Computer simulation method and device for determining electrode patch position

Abstract

The invention provides a computer simulation method and device for determining the position of an electrode patch. The method comprises the following steps: acquiring a mouse simulation model, wherein the mouse simulation model is obtained by performing three-dimensional reconstruction on a mouse with a brain tumor; simulation electrode patch pairs are sequentially arranged at multiple pairs of candidate positions in the head area of the mouse simulation model, and simulation alternating electric signals are applied to the simulation electrode patch pairs; for each pair of candidate positions in the multiple pairs of candidate positions, recording an electric field intensity value of a simulation electric field established between the simulation electrode patch pairs by the simulation alternating electric signals when the simulation electrode patch pairs are arranged at the candidate positions; selecting a pair of candidate positions with the maximum electric field intensity value from the plurality of pairs of candidate positions as target electrode patch positions; and determining an electrode patch corresponding to the position of the target electrode patch according to the position of the target electrode patch.

Description

Technical Field

[0001] The present disclosure relates to computer simulation technologies, and particularly to a computer simulation method, a computer simulation device, an electronic device, a computer-readable storage medium, and a computer program product for determining the positions of electrode patches. Background Art

[0002] Tumor Treating Fields (TTF) is a physical therapy based on bioelectricity. This therapy uses low-intensity, medium-frequency alternating electric fields to affect the aggregation of tubulin, prevent the formation of the spindle, inhibit the mitotic process, and induce apoptosis of cancer cells, while reducing damage to healthy cells, so as to effectively avoid the impact on the quality of life of patients caused by treatment side effects.

[0003] In order to achieve better treatment effects, it is usually necessary to attach the electrode patches of the treatment instrument to specific positions that can form a strong tumor treatment electric field for the tissue where the tumor lesion of the experimental subject is located. Therefore, in the process of basic research, it is particularly important to obtain a large amount of animal experiment data on head tumor treatment to determine the above specific positions.

[0004] In the prior art, usually, paired electrode patches are directly attached to the tissue position where the tumor lesion of the experimental animal is located, so as to obtain the electric field intensity of the tumor treatment electric field between the electrode patches as research data. However, this method requires a large amount of manpower and material resources, and is easily interfered by irrelevant factors such as the movement of the experimental animal during the process of obtaining data. The efficiency of obtaining data is low and the quality of the obtained data is not high, and the applicable range is limited. Summary of the Invention

[0005] It would be advantageous to provide a mechanism that alleviates, mitigates, or even eliminates one or more of the above problems.

[0006] According to one aspect of the present disclosure, there is provided a computer simulation method for determining the positions of electrode patches, including: obtaining a mouse simulation model, which is obtained by three-dimensionally reconstructing a mouse with a brain tumor; sequentially setting simulation electrode patch pairs at multiple pairs of candidate positions within the head region of the mouse simulation model, and applying a simulation alternating electric signal to the simulation electrode patch pairs; for each pair of candidate positions among the multiple pairs of candidate positions, recording the electric field intensity value of the simulation electric field established between the simulation electrode patch pairs when the simulation electrode patch pairs are set at this pair of candidate positions; selecting a pair of candidate positions with the maximum electric field intensity value from the multiple pairs of candidate positions as the target electrode patch positions; and determining the electrode patches corresponding to the target electrode patch positions according to the target electrode patch positions.

[0007] According to another aspect of the present disclosure, there is also provided a computer simulation device for determining the position of an electrode patch, including: a first module configured to obtain a mouse simulation model, which is obtained by three-dimensionally reconstructing a mouse with a brain tumor; a second module configured to sequentially set simulation electrode patch pairs at multiple pairs of candidate positions within the head region of the mouse simulation model, and a simulation alternating current signal is applied to the simulation electrode patch pairs; a third module configured to, for each pair of candidate positions among the multiple pairs of candidate positions, record the electric field strength value of the simulation electric field established between the simulation electrode patch pairs when the simulation electrode patch pairs are set at this pair of candidate positions; a fourth module configured to select, as the target electrode patch position, a pair of candidate positions with the maximum electric field strength value from the multiple pairs of candidate positions and determine an electrode patch corresponding to the target electrode patch position according to the target electrode patch position.

[0008] According to another aspect of the present disclosure, there is also provided an electronic device, including: at least one processor; and a memory communicatively connected to the at least one processor; wherein the memory stores instructions executable by the at least one processor, and when the instructions are executed by the at least one processor, the at least one processor is enabled to execute the method as described above.

[0009] According to another aspect of the present disclosure, there is provided a non-transitory computer-readable storage medium storing computer instructions, wherein the computer instructions are used to cause a computer to execute the method as described above.

[0010] According to another aspect of the present disclosure, there is provided a computer program product, including a computer program, wherein when the computer program is executed by a processor, the method as described above is implemented.

