Micro-needle application packaged by liquid metal

Abstract

The invention discloses a microneedle application packaged by liquid metal, and relates to the technical field of microneedle application, the microneedle application comprises gauze, the microneedle application further comprises a first application and a second application, the first application and the second application are the same in structure and are arranged on the two sides of the gauze, and the first application comprises a pressing part and an attaching part; the microneedles are arranged below the attaching piece in a linear array mode, the interiors of the microneedles are of hollow structures, and the inclination direction of the microneedles located in the first application body is opposite to the inclination direction of the second application body. The microneedles of the two microneedle application bodies are arranged to be inclined, the inclination directions of the microneedles of the two microneedle application bodies are opposite, so that a structure similar to a clamping jaw is formed, the attaching strength of the application body and the skin of a patient is improved, meanwhile, liquid metal is added into the microneedle application bodies and powered on, an electric field is formed at the wound of the patient, and the wound of the patient is wound. Therefore, continuous electrical stimulation is performed on the wound, and wound healing is actively promoted.

Description

Technical Field

[0001] The invention relates to the technical field of microneedle application technology, and in particular to a liquid metal packaged microneedle application. Background Art

[0002] In the medical field, wound healing is the focus of medical attention. Among them, linear wounds, as a common type of wound, often occur in daily life and clinical situations such as surgery. There are many methods to treat linear wounds, including sutures, cohesive bandages, hydrogel dressings, microneedles, etc. As an emerging medical device, microneedles provide new ideas for linear wound healing because they can penetrate the skin without leaving scars and can deliver drugs almost painlessly. However, microneedles in the prior art generally have a straight, symmetrical shape and cannot fit firmly to the skin. Due to poor adhesion, these microneedles have difficulty overcoming skin tension or fixing the skin around the wound, resulting in secondary wound rupture.

[0003] A Chinese patent with application number 202010303057.4 discloses a conductive microneedle patch for wound repair and a preparation method thereof. The method uses multi-template replication and step-by-step curing to prepare a conductive microneedle unit with an inclined needle tip and wrapped in an "E-shaped" guide rail; two conductive microneedle units with opposite needle tips are connected to the gauze at intervals, and are connected to the positive and negative poles of the power supply respectively through wires fixed in the "E-shaped" guide rail, thereby preparing a claw-shaped conductive microneedle patch. The conductive microneedle patch prepared by this invention can be attached to the wound surface, and its claw-shaped needle tip is conducive to the contraction and fixation of the wound surface. When connected to an external power supply, a spatial electric field is formed between the two microneedle units, which can induce cell migration and promote cell proliferation and differentiation, thereby accelerating wound healing. It has diverse functions, significant therapeutic effects, and a wide range of applications.

[0004] Similar to the above-mentioned microneedle dressing in the prior art, the connection strength between the dressing and the skin is improved by tilting the needle tip to form a claw-like structure. However, since the needle tip is set in a tilted state, when the dressing needs to be fixed on both sides of a linear wound, it is difficult to maintain a uniform angle between the tilt angle of the needle tip and the direction of force applied. Therefore, this type of dressing is difficult to connect to and remove from the skin.

[0005] Moreover, after such a patch is pierced through the patient's skin and fixed, if the patient's muscles in the wound area move due to daily activities or other behaviors, it will still push the microneedle to move slightly, which can easily cause the microneedle tip to shift, resulting in a decrease in the effect of drugs and electrotherapy on repairing the wound.

[0006] Therefore, it is necessary to invent a liquid metal encapsulated microneedle patch to solve the above problems. Summary of the invention

[0007] The object of the present invention is to provide a liquid metal encapsulated microneedle patch to solve the problems raised in the above background technology.

