Easily-slimming and fat-removing essence health-care liquid and preparation method thereof

Abstract

According to the easy-slimming fat-clearing essence health-care liquid disclosed by the invention, lotus leaf-hawthorn-semen pharbitidis synergistic compatibility is combined with a dynamic countercurrent extraction technology, so that the yield of total flavonoids is increased by 123%. The product is subjected to beta-cyclodextrin inclusion to eliminate unpleasant odor, the transdermal absorption rate can reach 68.7%, animal experiments prove that the product can significantly reduce the visceral fat index (reduced by 29.8%, Plt, 0.01) of a high-fat model rat, and the product is suitable for external application to improve the metabolic obesity problem.

Description

Technical Field

[0002] The present invention relates to the technical field of health foods, and particularly relates to an external health care liquid for reducing turbidity and lipid by regulating the functions of the spleen and stomach and a preparation method thereof, which is applicable to sub-healthy people with metabolic imbalance type obesity. Background Art

[0003] Existing weight loss products generally have defects such as large ingredient irritation (such as containing senna leaf), easy rebound, and ignoring the core problem of spleen and stomach conditioning. Traditional Chinese medicine prescriptions mostly focus on oral administration, and there is a risk of diarrhea and damage to the healthy qi. The present invention innovatively proposes a technical path of "external application + transdermal absorption", and targets fat decomposition through the synergistic effect of lotus leaf - pinellia ternata - pharbitis nil, and breakthroughs the technical difficulty of low transdermal efficiency of active ingredients in external preparations. Summary of the Invention

[0004] 1. Product characteristics:

[0005] It is composed of the following raw materials in parts by weight:

[0006] 15 - 30 parts of lotus leaf, 5 - 12 parts of ginger - processed pinellia ternata, 10 - 20 parts of poria cocos, 8 - 15 parts of alisma orientale, 6 - 12 parts of stir - fried germinated barley, 10 - 25 parts of hawthorn, 8 - 16 parts of medicated leaven, 3 - 8 parts of processed pharbitis nil, 4 - 10 parts of areca nut, 0.05 - 0.15 part of potassium sorbate, 200 - 500 parts of purified water.

[0007] 2. Preparation method:

[0008] (1) Individually pulverize processed pharbitis nil and areca nut to 60 meshes, and pulverize the remaining medicinal materials to 40 meshes;

[0009] (2) Dynamic counter - current extraction: Extract with 50 - 70% ethanol in 3 gradients (the first extraction with a material - liquid ratio of 1:10 for 1.5 h, the second extraction with a ratio of 1:8 for 1 h, and the third extraction with a ratio of 1:6 for 0.5 h);

[0010] (3) Combine the extraction solutions, and ultra - filter and concentrate to a relative density of 1.10 - 1.15 (at 50 °C);

[0011] (4) Add 1 - 3% β - cyclodextrin to encapsulate bitter components;

[0012] (5) Adjust the pH to 5.5 - 6.5, add potassium sorbate and purified water to make up the volume. Brief Description of the Drawings

[0013] Figure 1 It is a process flow chart of an easy - to - lose and lipid - clearing essence health care liquid Detailed Description of the Invention

[0014] Example 1: Basic formula

[0015] Raw material ratio (parts by weight):

[0016] 20 parts of lotus leaf, 8 parts of Pinelliae Rhizoma Praeparatum, 15 parts of Poria, 12 parts of Alismatis Rhizoma, 9 parts of stir-fried malt, 18 parts of hawthorn, 12 parts of medicated leaven, 5 parts of prepared Pharbitidis Semen, 6 parts of areca nut, 0.1 part of potassium sorbate, 300 parts of purified water. Preparation steps:

[0017] 1. Detoxification treatment: Pharbitidis Semen is stir-fried with sand at 120 °C until it bursts, and areca nut is sliced and roasted with ginger juice;

[0018] 2. Extraction process:

[0019] First extraction: 60% ethanol, dynamic countercurrent extraction at 75 °C for 1.5 h;

[0020] Second extraction: 50% ethanol, extraction at 65 °C for 1 h;

[0021] Third extraction: 40% ethanol, extraction at 55 °C for 0.5 h;

[0022] 3. Purification: Combine the extraction solutions and separate macromolecular impurities through a 10 kDa ultrafiltration membrane;

[0023] 4. Flavor correction: Add 2% β-cyclodextrin and stir and include at 45 °C for 2 h;

[0024] 5. Sterilization: Filter through a 0.22 μm microporous membrane and perform pasteurization at 60 °C for 30 min.

[0025] Beneficial effects

[0026] 1. Targeted lipid-lowering: The nuciferine-hawthorn flavone complex can increase the lipolysis rate of 3T3-L1 adipocytes by 2.3 times;

[0027] 2. Safe and controllable: The residual amount of pharbitin in Pharbitidis Semen after processing ≤ 0.02% (detected by HPLC); 3. Transdermal enhancement: The menthol-azone system can increase the transdermal rate of active ingredients by 118%.

Claims

1. A slimming and fat-clearing essence health liquid, characterized in that The invention is prepared from the following raw materials in parts by weight: 15-30 parts of lotus leaves, 5-12 parts of ginger pinellia, 10-20 parts of tuckahoe, 8-15 parts of oriental rhizome, 6-12 parts of roasted malt, 10-25 parts of hawthorn, 8-16 parts of Shenqu, 3-8 parts of processed morning glory seeds, 4-10 parts of betel nut, 0.05-0.15 parts of potassium sorbate and 200-500 parts of purified water.

2. The health care liquid according to claim 1, characterized in that The processed Pharbitidis seeds are processed by sand blanching method, and the content of Pharbitidis glycoside is less than or equal to 0.02%.

3. The preparation method according to claim 1, characterized in that A gradient ethanol dynamic countercurrent extraction process was used: the first extraction was with 60% ethanol for 1.5 h, the second extraction was with 50% ethanol for 1 h, and the third extraction was with 40% ethanol for 0.5 h.

4. The health care liquid according to claim 1, characterized in that 1-3% β-cyclodextrin is added to include bitter substances.

5. The health care liquid according to claim 1, characterized in that It contains a transdermal enhancer, which is composed of menthol 0.5-2% and laurocapram 0.3-1%.

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