Preparation process and equipment of traditional Chinese medicine external preparation compound safflower tincture for treating alopecia

Abstract

The invention relates to the technical field of external preparations, in particular to a preparation process and equipment of a traditional Chinese medicine external preparation compound safflower tincture for treating alopecia, and the preparation process comprises the following steps: S1, grinding a plurality of raw materials into powder, and mixing the powder into a dry material; s2, extracting extracts of a plurality of materials to obtain a mixed extract; s3, mixing the dry material and the mixed extract in water at a preset temperature for a preset time to obtain a mixed solution; s4, heating the mixed solution to a preset extraction temperature, maintaining preset extraction time, and mixing the mixed solution with ethanol to obtain an extract; s5, determining the qualification of the extract liquor based on the color evaluation value of the extract liquor; s6, determining the qualification of the adjusted extraction liquid based on the light transmittance of the adjusted extraction liquid; and step S7, mixing the optimized extract with olive oil to obtain the safflower tincture. The preparation efficiency of the safflower tincture is improved.

Description

Technical Field

[0001] The invention relates to the technical field of external preparations, in particular to a preparation process and equipment of a traditional Chinese medicine external preparation compound safflower tincture for treating alopecia. Background Art

[0002] According to TCM theory, hair loss is related to various syndromes such as insufficient qi and blood, liver and kidney deficiency, and wind caused by heat in the blood. The hair loss condition can be fundamentally improved through overall conditioning. The Chinese medicine external preparation compound safflower tincture is based on the traditional TCM theory. It can promote scalp blood circulation, improve the nutrient supply of hair follicles, regulate the oil secretion of the scalp, inhibit inflammation of hair follicles, and stimulate the regeneration of hair follicle cells. The external use of Chinese medicine is relatively safe, with fewer side effects, and is suitable for long-term use.

[0003] Chinese patent application publication number: CN115120698A discloses an anti-hair loss external Chinese medicine composition and a preparation method thereof, comprising: sophora flavescens, white peony root, Kochia scoparia, Platycladus orientalis leaf, mulberry leaf, Smilax glabra, Stemona tuber, Pinellia tuber, Acorus calamus, Atractylodes macrocephala, Ligusticum chuanxiong, Angelica sinensis, Millettia spatholobi, safflower, peony bark, red peony root, lithospermum officinale, Saposhnikovia divaricata, Notopterygium wilfordii, Vitex rotundifolia, Angelica dahurica, Plantago asiatica, Alisma orientalis, Eclipta prostrata, Polygonum multiflorum, Bupleurum chinense, Cinnamomum cassia, dried ginger, Zanthoxylum bungeanum, Psoralea corylifolia, Epimedium brevicornum, Licorice, and Mentha. However, the prior art has the following problems: the prior art does not monitor the extraction and other steps in the preparation process of safflower tincture, resulting in unstable quality of safflower tincture preparation, thereby resulting in low preparation efficiency of safflower tincture. Summary of the invention

[0004] To this end, the present invention provides a preparation process and equipment of a traditional Chinese medicine external preparation compound safflower tincture for treating hair loss, so as to overcome the problem of low preparation efficiency of safflower tincture in the prior art.

[0005] To achieve the above object, the present invention provides a preparation process and equipment of a Chinese medicine external preparation compound safflower tincture for treating hair loss, comprising:

[0006] Step S1, grinding a number of raw materials into powder and mixing them into dry materials, wherein the raw materials include Polygonum multiflorum, Astragalus, Cortex Moutan and Rhizoma Chuanxiong;

[0007] Step S2, extracting extracts of several materials to obtain a mixed extract, wherein the materials include safflower, arborvitae leaves, mulberry fruits, and lycium bark;

[0008] Step S3, mixing the dry material and the mixed extract in water at a preset temperature for a preset time to obtain a mixed solution;

[0009] Step S4, heating the mixed solution to a preset extraction temperature and maintaining the temperature for a preset extraction time, and then mixing the mixed solution with ethanol to obtain an extract;

[0010] Step S5, determining the eligibility of the extract based on the color evaluation value of the extract, and if the extract is determined to be unqualified, determining to increase the preset extraction temperature or increase the preset extraction time according to the ratio of the color evaluation value to the preset color evaluation value;

[0011] Step S6, determining the eligibility of the adjusted extract based on the transmittance of the adjusted extract, and if the adjusted extract is determined to be unqualified, determining to increase the preset temperature or increase the preset time according to the difference between the preset transmittance and the transmittance to optimize the extraction conditions;

[0012] Step S7, mixing the optimized extract with olive oil to obtain safflower tincture.

