Spray composition and preparation method thereof

Abstract

The invention relates to a spray composition and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations, the spray composition comprises the following components by weight: 2-4 parts of sucralfate wet gel, 5-10 parts of an active component, 0.5-0.8 part of a preservative, 0.7-1 part of a film-forming agent, 1-3 parts of a stabilizer, and the balance of purified water, totaling 200 parts. The sucralfate wet gel disclosed by the invention has an anti-inflammatory effect, is uniformly sprayed on the surface of an affected part in an atomizing manner, can better repair the surface of the ulcer affected part, is easily dissolved in pure water, and can be dissolved more sufficiently compared with a preparation method of grinding sucralfate aluminum into powder; and the solubility of sucralfate in pure water is improved, so that the sucralfate can exert the medicine property better.

Description

Technical Field

[0001] The invention belongs to the technical field of pharmaceutical preparations, and specifically relates to a spray composition and a preparation method thereof. Background Art

[0002] Sucralfate is an effective anti-peptic ulcer drug that protects the ulcer surface and promotes wound healing. It can be used topically for inflammatory diseases. However, in the prior art, local medication to the affected area is applied directly, which does not spread evenly on the affected area and is not conducive to the recovery of the affected area. Summary of the invention

[0003] The purpose of the present invention is to provide a spray composition with simple structure and reasonable design and a preparation method thereof in order to solve the above problems.

[0004] The present invention achieves the above-mentioned purpose through the following technical solutions:

[0005] A spray composition, wherein the atomizer is composed of the following components in weight ratio:

[0006] 2-4 parts of sucralfate wet gel, 5-10 parts of active ingredients, 0.5-0.8 parts of preservatives, 0.7-1 parts of film-forming agents, 1-3 parts of stabilizers, and purified water to make up to 200 parts.

[0007] As a further optimization scheme of the present invention, the active ingredient is sodium methyl parahydroxybenzoate, which has an antibacterial effect when sprayed on the affected area.

[0008] As a further optimization scheme of the present invention, the preservative is sodium propyl p-hydroxybenzoate, which is used to prevent microbial contamination, ensure product safety and extend shelf life.

[0009] As a further optimization scheme of the present invention, the film-forming agent is polyvinyl alcohol, which is non-toxic to the human body, has no side effects, and has good biocompatibility.

[0010] As a further optimization scheme of the present invention, the stabilizer adopts disodium hydrogen phosphate, a water-locking stabilizer, to allow sucralfate to undergo chemical changes during storage and use, thereby maintaining its stability and effectiveness.

[0011] As a further optimization scheme of the present invention, the purified water is one of deionized water or distilled water.

[0012] A method for preparing a spray comprises the following steps:

[0013] a. Preparation of raw materials: Accurately weigh each raw material according to the determined ratio;

[0014] b. Slowly add the sucralfate wet gel into pure water, stirring while adding until it is completely dissolved, then add a certain amount of active ingredients, stabilizers, and preservatives at one time, and continue stirring until all ingredients are fully mixed;

[0015] c. Adjust the pH value: As needed, use an appropriate amount of acid-base regulator to adjust the pH value of the solution to an appropriate range to improve the stability and comfort of the product;

[0016] d. Filtration and filling: Filter the prepared solution through a precision filter to remove impurities and particles, and then fill the filtered solution into a special spray bottle. Pay attention to avoid contamination during the filling process;

[0017] e. Sealing and inspection: The filled spray should be sealed and preliminary inspection of appearance, filling volume, pH value, etc. should be carried out to ensure the product quality.

[0018] The beneficial effects of the present invention are:

[0019] 1. The sucralfate wet gel in the present invention has an anti-inflammatory effect and can be evenly sprayed on the surface of the affected area in an atomized manner, thereby better repairing the surface of the ulcer affected area.

