Compound preparation for treating blade throat and preparation method thereof

Abstract

The invention discloses a compound preparation for treating blade throat and a preparation method thereof. The compound preparation is prepared from the following raw materials in parts by weight: 2-4 parts of lidocaine, 0.5-4 parts of borneol, 0.5-4 parts of menthol, 5-11 parts of fructus momordicae, 3-9 parts of fructus arctii, 6-12 parts of radix ophiopogonis, 2-8 parts of lily, 0.5-3 parts of fresh ginger, 1-5 parts of sodium carboxymethyl cellulose and 3-8 parts of cane sugar. The traditional Chinese medicine and the western medicine are matched for use, so that a rapid and completely effective analgesic effect is achieved, the analgesic duration is longer, meanwhile, the effects of detoxifying, relieving sore throat, promoting salivation, moistening lung, clearing away heart fire and tranquilizing are achieved, inflammation of the throat and the lung is eliminated, and a patient can recover rapidly without pain; the uneasiness of the patient caused by body discomfort is relieved, and the immunity of the patient is improved so as to reduce the recurrence probability.

Description

Technical Field

[0001] The present invention relates to the field of medical technology, and in particular to a compound preparation for treating "razor throat" and a preparation method thereof. Background Art

[0002] The main symptoms of novel coronavirus infection are fever, cough, sore throat, nasal congestion, body pain, fatigue, etc. Among them, the pain in the throat is the most unbearable, known as "razor throat", which seriously affects swallowing and speaking. Patients cannot drink water or eat, dare not cough, and even cannot fall asleep, which seriously affects their recovery.

[0003] For "razor throat", oral drugs such as ibuprofen, diclofenac sodium, acetaminophen, intramuscular injection drugs such as Antongding, and oral drugs such as Jinshengzi throat treasure and Xiguashuang throat tablets are currently used, but the effects are limited and cannot achieve a rapid and completely effective analgesic effect. At the same time, these drugs cannot effectively eliminate inflammation in the pharynx and lungs. After the analgesic effect ends, the patient will feel severe pain again due to the inflammatory reaction.

[0004] Lidocaine is a local anesthetic that usually takes effect within 3-5 minutes, fully takes effect within 10 minutes, and usually lasts for 60-120 minutes, usually not more than 120 minutes. The anesthesia and analgesia of lidocaine lasts for a short time, and patients will feel severe pain soon after using it, which cannot meet the analgesic needs of patients with razor throat. Summary of the invention

[0005] The object of the present invention is to provide a compound preparation for treating razor throat with rapid and completely effective analgesic effect with long duration and a preparation method thereof.

[0006] The first aspect of the present application provides a compound preparation, which is composed of the following raw materials in parts by weight: 2~4 parts of lidocaine 0.5~4 portions of borneol 0.5~4 parts of menthol 5~11 servings of monk fruit 3~9 portions of burdock seeds 6~12 servings of Ophiopogon japonicus 2~8 lilies 0.5~3 portions of ginger 1~5 parts of sodium carboxymethyl cellulose 3~8 parts of sucrose.

[0007] In an exemplary embodiment, the compound preparation is composed of the following raw materials in parts by weight: 2 parts of lidocaine, 3 parts of borneol, 4 parts of menthol, 8 parts of momordica grosvenori, 8 parts of burdock fruit, 10 parts of ophiopogon japonicus, 6 parts of lily, 2 parts of ginger, 2 parts of sodium carboxymethyl cellulose, and 7 parts of sucrose.

[0008] In an exemplary embodiment, the compound preparation is composed of the following raw materials in parts by weight: 3 parts of lidocaine, 2 parts of borneol, 3 parts of menthol, 11 parts of momordica grosvenori, 8 parts of burdock fruit, 12 parts of ophiopogon japonicus, 5 parts of lily, 1 part of ginger, 2 parts of sodium carboxymethyl cellulose, and 7 parts of sucrose.

[0009] In an exemplary embodiment, the compound preparation is a lozenge or a spray.

