Fungicidal composition containing famoxadone and application thereof
By using oxazomedone and syrmosin as active ingredients in the bactericidal composition and preparing a suspension agent in combination with polycarboxylic acid dispersant, the problem of poor stability of the bactericidal composition in the prior art is solved, and good prevention and treatment effect and durability are achieved.
Patent Information
- Application Number
- CN202510349668.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-03-24
- Publication Date
- 2025-06-10
AI Technical Summary
The existing oxazomedone-containing bactericidal compositions have poor stability, resulting in reduced prevention and drug resistance problems.
The bactericidal composition using oxazomedone and lysyl methyl sulfone is prepared as a suspension agent in combination with a polycarboxylic acid dispersant. The polycarboxylic acid dispersant is made of allyl polyoxyethylene ether, α-methacrylic acid, alkenyl azobenzene and methyl acrylate through polymerization reaction.
The stability of the sterilization composition is improved, the anti-effect durability is extended, and the pesticide reduction and efficiency increase effect is achieved.
Smart Images
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Figure BDA0005325696430000102
Abstract
Description
Technical Field
[0001] The present invention belongs to the technical field of bactericidal compositions, and particularly relates to a bactericidal composition containing famoxadone and its application. Background Art
[0002] Famoxadone, 3-anilino-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazoline-2,4-dione, an energy inhibitor, i.e., a mitochondrial electron transport inhibitor, inhibits cytochrome C oxidoreductase in complex III and has protective, therapeutic, eradicative, penetrative, and systemic activities. Suitable crops include wheat, barley, peas, beets, rapeseed, grapes, potatoes, cucurbits, peppers, tomatoes, etc. It is mainly used to control important diseases in Ascomycetes, Basidiomycetes, and Oomycetes, such as powdery mildew, rust, glume blotch, net blotch, downy mildew, late blight, etc.
[0003] The site of action of famoxadone inhibiting mitochondrial electron transport is very single, and it is easy for pathogens to develop adaptive mutations to the agent, reducing or even invalidating the efficacy of the agent. Therefore, there are certain risks in the use of single agents.
[0004] In the actual process of agricultural production, the most likely problem in disease control is the generation of pathogen resistance. Long-term use of pesticides with a single site of action is likely to result in resistance, leading to a decline in control efficacy. In actual applications, a common method is to design and use different components for compounding to control resistant pathogens. When using different components for compounding, the actual application effect is used to judge whether a certain compounding has a synergistic, additive, or antagonistic effect. In the vast majority of cases, the compounding effect of pesticides is an additive effect. However, due to the different structures of the active ingredients in the compounded pesticides and the different persistences of the active ingredients, it is difficult to obtain better protection for crops that require a long-lasting control of diseases. Summary of the Invention
[0005] The purpose of the present invention is to provide a bactericidal composition containing famoxadone and its application to solve the problem of poor stability of the bactericidal composition.
[0006] The purpose of the present invention can be achieved by the following technical solutions:
[0007] In the first aspect of the present application, a bactericidal composition containing famoxadone is provided, the active ingredients are famoxadone and metalaxyl-M, and the mass ratio of famoxadone to metalaxyl-M is 1:1 - 3; the dosage form of the bactericidal composition is a suspension concentrate, and the suspension concentrate is added with a polycarboxylic acid dispersant, and the mass fraction of the polycarboxylic acid dispersant in the suspension concentrate is 3% - 5%, and the mass fraction of the active ingredients is 30%; the polycarboxylic acid dispersant is made by the polymerization reaction of allyl polyoxyethylene ether, α-methylacrylic acid, alkenyl azobenzene, and methyl acrylate.
[0008] In some possible implementation manners, the molar ratio of the amounts of allyl polyoxyethylene ether, α-methylacrylic acid, alkenyl azobenzene and methyl acrylate is 3:1:0.5 - 0.8:0.2.