[0020] 2. The sucralfate wet gel in the present invention is easily dissolved in pure water, and can be dissolved more fully than sucralfate tablets ground into powder, thereby improving the solubility of sucralfate in pure water and enabling sucralfate to exert its medicinal properties to a greater extent. DETAILED DESCRIPTION

[0021] The present application is further described in detail below in conjunction with the accompanying drawings. It is necessary to point out here that the following specific implementation methods are only used to further illustrate the present application and cannot be understood as limiting the scope of protection of the present application. Technical personnel in this field can make some non-essential improvements and adjustments to the present application based on the above application content.

[0022] Example 1

[0023] The spray of the present invention is prepared from the following components by weight: 2 parts of sucralfate wet gel, 10 parts of sodium methyl parahydroxybenzoate, 0.5 parts of propyl sodium parahydroxybenzoate, 1 part of polyvinyl alcohol, 3 parts of disodium hydrogen phosphate, and purified water to make up to 200 parts.

[0024] Sodium methyl paraben sprayed on the affected area has an antibacterial effect. Sodium propyl paraben is used to prevent microbial contamination, ensure the safety of the product and extend the shelf life. Polyvinyl alcohol is non-toxic and has no side effects to the human body and has good biocompatibility. Disodium hydrogen phosphate is used to prevent chemical changes in sucralfate during storage and use to maintain its stability and effectiveness. Purified water is a type of deionized water or distilled water.

[0025] In order to solve the above technical problems, the technical solution adopted by the present invention is: comprising the following steps:

[0026] a. Preparation of raw materials: Accurately weigh each raw material according to the determined ratio;

[0027] b. Slowly add the sucralfate wet gel into pure water, stirring while adding until it is completely dissolved, then add a certain amount of active ingredients, stabilizers, and preservatives at one time, and continue stirring until all ingredients are fully mixed;

[0028] c. Adjust the pH value: As needed, use an appropriate amount of acid-base regulator to adjust the pH value of the solution to an appropriate range to improve the stability and comfort of the product;

[0029] d. Filtration and filling: Filter the prepared solution through a precision filter to remove impurities and particles, and then fill the filtered solution into a special spray bottle. Pay attention to avoid contamination during the filling process;

[0030] e. Sealing and inspection: The filled spray should be sealed and preliminary inspection of appearance, filling volume, pH value, etc. should be carried out to ensure the product quality.

[0031] Example 2

[0032] The spray of the present invention is prepared from the following components by weight: 3 parts of sucralfate wet gel, 7 parts of sodium methyl parahydroxybenzoate, 0.7 parts of sodium propyl parahydroxybenzoate, 0.8 parts of polyvinyl alcohol, 2 parts of disodium hydrogen phosphate, and purified water to make up to 200 parts.

[0033] Sodium methyl paraben sprayed on the affected area has an antibacterial effect. Sodium propyl paraben is used to prevent microbial contamination, ensure the safety of the product and extend the shelf life. Polyvinyl alcohol is non-toxic and has no side effects to the human body and has good biocompatibility. Disodium hydrogen phosphate is used to prevent chemical changes in sucralfate during storage and use to maintain its stability and effectiveness. Purified water is a type of deionized water or distilled water.

[0034] In order to solve the above technical problems, the technical solution adopted by the present invention is: comprising the following steps:

[0035] a. Preparation of raw materials: Accurately weigh each raw material according to the determined ratio;

[0036] b. Slowly add the sucralfate wet gel into pure water, stirring while adding until it is completely dissolved, then add a certain amount of active ingredients, stabilizers, and preservatives at one time, and continue stirring until all ingredients are fully mixed;

[0037] c. Adjust the pH value: As needed, use an appropriate amount of acid-base regulator to adjust the pH value of the solution to an appropriate range to improve the stability and comfort of the product;

[0038] d. Filtration and filling: Filter the prepared solution through a precision filter to remove impurities and particles, and then fill the filtered solution into a special spray bottle. Pay attention to avoid contamination during the filling process;

[0039] e. Sealing and inspection: The filled spray should be sealed and preliminary inspection of appearance, filling volume, pH value, etc. should be carried out to ensure the product quality.