[0013] Furthermore, in step S3, the preset temperature range is 60°C-75°C, and the preset time is 2 hours.

[0014] Furthermore, in step S4, the preset extraction temperature range is 60° C.-80° C., and the preset extraction time is 5 hours.

[0015] Furthermore, in step S5, the extract is determined to be unqualified based on the comparison result that the color evaluation value of the extract is less than or equal to a preset color evaluation value.

[0016] Further, under the condition that the extract is determined to be unqualified, the preset extraction temperature is increased by a preset extraction temperature adjustment coefficient based on a comparison result that the ratio of the color evaluation value to the preset color evaluation value is less than or equal to the preset ratio.

[0017] Further, under the condition that the extract is determined to be unqualified, based on the comparison result that the ratio of the color evaluation value to the preset color evaluation value is greater than the preset ratio, it is determined to increase the preset extraction time by a preset extraction time adjustment coefficient.

[0018] Furthermore, in step S6, the adjusted extract is determined to be unqualified based on the comparison result that the transmittance of the adjusted extract is less than or equal to the preset transmittance.

[0019] Further, under the condition that the adjusted extract is determined to be unqualified, it is determined to increase the preset temperature by a preset temperature adjustment coefficient based on a comparison result that the preset transmittance and the transmittance difference are less than or equal to the preset difference.

[0020] Further, under the condition that the adjusted extract is determined to be unqualified, based on the comparison result that the difference between the preset transmittance and the transmittance is greater than the preset difference, it is determined to increase the preset time by the preset time adjustment coefficient.

[0021] Furthermore, a preparation device for a Chinese medicine external preparation compound safflower tincture for treating hair loss comprises:

[0022] A shell, comprising a first feed port disposed at the upper portion of the shell for conveying raw materials, a grinding layer disposed near the bottom end of the first feed port for grinding the raw materials, a screen disposed at the lower side of the grinding layer for screening dry materials, a second feed port disposed at the side of the shell near the screen for conveying mixed extracts, a first mixing chamber disposed at the lower side of the screen for mixing the dry materials and the mixed extracts, a filter disposed at the lower side of the first mixing chamber for filtering the mixed solution, an extraction chamber disposed at the lower side of the filter for extracting the mixed solution, a discharge port disposed at one side of the lower portion of the shell near the extraction chamber for outputting extracted extracts, and an optical sensor disposed on the inner side wall of the extraction chamber for detecting color and transmittance information of the extracts;

[0023] The tank body comprises a third feed port arranged on one side of the upper part of the tank body for conveying olive oil, the discharge port arranged on one side of the upper part of the can head near the third feed port, and a second mixing chamber arranged inside the tank body for mixing the extracted extract and the olive oil.

[0024] Compared with the prior art, the beneficial effect of the present invention lies in that the quality of the safflower tincture is ensured, the purity of the safflower tincture is improved, and the efficiency of the preparation of the safflower tincture is improved by crushing and mixing the traditional Chinese medicine, extracting other material components, mixing, extracting and adjusting process parameters, and finally combining with olive oil to make safflower tincture.

[0025] Furthermore, the present invention ensures the stability and controllability of the mixing and extraction processes by controlling the temperature and duration parameters of the mixing and extraction processes, thereby further improving the preparation efficiency of safflower tincture.

[0026] Furthermore, the present invention determines whether the extract is qualified by comparing the color evaluation value with a preset color evaluation value. If it is unqualified, the mixed solution is adjusted based on the comparison result of the ratio of the color evaluation value to the preset color evaluation value and the preset ratio, thereby ensuring the qualification of the color of the extract, optimizing the extraction effect by adjusting the extraction conditions, and improving the preparation efficiency.