[0010] The second aspect of the present application provides a method for preparing the above-mentioned compound preparation, wherein the compound preparation is a spray, and the method comprises: a) Weigh ginger according to the proportion, squeeze the juice with a juicer, let it stand and filter, collect the filtrate to obtain ginger juice; b) weighing monk fruit, burdock, ophiopogon japonicus and lily according to the proportion, crushing the monk fruit and burdock; soaking in water and then decocting, first boiling with high heat, then decocting with low heat for 20-30 min, cooling and filtering; taking the filter residue, adding water, first boiling with high heat, then decocting with low heat for 15-20 min, cooling and filtering; combining the filtrate obtained twice with the ginger juice obtained in step a), centrifuging and obtaining a centrifuge; c) weighing menthol and borneol according to the proportion, mixing and grinding until liquefied to obtain a mixed solution; d) taking the centrifuged liquid obtained in step b), adding the mixed liquid obtained in step c), lidocaine, sodium carboxymethyl cellulose and sucrose under stirring, and mixing well; e) Sterilize with UV light for 30-60 minutes and then fill the product.

[0011] Preferably, the combined solution in step b) is centrifuged at a speed of 3000-5000 r / min for 10-15 min.

[0012] Compared with the prior art, the present invention has the following technical effects: The invention uses Chinese medicine and Western medicine in combination, so that the analgesic effect is faster and the analgesic duration is longer than that of existing preparations; the invention treats the throat and lungs, eliminates inflammation of the throat and lungs while relieving pain, and allows patients to recover quickly without pain; the preparation of the invention can adhere to the inflamed part of the throat for a long time, has a longer drug release time at the inflamed part and a better therapeutic effect.

[0013] The invention also has the effects of nourishing the spleen and stomach, clearing the heart and calming the nerves, alleviating the patient's restlessness, anxiety and irritability caused by physical discomfort, improving the patient's overall health state, and enhancing the patient's immunity to reduce the probability of recurrence. DETAILED DESCRIPTION

[0014] Embodiment 1: Raw material ratio: 2 parts of lidocaine, 3 parts of borneol, 4 parts of menthol, 8 parts of monk fruit, 8 parts of burdock fruit, 10 parts of ophiopogon japonicus, 6 parts of lily, 2 parts of ginger, 2 parts of sodium carboxymethyl cellulose, and 7 parts of sucrose.

[0015] The preparation process includes the following steps: a) Weigh 2 parts of ginger according to the proportion, squeeze the juice with a juicer, let it stand and filter, collect the filtrate to obtain ginger juice; b) weighing 8 parts of Momordica grosvenori, 8 parts of Burdock seeds, 10 parts of Radix Ophiopogonis, and 6 parts of Lilium according to the proportion, and crushing the Momordica grosvenori and Burdock seeds; washing the above ingredients and placing them in a frying pan, taking 7 times the amount of water, soaking them in cold water for 30 minutes, and then decocting them, first boiling them with high heat, then decocting them with low heat for 30 minutes, and filtering them after cooling; taking the filter residue, adding 4 times the amount of water, first boiling them with high heat, then decocting them with low heat for 20 minutes, and filtering them after cooling; combining the filtrates obtained from the two times with the ginger juice obtained in step a), and centrifuging them at 3000 r / min for 10 minutes to obtain a centrifuge; c) Weigh 4 parts of menthol and 3 parts of borneol according to the ratio, put them in a mortar and grind them together until they are liquefied to obtain a mixed solution; d) taking the centrifuged liquid obtained in step b), adding the mixed liquid obtained in step c), 2 parts of lidocaine, 2 parts of sodium carboxymethyl cellulose, and 10 parts of sucrose under stirring, and mixing well; e) Sterilize with UV light for 45 minutes and then fill the product.

[0016] Embodiment 2: Raw material ratio: 3 parts of lidocaine, 2 parts of borneol, 3 parts of menthol, 11 parts of momordica grosvenori, 8 parts of burdock fruit, 12 parts of ophiopogon japonicus, 5 parts of lily, 1 part of ginger, 2 parts of sodium carboxymethyl cellulose, and 5 parts of sucrose.

[0017] The preparation process is the same as that of Example 1.

[0018] Comparative Example 1: Raw material ratio: 2 parts of lidocaine, 3 parts of borneol, 4 parts of menthol, 8 parts of monk fruit, 8 parts of burdock fruit, 10 parts of ophiopogon japonicus, 6 parts of lily, 2 parts of sodium carboxymethyl cellulose, and 7 parts of sucrose.

