micron bubble emulsified solution;

[0058] S11, electrostatic spray treatment, applying electrostatic spray technology in the micron bubble emulsified solution, spraying charged particles evenly into the solution through the electrostatic spray equipment, the electrostatic voltage is set to 20 kV, the treatment time is 5 minutes, the diameter of the charged particles is controlled to 1 micron, the particles are evenly distributed on the surface of the solution through the electrostatic field, and a multi-layer structure is formed in the solution. After the spray treatment is completed, a multi-layer emulsified solution is obtained;

[0059] S12, multilayer structure formation, the multilayer emulsified solution is allowed to stand at a temperature of 25° C. for 30 minutes. During the standing process, the formation state of the multilayer structure is checked by a microscopic monitoring device to verify that each layer is uniform and stable. After the standing is completed, a stable multilayer structure solution is obtained;

[0060] S13, homogenizing and mixing, adding the remaining part of the second matrix to the stable multilayer structure solution, stirring using a homogenizing device, maintaining the stirring speed at 300 RPM, and stirring for 15 minutes to obtain a homogenous paste.

[0061] S14, a paste-forming process, heating the homogenized paste, maintaining the heating temperature at 50° C. for 2 hours, filtering the paste using a filtering device after heating, and controlling the filter pore size at 1 mm. The filtered paste needs to be naturally cooled to room temperature to obtain a cooled paste;

[0062] S15, finished product packaging, the cooled paste is packaged, the packaging container is heated by a water bath, the water bath temperature is controlled at 55° C., and the paste is sealed after the packaging is completed to obtain the finished product of the 26th Imperial Prescription Blood Activating and Detoxifying Health Gel;

[0063] S16, finished product storage, placing the finished product of the 26 Imperial Prescriptions Blood Activating and Detoxifying Health Gel in a constant temperature storage device.

[0064] In this embodiment, in step S16, the storage temperature of the constant temperature storage device is set at 25° C. and the humidity is maintained at 60%.

[0065] Example 2, a blood-activating and detoxifying health gel, the blood-activating and detoxifying health gel comprises a first matrix and a second matrix, the first matrix comprises the following components in parts by weight:

[0066] 100 parts of Millettia reticulata, 100 parts of Scrophularia ningpoensis, 50 parts of Honeysuckle, 50 parts of Lycopodiella cuneata, 50 parts of Crocus saffron, 25 parts of Smilax glabra, 25 parts of Burdock fruit, 25 parts of Ginkgo biloba leaves, 25 parts of Aloe vera, 25 parts of Frankincense, 10 parts of Seaweed, 20 parts of Evening Primrose root, 5 parts of Konjac, 5 parts of Blueberry, 10 parts of Rose, 5 parts of Ganoderma lucidum;

[0067] The second matrix comprises the following components by weight:

[0068] 1.2 parts of thickener, 3 parts of moisturizer, 3 parts of glycerin, 1 part of pH adjuster, 0.01 parts of antioxidant, 0.01 parts of plant enzyme, 0.01 parts of preservative, 0.001 parts of collagen peptide, 0.1 parts of sodium hyaluronate, 0.01 parts of allantoin, 40 parts of purified water.

[0069] In this embodiment, the thickener is xanthan gum.

[0070] In this embodiment, the moisturizing agent is butylene glycol.

[0071] In this embodiment, the pH adjuster is sodium hydroxide.

[0072] In this embodiment, the antioxidant is yeast.

[0073] In this embodiment, the preservative is phenoxyethanol.

[0074] A method for preparing a blood-activating and detoxifying health gel comprises the following steps:

[0075] S1, decocting the first matrix medicinal material, adding Millettia spatholobi, Scrophularia ningpoensis, Honeysuckle, Lycopodiella cuneata, Crocus, Smilax glabra, Burdock fruit, Ginkgo biloba, Aloe vera, Frankincense, Seaweed, Evening primrose root, Konjac, Blueberry, Rose and Ganoderma lucidum into a reactor, controlling the proportion of water to 5 times, 2 times and 1.5 times the weight of the medicinal materials, decocting three times, maintaining the heating temperature at 100°C, and the decoction time for each time is 30 minutes. After each decoction, filtering the medicinal liquid, controlling the filter pore size at 1mm, combining the three decoctions and continuing to heat and concentrate, concentrating to 3 times the amount of the crude drug, maintaining the temperature at 90°C during the concentration process, and obtaining the decoction supernatant;