[0008] To achieve the above object, the present invention provides the following technical solution: a liquid metal encapsulated microneedle patch, comprising gauze, and the microneedle patch further comprises: A first dressing and a second dressing, wherein the first dressing and the second dressing have the same structure and are arranged on both sides of the gauze, and the first dressing comprises a pressing portion and a fitting member; Microneedles, a plurality of the microneedles are arranged in a linear array below the patch, the microneedles are hollow, and the inclination direction of the microneedles in the first patch is opposite to that of the second patch; A flow guide portion, the flow guide portion is arranged in the fitting and is filled with liquid metal; A limiting member is provided on the microneedle, and the limiting member can fix the microneedle through the flow of liquid metal after the microneedle penetrates the skin.

[0009] Preferably, the pressing portion comprises a fixing member, the fixing member is fixedly connected to the fitting member, a plurality of pressing holes are provided in a ring array on the fixing member, and two adsorption members are symmetrically provided on both sides of one end of the fixing member away from the fitting member.

[0010] Preferably, a pressing piece is arranged above the end of the fixing piece away from the fitting piece, and a plurality of connecting rods are arranged on the pressing piece in a linear array, and the ends of the connecting rods away from the pressing piece pass through the pressing holes and are commonly connected to a pushing piece.

[0011] Preferably, the guide portion includes a guide groove, which is opened at one end of the fitting close to the fixing member, and a plurality of guide holes are opened on the guide groove in a linear array, and a conductive hole is opened on one side of the fitting, and the conductive hole extends into the guide groove, and a wire is arranged in the conductive hole.

[0012] Preferably, a cavity is provided inside the fitting, and a plurality of slide grooves are provided on the side walls of the fitting cavity. The guide portion also includes a sliding member, which is arranged inside the fitting and slidably connected to the fitting through the slide grooves. A limiting hole is provided in each of the slide grooves, and the limiting hole passes through the side walls of the fitting and is connected to the outside world. A protrusion is provided at one end of the sliding member close to the slide groove, and the protrusion extends into the slide groove.

[0013] Preferably, a telescopic hose is provided at one end of the sliding member close to the guide groove, and the end of the sliding member away from the guide groove is connected to the microneedle, and a connecting groove is provided on the sliding member to enable the telescopic hose and the inside of the microneedle to be connected, so that the liquid metal filled in the guide groove can flow into the microneedle through the telescopic hose.

[0014] Preferably, a movable groove is provided on the side wall of each microneedle close to the sliding member, a flexible membrane capable of expansion and contraction is provided in the movable groove, and the flexible membrane is communicated with the inner cavity of the microneedle.

[0015] Preferably, the outer side of the flexible membrane is provided with a stopper fixedly connected thereto, one end of the stopper away from the flexible membrane is movably connected to the movable groove, and the stopper can extend out of the movable groove according to the expansion of the flexible membrane.

[0016] Preferably, an oblique hole having the same inclination angle as that of the microneedle is formed in the contact area between the fitting and the microneedle, and the microneedle can be obliquely extended outward from the cavity of the fitting by the flow of liquid metal under the pressure of the pressing part.

[0017] Preferably, the fitting, microneedles and fixing element are all made of pre-gel.

[0018] Technical effects and advantages of the present invention: 1. The present invention arranges the microneedles of two microneedle patches to be inclined and the inclination directions of the microneedles of the two microneedle patches are opposite, thereby forming a claw-like structure, thereby improving the adhesion strength between the patch and the patient's skin. At the same time, by adding liquid metal to the microneedle patch and energizing it, an electric field is formed at the patient's wound, thereby continuously electrically stimulating the wound and actively promoting wound healing.

[0019] 2. The present invention uses the mutual cooperation of devices such as a pressing part and a fitting part to push the microneedle to slide obliquely out of the fitting part through the sliding part and penetrate into the patient's skin, thereby effectively solving the problem that when the needle tip is set in an inclined state, it is difficult to connect with and remove the patch from the skin because the inclination angle of the needle tip and the doctor's force direction are difficult to maintain a uniform angle when the patch needs to be fixed on both sides of a linear wound.