[0011] According to the embodiments described below, these and other aspects of the present disclosure will be clear and will be elucidated with reference to the embodiments described below. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] In the following description of exemplary embodiments with reference to the accompanying drawings, more details, features and advantages of the present disclosure are disclosed. In the drawings:

[0013] Figure 1 is a flowchart showing a computer simulation method for determining the position of an electrode patch according to an exemplary embodiment;

[0014] Figure 2 is a schematic diagram showing the setting positions of simulation electrode patches within the head region of a mouse simulation model according to an exemplary embodiment;

[0015] Figure 3 is a partial flowchart showing a computer simulation method for determining the position of an electrode patch according to an exemplary embodiment;

[0016] Figure 4 is a schematic block diagram showing a computer simulation device for determining the position of an electrode patch according to an exemplary embodiment;

[0017] Figure 5 is a block diagram showing the structure of an exemplary computing device that can be applied to an exemplary embodiment;

[0018] Figure 6 is a schematic structural diagram showing a tumor treating electric field device according to an example;

[0019] Figure 7A and Figure 7B are perspective views showing a transfer board for animal experiments of a tumor treating electric field device according to an example from different perspectives;

[0020] Figure 8 is a schematic structural diagram of an animal head electrode of a tumor treating electric field device according to an example;

[0021] Figure 9 is a schematic structural diagram of an electrode functional component and a partial cable component of a tumor treating electric field device according to an example;

[0022] Figure 10 is a schematic diagram of the surface of a dielectric element facing one side of a conductive core of a tumor treating electric field device according to an example;

[0023] Figure 11 is a schematic diagram of the dimensions of a flexible printed circuit board of a tumor treating electric field device according to an example;

[0024] Figure 12 is a schematic structural diagram of an electrode functional component, a back lining, an adhesive, and a partial cable component of a tumor treating electric field device according to an example. Detailed implementation manners

[0025] In the present disclosure, unless otherwise specified, the use of terms such as "first" and "second" to describe various elements does not intend to limit the positional relationship, timing relationship, or importance relationship of these elements. Such terms are only used to distinguish one element from another. In some examples, the first element and the second element may refer to the same instance of the element, and in certain cases, based on the context description, they may also refer to different instances.

[0026] In the description of the various examples in this disclosure, the terms used are for the purpose of describing specific examples only and are not intended to be limiting. Unless the context clearly indicates otherwise, if the number of elements is not specifically defined, the element can be one or more. As used herein, the term "plurality" means two or more, and the term "based on" should be interpreted as "at least partially based on". In addition, the terms "and / or" and "at least one of..." cover any one of the listed items and all possible combinations thereof.

[0027] For tumor electrotherapy, the greater the electric field intensity that can be provided for the target tumor, the better the effect of the electric field interfering with the mitosis of tumor cells. In specific implementation, the magnitude of the provided electric field intensity depends to a large extent on the setting position of the pair of electrode patches used to apply the electric field. For example, whether the electrode patches can accurately cover the tissue area where the lesion is located, or the relative position setting method between the two electrode patches, etc.

[0028] The corresponding electric field intensity values can be compared by setting the electrode patches at different body parts of the animal experimental subject to determine the position of the electrode patch with the highest electric field intensity value. However, due to the movement of the animal experimental subject itself and the influence of surrounding environmental factors, the accuracy of the measured electric field intensity value is not high. Moreover, this method requires moving the electrode patches multiple times and performing measurements, which will consume a large amount of manpower and material resources.

[0029] Based on this, the present disclosure proposes a computer simulation method for determining the position of electrode patches. By performing three-dimensional reconstruction on a mouse with a brain tumor, a corresponding mouse simulation model is obtained, and simulation electrode patch pairs applied with simulated alternating current signals are sequentially set at multiple preset positions in the head region of the mouse simulation model, so as to be able to obtain multiple electric field intensity values corresponding to different preset positions as research data, and to determine the target electrode patch setting position that can provide the most effective treatment according to the magnitude of the electric field intensity value and determine the electrode sheet corresponding to the target electrode patch position according to the target electrode patch position. Thus, real objective interference factors are excluded, and accurate electric field intensity measurement data is provided. In addition, through the computer simulation method, a large number of repeated experiments can be carried out in a short time, which can effectively improve efficiency and save resources.

[0030] The computer simulation method for determining the position of electrode patches according to the present disclosure will be further described below with reference to the accompanying drawings.

[0031] Figure 1 is a flowchart of a computer simulation method for determining the position of electrode patches according to an exemplary embodiment of the present disclosure.

[0032] As Figure 1 shown, the computer simulation method for determining the position of electrode patches includes:

[0033] Step S101: Obtain a mouse simulation model, which is obtained by three-dimensional reconstruction of a mouse with a brain tumor.

[0034] Step S102: Sequentially set simulation electrode patch pairs at multiple pairs of candidate positions within the head region of the mouse simulation model, and apply a simulation alternating current signal to the simulation electrode patch pairs.

[0035] Step S103: For each pair of candidate positions among the multiple pairs of candidate positions, record the electric field intensity value of the simulation electric field established between the simulation electrode patch pairs when the simulation electrode patch pairs are set at this pair of candidate positions.

[0036] Step S104: Select a pair of candidate positions with the maximum electric field intensity value from the multiple pairs of candidate positions as the target electrode patch position.