[0009] In some possible implementation manners, the polycarboxylate dispersant is prepared by the following steps:
[0010] Dissolve allyl polyoxyethylene ether, α-methylacrylic acid, alkenyl azobenzene and methyl acrylate in methanol to obtain a monomer mixture solution; dissolve the chain transfer agent in methanol and water, heat up to 85 - 90 °C, and start to simultaneously dropwise add the monomer mixture solution and the initiator solution. After the dropping is completed, keep the temperature at 90 °C for heat preservation reaction for 2 h. After the reaction is completed, neutralize the reaction solution with an aqueous sodium hydroxide solution, and rotary evaporate to remove methanol and water to obtain the polycarboxylate dispersant.
[0011] In some possible implementation manners, the amount of the chain transfer agent is 1% - 2% of the total mass of the monomers; the amount of the initiator is 1% - 2% of the total mass of the monomers.
[0012] In some possible implementation manners, the suspending agent further includes 2% - 3% thickener and 5% - 6% antifreeze.
[0013] In some possible implementation manners, the thickener is at least one of xanthan gum, carboxymethyl cellulose and arabic gum.
[0014] In some possible implementation manners, the antifreeze is at least one of ethylene glycol, glycerol, propylene glycol and glycerin.
[0015] In some possible implementation manners, the alkenyl azobenzene is prepared by the following steps:
[0016] Add 4-hydroxyazobenzene to an alkaline aqueous solution, dropwise add a dispersion of bromoolefin and ethanol, heat under reflux for 4 - 5 h. After the reaction is completed, neutralize with hydrochloric acid, and obtain alkenyl azobenzene after washing with water and drying;
[0017] The molar ratio of the amounts of 4-hydroxyazobenzene and bromoolefin is 1:1 - 1.1;
[0018] The dosage ratio of 4-hydroxyazobenzene and the alkaline aqueous solution is 1 g:10 mL;
[0019] The dosage ratio of bromoolefin and ethanol in the dispersion of bromoolefin and ethanol is 1:10 mL;
[0020] The alkaline aqueous solution is a mixture of a potassium hydroxide aqueous solution with a mass fraction of 9% - 11% and potassium carbonate, and the dosage ratio is 10 mL:0.5 - 0.6 g.
[0021] In some possible implementation manners, the bromoolefin is at least one of allyl bromide, 4-bromo-1-butene, 6-bromo-1-hexene, 7-bromo-1-heptene, and 8-bromo-1-octene.
[0022] The second aspect of the present application provides an application of a bactericidal composition containing famoxadone in pesticides.
[0023] Advantages of the present invention:
[0024] The bactericidal composition containing famoxadone in the present application has good stability, has good control effects, and the control effects are persistent. It also has the effects of reducing the amount of pesticides and increasing efficiency. Specific embodiments
[0025] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts belong to the scope of protection of the present invention.
[0026] Obviously, the following description is only some examples or embodiments of the present application. For those of ordinary skill in the art, without making creative efforts, the present application can also be applied to other similar scenarios. In addition, it can also be understood that although the efforts made in this development process may be complex and lengthy, for those of ordinary skill in the art related to the content disclosed in the present application, some design, manufacturing, or production changes based on the technical content disclosed in the present application are only conventional technical means and should not be understood as the content disclosed in the present application being insufficient.
[0027] However, there will be cases where unnecessary detailed descriptions are omitted. For example, there are cases where detailed descriptions of well-known matters are omitted and repeated descriptions of actually identical structures are omitted. This is to avoid the following description from becoming unnecessarily lengthy and to facilitate the understanding of those skilled in the art. In addition, the following description is provided for those skilled in the art to fully understand the present application and is not intended to limit the subject matter recited in the claims.
[0028] If there is no special description, all the implementation manners and optional implementation manners of the present application can be combined with each other to form new technical solutions. All the technical features and optional technical features of the present application can be combined with each other to form new technical solutions.
[0029] The first aspect of the embodiments of the present application provides a bactericidal composition containing famoxadone, and the active ingredients are famoxadone and metalaxyl-M. The mass ratio of famoxadone to metalaxyl-M is 1:1 - 3;
[0030] The dosage form of the bactericidal composition is a suspension agent, and a polycarboxylic acid dispersant is added to the suspension agent. The mass fraction of the polycarboxylic acid dispersant in the suspension agent is 3% - 5%, and the mass fraction of the active ingredient is 30%; the polycarboxylic acid dispersant is made by polymerizing allyl polyoxyethylene ether, α-methylacrylic acid, alkenyl azobenzene and methyl acrylate.
