Traditional Chinese medicine composition for treating recurrent oral ulceration, emplastrum and preparation method

Abstract

The invention relates to the technical field of traditional Chinese medicine plasters, in particular to a traditional Chinese medicine composition for treating recurrent oral ulceration, an emplastrum and a preparation method. The invention discloses a traditional Chinese medicine composition for treating recurrent oral ulceration through application, which is prepared from the following raw materials in parts by weight: 8-12 parts of earthworm, 8-12 parts of fructus evodiae, 8-12 parts of rheum officinale, 8-12 parts of coptis chinensis, 6-10 parts of asarum, 8-12 parts of clove and 8-12 parts of mung bean. The traditional Chinese medicine composition provided by the invention is derived from 'Yuhongshin', is prepared by finishing, and has the effects of guiding fire to origin, clearing away heat, clearing away heart-fire and promoting wound healing. The traditional Chinese medicine is attached to the Shenque acupoint in the navel and the Yongquan acupoint in the sole center, so that the recurrent oral ulceration can be effectively relieved and treated.

Description

Technical Field

[0001] The invention relates to the technical field of Chinese medicine plasters, and more specifically to a Chinese medicine composition for applying and treating recurrent oral ulcers, a plaster and a preparation method. Background Art

[0002] Recurrent oral ulcer (ROU) is the most common oral mucosal disease with the highest incidence rate in clinical practice. It has obvious recurrence and self-limitation characteristics. It mainly occurs in the non-keratinized oral mucosal epithelium. The main group of patients is young and middle-aged people, and the prevalence rate can be as high as 20%. It is mainly manifested as superficial oval or round ulcers on the oral mucosa. The center of the lesion is sunken, the surrounding area is red and swollen, and the surface is covered with gray-yellow or gray-white pseudomembranes. When exposed to external stimuli, it will cause severe burning pain, which has a serious impact on daily eating and speech. Modern medicine has not yet clarified the cause of the disease. It is generally believed that it is related to genetic factors, abnormal immune function, trace element deficiency, local microcirculation disorders, etc. The disease recurs repeatedly, and the course of the disease is difficult to cure, which causes great distress to patients.

[0003] In traditional Chinese medicine, the main cause of recurrent oral ulcers is heat accumulation in the heart and spleen or coldness in the spleen and stomach with latent fire. The treatment is to clear away heat and dampness, disperse fire and strengthen the spleen, and use internal or external treatment. Internal treatment is oral Chinese medicine treatment, and external treatment is mostly in the form of powder. Both methods have certain limitations. Internal treatment requires daily medication; traditional external treatment is mostly targeted at local ulcer surfaces, causing greater pain to patients. Therefore, according to the theory of traditional Chinese medicine for treating upper diseases from the lower part, using plasters to treat areas far away from the affected area, such as the soles of the feet and the navel, has become a good choice.

[0004] Therefore, the present invention provides a plaster for treating recurrent oral ulcers to solve the above problems. Summary of the invention

[0005] The object of the present invention is to provide a plaster for treating recurrent oral ulcers to solve the problems raised in the above background technology.

[0006] Specifically, the present invention provides a traditional Chinese medicine composition for treating recurrent oral ulcers, comprising the following raw materials in parts by weight: 8-12 parts of earthworm, 8-12 parts of evodia rutaecarpa, 8-12 parts of rhubarb, 8-12 parts of coptis chinensis, 6-10 parts of asarum, 8-12 parts of cloves, and 8-12 parts of mung beans.

[0007] Furthermore, the preparation method comprises the following raw materials in parts by weight: 10 parts of earthworm, 10 parts of evodia rutaecarpa, 10 parts of rhubarb, 10 parts of coptis chinensis, 8 parts of asarum, 10 parts of cloves and 10 parts of mung beans.

[0008] The present invention also provides a Chinese medicine patch for treating recurrent oral ulcers, comprising the Chinese medicine composition described in the above scheme and vinegar.

[0009] The present invention also provides a method for preparing a Chinese medicine patch for treating recurrent oral ulcers, comprising the following steps: taking the above 6 Chinese medicines, crushing them into fine powder, adding vinegar and water to make a paste, making the paste into a round medicine cake with a diameter of 3 cm and a thickness of 0.2 cm, and adhering the cake to a non-woven fabric to make a plaster.

[0010] The present invention also provides a Chinese medicine plaster gel for treating recurrent oral ulcers, comprising a raw material drug, a matrix, a backing material and a protective film, wherein the raw material drug is the Chinese medicine composition described in the above scheme; the matrix comprises: NP-700, aluminum glycolate, tartaric acid, glycerol, kaolin, and purified water; the backing material is a non-woven fabric; and the protective film is an embossed film.

