Preparation method of medicinal external washing powder for treating migraine

Abstract

The invention relates to the field of migraine treatment, and discloses a preparation method of medicinal external washing powder for treating migraine, the medicinal external washing powder is prepared from the following raw material medicines by weight: 15-20 g of gastrodia elata, 10-15 g of ligusticum wallichii, 6-8 g of angelica dahurica, 7-9 g of notopterygium root, 11-14 g of divaricate saposhnikovia root, 3-5 g of asarum, 12-16 g of ginger, 14-17 g of folium artemisiae argyi, and 13-15 g of schizonepeta. The traditional Chinese medicine has the functions of tonifying spleen, harmonizing stomach, calming heart and tranquilizing mind, and has the advantages of quick response, short treatment course, no relapse and high cure rate when being used for treating migraine.

Description

Technical Field

[0001] The invention relates to the field of migraine treatment, in particular to a method for preparing a medicinal external wash powder for treating migraine. Background Art

[0002] Migraine is the most common type of primary headache in clinic. The main clinical manifestation is paroxysmal moderate to severe, throbbing headache. The headache is mostly on one side. Migraine is a recurrent throbbing headache and is a "big player" among many types of headaches. It often has precursors such as flashes, blurred vision, and limb numbness before the onset of the disease. Throbbing pain on one side of the head occurs for about a few minutes to an hour and gradually intensifies until nausea and vomiting occur. The feeling will not improve until in a quiet, dark environment or after sleep. Neurological and mental dysfunction may occur before or during the onset of headaches.

[0003] In the prior art, in the migraine treatment drug with announcement number CN1444942A, the application uses ibuprofen and western medicine containing caffeine to treat patients' migraine, or uses analgesics and tranquilizers to relieve pain, but western medicine has great side effects and is likely to cause adverse reactions in patients. Therefore, we provide a method for preparing a medicinal external wash powder for treating migraine. Summary of the invention

[0004] 1. Technical issues to be resolved

[0005] In view of the deficiencies in the prior art, the present invention provides a method for preparing a medicinal external wash powder for treating migraine, which has the advantages of rapid effect in treating migraine, short treatment course, no recurrence, and high cure rate, and solves the problems in the above-mentioned background technology.

[0006] (II) Technical solution

[0007] In order to achieve the above-mentioned purpose of treating migraine with rapid effect, short treatment course, no recurrence and high cure rate, the present invention provides the following technical scheme: a method for preparing a medicinal external wash powder for treating migraine, which is made from the following raw materials in parts by weight: 15-20 grams of Gastrodia elata, 10-15 grams of Chuanxiong, 6-8 grams of Angelica dahurica, 7-9 grams of Notopterygium wilfordii, 11-14 grams of Saposhnikovia divaricata, 3-5 grams of Asarum, 12-16 grams of ginger, 14-17 grams of Artemisia argyi and 13-15 grams of Schizonepeta tenuifolia.

[0008] A method for preparing a medicinal external wash powder for treating migraine, which is specifically made from the following raw materials in parts by weight: 17 grams of Gastrodia elata, 12 grams of Chuanxiong, 7 grams of Angelica dahurica, 8 grams of Notopterygium wilfordii, 13 grams of Saposhnikovia divaricata, 4 grams of Asarum, 14 grams of ginger, 15 grams of Artemisia argyi, and 14 grams of Schizonepeta tenuifolia.

[0009] A method for preparing a medicinal external wash powder for treating migraine comprises the following steps:

[0010] S1: Select and weigh in order according to weight, such as Chuanxiong, Angelica dahurica, Notopterygium wilfordii, Saposhnikovia divaricata, and Asarum, wash, cut, and dry;

[0011] Preferably, S1 further includes selecting and weighing Chinese medicinal materials, such as Chuanxiong, Angelica dahurica, Notopterygium wilfordii, Saposhnikovia divaricata, and Asarum, firstly accurately weighing these medicinal materials according to the weight required by the formula, then washing them with clean water to remove dust and impurities on the surface, and then cutting the medicinal materials into small pieces or small pieces, and the cut medicinal materials need to be dried in a well-ventilated and cool place.

[0012] S2: Put the dried medicinal materials into a grinder and grind them into fine powder;

[0013] S3: Use a sieve to sift the powder to remove coarse particles;

[0014] Preferably, S3 further includes pouring the crushed medicinal powder into a fine sieve, selecting the size of the sieve holes, and then gently tapping the edge of the sieve to allow the fine powder to gradually pass through the sieve holes and fall into a clean container. After the screening is completed, the coarse particles remaining on the sieve are collected, crushed again, and re-sieved until all the medicinal powders reach the required uniform fineness.