[0037] Step S105: Determine the electrode patch corresponding to the target electrode patch position according to the target electrode patch position.

[0038] In the above method, since the mouse simulation model constructed by three-dimensional reconstruction can be reused, the accurate target electrode patch position can be determined according to factors such as the size, shape, and brain tumor location of the mouse simulation model. In addition, since no actual animal experiments are required, the process can be simplified and the efficiency can be improved.

[0039] According to some embodiments, each pair of candidate positions includes a first position and a second position, and the first position and the second position are spaced apart from each other. Specifically, by setting the first position and the second position at intervals, it is possible to avoid a large amount of alternating current concentrating on a certain part of the mouse simulation model due to overlapping electrode patch settings, changing the corresponding electric field distribution, and thus affecting the magnitude of the finally obtained electric field intensity value. Moreover, overlapping of electrode patches may also cause the temperature at the overlapping part to be too high, resulting in the situation of burning the mouse in reality and reducing the effectiveness of the simulation test results.

[0040] Figure 2 It is a schematic diagram showing the setting positions of the simulation electrode patches in the head region of the mouse simulation model according to an exemplary embodiment. In Figure 2 In the illustrated example, the first position is located between the left ear and the left eye of the mouse simulation model, and the second position is located between the right ear and the right eye of the mouse simulation model. The electrode patches 111 and 112 are respectively attached to the first position and the second position.

[0041] This example targets a mouse simulation model with a brain tumor (e.g., glioma). Therefore, by setting the first position and the second position between the ears and eyes on the left and right sides of the mouse's head, respectively, the electrode patches can be located on both sides of the brain tumor. At this time, the electric field generated is likely to act on the brain tumor location of the mouse simulation model, effectively reducing the number of candidate locations that need to be tested and improving the efficiency of the simulation test.

[0042] Moreover, in actual implementation, this setting method can also improve the comfort and feeding problems of the mouse when the electrode patch is applied to the mouse's head, further improving the effectiveness of the final target electrode patch position.

[0043] According to some embodiments, the simulated alternating electrical signal includes a first alternating electrical signal and a second alternating electrical signal with opposite polarities, and the first alternating electrical signal and the second alternating electrical signal are respectively applied to two simulated electrode patches in the simulated electrode patch pair.

[0044] Specifically, by setting two simulated alternating electric signals with opposite polarities to be applied to the simulated electrode patches, an electric field can be formed between a pair of candidate positions.

[0045] In one example, the first alternating electrical signal and the second alternating electrical signal satisfy at least one of the following conditions: a frequency between 150 kHz and 300 kHz, an intensity greater than or equal to 20 Vpp, and a duration greater than or equal to 72 hours.

[0046] The above conditions are the setting ranges suitable for mouse animal experiments summarized through a large number of experiments. Based on this, the amount of calculation for simulation testing can be further reduced, thereby saving resources and improving efficiency.

[0047] Figure 3 is a partial flow chart illustrating a computer simulation method for determining electrode patch positions according to an exemplary embodiment. Figure 3 As shown, according to some embodiments, before step S101, the above-mentioned computer simulation method also includes: step S1001, using computer tomography technology to image mice with brain tumors to obtain three-dimensional imaging information; step S1002, constructing a mouse simulation model based on the three-dimensional imaging information.

[0048] In one example, a simulation electrode patch can be constructed by COMSOL Multiphysics (a multi-physics simulation software), and a simulated alternating electric signal applied thereto can be set. At the same time, in order to adapt to COMSOL Multiphysics, a mouse can be three-dimensionally imaged based on computed tomography techniques (such as CT, OCT, etc.), and the obtained three-dimensional imaging information can be imported into COMSOL Multiphysics to construct a corresponding mouse simulation model, so as to implement the computer simulation method for determining the position of the electrode patch of the present disclosure.

[0049] It should be noted that the above COMSOL Multiphysics simulation software is only for illustrative purposes and is not limited thereto. In the specific implementation process, other adaptable means and simulation software can also be used to perform three-dimensional imaging and corresponding electric field simulation tests on mice with brain tumors.

[0050] According to another aspect of the present disclosure, as Figure 4 shown, there is also provided a computer simulation device 100 for determining the position of an electrode patch, including: a first module 101 for obtaining a mouse simulation model, which is obtained by three-dimensionally reconstructing a mouse with a brain tumor; a second module 102 for sequentially setting simulation electrode patch pairs at multiple pairs of candidate positions within the head region of the mouse simulation model, and a simulated alternating electric signal is applied to the simulation electrode patch pairs; a third module 103 for, for each pair of candidate positions among the multiple pairs of candidate positions, recording the electric field strength value of the simulated electric field established between the simulation electrode patch pairs when the simulation electrode patch pairs are set at the pair of candidate positions; a fourth module 104 for selecting, as the target electrode patch position, a pair of candidate positions with the largest electric field strength value from the multiple pairs of candidate positions, and determining an electrode patch corresponding to the target electrode patch position according to the target electrode patch position.

