Degradable stent suitable for end-to-end anastomosis of bile duct in liver transplantation

Abstract

The invention discloses a degradable stent suitable for bile duct end-to-end anastomosis in liver transplantation, which comprises a transverse stent assembly, a longitudinal stent assembly, a regularly degradable connecting assembly, a transverse tube body, a baffle net, a connecting sleeve, an end sleeve, a clearance hole, a longitudinal tube body, a regularly degradable sleeve and a regularly degradable filling block, firstly, butt joint of donor biliary tracts and recipient biliary tracts with different pipe diameters can be achieved through the transverse support, the matching degree and applicability are improved, in-vitro communication and drainage and perfusion are facilitated through the longitudinal support at the initial stage of catheter indwelling, secondly, the regularly degradable sleeve and the regularly degradable filling block can be continuously degraded by secretion in the body of a patient and decomposed after a certain period of time, and the catheter indwelling effect is improved. Butt joint of the transverse stent assembly and the longitudinal stent assembly is canceled, the transverse stent assembly and the longitudinal stent assembly are separated, the longitudinal stent assembly can be detached and taken out conveniently, finally, by means of the gridding structure of the blocking net, accumulation of the biological adhesive can be facilitated, the blocking net is blocked, and after the longitudinal stent assembly and the transverse stent assembly are separated, a transverse pipe body in the transverse stent assembly is in a sealed state.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a degradable stent suitable for end-to-end anastomosis of bile ducts in liver transplantation. Background Art

[0002] At present, liver transplantation requires end-to-end anastomosis of the donor bile duct and the recipient bile duct, and biliary complications after liver transplantation are still one of the common complications after liver transplantation (the incidence rate is 10%-30%), among which the most common are bile duct stenosis and bile leakage (accounting for about 70%). It seriously threatens the quality of life of patients after liver transplantation, especially because the donor bile duct and the recipient bile duct come from different individuals, the bile duct diameters are different, and the diameters do not match, which makes it easier to have biliary complications after surgery. The traditional T-shaped bile duct stent is generally simple in structure. Not only are the diameters of both ends of the pipe consistent, but they do not have size specifications and poor applicability. In addition, the transverse tube body and the longitudinal tube body are integrated structures, which cannot be easily separated and degraded after a certain period of time, and then a secondary operation is required to remove the tube, which is time-consuming and laborious, increases unnecessary costs and medical resources, and also brings great safety risks. Therefore, in view of the above defects, it is necessary to design a degradable stent suitable for end-to-end anastomosis of the bile duct in liver transplantation. Summary of the invention

[0003] The technical problem to be solved by the present invention is to provide a degradable stent suitable for end-to-end anastomosis of bile duct in liver transplantation, so as to solve the problems raised by the background technology.

[0004] In order to solve the above technical problems, the technical solution of the present invention is: a degradable stent suitable for end-to-end anastomosis of bile duct in liver transplantation, comprising a transverse stent assembly, a longitudinal stent assembly and a periodic degradation connection assembly, wherein the transverse stent assembly is composed of a transverse tube body, a retaining net and a connecting sleeve, the longitudinal stent assembly is composed of an end sleeve, an air avoidance hole and a longitudinal tube body, the periodic degradation connection assembly is composed of a periodic degradation sleeve and a periodic degradation filling block, the longitudinal stent assembly is located at the middle end of the bottom of the transverse stent assembly, the longitudinal stent assembly and the transverse stent assembly are movably connected, the periodic degradation connection assembly is sleeved on the outer wall of the connection between the transverse stent assembly and the longitudinal stent assembly, the periodic degradation connection assembly is respectively connected to the transverse stent assembly and the longitudinal stent assembly by adhesive bonding, the retaining net is fixed on the lower side of the middle end of the transverse tube body, and the retaining net and the transverse tube body are connected by Hot-melt connection, the connecting sleeve is fixedly arranged at the bottom of the retaining net, the connecting sleeve is integrally formed with the retaining net, and the connecting sleeve is connected with the transverse tube body by hot-melt connection, the end sleeve is arranged on the outer wall of the connecting sleeve, the end sleeve and the connecting sleeve are plug-in docking, the number of the air-avoiding holes is several, the air-avoiding holes are distributed in a circle outside the end sleeve, the air-avoiding holes are through holes, the longitudinal tube body is fixedly arranged at the bottom of the end sleeve, the longitudinal tube body is integrally formed with the end sleeve, the periodically degradable sleeve is fixedly arranged on the connecting sleeve and the outer wall of the end sleeve, the periodically degradable sleeve is connected to the connecting sleeve and the end sleeve by adhesive bonding, the number of the periodically degradable filling blocks is several, the periodically degradable filling blocks are uniformly surrounded by the inner wall of the periodically degradable sleeve, the periodically degradable filling blocks are integrally formed with the periodically degradable sleeve, and the periodically degradable filling blocks are respectively connected to the connecting sleeve and the end sleeve by adhesive bonding;

