Traditional Chinese medicine composition for treating heart-spleen deficiency type megee syndrome

Abstract

The invention provides a traditional Chinese medicine composition for treating heart-spleen deficiency type megee syndrome, and relates to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition is prepared from thirteen traditional Chinese medicines including longan aril, poria cocos, rhizoma polygonati, tortoise shells, codonopsis pilosula, Chinese yam, white hyacinth beans, Chinese dates, lucid ganoderma, agilawood, lindera aggregata, roses and cortex albiziae. The traditional Chinese medicine composition takes heart and spleen tonifying as a main treatment principle, has the effects of invigorating spleen to eliminate dampness, tranquilizing and allaying excitement, securing essence and promoting salivation, promoting qi circulation to relieve pain, absorbing qi and relieving asthma and the like, can obviously relieve the symptoms of double-eyelid spasm, frequent blinking, dysphagia, insomnia and dreaminess and the like of heart and spleen deficiency type meiger syndrome patients, and is good in treatment effect, free of toxic and side effects and not prone to relapse.

Description

Technical Field

[0001] The invention relates to the technical field of Chinese medicine compositions, and in particular to a Chinese medicine composition for treating Meige syndrome of heart and spleen deficiency type. Background Art

[0002] Meige syndrome, also known as idiopathic blepharospasm-oromandibular dystonia syndrome, often presents with blepharospasm as the first symptom, accompanied by frequent blinking, difficulty opening the eyes, and involuntary muscle movements in the mouth and jaw. Currently, the treatment of Meige syndrome includes conservative medical treatment and surgical treatment. Medical treatment includes anticholinergic drugs, antiepileptic drugs, antipsychotic drugs, dopaminergic drugs, muscle relaxants and botulinum toxin injections, but the efficacy of these drugs is not ideal and the side effects are large. Patients often reduce or stop taking the drugs due to poor efficacy or difficulty tolerating the side effects. The main surgical method used in surgical treatment is deep brain stimulation, but it has many complications and is difficult for patients to accept.

[0003] Traditional Chinese medicine has unique advantages in the treatment of Meige syndrome. It is good at looking at the etiology and pathogenesis from a holistic perspective. It can be used for syndrome differentiation and treatment according to the etiology, syndrome type, clinical manifestations, and accompanying symptoms. Compared with Western medicine, traditional Chinese medicine treatment has the advantages of good therapeutic effect, low cost, and high safety. Traditional Chinese medicine classifies Meige syndrome into the categories of "eyelid twitching", "eye wind", "spasm", and "muscle twitching and muscle spasm", including the two major syndrome types of "heart and spleen deficiency type" and "blood deficiency and wind type". Meige syndrome of heart and spleen deficiency type is often manifested as eyelid twitching, eyelid spasm, some of which start from one eye and gradually affect both eyes; patients have constant blinking, twitching of the corners of the mouth, or involuntary twitching of the neck forward or to one side, accompanied by a feeling of sobbing and difficulty swallowing; the symptoms of eyelid spasm disappear when patients are quiet or sleeping; palpitations and insomnia, forgetfulness and dreams, heavy when tired, restlessness and insomnia, less appetite and fatigue. The "Classic of Classics" says: "The eyelids are the eyelids, which can open and close. They are the essence of muscles and are controlled by the spleen." All muscles in the human body are controlled by the spleen, which is the foundation of the acquired constitution. The abnormal transportation and transformation function of the spleen causes the skin and flesh to lose nourishment, so the opening and closing are dysfunctional. Therefore, the treatment principle for Meige syndrome of heart and spleen deficiency is to mainly nourish the heart and spleen. At present, many Chinese medicine prescriptions for the treatment of Meige syndrome have been disclosed, but there is no Chinese medicine prescription for Meige syndrome of heart and spleen deficiency. Based on this, the present invention aims to provide a Chinese medicine composition for Meige syndrome of heart and spleen deficiency with good efficacy, few side effects, and low recurrence. Summary of the invention

[0004] 1. Technical issues to be solved

[0005] In view of the deficiencies in the prior art, the present invention provides a traditional Chinese medicine composition for treating Meige syndrome of heart and spleen deficiency type.