[0011] Furthermore, the raw material medicine includes the following raw materials in parts by weight: 10 parts of earthworm, 10 parts of Evodia rutaecarpa, 10 parts of rhubarb, 10 parts of coptis chinensis, 8 parts of asarum, 10 parts of cloves, and 10 parts of mung beans.

[0012] Furthermore, the matrix includes the following raw materials in parts by weight: 80 parts of NP-700, 3.2 parts of aluminum glycolate, 2.6 parts of tartaric acid, 288 parts of glycerol, 64 parts of kaolin, and 150 parts of purified water.

[0013] The present invention also provides a method for preparing a Chinese medicine plaster gel for treating recurrent oral ulcers, comprising the following steps:

[0014] S1: Grind the above raw materials to obtain medicinal powder.

[0015] S2: Weigh tartaric acid, add purified water and stir until completely dissolved, as the aqueous phase.

[0016] S3: Weigh aluminum glycolate, NP-700, and kaolin into an evaporating dish and mix, add glycerol and volatile oil sample and stir evenly to prepare the oil phase.

[0017] S4: Add the water phase and medicinal powder to the oil phase and heat at 60 r min -1 Stir at high speed to obtain a gel.

[0018] S5: Place the gel on a non-woven fabric and cover it with an embossed film for coating, and place it at room temperature to form.

[0019] The present invention is based on the method of "taking Lianxin in the navel, and applying Yuanyu and Dinghuang to the feet" in "Liyu Pianwen". Among the drugs used, Evodia rutaecarpa is good at treating mouth sores. "Compendium of Materia Medica" records that it can "relieve depression and resolve stagnation, treat acid regurgitation, headache due to phlegm in the Jueyin meridians, abdominal pain due to yin poison, hernia, bloody dysentery, and mouth sores in the throat and tongue"; Asarum is good at dispersing stagnant heat and floating fire, and applying it to acupoints such as Shenque and Yongquan has the effect of guiding fire downward; Clove enters the liver, spleen, stomach and kidney meridians, and has the effects of warming the middle and dispersing cold, descending adverse reactions and stopping vomiting, and promoting qi and eliminating stagnation. Applying it to Shenque can warm and unblock the internal organs, raise the clear and lower the turbid, and regulate the qi mechanism; Coptis chinensis is bitter and cold and enters the heart, clears the heart and reduces fire. The above Chinese medicines jointly play the role of guiding fire back to the origin. Rhubarb is bitter and cold, and can be used externally to purge heat and detoxify, cool blood and reduce swelling; mung bean is sweet and cold, and can clear away heat and detoxify, and is used to treat swelling and pain caused by heat toxins; modern research has confirmed that earthworms have the effects of clearing heat and detoxifying, anti-inflammatory and analgesic, and promoting blood circulation and unblocking collaterals, and can promote wound healing and enhance immunity.

[0020] It should also be noted that the recurrent oral ulcer patch prepared by the present invention has the effects of guiding fire back to the origin, venting heat and clearing the heart. The method of use is: apply the patch to the patient's Shenque point and Yongquan point before going to bed at night, and remove it in the morning. One course of treatment is 5 days. DETAILED DESCRIPTION

[0021] In order to enable those skilled in the art to better understand the solution of the present invention, the technical solution of the present invention will be further described in detail below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in the field without creative work should fall within the scope of protection of the present invention.

[0022] It should be noted that, in the absence of conflict, the embodiments and features of the embodiments of the present invention can be combined with each other. The present invention will be described in detail below in conjunction with the embodiments.

[0023] Embodiment 1

[0024] The recurrent oral ulcer patch is prepared from 10 parts of earthworms, 10 parts of evodia rutaecarpa, 10 parts of rhubarb, 10 parts of coptis chinensis, 8 parts of asarum, 10 parts of cloves and 10 parts of mung beans by weight.

[0025] Preparation method: Take the above 6 Chinese medicines, crush them into fine powder, add vinegar and water to make a paste, make it into a round medicine cake with a diameter of 3 cm and a thickness of 0.2 cm, adhere it to a non-woven fabric, and make it into a plaster.

