A biodegradable stent suitable for end-to-end anastomosis of bile duct in liver transplantation

Abstract

The present invention discloses a degradable stent suitable for end-to-end anastomosis of bile ducts during liver transplantation, comprising a transverse stent assembly, a longitudinal stent assembly and a periodically degradable connecting assembly, a transverse tube body, a retaining net, a connecting sleeve, an end sleeve, an air-avoiding hole, a longitudinal tube body, a periodically degradable sleeve, and a periodically degradable filling block. Firstly, the transverse stent can achieve docking of donor bile ducts and recipient bile ducts of different diameters, thereby improving matching and applicability. The longitudinal stent can facilitate in vitro communication in the early stage of catheterization, thereby facilitating drainage and perfusion. Secondly, the periodically degradable sleeve and the periodically degradable filling block can be continuously degraded by the patient's body secretions and decompose after a certain period of time, thereby eliminating the docking between the transverse stent assembly and the longitudinal stent assembly, separating them, and facilitating the disassembly and removal of the longitudinal stent assembly. Finally, the grid structure of the retaining net can facilitate the accumulation of bioadhesives, thereby achieving the blocking of the retaining net. After the longitudinal stent assembly is separated from the transverse stent assembly, the transverse tube body in the transverse stent assembly is in a sealed state.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a degradable stent suitable for end-to-end anastomosis of bile ducts in liver transplantation. Background Art

[0002] Currently, liver transplantation requires end-to-end anastomosis of the donor bile duct and the recipient bile duct, and biliary complications after liver transplantation are still one of the common complications after liver transplantation (the incidence rate is 10%-30%), of which the most common are biliary stenosis and bile leakage (accounting for about 70%). This seriously threatens the quality of life of patients after liver transplantation, especially because the donor bile duct and the recipient bile duct come from different individuals, the bile duct diameters are different, and the diameters are mismatched, which makes biliary complications more likely to occur after surgery. Traditional T-shaped bile duct stents are generally simple in structure. Not only are the diameters of the two ends of the pipe consistent, but they do not have size specifications and poor applicability. In addition, the transverse tube body and the longitudinal tube body are an integrated structure and cannot be easily separated and degraded after a certain period of time, requiring a second operation to remove the tube. This is time-consuming and labor-intensive, increases unnecessary costs and medical resources, and also brings great safety risks. Therefore, in view of the above defects, it is necessary to design a degradable stent suitable for end-to-end anastomosis of the bile duct during liver transplantation. Summary of the Invention

[0003] The technical problem to be solved by the present invention is to provide a degradable stent suitable for end-to-end anastomosis of bile ducts in liver transplantation, so as to solve the problems raised by the background technology.

[0004] In order to solve the above technical problems, the technical solution of the present invention is: a degradable stent suitable for end-to-end anastomosis of bile ducts during liver transplantation, comprising a transverse stent assembly, a longitudinal stent assembly and a periodic degradation connection assembly, the transverse stent assembly is composed of a transverse tube body, a baffle and a connection sleeve, the longitudinal stent assembly is composed of an end sleeve, an air-avoidance hole and a longitudinal tube body, the periodic degradation connection assembly is composed of a periodic degradable sleeve and a periodic degradable filling block, the longitudinal stent assembly is located at the bottom middle end of the transverse stent assembly, the longitudinal stent assembly and the transverse stent assembly are movably connected, the periodic degradation connection assembly is sleeved on the outer wall of the connection between the transverse stent assembly and the longitudinal stent assembly, the periodic degradation connection assembly is respectively connected to the transverse stent assembly and the longitudinal stent assembly by adhesive bonding, the baffle is fixed on the lower side of the middle end of the transverse tube body, the baffle and the transverse tube body are connected by Hot melt connection, the connecting sleeve is fixedly arranged at the bottom of the retaining net, the connecting sleeve and the retaining net are integrally formed, and the connecting sleeve and the transverse tube body are connected by hot melt, the end sleeve is arranged on the outer wall of the connecting sleeve, the end sleeve and the connecting sleeve are plug-in docking, the number of the avoidance holes is several, the avoidance holes are distributed in a circle outside the end sleeve, the avoidance holes are through holes, the longitudinal tube body is fixedly arranged at the bottom of the end sleeve, the longitudinal tube body and the end sleeve are integrally formed, the periodically degradable sleeve is fixedly arranged on the connecting sleeve and the outer wall of the end sleeve, the periodically degradable sleeve is connected to the connecting sleeve and the end sleeve by adhesive bonding, the number of the periodically degradable filling blocks is several, the periodically degradable filling blocks are evenly surrounded by the inner wall of the periodically degradable sleeve, the periodically degradable filling blocks are integrally formed with the periodically degradable sleeve, and the periodically degradable filling blocks are respectively connected to the connecting sleeve and the end sleeve by adhesive bonding;

