Noninvasive chronic abacterial prostatitis rat model making device

Through non-invasive local thermal stimulation and high-frequency vibration stimulation methods, a rat model of chronic nonbacterial prostatitis was constructed, which solved the problem of bacterial infection caused by puncture injection in the prior art, and improved the success rate of model construction and the ease of standardization promotion.

CN120189257AInactive Publication Date: 2025-06-24NANCHANG REPRODUCTIVE HOSPITAL (AFFILIATED HOSPITAL OF NANCHANG INST OF MEDICAL SCI)
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Patent Information

Application Number
CN202510599480.6
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-05-11
Publication Date
2025-06-24
Estimated Expiration
Not applicable · inactive patent

AI Technical Summary

Technical Problem

The existing rat model construction method for chronic nonbacterial prostatitis requires prostate puncture injection in rats, which can easily lead to bacterial infection, resulting in modeling failure or reduced success rate.

Method used

A rat model of chronic nonbacterial prostatitis was constructed using non-invasive local thermal stimulation combined with high-frequency vibration stimulation. The thermal stimulation and vibration frequency were controlled through a special device to avoid the infiltration of bacteria by puncture.

Benefits of technology

The non-invasive chronic non-bacterial prostatitis rat model was achieved, which improved the success rate and avoided the problems caused by bacterial infection, and the method was easier to standardize and promote.

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Abstract

The invention discloses a noninvasive chronic abacterial prostatitis rat model making device which comprises a multifunctional operation base, a lifting stand column, a rat posture adjusting mechanism, a rat fixing plate, a lifting support, a pitching angle adjusting mechanism and a rat prostate multi-mode stimulator. The lifting support is fixed on the base, the pitching angle adjusting mechanism is fixed on the lifting support, the rat prostate multi-mode stimulator is fixed on the pitching angle adjusting mechanism, the rat posture adjusting mechanism is fixed on the multifunctional operation base, and the rat fixing plate is fixed on the rat posture adjusting mechanism. According to the device, the chronic abacterial prostatitis rat model is constructed by combining prostate local thermal stimulation with prostate local high-frequency vibration stimulation, the prostate tissue of the rat is noninvasive in the whole modeling process, and the problem of modeling failure or low success rate caused by introduction of bacteria in the injection puncture process is avoided.
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Description

Technical Field

[0001] The present invention relates to the technical field of medical tools, and particularly relates to a non-invasive modeling device for a rat model of chronic non-bacterial prostatitis. Background Art

[0002] Chronic non-bacterial prostatitis accounts for about 90% of prostatitis, which refers to the chronic inflammation of the prostate caused by non-bacterial pathogenic microorganisms or non-infectious factors. At present, the etiology of chronic non-bacterial prostatitis is not clear clinically, but it is generally believed that it may be related to factors such as trauma, infection, abnormal urination function, neuropsychological factors, sex hormones, immune function, and oxidative stress. In current medical research, animal models play an important role, and constructing a rat model of chronic non-bacterial prostatitis is of great significance for the mechanism of action and drug research of chronic non-bacterial prostatitis.

[0003] Currently, the construction of a rat model of chronic non-bacterial prostatitis is mainly induced by chemical agents or biological agents. The chemical reagent induction method uses methods such as local injection of carrageenan into the prostate, local injection of Xiaozhiling into the prostate, local injection of glycerol into the prostate, local injection of formaldehyde-croton oil into the prostate, and local injection of 2% agarose into the prostate. The biological agent induction method uses methods such as preparing a rat model with male and female hormones and rat prostate protein extract supplemented with an adjuvant. For the above-mentioned modeling methods, whether it is the induction method of chemical agents or biological agents, the rat prostate needs to be punctured and injected, which is extremely easy to turn into bacterial prostatitis, resulting in modeling failure or a decrease in the modeling success rate. Summary of the Invention

[0004] In order to solve the above technical problems, the present invention provides a non-invasive modeling device for a rat model of chronic non-bacterial prostatitis. This device uses local thermal stimulation of the prostate combined with local high-frequency vibration stimulation of the prostate to construct a rat model of chronic non-bacterial prostatitis. During the entire modeling process, there is no trauma to the rat prostate tissue, avoiding the problem of introducing bacteria during the injection and puncture process, which may lead to modeling failure or a low success rate. This device provides a new means for modeling a rat model of chronic non-bacterial prostatitis. Through this device, the local thermal stimulation and vibration frequency of the prostate can be controlled, which is easier to standardize and promote compared with the preparation injection induction method.