[0040] Example 3

[0041] The spray of the present invention is prepared from the following components by weight: 4 parts of sucralfate wet gel, 5 parts of methyl parahydroxybenzoate sodium, 0.8 parts of propyl sodium parahydroxybenzoate, 0.7 parts of polyvinyl alcohol, 1 part of disodium hydrogen phosphate, and purified water to make up to 200 parts.

[0042] Sodium methyl paraben sprayed on the affected area has an antibacterial effect. Sodium propyl paraben is used to prevent microbial contamination, ensure the safety of the product and extend the shelf life. Polyvinyl alcohol is non-toxic and has no side effects to the human body and has good biocompatibility. Disodium hydrogen phosphate is used to prevent chemical changes in sucralfate during storage and use to maintain its stability and effectiveness. Purified water is a type of deionized water or distilled water.

[0043] In order to solve the above technical problems, the technical solution adopted by the present invention is: comprising the following steps:

[0044] a. Preparation of raw materials: Accurately weigh each raw material according to the determined ratio;

[0045] b. Slowly add the sucralfate wet gel into pure water, stirring while adding until it is completely dissolved, then add a certain amount of active ingredients, stabilizers, and preservatives at one time, and continue stirring until all ingredients are fully mixed;

[0046] c. Adjust the pH value: As needed, use an appropriate amount of acid-base regulator to adjust the pH value of the solution to an appropriate range to improve the stability and comfort of the product;

[0047] d. Filtration and filling: Filter the prepared solution through a precision filter to remove impurities and particles, and then fill the filtered solution into a special spray bottle. Pay attention to avoid contamination during the filling process;

[0048] e. Sealing and inspection: The filled spray should be sealed and preliminary inspection of appearance, filling volume, pH value, etc. should be carried out to ensure the product quality.

[0049] The above-mentioned embodiments only express several implementation methods of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the scope of the present invention. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, which all belong to the protection scope of the present invention.

Claims

1. A spray composition, characterized in that: The atomizer is composed of the following components in weight ratio: 2-4 parts of sucralfate wet gel, 5-10 parts of active ingredients, 0.5-0.8 parts of preservatives, 0.7-1 parts of film-forming agents, 1-3 parts of stabilizers, and purified water to make up to 200 parts.

2. A spray composition according to claim 1, characterized in that: The active ingredient is sodium methyl parahydroxybenzoate, which has an antibacterial effect when sprayed on the affected area.

3. A spray composition according to claim 1, characterized in that: The preservative is sodium propylparaben, which is used to prevent microbial contamination, ensure product safety and extend shelf life.

4. A spray composition according to claim 1, characterized in that: The film-forming agent is polyvinyl alcohol, which is non-toxic to the human body, has no side effects, and has good biocompatibility.

5. A spray composition according to claim 1, characterized in that: The stabilizer adopts disodium hydrogen phosphate, a water-locking stabilizer, which is used to prevent sucralfate from undergoing chemical changes during storage and use, thereby maintaining its stability and effectiveness.

6. A spray composition according to claim 1, characterized in that: The purified water is deionized water or distilled water.

7. A method for preparing a spray according to claims 1-7, characterized in that: The steps include: a. Preparation of raw materials: Accurately weigh each raw material according to the determined ratio; b. Slowly add the sucralfate wet gel into pure water, stirring while adding until it is completely dissolved, then add a certain amount of active ingredients, stabilizers, and preservatives at one time, and continue stirring until all ingredients are fully mixed; c. Adjust the pH value: As needed, use an appropriate amount of acid-base regulator to adjust the pH value of the solution to an appropriate range to improve the stability and comfort of the product; d. Filtration and filling: Filter the prepared solution through a precision filter to remove impurities and particles, and then fill the filtered solution into a special spray bottle. Pay attention to avoid contamination during the filling process; e. Sealing and inspection: The filled spray should be sealed and preliminary inspection of appearance, filling volume, pH value, etc. should be carried out to ensure the product quality.