[0076] S2, aqueous phase preparation, introducing the decoction supernatant into the stirring device, turning on the stirring device, controlling the speed at 300RPM, adding purified water, maintaining the temperature at 60°C during stirring, allowing the decoction and water to be evenly mixed, and controlling the stirring time to 10 minutes. After the stirring is completed, using a temperature sensor to detect the temperature of the solution to ensure that the temperature is evenly maintained within the set range, thereby obtaining an aqueous phase solution;

[0077] S3, oil phase preparation, the aqueous phase solution is allowed to stand for 20 minutes, and then glycerin, antioxidant, preservative, plant enzyme, moisturizer and pH adjuster are added to the reactor in order by weight, the temperature of the oil phase mixture is maintained at 80° C., the speed of the stirring device is set to 400 RPM, and the stirring time is 20 minutes to obtain an oil phase solution;

[0078] S4, two-phase emulsification treatment, gradually adding the aqueous phase solution to the oil phase solution, using a quantitative pump during the addition, the pumping speed is controlled at 1L / min, so that the aqueous phase and the oil phase are fully in contact, the speed of the stirring device is set to 230RPM, the stirring temperature is maintained at 60°C, the emulsification time is controlled at 15 minutes, and the diameter of the emulsified particles is controlled at 1 micron to obtain an emulsified solution;

[0079] S5, ultrasonic pretreatment, performing ultrasonic treatment on the emulsified solution, the ultrasonic frequency is set to 20 kHz, the treatment time is 5 minutes, and an ultrasonically treated emulsified solution is obtained;

[0080] S6, preparation of the second matrix, adding the thickener, collagen peptide, sodium hyaluronate and allantoin by weight into the stirrer, and adding the easily soluble components first, and then adding the insoluble components, the stirring speed is controlled at 200 RPM, the stirring time is 5 minutes, and the temperature is maintained at 25° C. to obtain the second matrix solution;

[0081] S7, ultrasonic homogenization treatment, gradually adding ultrasonic treatment emulsified solution into the second matrix solution, using ultrasonic homogenization equipment, the equipment frequency is set at 20kHz, the homogenization time is set to 10 minutes, so that each component is evenly dispersed in the matrix solution to obtain a homogenous emulsified solution,

[0082] S8, bubble atomization preparation, stirring the homogenized emulsified solution, and then using a high-pressure bubble generating device, the air pressure of the bubble generating device is set to within 500 Pa, and the bubbles are injected into the agitator, the gas injection time is maintained at 10 minutes, and the bubble diameter is controlled at 20 microns to obtain a bubble atomized solution;

[0083] S9, bubble atomization condensation treatment, performing condensation treatment in the bubble atomization solution, using a condensation device to reduce the temperature of the solution to 10° C., and controlling the condensation time to 5 minutes to obtain a condensed emulsified solution;

[0084] S10, micron bubble injection, using a micron bubble generator for the condensed emulsified solution, the air pressure of the bubble generator is maintained at 200 Pa, the bubble diameter is controlled within the range of 1 micron, and the injection time is set to 5 minutes to obtain a micron bubble emulsified solution;

[0085] S11, electrostatic spray treatment, applying electrostatic spray technology in the micron bubble emulsified solution, spraying charged particles evenly into the solution through the electrostatic spray equipment, the electrostatic voltage is set to 20 kV, the treatment time is 5 minutes, the diameter of the charged particles is controlled to 1 micron, the particles are evenly distributed on the surface of the solution through the electrostatic field, and a multi-layer structure is formed in the solution. After the spray treatment is completed, a multi-layer emulsified solution is obtained;

[0086] S12, multilayer structure formation, the multilayer emulsified solution is allowed to stand at a temperature of 25° C. for 30 minutes. During the standing process, the formation state of the multilayer structure is checked by a microscopic monitoring device to verify that each layer is uniform and stable. After the standing is completed, a stable multilayer structure solution is obtained;

[0087] S13, homogenizing and mixing, adding the remaining part of the second matrix to the stable multilayer structure solution, stirring using a homogenizing device, maintaining the stirring speed at 300 RPM, and stirring for 15 minutes to obtain a homogenous paste.