[0027] Furthermore, the present invention compares the preset transmittance with the difference between the transmittance and the preset difference to decide whether to increase the preset temperature or increase the preset time to optimize the mixed solution, accurately adjust the extraction conditions, ensure that the quality of the extract meets the standards, and improve the preparation efficiency and the stability of the quality of safflower tincture. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 The flowchart is a process for preparing the compound safflower tincture of the traditional Chinese medicine for external use for treating hair loss according to an embodiment of the present invention;

[0029] Figure 2 It is a schematic structural diagram of a device for preparing a Chinese medicine external preparation compound safflower tincture for treating hair loss according to an embodiment of the present invention;

[0030] Figure 3 A flow chart for determining the eligibility of an extract according to an embodiment of the present invention;

[0031] Figure 4 A flow chart for determining the eligibility of the adjusted extract according to an embodiment of the present invention;

[0032] In the figure, 1. shell; 2. first feed port; 3. grinding layer; 4. screen; 5. second feed port; 6. first mixing chamber; 7. filter; 8. extraction chamber; 9. discharge port; 10. third feed port; 11. tank body; 12. second mixing chamber; 13. optical sensor. DETAILED DESCRIPTION

[0033] In order to make the objects and advantages of the present invention more clearly understood, the present invention is further described below in conjunction with embodiments; it should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0034] The preferred embodiments of the present invention are described below with reference to the accompanying drawings. It should be understood by those skilled in the art that these embodiments are only used to explain the technical principles of the present invention and are not intended to limit the protection scope of the present invention.

[0035] It should be pointed out that the data in this embodiment are obtained by comprehensive analysis and evaluation of the historical test data and the corresponding historical test results of the present invention in the three months before this test. It can be understood by those skilled in the art that the present invention can determine the above parameters for a single item by selecting the highest proportion of values ​​as the preset standard parameters according to the data distribution, using weighted summation to use the obtained values ​​as the preset standard parameters, substituting each historical data into a specific formula and using the values ​​obtained by the formula as the preset standard parameters or other selection methods, as long as the present invention can clearly define different specific situations in the single determination process through the obtained values.

[0036] See also Figure 1 - Figure 4 As shown, Figure 1 The flowchart is a process for preparing the compound safflower tincture of the traditional Chinese medicine for external use for treating hair loss according to an embodiment of the present invention; Figure 2 It is a schematic structural diagram of a device for preparing a Chinese medicine external preparation compound safflower tincture for treating hair loss according to an embodiment of the present invention; Figure 3 A flow chart for determining the eligibility of an extract according to an embodiment of the present invention; Figure 4 The flowchart of determining the eligibility of the adjusted extract according to the embodiment of the present invention.

[0037] The preparation process of the compound safflower tincture of the traditional Chinese medicine external preparation for treating hair loss according to the embodiment of the present invention comprises:

[0038] Step S1, grinding a number of raw materials into powder and mixing them into dry materials, wherein the raw materials include Polygonum multiflorum, Astragalus, Cortex Moutan and Rhizoma Chuanxiong;

[0039] Step S2, extracting extracts of several materials to obtain a mixed extract, wherein the materials include safflower, arborvitae leaves, mulberry fruits, and lycium bark;

[0040] Step S3, mixing the dry material and the mixed extract in water at a preset temperature for a preset time to obtain a mixed solution;

[0041] Step S4, heating the mixed solution to a preset extraction temperature and maintaining the temperature for a preset extraction time, and then mixing the mixed solution with ethanol to obtain an extract;

[0042] Step S5, determining the eligibility of the extract based on the color evaluation value of the extract, and if the extract is determined to be unqualified, determining to increase the preset extraction temperature or increase the preset extraction time according to the ratio of the color evaluation value to the preset color evaluation value;

[0043] Step S6, determining the eligibility of the adjusted extract based on the transmittance of the adjusted extract, and if the adjusted extract is determined to be unqualified, determining to increase the preset temperature or increase the preset time according to the difference between the preset transmittance and the transmittance to optimize the extraction conditions;

[0044] Step S7, mixing the optimized extract with olive oil to obtain safflower tincture.