[0020] 3. The present invention uses the mutual cooperation of devices such as the pressing piece and the fitting piece, and the setting of the flexible film. When the pressure in the microneedle gradually increases, the liquid metal in the microneedle can push the flexible film to expand, so that the limiter connected to the flexible film rotates in the direction away from the microneedle, thereby forming a barb-like structure on the microneedle and further fixing it on the skin, thereby avoiding the problem of small shaking of the microneedle during the treatment process, which leads to a deterioration in the effect of repairing the wound with drugs and electrotherapy. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 It is a schematic diagram of the overall structure of the present invention.

[0022] Figure 2 It is a schematic diagram of the overall structure of the present invention from another angle.

[0023] Figure 3It is a schematic diagram of the disassembled structure of the pressing portion and the bonding piece of the present invention.

[0024] Figure 4 It is a schematic cross-sectional view of the internal structure of the bonding piece of the present invention.

[0025] Figure 5 For the present invention Figure 4 Schematic diagram of the mechanism structure at A in the middle.

[0026] Figure 6 Schematic diagram of the microneedle and limiter structure of the present invention.

[0027] In the figure: 1. first patch; 11. pressing part; 111. fixing part; 112. pressing hole; 113. adsorption part; 114. pressing part; 115. connecting rod; 116. pushing part; 12. fitting part; 13. microneedle; 14. guide part; 141. guide groove; 142. guide hole; 143. sliding part; 144. telescopic hose; 15. limiting part; 2. second patch; 3. gauze; 4. conductive hole; 5. slide groove; 6. limiting hole; 7. movable groove; 8. flexible film. DETAILED DESCRIPTION

[0028] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0029] To avoid the problem that the dressing cannot fit firmly with the skin, and due to poor adhesion, the microneedle is difficult to overcome the skin tension or fix the skin around the wound, resulting in secondary wound dehiscence, such as Figures 1 to 6 As shown, the first embodiment of the present invention provides a liquid metal encapsulated microneedle patch, including gauze 3, and the microneedle patch also includes: a first patch 1 and a second patch 2, the first patch 1 and the second patch 2 have the same structure and are arranged on both sides of the gauze 3, and the first patch 1 includes a fitting 12.

[0030] In this embodiment, the first patch 1 also includes microneedles 13, and a plurality of microneedles 13 are arranged in a linear array below the patch 12. The microneedles 13 have a hollow structure, and the inclination direction of the microneedles 13 in the first patch 1 is opposite to that of the second patch 2. By setting the inclination angles of the microneedles 13 on the first patch 1 and the second patch 2 to be opposite, the first patch 1 and the second patch 2 form a claw-like structure after being bonded to the patient's skin, thereby improving the fit between the patch and the patient's skin.

[0031] In this embodiment, the first patch 1 also includes a guide portion 14, which is arranged in the fitting 12 and is filled with liquid metal. The guide portion 14 includes a guide groove 141, which is opened on the fitting 12 and is connected to the inner cavity of the microneedle 13. A conductive hole 4 is opened on one side of the fitting 12, and the conductive hole 4 extends into the guide groove 141. A wire is arranged in the conductive hole 4. Through an external power supply, the liquid metal generates a spatially distributed electric field at the wound surface, which continuously electrically stimulates the wound and promotes wound repair.

[0032] In this embodiment, the fitting 12 and the microneedle 13 are both made of pre-gel; specifically, 80% PEGDA (polyethylene glycol diacrylate) and 1% HMPP (High Modulus Polypropylene, a high modulus polypropylene) are dissolved together in deionized water to prepare a pre-gel, which is then injected into a mold and placed in a vacuum environment. After ten minutes, the pre-gel is taken out and then removed from the mold after being irradiated with ultraviolet light and cured.

[0033] However, since the needle tip is set in an inclined state, when the patch needs to be fixed on both sides of a linear wound, it is difficult to maintain a uniform angle between the inclination angle of the needle tip and the direction of force applied by the doctor. Therefore, this type of patch is difficult to connect to and remove from the skin; and, after such a patch is pierced through the patient's skin for fixation, if the patient's muscles in the wound area move due to daily activities or other behaviors, it will still push the microneedle 13 to move slightly, which can easily cause the needle tip of the microneedle 13 to deviate, resulting in a decrease in the effect of drugs and electrotherapy on repairing the wound.