[0005] The transverse stent assembly can dock with the separated bile duct in the patient's body to realize an artificial duct, and the longitudinal stent assembly can facilitate communication with the outside of the body at the initial stage of catheterization, facilitating drainage and infusion of liquid medicine;

[0006] The periodically degradable sleeve and the periodically degradable filling block in the periodically degradable connecting assembly can be continuously degraded by the patient's body secretions and decomposed after a certain period of time, thereby canceling the docking of the transverse support assembly and the longitudinal support assembly, allowing them to be separated, thereby facilitating the disassembly and removal of the longitudinal support assembly.

[0007] Furthermore, the transverse tube body is composed of elastic fibers, silk protein, carboxylated bacterial cellulose and gelatin, which increases the mechanical properties of the blood vessels.

[0008] Furthermore, the left and right ends of the transverse tube body are also fixed with docking membranes, the docking membranes and the transverse tube body are connected with adhesive, and the docking membranes are composed of gelatin and biological adhesives, which is conducive to docking and sticking the bile duct.

[0009] Furthermore, an external connection end is fixedly provided at the bottom of the longitudinal tube body, and the external connection end is connected to the longitudinal tube body by hot-melt connection.

[0010] Furthermore, the periodically degradable sleeve and the periodically degradable filling block are composed of gelatin, chitosan and methyl methacrylate, which are not only conducive to achieving the adhesive effect, but also can be decomposed into low molecular substances by lysozyme, decomposing enzymes and lecithin in the human body after a certain period of time.

[0011] Compared with the prior art, the degradable stent suitable for end-to-end anastomosis of the bile duct in liver transplantation has the following advantages:

[0012] 1. First, the transverse stent can achieve the docking of the donor bile duct and the recipient bile duct of different diameters, improving the matching degree and applicability. The longitudinal stent component can facilitate the connection with the outside of the body in the early stage of catheterization, which is convenient for drainage and perfusion of medicine.

[0013] 2. Secondly, the periodically degradable sleeve and the periodically degradable filling block can be continuously degraded by the patient's body secretions and decomposed after a certain period of time, thereby canceling the docking of the transverse support assembly and the longitudinal support assembly, allowing them to be separated, which is conducive to disassembling and removing the longitudinal support assembly.

[0014] 3. Finally, the grid structure of the retaining net can facilitate the accumulation of bioadhesives to achieve the purpose of blocking the retaining net, so that after the longitudinal support assembly is separated from the transverse support assembly, the transverse tube body in the transverse support assembly is in a sealed state. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 This is a front view of a biodegradable stent suitable for end-to-end anastomosis of the bile duct during liver transplantation;

[0016] Figure 2 This is a cross-sectional view in the A direction of a degradable stent suitable for end-to-end anastomosis of the bile duct during liver transplantation;

[0017] Figure 3 A stereoscopic image of a biodegradable stent suitable for end-to-end anastomosis of the bile duct during liver transplantation;

[0018] Figure 4 It is a three-dimensional image of a degradable stent in a separated state suitable for end-to-end anastomosis of the bile duct in liver transplantation;

[0019] Figure 5 is a cross-sectional, enlarged axonometric view of the transverse support assembly;

[0020] Figure 6 is a perspective view of the longitudinal bracket assembly;

[0021] Figure 7 It is a stereogram of regularly degrading connected components;

[0022] Figure 8This is a partial schematic diagram of liver transplantation.

[0023] Transverse support assembly 1, longitudinal support assembly 2, periodic degradation connection assembly 3, transverse tube body 11, retaining net 12, connection sleeve 13, end sleeve 21, air avoidance hole 22, longitudinal tube body 23, periodic degradation sleeve 31, periodic degradation filling block 32, docking membrane 111, external connection end 231.