[0005] In order to achieve the above technical effects, the present invention is realized through the following technical solutions: A non-invasive modeling device for a rat model of chronic non-bacterial prostatitis, comprising a multi-functional operation base, a lifting column, a rat posture adjustment mechanism, a rat fixing plate, a lifting support, a pitching angle adjustment mechanism, and a multi-modal stimulator for the rat prostate. The lifting column is fixed on the multi-functional operation base. The lifting support is arranged on the lifting column and can slide up and down along the lifting column. The pitching angle adjustment mechanism is fixed on the lifting support. The multi-modal stimulator for the rat prostate is fixed on the pitching angle adjustment mechanism. The rat posture adjustment mechanism is fixed on the multi-functional operation base. The rat fixing plate is fixed on the rat posture adjustment mechanism. The rat posture adjustment mechanism can adjust the horizontal position and pitching angle of the rat fixing plate.

[0006] Further, the multi-functional operation base includes a housing. On the front surface of the housing, there are a rat posture adjustment button and a multi-modal stimulator posture adjustment button for the rat prostate. Inside the housing, there are fixed a first storage battery, a first control circuit board, and a lifting drive motor. The rat posture adjustment button, the multi-modal stimulator posture adjustment button for the rat prostate, the first storage battery, and the lifting drive motor are all connected to the first control circuit board. The rat posture adjustment mechanism and the pitching angle adjustment mechanism are connected to the first control circuit board. On the rotating shaft of the lifting drive motor, there is fixed a lifting lead screw. The lifting lead screw is arranged in the lifting column and its top is hinged to the top plate of the lifting column. The lifting support includes a lifting slider and a lifting connecting plate. The lifting slider is threadedly connected to the lifting lead screw. The lifting slider extends out from the chute of the lifting column and is fixedly connected to the lifting connecting plate. The pitching angle adjustment mechanism is fixed on the lifting connecting plate.

[0007] Further, the rat posture adjustment mechanism includes a horizontal adjustment guide groove, a horizontal adjustment drive motor, a horizontal slider, an inclination angle adjustment plate, an inclination adjustment drive motor, and an inclination adjustment fixed shaft. The horizontal adjustment drive motor is fixed outside the end of the horizontal adjustment guide groove. The horizontal slider is T-shaped. The web of the horizontal slider is inserted into the horizontal adjustment guide groove and its two side wings are supported on the top of the two side grooves of the horizontal adjustment guide groove. The rotating shaft of the horizontal adjustment drive motor is fixedly connected with a horizontal lead screw. The horizontal lead screw passes through the horizontal slider and is threadedly connected to the horizontal slider. A pair of inclination angle adjustment plates are fixed on both sides of the top of the horizontal slider. The inclination adjustment drive motor is fixed outside the inclination angle adjustment plate. Between the two inclination angle adjustment plates, there is a rotating shaft fixedly connected to the rotating shaft of the inclination adjustment drive motor. The inclination adjustment fixed shaft is fixed on the top of the rotating shaft. The rat fixing plate is fixed at the end of the inclination adjustment fixed shaft.

[0008] Further, a number of threaded jacks are opened on the rat fixing plate. The threaded jacks are arranged on two diagonals of the rat fixing plate. On the threaded jacks, there are inserted screw rods. The rat is fixed on the rat fixing plate by ropes tied to the screw rods.