[0015] S4: Mix different medicinal powders evenly according to proportion;

[0016] Preferably, S4 further includes weighing the sieved medicinal powders according to the formula ratio, and then pouring the powders into a large, static-free mixing container in turn, using a dry, clean stirring tool, paying attention to the stirring strength and uniformity during mixing, and continuously stirring to take out some of the mixed medicinal powders for visual inspection. During the mixing process, ensure that the environment is dry.

[0017] S5: Put the mixed powder into a dry, sealed container and store it in a cool and dry place;

[0018] S6: Take the powder as needed, mix it with warm water, and wash the affected area or apply it with a wet cloth.

[0019] Preferably, S6 further includes taking out the medicine powder, usually 20-30 grams, pouring it into a clean bowl, then pouring in 500 ml of warm water, and stirring it thoroughly with a clean spoon until the medicine powder is completely dissolved to form a medicine liquid. If the affected area is washed externally, pour the medicine liquid into a washbasin or a large bowl, and the patient can gently wipe the affected area with a towel dipped in the medicine liquid, or directly soak the affected area in the medicine liquid for 15-20 minutes. If used for applying a wet cloth to the affected area, dip a clean cotton cloth or gauze into the medicine liquid, take it out after full absorption, gently wring it until no water drips, and then apply it to the affected area for 20-30 minutes. It can be covered with plastic wrap during this period. After use, it can be repeatedly applied as needed. It is recommended to apply 1-2 times a day until the symptoms are relieved.

[0020] (III) Beneficial effects

[0021] Compared with the prior art, the present invention provides a method for preparing a medicinal external wash powder for treating migraine, which has the following beneficial effects:

[0022] The present invention selects and weighs Chinese medicinal materials, such as Gastrodia elata, Chuanxiong, Angelica dahurica, Saposhnikovia divaricata, and Asarum, washes, cuts, and dries, and the dried medicinal materials are put into a grinder to be pulverized into fine powder; Gastrodia elata has the effects of calming the liver, extinguishing wind, and stopping spasms, and is commonly used to treat symptoms such as headache, dizziness, and numbness of limbs. In Yao medicine, Gastrodia elata is also considered to have a good therapeutic effect on headache, and Chuanxiong is known as the "blood Qi medicine", which has the effects of promoting blood circulation and qi, dispelling wind and relieving pain. It is often used to treat various headaches, including migraine, and can effectively relieve headache symptoms. Angelica dahurica has the effects of dispelling wind and cold, clearing the orifices and relieving pain, and has significant therapeutic effects on symptoms such as wind-cold headache and brow pain. In Yao medicine, Angelica dahurica is also used to treat headache-related diseases, and Saposhnikovia divaricata has the effects of dispelling wind and relieving exterior symptoms, overcoming dampness and relieving pain, and is commonly used to treat headaches caused by exogenous wind-cold. Although Fangfeng is not directly targeted at migraines, its wind-dispelling and pain-relieving effects can help relieve some of the symptoms of migraines. Asarum has the effects of dispelling wind and cold, opening the orifices and relieving pain, and has a good effect on symptoms such as wind-cold headaches and toothaches. In Yao medicine, Asarum may also be used to treat symptoms related to headaches. Use a sieve to screen the powder to remove coarse particles to make the powder more uniform and delicate; mix different medicinal powders in proportion to ensure the uniform distribution of each component in each powder; put the mixed powder into a dry, sealed container and store it in a cool and dry place to avoid moisture and direct sunlight. It has the advantages of fast treatment, short course of treatment, no recurrence, and high cure rate. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 Schematic diagram of the method of the present invention. DETAILED DESCRIPTION

[0024] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0025] Embodiment 1:

[0026] The invention provides a technical solution: a method for preparing a medicinal external wash powder for treating migraine, which is prepared from the following raw materials in parts by weight: 15-20 grams of gastrodia elata, 10-15 grams of chuanxiong, 6-8 grams of angelica dahurica, 7-9 grams of notopterygium root, 11-14 grams of siler, 3-5 grams of asarum, 12-16 grams of ginger, 14-17 grams of wormwood leaf, and 13-15 grams of schizonepeta tenuifolia.