[0006] (II) Technical solution

[0007] To achieve the above objectives, the present invention is implemented through the following technical solutions:

[0008] On the one hand, the present invention provides a traditional Chinese medicine composition for treating Meige syndrome of heart and spleen deficiency type, wherein the traditional Chinese medicine composition is composed of the following raw materials in parts by weight: 20-50 parts of longan pulp, 10-25 parts of Poria cocos, 10-30 parts of Polygonatum sibiricum, 10-30 parts of tortoise shell, 20-50 parts of Codonopsis pilosula, 10-30 parts of yam, 15-35 parts of white labiatae, 6-36 parts of jujube, 1-8 parts of Ganoderma lucidum, 1-5 parts of agarwood, 5-15 parts of Linderae serrata, 1-8 parts of rose, and 10-30 parts of Albizzia julibrissin bark.

[0009] Furthermore, the Chinese medicine composition is composed of the following raw materials in parts by weight: 30-45 parts of longan pulp, 15-20 parts of Poria cocos, 15-25 parts of Polygonatum sibiricum, 15-25 parts of tortoise shell, 30-40 parts of Codonopsis pilosula, 15-25 parts of yam, 20-30 parts of white hyacinth bean, 15-25 parts of jujube, 3-5 parts of Ganoderma lucidum, 1-3 parts of agarwood, 7-12 parts of Linderae serrata, 2-6 parts of rose, and 15-25 parts of Albizzia julibrissin bark.

[0010] Furthermore, the Chinese medicine composition is composed of the following raw materials in parts by weight: 36 parts of longan pulp, 18 parts of Poria cocos, 22 parts of Polygonatum sibiricum, 20 parts of tortoise shell, 34 parts of Codonopsis pilosula, 18 parts of yam, 26 parts of white hyacinth bean, 20 parts of jujube, 4 parts of Ganoderma lucidum, 2 parts of agarwood, 10 parts of Linderae serrata, 5 parts of rose, and 18 parts of Albizzia julibrissin bark.

[0011] The Chinese medicine composition provided by the present invention is used to prepare a medicine for treating Meige syndrome of heart and spleen deficiency type. The Chinese medicine composition is prepared into granules, powders, oral liquids, pills, decoctions or other pharmaceutically acceptable oral dosage forms according to conventional pharmaceutical methods in pharmacy and with medically acceptable adjuvants.

[0012] A Chinese medicine decoction for treating Meige syndrome of heart and spleen deficiency is prepared according to the following steps:

[0013] (1) Weigh the ingredients according to the above weight proportions, add water until the water level is 2-3 cm above the medicinal materials, and soak for 20-30 minutes.

[0014] (2) Transfer the tortoise shell and soaking liquid to a casserole and boil them. Then, simmer them for 20-30 minutes over low heat. Then, add the remaining medicinal materials and simmer for 20-30 minutes. Filter the decoction while it is still hot.

[0015] (3) Add water to the casserole again and bring to a boil, then simmer for 15-20 minutes. Filter the decoction while it is still hot, and combine the two decoctions to obtain the mixture.

[0016] The pharmacological effects of each Chinese medicine component in the Chinese medicine composition of the present invention are as follows:

[0017] Longan meat: sweet in taste, warm in nature, and enters the heart and spleen meridians; it has the effects of benefiting the heart and spleen, replenishing qi and blood, and calming the mind; it is used for qi and blood deficiency, palpitations, forgetfulness and insomnia, and blood deficiency and chlorosis. Modern pharmacological studies have shown that longan meat contains sugars, saponins, polypeptides, polyphenols and other ingredients, which have antibacterial, sedative, stomachic, antioxidant, immunomodulatory, hypoglycemic, and anti-fatigue pharmacological activities.

[0018] Poria: sweet, light, neutral in nature, enters the heart, lung, spleen, and kidney meridians; has the effects of diuresis, invigorating the spleen, and calming the mind; used for edema, oliguria, phlegm, dizziness, palpitations, spleen deficiency, poor appetite, loose stools, restlessness, palpitations, insomnia. Modern pharmacological studies have shown that Poria contains chemical components such as polysaccharides, diterpenes, triterpenes, sterols, phosphates, etc., and has anti-tumor, immune regulation, lipid metabolism regulation, kidney protection, heart protection, liver protection, etc.