[0009] Furthermore, the pitch angle adjustment mechanism includes a pair of pitch angle adjustment plates, a pitch drive motor, and a pitch drive shaft. The pitch angle adjustment plates are fixed to both sides of the lifting connection plate. The pitch drive motor is fixed to the outside of the lifting connection plate. The pitch drive shaft is hinged between the pitch angle adjustment plates and fixedly connected to the rotating shaft of the pitch drive motor.

[0010] Furthermore, a processing chip, a power module, a battery power detection module, a charging switch module, a USB charging module, a digital-to-analog conversion module, a relay module, and a buzzer are fixed on the first control circuit board. The power module, the battery power detection module, the charging switch module, the digital-to-analog conversion module, and the buzzer are all connected to the processing chip. The relay module is connected to the digital-to-analog conversion module. The USB charging module is connected to the charging switch module. The power module, the battery power detection module, and the charging switch module are all connected to the first storage battery.

[0011] Furthermore, the multi-modal stimulator for rat prostate includes a cover plate, an enclosing plate, and a bottom plate. A display screen and operation buttons are fixed on the cover plate. An infrared radiation groove is formed on the bottom plate. An infrared radiation plate is inserted into the infrared radiation groove. A plurality of infrared radiation lamp beads are fixed on the infrared radiation plate. A second control circuit board, a second storage battery, and a vibration control relay are fixed on the bottom plate. A wire is led out from below the bottom plate, and the front end of the wire is connected to a vibrating rod. The vibrating rod is connected to the vibration control relay through the wire. The vibration control relay, the storage battery, and the infrared radiation lamp beads are all connected to the second control circuit board.

[0012] Furthermore, a processing chip, a power module, a constant current source drive module, and a digital-to-analog conversion module are fixed on the second control circuit board. The power module, the constant current source drive module, and the digital-to-analog conversion module are all connected to the processing chip. The vibration control relay is connected to the digital-to-analog conversion module. The infrared radiation lamp beads are connected to the constant current source drive module. The second storage battery is connected to the power module.

[0013] The beneficial effects of the present invention are as follows: The device uses local thermal stimulation of the prostate combined with local high-frequency vibration stimulation of the prostate to construct a rat model of chronic non-bacterial prostatitis. During the entire modeling process, there is no trauma to the rat prostate tissue, avoiding the problem of model failure or low success rate caused by bacteria introduced during the injection and puncture process. The device provides a new means for modeling a rat model of chronic non-bacterial prostatitis. Through this device, the local thermal stimulation and vibration frequency of the prostate can be controlled, which is easier to standardize and promote compared with the preparation injection induction method. Description of the Drawings

[0014] To more clearly illustrate the technical solutions of the embodiments of the present invention, the following will briefly introduce the drawings required for the description of the embodiments. Obviously, the drawings in the following description are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0015] Figure 1 is a schematic diagram of the overall structure of a non-invasive device for establishing a rat model of chronic non-bacterial prostatitis; Figure 2 is a schematic diagram of the component structure of a non-invasive device for establishing a rat model of chronic non-bacterial prostatitis; Figure 3 is a schematic diagram of the component structure of the rat posture adjustment mechanism; Figure 4 is a schematic diagram of the internal structure of the multifunctional operation base; Figure 5 is a schematic diagram of the structural layout of the first control circuit board; Figure 6 is a schematic diagram of the component structure of the rat prostate multimodal stimulator.