[0024] The following specific implementation manner will be further described in conjunction with the above-mentioned drawings. DETAILED DESCRIPTION

[0025] In the following text, numerous specific details are set forth in order to provide a thorough understanding of the concepts underlying the described embodiments; however, it will be apparent to those skilled in the art that the described embodiments may be practiced without some or all of these specific details, and in other cases, well-known processing steps are not specifically described.

[0026] In the description of the invention, it is necessary to understand that the terms "upper", "lower", "front", "back", "left", "right", "top", "bottom", "inside" and "outside" etc. indicating directions or positional relationships are based on the directions or positional relationships shown in the accompanying drawings and are only for the convenience of describing the invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore cannot be understood as a limitation on the invention.

[0027] like Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 , Figure 6 , Figure 7 , Figure 8 As shown, a degradable stent suitable for end-to-end anastomosis of bile duct in liver transplantation comprises a transverse stent assembly 1, a longitudinal stent assembly 2, a periodically degradable connection assembly 3, a transverse tube body 11, a retaining net 12, a connection sleeve 13, an end sleeve 21, an air avoidance hole 22, a longitudinal tube body 23, a periodically degradable sleeve 31, a periodically degradable filling block 32, a docking membrane 111, and an external connection end 231;

[0028] In one embodiment, because the diameters of the two ends of the transverse tube 11 are different, that is, one end has a small diameter and the other end has a large diameter, the docking requirements of the ports of the donor bile duct end and the recipient bile duct end are met, thereby improving the convenience and safety of surgical operation;

[0029] In one embodiment, the bioadhesive of the docking membrane 111 in the transverse stent assembly 1 can improve the docking adhesion with the patient's bile duct and increase the stability of the artificial duct placement;

[0030] In one embodiment, the connecting sleeve 13 in the transverse support assembly 1 can be plugged and docked with the end sleeve 21 in the longitudinal support assembly 2, and with the help of the periodically degradable sleeve 31 in the periodically degradable connecting assembly 3 and the chitosan and methyl methacrylate of the periodically degradable filling block 32, it is not only conducive to achieving the adhesion effect, but also can be decomposed into low molecular substances by lysozyme, decomposition enzymes and lecithin in the human body after a certain period of time, that is, the docking of the transverse support assembly 1 and the longitudinal support assembly 2 is cancelled, so that they can be separated, which is conducive to disassembling and removing the longitudinal support assembly 2;

[0031] In one embodiment, the blocking net 12 in the transverse stent assembly 1 can facilitate medical staff to inject the currently available clinical bioadhesive into the blocking net 12 by means of the longitudinal tube 23 in the longitudinal stent assembly 2 before disassembling and removing the longitudinal stent assembly 2, that is, the grid structure of the blocking net 12 can facilitate the accumulation of the bioadhesive, so as to achieve the blocking of the blocking net 12, so that after the longitudinal stent assembly 2 is separated from the transverse stent assembly 1, the transverse tube 11 in the transverse stent assembly 1 is in a sealed state;

[0032] In one embodiment, the avoidance hole 22 in the longitudinal support assembly 2 can facilitate the filling and placement of the periodically degradable filling block 32 in the periodically degradable connection assembly 3, thereby increasing the contact area between the periodically degradable connection assembly 3 and the transverse support assembly 1 and the longitudinal support assembly 2, and increasing the connection effect. When the periodically degradable filling block 32 is decomposed, it does not affect the separation of the transverse support assembly 1 and the longitudinal support assembly 2.

[0033] Specifically, before the operation, the medical staff will mix the proportions of gelatin, chitosan and methyl methacrylate in the periodic degradation connection component 3 according to the patient's specific tube removal cycle. The chitosan and methyl methacrylate contents will be increased when the tube removal cycle is long, and the chitosan and methyl methacrylate contents will be reduced when the tube removal cycle is short. Then, the transverse stent component 1 and the longitudinal stent component 2 are docked with the periodic degradation connection component 3. During the operation, the docking membranes 111 at both ends of the transverse tube body 1 of the transverse stent component 1 are docked with the donor bile duct port and the recipient bile duct port of the donor liver, while the longitudinal stent component 2 is pulled to the wound position outside the body, that is, the external connection end 231 is exposed outside the body. It is fixed with medical tape. After the operation, during the patient's recovery period, medical staff use the longitudinal stent component 2 for regular drainage, infusion of medicine, etc. to improve the patient's bile duct recovery. At the same time, during this time, the patient's body secretions come into contact with the periodic degradation connection component 3, that is, the chitosan and methyl methacrylate of the periodic degradable sleeve 31 and the periodic degradable filling block 32 are decomposed. After a certain period of time, the chitosan and methyl methacrylate are decomposed, and then the periodic degradation connection component 3 cancels the docking of the transverse stent component 1 and the longitudinal stent component 2, so that they can be separated, and finally it is beneficial for medical staff to remove the longitudinal stent component 2.