[0031] In some specific embodiments, the molar ratio of the amounts of allyl polyoxyethylene ether, α-methylacrylic acid, alkenyl azobenzene and methyl acrylate is 3:1:0.5 - 0.8:0.2.
[0032] In some specific embodiments, the polycarboxylic acid dispersant is prepared by the following steps:
[0033] Dissolve allyl polyoxyethylene ether, α-methylacrylic acid, alkenyl azobenzene and methyl acrylate in methanol to obtain a monomer mixture; dissolve ammonium persulfate as an initiator in water to obtain an initiator solution;
[0034] Using dodecyl mercaptan as a chain transfer agent, dissolve it in methanol and water, heat up to 85 - 90 °C, and start to simultaneously dropwise add the monomer mixture and the initiator solution. After the dropping is completed, keep the temperature at 90 °C for 2 h for heat preservation reaction. After the reaction is completed, neutralize the reaction solution with an aqueous sodium hydroxide solution, and rotary evaporate to remove methanol and water to obtain the polycarboxylic acid dispersant.
[0035] In some specific embodiments, the amount of the chain transfer agent is 1% - 2% of the total mass of the monomers; the amount of the initiator is 1% - 2% of the total mass of the monomers;
[0036] In some specific embodiments, the suspension agent further includes a thickener with a mass fraction of 2% - 3% and an antifreeze with a mass fraction of 5% - 6%.
[0037] In some specific embodiments, the thickener is at least one of xanthan gum, carboxymethyl cellulose, and arabic gum.
[0038] In some specific embodiments, the antifreeze is at least one of ethylene glycol, glycerol, propylene glycol, and glycerin.
[0039] In some specific embodiments, alkenyl azobenzene is prepared by the following steps:
[0040] Add 4-hydroxyazobenzene to an alkaline aqueous solution, dropwise add a dispersion of bromoolefin and ethanol, heat under reflux for 4 - 5 h. After the reaction is completed, neutralize with hydrochloric acid, and obtain alkenyl azobenzene after washing with water and drying.
[0041] In some specific embodiments, the molar ratio of the amounts of 4-hydroxyazobenzene and bromoolefin is 1:1 - 1.1;
[0042] The dosage ratio of 4-hydroxyazobenzene to the alkaline aqueous solution is 1 g: 10 mL;
[0043] In the dispersion of bromoolefin and ethanol, the dosage ratio of bromoolefin to ethanol is 1: 10 mL;
[0044] The alkaline aqueous solution is a mixture of potassium hydroxide aqueous solution with a mass fraction of 9% - 11% and potassium carbonate, and the dosage ratio is 10 mL: 0.5 - 0.6 g.
[0045] In some specific embodiments, the bromoolefin is at least one of allyl bromide, 4-bromo-1-butene, 6-bromo-1-hexene, 7-bromo-1-heptene, and 8-bromo-1-octene.
[0046] The second aspect of the embodiments of the present application provides an application of a fungicidal composition containing famoxadone in pesticides.
[0047] The following is specifically described in conjunction with the examples.
[0048] Example 1
[0049] This example provides a fungicidal composition containing famoxadone. The dosage form of the fungicidal composition is a suspension concentrate, wherein the active ingredients are famoxadone and metalaxyl-M, the dispersant is a polycarboxylic acid dispersant, the mass fraction of the polycarboxylic acid dispersant in the suspension concentrate is 3%, the mass fraction of the active ingredients is 30%, the thickener is 2%, and the antifreeze is 5%; the mass ratio of famoxadone to metalaxyl-M is 1: 1; wherein the polycarboxylic acid dispersant is prepared by the following steps:
[0050] According to the molar ratio of 4-hydroxyazobenzene to bromoolefin being 1: 1; adding 4-hydroxyazobenzene to the alkaline aqueous solution, dropping the dispersion of bromoolefin and ethanol, heating under reflux for 4 h, after the reaction is completed, neutralizing with hydrochloric acid, and obtaining alkenyl azobenzene through washing with water and drying. The dosage ratio of 4-hydroxyazobenzene to the alkaline aqueous solution is 1 g: 10 mL; in the dispersion of bromoolefin and ethanol, the dosage ratio of bromoolefin to ethanol is 1: 10 mL; the alkaline aqueous solution is a mixture of potassium hydroxide aqueous solution with a mass fraction of 9% and potassium carbonate, and the dosage ratio is 10 mL: 0.5 g. The bromoolefin is selected as 4-bromo-1-butene.
