Anti-scrotum eczema foam aerosol as well as preparation method and application thereof

Abstract

The invention discloses an anti-scrotum eczema foam aerosol as well as a preparation method and application thereof. The anti-scrotum eczema foam aerosol is prepared from the following raw material components in percentage by weight: 20-30% of a traditional Chinese medicine composition, 8-12% of propane, 8-12% of butane, 3-5% of cocoanut fatty acid diethanolamide, 3-5% of sodium lauroyl sarcosinate, 1-2% of glycerol, 1-2% of propylene glycol and fatty alcohol-polyoxyethylene ether lt, 1%, lt of white oil; 1%, triethanolamine 1t; 0.5% of polyvinylpyrrolidone lt, and the balance of water; 0.5% of methyl chloride isothiazolinone lt; 0.5% of the raw materials, and 1t of deionized water; and 55%. The natural moisturizing balance of skin can be maintained, foam texture is fresh and cool and not greasy, normal respiratory metabolism of the skin is not affected, the skin is free of blocking feeling and slipping, normal touch feeling of the skin is not affected, the aerosol form is adopted, smearing is easy, medicine residues and discomfort can be reduced, and the skin care effect is good. The compliance of the patient can also be improved by using an odorless and quick-drying formula.

Description

Technical Field

[0001] The invention belongs to the technical field of anti-scrotal eczema, and particularly relates to an anti-scrotal eczema foam aerosol and a preparation method and application thereof. Background Art

[0002] Scrotal eczema is a common skin disease that mainly affects the male genital area, characterized by symptoms such as erythema, itching, dryness, scaling or exudation on the scrotal skin. Eczema is essentially a skin inflammation that may be related to a variety of factors such as allergies, irritation, infection, and immune response. Common causes of scrotal eczema mainly include allergic reactions, humid environments, friction irritation, infection, stress and anxiety.

[0003] The relief and treatment of scrotal eczema mainly include lifestyle and self-care, drug therapy, psychological adjustment and other aspects. For drug therapy, although some scrotal eczema treatment drugs currently on the market have certain clinical effects, there are still some defects and shortcomings: (1) Anti-scrotal eczema steroid ointment is a commonly used anti-inflammatory drug, but long-term or improper use may cause side effects such as skin thinning, pigmentation, and local infection; (2) Some anti-scrotal eczema drugs may not be suitable for some patients, especially those with sensitive skin or allergic constitution, and may cause additional allergic or irritation reactions; (3) Some drug forms (such as thick ointments) may not be convenient when applied, especially in hot and humid environments, which may aggravate discomfort. In addition, after application, it may affect daily activities, such as sticky feeling, odor, etc. In addition, antifungal drugs may cause skin irritation or allergic reactions. Therefore, in view of the above problems, the anti-scrotal eczema foam aerosol provided by the present invention and its preparation method and application are of great significance. Summary of the invention

[0004] The present invention provides an anti-scrotal eczema foam aerosol and a preparation method and application thereof, which can maintain the natural moisture balance of the skin, and the foam has a refreshing texture and is not greasy, and does not affect the normal respiratory metabolism of the skin; the skin has no occlusive feeling, does not slip, and does not affect the normal touch of the skin; by adopting the form of aerosol, it is not only easy to apply, but also can reduce drug residues and discomfort, and the use of an odorless, quick-drying formula can also improve patient compliance, and in summary, the problems in the background technology are solved.