[0051] According to some embodiments, the computer simulation device 100 may further include: a fifth module 105 for imaging a mouse with a brain tumor using computed tomography techniques to obtain three-dimensional imaging information; and a sixth module 106 for constructing a mouse simulation model based on the three-dimensional imaging information.

[0052] It should be understood that Figure 4 each module of the device 100 shown in Figure 1 may correspond to each step in the method described with reference to

[0053] Although specific functions have been discussed above with reference to specific modules, it should be noted that the functions of the various modules discussed herein can be divided into multiple modules, and / or at least some of the functions of multiple modules can be combined into a single module. The actions performed by the specific modules discussed herein include the specific module itself performing the action, or alternatively the specific module invoking or otherwise accessing another component or module that performs the action (or performs the action in combination with the specific module). Thus, a specific module that performs an action can include the specific module itself that performs the action and / or another module that the specific module invokes or otherwise accesses and that performs the action.

[0054] It should also be understood that the various techniques herein can be described in the general context of software-hardware elements or program modules. The various modules described above Figure 4 can be implemented in hardware or in hardware in combination with software and / or firmware. For example, these modules can be implemented as computer program code / instructions that are configured to execute in one or more processors and stored in a computer-readable storage medium. Alternatively, these modules can be implemented as hardware logic / circuits. For example, in some embodiments, one or more of the first module 101, the second module 102, the third module 103, the fourth module 104, the fifth module 105, and the sixth module 106 can be implemented together in a system on chip (SoC). The SoC can include an integrated circuit chip (which includes one or more components such as a processor (e.g., a central processing unit (CPU), a microcontroller, a microprocessor, a digital signal processor (DSP), etc.), a memory, one or more communication interfaces, and / or other circuits), and can optionally execute the received program code and / or include embedded firmware to perform functions.

[0055] According to another aspect of the present disclosure, there is also provided an electronic device, including: at least one processor; and a memory communicatively connected to the at least one processor; wherein the memory stores instructions executable by the at least one processor, and the instructions are executed by the at least one processor to enable the at least one processor to execute the method described in the present disclosure.

[0056] According to another aspect of the present disclosure, there is provided a non-transitory computer-readable storage medium storing computer instructions, wherein the computer instructions are used to cause a computer to execute the method described in the present disclosure.

[0057] According to another aspect of the present disclosure, there is provided a computer program product including a computer program, wherein the computer program, when executed by a processor, implements the method described in the present disclosure above.

[0058] Reference Figure 5 Figure 5 is now described a computing device 1000, which is an example of a hardware device to which aspects of the present disclosure can be applied. The computing device 1000 can be any machine configured to perform processing and / or computing, and can be, but is not limited to, a workstation, a server, a desktop computer, a laptop computer, a tablet computer, a personal digital assistant, a smart phone, an in-vehicle computer, or any combination thereof. The above-described simulation device for determining the positions of electrode patches can be implemented in whole or at least in part by the computing device 1000 or a similar device or system.

[0059] The computing device 1000 can include (possibly via one or more interfaces) elements connected to or communicating with a bus 1002. For example, the computing device 1000 can include a bus 1002, one or more processors 1004, one or more input devices 1006, and one or more output devices 1008. The one or more processors 1004 can be any type of processor, and can include, but is not limited to, one or more general-purpose processors and / or one or more dedicated processors (such as special processing chips). The input device 1006 can be any type of device capable of inputting information to the computing device 1000, and can include, but is not limited to, a mouse, a keyboard, a touch screen, a microphone, and / or a remote control. The output device 1008 can be any type of device capable of presenting information, and can include, but is not limited to, a display, a speaker, a video / audio output terminal, a vibrator, and / or a printer. The computing device 1000 can also include a non-transitory storage device 1010 or be connected to a non-transitory storage device 1010. The non-transitory storage device can be any storage device that is non-transitory and can implement data storage, and can include, but is not limited to, a disk drive, an optical storage device, a solid-state memory, a floppy disk, a flexible disk, a hard disk, a magnetic tape, or any other magnetic medium, an optical disk or any other optical medium, a ROM (read-only memory), a RAM (random access memory), a cache memory, and / or any other memory chip or cartridge, and / or any other medium from which a computer can read data, instructions, and / or code. The non-transitory storage device 1010 can be removable from the interface. The non-transitory storage device 1010 can have data / programs (including instructions) / code for implementing the above-described methods and steps. The computing device 1000 can also include a communication device 1012. The communication device 1012 can be any type of device or system that enables communication with external devices and / or with a network, and can include, but is not limited to, a modem, a network card, an infrared communication device, a wireless communication device, and / or a chipset, such as a BluetoothTM device, a 1302.11 device, a WiFi device, a WiMax device, a cellular communication device, and / or the like.

[0060] The computing device 1000 may also include a working memory 1014, which can be any type of working memory that can store programs (including instructions) and / or data useful for the operation of the processor 1004, and may include, but is not limited to, random access memory and / or read-only memory devices.