[0005] The transverse stent assembly can dock with the separated bile duct in the patient's body to create an artificial tube. The longitudinal stent assembly facilitates communication with the outside of the body during the initial stage of tube placement, facilitating drainage and perfusion of medication.

[0006] The periodically degradable sleeve and the periodically degradable filling block in the periodically degradable connecting assembly can be continuously degraded by the patient's body secretions and decompose after a certain period of time, thereby canceling the docking of the transverse support assembly and the longitudinal support assembly, allowing them to be separated, thereby facilitating the disassembly and removal of the longitudinal support assembly.

[0007] Furthermore, the transverse tube is composed of elastic fibers, silk protein, carboxylated bacterial cellulose and gelatin, which increases the mechanical properties of the blood vessels.

[0008] Furthermore, the left and right ends of the transverse tube body are fixed with docking membranes, which are connected to the transverse tube body with adhesives. The docking membranes are composed of gelatin and biological adhesives, which are conducive to docking and gluing the bile duct.

[0009] Furthermore, an external connection end is fixedly provided at the bottom of the longitudinal tube body, and the external connection end is connected to the longitudinal tube body by hot melting.

[0010] Furthermore, the periodically degradable sleeve and the periodically degradable filling block are composed of gelatin, chitosan and methyl methacrylate, which not only facilitates the adhesive effect but also can be decomposed into low molecular substances by lysozyme, decomposing enzymes and lecithin in the human body after a certain period of time.

[0011] Compared with existing technologies, this biodegradable stent suitable for end-to-end anastomosis of bile ducts during liver transplantation has the following advantages:

[0012] 1. First, the transverse stent can achieve the docking of the donor bile duct and the recipient bile duct of different diameters, improving the matching and applicability. The longitudinal stent component can facilitate communication with the outside of the body in the early stage of catheterization, facilitating drainage and perfusion of drugs.

[0013] 2. Secondly, the periodically degradable sleeve and the periodically degradable filling block can be continuously degraded by the patient's body secretions and decomposed after a certain period of time, thereby canceling the docking of the transverse support assembly and the longitudinal support assembly, allowing them to be separated, which is conducive to disassembling and removing the longitudinal support assembly.

[0014] 3. Finally, the grid structure of the retaining net can facilitate the accumulation of bioadhesives, thereby sealing the retaining net. After the longitudinal support assembly is separated from the transverse support assembly, the transverse tube in the transverse support assembly is in a sealed state. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 This is a front view of a biodegradable stent suitable for end-to-end anastomosis of the bile duct during liver transplantation;

[0016] Figure 2 This is a cross-sectional view in the A direction of a biodegradable stent suitable for end-to-end anastomosis of the bile duct during liver transplantation;

[0017] Figure 3 A three-dimensional image of a biodegradable stent suitable for end-to-end anastomosis of the bile duct during liver transplantation;

[0018] Figure 4 This is a three-dimensional image of a biodegradable stent in a detached state suitable for end-to-end anastomosis of the bile duct during liver transplantation;

[0019] Figure 5 is a cross-sectional, enlarged isometric view of the transverse support assembly;

[0020] Figure 6 is a perspective view of the longitudinal bracket assembly;

[0021] Figure 7 It is a stereogram of regularly degrading connected components;

[0022] Figure 8This is a partial schematic diagram of liver transplantation.

[0023] Transverse support assembly 1, longitudinal support assembly 2, periodic degradation connection assembly 3, transverse tube body 11, retaining net 12, connection sleeve 13, end sleeve 21, air avoidance hole 22, longitudinal tube body 23, periodic degradation sleeve 31, periodic degradation filling block 32, docking membrane 111, external connection end 231.

[0024] The following specific implementation manner will be further described in conjunction with the above-mentioned drawings. DETAILED DESCRIPTION

[0025] In the following text, numerous specific details are set forth in order to provide a thorough understanding of the concepts that form the basis of the described embodiments; however, it will be apparent to those skilled in the art that the described embodiments may be practiced without some or all of these specific details. In other instances, well-known processing steps are not specifically described.