[0051] Dissolve allyl polyoxyethylene ether (APEG-400), α-methylacrylic acid, vinyl azobenzene and methyl acrylate in methanol to obtain a monomer mixture; dissolve ammonium persulfate as an initiator in water to obtain an initiator solution; use dodecyl mercaptan as a chain transfer agent, dissolve it with methanol and water, heat up to 88 °C, and start to simultaneously dropwise add the monomer mixture and the initiator solution. After the dropping is completed, keep the temperature at 90 °C for 2 h for the reaction. After the reaction is completed, neutralize the reaction solution with an aqueous sodium hydroxide solution, and rotary evaporate to remove methanol and water to obtain a polycarboxylic acid dispersant. The dosage of the chain transfer agent is 1% of the total mass of the monomers; the dosage of the initiator is 1% of the total mass of the monomers; the molar ratio of the dosages of allyl polyoxyethylene ether, α-methylacrylic acid, vinyl azobenzene and methyl acrylate is 3:1:0.6:0.2.
[0052] The bactericidal composition containing oxfentanil is prepared by the following steps: Add oxfentanil, metalaxyl-M, polycarboxylic acid dispersant, thickener (xanthan gum) and antifreeze (ethylene glycol) into water (make up to 100% with water), and obtain a bactericidal composition containing oxfentanil after dispersion.
[0053] Example 2
[0054] The difference between this example and Example 1 lies in the different preparation process of the polycarboxylic acid dispersant. Specifically: Dissolve allyl polyoxyethylene ether, α-methylacrylic acid, vinyl azobenzene and methyl acrylate in methanol to obtain a monomer mixture; dissolve ammonium persulfate as an initiator in water to obtain an initiator solution; use dodecyl mercaptan as a chain transfer agent, dissolve it with methanol and water, heat up to 88 °C, and start to simultaneously dropwise add the monomer mixture and the initiator solution. After the dropping is completed, keep the temperature at 90 °C for 2 h for the reaction. After the reaction is completed, neutralize the reaction solution with an aqueous sodium hydroxide solution, and rotary evaporate to remove methanol and water to obtain a polycarboxylic acid dispersant. The dosage of the chain transfer agent is 1% of the total mass of the monomers; the dosage of the initiator is 1% of the total mass of the monomers; the molar ratio of the dosages of allyl polyoxyethylene ether, α-methylacrylic acid, vinyl azobenzene and methyl acrylate is 3:1:0.5:0.2. The other raw materials and the preparation process are the same as those in Example 1.
[0055] Example 3
[0056] The difference between this example and Example 1 lies in the different preparation process of the polycarboxylic acid dispersant. Specifically: Allyl polyoxyethylene ether, α-methylacrylic acid, vinyl azobenzene and methyl acrylate are dissolved in methanol to obtain a monomer mixture; Ammonium persulfate is used as an initiator and dissolved in water to obtain an initiator solution; Dodecyl mercaptan is used as a chain transfer agent, dissolved in methanol and water, heated to 88 °C, and then the monomer mixture and the initiator solution are simultaneously added dropwise. After the addition is completed, the reaction is carried out under insulation at 90 °C for 2 h. After the reaction is completed, the reaction solution is neutralized with an aqueous sodium hydroxide solution, and methanol and water are removed by rotary evaporation to obtain the polycarboxylic acid dispersant. The dosage of the chain transfer agent is 1% of the total mass of the monomers; the dosage of the initiator is 1% of the total mass of the monomers; the molar ratio of the dosages of allyl polyoxyethylene ether, α-methylacrylic acid, vinyl azobenzene and methyl acrylate is 3:1:0.8:0.2. The remaining raw materials and the preparation process are the same as those in Example 1.