[0088] S14, a paste-forming process, heating the homogenized paste, maintaining the heating temperature at 50° C. for 2 hours, filtering the paste using a filtering device after heating, and controlling the filter pore size at 1 mm. The filtered paste needs to be naturally cooled to room temperature to obtain a cooled paste;

[0089] S15, finished product packaging, the cooled paste is packaged, the packaging container is heated by a water bath, the water bath temperature is controlled at 55° C., and the paste is sealed after the packaging is completed to obtain the finished product of the 26th Imperial Prescription Blood Activating and Detoxifying Health Gel;

[0090] S16, finished product storage, placing the finished product of the 26 Imperial Prescriptions Blood Activating and Detoxifying Health Gel in a constant temperature storage device.

[0091] In this embodiment, in step S16, the storage temperature of the constant temperature storage device is set at 25° C. and the humidity is maintained at 40%.

[0092] Experimental methods:

[0093] Experimental method for drug release rate: The dissolution and release determination method of the second method of 0931 of the fourth general rules of the 2020 edition of the "Chinese Pharmacopoeia" was adopted. 900ml of aqueous solution was used as the dissolution medium, and the stirring speed was set to 50 rpm. The sampling time points were 5 minutes and 10 minutes. The chromatographic conditions of the dissolution experiment are as follows: the chromatographic column uses octadecylsilane bonded silica gel as a filler, the mobile phase is a mixture of water-methanol (70:30), the detection wavelength is 262nm, the column temperature is set to 25°C, and the flow rate is 1ml / min. The drug release rate is calculated by measuring the dissolution amount of the sample at different time points.

[0094] Moisturizing effect test method: The moisturizing effect test is evaluated by the change of moisture content on the skin surface. 20 healthy volunteers were selected and the samples were applied to the forearm skin with an application area of ​​5 square centimeters. The test was conducted under constant conditions of temperature 22±2℃ and humidity 45±5%. The skin moisture content was measured using a skin moisture tester 1 hour, 2 hours, 4 hours, 8 hours and 12 hours after application, and the data was recorded. The moisturizing effect of the product was evaluated by comparing the changes in moisture content before and after application.

[0095] Skin absorption rate test method: The skin absorption rate test uses an in vitro transdermal diffusion experiment. Select human skin or animal skin models and apply the sample evenly to the skin surface. Place the skin in a Franz diffusion cell, and the receiving chamber of the diffusion cell is a 37°C constant temperature water bath. The diffusion medium is phosphate buffer (pH 7.4), and samples are taken at 0, 1, 2, 4, and 8 hours. The sampling volume is 1 ml, and an equal amount of phosphate buffer is immediately added after each sampling. The samples are analyzed by high-performance liquid chromatography (HPLC), and the chromatographic conditions are consistent with the drug release rate experiment. The skin absorption rate is obtained by calculating the amount of drug that passes through the skin.

[0096] Antioxidant capacity experimental method: Antioxidant capacity is evaluated by DPPH free radical scavenging rate experiment. Prepare DPPH methanol solution (concentration is 0.1mmol / L), take samples of different concentrations (0.1, 0.2, 0.5, 1.0mg / ml) and mix them with DPPH solution. After reacting in the dark for 30 minutes, measure the absorbance at a wavelength of 517nm. Take DPPH solution as the blank control group, calculate the percentage of DPPH free radical scavenging by the sample, the formula is: free radical scavenging rate (%) = [(A0-A1) / A0] × 100, where A0 is the absorbance of the blank control, and A1 is the absorbance of the sample after reaction. Test the scavenging rate at different concentrations to obtain the antioxidant capacity of the sample.

[0097] The finished materials prepared in Examples 1-2 were tested, wherein Comparative Example 1 was a commercially available product, and the experimental method was as follows:

[0098] Table 1 Performance test data

[0099] Performance Indicators Comparative Example 1 Example 1 Example 2 Drug release rate (%) 60 85 90 Moisturizing effect (hours) 4 8 10 Skin absorption rate (%) 55 78 82 Antioxidant capacity (%) 45 75 80

[0100] As can be seen from Table 1, Example 1 and Example 2 have significant advantages over Comparative Example 1. In terms of drug release rate, Example 1 and Example 2 show a more efficient release effect, ensuring that the drug ingredients can be stably released in a shorter time. In terms of moisturizing effect, the moisturizing time of Example 1 and Example 2 is significantly extended, which can provide a lasting moisturizing effect and effectively improve the problem of dry skin. In terms of skin absorption rate, the absorption efficiency of Example 1 and Example 2 is better than that of Comparative Example 1, indicating that its formula is easier to penetrate the skin and can exert its efficacy faster. In the antioxidant capacity test, Example 1 and Example 2 showed stronger free radical scavenging ability and had better anti-aging and skin repair effects. These advantages make Example 1 and Example 2 have better performance in promoting blood circulation and detoxification, moisturizing and repairing, and anti-oxidation.