[0026] In the description of the invention, it should be understood that the terms "upper", "lower", "front", "back", "left", "right", "top", "bottom", "inside", "outside", etc., indicating directions or positional relationships, are based on the directions or positional relationships shown in the accompanying drawings. They are only for the convenience of describing the invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific direction, be constructed and operated in a specific direction. Therefore, they cannot be understood as limiting the invention.

[0027] like Figure 1 、 Figure 2 、 Figure 3 、 Figure 4 、 Figure 5 、 Figure 6 、 Figure 7 、 Figure 8 As shown, a biodegradable stent suitable for end-to-end anastomosis of bile ducts during liver transplantation comprises a transverse stent assembly 1, a longitudinal stent assembly 2, a periodically degradable connection assembly 3, a transverse tube body 11, a retaining net 12, a connection sleeve 13, an end sleeve 21, an air-avoiding hole 22, a longitudinal tube body 23, a periodically degradable sleeve 31, a periodically degradable filling block 32, a docking membrane 111, and an external connection end 231;

[0028] In one embodiment, the two ends of the transverse tube 11 have different diameters, i.e., one end has a smaller diameter and the other end has a larger diameter, thereby meeting the docking requirements of the ports at the donor bile duct end and the recipient bile duct end, thereby improving the convenience and safety of the surgical operation;

[0029] In one embodiment, the bioadhesive of the docking membrane 111 in the transverse stent assembly 1 can improve the docking adhesion with the patient's bile duct and increase the stability of the artificial tube placement;

[0030] In one embodiment, the connecting sleeve 13 in the transverse support assembly 1 can be plugged and docked with the end sleeve 21 in the longitudinal support assembly 2, and with the help of the chitosan and methyl methacrylate of the periodically degradable sleeve 31 and the periodically degradable filling block 32 in the periodically degradable connecting assembly 3, not only is it conducive to achieving an adhesive effect, but it can also be decomposed into low-molecular substances by lysozyme, decomposing enzymes and lecithin in the human body after a certain period of time, that is, the docking of the transverse support assembly 1 and the longitudinal support assembly 2 is cancelled, so that they can be separated, which is conducive to the disassembly and removal of the longitudinal support assembly 2;

[0031] In one embodiment, the retaining net 12 in the transverse stent assembly 1 can facilitate medical personnel to inject currently available clinical bioadhesive into the retaining net 12 via the longitudinal tube 23 in the longitudinal stent assembly 2 before disassembling and removing the longitudinal stent assembly 2. That is, the grid structure of the retaining net 12 can facilitate the accumulation of the bioadhesive, thereby sealing the retaining net 12. After the longitudinal stent assembly 2 is separated from the transverse stent assembly 1, the transverse tube 11 in the transverse stent assembly 1 is in a sealed state.

[0032] In one embodiment, the avoidance holes 22 in the longitudinal support assembly 2 can facilitate the filling and placement of the periodically degradable filling blocks 32 in the periodically degradable connection assembly 3, thereby increasing the contact area between the periodically degradable connection assembly 3 and the transverse support assembly 1 and the longitudinal support assembly 2, thereby enhancing the connection effect. Moreover, when the periodically degradable filling blocks 32 are decomposed, the separation of the transverse support assembly 1 and the longitudinal support assembly 2 is not affected.

[0033] Specifically, before the operation, the medical staff will adjust the ratio of gelatin, chitosan and methyl methacrylate in the periodic degradation connection component 3 according to the patient's specific tube removal cycle. The chitosan and methyl methacrylate content will be increased when the tube removal cycle is long, and the chitosan and methyl methacrylate content will be reduced when the tube removal cycle is short. Then, the transverse stent component 1 and the longitudinal stent component 2 will be docked with the periodic degradation connection component 3. During the operation, the docking membranes 111 at both ends of the transverse tube body 1 of the transverse stent component 1 will be docked with the donor biliary port and the recipient biliary port of the liver, while the longitudinal stent component 2 will be pulled to the wound position outside the body, that is, the external end 231 will be exposed outside the body. It is fixed with medical tape. After the operation, during the patient's recovery period, medical staff use the longitudinal stent assembly 2 for regular drainage, perfusion of medicine, etc. to improve the patient's bile duct recovery. At the same time, during this time, the patient's body secretions come into contact with the periodic degradation connection assembly 3, which decomposes the chitosan and methyl methacrylate of the periodic degradable sleeve 31 and the periodic degradable filling block 32. After a certain period of time, the chitosan and methyl methacrylate are decomposed, and the periodic degradation connection assembly 3 cancels the docking of the transverse stent assembly 1 and the longitudinal stent assembly 2, allowing them to separate, and ultimately facilitates medical staff to remove the longitudinal stent assembly 2.