[0027] A method for preparing a medicinal external wash powder for treating migraine comprises the following steps:

[0028] S1: Select and weigh Chinese medicinal materials, such as Gastrodia elata, Chuanxiong, Angelica dahurica, Notopterygium wilfordii, Saposhnikovia divaricata, and Asarum, wash, cut, and dry;

[0029] Select and weigh Chinese medicinal materials, such as Chuanxiong, Angelica dahurica, Notopterygium wilfordii, Saposhnikovia divaricata, and Asarum. First, accurately weigh these medicinal materials according to the weight required by the formula, then wash them with clean water to remove surface dust and impurities, and then cut the medicinal materials into small pieces or small pieces for subsequent processing. The cut medicinal materials need to be dried in a well-ventilated and cool place, or use low-temperature drying method to make them fully dry to ensure that there is no moisture residue inside and outside the medicinal materials for subsequent crushing and preparation.

[0030] S2: Put the dried medicinal materials into a grinder and grind them into fine powder;

[0031] Put the dried medicinal materials into the grinder one by one, select the appropriate grinding time and speed, and grind the medicinal materials into fine and uniform powder. During the grinding process, attention should be paid to controlling the grinding time and avoiding overheating to prevent damage to the medicinal ingredients. The ground medicinal powder can be sieved once to remove coarser particles to ensure that the final medicinal powder is fine and smooth for easy mixing and use.

[0032] S3: Use a sieve to sift the powder to remove coarse particles;

[0033] Pour the crushed powder into a fine sieve, select the appropriate sieve hole size, then gently tap the edge of the sieve or use a scraper to gently push on the surface of the sieve to allow the fine powder to gradually pass through the sieve holes and fall into a clean container. During the process, make sure the sieve is always level and avoid excessive force to prevent the powder from getting damp or agglomerating. After screening, collect the coarse particles remaining on the sieve, crush them again and re-sieve them until all the powder reaches the required uniform fineness. This step not only removes coarse particles, but also makes the powder more uniform, ensuring its effectiveness and consistency in subsequent use.

[0034] S4: Mix different medicinal powders evenly according to proportion;

[0035] Weigh the sieved medicinal powders according to the formula ratio, and then pour the powders into a large, static-free mixing container in turn. Use a dry, clean stirring tool, or seal the container and gently shake or roll it to ensure that the powders are fully mixed in the container. When mixing, pay attention to the intensity and uniformity of stirring to prevent the powder from flying or static electricity from adsorbing on the container wall. After continuous stirring or shaking for a few minutes, take out some mixed powder for visual inspection or simple testing to confirm that the ingredients are evenly distributed. During the mixing process, ensure that the environment is dry to prevent the powder from getting damp and clumping, which will affect the efficacy and quality.

[0036] S5: Put the mixed powder into a dry, sealed container and store it in a cool and dry place;

[0037] Carefully pour the mixed powder into a dry, clean, sealed container, making sure that there is no moisture or impurities inside the container. Close the container lid tightly to prevent air from entering. Mark the name, formula ratio, production date and other information of the powder on the outside of the container for easy management and use. Then, store the container in a cool, dry place away from direct sunlight and high temperature to prevent the powder from getting damp or reducing its efficacy. Make sure the storage environment is well ventilated to keep the powder dry and stable.

[0038] S6: Take an appropriate amount of powder as needed, mix with warm water, and wash the affected area or apply a wet cloth to the affected area.

[0039] As needed, take out an appropriate amount of powder, usually 20-30 grams, pour it into a clean bowl, then pour in 500 ml of warm water, stir thoroughly with a clean spoon until the powder is completely dissolved to form a uniform liquid medicine. If it is for external washing of the affected area, pour the liquid medicine into a washbasin or a large bowl. The patient can dip a towel in the liquid medicine and gently wipe the affected area, or directly soak the affected area in the liquid medicine for 15-20 minutes. If used for applying a wet cloth to the affected area, dip a clean cotton cloth or gauze in the liquid medicine, take it out after full absorption, gently wring it until no water drips, and then apply it to the affected area for 20-30 minutes. During this period, it can be covered with plastic wrap to keep it moist. After use, it can be repeated as needed. It is recommended to apply 1-2 times a day until the symptoms are relieved.

[0040] To prove that the present invention has good curative effect, typical cases are listed as follows:

[0041] Case 1:

[0042] Wang, female, 45 years old, experiences migraine for more than 15 days a month, accompanied by photosensitivity and nausea during attacks, which seriously affects her daily life. Her headache is usually unilateral and pulsating, and lasts for up to 72 hours. The headache can be relieved after taking analgesics, but it only treats the symptoms and not the root cause. After three days of treatment with the Chinese medicine of the present invention, the number of headaches was significantly reduced, and the patient was cured after one week.

