Bacteriostatic and anti-inflammatory functional dressing as well as preparation method and application thereof
By using specific proportions of glycerol, sodium alginate, carbomer, β-glucan, disodium lauryl sulfosuccinate, cocamidopropyl betaine and water in the dressing, the problems of insufficient water absorption and lack of moisturizing function in the dressing are solved, and efficient wound healing and reducing inflammatory response are achieved.
Patent Information
- Application Number
- CN202510067195.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-01-16
- Publication Date
- 2025-05-27
AI Technical Summary
During use, existing dressings have problems such as limited water absorption, lack of moisturizing function, insufficient breathability or need to be replaced frequently, which leads to inconvenient use and may affect wound healing.
A functional dressing including glycerol, sodium alginate, carbomer, beta-glucan, disodium lauryl sulfosuccinate, cocamidopropyl betaine and water is used to enhance the moisturizing, anti-inflammatory and immune-regulating effects of the dressing through specific proportions.
This functional dressing has good moisturizing and anti-inflammatory effects, can form a protective layer, reduce inflammatory response, accelerate tissue repair, and promote wound healing.
Smart Images
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Abstract
Description
Technical Field
[0001] The invention belongs to the technical field of dressing preparation, and specifically relates to a functional dressing for inhibiting bacteria and inflammation, and a preparation method and application thereof. Background Art
[0002] When a wound forms on human or animal skin, it often goes through major processes such as hemostasis, inflammation, proliferation and remodeling. Among them, wound inflammation is an immune response of the body to the injured part, usually to resist infection and promote healing. However, if inflammation is not treated promptly and appropriately, it may lead to more serious complications.
[0003] In the prior art, common types of dressings include traditional gauze dressings, semipermeable membrane dressings, hydrocolloid dressings, and foam dressings, but the above materials have limited water absorption, lack of moisturizing function, or insufficient air permeability, or need to be frequently replaced, so they often bring inconvenience to users during use, and in severe cases, even make wounds difficult to heal. Therefore, how to provide a dressing that is easy to use and has good effects is a problem that needs to be solved urgently in this field. Summary of the invention
[0004] The purpose of the present invention is to provide a functional dressing with antibacterial and anti-inflammatory properties, and a preparation method and application thereof. The functional dressing is easy to use, has good antibacterial and anti-inflammatory effects, and is beneficial to promoting wound healing.
[0005] The invention provides a functional dressing for inhibiting bacteria and reducing inflammation. The functional dressing comprises glycerol, sodium alginate, carbomer, beta-glucan, disodium lauryl sulfosuccinate, cocamidopropyl betaine and water.
[0006] Preferably, the functional dressing comprises, by mass percentage, 15%-25% glycerol, 0.15%-0.2% sodium alginate, 0.15%-0.3% carbomer, 0.2%-0.3% β-glucan, 25%-35% disodium lauryl sulfosuccinate, 4%-8% cocamidopropyl betaine and the balance water.
[0007] Preferably, the functional dressing comprises, by mass percentage, 20% glycerol, 0.15% sodium alginate, 0.15% carbomer, 0.2% β-glucan, 30% disodium lauryl sulfosuccinate, 6% cocamidopropyl betaine and the balance water.
[0008] Preferably, the carbomer includes: carbomer 980NF.
[0009] The present invention provides a method for preparing the functional dressing described in the above technical solution, comprising the following steps:
[0010] Mixing sodium alginate, carbomer and β-glucan with glycerol to obtain mixture A;
[0011] Under heating conditions, the mixture A is completely dissolved in water, and then disodium lauryl sulfosuccinate and cocamidopropyl betaine are added to the water in sequence to obtain a mixture B;
[0012] The mixture B is cooled to obtain an intermediate product;
[0013] The intermediate product is sterilized to obtain a functional dressing.
[0014] Preferably, the heating temperature is 75-85°C.
[0015] Preferably, the cooling temperature is 30-40°C.
[0016] Preferably, the sterilization comprises: irradiating the intermediate product with 25 kGy for sterilization.
[0017] The present invention provides the use of the functional dressing described in the above technical solution in the preparation of products for inhibiting bacteria and inflammation and / or promoting wound healing.
[0018] Preferably, the antibacterial and anti-inflammatory effects include: inhibiting inflammation caused by superficial wounds and the surrounding skin.