[0019] Polygonatum: sweet in taste, neutral in nature, enters the spleen, lung, and kidney meridians; has the effects of replenishing qi and nourishing yin, strengthening the spleen, moistening the lungs, and benefiting the kidneys; used for spleen and stomach qi deficiency, fatigue, insufficient stomach yin, dry mouth and poor appetite, dry cough due to lung deficiency, cough with blood due to overwork, insufficient menstrual blood, soreness of waist and knees, premature graying of hair, internal heat and thirst. Modern pharmacological studies have shown that Polygonatum contains chemical components such as sugars, flavonoids, terpenes, alkaloids, cardiac glycosides, lignans, etc., and has pharmacological activities such as anti-oxidation, regulating immunity, nourishing nerves, enhancing memory, lowering blood sugar and lipids, anti-inflammatory and bactericidal, anti-fatigue, and anti-cancer.

[0020] Turtle shell: salty and sweet in taste, slightly cold in nature, enters the liver, kidney, and heart meridians; has the effects of nourishing yin and suppressing yang, benefiting the kidneys and strengthening bones, nourishing blood and replenishing the heart, consolidating menstruation and stopping metrorrhagia; used for hot flashes due to yin deficiency, night sweats due to bone steaming, dizziness, internal movement of virtual wind, weakness of tendons and bones, forgetfulness due to heart deficiency, and excessive metrorrhagia.

[0021] Codonopsis: sweet in taste, neutral in nature, enters the spleen and lung meridians, has the effects of strengthening the spleen and lungs, nourishing blood and producing body fluids; used for spleen and lung qi deficiency, poor appetite and fatigue, cough and asthma, qi and blood deficiency, sallow complexion, palpitations and shortness of breath, thirst due to loss of body fluids, internal heat and thirst. Modern pharmacological studies have shown that Codonopsis contains phenylpropanoids, polyacetylene, terpenes, alkaloids, polysaccharides, sterols, volatile oils, amino acids and trace elements, and has pharmacological activities such as anti-tumor, anti-aging, intelligence-enhancing, analgesic, expectorant, antitussive, and improvement of microcirculatory disorders.

[0022] Chinese Yam: Sweet in taste, neutral in nature, enters the spleen, lung, and kidney meridians; has the effects of nourishing the spleen and stomach, promoting fluid production and benefiting the lungs, nourishing the kidneys and astringing semen, and is used for spleen deficiency, poor appetite, chronic diarrhea, cough and asthma due to lung deficiency, spermatorrhea due to kidney deficiency, leucorrhea, frequent urination, and thirst due to deficiency heat. Modern pharmacological studies have shown that Chinese Yam contains chemical components such as polysaccharides, amino acids, fatty acids, and yam, and has pharmacological activities such as lowering blood sugar, lowering blood lipids, anti-oxidation, regulating the spleen and stomach, anti-tumor, and immunomodulation.

[0023] White lentil: sweet in taste, slightly warm in nature, and enters the spleen and stomach meridians; it has the effects of strengthening the spleen and eliminating dampness, harmonizing the middle and relieving heat; it is used for weak spleen and stomach, loss of appetite, sugary stools, excessive leucorrhea, vomiting and diarrhea due to summer heat, chest tightness and abdominal distension. Modern pharmacological research shows that white lentil contains polysaccharides, proteins, fatty acids, calcium, iron, phosphorus, vitamins and other nutrients, and has pharmacological activities such as antibacterial, antiviral, antioxidant, and liver protection.

[0024] Jujube: sweet in taste, warm in nature, enters the spleen, stomach, and heart meridians; has the effects of tonifying the middle qi, nourishing blood, and calming the mind; used for spleen deficiency, poor appetite, fatigue, loose stools, and irritability in women. Modern pharmacological research shows that jujube contains chemical components such as sugars, terpenes, alkaloids, flavonoids, amino acids, and vitamins, which have pharmacological activities such as enhancing immunity, inhibiting cancer cell proliferation, protecting the liver, and resisting type I allergic reactions.