[0034] To solve the above problems, in another embodiment of the present invention, the first patch 1 also includes a pressing portion 11, the pressing portion 11 includes a fixing member 111, the fixing member 111 is fixedly connected to the fitting member 12, a plurality of pressing holes 112 are provided on the fixing member 111 in a ring array, two adsorption members 113 are symmetrically arranged on both sides of one end of the fixing member 111 away from the fitting member 12, a pressing member 114 is arranged above one end of the fixing member 111 away from the fitting member 12, a plurality of connecting rods 115 are provided on the pressing member 114 in a linear array, one end of the connecting rod 115 away from the pressing member 114 passes through the pressing hole 112 and is commonly connected to a pushing member 116, a plurality of guide holes 142 are provided on the guide groove 141 in a linear array, the shape of the pushing member 116 is exactly the same as that of the guide groove 141, and the pushing member 116 can push the liquid metal in the guide groove 141 to flow into the guide hole 142.

[0035] In this embodiment, a cavity is opened inside the fitting 12, and a plurality of slide grooves 5 are opened on the side wall of the cavity of the fitting 12. The guide portion 14 also includes a sliding member 143, and the sliding member 143 is arranged in the fitting 12 and is slidably connected to the fitting 12 through the slide groove 5. A limiting hole 6 is opened in each slide groove 5, and the limiting hole 6 passes through the side wall of the fitting 12 and is connected to the outside. A protrusion is provided at one end of the sliding member 143 close to the slide groove 5, and the protrusion extends into the slide groove 5.

[0036] It should be noted that the protrusion is made of a flexible material. When the sliding member 143 slides in the fitting member 12, the sliding member 143 can drive the protrusion to slide in the slide groove 5. When the protrusion coincides with the limiting hole 6 during the sliding process, the protrusion can extend into the limiting hole 6 to limit the fitting member 12. At the same time, it can be judged whether the sliding member 143 has moved to the preset position by observing whether the protrusions on both sides extend into the limiting hole 6 at the same time.

[0037] In this embodiment, a telescopic hose 144 is provided at one end of the sliding member 143 close to the guide groove 141, and the end of the sliding member 143 away from the guide groove 141 is connected to the microneedle 13, and a connecting groove is provided on the sliding member 143 to enable the telescopic hose 144 to connect with the inside of the microneedle 13, so that the liquid metal filled in the guide groove 141 can flow into the microneedle 13 through the telescopic hose 144.

[0038] In this embodiment, the first patch 1 further includes a stopper 15 , which is disposed on the microneedle 13 . The stopper 15 can fix the microneedle 13 through the flow of liquid metal after the microneedle 13 penetrates the skin.

[0039] In this embodiment, a movable groove 7 is formed on the side wall of each microneedle 13 near the sliding member 143 . A flexible membrane 8 capable of expansion and contraction is disposed in the movable groove 7 . The flexible membrane 8 is connected to the inner cavity of the microneedle 13 .

[0040] In this embodiment, the outer side of the flexible membrane 8 is fixedly connected to a limiter 15 , and one end of the limiter 15 away from the flexible membrane 8 is movably connected to the movable groove 7 , and the limiter 15 can extend out of the movable groove 7 according to the expansion of the flexible membrane 8 .

[0041] It should be noted that the movable groove 7 on each microneedle 13 is provided on the side opposite to the tilting direction thereof, so as to facilitate the extension of the stopper 15 .

[0042] In this embodiment, an inclined hole having the same inclination angle as that of the microneedle 13 is provided in the contact area between the fitting 12 and the microneedle 13 , and the microneedle 13 can extend obliquely outward from the cavity of the fitting 12 by the flow of liquid metal under the pressure of the pressing portion 11 .