[0005] In order to solve the above technical problems, the present invention is achieved through the following technical solutions:

[0006] The invention discloses an anti-scrotal eczema foam aerosol, which is prepared by the following raw material components in weight percentage: 20-30% of a Chinese medicine combination (composed of 10 parts of Phellodendron amurense, 10 parts of Sophora flavescens, 15 parts of Cnidium monnieri, 10 parts of Galla chinensis, 10 parts of Licorice, and 0.5 part of Borneolum), 8-12% of propane, 8-12% of butane, 3-5% of coconut oil fatty acid diethanolamide, 3-5% of sodium lauroyl sarcosinate, 1-2% of glycerol, 1-2% of propylene glycol, less than 1% of fatty alcohol polyoxyethylene ether, less than 1% of white oil, less than 0.5% of triethanolamine, less than 0.5% of polyvinyl pyrrolidone, less than 0.5% of methylchloroisothiazolinone, and less than 55% of deionized water;

[0007] The Chinese medicine combination specifically includes the following Chinese medicine components in parts by weight: 10 parts of Phellodendron amurense, 10 parts of Sophora flavescens, 15 parts of Cnidium monnieri, 10 parts of Galla chinensis, 10 parts of Licorice root and 0.5 parts of Borneol.

[0008] Furthermore, the specific dosage of various raw material ingredients is: 25% of Chinese medicine combination, 10% of propane, 10% of butane, 4% of coconut oil fatty acid diethanolamide, 4% of sodium lauroyl sarcosinate, 1.5% of glycerol, 1.5% of propylene glycol, 0.5% of fatty alcohol polyoxyethylene ether, 0.5% of white oil, 0.4% of triethanolamine, 0.3% of polyvinyl pyrrolidone, 0.3% of methylchloroisothiazolinone, and 42% of deionized water.

[0009] Furthermore, for the solid raw material components, impurities are first picked out, mud and sand are sieved out, and after washing and drying, they are chopped and ground into powder, and then sterilized by sterilizing equipment such as sterile filters to remove residual pathogens or microbial contamination on the surface of the raw material powder.

[0010] Furthermore, the following preparation equipment is included: 1 1-ton scraping stirring reactor, 1 aerosol fully automatic production line, 3 1kg electronic scales, 1 300kg electronic scale, 1 2-ton electronic scale, 2 1-ton manual forklifts, 1 1-ton electric forklift, 1 3-ton driving electric forklift, and 15-25 100kg stationary plastics.

[0011] Furthermore, the aerosol fully automatic production line in the preparation equipment specifically includes 1 4-head filling machine, 1 valve installing machine, 1 valve sealing machine, 1 2-head inflating machine, 1 nozzle installing machine, 1 inkjet printer, and 1 carton sealing machine.

[0012] Furthermore, the preparation process includes the following: raw material mixing and stirring, emulsification and foaming, filling, sealing, inflation, nozzle installation and cover, coding, boxing, and warehousing.

[0013] Furthermore, for the mixing and stirring of raw materials in the preparation process, after ensuring that all raw materials are completely dissolved and a suspension is formed, stirring is performed for 30 minutes until the suspension is uniformly mixed.

[0014] A preparation method and application of an anti-scrotal eczema foam aerosol, which is achieved by using the above-mentioned anti-scrotal eczema foam aerosol, comprises the following steps:

[0015] S1. After all the raw materials are completely dissolved and a suspension is formed by scraping the wall of the stirring reactor, the suspension is stirred for 30 minutes until the suspension is evenly mixed;

[0016] S2. Fill the mixed and stirred pharmaceutical suspension into a special aerosol can under sterile conditions through a 4-head filling machine, and then seal the aerosol can through a valve installation machine and a valve sealing machine. After sealing, perform a leak test on the aerosol can to ensure good sealing;

[0017] S3. Injecting an appropriate amount of foaming gas, such as nitrogen or carbon dioxide, into the aerosol can through an inflator to ensure that the aerosol can produce uniform foam when used;

[0018] S4. Install the spray head on the aerosol can by using a spray head installation machine and cover it with a matching cap;

[0019] S5. Spray a code on the aerosol can by using a printer, so as to indicate the usage, precautions and validity period of the foam aerosol by the code;

[0020] S6. The aerosol cans are packed into boxes in batches by a box sealing machine and transported to the corresponding warehouse for storage. The warehouse environment should be kept cool and dry to avoid high temperature and direct sunlight;

[0021] An application of an anti-scrotal eczema foam aerosol, spraying the anti-scrotal eczema foam aerosol on the scrotal eczema site.