[0019] The preparation process is the same as that of Example 1.

[0020] Comparative Example 2: Raw material ratio: 2 parts of lidocaine, 3 parts of borneol, 4 parts of menthol, 8 parts of momordica grosvenori, 8 parts of burdock fruit, 10 parts of ophiopogon japonicus, 6 parts of lily, 5 parts of ginger, 2 parts of sodium carboxymethyl cellulose, and 7 parts of sucrose.

[0021] The preparation process is the same as that of Example 1.

[0022] Comparative Example 3: The raw material ratio is the same as that in Example 1.

[0023] Preparation process: ginger is not squeezed for juice, but is put into a frying pan together with monk fruit, burdock, ophiopogon and lily for decoction. The rest of the preparation process is the same as in Example 1, as follows.

[0024] a) Weigh 8 parts of Momordica grosvenori, 8 parts of Burdock seeds, 10 parts of Radix Ophiopogonis, 6 parts of Lilium bulbs, and 2 parts of ginger according to the proportion, crush the Momordica grosvenori and Burdock seeds, and slice the ginger; wash the above ingredients and put them in a frying pan, take 7 times the amount of water, soak them in cold water for 30 minutes, and then boil them, first boil them with high heat, then boil them with low heat for 30 minutes, and filter them after cooling; take the filter residue, add 4 times the amount of water, first boil them with high heat, then boil them with low heat for 20 minutes, and filter them after cooling; combine the filtrates obtained twice, and centrifuge them at 3000 r / min for 10 minutes to obtain the centrifuge liquid; b) Weigh 4 parts of menthol and 3 parts of borneol according to the ratio, put them in a mortar and grind them together until they are liquefied to obtain a mixed solution; c) taking the centrifuged liquid obtained in step a), adding the mixed liquid obtained in step b), 2 parts of lidocaine, 2 parts of sodium carboxymethyl cellulose, and 10 parts of sucrose under stirring, and mixing well; d) Sterilize under ultraviolet light for 45 minutes and then fill the product.

[0025] Comparative Example 4: Raw material ratio: 2 parts of lidocaine, 3 parts of borneol, 4 parts of menthol, 8 parts of monk fruit, 8 parts of burdock fruit, 10 parts of ophiopogon japonicus, 6 parts of lily, 2 parts of ginger, and 7 parts of sucrose.

[0026] Preparation process: In step d), sodium carboxymethyl cellulose is not added to the centrifuge solution, and the rest of the preparation process is the same as in Example 1.

[0027] Test 1: 30 adult patients with sore throats, each of whom used one of the samples of Example 1, Example 2, Comparative Example 1, Comparative Example 2, Comparative Example 3 and Comparative Example 4. The method of use was to spray 3 times a day, 5 times each time. Feedback information was collected, and the results were as follows:

[0028]

[0029] In the above embodiment, common symptoms of adult patients with sore throat include: patients with sore throat often feel burning or tingling in the throat, which is particularly obvious when swallowing. A throat examination shows that the throat is dark red and severely swollen, and in severe cases, there may be purulent secretions.

[0030] Patients with concurrent lung inflammation may experience difficulty breathing or shortness of breath. Patients may feel tingling or pressure in the chest and lungs, which worsens when they cough or take a deep breath. Doctors may hear additional respiratory noises in addition to the breath sounds in the lungs when listening to the stethoscope.

[0031] The onset time refers to: the patient feels that the pain in the throat is significantly relieved, at this time the temperature sensation in the throat has not disappeared, and the patient can still feel the cool feeling brought by the spray.

[0032] The time of complete effect is when the patient feels that the pain in the throat has completely disappeared.

[0033] Significant improvement compared to before medication means that redness still exists in the throat, but the swelling has significantly decreased or completely disappeared.

[0034] Complete disappearance of throat redness and swelling means: there is no abnormal redness or swelling in the throat area.

[0035] The complete disappearance of lung discomfort means: smooth breathing, no pain, no cough, no sputum, no wheezing, no chest tightness, and no abnormal sounds.

[0036] No unusual feeling means that after using the spray, there is no discomfort in the mouth and throat caused by the drug, such as tingling, burning, etc.