[0019] Beneficial effects:
[0020] The present invention provides a functional dressing for inhibiting bacteria and reducing inflammation, and the functional dressing comprises: glycerol, sodium alginate, carbomer, β-glucan, disodium lauryl sulfosuccinate, cocamidopropyl betaine and water. The present invention is conducive to improving the moisturizing and nourishing effect of the functional dressing by adding glycerol and carbomer; in addition, sodium alginate can form a soft and elastic gel film, so the functional dressing can provide a physical barrier to protect the wound from external pollution and friction damage; in addition, since β-glucan, disodium lauryl sulfosuccinate and cocamidopropyl betaine have anti-inflammatory and immunomodulatory effects, the functional dressing can greatly promote wound healing, reduce inflammatory reactions, and accelerate tissue repair.
[0021] Based on the above advantages, the present invention also provides a method for preparing the functional dressing described in the above technical solution Su, and its use in preparing products for inhibiting bacteria and inflammation and / or promoting wound healing. The above functional dressing forms a protective layer on the wound surface, acts as a physical barrier, and can be used for cleaning and caring for superficial wounds and surrounding skin caused by small wounds, abrasions, cuts, lasers, photorejuvenation, acid rejuvenation, micro plastic surgery or hair transplantation. DETAILED DESCRIPTION
[0022] To further illustrate the present invention, the solutions provided by the present invention will be described in detail below in conjunction with embodiments, but they should not be construed as limiting the protection scope of the present invention.
[0023] Embodiment 1
[0024] A preparation method of a bacteriostatic and anti-inflammatory functional dressing, the steps are as follows:
[0025] (1) By mass percentage, the functional dressing includes: 15% glycerol, 0.15% sodium alginate, 0.15% carbomer 980NF, 0.2% β-glucan, 25% disodium lauryl sulfosuccinate, 4% cocamidopropyl betaine and the balance of pure water;
[0026] (2) Preparation method: Disperse sodium alginate, carbomer, and β-glucan with glycerol, and visually check for no obvious large particles or lumps to obtain standby material 1; Weigh pure water and add it to a beaker, and add standby material 1, then heat it in a water bath to 80°C, keep stirring for about 20 minutes until completely dissolved; Then add disodium lauryl sulfosuccinate to the beaker, keep stirring for 20 minutes, visually check for no insoluble large particles, add cocamidopropyl betaine, stir for 5 minutes, and slowly cool down to 35°C and stir to form a white to slightly yellow cream-like substance, which is the prepared intermediate product. After filling the intermediate product, perform 25 kGy radiation sterilization.
[0027] Embodiment 2
[0028] A preparation method of a bacteriostatic and anti-inflammatory functional dressing, the steps are as follows:
[0029] (1) By mass percentage, the functional dressing includes: 20% glycerol, 0.15% sodium alginate, 0.15% carbomer 980NF, 0.2% β-glucan, 30% disodium lauryl sulfosuccinate, 6% cocamidopropyl betaine and the balance of pure water;
[0030] (2) Preparation method: Disperse sodium alginate, carbomer, and β-glucan with glycerol, and visually check for no obvious large particles or lumps to obtain standby material 1; Weigh pure water and add it to a beaker, and add standby material 1, then heat it in a water bath to 80°C, keep stirring for about 20 minutes until completely dissolved; Then add disodium lauryl sulfosuccinate to the beaker, keep stirring for 20 minutes, visually check for no insoluble large particles, add cocamidopropyl betaine, stir for 5 minutes, and slowly cool down to 35°C and stir to form a white to slightly yellow cream-like substance, which is the prepared intermediate product. After filling the intermediate product, perform 25 kGy radiation sterilization.
[0031] Embodiment 3
[0032] A preparation method of a functional dressing with antibacterial and anti-inflammatory effects, the steps are as follows:
[0033] (1) By mass percentage, the functional dressing includes: 25% glycerol, 0.15% sodium alginate, 0.15% carbomer 980NF, 0.2% β-glucan, 25% disodium lauryl sulfosuccinate, 8% cocamidopropyl betaine and the balance purified water;
[0034] (2) Preparation method: Take sodium alginate, carbomer and β-glucan and disperse them with glycerol until there are no obvious large particles or lumps visually to obtain standby material 1; Weigh purified water and add it to a beaker, then add standby material 1, and then heat it in a water bath to 80 °C, keep stirring for about 20 min until completely dissolved; Then add disodium lauryl sulfosuccinate to the beaker, keep stirring for 20 min, visually check for no insoluble large particles, add cocamidopropyl betaine, stir for 5 min, and slowly cool down to 35 °C and stir to form a white to slightly yellow cream-like substance to obtain the formulated intermediate product. After filling the intermediate product, perform radiation sterilization at 25 kGy.