[0025] Lingzhi: sweet in taste, neutral in nature, enters the heart, lung, liver, and kidney meridians; has the effects of replenishing qi and calming the mind, relieving cough and relieving asthma; used for restlessness, insomnia, palpitations, lung deficiency, cough and asthma, shortness of breath due to consumptive disease, and loss of appetite. Modern pharmacological studies have shown that Lingzhi contains chemical components such as triterpenes, polysaccharides, proteins, and sterols, and has pharmacological activities such as improving immunity, anti-tumor, antibacterial, anti-inflammatory, and antioxidant.

[0026] Agarwood: It tastes spicy and bitter, is slightly warm in nature, and enters the spleen, stomach, and kidney meridians; it has the effects of promoting qi and relieving pain, warming the middle and stopping vomiting, and relieving asthma; it is used for chest and abdominal distension and pain, stomach cold, vomiting and hiccups, and kidney deficiency, qi reversal and asthma. Modern pharmacological studies have shown that agarwood contains chemical components such as sesquiterpenes and chromones, which have pharmacological activities such as sedation and analgesia, antibacterial, anti-tumor, and inhibition of acetylcholinesterase.

[0027] Linderae odoratum: spicy, warm in nature, enters the lung, spleen, kidney, and bladder meridians; has the effects of promoting qi and relieving pain, warming the kidney and dispersing cold; used for cold stagnation and qi stagnation, chest and abdominal distension and pain, qi reversal and shortness of breath, bladder deficiency and coldness, enuresis and frequent urination, hernia pain, and abdominal pain caused by cold menstruation. Modern pharmacological studies have shown that Linderae odoratum contains chemical components such as sesquiterpenes, alkaloids, volatile oils, cyclopentadione, and flavonoids, and has pharmacological activities such as anti-inflammatory and analgesic, liver protection, lipid-lowering, anti-tumor, antioxidant, and treatment of chronic kidney disease.

[0028] Rose: Sweet, slightly bitter, warm in nature, enters the liver and spleen meridians; has the effects of promoting qi and relieving depression, harmonizing blood, and relieving pain; used for liver and stomach pain, loss of appetite, nausea, irregular menstruation, and pain from falls. Modern pharmacological studies have shown that rose contains chemical components such as volatile oils, flavonoids, polyphenols, polysaccharides, proteins, and amino acids, and has pharmacological activities such as anti-oxidation, antibacterial, hypoglycemic, hypolipidemic, anti-tumor, prevention of cardiovascular diseases, and anti-depression.

[0029] Albizzia julibrissin: sweet, neutral in nature, enters the heart, liver, and lung meridians; has the effects of relieving depression and calming the mind, promoting blood circulation and reducing swelling; used for restlessness, depression and insomnia, lung abscess, sores, and pain from falls. Modern pharmacological studies have shown that Albizzia julibrissin contains chemical components such as triterpenes, lignans, flavonoids, and sterols, and has pharmacological activities such as anti-tumor, antibacterial, anti-anxiety, anti-depression, anti-inflammatory, immune enhancement, and antioxidant.

[0030] (III) Beneficial effects

[0031] The present invention takes tonifying the heart and spleen as the main treatment principle, follows the principle of treatment based on syndrome differentiation in traditional Chinese medicine, and reasonably combines the ingredients to obtain a Chinese medicine composition for treating Meige syndrome of heart and spleen deficiency, which consists of thirteen Chinese medicinal herbs, including longan pulp, Poria cocos, Polygonatum sibiricum, tortoise shell, Codonopsis pilosula, yam, white hyacinth bean, jujube, Ganoderma lucidum, agarwood, Linderae umbellatae, rose and Albizzia julibrissin bark. In the prescription, longan pulp and Poria cocos are used as the main medicines, which can nourish the heart and spleen, nourish blood and calm the mind, and promote diuresis and eliminate dampness; Polygonatum sibiricum, tortoise shell, Codonopsis pilosula, and Chinese yam are used as the ministerial medicines, which can nourish the spleen and replenish qi, nourish blood and invigorate the heart, invigorate the kidney and strengthen bones, and consolidate the essence and produce body fluid; White hyacinth bean, jujube, ganoderma lucidum, and agarwood are used as adjuvants, which can invigorate the spleen and eliminate dampness, strengthen tendons and bones, calm the mind, promote qi and stop pain, promote qi and relieve asthma, and warm the middle and stop vomiting; Linderae sibiricum, rose flower, and Albizzia julibrissin bark are used as the guiding medicines, which can warm the kidney and dispel cold, promote qi and relieve depression, and promote blood circulation and reduce swelling; the combination of the medicines has the effects of invigorating the spleen and eliminating dampness, calming the mind, consolidating the essence and producing body fluid, promoting qi and stopping pain, and promoting qi and relieving asthma. The Chinese medicine composition of the present invention can significantly alleviate the clinical symptoms of eyelid spasm, frequent blinking, dysphagia, insomnia and dreaminess in patients with Meige syndrome of heart and spleen deficiency type, and has good therapeutic effect, no toxic side effects, and is not easy to relapse. DETAILED DESCRIPTION