[0057] Example 4
[0058] This example provides a bactericidal composition containing famoxadone. The difference between this example and Example 1 lies in that the dosage form of the bactericidal composition is a suspension agent, wherein the active ingredients are famoxadone and metalaxyl-M, the dispersant is a polycarboxylic acid dispersant, the mass fraction of the polycarboxylic acid dispersant in the suspension agent is 4%, and the mass fraction of the active ingredients is 30%; the mass ratio of famoxadone to metalaxyl-M is 1:1. The remaining raw materials and the preparation process are the same as those in Example 1.
[0059] Example 5
[0060] This example provides a bactericidal composition containing famoxadone. The difference between this example and Example 1 lies in that the dosage form of the bactericidal composition is a suspension agent, wherein the active ingredients are famoxadone and metalaxyl-M, the dispersant is a polycarboxylic acid dispersant, the mass fraction of the polycarboxylic acid dispersant in the suspension agent is 5%, and the mass fraction of the active ingredients is 30%; the mass ratio of famoxadone to metalaxyl-M is 1:1. The remaining raw materials and the preparation process are the same as those in Example 1.
[0061] Example 6
[0062] This example provides a bactericidal composition containing famoxadone. The dosage form of the bactericidal composition is a suspension agent, wherein the active ingredients are famoxadone and metalaxyl-M, the dispersant is a polycarboxylic acid dispersant, the mass fraction of the polycarboxylic acid dispersant in the suspension agent is 3%, the mass fraction of the active ingredients is 30%, the thickener is 3%, and the antifreeze is 6%; the mass ratio of famoxadone to metalaxyl-M is 1:1; wherein the polycarboxylic acid dispersant is prepared by the following steps:
[0063] According to the molar ratio of 4-hydroxyazobenzene to bromoolefin being 1:1; 4-hydroxyazobenzene was added to an alkaline aqueous solution, and a dispersion of bromoolefin and ethanol was added dropwise. After heating under reflux for 5 h, after the reaction ended, it was neutralized with hydrochloric acid, washed with water, and dried to obtain alkenyl azobenzene. The dosage ratio of 4-hydroxyazobenzene to the alkaline aqueous solution was 1 g:10 mL; the dosage ratio of bromoolefin to ethanol in the dispersion of bromoolefin and ethanol was 1:10 mL; the alkaline aqueous solution was a mixture of potassium hydroxide aqueous solution with a mass fraction of 11% and potassium carbonate, and the dosage ratio was 10 mL:0.6 g. The bromoolefin selected was 4-bromo-1-butene.
[0064] Allyl polyoxyethylene ether, α-methylacrylic acid, alkenyl azobenzene, and methyl acrylate were dissolved in methanol to obtain a monomer mixture; ammonium persulfate was used as an initiator and dissolved in water to obtain an initiator solution; dodecyl mercaptan was used as a chain transfer agent, dissolved in methanol and water, heated to 88 °C, and then the monomer mixture and the initiator solution were simultaneously added dropwise. After the addition was completed, the reaction was carried out under insulation at 90 °C for 2 h. After the reaction ended, the reaction solution was neutralized with an aqueous sodium hydroxide solution, and methanol and water were removed by rotary evaporation to obtain a polycarboxylic acid dispersant. The dosage of the chain transfer agent was 2% of the total mass of the monomers; the dosage of the initiator was 2% of the total mass of the monomers; the molar ratio of allyl polyoxyethylene ether, α-methylacrylic acid, alkenyl azobenzene, and methyl acrylate was 3:1:0.6:0.2.
[0065] The fungicidal composition containing oxfendazole was prepared by the following steps: Oxfendazole, metalaxyl-M, polycarboxylic acid dispersant, thickener (xanthan gum), and antifreeze (ethylene glycol) were added to water (made up to 100% with water), and after dispersion, a fungicidal composition containing oxfendazole was obtained. The remaining raw materials and the preparation process were the same as those in Example 1.