[0026] Embodiment 2

[0027] The Chinese medicine plaster gel for recurrent oral ulcer is prepared from 10 parts of earthworm, 10 parts of evodia rutaecarpa, 10 parts of rhubarb, 10 parts of coptis chinensis, 8 parts of asarum, 10 parts of cloves and 10 parts of mung beans as raw materials, 80 parts of NP-700, 3.2 parts of aluminum glycolate, 2.6 parts of tartaric acid, 288 parts of glycerol, 64 parts of kaolin and 150 parts of purified water as a matrix, non-woven fabric as a backing material and an embossed film as a protective film.

[0028] Preparation method

[0029] S1: Grind the above raw materials to obtain medicinal powder.

[0030] S2: Weigh tartaric acid, add purified water and stir until completely dissolved, as the aqueous phase.

[0031] S3: Weigh aluminum glycolate, NP-700, and kaolin into an evaporating dish and mix, add glycerol and volatile oil sample and stir evenly to prepare the oil phase.

[0032] S4: Add the water phase to the oil phase while stirring at 60 r min -1 Stir at high speed to obtain a gel.

[0033] S5: Place the gel on a non-woven fabric and cover it with an embossed film for coating, and place it at room temperature to form.

[0034] Clinical Case 1

[0035] Patient female, 19 years old, student, had recurrent oral ulcer for many years, pain. The ulcer healing time is long, mostly more than 1 week. Use the patch prepared in Example 1 to apply to the navel Shenque point and the center of the foot Yongquan point, once every night, peel off in the morning, and the course of treatment is 5 days. After 1 day of use, the ulcer surface becomes smaller, the pain is relieved, and the ulcer surface is completely healed after 4 days. There is no recurrence in the subsequent 3 months.

[0036] Clinical Case 2

[0037] Patient female, 20 years old, student, oral ulcer recurred for 7 years, the number of ulcers was mostly 1-3, healing time 1-2 weeks. Use the gel patch prepared in Example 2 to apply to the navel Shenque point and the foot Yongquan point once a night, peel off in the morning, and the course of treatment is 5 days. After 5 days of use, the ulcer surface healed and there was no recurrence in the subsequent six months.

Claims

1. A Chinese medicine composition for treating recurrent oral ulcers, characterized in that: The invention comprises the following raw materials in parts by weight: 8-12 parts of earth dragon, 8-12 parts of evodia rutaecarpa, 8-12 parts of rhubarb, 8-12 parts of coptis root, 6-10 parts of asarum, 8-12 parts of cloves and 8-12 parts of mung beans.

2. The Chinese medicine composition according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 10 parts of earthworms, 10 parts of evodia rutaecarpa, 10 parts of rhubarb, 10 parts of coptis root, 8 parts of asarum, 10 parts of cloves and 10 parts of mung beans.

3. Use of the Chinese medicine composition according to claim 1 or 2 in the preparation of an external medicine for treating recurrent oral ulcers.

4. A Chinese medicine patch for treating recurrent oral ulcers, characterized in that: The invention comprises the Chinese medicine composition according to claim 1 or 2 and vinegar.

5. The method for preparing the Chinese medicine plaster according to claim 4, characterized in that: The method comprises the following steps: taking the above 6 traditional Chinese medicines, crushing them into fine powder, adding vinegar and water to make a paste, making the paste into a round medicine cake with a diameter of 3 cm and a thickness of 0.2 cm, adhering the cake onto a non-woven fabric, and making a plaster.

6. A Chinese medicine plaster gel for treating recurrent oral ulcers, characterized in that: The invention comprises a raw material medicine, a matrix, a backing material and a protective film, wherein the raw material medicine is the traditional Chinese medicine composition described in the above scheme; the matrix comprises: NP-700, aluminum glycolate, tartaric acid, glycerol, kaolin and purified water; the backing material is a non-woven fabric; and the protective film is an embossed film.

7. The Chinese medicine plaster gel according to claim 6, characterized in that: The matrix comprises the following raw materials in parts by weight: 80 parts of NP-700, 3.2 parts of aluminum glycolate, 2.6 parts of tartaric acid, 288 parts of glycerol, 64 parts of kaolin, and 150 parts of purified water.

8. The method for preparing the Chinese medicine plaster gel according to claims 6 to 7, characterized in that: The following steps are involved: S1: crush the above raw materials to obtain medicinal powder; S2: weigh tartaric acid, add purified water and stir until completely dissolved, as the water phase; S3: weigh aluminum glycolate, NP-700 and kaolin in an evaporating dish, mix, add glycerol and volatile oil sample and stir evenly, as the oil phase; S4: add the water phase and medicinal powder to the oil phase, and evaporating at 60 r min -1 S5: placing the gel on a non-woven fabric and covering it with an embossed film for coating, and leaving it at room temperature for forming.