[0016] In the drawings, the list of components represented by each reference numeral is as follows: 1 - multifunctional operation base, 2 - lifting column, 3 - rat posture adjustment mechanism, 4 - rat fixing plate, 5 - lifting support, 6 - pitching angle adjustment mechanism, 7 - rat prostate multimodal stimulator, 11 - rat posture adjustment button, 12 - rat prostate multimodal stimulator posture adjustment button, 13 - base plate, 14 - first battery, 15 - first control circuit board, 16 - lifting drive motor, 21 - lifting lead screw, 31 - horizontal adjustment guide groove, 32 - horizontal adjustment drive motor, 33 - horizontal slider, 34 - tilt angle adjustment plate, 35 - tilt adjustment drive motor, 36 - tilt adjustment fixed shaft, 37 - horizontal lead screw, 41 - plate body, 42 - threaded jack, 43 - screw, 51 - lifting slider, 52 - lifting connecting plate, 61 - pitching angle adjustment plate, 62 - pitching drive motor, 63 - pitching drive shaft, 71 - stimulator body, 72 - vibrating rod, 73 - infrared radiation plate, 74 - infrared radiation lamp beads, 75 - second control circuit board, 76 - vibration control relay, 77 - second battery, 151 - processing chip, 152 - power module, 153 - power detection module, 154 - charging switch module, 155 - USB charging module, 156 - digital-to-analog conversion module, 157 - relay module, 158 - buzzer, 711 - bottom plate, 712 - enclosing plate, 713 - cover plate, 714 - display screen, 715 - operation button, 716 - infrared radiation groove. Detailed implementation manners

[0017] The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without making creative efforts shall fall within the protection scope of the present invention.

[0018] As Figure 1 shown, a non-invasive modeling device for a chronic non-bacterial prostatitis rat model includes a multi-functional operation base 1, a lifting column 2, a rat posture adjustment mechanism 3, a rat fixing plate 4, a lifting support 5, a pitching angle adjustment mechanism 6, and a rat prostate multi-modal stimulator 7. The lifting column 2 is fixed on the multi-functional operation base 1. The lifting support 5 is arranged on the lifting column 2 and can slide up and down along the lifting column 2. The pitching angle adjustment mechanism 6 is fixed on the lifting support 5. The rat prostate multi-modal stimulator 7 is fixed on the pitching angle adjustment mechanism 6. The rat posture adjustment mechanism 3 is fixed on the multi-functional operation base 1. The rat fixing plate 4 is fixed on the rat posture adjustment mechanism 3. The rat posture adjustment mechanism 3 can adjust the horizontal position and pitching angle of the rat fixing plate 4.

[0019] As Figure 2 shown, the multi-functional operation base includes a housing. On the front surface of the housing, there are a rat posture adjustment button 11 and a rat prostate multi-modal stimulator posture adjustment button 12. A first battery 14, a first control circuit board 15, and a lifting drive motor 16 are fixed in the housing. The rat posture adjustment button 11, the rat prostate multi-modal stimulator posture adjustment button 12, the first battery 14, and the lifting drive motor 16 are all connected to the first control circuit board 15. The rat posture adjustment mechanism 3 and the pitching angle adjustment mechanism 6 are connected to the first control circuit board 15. A lifting lead screw 21 is fixed on the rotating shaft of the lifting drive motor 16. The lifting lead screw 21 is arranged in the lifting column 2 and its top is hinged to the top plate of the lifting column 2. The lifting support 5 includes a lifting slider 51 and a lifting connecting plate 52. The lifting slider 51 is threadedly connected to the lifting lead screw 21. The lifting slider 51 extends out from the chute of the lifting column and is fixedly connected to the lifting connecting plate 52. The pitching angle adjustment mechanism 6 is fixed on the lifting connecting plate 52.

[0020] A plurality of threaded jacks 42 are formed on the rat fixing plate 4. The threaded jacks 42 are arranged on two diagonal lines of the rat fixing plate. A screw 43 is inserted into the threaded jack 42. The rat is fixed on the rat fixing plate by a rope tied to the screw.