[0045] The embodiment of the present invention provides a preparation device of a Chinese medicine external preparation compound safflower tincture for treating hair loss, comprising:

[0046] A shell 1, comprising a first feed port 2 arranged at the upper part of the shell 1 for conveying raw materials, a grinding layer 3 arranged near the bottom of the first feed port 2 for grinding raw materials, a screen 4 arranged at the lower side of the grinding layer 3 for screening dry materials, a second feed port 5 arranged at the side of the shell 1 near the screen 4 for conveying mixed extracts, a first mixing chamber 6 arranged at the lower side of the screen 4 for mixing the dry materials and the mixed extracts, a filter 7 arranged at the lower side of the first mixing chamber 6 for filtering the mixed solution, an extraction chamber 8 arranged at the lower side of the filter 7 for extracting the mixed solution, a discharge port 9 arranged at one side of the lower part of the shell 1 near the extraction chamber 8 for outputting the extracted extract, and an optical sensor 13 arranged on the inner side wall of the extraction chamber 8 for detecting the color and transmittance information of the extract;

[0047] The tank body 11 includes a third feed port 10 for conveying olive oil, which is arranged on one side of the upper part of the tank body 11, the discharge port 9 is arranged on one side of the upper part of the can near the third feed port 10, and a second mixing chamber 12 is arranged inside the tank body 11 for mixing the extracted extract and the olive oil.

[0048] In the embodiment of the present invention, 50g of Polygonum multiflorum, 30g of Astragalus, 20g of Moutan bark, 20g of Chuanxiong, 30g of Carthamus tinctorius, 25g of Platycladus orientalis leaves, 25g of mulberry fruit, 20g of Lycium bark, 100g of olive oil, 500ml of 75% ethanol, and 1000ml of water.

[0049] Specifically, the present invention grinds and mixes traditional Chinese medicine, extracts other material components, mixes, extracts and adjusts process parameters, and finally combines with olive oil to prepare safflower tincture, thereby ensuring the quality of safflower tincture, improving the purity of safflower tincture and improving the efficiency of preparing safflower tincture.

[0050] Specifically, in step S3, the preset temperature range is 60°C-75°C, and the preset time is 2 hours.

[0051] Specifically, in step S4, the preset extraction temperature range is 60° C.-80° C., and the preset extraction time is 5 hours.

[0052] Specifically, the present invention ensures the stability and controllability of the mixing and extraction processes by controlling the temperature and duration parameters of the mixing and extraction processes, and further improves the preparation efficiency of safflower tincture.

[0053] Specifically, after the extract is determined to be obtained, the eligibility of the extract is determined according to the comparison result between the color evaluation value of the extract and the preset color evaluation value;

[0054] When the color evaluation value is less than or equal to the preset color evaluation value, the extract is determined to be unqualified;

[0055] When the color evaluation value is greater than the preset color evaluation value, it is determined that the extract is qualified.

[0056] In the embodiment of the present invention, the preset color evaluation value is 0.86, but the above value is not limited thereto, and those skilled in the art may also adjust the value according to actual needs.

[0057] Specifically, the color evaluation value is the ratio of the actual color saturation of the extract to the color saturation of the qualified extract multiplied by the ratio of the actual brightness of the extract to the brightness of the qualified extract, wherein the actual color saturation and brightness of the extract are measured by an optical sensor, and the color saturation and brightness of the qualified extract are the average of the qualified values ​​measured by historical experiments.

[0058] Specifically, under the condition that the extract is determined to be unqualified, the adjustment method of the mixed solution is determined according to the comparison result of the ratio of the color evaluation value to the preset color evaluation value and the preset ratio;

[0059] When the ratio is less than or equal to the preset ratio, it is determined that the preset extraction temperature is increased to a corresponding value by a preset extraction temperature adjustment coefficient of 1.03;

[0060] When the ratio is greater than the preset ratio, it is determined that the preset extraction time is increased to a corresponding value by a preset extraction time adjustment coefficient of 1.07;

[0061] The ratio is a ratio of the color evaluation value to a preset color evaluation value.