[0032] In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution in the embodiments of the present invention will be clearly and completely described below in combination with the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0033] Example 1

[0034] A traditional Chinese medicine composition for treating Meige syndrome of heart and spleen deficiency type, the traditional Chinese medicine composition is composed of the following raw materials in parts by weight: 36 parts of longan pulp, 18 parts of Poria cocos, 22 parts of polygonatum, 20 parts of tortoise shell, 34 parts of Codonopsis pilosula, 18 parts of yam, 26 parts of white hyacinth bean, 20 parts of jujube, 4 parts of Ganoderma lucidum, 2 parts of agarwood, 10 parts of Linderae umbellatae, 5 parts of rose, and 18 parts of Albizzia julibrissin bark.

[0035] Example 2

[0036] The difference between this embodiment and embodiment 1 is that the Chinese medicine composition is composed of the following raw materials in parts by weight: 20 parts of longan pulp, 10 parts of Poria cocos, 10 parts of Polygonatum sibiricum, 10 parts of tortoise shell, 20 parts of Codonopsis pilosula, 10 parts of yam, 15 parts of white labiatae, 6 parts of jujube, 1 part of Ganoderma lucidum, 1 part of agarwood, 5 parts of Linderae sibiricum, 1 part of rose, and 10 parts of Albizzia julibrissin bark.

[0037] Example 3

[0038] The difference between this embodiment and embodiment 1 is that the Chinese medicine composition is composed of the following raw materials in parts by weight: 40 parts of longan pulp, 20 parts of Poria cocos, 24 parts of Polygonatum sibiricum, 20 parts of tortoise shell, 36 parts of Codonopsis pilosula, 20 parts of yam, 28 parts of white hyacinth bean, 22 parts of jujube, 5 parts of Ganoderma lucidum, 3 parts of agarwood, 12 parts of Linderae serrata, 5 parts of rose, and 20 parts of Albizzia julibrissin bark.

[0039] Example 4

[0040] The difference between this embodiment and embodiment 1 is that the Chinese medicine composition is composed of the following raw materials in parts by weight: 32 parts of longan pulp, 15 parts of Poria cocos, 18 parts of Polygonatum sibiricum, 15 parts of tortoise shell, 28 parts of Codonopsis pilosula, 15 parts of yam, 20 parts of white hyacinth bean, 18 parts of jujube, 4 parts of Ganoderma lucidum, 3 parts of agarwood, 10 parts of Linderae serrata, 4 parts of rose, and 18 parts of Albizzia julibrissin bark.

[0041] Example 5

[0042] The difference between this embodiment and embodiment 1 is that the Chinese medicine composition is composed of the following raw materials in parts by weight: 28 parts of longan pulp, 13 parts of Poria cocos, 15 parts of Polygonatum sibiricum, 13 parts of tortoise shell, 25 parts of Codonopsis pilosula, 13 parts of yam, 18 parts of white hyacinth bean, 15 parts of jujube, 3 parts of Ganoderma lucidum, 2 parts of agarwood, 8 parts of Linderae serrata, 3 parts of rose, and 15 parts of Albizzia julibrissin bark.

[0043] Example 6

[0044] The difference between this embodiment and embodiment 1 is that the Chinese medicine composition is composed of the following raw materials in parts by weight: 50 parts of longan pulp, 25 parts of Poria cocos, 30 parts of Polygonatum sibiricum, 30 parts of tortoise shell, 50 parts of Codonopsis pilosula, 30 parts of yam, 35 parts of white hyacinth bean, 36 parts of jujube, 8 parts of Ganoderma lucidum, 5 parts of agarwood, 15 parts of Linderae serrata, 8 parts of rose, and 30 parts of Albizzia julibrissin bark.