[0021] As Figures 3 - 4As shown, the rat posture adjustment mechanism 3 includes a horizontal adjustment guide groove 31, a horizontal adjustment drive motor 32, a horizontal slider 33, an inclination angle adjustment plate 34, an inclination adjustment drive motor 35, and an inclination adjustment fixed shaft 36. The horizontal adjustment drive motor is fixed to the outer side of the end of the horizontal adjustment guide groove. The horizontal slider is T-shaped. The web of the horizontal slider is inserted into the horizontal adjustment guide groove, and the two side wings are supported on the top of the two side grooves of the horizontal adjustment guide groove. A horizontal lead screw 37 is fixedly connected to the rotating shaft of the horizontal adjustment drive motor 32. The horizontal lead screw passes through the horizontal slider and is threadedly connected to the horizontal slider. A pair of inclination angle adjustment plates are fixed to the two sides of the top of the horizontal slider. The inclination adjustment drive motor is fixed to the outer side of the inclination angle adjustment plate. A rotating shaft fixedly connected to the rotating shaft of the inclination adjustment drive motor is arranged between the two inclination angle adjustment plates. The inclination adjustment fixed shaft is fixed to the top of the rotating shaft. The rat fixing plate is fixed to the end of the inclination adjustment fixed shaft.

[0022] The pitch angle adjustment mechanism 6 includes a pair of pitch angle adjustment plates 61, a pitch drive motor 62, and a pitch drive shaft 63. The pitch angle adjustment plates are fixed to the two sides of the lifting connection plate. The pitch drive motor is fixed to the outer side of the lifting connection plate. The pitch drive shaft is hinged between the pitch angle adjustment plates and is fixedly connected to the rotating shaft of the pitch drive motor.

[0023] As Figure 5 As shown, a processing chip 151, a power supply module 152, a power quantity detection module 153, a charging switch module 154, a USB charging module 155, a digital-to-analog conversion module 156, a relay module 157, and a buzzer 158 are fixed on the first control circuit board. The power supply module, the power quantity detection module, the charging switch module, the digital-to-analog conversion module, and the buzzer are all connected to the processing chip. The relay module is connected to the digital-to-analog conversion module. The USB charging module is connected to the charging switch module. The power supply module, the power quantity detection module, and the charging switch module are all connected to the first storage battery.

[0024] The position, inclination angle of the rat fixing plate, and the height and pitch angle of the multi-modal stimulator for rat prostate can be adjusted through the rat posture adjustment button 11 and the posture adjustment button 12 of the multi-modal stimulator for rat prostate. After receiving the instruction, the processing chip will output the instruction to the digital-to-analog conversion module. The digital-to-analog conversion module will output the instruction value to the corresponding relay module 157. This relay module 157 will drive the lifting drive motor 16, the pitch drive motor, the horizontal adjustment drive motor 32, or the tilt adjustment drive motor 35. The lifting drive motor 16 will drive the lifting lead screw to rotate forward or backward, and the lifting support 5 threadedly connected to the lifting lead screw will slide up and down, thereby adjusting the height of the multi-modal stimulator for rat prostate. The pitch drive motor 62 will drive the pitch drive shaft to rotate forward or backward to adjust the pitch angle of the multi-modal stimulator for rat prostate 7. The horizontal adjustment drive motor 32 will drive the horizontal lead screw 37 to rotate forward or backward, and the horizontal slider 33 threadedly connected to the horizontal lead screw will move left and right to adjust the horizontal position of the rat fixing plate. The tilt adjustment drive motor 35 rotates forward or backward, and the tilt adjustment fixed shaft 36 will rotate so that the rat fixing plate tilts towards the multi-modal stimulator for rat prostate 7 to facilitate the infrared radiation light to irradiate the rat prostate part and the vibrating rod to be inserted into the rat rectum.

[0025] As Figure 6 shown, the multi-modal stimulator for rat prostate 7 includes a cover plate 713, an enclosing plate 712, and a bottom plate 711. A display screen 714 and operation buttons 715 are fixed on the cover plate. An infrared radiation groove 716 is opened on the bottom plate. An infrared radiation plate 73 is inserted into the infrared radiation groove. A plurality of infrared radiation lamp beads 74 are fixed on the infrared radiation plate. A second control circuit board 75, a second storage battery 77, and a vibration control relay 76 are fixed on the bottom plate. A wire is led out from below the bottom plate 711, and the front end of the wire is connected to a vibrating rod 72. The vibrating rod 72 is connected to the vibration control relay through the wire. The vibration control relay, the storage battery, and the infrared radiation lamp beads are all connected to the second control circuit board.

