Coherent anti-stokes raman microscopy system, its driving method and microscopy apparatus

By employing self-phase modulation spectral selection (SESS) and second harmonic generation methods, the problems of low wavelength conversion efficiency and limited pulse energy in CARS imaging have been solved, achieving high signal-to-noise ratio and selective imaging, applicable to imaging of various biological tissue components.

CN119394998BActive Publication Date: 2026-06-19INSTITUTE OF PHYSICS CHINESE ACADEMY OF SCIENCES
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Patent Information

Application Number
CN202411677813.4
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-11-22
Publication Date
2026-06-19
Estimated Expiration
2044-11-22

AI Technical Summary

Technical Problem

In existing CARS imaging technologies, wavelength conversion technology has low conversion efficiency and is sensitive to environmental fluctuations, and pulse energy is limited, making it difficult to achieve high signal-to-noise ratio and selective imaging.

Method used

The CARS system is driven by an ultrafast fiber laser source with self-phase modulation spectral selection (SESS) and second harmonic generation, using a dual-wavelength system. Through a femtosecond laser front-end module, a dual-wavelength module, a pulse broadening and amplification module, a time delay module, a spectral broadening and filtering module, a second harmonic generation module, and a dispersion compensation module, high conversion efficiency and compressible pulse width are achieved.

Benefits of technology

It achieves high conversion efficiency and pulse width compressible pulse output, improving the signal-to-noise ratio and selectivity of CARS imaging, and is suitable for selective imaging of various biological tissue components.

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Abstract

This invention provides a coherent anti-Stokes Raman microscope system, its driving method, and its microscopic apparatus. The coherent anti-Stokes Raman microscope system includes: a femtosecond laser front-end module, a dual-wavelength module, a pulse broadening and amplification module, a time delay module, a spectral broadening and filtering module, a second harmonic generation module, a dispersion compensation module, and a microscope module. The self-phase modulation spectral selection (SESS) driven coherent anti-Stokes Raman microscope system of this invention uses a self-phase modulation spectral selection (SESS) method to convert a 1550 nm pulse wavelength to 1600 nm. Through a frequency doubling crystal, a second harmonic generation process is achieved, converting the 1600 nm pulse wavelength to 800 nm, thus realizing coherent anti-Stokes Raman microscopy imaging, i.e., selective imaging of various biological tissue components. Compared with other wavelength conversion methods, the device is simple, has high conversion efficiency, is tunable, and has strong scalability.
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