[0035] The appearance of the functional dressings prepared in Examples 1-3 was evaluated respectively, and each sample was centrifuged at 3000 r / min for 30 min. The results are shown in Table 1.
[0036] Table 1 Appearance description of the functional dressing in different treatments
[0037]
[0038]
[0039] Respectively take 0.2 g of the functional dressings prepared in Examples 1-3, add 20 g of boiled and cooled purified water, heat to dissolve and keep stirring until uniform, cool to room temperature, and perform detection according to the "Standard Operating Procedure for pH Value Detection". Each sample is repeated in parallel 2 times. The results are shown in Table 2.
[0040] Table 2 pH values of the functional dressing in different treatments
[0041] Treatment pH-1 pH-2 Mean Example 1 (R1) 6.36 6.42 6.39 Example 2 (R2) 6.48 6.46 6.47 Example 3 (R3) 6.43 6.49 6.46
[0042] As can be seen from Table 2, for the functional dressing provided by the present invention, its pH value is between 4.0 and 8.0, meeting the pH value requirements of the product.
[0043] Respectively take the functional dressings prepared in Examples 1-3 to measure the viscosity. Each sample is repeated in parallel 2 times. Using a medical paste dressing (Jilin Medical Device Approval No. 20222140465) as a reference substance, the results are shown in Table 3.
[0044] Table 3 Viscosity of the functional dressing in different treatments (unit: )
[0045] Treatment Replicate 1 Replicate 2 Mean Example 1 (R1) 4423 5217 4820 Example 2 (R2) 14109 14111 14110 Example 3 (R3) 43252 44320 43786 Reference substance 13207 13246 13226
[0046] As can be seen from Table 3, the functional dressing provided by the present invention meets the detection standard of the third method in General Rule 0633 of the Fourth Part of the Chinese Pharmacopoeia (2020 Edition), and the viscosity is not less than 1000 。
[0047] The functional dressings prepared in Examples 1-3 were respectively taken to measure the skin feel comfort and moisturizing property. Five different volunteers were used to test each product, and the results are shown in Table 4.
[0048] Table 4 Skin feel comfort and moisturizing property of the functional dressing in different treatments
[0049]
[0050]
[0051] Note: The specific scoring criteria in Table 4 are as follows:
[0052] Highest score: 5 points; easy to spread, good moisturizing, easy to rinse, no discomfort (such as stinging, dryness, flushing, etc.), high skin moisturizing degree after absorption;
[0053] Passing score: 3 points; slightly difficult to spread, medium moisturizing, relatively easy to rinse, no discomfort (such as stinging, dryness, flushing, etc.), medium skin moisturizing degree after absorption;
[0054] Lowest score: 1 point; difficult to spread, poor moisturizing, relatively easy to rinse, with phenomena such as stinging, dryness, flushing, etc.
[0055] Combined with Table 4, it can be seen that the skin feel comfort and moisturizing property of the functional dressings provided in Examples 1-3 of the present invention are not very different, but the functional dressing prepared in Example 2 has the strongest moisturizing and moisturizing feeling.
[0056] In summary, the appearance and pH value of the functional dressing provided by the present invention meet the requirements; the viscosity of the functional dressing prepared in Example 2 is closest to that of the reference substance; after centrifugation, no layering phenomenon occurs in the three samples, that is, the stabilities of the three products are good; combined with the skin feel comfort and moisturizing property of the samples, it can be found that the functional dressing prepared in Example 2 has the strongest comprehensive performance.