[0066] Comparative Example 1
[0067] Compared with Example 1, the difference in this comparative example was that the preparation method of the polycarboxylic acid dispersant was different. Specifically:
[0068] Allyl polyoxyethylene ether, α-methylacrylic acid, and methyl acrylate were dissolved in methanol to obtain a monomer mixture; ammonium persulfate was used as an initiator and dissolved in water to obtain an initiator solution; dodecyl mercaptan was used as a chain transfer agent, dissolved in methanol and water, heated to 88 °C, and then the monomer mixture and the initiator solution were simultaneously added dropwise. After the addition was completed, the reaction was carried out under insulation at 90 °C for 2 h. After the reaction ended, the reaction solution was neutralized with an aqueous sodium hydroxide solution, and methanol and water were removed by rotary evaporation to obtain a polycarboxylic acid dispersant. The dosage of the chain transfer agent was 1% of the total mass of the monomers; the dosage of the initiator was 1% of the total mass of the monomers; the molar ratio of allyl polyoxyethylene ether, α-methylacrylic acid, and methyl acrylate was 3:1:0.8. The remaining raw materials and the preparation process were the same as those in Example 1.
[0069] Comparative Example 2
[0070] The difference between this comparative example and Example 1 lies in the different preparation methods of the polycarboxylate dispersant. Specifically:
[0071] Dissolve allyl polyoxyethylene ether, α-methylacrylic acid and vinyl azobenzene in methanol to obtain a monomer mixture; dissolve ammonium persulfate as an initiator in water to obtain an initiator solution; use dodecyl mercaptan as a chain transfer agent, dissolve it in methanol and water, heat up to 88 °C, and start to simultaneously dropwise add the monomer mixture and the initiator solution. After the dropping is completed, keep the temperature at 90 °C for 2 h for the reaction. After the reaction is completed, neutralize the reaction solution with an aqueous sodium hydroxide solution, and rotary evaporate to remove methanol and water to obtain the polycarboxylate dispersant. The dosage of the chain transfer agent is 1% of the total mass of the monomers; the dosage of the initiator is 1% of the total mass of the monomers; the molar ratio of the dosages of allyl polyoxyethylene ether, α-methylacrylic acid and vinyl azobenzene is 3:1:0.8. The remaining raw materials and the preparation process are the same as those in Example 1.
[0072] Perform performance tests on the stability of the azoxystrobin-containing bactericidal compositions prepared in Examples 1 - 6 and Comparative Examples 1 - 2. Take the samples in ampoules, seal them, and place them in an incubator at (25 °C) for 30 d. Measure the suspension rate of the suspending agent before and after storage. The results are shown in Table 1:
[0073] Table 1
[0074]
[0075]
[0076] As can be seen from Table 1, the azoxystrobin-containing bactericidal composition prepared by the present invention has good dispersibility and good stability. In Comparative Example 1, the hydrophobic monomer in the prepared polycarboxylate dispersant is only methyl acrylate, and in Comparative Example 2, the hydrophobic monomer is only vinyl azobenzene, resulting in a decrease in dispersion and stability performance. When the proportion of vinyl azobenzene in Comparative Example 2 is relatively high, it will limit the movement of the polymer chain segments, reduce the flexibility of the chain, and affect the stability and dispersibility.
[0077] Record the control effect of grape downy mildew. Dilute and apply the drug according to 150 g per hectare (low concentration) or 200 g per hectare (low concentration) of the active ingredient, record the control effect 7 d and 14 d after administration, and set a clear water control. Each treatment has 4 replicates and is arranged in a randomized block design. Among them, the control effect of the clear water control group at 7 d is 5.5%, and the control effect of the clear water control group at 14 d is 7.8%.