[0037] Similar to before medication means: the throat is dark red, with severe swelling, and may be accompanied by purulent secretions.

[0038] Throat redness and swelling are still observed, which means that the throat area is still significantly red, and the degree of swelling has slightly decreased.

[0039] The presence of wheezing sounds in the lungs during breathing refers to lung rales or wheezing sounds, that is, the presence of additional respiratory murmurs in addition to lung breath sounds.

[0040] Pain in the lungs still exists if: there is a sharp, stabbing, or constant pain that gets worse with coughing or taking a deep breath.

[0041] A noticeable burning sensation in the mouth means that the spicy and irritating taste of the spray brings a burning and tingling sensation to the mouth.

[0042] Slight redness in the throat means: Slight redness in the throat area and complete disappearance of swelling.

[0043] A slight feeling of obstruction when breathing means that when breathing in a quiet state, you sometimes feel difficulty in taking a deep breath, wheezing or shortness of breath.

[0044] Conclusion: The spray product prepared by the present invention has a faster analgesic effect and a longer analgesic duration, and has a therapeutic effect on inflammation of the throat and lungs. The patient can be basically cured after taking the medicine for 3-5 days.

[0045] Test 2: 5 children with sore throats used the sample of Example 1. The method of use was to spray 3 times a day, 3 times each time. Feedback information was collected, and the results were as follows:

[0046] Conclusion: The spray product prepared by the present invention also has a good therapeutic effect on children with sore throat, and the present invention has a good taste and flavor and is easily accepted.

Claims

1. A compound preparation for treating razor throat, characterized in that: The compound preparation is composed of the following raw materials in parts by weight: 2~4 parts of lidocaine 0.5~4 portions of borneol 0.5~4 parts of menthol 5~11 servings of monk fruit 3~9 portions of burdock seeds 6~12 servings of Ophiopogon japonicus 2~8 lilies 0.5~3 portions of ginger 1~5 parts of sodium carboxymethyl cellulose 3~8 parts of sucrose.

2. A compound preparation for treating razor throat according to claim 1, characterized in that: The compound preparation is composed of the following raw materials in parts by weight: 2 parts of lidocaine, 3 parts of borneol, 4 parts of menthol, 8 parts of momordica grosvenori, 8 parts of burdock seeds, 10 parts of ophiopogon japonicus, 6 parts of lily, 2 parts of ginger, 2 parts of sodium carboxymethyl cellulose, and 7 parts of sucrose.

3. A compound preparation for treating razor throat according to claim 1, characterized in that: The compound preparation is composed of the following raw materials in parts by weight: 3 parts of lidocaine, 2 parts of borneol, 3 parts of menthol, 11 parts of momordica grosvenori, 8 parts of burdock seeds, 12 parts of ophiopogon japonicus, 5 parts of lily, 1 part of ginger, 2 parts of sodium carboxymethyl cellulose, and 5 parts of sucrose.

4. The compound preparation for treating razor throat according to claim 1, characterized in that: The compound preparation is in the form of oral lozenges or sprays.

5. The method for preparing a compound preparation for treating razor throat according to claim 1, characterized in that: The compound preparation is a spray, and the method is: a) Weigh ginger according to the proportion, squeeze the juice with a juicer, let it stand and filter, collect the filtrate to obtain ginger juice; b) weighing monk fruit, burdock, ophiopogon japonicus and lily according to the proportion, crushing the monk fruit and burdock; soaking in water and then decocting, first boiling with high heat, then decocting with low heat for 20-30 min, cooling and filtering; taking the filter residue, adding water, first boiling with high heat, then decocting with low heat for 15-20 min, cooling and filtering; combining the filtrate obtained twice with the ginger juice obtained in step a), centrifuging and obtaining a centrifuge; c) weighing menthol and borneol according to the proportion, mixing and grinding until liquefied to obtain a mixed solution; d) taking the centrifuged liquid obtained in step b), adding the mixed liquid obtained in step c), lidocaine, sodium carboxymethyl cellulose and sucrose under stirring, and mixing well; e) Sterilize with UV light for 30-60 minutes and then fill the product.

6. The method for preparing a compound preparation for treating razor throat according to claim 5, characterized in that: The combined solution in step b) is centrifuged at a speed of 3000-5000 r / min for 10-15 min.

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