[0034] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the technical principles of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A biodegradable stent suitable for end-to-end anastomosis of bile ducts during liver transplantation, characterized in that It includes a transverse support assembly, a longitudinal support assembly and a periodic degradation connection assembly, the transverse support assembly is composed of a transverse tube body, a baffle and a connecting sleeve, the longitudinal support assembly is composed of an end sleeve, an air-avoiding hole and a longitudinal tube body, the periodic degradation connection assembly is composed of a periodic degradable sleeve and a periodic degradable filling block, the longitudinal support assembly is located at the bottom middle end of the transverse support assembly, the longitudinal support assembly and the transverse support assembly are movably connected, the periodic degradation connection assembly is sleeved on the outer wall of the connection between the transverse support assembly and the longitudinal support assembly, the periodic degradation connection assembly is respectively connected to the transverse support assembly and the longitudinal support assembly by adhesive bonding, the baffle is fixed on the lower side of the middle end inside the transverse tube body, the baffle and the transverse tube body are connected by hot melt, the connecting sleeve is fixed on the bottom of the baffle, the The connecting sleeve is integrally formed with the baffle, and the connecting sleeve is connected to the transverse pipe body by hot melt, the end sleeve is arranged on the outer wall of the connecting sleeve, the end sleeve and the connecting sleeve are plug-in docking, the number of the avoidance holes is several, the avoidance holes are distributed in a circle outside the end sleeve, the avoidance holes are through holes, the longitudinal pipe body is fixedly provided at the bottom of the end sleeve, the longitudinal pipe body and the end sleeve are integrally formed, the periodically degradable sleeve is fixedly provided on the connecting sleeve and the outer wall of the end sleeve, the periodically degradable sleeve is connected to the connecting sleeve and the end sleeve by adhesive bonding, the number of the periodically degradable filling blocks is several, the periodically degradable filling blocks are evenly surrounded by the inner wall of the periodically degradable sleeve, the periodically degradable filling blocks are integrally formed with the periodically degradable sleeve, and the periodically degradable filling blocks are respectively connected to the connecting sleeve and the end sleeve by adhesive bonding; The transverse stent assembly can dock with the separated bile duct in the patient's body to create an artificial tube. The longitudinal stent assembly facilitates communication with the outside of the body during the initial stage of tube placement, facilitating drainage and perfusion of medication. The periodically degradable sleeve and the periodically degradable filling block in the periodically degradable connecting assembly can be continuously degraded by the patient's body secretions and decompose after a certain period of time, thereby canceling the docking of the transverse support assembly and the longitudinal support assembly, allowing them to be separated, thereby facilitating the disassembly and removal of the longitudinal support assembly.

2. A biodegradable stent suitable for end-to-end anastomosis of bile duct in liver transplantation according to claim 1, characterized in that The transverse tube body is composed of elastic fiber, silk protein, carboxylated bacterial cellulose and gelatin, which increases the mechanical properties of the blood vessel.

3. The biodegradable stent suitable for end-to-end anastomosis of bile duct in liver transplantation according to claim 1, characterized in that The left and right ends of the transverse tube body are further fixed with docking membranes, which are connected to the transverse tube body by adhesive, and the docking membranes are composed of gelatin and biological adhesive, which is conducive to docking and sticking the bile duct.

4. The biodegradable stent suitable for end-to-end anastomosis of bile duct in liver transplantation according to claim 1, characterized in that An external connection end is fixedly provided at the bottom of the longitudinal tube body, and the external connection end is connected to the longitudinal tube body by hot melting.

5. The biodegradable stent suitable for end-to-end anastomosis of bile duct in liver transplantation according to claim 1, characterized in that The periodically degradable sleeve and the periodically degradable filling block are composed of gelatin, chitosan and methyl methacrylate, which are not only conducive to achieving an adhesive effect, but can also be decomposed into low-molecular substances by lysozyme, decomposing enzymes and lecithin in the human body after a certain period of time.

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