[0061] Software elements (programs) may be located in the working memory 1014, including but not limited to an operating system 1016, one or more application programs 1018, drivers, and / or other data and code. Instructions for performing the above methods and steps may be included in one or more application programs 1018, and the above traffic data visualization device may be implemented by the processor 1004 reading and executing the instructions of one or more application programs 1018. The executable code or source code of the instructions of the software elements (programs) may be stored in a non-transitory computer-readable storage medium (such as the above storage device 1010), and when executed, may be deposited in the working memory 1014 (possibly compiled and / or installed). The executable code or source code of the instructions of the software elements (programs) may also be downloaded from a remote location.

[0062] It should also be understood that various variations can be made according to specific requirements. For example, custom hardware can also be used, and / or specific elements can be implemented using hardware, software, firmware, middleware, microcode, hardware description language, or any combination thereof. For example, some or all of the disclosed methods and devices can be implemented by programming hardware (such as programmable logic circuits including field programmable gate arrays (FPGAs) and / or programmable logic arrays (PLAs)) using logic and algorithms according to the present disclosure, with assembly language or a hardware programming language (such as VERILOG, VHDL, C++).

[0063] Referring to Figures 6 to 10 , the specific structure of a tumor electric field therapy system including at least a pair of electrode patches manufactured according to the above method of the present invention will now be described. It should be understood that the target electrode positions determined by the computer simulation method of the present disclosure can be applied to the electrode patches of the tumor electric field therapy system. The electrode patches are manufactured after being specially designed according to the target electrode patch application positions determined by the method of the present invention.

[0064] Figure 6 A schematic structural diagram of a tumor electric field therapy system 200 is shown. As Figure 6 shown, the tumor electric field therapy system 200 includes an electric field generator 201, an adapter 202 electrically connected to the electric field generator 201, an animal experiment adapter board 203 electrically connected to the adapter 202, and at least one group of animal head electrodes 204 electrically connected to the animal experiment adapter board 203.

[0065] The electric field generator 201 generates at least one set of alternating electric signals with opposite polarities. In one example, the electric field generator 201 generates a set of alternating electric signals X1 and X2 with opposite polarities. The frequency range of the above-mentioned alternating electric signals X1 and X2 is between 150 kHz and 300 kHz, the intensity of the alternating electric signal is not less than 20 Vpp, and the application time of the alternating electric signal is not less than 72 h.

[0066] Reference Figure 7A and Figure 7B , the adapter 202 is used to transmit the alternating electric signals generated by the electric field generator 201 to the animal experiment adapter board 203. The animal experiment adapter board 203 is used to output the alternating electric signals transmitted by the adapter 202 and generated by the electric field generator 201 in multiple parallel groups, so that control experiments can be carried out synchronously to improve the accuracy and effectiveness of the basic research data and conclusions of animal experiments. The animal experiment adapter board 203 has at least one adapter board body 210, at least a pair of first connectors 220 provided on opposite sides of the adapter board body 210, multiple groups of second connectors 230, and a bracket 240 for suspending the adapter board body 210. Both the first connector 220 and the second connector 230 are electrically connected to the adapter board body 210. Each first connector 220 of the animal experiment adapter board 203 is electrically connected to a corresponding alternating electric signal transmitted by the adapter 202 through a corresponding cable (not shown). Different first connectors 220 transmit different alternating electric signals. Each second connector 230 is connected to all the first connectors 220 through the adapter board body 210. Each second connector 230 of the animal experiment adapter board 203 is electrically connected to a corresponding animal head electrode 204 respectively, so as to transmit the alternating electric signals in parallel to the corresponding animal head electrode 204 to act on the head of a mouse for animal experiments on tumor electric field therapy.

[0067] In one example, the animal experiment adapter board 203 has a pair of first connectors 220, where one first connector 220 transmits the alternating electric signal X1 and the other transmits the alternating electric signal X2. The animal experiment adapter board 203 has 10 second connectors 230 connected in parallel to the alternating electric signals X1 and X2, so as to realize the parallel output of the alternating electric signals X1 and X2 in 5 paths, enabling multiple animals to conduct experiments simultaneously under the electric field with the same parameters and improving the accuracy of the experiment.

[0068] In one example, the first connector 220 is pluggably connected to a corresponding cable (not shown), and the cable (not shown) connected to the first connector 220 is pluggably connected to the adapter 202. The second connector 230 is pluggably connected to a corresponding part of the animal head electrode 204. The first connector 220 has a plurality of first sockets 221, one of the first sockets 221 is connected to an alternating electric signal, and the remaining first sockets 221 are reserved sockets, which may not conduct signals or electricity, or may be used to configure a temperature monitoring circuit. The second connector 230 has a plurality of second sockets 231, two of the second sockets 231 are used to connect a set of alternating electric signals X1 and X2, and the remaining second sockets 231 are reserved sockets, which may not conduct signals or electricity, or may be used to configure a temperature monitoring circuit.