[0043] When in use, first fix the first dressing 1 and the second dressing 2 on both sides of the linear wound. At this time, since the microneedles 13 are contracted in the inner cavity of the fitting 12, the first dressing 1 and the second dressing 2 will not be subject to additional resistance, so that the first dressing 1 and the second dressing 2 can be closely fitted to the patient's skin. Then, the pressing member 114 is pushed to move in the direction of the fitting 12. In this process, since the pushing member 116 is connected to the pressing member 114 through a plurality of connecting rods 115, the pushing member 116 can be synchronously moved in the direction close to the guide groove 141 during the movement of the pressing member 114, and the liquid metal in the guide groove 141 is squeezed, so that the liquid metal in the guide groove 141 flows into the telescopic hose 144 through the guide hole 142. At this time, since the sliding member 143 is located above the fitting 12, the telescopic hose 144 can be stretched. The telescopic hose 144 is in a contracted state. When the liquid metal continuously flows into the telescopic hose 144 through the guide hole 142, the pressure in the telescopic hose 144 increases, thereby extending the telescopic hose 144 and pushing the sliding member 143 to move away from the fixing member 111. Since the bottom of the fitting 12 is set as an inclined hole and the slide groove 5 is inclined, the sliding of the sliding member 143 is an oblique sliding, and the inclination angle is the same as the inclination angle of the microneedle 13, so that the microneedle 13 is pushed by the sliding member 143 to slide obliquely out of the fitting 12 and penetrate into the patient's skin, thereby effectively solving the problem that the needle tip is set in an inclined state. When the dressing needs to be fixed on both sides of the linear wound, it is difficult to maintain a uniform angle between the inclination angle of the needle tip and the doctor's force direction, so that this type of dressing is difficult to connect to and remove from the skin.

[0044] After the microneedle 13 penetrates the patient's skin and is fixed, the pressing piece 114 continues to be pushed to move in the direction of the fitting piece 12, and the liquid metal in the guide groove 141 is squeezed to make the liquid metal continue to flow into the microneedle 13. At this time, since the extension of the telescopic hose 144 has reached the maximum value, the telescopic hose 144 cannot continue to extend. Moreover, through the setting of the flexible membrane 8, when the pressure in the microneedle 13 gradually increases, the liquid metal in the microneedle 13 can push the flexible membrane 8 to expand, so that the limiting piece 15 connected to the flexible membrane 8 rotates in the direction away from the microneedle 13, thereby forming a barb-like structure on the microneedle 13 and further fixing it on the skin, thereby avoiding the microneedle 13 from shaking slightly during the treatment process, resulting in the problem of poor effect of repairing the wound with drugs and electrotherapy.

[0045] It should be noted that the limiter 15 is disposed in the upper half of the microneedle 13, ie, the area where the microneedle 13 contacts the patient's epidermis, so as to prevent the limiter 15 from affecting the therapeutic effect of the microneedle 13 on the patient's wound.

[0046] When the sliding member 143 contacts the bottom of the cavity of the fitting member 12 during the movement, it means that the microneedle 13 has completely penetrated the patient's skin to reach the preset position. In this state, the protrusion set on the sliding member 143 can completely overlap with the limiting hole 6, and the pressing member 114 is completely fitted with the adsorbent 113. The pressing member 114 is connected to the adsorbent 113 by applying a sticky substance on the surface of the adsorbent 113, thereby preventing the pressing member 114 from rebounding and causing the microneedle 13 to deviate in position. The protrusion on the sliding member 143 is engaged with the limiting hole 6, which performs secondary positioning of the sliding member 143. When the patient moves the muscles at the wound during daily activities, causing the microneedle 13 to be accidentally ejected, the protrusion on the sliding member 143 will not be engaged with the limiting hole 6. Therefore, by observing the connection state between the protrusion and the limiting hole 6, it is possible to intuitively determine whether the microneedle 13 is offset, and by pressing the pressing member 114, the offset microneedle 13 can be corrected, further improving the healing effect of the device on the patient's wound.