[0043] The traditional Chinese medicine for treating migraine is prepared from the following raw materials by weight: 16 grams of gastrodia elata, 11 grams of chuanxiong, 7 grams of angelica dahurica, 8 grams of notopterygium wilfordii, 12 grams of siler and 4 grams of asarum.

[0044] Preparation method: add 6 times the amount of water to the above weight of Gastrodia elata, Chuanxiong, Angelica dahurica, Notopterygium wilfordii, Saposhnikovia divaricata, and Asarum, boil over high heat for 25 minutes, then add 4 times the amount of water, and boil over low heat for 20 minutes to obtain the medicinal liquid, which can be divided into 4 doses.

[0045] Dosage and administration: Oral, three times a day.

[0046] Case 2:

[0047] Zhang, male, 28 years old, often has visual auras before migraine attacks, such as flashes, jagged lights in the visual field or blurred vision. The auras usually last for 20-30 minutes, followed by severe, throbbing pain on one side of the head, accompanied by nausea and sensitivity to light and sound. The attacks usually last for 4-72 hours. After one week of treatment with the Chinese medicine of the present invention, the nausea symptoms disappeared. After two weeks, the patient recovered and there was no recurrence during follow-up.

[0048] The traditional Chinese medicine for treating migraine is prepared from the following raw materials by weight: 17 grams of gastrodia elata, 12 grams of chuanxiong, 8 grams of angelica dahurica, 9 grams of notopterygium wilfordii, 13 grams of siler and 5 grams of asarum.

[0049] Preparation method: add 6 times the amount of water to the above weight of Gastrodia elata, Chuanxiong, Angelica dahurica, Notopterygium wilfordii, Saposhnikovia divaricata, and Asarum, boil over high heat for 25 minutes, then add 4 times the amount of water, and boil over low heat for 20 minutes to obtain the medicinal liquid, which can be divided into 4 doses.

[0050] Dosage and administration: Oral, three times a day.

[0051] Case 3:

[0052] Ms. Li, 30 years old, had headache for six months. When under great pressure at work, she often felt tight pain on both sides of the head, accompanied by stiffness and tension in the shoulders and neck, which lasted from several hours to several days. After five days of treatment with the Chinese medicine of the present invention, the stiffness in the shoulders and neck disappeared, and after ten days, the patient recovered.

[0053] The traditional Chinese medicine for treating migraine is prepared from the following raw materials by weight: 18 grams of gastrodia elata, 13 grams of chuanxiong, 6 grams of angelica dahurica, 7 grams of notopterygium wilfordii, 14 grams of siler and 3 grams of asarum.

[0054] Preparation method: add 6 times the amount of water to the above weight of Gastrodia elata, Chuanxiong, Angelica dahurica, Notopterygium wilfordii, Saposhnikovia divaricata, and Asarum, boil over high heat for 25 minutes, then add 4 times the amount of water, and boil over low heat for 20 minutes to obtain the medicinal liquid, which can be divided into 4 doses.

[0055] Dosage and administration: Oral, three times a day.

[0056] Example 2: Animal toxicity test report of the drug of the present invention

[0057] Twenty rabbits, both male and female, weighing 1.5-2.0kg, were taken and divided into two groups, 10 in each group. One group was the overdose test group, and the other was the normal dose test group. The overdose group was given 0.4 grams per rabbit each time, and the normal dose was 0.2 grams per rabbit each time. The administration method was diluted gavage, three times a day, for 7 consecutive days. The drug reaction was observed every day. The results showed that the activities and diet of the two groups of rabbits were normal, and the drug had no adverse toxic side effects.

[0058] Example 3: Observation of clinical efficacy of the drug of the present invention

[0059] 1. A total of 20 patients with migraine were admitted to the outpatient clinic.

[0060] 2. The main clinical manifestation of migraine is paroxysmal moderate to severe, throbbing headaches. The headaches are mostly unilateral and generally last for 4 to 72 hours. They may be accompanied by nausea and vomiting. Light, sound stimulation or daily activities can aggravate the headaches.

[0061] 3. Choose the above-mentioned medicine and give it to the patient, 1 dose each time, 2 pills each time, once in the morning, noon and evening every day. One course of treatment is 7 days, and take 3 courses in a row.