[0069] In summary, the electric field generator 201 generates a set of alternating electric signals X1 and X2 with opposite polarities, and the alternating electric signals X1 and X2 are routed through the adapter 202, the animal experiment adapter board 203, and the corresponding animal head electrode 204. The animal head electrode 204 is affixed to the corresponding body surface of the mouse head, and a set of alternating electric signals with opposite polarities generated by the electric field generator 201 are applied to the mouse head, and an alternating electric field is formed on the mouse head for tumor electric field therapy. In other examples, the tumor electric field therapy system 200 may not be provided with the adapter 202, and the electric field generator 201 is directly electrically connected to the animal experiment adapter board 203, and a set of alternating electric signals with opposite polarities generated by the electric field generator 201 are directly transmitted to the animal experiment adapter board 203.

[0070] As Figure 8 shown, the animal head electrode 204 is used for in-vivo experiments on animal head tumors, including: paired electrode functional components 10, a cable assembly 20 electrically connected to each electrode functional component 10, and a backing 30 and an adhesive 40 respectively disposed on opposite sides of the corresponding electrode functional component 10. The adhesive 40 of the animal head electrode 204 is affixed to the corresponding body surface of the mouse head, and the corresponding electrode functional component 10 is firmly configured on the corresponding body surface of the mouse head through the backing 30. The cable assembly 20 is electrically connected to the animal experiment adapter board 203 to transmit the alternating electric signal generated by the electric field generator 201 to the electrode functional component 10 affixed to the corresponding body surface of the mouse head, so as to form an alternating electric field on the mouse head for tumor electric field therapy.

[0071] As Figure 9As shown, each electrode functional component 10 includes a flexible circuit board 11, a dielectric element 12 and a first insulating support plate 13 provided on opposite sides of the flexible circuit board 11. The flexible circuit board 11 includes a main body portion 113 and a wiring portion 114 horizontally and laterally extending from the main body portion 113. The dielectric element 12 and the first insulating support plate 13 are respectively located on opposite sides of the main body portion 113 of the flexible circuit board 11. The dielectric element 12 is electrically connected to the main body portion 113 of the flexible circuit board 11, so that the animal head electrode 204 transmits the alternating electric signal generated by the electric field generator 201 to the body surface corresponding to the mouse head through its dielectric element 12, and then an alternating electric field for tumor electric field therapy is formed on the mouse head. A circular conductive core 111 is provided on one surface of the main body portion 113 facing the dielectric element 12. The dielectric element 12 is electrically connected to the conductive core 111 of the main body portion 113 through a conductive bonding material. The conductive bonding material is a solder material or a conductive adhesive. The dielectric element 12 is made of a high dielectric material, which can block the conduction of direct current and allow the conduction of alternating current. Preferably, in this example, the dielectric element 12 is a dielectric ceramic sheet.

[0072] As Figure 10 shown, a circular metal layer 121 is attached to the middle of one surface of the dielectric element 12 facing the conductive core 111 of the main body portion 113 of the flexible circuit board 11, so as to facilitate welding the dielectric element 12 to the conductive core 111 of the main body portion 113 of the flexible circuit board 11 through a solder material. The edge of the metal layer 121 is spaced from the edge of the dielectric element 12, that is, the diameter of the metal layer 121 is smaller than the diameter of the dielectric element 12.

[0073] The first insulating support plate 13 is adhesively disposed on the surface of the main body portion 113 away from the dielectric element 12 to increase the mechanical strength of the main body portion 113 of the flexible circuit board 11. The thickness of the first insulating support plate 13 is 0.1 - 0.5 mm, so as to make the electrode functional component 10 thinner and lighter to adapt to animal experiments and facilitate the attachment of the animal head electrode 204. Preferably, the first insulating support plate 13 is made of polyimide material. The first insulating support plate 13 made of polyimide material has excellent mechanical properties and flexibility.

[0074] The dielectric element 12 and the first insulating support plate 13 are arranged in one-to-one correspondence along the thickness direction of the main body portion 113 of the flexible circuit board 11. Both the dielectric element 12 and the first insulating support plate 13 are circular sheet-like structures. The diameter of the first insulating support plate 13 is substantially the same as the diameter of the main body portion 113 of the flexible circuit board 11. The diameter of the dielectric element 12 is slightly smaller than the diameter of the main body portion 113 of the flexible circuit board 11. The range of the diameters of the first insulating support plate 13 and the main body portion 113 of the flexible circuit board 11 is 6 - 12 mm, so as to make the electrode functional component 10 thinner and lighter to adapt to animal experiments and facilitate the application of the animal head electrode 204. In this example, the diameters of the first insulating support plate 13 and the main body portion 113 of the flexible circuit board 11 are 6.7 mm. The range of the diameter of the dielectric element 12 is 4 - 10 mm. In this example, the diameter of the dielectric element 12 is 6 mm.

[0075] As Figure 11 shown, the wiring portion 114 of the flexible circuit board 11 is in a strip-like sheet structure, and the wiring portion 114 of the flexible circuit board 11 extends horizontally and laterally from the main body portion 113 of the flexible circuit board 11. The wiring portion 114 of the flexible circuit board 11 is electrically connected to the cable assembly 20. A conductive pad 112 is provided at one end of the wiring portion 114 of the flexible circuit board 11 away from the main body portion 113. The conductive pad 112 and the conductive core 111 are located on the same side surface of the flexible circuit board 11. A conductive trace 115 is connected between the conductive pad 112 and the conductive core 111. The conductive trace 115 is embedded inside the flexible circuit board 11 to electrically connect the conductive pad 112 and the conductive core 111. The conductive core 111 and the conductive pad 112 are serially connected through the conductive trace 115.