[0034] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the technical principles of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A degradable stent suitable for end-to-end anastomosis of bile duct in liver transplantation, characterized in that It includes a transverse support assembly, a longitudinal support assembly and a periodic degradation connection assembly, wherein the transverse support assembly is composed of a transverse tube body, a baffle and a connection sleeve, the longitudinal support assembly is composed of an end sleeve, an air avoidance hole and a longitudinal tube body, the periodic degradation connection assembly is composed of a periodic degradation sleeve and a periodic degradation filling block, the longitudinal support assembly is located at the middle end of the bottom of the transverse support assembly, the longitudinal support assembly and the transverse support assembly are movably connected, the periodic degradation connection assembly is sleeved on the outer wall of the connection between the transverse support assembly and the longitudinal support assembly, the periodic degradation connection assembly is respectively connected to the transverse support assembly and the longitudinal support assembly by adhesive bonding, the baffle is fixedly arranged on the lower side of the middle end of the transverse tube body, the baffle is connected to the transverse tube body by hot melt, the connection sleeve is fixedly arranged at the bottom of the baffle, the The connecting sleeve is integrally formed with the retaining net, and the connecting sleeve is connected with the transverse pipe body by hot-melt connection, the end sleeve is arranged on the outer wall of the connecting sleeve, the end sleeve and the connecting sleeve are plug-in docking, the number of the air avoidance holes is several, the air avoidance holes are distributed in a circle outside the end sleeve, the air avoidance holes are through holes, the longitudinal pipe body is fixedly arranged at the bottom of the end sleeve, the longitudinal pipe body and the end sleeve are integrally formed, the periodically degradable sleeve is fixedly arranged on the connecting sleeve and the outer wall of the end sleeve, the periodically degradable sleeve is connected to the connecting sleeve and the end sleeve by adhesive bonding, the number of the periodically degradable filling blocks is several, the periodically degradable filling blocks are uniformly surrounded by the inner wall of the periodically degradable sleeve, the periodically degradable filling blocks are integrally formed with the periodically degradable sleeve, and the periodically degradable filling blocks are respectively connected to the connecting sleeve and the end sleeve by adhesive bonding; The transverse stent assembly can dock with the separated bile duct in the patient's body to realize an artificial duct, and the longitudinal stent assembly can facilitate communication with the outside of the body at the initial stage of catheterization, facilitating drainage and infusion of liquid medicine; The periodically degradable sleeve and the periodically degradable filling block in the periodically degradable connecting assembly can be continuously degraded by the patient's body secretions and decomposed after a certain period of time, thereby canceling the docking of the transverse support assembly and the longitudinal support assembly, allowing them to be separated, thereby facilitating the disassembly and removal of the longitudinal support assembly.

2. A degradable stent suitable for end-to-end anastomosis of bile duct in liver transplantation according to claim 1, characterized in that The transverse tube body is composed of elastic fiber, silk protein, carboxylated bacterial cellulose and gelatin, which increases the mechanical properties of the blood vessel.

3. A degradable stent suitable for end-to-end anastomosis of bile duct in liver transplantation according to claim 1, characterized in that The left and right ends of the transverse tube body are also fixed with docking membranes, the docking membranes and the transverse tube body are connected with adhesive, and the docking membranes are composed of gelatin and biological adhesive, which is conducive to docking and sticking the bile duct.

4. A degradable stent suitable for end-to-end anastomosis of bile duct in liver transplantation according to claim 1, characterized in that An external connection end is fixedly arranged at the bottom of the longitudinal tube body, and the external connection end is connected to the longitudinal tube body by hot melting.

5. The degradable stent for end-to-end anastomosis of bile duct in liver transplantation according to claim 1, characterized in that The periodically degradable sleeve and the periodically degradable filling block are composed of gelatin, chitosan and methyl methacrylate, which are not only conducive to achieving the adhesion effect, but also can be decomposed into low molecular substances by lysozyme, decomposition enzyme and lecithin in the human body after a certain period of time.

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