[0026] A processing chip, a power supply module, a constant current source drive module, and a digital-to-analog conversion module are fixed on the second control circuit board. The power supply module, the constant current source drive module, and the digital-to-analog conversion module are all connected to the processing chip. The vibration control relay is connected to the digital-to-analog conversion module. The infrared radiation lamp beads are connected to the constant current source drive module. The second storage battery is connected to the power supply module. The processing chip can receive the operation instructions of the operation buttons and output corresponding instructions to the constant current source drive module and the digital-to-analog conversion module. The constant current source drive module will drive the infrared radiation lamp beads to emit infrared radiation light. At the same time, the digital-to-analog conversion module will control the start and stop of the vibration of the vibrating rod 72 through the vibration control relay.

[0027] In this embodiment, the processing chip selects the STM32F103 type micro processing chip, the digital-to-analog conversion module selects the DAC0832 type digital-to-analog conversion chip, the power detection module selects the LTC2949 type power detection chip, the charging switch module selects the MOSFET transistor, the power supply module selects the AMS1117-3.3V power supply chip, the relay module selects the G5V-1 type micro relay, and the constant current source drive module selects the TX6122 type constant current source drive chip.

[0028] The specific application of this device is as follows: Fix the anesthetized rat on the rat fixing plate 4, and then adjust the water level position and tilt angle of the rat fixing plate 3 through the rat posture adjustment button 11 to facilitate the operation. After adjusting the position and lying angle of the rat, adjust the height of the lifting support 5 and the pitch angle of the pitch angle adjustment mechanism 6 through the rat prostate multi-modal stimulator posture adjustment button 12, so that the infrared radiation light emitted by the rat prostate multi-modal stimulator 7 irradiates the prostate area of the rat. At the same time, insert the vibrator 72 along the rectum of the rat and make the front end abut against the prostate. Set the irradiation time of the infrared radiation light and the vibration time of the vibrator through the operation button 715, and induce prostatitis in the rat through temperature stimulation and physical diagnosis stimulation, thereby constructing a chronic non-bacterial prostatitis rat model.

[0029] In the description of this specification, the descriptions referring to terms such as "one embodiment", "example", "specific example", etc. mean that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic expressions of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in a suitable manner in any one or more embodiments or examples.

Claims

1. A non-invasive chronic non-bacterial prostatitis rat model making device, characterized in that: The invention comprises a multifunctional operating base, a lifting column, a rat posture adjustment mechanism, a rat fixing plate, a lifting support, a pitch angle adjustment mechanism and a rat prostate multimodal stimulator, wherein the lifting column is fixed on the multifunctional operating base, the lifting support is arranged on the lifting column and can slide up and down along the lifting column, the pitch angle adjustment mechanism is fixed on the lifting support, the rat prostate multimodal stimulator is fixed on the pitch angle adjustment mechanism, the rat posture adjustment mechanism is fixed on the multifunctional operating base, the rat fixing plate is fixed on the rat posture adjustment mechanism, and the rat posture adjustment mechanism can adjust the horizontal position and pitch angle of the rat fixing plate.

2. A non-invasive chronic non-bacterial prostatitis rat modeling device according to claim 1, characterized in that: The multifunctional operating base includes a shell, and a rat posture adjustment button and a rat prostate multimodal stimulator posture adjustment button are arranged on the front of the shell, a first battery, a first control circuit board and a lifting drive motor are fixed in the shell, the rat posture adjustment button, the rat prostate multimodal stimulator posture adjustment button, the first battery and the lifting drive motor are all connected to the first control circuit board, the rat posture adjustment mechanism and the pitch angle adjustment mechanism are connected to the first control circuit board, a lifting screw is fixed on the rotating shaft of the lifting drive motor, the lifting screw is arranged in the lifting column and the top is hinged to the top plate of the lifting column, the lifting support includes a lifting slider and a lifting connecting plate, the lifting slider is threadedly connected to the lifting screw, the lifting slider extends from the slide groove of the lifting column and is fixedly connected to the lifting connecting plate, and the pitch angle adjustment mechanism is fixed on the lifting connecting plate.