[0076] A second insulating support plate 14 is provided on the surface of the wiring portion 114 of the flexible circuit board 11 away from the conductive pad 112. The second insulating support plate 14 and the conductive pad 112 are arranged in one-to-one correspondence along the thickness direction of the wiring portion 114 of the flexible circuit board 11. The size of the second insulating support plate 14 is larger than the size of the conductive pad 112. The width of the second insulating support plate 14 is the same as the width of the wiring portion 114 of the flexible circuit board 11, and the width of the conductive pad 112 is smaller than the width of the wiring portion 114 of the flexible circuit board 11. The length of the second insulating support plate 14 is greater than the length of the conductive pad 112.

[0077] Similar to the first insulating support plate 13, the second insulating support plate 14 and the first insulating support plate 13 are located on the same side surface of the flexible circuit board 11, and the second insulating support plate 14 also increases the mechanical strength of the wiring portion 114 of the flexible circuit board 11. The material of the second insulating support plate 14 is the same as the material of the first insulating support plate 13. The thickness of the second insulating support plate 14 is the same as the thickness of the first insulating support plate 13.

[0078] The length of the wiring portion 114 of the flexible printed circuit board 11 is set according to the size of the experimental mouse, so as to better fix the animal head electrode 204 on the mouse head. The length of the wiring portion 114 of the flexible printed circuit board 11 ranges from 20 to 100 mm. The width of the wiring portion 114 of the flexible printed circuit board 11 ranges from 1 to 5 mm. In this example, the wiring portion 114 of the flexible printed circuit board 11 is 38 mm long and 2 mm wide. It should be noted that the length direction of the wiring portion 114 of the flexible printed circuit board 11 and the length direction of the second insulating support plate 14 are both consistent with the extending direction of the wiring portion 114.

[0079] As Figure 12 shown, the cable assembly 20 includes a pair of first cables 21 electrically connected to the corresponding electrode functional components 10, a conductive slip ring 23 electrically connected to the first cables 21, a pair of second cables 24 electrically connected to the conductive slip ring 23, and a pair of connectors 25 respectively electrically connected to the corresponding second cables 24. The numbers of the second cables 24 and the connectors 25 are both the same as the number of the first cables 21.

[0080] One end of the first cable 21 is welded to the conductive pad 112 provided on the flexible printed circuit board 11 of the electrode functional component 10, and the other end is electrically connected to the conductive slip ring 23. A section of heat shrinkable tube 22 is fixedly covered around the welding portion of the first cable 21 and the conductive pad 112. The heat shrinkable tube 22 plays an insulating and protective role for the welding portion of the first cable 21 and the conductive pad 112, preventing the welding portion of the first cable 21 and the conductive pad 112 from being exposed to contact with other conductive substances and causing a short circuit. The heat shrinkable tube 22 provides strength support for the welding portion of the first cable 21 and the conductive pad 112, preventing the welding portion of the first cable 21 and the conductive pad 112 from breaking. The heat shrinkable tube 22 is covered around the welding portion of the first cable 21 and the conductive pad 112, so as to prevent dust and water from entering the welding portion of the first cable 21 and the conductive pad 112.

[0081] A plurality of first cables 21 arranged in pairs are rotatably electrically connected to the corresponding second cables 24 through the conductive slip ring 23. The first cables 21 and the second cables 24 can both rotate around the central axis of the conductive slip ring 23 without causing the first cables 21 to be intertwined, which can prevent the first cables 21 from being intertwined when the animal head electrode 204 is attached to the skin surface of the mouse head and the mouse moves inside the mouse cage, thus affecting normal activities. The conductive slip ring 23 is fixedly arranged on the mouse cage (not shown).

[0082] The connector 25 is electrically connected to the animal experiment adapter board 203. The connector 25 is connected to the animal experiment adapter board 203 by plugging. Each connector 25 has a conductive terminal. Each conductive terminal is connected one-to-one with a different one of a set of signal output terminals corresponding to the animal experiment adapter board 203. The number of connectors 25 is consistent with the number of electrode functional components 10. In this example, the number of connectors 25 is 2, which are respectively used to electrically connect the electric field generator 201 to generate a different one of a set of alternating electrical signals X1 and X2 with opposite polarities.