[0062] In the embodiment of the present invention, the preset ratio is 0.75, but the above value is not limited thereto, and those skilled in the art may also adjust the value according to actual needs.

[0063] In the embodiment of the present invention, the increased preset extraction temperature is the product of the preset extraction temperature and the preset extraction temperature adjustment coefficient of 1.03, and the increased preset extraction time is the product of the preset extraction time and the preset extraction time adjustment coefficient of 1.07.

[0064] Specifically, the present invention determines whether the extract is qualified by comparing the color evaluation value with the preset color evaluation value. If it is unqualified, it decides to adjust the mixed solution based on the comparison result of the ratio of the color evaluation value to the preset color evaluation value and the preset ratio, thereby ensuring the qualification of the color of the extract, optimizing the extraction effect by adjusting the extraction conditions, and improving the preparation efficiency.

[0065] Specifically, the eligibility of the adjusted extract is determined based on a comparison result between the transmittance of the adjusted extract and a preset transmittance;

[0066] When the transmittance is less than or equal to the preset transmittance, the adjusted extract is determined to be unqualified;

[0067] When the transmittance is greater than the preset transmittance, it is determined that the adjusted extract is qualified.

[0068] In the embodiment of the present invention, the preset transmittance value is 80%, but the above value is not limited thereto, and those skilled in the art may also adjust the value according to actual needs.

[0069] Specifically, the transmittance is the ratio of the transmitted light intensity to the incident light intensity in the extract, and the transmitted light intensity and the incident light intensity are measured by the optical sensor.

[0070] Specifically, under the condition that the adjusted extract is determined to be unqualified, an optimization method of the mixed solution is determined based on a comparison result between a preset transmittance and a difference between the transmittance and a preset difference;

[0071] When the difference is less than or equal to the preset difference, it is determined to increase the preset temperature to a corresponding value by a preset temperature adjustment coefficient of 1.05;

[0072] When the difference is greater than the preset difference, it is determined to increase the preset duration to a corresponding value by a preset duration adjustment coefficient of 1.09;

[0073] The difference is the difference between the preset transmittance and the transmittance.

[0074] In the embodiment of the present invention, the preset difference value is 0.58, but the above value is not limited thereto, and those skilled in the art may also adjust the value according to actual needs.

[0075] In the embodiment of the present invention, the increased preset temperature is the product of the preset temperature and the preset temperature adjustment coefficient 1.05, and the increased preset duration is the product of the preset duration and the preset duration adjustment coefficient 1.09.

[0076] Specifically, the present invention compares the preset transmittance with the difference between the transmittance and the preset difference to decide whether to increase the preset temperature or increase the preset time to optimize the mixed solution, accurately adjust the extraction conditions, ensure that the quality of the extract meets the standards, and improve the preparation efficiency and the stability of the quality of safflower tincture.

[0077] So far, the technical solutions of the present invention have been described in conjunction with the preferred embodiments shown in the accompanying drawings. However, it is easy for those skilled in the art to understand that the protection scope of the present invention is obviously not limited to these specific embodiments. Without departing from the principle of the present invention, those skilled in the art can make equivalent changes or substitutions to the relevant technical features, and the technical solutions after these changes or substitutions will fall within the protection scope of the present invention.

[0078] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A preparation process of a Chinese medicine external preparation compound safflower tincture for treating hair loss, characterized in that: include: Extracts Step S1, grinding a number of raw materials into powder and mixing them into dry materials, wherein the raw materials include Polygonum multiflorum, Astragalus, Cortex Moutan and Rhizoma Chuanxiong; Step S2, extracting extracts of several materials to obtain a mixed extract, wherein the materials include safflower, arborvitae leaves, mulberry fruits, and lycium bark; Step S3, mixing the dry material and the mixed extract in water at a preset temperature for a preset time to obtain a mixed solution; Step S4, heating the mixed solution to a preset extraction temperature and maintaining the temperature for a preset extraction time, and then mixing the mixed solution with ethanol to obtain an extract; Step S5, determining the eligibility of the extract based on the color evaluation value of the extract, and if the extract is determined to be unqualified, determining to increase the preset extraction temperature or increase the preset extraction time according to the ratio of the color evaluation value to the preset color evaluation value; Step S6, determining the eligibility of the adjusted extract based on the transmittance of the adjusted extract, and if the adjusted extract is determined to be unqualified, determining to increase the preset temperature or increase the preset time according to the difference between the preset transmittance and the transmittance to optimize the extraction conditions; Step S7, mixing the optimized extract with olive oil to obtain safflower tincture.

