Application of protein deacetylase inhibitor NAM in ultralow-temperature cryopreservation of poultry semen

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By using the protein deacetylation inhibitor NAM to inhibit the deacetylation modification of sperm cells, the problem of poor anti-freeze ability of chicken sperm in ultra-low temperature cryopreservation is solved, and the fertilization ability and cryopreservation efficiency of frozen-rethawed sperm are significantly improved.

CN119699307AActive Publication Date: 2025-03-28INSTITUTE OF ANIMAL SCIENCES OF CHINESE ACADEMY OF AGRICULTURAL SCIENCES

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Patent Information

Application Number: CN202411784031.0
Authority / Receiving Office: CN · China
Patent Type: Applications(China)
Current Assignee / Owner
Filing Date: 2024-12-05
Publication Date: 2025-03-28
Estimated Expiration: 2044-12-05

Application Information

Patent Timeline

05 Dec 2024

Application

CN202411784031.0

28 Mar 2025

Publication

CN119699307A

IPC: A01N1/125

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Application Domain

Dead animal preservation

Technology Topics

Physiology Biochemistry

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AI Technical Summary

Technical Problem

Chicken sperm has poor anti-freeze ability in ultra-low temperature cryopreservation, resulting in a decrease in freezing damage and fertilization ability, and lacks effective protection and damage repair mechanisms.

Method used

NAM uses the protein deacetylation modification of sperm cells, maintain a high level of acetylation modification, and improve the tolerance and fertilization ability of sperm to ultra-low-temperature cryogenic stimulation.

Benefits of technology

By inhibiting the activity of deacetylase, reducing sperm freezing damage and improving the fertilization ability of frozen-rethawed sperm, it significantly improves the efficiency of ultra-low-temperature cryopreservation of poultry semen.

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Abstract

The invention provides application of a protein deacetylase inhibitor NAM in ultralow-temperature cryopreservation of poultry semen, and belongs to the technical field of poultry breed conservation. The protein deacetylase inhibitor NAM is used as a cryoprotectant or is combined with other cryoprotectants for use, and the protein deacetylase inhibitor NAM is used as an effective component, so that the ultralow-temperature cryopreservation efficiency of poultry can be improved. Wherein the protein deacetylase inhibitor NAM can inhibit sperm cell deacetylation modification so as to maintain a high acetylation modification level, improve the ability of sperms to respond to ultralow temperature freezing stimulation and improve the fertilization ability of frozen-remelted sperms.

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