[0045] Example 7

[0046] The difference between this embodiment and embodiment 1 is that the Chinese medicine composition is composed of the following raw materials in parts by weight: 43 parts of longan pulp, 22 parts of Poria cocos, 26 parts of Polygonatum sibiricum, 24 parts of tortoise shell, 40 parts of Codonopsis pilosula, 22 parts of yam, 30 parts of white hyacinth bean, 28 parts of jujube, 6 parts of Ganoderma lucidum, 4 parts of agarwood, 13 parts of Linderae serrata, 6 parts of rose, and 24 parts of Albizzia julibrissin bark.

[0047] Example 8

[0048] The difference between this embodiment and embodiment 1 is that the Chinese medicine composition is composed of the following raw materials in parts by weight: 22 parts of longan pulp, 12 parts of Poria cocos, 13 parts of Polygonatum sibiricum, 12 parts of tortoise shell, 22 parts of Codonopsis pilosula, 12 parts of yam, 16 parts of white hyacinth bean, 10 parts of jujube, 2 parts of Ganoderma lucidum, 1 part of agarwood, 6 parts of Linderae sibiricum, 2 parts of rose, and 11 parts of Albizzia julibrissin bark.

[0049] Example 9

[0050] The difference between this embodiment and embodiment 1 is that the Chinese medicine composition is composed of the following raw materials in parts by weight: 46 parts of longan pulp, 24 parts of Poria cocos, 28 parts of Polygonatum sibiricum, 26 parts of tortoise shell, 45 parts of Codonopsis pilosula, 24 parts of yam, 32 parts of white hyacinth bean, 30 parts of jujube, 7 parts of Ganoderma lucidum, 4 parts of agarwood, 14 parts of Linderae serrata, 7 parts of rose, and 28 parts of Albizzia julibrissin bark.

[0051] Test example

[0052] Typical clinical cases

[0053] The specific method of taking the Chinese medicine composition prepared according to the above Example 1 is: decoction, 1 dose / day, taken warm twice after meals, 14 doses as a course of treatment.

[0054] Case 1: Zhang, female, 60 years old. First visit on February 5, 2023. Main complaint: Involuntary spasm of both eyelids with frequent blinking and difficulty opening eyes for 3 months, symptoms relieved during sleep or dim light, Meige syndrome has been diagnosed in other hospitals, and symptoms have been relieved after local injection of botulinum toxin type A and taking benzhexol, but adverse reactions such as increased heart rate, constipation, blurred vision, etc. occurred during medication, and as time went on, the patient reported that the efficacy of subsequent treatment was not obvious, so the medication was stopped. The patient now reports that the above symptoms have worsened since the medication was stopped, the number of blinks has increased compared with before, the appetite is poor, insomnia and dreams, poor spirits, forgetfulness, irritability, irritability, pale and fat tongue, white and moist fur, and deep and thin pulse. TCM diagnosis: cell wheel vibration, dialectic: heart and spleen deficiency type. Comprehensive diagnosis of Meige syndrome of heart and spleen deficiency type. The patient began to take the above-mentioned Chinese medicine composition orally on May 16, 2023, one dose per day, twice a day after meals in the morning and evening, and took two courses of treatment.

[0055] Second visit on June 14, 2023: After taking the medicine, the patient felt that his eye spasms and blinking frequency decreased, and his memory improved. The patient was advised to continue taking 14 doses of the above-mentioned Chinese medicine combination, and add the Chinese patent medicine: Shugan Jieyu Capsules.

[0056] Third visit on June 29, 2023: After taking the medicine, the patient felt that his eye spasms and blinking frequency were significantly reduced, his diet, sleep, and mental state were significantly improved, his irritability and irritability disappeared, his tongue was normal, his tongue coating was slightly thick, and his pulse was deep. The patient was asked to continue taking 7 doses of the above-mentioned Chinese medicine combination.

[0057] Fourth visit on July 7, 2023: After taking the medicine, the patient felt that the symptoms of involuntary spasms in both eyes were significantly alleviated, the number of blinks was significantly reduced compared with before, and he still couldn't open his eyes when nervous and excited. His diet, sleep, and vision returned to normal, his mental state was good, his tongue was normal, his tongue coating was white, and his pulse was normal. The patient was asked to continue taking the above-mentioned Chinese medicine combination for two courses of treatment.