2. The preparation process of the compound safflower tincture of the Chinese medicinal external preparation for treating hair loss according to claim 1, characterized in that: In step S3, the preset temperature range is 60°C-75°C, and the preset time is 2 hours.

3. The preparation process and equipment of the compound safflower tincture of the traditional Chinese medicine for external use for treating hair loss according to claim 1, characterized in that: In step S4, the extraction temperature is preset to range from 60° C. to 80° C., and the extraction time is preset to be 5 hours.

4. The preparation process of the compound safflower tincture of the Chinese medicinal external preparation for treating hair loss according to claim 1, characterized in that: In the step S5, the extract is determined to be unqualified based on the comparison result that the color evaluation value of the extract is less than or equal to the preset color evaluation value.

5. The preparation process of the compound safflower tincture of the Chinese medicinal external preparation for treating hair loss according to claim 4, characterized in that: Under the condition that the extract is determined to be unqualified, the preset extraction temperature is increased by a preset extraction temperature adjustment coefficient based on a comparison result that the ratio of the color evaluation value to the preset color evaluation value is less than or equal to the preset ratio.

6. The preparation process of the compound safflower tincture of the Chinese medicinal external preparation for treating hair loss according to claim 4, characterized in that: Under the condition that the extract is determined to be unqualified, based on a comparison result that the ratio of the color evaluation value to the preset color evaluation value is greater than the preset ratio, it is determined that the preset extraction time is increased by a preset extraction time adjustment coefficient.

7. The preparation process of the compound safflower tincture of the Chinese medicinal external preparation for treating hair loss according to claim 1, characterized in that: In the step S6, the adjusted extract is determined to be unqualified based on the comparison result that the transmittance of the adjusted extract is less than or equal to the preset transmittance.

8. The preparation process of the compound safflower tincture of the Chinese medicinal external preparation for treating hair loss according to claim 7, characterized in that: Under the condition that the adjusted extract is determined to be unqualified, the preset temperature is increased by the preset temperature adjustment coefficient based on a comparison result that the preset transmittance and the transmittance difference are less than or equal to the preset difference.

9. The preparation process of the compound safflower tincture of the Chinese medicinal external preparation for treating hair loss according to claim 7, characterized in that: Under the condition that the adjusted extract is determined to be unqualified, based on the comparison result that the difference between the preset transmittance and the transmittance is greater than the preset difference, it is determined to increase the preset time by the preset time adjustment coefficient.

10. A preparation device for a Chinese medicine external preparation compound safflower tincture for treating hair loss, characterized in that: include: A shell, comprising a first feed port disposed at the upper portion of the shell for conveying raw materials, a grinding layer disposed near the bottom end of the first feed port for grinding the raw materials, a screen disposed at the lower side of the grinding layer for screening dry materials, a second feed port disposed at the side of the shell near the screen for conveying mixed extracts, a first mixing chamber disposed at the lower side of the screen for mixing the dry materials and the mixed extracts, a filter disposed at the lower side of the first mixing chamber for filtering the mixed solution, an extraction chamber disposed at the lower side of the filter for extracting the mixed solution, a discharge port disposed at one side of the lower portion of the shell near the extraction chamber for outputting extracted extracts, and an optical sensor disposed on the inner side wall of the extraction chamber for detecting color and transmittance information of the extracts; The tank body comprises a third feed port arranged on one side of the upper part of the tank body for conveying olive oil, the discharge port arranged on one side of the upper part of the can head near the third feed port, and a second mixing chamber arranged inside the tank body for mixing the extracted extract and the olive oil.

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