[0022] Compared with the prior art, the present invention has the following beneficial effects:

[0023] (1) The anti-scrotal eczema foam aerosol of the present invention can maintain the natural moisture balance of the skin, and the foam has a refreshing texture and is not greasy, and does not affect the normal respiratory metabolism of the skin;

[0024] (2) The anti-scrotal eczema foam aerosol of the present invention does not cause the skin to feel blocked or slippery, and does not affect the normal touch of the skin;

[0025] (3) The anti-scrotal eczema foam aerosol of the present invention is in the form of an aerosol, which is not only easy to apply, but also can reduce drug residue and discomfort. The use of an odorless and quick-drying formula can also improve patient compliance.

[0026] Of course, any product implementing the present invention does not necessarily need to achieve all of the advantages described above at the same time. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings required for describing the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other accompanying drawings can be obtained based on these accompanying drawings without paying creative work.

[0028] Figure 1 The present invention is a process flow chart of an anti-scrotal eczema foam aerosol and its preparation method and application. DETAILED DESCRIPTION

[0029] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0030] In the description of the present invention, it should be understood that the terms "relative", "one end", "inside", "lateral", "end", "two ends", "both sides", "front", "one end face", "the other end face" and the like indicating orientation or positional relationship are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the components or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the present invention.

[0031] The invention discloses an anti-scrotal eczema foam aerosol, which is prepared by the following raw material components in proportion by weight: 20-30% of a Chinese medicine combination (composed of 10 parts of Phellodendron amurense, 10 parts of Sophora flavescens, 15 parts of Cnidium monnieri, 10 parts of Galla chinensis, 10 parts of Licorice, and 0.5 part of Borneolum Syntheticum), 8-12% of propane, 8-12% of butane, 3-5% of coconut oil fatty acid diethanolamide, 3-5% of sodium lauroyl sarcosinate, 1-2% of glycerol, 1-2% of propylene glycol, less than 1% of fatty alcohol polyoxyethylene ether, less than 1% of white oil, less than 0.5% of triethanolamine, less than 0.5% of polyvinyl pyrrolidone, less than 0.5% of methylchloroisothiazolinone, and less than 55% of deionized water; the Chinese medicine combination specifically comprises the following Chinese medicine components in proportion by weight: 10 parts of Phellodendron amurense, 10 parts of Sophora flavescens, 15 parts of Cnidium monnieri, 10 parts of Galla chinensis, 10 parts of Licorice, and 0.5 part of Borneolum Syntheticum.

[0032] Among them, the specific dosage of various raw material ingredients is: 25% of traditional Chinese medicine combination, 10% of propane, 10% of butane, 4% of coconut oil fatty acid diethanolamide, 4% of sodium lauroyl sarcosinate, 1.5% of glycerol, 1.5% of propylene glycol, 0.5% of fatty alcohol polyoxyethylene ether, 0.5% of white oil, 0.4% of triethanolamine, 0.3% of polyvinyl pyrrolidone, 0.3% of methylchloroisothiazolinone, and 42% of deionized water.

[0033] Among them, for the solid raw material components, first pick out impurities, sieve out mud and sand, wash and dry them, then chop and grind them into powder, and then pass them through sterilization equipment such as sterile filters to remove pathogens or microbial contamination remaining on the surface of the raw material powder.

[0034] Among them, the following preparation equipment are included: 1 1-ton scraping stirring reactor, 1 aerosol fully automatic production line, 3 1kg electronic scales, 1 300kg electronic scale, 1 2-ton electronic scale, 2 1-ton manual forklifts, 1 1-ton electric forklift, 1 3-ton driving electric forklift, and 15-25 100kg stationary plastics.

[0035] Among them, the aerosol fully automatic production line in the preparation equipment specifically includes 1 4-head filling machine, 1 valve installing machine, 1 valve sealing machine, 1 2-head inflating machine, 1 nozzle installing machine, 1 inkjet printer, and 1 carton sealing machine.