3. A non-invasive chronic non-bacterial prostatitis rat modeling device according to claim 2, characterized in that: The rat posture adjustment mechanism includes a horizontal adjustment guide groove, a horizontal adjustment drive motor, a horizontal slider, a tilt angle adjustment plate, a tilt adjustment drive motor and a tilt adjustment fixed shaft. The horizontal adjustment drive motor is fixed to the outer side of the end of the horizontal adjustment guide groove. The horizontal slider is T-shaped. The web of the horizontal slider is inserted into the horizontal adjustment guide groove and the two side wing plates are supported on the top of the two side grooves of the horizontal adjustment guide groove. The rotating shaft of the horizontal adjustment drive motor is fixedly connected with a horizontal lead screw, which passes through the horizontal slider and is threadedly connected with the horizontal slider. A pair of tilt angle adjustment plates are fixed to the two sides of the top of the horizontal slider. The tilt adjustment drive motor is fixed to the outer side of the tilt angle adjustment plate. A rotating shaft fixedly connected to the rotating shaft of the tilt adjustment drive motor is arranged between the two tilt angle adjustment plates. The tilt adjustment fixed shaft is fixed to the top of the rotating shaft, and the rat fixing plate is fixed to the end of the tilt adjustment fixed shaft.

4. A non-invasive chronic non-bacterial prostatitis rat model making device according to any one of claims 1 to 3, characterized in that: The rat fixing plate is provided with a plurality of threaded jacks, which are arranged on two diagonal lines of the rat fixing plate. Screws are inserted into the threaded jacks, and the screws fix the rats on the rat fixing plate through ropes bolted thereon.

5. A non-invasive chronic non-bacterial prostatitis rat modeling device according to claim 4, characterized in that: The pitch angle adjustment mechanism includes a pair of pitch angle adjustment plates, a pitch drive motor and a pitch drive shaft. The pitch angle adjustment plates are fixed to both sides of the lifting connection plate, the pitch drive motor is fixed to the outer side of the lifting connection plate, and the pitch drive shaft is hinged between the pitch angle adjustment plates and fixedly connected to the rotating shaft of the pitch drive motor.

6. A non-invasive chronic non-bacterial prostatitis rat modeling device according to claim 4, characterized in that: A processing chip, a power supply module, a power detection module, a charging switch module, a USB charging module, a digital-to-analog conversion module, a relay module and a buzzer are fixed on the first control circuit board; the power supply module, the power detection module, the charging switch module, the digital-to-analog conversion module and the buzzer are all connected to the processing chip, the relay module is connected to the digital-to-analog conversion module, the USB charging module is connected to the charging switch module, and the power supply module, the power detection module and the charging switch module are all connected to the first battery.

7. A non-invasive chronic non-bacterial prostatitis rat modeling device according to claim 6, characterized in that: The rat prostate multimodal stimulator includes a cover plate, an enclosure plate and a base plate, a display screen and operation buttons are fixed on the cover plate, an infrared radiation slot is opened on the base plate, an infrared radiation plate is inserted in the infrared radiation slot, a plurality of infrared radiation lamp beads are fixed on the infrared radiation plate, a second control circuit board, a second battery and a vibration control relay are fixed on the base plate, a wire is led out from the bottom of the base plate, a vibration rod is connected to the vibration control relay through the wire, and the vibration control relay, the battery and the infrared radiation lamp beads are all connected to the second control circuit board.

8. A non-invasive chronic non-bacterial prostatitis rat modeling device according to claim 7, characterized in that: A processing chip, a power module, a constant current source drive module and a digital-to-analog conversion module are fixed on the second control circuit board. The power module, the constant current source drive module and the digital-to-analog conversion module are all connected to the processing chip, the vibration control relay is connected to the digital-to-analog conversion module, the infrared radiation lamp bead is connected to the constant current source drive module, and the second battery is connected to the power module.

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