[0058] Two months later, the patient's eyelid spasm was not obvious. It occasionally occurred after emotional excitement, but it was within controllable range. The other symptoms returned to normal and did not recur. The patient was advised to pay attention to rest and diet. Six months later, the patient's eyelid spasm disappeared completely and did not recur.

[0059] Case 2: Sun, male, 54 years old. First visit on September 13, 2023. Chief complaint: Bilateral eyelid spasm gradually worsens for 1 year, accompanied by involuntary twitching of the corners of the mouth. In mid-2022, there was no obvious cause for eye discomfort, eyelid spasm and twitching of the corners of the mouth, especially when tired and emotional; the symptoms gradually worsened, and the number of bilateral eyelid spasms increased within half a year of onset. He was diagnosed with Meige syndrome in a hospital, and there was no significant improvement in symptoms after acupuncture treatment. The patient reported that he gradually developed symptoms such as unclear speech, difficulty swallowing, general appetite, forgetfulness and dreams, poor spirits, fatigue and weakness, abdominal distension, loose stools, pale and fat tongue, thick white fur, and weak pulse. Chinese medicine diagnosis: cell wheel vibration, dialectical: heart and spleen deficiency type. The comprehensive diagnosis is Meige syndrome of heart and spleen deficiency. The patient started taking the above-mentioned Chinese medicine combination on September 15, 2023, one dose per day, taken orally twice a day after meals, in the morning and evening, for two courses of treatment.

[0060] On October 14, 2023, the second visit showed that the patient felt that the spasm symptoms of both eyes were alleviated after taking the medicine, the number of twitching of the corners of the mouth decreased, the appetite and mental state were restored, the bowel movements returned to normal, the tongue was red, the tongue coating was slightly thick, and the pulse was stringy. The patient was advised to continue taking the above-mentioned Chinese medicine composition for one course of treatment.

[0061] On October 29, 2023, the patient was diagnosed with eye spasm after taking the medicine. The twitching of the corners of the mouth disappeared, the appetite and mental state returned to normal, the tongue was red with white fur, and the pulse was stringy. The patient was asked to continue taking the above-mentioned Chinese medicine composition for 7 days.

[0062] On November 7, 2023, the patient felt that the overall effect of the medication was obvious, the spasm symptoms of both eyes almost disappeared, and there were occasional attacks due to the environment, emotions, etc., swallowing was smooth, appetite and mental state were good, and bowel movements were normal without recurrence. The patient was advised to take the above-mentioned Chinese medicine combination urgently, two days / dose, warm after meals, to consolidate the efficacy of the medicine, and pay attention to rest and regulate emotions. Follow-up after half a year showed that the patient's symptoms in both eyes completely disappeared and did not recur.

[0063] Case 3: Wang, female, 43 years old. First visit on August 25, 2023. Chief complaint: Eyelid spasm in both eyes without obvious cause, accompanied by dry eyes, astringent eyes, and difficulty opening eyes. She went to a hospital outpatient clinic for treatment. The vision of both eyes was normal, and the eye fatigue test was negative. She was diagnosed with Meige syndrome. It was recommended that the patient refuse to inject type A botulinum toxin locally. Later, she took baclofen and methylcobalamin, but the symptoms did not improve significantly. After stopping the medication, the symptoms of both eyes persisted, affecting daily life and work. Current symptoms: obvious eyelid spasm in both eyes, accompanied by dry eyes, astringent eyes, difficulty opening eyes, dysphagia, irritability, loss of appetite, insomnia, pale and fat tongue, thick white fur, and deep and thin pulse. TCM diagnosis: cell wheel vibration, dialectical: heart and spleen deficiency type. Comprehensive diagnosis of Meige syndrome of heart and spleen deficiency type. The patient began to take the above-mentioned Chinese medicine composition on August 26, 2023, 1 dose / day, warm and taken twice a day after meals in the morning and evening, and took 2 courses of treatment.