Claims

1. A blood-activating and detoxifying health gel, characterized in that: The blood-activating and detoxifying health gel comprises a first matrix and a second matrix, wherein the first matrix comprises the following components in parts by weight: 100-300 parts of Millettia reticulata, 100-300 parts of Scrophularia ningpoensis, 50-300 parts of honeysuckle, 50-300 parts of Lycopodiella cuneata, 50-300 parts of saffron, 25-150 parts of Smilax glabra, 25-150 parts of Burdock seeds, 25-150 parts of Ginkgo biloba leaves, 25-125 parts of Aloe vera, 25-150 parts of Frankincense, 10-150 parts of seaweed, 20-150 parts of Evening Primrose root, 5-150 parts of Konjac, 5-120 parts of Blueberry, 10-100 parts of Rose, 5-15 parts of Ganoderma lucidum; The second matrix comprises the following components in parts by weight: Thickener 1.2-3 parts, humectant 3-6 parts, glycerin 3-7 parts, pH adjuster 1-2 parts, antioxidant 0.01-0.5 parts, plant enzyme 0.01-0.5 parts, preservative 0.01-0.5 parts, collagen peptide 0.001-0.01 parts, sodium hyaluronate 0.1-0.5 parts, allantoin 0.01-0.07 parts, purified water 40-60 parts.

2. The blood-activating and detoxifying health gel according to claim 1, characterized in that: The thickener is any one of carbomer, xanthan gum, sodium carboxymethyl cellulose, guar gum and sodium alginate.

3. The blood-activating and detoxifying health gel according to claim 1, characterized in that: The moisturizing agent is any one of propylene glycol, butylene glycol and polyethylene glycol.

4. The blood-activating and detoxifying health gel according to claim 1, characterized in that: The pH adjuster is any one of triethanolamine, sodium hydroxide, potassium hydroxide, diethanolamine and boric acid.

5. The blood-activating and detoxifying health gel according to claim 1, characterized in that: The antioxidant is any one of yeast and lactic acid bacteria fermentation products.

6. The blood-activating and detoxifying health gel according to claim 1, characterized in that: The preservative is any one of phenoxyethanol, sodium benzoate, ethylhexylglycerin, hexylene glycol and methylisothiazolinone.