[0062] 4. Efficacy evaluation criteria

[0063] Significant effect: migraine symptoms disappear, physical condition returns to normal, and the patient is cured;

[0064] Improvement: Migraine symptoms improved significantly, nausea and vomiting were alleviated, and gradually returned to normal;

[0065] Invalid: Failure to meet the improvement criteria.

[0066] 5. Treatment results

[0067]

[0068] In the above treatment, 20 patients with migraine were treated with the drug of the present invention, and 15 of them were significantly effective, with a significant efficiency rate of 75%, 4 of them were improved, with an improvement rate of 20%, and 1 of them was ineffective, with a total effective rate of 95%.

[0069] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0070] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A medicinal external wash powder for treating migraine, characterized in that: The invention is prepared from the following raw materials in parts by weight: 15-20 grams of gastrodia elata, 10-15 grams of chuanxiong, 6-8 grams of angelica dahurica, 7-9 grams of notopterygium wilfordii, 11-14 grams of siler and 3-5 grams of asarum.

2. The medicinal external wash powder for treating migraine according to claim 1, characterized in that: Specifically, the invention is prepared from the following raw materials in parts by weight: 17 grams of Gastrodia elata, 12 grams of Chuanxiong rhizome, 7 grams of Angelica dahurica, 8 grams of Notopterygium wilfordii, 13 grams of Saposhnikovia divaricata, and 4 grams of Asarum.

3. A method for preparing a medicinal external wash powder for treating migraine according to claim 1-2, characterized in that: The following steps are involved: S1: Select and weigh in order according to weight, such as Gastrodia elata, Chuanxiong, Angelica dahurica, Notopterygium wilfordii, Saposhnikovia divaricata, Asarum sieboldii, wash, cut and dry; S2: Put the dried medicinal materials into a grinder and grind them into fine powder; S3: Use a sieve to sift the powder to remove coarse particles; S4: Mix different medicinal powders evenly according to proportion; S5: Put the mixed powder into a dry, sealed container and store it in a cool and dry place; S6: Take the powder as needed, mix it with warm water, and wash the affected area or apply it with a wet cloth.

4. The method for preparing the medicinal external wash powder for treating migraine according to claim 3, characterized in that: The S1 further comprises: Select and weigh Chinese medicinal materials, such as Gastrodia elata, Chuanxiong, Angelica dahurica, Notopterygium wilfordii, Saposhnikovia divaricata, and Asarum. First, accurately weigh these medicinal materials according to the weight required by the recipe, then wash them with clean water to remove surface dust and impurities, then cut the medicinal materials into small pieces or cubes. The cut medicinal materials need to be dried in a well-ventilated and cool place.

5. The method for preparing the medicinal external wash powder for treating migraine according to claim 1, characterized in that: The S3 further comprises: Pour the crushed powder into a fine sieve, select the size of the sieve holes, and then gently tap the edge of the sieve to allow the fine powder to gradually pass through the sieve holes and fall into a clean container. After screening, collect the coarse particles remaining on the sieve, crush them again, and sieve them again until all the powder reaches the required uniform fineness.

6. The method for preparing the medicinal external wash powder for treating migraine according to claim 1, characterized in that: The S4 further comprises: Weigh the sieved medicinal powders according to the formula ratio, and then pour the powders into a large, static-free mixing container in turn. Use a dry, clean stirring tool. When mixing, pay attention to the intensity and uniformity of the stirring. Continue stirring and take out some of the mixed powders for visual inspection. Ensure that the environment is dry during the mixing process.

7. The method for preparing the medicinal external wash powder for treating migraine according to claim 1, characterized in that: The S6 further comprises: Take out the powder, usually 20-30 grams, pour it into a clean bowl, then pour in 500 ml of warm water, stir thoroughly with a clean spoon until the powder is completely dissolved to form a liquid medicine. If it is for external washing of the affected area, pour the liquid medicine into a washbasin or a large bowl. The patient can dip a towel in the liquid medicine and gently wipe the affected area, or directly soak the affected area in the liquid medicine for 15-20 minutes. If used for wet cloth application to the affected area, dip a clean cotton cloth or gauze in the liquid medicine, take it out after full absorption, gently wring it until no water drips, and then apply it to the affected area for 20-30 minutes. It can be covered with plastic wrap during this period. After use, it can be repeated as needed. It is recommended to apply 1-2 times a day until the symptoms are relieved.

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