[0064] Second visit on September 24, 2023: The patient felt that after taking the medicine, the symptoms of eyelid spasm and dry eyes were alleviated, appetite and sleep quality improved slightly, tongue was red, white fur was slightly thick, and pulse was stringy. The patient was advised to continue taking the above-mentioned Chinese medicine combination for one course of treatment.

[0065] Third visit on October 9, 2023: The patient felt that after taking the medicine, the symptoms of eyelid spasm in both eyes were significantly alleviated, the symptoms of dry eyes and astringent eyes disappeared, appetite and sleep returned to normal, mental state was good, irritability disappeared, tongue was red, tongue coating was white, and pulse was stringy. The patient was advised to continue taking the above Chinese medicine composition for 7 days.

[0066] Fourth visit on October 17, 2023: The patient reported that eyelid spasms in both eyes were not obvious, blinking and opening eyes were normal after relaxing and avoiding light, swallowing was smooth, appetite and sleep were normal, and mental state was good. The patient was advised to continue taking the above-mentioned Chinese medicine composition for two days / dose, warm after meals to consolidate the efficacy of the medicine, and pay attention to rest. Follow-up after half a year showed that the patient's symptoms in both eyes completely disappeared and there was no recurrence.

[0067] In summary, the Chinese medicine composition of the present invention takes tonifying the heart and spleen as the main therapeutic principle, has the effects of strengthening the spleen and eliminating dampness, calming the nerves, consolidating the essence and promoting the production of body fluid, promoting qi and relieving pain, and relieving asthma, and can significantly alleviate the symptoms of bilateral eyelid spasm, frequent blinking, dysphagia, insomnia and dreaminess in patients with heart and spleen deficiency type Meige syndrome, and has good therapeutic effect, no toxic side effects, and is not prone to recurrence, providing a new treatment idea for heart and spleen deficiency type Meige syndrome.

[0068] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit the same. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that the technical solutions described in the aforementioned embodiments may still be modified, or some of the technical features may be replaced by equivalents. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A Chinese medicine composition for treating Meige syndrome of heart and spleen deficiency type, characterized in that: The Chinese medicine composition is composed of the following raw materials in parts by weight: 20-50 parts of longan pulp, 10-25 parts of Poria cocos, 10-30 parts of polygonatum, 10-30 parts of tortoise shell, 20-50 parts of codonopsis pilosula, 10-30 parts of yam, 15-35 parts of white hyacinth bean, 6-36 parts of jujube, 1-8 parts of ganoderma lucidum, 1-5 parts of agarwood, 5-15 parts of lindera strychnifolia, 1-8 parts of rose, and 10-30 parts of julibrissin bark.

2. A Chinese medicine composition for treating Meige syndrome of heart and spleen deficiency type according to claim 1, characterized in that: The Chinese medicine composition is composed of the following raw materials in parts by weight: 30-45 parts of longan pulp, 15-20 parts of Poria cocos, 15-25 parts of Polygonatum sibiricum, 15-25 parts of tortoise shell, 30-40 parts of Codonopsis pilosula, 15-25 parts of yam, 20-30 parts of white hyacinth bean, 15-25 parts of jujube, 3-5 parts of Ganoderma lucidum, 1-3 parts of agarwood, 7-12 parts of Linderae serrata, 2-6 parts of rose, and 15-25 parts of Albizzia julibrissin bark.

3. A Chinese medicine composition for treating Meige syndrome of heart and spleen deficiency type according to claim 1, characterized in that: The Chinese medicine composition is composed of the following raw materials in parts by weight: 36 parts of longan pulp, 18 parts of Poria cocos, 22 parts of Polygonatum sibiricum, 20 parts of tortoise shell, 34 parts of Codonopsis pilosula, 18 parts of yam, 26 parts of white hyacinth bean, 20 parts of jujube, 4 parts of Ganoderma lucidum, 2 parts of agarwood, 10 parts of Linderae sibiricum, 5 parts of rose, and 18 parts of Albizzia julibrissin bark.

4. Use of the Chinese medicine composition according to any one of claims 1 to 3 in the preparation of a medicament for treating Meige syndrome of heart and spleen deficiency, characterized in that: The Chinese medicine composition is prepared into granules, powders, oral liquids, pills, decoctions or other pharmaceutically acceptable oral dosage forms by conventional pharmaceutical preparation methods and with medically acceptable adjuvants.