[0036] Among them, the following preparation processes are included: raw material mixing and stirring, emulsification and foaming, filling, sealing, inflation, installing nozzles and caps, coding, packing, and warehousing.

[0037] Among them, for the mixing and stirring of raw materials in the preparation process, after ensuring that all raw materials are completely dissolved and form a suspension, stir for 30 minutes until the suspension is uniformly mixed.

[0038] See also Figure 1 As shown, a method for preparing an anti-scrotal eczema foam aerosol is implemented using the above-mentioned anti-scrotal eczema foam aerosol, comprising the following steps:

[0039] S1. After all the raw materials are completely dissolved and a suspension is formed by scraping the wall of the stirring reactor, the suspension is stirred for 30 minutes until the suspension is evenly mixed;

[0040] S2. Fill the mixed and stirred pharmaceutical suspension into a special aerosol can under sterile conditions through a 4-head filling machine, and then seal the aerosol can through a valve installation machine and a valve sealing machine. After sealing, perform a leak test on the aerosol can to ensure good sealing;

[0041] S3. Injecting an appropriate amount of foaming gas, such as nitrogen or carbon dioxide, into the aerosol can through an inflator to ensure that the aerosol can produce uniform foam when used;

[0042] S4. Install the spray head on the aerosol can by using a spray head installation machine and cover it with a matching cap;

[0043] S5. Spray a code on the aerosol can by using a printer, so as to indicate the usage, precautions and validity period of the foam aerosol by the code;

[0044] S6. The aerosol cans are packed in batches into boxes using a carton sealing machine and transported to the corresponding warehouse for storage. The warehouse environment should be kept cool and dry to avoid high temperatures and direct sunlight.

[0045] The working principle of the present invention is:

[0046] The present invention cleans and dries the skin when in use, shakes the bottle body several times up and down, then the bottle mouth faces downward, and the foam can be seen by pressing the valve lightly. The pressing amount can be as needed each time. The product has good ductility. Generally, the foam amount of a walnut size can cover both sides of both hands. Rub carefully, pay attention to the skin wrinkles, and the nail edge needs to be evenly applied. After 3 minutes, the skin protective layer can be formed, even if the skin needs to contact water or solution for many times, there is at least 4 hours of skin protection, and there is no need to apply emollient again during this period. This product can be used all over the body, including the face. The product of the present invention has the effects of dispelling wind and relieving itching, clearing away heat and detoxifying, and astringing sores and promoting tissue regeneration, and can play the role of resisting scrotal eczema. Compared with traditional scrotal eczema treatment drugs, it can not only maintain the natural water balance of the skin, but also the foam texture is refreshing, not greasy, does not affect the normal respiratory metabolism of the skin, and the skin has no sense of occlusion, does not slip, and does not affect the normal touch of the skin. In addition, by adopting the form of aerosol, it is not only easy to apply, but also can reduce drug residues and discomfort, and the use of odorless, quick-drying formula can also improve the compliance of patients.

[0047] The preferred embodiments of the present invention disclosed above are only used to help illustrate the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to the specific implementation methods described. Obviously, many modifications and changes can be made according to the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the present invention, so that those skilled in the art can understand and use the present invention well. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. An anti-scrotal eczema foam aerosol, characterized in that: The Chinese medicine composition is composed of the following raw material ingredients in weight percentage: 20-30% of Chinese medicine combination, 8-12% of propane, 8-12% of butane, 3-5% of coconut oil fatty acid diethanolamide, 3-5% of sodium lauroyl sarcosinate, 1-2% of glycerol, 1-2% of propylene glycol, <1% of fatty alcohol polyoxyethylene ether, <1% of white oil, <0.5% of triethanolamine, <0.5% of polyvinyl pyrrolidone, <0.5% of methylchloroisothiazolinone, and <55% of deionized water; the Chinese medicine combination specifically includes the following Chinese medicines in weight percentage: Composition: 10 parts of Phellodendron chinense, 10 parts of Sophora flavescens, 15 parts of Cnidium monnieri, 10 parts of Galla chinensis, 10 parts of Licorice and 0.5 parts of Borneol.