[0083] The backing 30 is a mesh fabric. The preferred backing 30 is a non-woven fabric. One side surface of the backing 30 has a biocompatible adhesive. The electrode functional component 10 is centrally adhered to the backing 30 through a layer of biocompatible adhesive to enhance the adhesion of the corresponding part of the electrode functional component 10 to the mouse skin. The backing 30 has a main body 31 and a plurality of strips 32. The plurality of strips 32 are all extended in the direction outward from the center of the main body 31 to better wrap the electrode functional component 10 of the animal head electrode 204 to the surface of the mouse head skin. The main body 31 is roughly circular. The edge of the assembly of the first insulating support plate 13, the main body 113 of the flexible circuit board 11 and the dielectric element 12 is arranged in an interval shape with the edge of the main body 31 of the backing 30. The assembly of the first insulating support plate 13, the main body 113 of the flexible circuit board 11 and the dielectric element 12 is roughly located in the middle of the main body 31 of the backing 30. The plurality of strips 32 of the backing 30 are arranged in a staggered manner with the connection portion 114 of the flexible circuit board 11. In this example, there are four strips 32 of the backing 30. The four strips 32 of the backing 30 are arranged in a substantially "cross" shape.

[0084] The adhesive member 40 has double-sided adhesiveness. The adhesive member 40 is arranged in a circular sheet shape, and its size is slightly larger than the size of the dielectric element 12. The adhesive member 40 covers the surface of the dielectric element 12 on one side away from the flexible support plate 11. The adhesive member 40 is applied to the surface skin of the mouse's head as a pasting layer to keep the skin surface moist and relieve local pressure. Preferably, the adhesive member 40 is a conductive hydrogel, which can serve as a conductive medium.

[0085] Although the present disclosure has been described and illustrated in detail in the accompanying drawings and the foregoing description, such description and illustration shall be regarded as illustrative and schematic rather than restrictive; the present disclosure is not limited to the disclosed embodiments. By studying the drawings, the disclosure and the appended claims, those skilled in the art can understand and implement variations of the disclosed embodiments when practicing the claimed subject matter. In the claims, the word "comprising" does not exclude other elements or steps not listed, the indefinite article "a" or "an" does not exclude a plurality, and the term "plurality" means two or more. The mere fact that certain measures are recited in mutually different dependent claims does not indicate that a combination of these measures cannot be used to advantage.

Claims

1. A computer simulation method for determining the position of an electrode patch, comprising: obtaining a mouse simulation model obtained by three-dimensional reconstruction of a mouse with a brain tumor; successively setting simulation electrode patch pairs at multiple pairs of candidate positions within the head region of the mouse simulation model, with a simulation alternating current signal applied to the simulation electrode patch pairs; for each pair of candidate positions among the multiple pairs of candidate positions, recording the electric field strength value of the simulation electric field established between the simulation electrode patch pairs when the simulation electrode patch pairs are set at this pair of candidate positions; selecting, from the multiple pairs of candidate positions, a pair of candidate positions with the maximum electric field strength value as the target electrode patch position; and determining an electrode patch corresponding to the target electrode patch position according to the target electrode patch position.

2. The computer simulation method according to claim 1, wherein each pair of candidate positions includes a first position and a second position, and the first position and the second position are spaced apart from each other.

3. The computer simulation method according to claim 2, wherein the first position is located between the left ear and the left eye of the mouse simulation model, and the second position is located between the right ear and the right eye of the mouse simulation model.

4. The computer simulation method according to claim 1, wherein the simulation alternating current signal includes a first alternating current signal and a second alternating current signal with opposite polarities, and the first alternating current signal and the second alternating current signal are respectively applied to two simulation electrode patches in the simulation electrode patch pair.

5. The computer simulation method according to claim 4, wherein the first alternating current signal and the second alternating current signal satisfy at least one of the following conditions: the frequency is between 150 kHz and 300 kHz, the intensity is greater than or equal to 20 Vpp, and the duration is greater than or equal to 72 hours.

6. The computer simulation method according to any one of claims 1-5, further comprising, before obtaining the mouse simulation model: imaging the mouse with a brain tumor using computed tomography technology to obtain three-dimensional imaging information; constructing the mouse simulation model based on the three-dimensional imaging information.

7. A computer simulation device for determining the position of an electrode patch, comprising: a first module for obtaining a mouse simulation model obtained by three-dimensional reconstruction of a mouse with a brain tumor; a second module for successively setting simulation electrode patch pairs at multiple pairs of candidate positions within the head region of the mouse simulation model, with a simulation alternating current signal applied to the simulation electrode patch pairs; a third module for, for each pair of candidate positions among the multiple pairs of candidate positions, recording the electric field strength value of the simulation electric field established between the simulation electrode patch pairs when the simulation electrode patch pairs are set at this pair of candidate positions; a fourth module for selecting, from the multiple pairs of candidate positions, a pair of candidate positions with the maximum electric field strength value as the target electrode patch position and the electrode patch corresponding to the target electrode patch position.

8. An electronic device, comprising: At least one processor; and a memory communicatively connected to the at least one processor; wherein the memory stores instructions executable by the at least one processor, and the instructions are executed by the at least one processor to enable the at least one processor to perform the method according to any one of claims 1-6.

9. A non-transitory computer-readable storage medium storing computer instructions, wherein the computer instructions are for causing the computer to perform the method according to any one of claims 1-6.

10. A computer program product comprising a computer program, wherein the computer program, when executed by a processor, implements the method according to any one of claims 1-6.

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