[0078] The results are shown in Table 2 below:
[0079] Table 2
[0080]
[0081] According to the test results, it can be known that the bactericidal composition containing famoxadone prepared by the present invention has good control effects and the control effects are persistent. The reason is that an azobenzene structure (derived from vinyl azobenzene) is introduced into the polycarboxylic acid dispersant, which has good light stability, can better exert the action duration of the active ingredient, and can fully exert the action of the active ingredient even when the dosage of the active ingredient is small.
[0082] It should be noted that in this text, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the term "comprising", "including" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device comprising a series of elements not only includes those elements, but also includes other elements not expressly listed, or further includes elements inherent to such process, method, article or device.
[0083] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.
Claims
1. A bactericidal composition containing famoxadone, characterized in that: The active ingredients are oxadone and metalaxyl-M, and the mass ratio of oxadone to metalaxyl-M is 1:1-3; the dosage form of the bactericidal composition is a suspension, and a polycarboxylic acid dispersant is added to the suspension, the mass fraction of the polycarboxylic acid dispersant in the suspension is 3%-5%, and the mass fraction of the active ingredient is 30%; the polycarboxylic acid dispersant is prepared by polymerization reaction of allyl polyoxyethylene ether, α-methylacrylic acid, alkenyl azobenzene and methyl acrylate.
2. A bactericidal composition containing famoxadone according to claim 1, characterized in that: The molar ratio of allyl polyoxyethylene ether, α-methyl acrylic acid, alkenyl azobenzene and methyl acrylate is 3:1:0.5-0.8:0.
2.
3. A bactericidal composition containing famoxadone according to claim 1, characterized in that: The polycarboxylic acid dispersant is prepared by the following steps: Dissolve allyl polyoxyethylene ether, α-methylacrylic acid, alkenyl azobenzene and methyl acrylate in methanol to obtain a monomer mixture; dissolve the chain transfer agent in methanol and water, heat to 85-90°C, and start to drop the monomer mixture and initiator solution at the same time. After the dropwise addition is completed, keep the temperature at 90°C for 2 hours. After the reaction is completed, neutralize the reaction solution with sodium hydroxide aqueous solution, and remove methanol and water by rotary evaporation to obtain a polycarboxylic acid dispersant.
4. A bactericidal composition containing famoxadone according to claim 3, characterized in that: The amount of the chain transfer agent is 1% to 2% of the total weight of the monomers; the amount of the initiator is 1% to 2% of the total weight of the monomers.
5. A bactericidal composition containing famoxadone according to claim 1, characterized in that: The suspending agent also includes 2% to 3% of a thickener and 5% to 6% of an antifreeze agent.
6. A bactericidal composition containing famoxadone according to claim 5, characterized in that: The thickener is at least one of xanthan gum, carboxymethyl cellulose and gum arabic.
7. A bactericidal composition containing famoxadone according to claim 5, characterized in that: The antifreeze agent is at least one of ethylene glycol, glycerol, propylene glycol and glycerol.
8. A bactericidal composition containing famoxadone according to claim 1, characterized in that: Alkenyl azobenzene is prepared by the following steps: Add 4-hydroxyazobenzene to an alkaline aqueous solution, dropwise add a dispersion of bromoolefin and ethanol, heat and reflux for 4-5 hours, and after the reaction is completed, neutralize with hydrochloric acid, wash with water, and dry to obtain alkenyl azobenzene; The molar ratio of 4-hydroxyazobenzene to brominated olefin is 1:1-1.1; The dosage ratio of 4-hydroxyazobenzene and alkaline aqueous solution is 1g:10mL; The amount ratio of brominated olefin to ethanol in the dispersion of brominated olefin and ethanol is 1:10 mL; The alkaline aqueous solution is a mixture of a potassium hydroxide aqueous solution with a mass fraction of 9% to 11% and potassium carbonate, and the dosage ratio is 10mL:0.5-0.6g.
9. A bactericidal composition containing famoxadone according to claim 1, characterized in that: The brominated olefin is at least one of bromopropylene, 4-bromo-1-butene, 6-bromo-1-hexene, 7-bromo-1-heptene and 8-bromo-1-octene.
10. Use of the fungicidal composition containing famoxadone as claimed in any one of claims 1 to 9 in pesticides.