2. The anti-scrotal eczema foam aerosol according to claim 1, characterized in that: The specific dosage of various raw materials is: 25% of Chinese medicine combination, 10% of propane, 10% of butane, 4% of coconut oil fatty acid diethanolamide, 4% of sodium lauroyl sarcosinate, 1.5% of glycerol, 1.5% of propylene glycol, 0.5% of fatty alcohol polyoxyethylene ether, 0.5% of white oil, 0.4% of triethanolamine, 0.3% of polyvinyl pyrrolidone, 0.3% of methylchloroisothiazolinone, and 42% of deionized water.

3. The anti-scrotal eczema foam aerosol according to claim 1, characterized in that: For solid raw material ingredients, first pick out impurities, sieve out mud and sand, wash and dry them, then chop and grind them into powder, and then pass them through sterilization equipment such as sterile filters to remove pathogens or microbial contamination remaining on the surface of the raw material powder.

4. The anti-scrotal eczema foam aerosol according to claim 1, characterized in that: It includes the following preparation equipment: 1 1-ton scraping stirring reactor, 1 aerosol fully automatic production line, 3 1kg electronic scales, 1 300kg electronic scale, 1 2-ton electronic scale, 2 1-ton manual forklifts, 1 1-ton electric forklift, 1 3-ton driving electric forklift, and 15-25 100kg stationary plastics.

5. The anti-scrotal eczema foam aerosol according to claim 3, characterized in that: For the aerosol fully automatic production line in the preparation equipment, it specifically includes 1 4-head filling machine, 1 valve installing machine, 1 valve sealing machine, 1 2-head inflating machine, 1 nozzle installing machine, 1 inkjet printer, and 1 carton sealing machine.

6. The anti-scrotal eczema foam aerosol according to claim 1, characterized in that: The preparation process includes: raw material mixing and stirring, filling, sealing, aeration, nozzle installation and capping, coding, boxing and warehousing.

7. The anti-scrotal eczema foam aerosol according to claim 6, characterized in that: For the mixing and stirring of raw materials in the preparation process, after ensuring that all raw materials are completely dissolved and a suspension is formed, stirring is continued for 30 minutes until the suspension is uniformly mixed.

8. A method for preparing an anti-scrotal eczema foam aerosol, characterized in that: The method for preparing an anti-scrotal eczema foam aerosol according to any one of claims 1 to 7 comprises the following steps: S1. After all the raw materials are completely dissolved and a suspension is formed by scraping the wall of the stirring reactor, the suspension is stirred for 30 minutes until the suspension is evenly mixed; S2. Fill the mixed and stirred pharmaceutical suspension into a special aerosol can under sterile conditions through a 4-head filling machine, and then seal the aerosol can through a valve installation machine and a valve sealing machine. After sealing, perform a leak test on the aerosol can to ensure good sealing; S3. Injecting an appropriate amount of foaming gas, such as nitrogen or carbon dioxide, into the aerosol can through an inflator to ensure that the aerosol can produce uniform foam when used; S4. Install the spray head on the aerosol can by using a spray head installation machine and cover it with a matching cap; S5. Spray a code on the aerosol can by using a printer, so as to indicate the usage, precautions and validity period of the foam aerosol by the code; S6. The aerosol cans are packed in batches into boxes using a carton sealing machine and transported to the corresponding warehouse for storage. The warehouse environment should be kept cool and dry to avoid high temperatures and direct sunlight.

9. An application of an anti-scrotal eczema foam aerosol, characterized in that: Spray the anti-scrotal eczema foam aerosol as described in any one of claims 1 to 7 onto the scrotal eczema site.

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