7. A method for preparing a blood-activating and detoxifying health gel, characterized in that: The following steps are involved: S1, decocting the first matrix medicinal material, adding Millettia spatholobi, Scrophularia ningpoensis, Honeysuckle, Lycopodiella cuneata, Crocus, Smilax glabra, Burdock fruit, Ginkgo biloba, Aloe vera, Frankincense, Seaweed, Evening primrose root, Konjac, Blueberry, Rose and Ganoderma lucidum to a reactor, controlling the proportion of water to 5 times, 2 times and 1.5 times the weight of the medicinal materials, decocting three times, maintaining the heating temperature between 80-100° C., and the decoction time for each time is 30 minutes. After each decoction, filtering the medicinal liquid, controlling the filter pore size between 0.5-1 mm, combining the three decoctions and continuing to heat and concentrate, concentrating to 2-3 times the amount of the crude drug, maintaining the temperature between 70-90° C. during the concentration process, and obtaining the decoction supernatant; S2, aqueous phase preparation, introducing the decoction supernatant into a stirring device, turning on the stirring device, controlling the speed between 200-300 RPM, adding purified water, maintaining the temperature between 50-60° C. during stirring, allowing the decoction and water to be evenly mixed, and controlling the stirring time to be 5-10 minutes. After the stirring is completed, using a temperature sensor to detect the temperature of the solution to ensure that the temperature is evenly maintained within the set range, thereby obtaining an aqueous phase solution; S3, oil phase preparation, the aqueous phase solution is allowed to stand for 10-20 minutes, and then glycerin, antioxidant, preservative, plant enzyme, moisturizer and pH adjuster are added to the reaction kettle in order by weight, the temperature of the oil phase mixture is maintained between 60-80° C., the speed of the stirring device is set to 200-400 RPM, and the stirring time is 10-20 minutes to obtain an oil phase solution; S4, two-phase emulsification treatment, gradually adding the aqueous phase solution to the oil phase solution, using a quantitative pump during the addition, the pumping speed is controlled at 1-5L / min, the aqueous phase and the oil phase are fully contacted, the speed of the stirring device is set to 230-500RPM, the stirring temperature is maintained between 60-70°C, the emulsification time is controlled at 15-30 minutes, and the diameter of the emulsified particles is controlled at 1-10 microns to obtain an emulsified solution; S5, ultrasonic pretreatment, performing ultrasonic treatment on the emulsified solution, setting the ultrasonic frequency to 20-40 kHz, and the treatment time to 5-10 minutes to obtain an ultrasonically treated emulsified solution; S6, preparation of the second matrix, adding the thickener, collagen peptide, sodium hyaluronate and allantoin by weight into the stirrer, the order of adding the easily soluble components first, and then the insoluble components, the stirring speed is controlled at 200-400RPM, the stirring time is 5-10 minutes, and the temperature is maintained between 25-30°C to obtain the second matrix solution; S7, ultrasonic homogenization treatment, gradually adding the ultrasonic treatment emulsified solution into the second matrix solution, using an ultrasonic homogenization device, the device frequency is set between 20-30kHz, the homogenization treatment time is set to 10-20 minutes, so that each component is evenly dispersed in the matrix solution to obtain a homogenous emulsified solution, S8, bubble atomization preparation, stirring the homogeneous emulsified solution, and then using a high-pressure bubble generating device, the air pressure of the bubble generating device is set to a range of 500-1000 Pa, and the bubbles are injected into the agitator, the gas injection time is maintained at 10-15 minutes, and the bubble diameter is controlled between 20-100 microns to obtain a bubble atomized solution; S9, bubble atomization condensation treatment, performing condensation treatment in the bubble atomization solution, using a condensation device to reduce the temperature of the solution to between 10-20° C., and controlling the condensation time to between 5-10 minutes to obtain a condensed emulsified solution; S10, micron bubble injection, using a micron bubble generating device for the condensed emulsified solution, the air pressure of the bubble generating device is maintained between 200-500 Pa, the bubble diameter is controlled within the range of 1-10 microns, and the injection time is set to 5-10 minutes to obtain a micron bubble emulsified solution; S11, electrostatic spray treatment, applying electrostatic spray technology to the micron bubble emulsified solution, spraying charged particles uniformly into the solution through an electrostatic spray device, setting the electrostatic voltage to 20-50 kV, and the treatment time to 5-10 minutes. The diameter of the charged particles is controlled to be between 1-5 microns, and the particles are uniformly distributed on the surface of the solution through the electrostatic field, and a multilayer structure is formed in the solution. After the spray treatment is completed, a multilayer emulsified solution is obtained; S12, multilayer structure formation, the multilayer emulsified solution is allowed to stand at a temperature between 25-35° C. for 30-60 minutes. During the standing process, the formation state of the multilayer structure is checked by a microscopic monitoring device to verify that each layer structure is uniform and stable. After the standing is completed, a stable multilayer structure solution is obtained; S13, homogenous mixing, adding the remaining part of the second matrix to the stable multilayer structure solution, stirring using a homogenizing device, maintaining the stirring speed between 300-500 RPM, and stirring for 15-30 minutes to obtain a homogenous paste.

8. The method for preparing the blood-activating and detoxifying health gel according to claim 7, characterized in that: Also includes: S14, a paste-forming step, heating the homogenized paste, maintaining the heating temperature between 50-60° C. for 2-3 hours, filtering the paste using a filtering device after heating, controlling the filter pore size between 0.5-1 mm, and naturally cooling the filtered paste to room temperature to obtain a cooled paste; S15, finished product packaging, the cooled paste is packaged, the packaging container is heated by a water bath, the water bath temperature is controlled between 55-60° C., and the paste is sealed after the packaging is completed to obtain a finished product of a blood-activating and detoxifying health gel; S16, finished product storage, placing the finished product of the blood-activating and detoxifying health-care gel in a constant temperature storage device.

9. The method for preparing the blood-activating and detoxifying health gel according to claim 8, characterized in that: In step S16, the storage temperature of the constant temperature storage device is set between 15-25°C, and the humidity is maintained between 40-60%.

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