[0057] Comparative Example 1
[0058] A preparation method of an antibacterial and anti-inflammatory functional dressing, the steps are as follows:
[0059] (1) By mass percentage, the functional dressing comprises: 30% glycerol, 0.15% sodium alginate, 0.15% carbomer 980NF, 0.2% β-glucan, 40% disodium lauryl sulfosuccinate, 6% cocamidopropyl betaine and the balance purified water;
[0060] (2) Preparation method: Disperse sodium alginate, carbomer and β-glucan with glycerol until there are no obvious large particles or lumps visually to obtain standby material 1; Weigh purified water and add it into a beaker, then add standby material 1, and then heat it in a water bath to 80 °C, keep stirring for about 20 min until completely dissolved; Then add disodium lauryl sulfosuccinate into the beaker, keep stirring for 20 min, visually check that there are no insoluble large particles, add cocamidopropyl betaine, stir for 5 min, and slowly cool down to 35 °C and stir to form a white to slightly yellow cream-like substance to obtain the formulated intermediate product. After filling the intermediate product, carry out 25 kGy radiation sterilization.
[0061] Comparative Example 2
[0062] A preparation method of an antibacterial and anti-inflammatory functional dressing, the steps are as follows:
[0063] (1) By mass percentage, the functional dressing comprises: 10% glycerol, 0.15% sodium alginate, 0.15% carbomer 980NF, 0.2% β-glucan, 40% disodium lauryl sulfosuccinate and the balance purified water;
[0064] (2) Preparation method: Disperse sodium alginate, carbomer and β-glucan with glycerol until there are no obvious large particles or lumps visually to obtain standby material 1; Weigh purified water and add it into a beaker, then add standby material 1, and then heat it in a water bath to 80 °C, keep stirring for about 20 min until completely dissolved; Then add disodium lauryl sulfosuccinate into the beaker, keep stirring for 20 min, visually check that there are no insoluble large particles, slowly cool down to 35 °C and stir to form a white to slightly yellow cream-like substance to obtain the formulated intermediate product. After filling the intermediate product, carry out 25 kGy radiation sterilization.
[0065] Comparative Example 3
[0066] Commercially available dressing.
[0067] Comparative Example 4
[0068] A preparation method of an antibacterial and anti-inflammatory functional dressing, the steps are as follows:
[0069] (1) By mass percentage, the functional dressing comprises: 20% glycerol, 0.15% sodium alginate, 0.15% carbomer 980NF, 0.2% β-glucan, 30% sodium lauryl ether sulfate, 6% cocamidopropyl betaine, and the balance purified water;
[0070] (2) Preparation method: Disperse sodium alginate, carbomer, and β-glucan with glycerol until there are no obvious large particles or lumps visible to the naked eye to obtain reserve material 1; Weigh purified water and add it to a beaker, then add reserve material 1, and then heat it in a water bath to 80°C and keep stirring for about 20 minutes until completely dissolved; Then add sodium lauryl ether sulfate to the beaker, keep stirring for 20 minutes, and visually check for no insoluble large particles. Add cocamidopropyl betaine and stir for 5 minutes, and slowly cool down to 35°C while stirring to form a white to slightly yellow cream-like substance, which is the prepared intermediate product. After filling the intermediate product into containers, perform 25 kGy radiation sterilization.
[0071] Comparative Example 5
[0072] A preparation method of an antibacterial and anti-inflammatory functional dressing, the steps are as follows:
[0073] (1) By mass percentage, the functional dressing comprises: 20% propylene glycol, 0.15% sodium alginate, 0.15% carbomer 980NF, 0.2% β-glucan, 30% disodium laureth sulfosuccinate, 6% cocamidopropyl hydroxyethyl sulfonate, and the balance purified water;
[0074] (2) Preparation method: Disperse sodium alginate, carbomer, and β-glucan with propylene glycol until there are no obvious large particles or lumps visible to the naked eye to obtain reserve material 1; Weigh purified water and add it to a beaker, then add reserve material 1, and then heat it in a water bath to 80°C and keep stirring for about 20 minutes until completely dissolved; Then add disodium laureth sulfosuccinate to the beaker, keep stirring for 20 minutes, and visually check for no insoluble large particles. Add cocamidopropyl hydroxyethyl sulfonate and stir for 5 minutes, and slowly cool down to 35°C while stirring to form a white to slightly yellow cream-like substance, which is the prepared intermediate product. After filling the intermediate product into containers, perform 25 kGy radiation sterilization.