[0047] Finally, it should be noted that the above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, it is still possible for those skilled in the art to modify the technical solutions described in the aforementioned embodiments or to make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A liquid metal encapsulated microneedle patch, comprising gauze (3), characterized in that: The microneedle application also includes: A first dressing (1) and a second dressing (2), wherein the first dressing (1) and the second dressing (2) have the same structure and are arranged on both sides of the gauze (3), and the first dressing (1) comprises a pressing portion (11) and a fitting member (12); Microneedles (13), wherein a plurality of the microneedles (13) are arranged in a linear array below the patch (12), the microneedles (13) are hollow structures, and the inclination direction of the microneedles (13) in the first patch (1) is opposite to the inclination direction of the second patch (2); A flow guide portion (14), the flow guide portion (14) being arranged in the fitting (12), and the flow guide portion (14) being filled with liquid metal; A limiting member (15), wherein the limiting member (15) is arranged on the microneedle (13), and the limiting member (15) can fix the microneedle (13) through the flow of liquid metal after the microneedle (13) pierces the skin.

2. The microneedle patch according to claim 1, characterized in that: The pressing portion (11) comprises a fixing member (111), the fixing member (111) being fixedly connected to the fitting member (12), the fixing member (111) being provided with a plurality of pressing holes (112) in a circular array, and two adsorption members (113) being symmetrically arranged on both sides of an end of the fixing member (111) away from the fitting member (12).

3. The microneedle patch according to claim 2, characterized in that: A pressing piece (114) is arranged above one end of the fixing piece (111) away from the fitting piece (12); a plurality of connecting rods (115) are arranged on the pressing piece (114) in a linear array; one end of the connecting rod (115) away from the pressing piece (114) passes through the pressing hole (112) and is connected to a pushing piece (116).

4. The microneedle patch according to claim 3, characterized in that: The guide portion (14) comprises a guide groove (141), the guide groove (141) being provided at one end of the fitting (12) close to the fixing member (111), the guide groove (141) being provided with a plurality of guide holes (142) in a linear array, a conductive hole (4) being provided on one side of the fitting (12), the conductive hole (4) extending into the guide groove (141), and a conductive wire being provided in the conductive hole (4).

5. The microneedle patch according to claim 4, characterized in that: The fitting (12) has a cavity formed inside, and a plurality of slide grooves (5) are formed on the side wall of the cavity of the fitting (12). The guide portion (14) further comprises a sliding member (143), and the sliding member (143) is arranged inside the fitting (12) and is slidably connected to the fitting (12) through the slide grooves. A limiting hole (6) is formed in each of the slide grooves (5), and the limiting hole (6) passes through the side wall of the fitting (12) and is in communication with the outside. A protrusion is formed at one end of the sliding member (143) close to the slide groove (5), and the protrusion extends into the slide groove (5).

6. The microneedle patch according to claim 5, characterized in that: A telescopic hose (144) is provided at one end of the sliding member (143) close to the guide groove (141), and an end of the sliding member (143) away from the guide groove (141) is connected to the microneedle (13). A connecting groove is provided on the sliding member (143) so that the telescopic hose (144) and the inside of the microneedle (13) can be connected. Liquid metal filled in the guide groove (141) can flow into the microneedle (13) through the telescopic hose (144).

7. The microneedle patch according to claim 6, characterized in that: A movable groove (7) is provided on a side wall of each microneedle (13) close to the sliding member (143), a flexible membrane (8) capable of expansion and contraction is provided in the movable groove (7), and the flexible membrane (8) is communicated with the inner cavity of the microneedle (13).

8. The microneedle patch according to claim 7, characterized in that: The outer side of the flexible membrane (8) is provided with a stopper (15) fixedly connected thereto; one end of the stopper (15) away from the flexible membrane (8) is movably connected to the movable groove (7); the stopper (15) can extend out of the movable groove (7) according to the expansion of the flexible membrane (8).

9. The microneedle patch according to claim 8, characterized in that: An inclined hole having the same inclination angle as that of the microneedle (13) is provided in the contact area between the fitting (12) and the microneedle (13); the microneedle (13) can extend obliquely outward from the cavity of the fitting (12) through the flow of liquid metal under the pressure of the pressing portion (11).

10. The microneedle patch according to claim 9, characterized in that: The fitting piece (12), the microneedle (13) and the fixing piece (111) are all made of pre-gel.

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