[0075] Application Example 1
[0076] Take 50 healthy rats with a body weight of 155 - 165 g and raise them in the same environment; Then randomly divide the rats into 5 groups, with 10 rats in each group. Anesthetize the rats, remove the back hair, and create a circular wound with a diameter of 1 cm on the back full skin;
[0077] Taking the functional dressings prepared in Example 2 and the dressings in Comparative Examples 1-5 as experimental objects, and using the treatment of applying clear water as the blank control, apply the above dressings on the wounds on the back of mice twice a day until the wound surface is completely covered; calculate the wound healing degree of the rats every two days, and count 4 times in total. The results are shown in Table 5.
[0078] Among them, the wound healing degree = (initial wound area - wound area on the Nth day) / initial wound area × 100%.
[0079] Table 5 Wound healing degree in different treatments (unit: %)
[0080] Treatment Day 1 Day 3 Day 5 Day 7 Example 2 0 30.5 51.3 78.5 Comparative Example 1 0 30.1 49.8 70.2 Comparative Example 2 0 29.7 47.6 69.8 Comparative Example 3 0 29.0 49.5 73.5 Comparative Example 4 0 24.7 39.8 65.4 Comparative Example 5 0 20.1 37.6 63.7 Blank control 0 10.8 30.1 48.6
[0081] Combined with the data in Table 5, it can be seen that compared with Comparative Examples 1-5 and the blank control, the functional dressing prepared in this application has the best effect on promoting wound healing, and the highest wound healing degree can reach 78.5%; when used for 5 days, the wound healing rate has reached more than half, and the healing speed is relatively fast; while changing some raw material components or the addition amount in the functional dressing significantly reduces the wound healing speed and is not conducive to wound healing.
[0082] Thus, by compounding glycerol, sodium alginate, carbomer, β-glucan, disodium lauryl sulfosuccinate, cocamidopropyl betaine and water in a specific ratio, the present invention has a synergistic effect, improves the function of the dressing, greatly promotes wound healing, reduces inflammatory reactions, and accelerates tissue repair.
[0083] Although the above embodiments have described the present invention in detail, they are only a part of the embodiments of the present invention, not all embodiments. People can also obtain other embodiments according to these embodiments without creative efforts, and these embodiments all fall within the protection scope of the present invention.
Claims
1. A functional dressing for inhibiting bacteria and reducing inflammation, characterized in that: The functional dressing comprises glycerin, sodium alginate, carbomer, beta-glucan, disodium lauryl sulfosuccinate, cocamidopropyl betaine and water.
2. The functional dressing according to claim 1, characterized in that: Calculated by mass percentage, the functional dressing includes: 15%-25% glycerol, 0.15%-0.2% sodium alginate, 0.15%-0.3% carbomer, 0.2%-0.3% beta-glucan, 25%-35% disodium lauryl sulfosuccinate, 4%-8% cocamidopropyl betaine and the balance water.
3. The functional dressing according to claim 2, characterized in that: Calculated by mass percentage, the functional dressing includes: 20% glycerol, 0.15% sodium alginate, 0.15% carbomer, 0.2% beta-glucan, 30% disodium lauryl sulfosuccinate, 6% cocamidopropyl betaine and the balance water.
4. The functional dressing according to any one of claims 1 to 3, characterized in that: The carbomer includes: carbomer 980NF.
5. The method for preparing the functional dressing according to any one of claims 1 to 4, characterized in that: The steps include: Mixing sodium alginate, carbomer and β-glucan with glycerol to obtain mixture A; Under heating conditions, the mixture A is completely dissolved in water, and then disodium lauryl sulfosuccinate and cocamidopropyl betaine are added to the water in sequence to obtain a mixture B; The mixture B is cooled to obtain an intermediate product; The intermediate product is sterilized to obtain a functional dressing.
6. The preparation method according to claim 5, characterized in that: The heating temperature is 75-85°C.
7. The preparation method according to claim 5, characterized in that: The cooling temperature is 30-40°C.
8. The preparation method according to claim 5, characterized in that: The sterilization comprises: irradiating and sterilizing the intermediate product with 25 kGy.
9. Use of the functional dressing according to any one of claims 1 to 4 in the preparation of products for inhibiting bacteria, reducing inflammation and / or promoting wound healing.
10. The use according to claim 9, characterized in that: The antibacterial and anti-inflammatory treatment includes: inhibiting inflammation caused by superficial wounds and the surrounding skin.