High-absorption composite calcium and preparation method thereof

Abstract

The invention relates to the technical field of nutritional supplements, in particular to high-absorption compound calcium which comprises the following components: calcium, ferrous glycinate, zinc glycinate, magnesium, vitamin D3, vitamin K2, casein phosphopeptides and linolenic acid type grease. The invention relates to a calcium supplement, which comprises, by weight, 28%-39% of calcium, 0.5%-0.9% of ferrous glycinate, 0.6%-0.7% of zinc glycinate, 6%-9% of magnesium, 0.9%-1.1% of vitamin D3, 0.6%-0.9% of vitamin K2, 0.8%-1.3% of casein phosphopeptides, and 25%-41% of linolenic acid grease, and has the following beneficial effects: through a tricalcium-in-one technology, the total absorption rate of calcium is greatly improved. The common side effects of flatulence, constipation, black stool and the like of the traditional calcium supplement are avoided.

Description

Technical Field

[0001] The present invention relates to a highly absorbable compound calcium and a preparation method thereof, belonging to the technical field of nutritional supplements. Background Art

[0002] The demand for calcium and various nutrient elements by pregnant and lactating women increases significantly. Calcium is a key element for fetal bone development and the mother to maintain her own bone density. Iron can prevent anemia during pregnancy, and zinc helps enhance the immunity of pregnant women. However, there are many problems with traditional calcium supplements. For example, the absorption rate of some calcium sources is low, making it difficult to meet the needs of mothers and infants; some calcium supplements can stimulate the gastrointestinal tract, causing side effects such as flatulence, constipation, and black stools, bringing discomfort to pregnant women; and a single calcium supplement cannot meet the needs of pregnant women for multiple nutrient elements at the same time. Existing nutritional supplements also have deficiencies in terms of ingredient combination, dosage form design, etc., and cannot well adapt to the special physiological state of pregnant women. There is an urgent need for a more scientific and effective compound calcium product. Summary of the Invention

[0003] Aiming at the deficiencies of the existing technology, the purpose of the present invention is to provide a highly absorbable compound calcium and a preparation method thereof to solve the problems mentioned in the above background art.

[0004] To achieve the above purpose, the present invention is realized through the following technical solutions: A highly absorbable compound calcium includes the following components: calcium, ferrous glycinate, zinc glycinate, magnesium, vitamin D3, vitamin K2, casein phosphopeptide, linolenic acid type oil. By weight: 28% - 39% calcium, 0.5% - 0.9% ferrous glycinate, 0.6% - 0.7% zinc glycinate, 6% - 9% magnesium, 0.9% - 1.1% vitamin D3, 0.6% - 0.9% vitamin K2, 0.8% - 1.3% casein phosphopeptide, 25% - 41% linolenic acid type oil.

[0005] Specifically, the calcium includes chelated calcium, seaweed calcium, and milk calcium. The seaweed calcium is seaweed calcium after being pulverized. The milk calcium is subjected to sterilization treatment during the extraction process. The mass ratio of chelated calcium, seaweed calcium, and milk calcium is 3:5:2.

[0006] Specifically, the vitamin K2 is of the MK-7 type.

[0007] A preparation method of a highly absorbable compound calcium includes the following steps: Step 1: Raw material selection and processing: Strictly screen raw materials of chelated calcium, seaweed calcium, milk calcium, ferrous glycinate, zinc glycinate, magnesium, vitamin D3, vitamin K2, casein phosphopeptide, and linolenic acid-type oil. Conduct purity detection and pretreatment on the raw materials to ensure they meet production requirements. Crush the seaweed calcium to make its particle size reach a specific standard for subsequent mixing and absorption; perform sterilization treatment on the milk calcium to ensure the safety of the product; Step 2: Mixing and stirring: According to the precise formula ratio, sequentially put solid raw materials of chelated calcium, seaweed calcium, milk calcium, ferrous glycinate, zinc glycinate, and magnesium into a high-efficiency mixer, and conduct pre-mixing at a specific stirring speed and time to ensure the preliminary uniform dispersion of various solid components. Then, add nutritional components of vitamin D3, vitamin K2, and casein phosphopeptide in proportion and continue stirring and mixing; Step 3: Oil emulsification: Heat the linolenic acid-type oil to an appropriate temperature to make it have good fluidity, then add an appropriate amount of emulsifier and conduct emulsification treatment in a high-speed emulsification device to form a uniform emulsion. Strictly control the temperature and stirring speed during the emulsification process to ensure the stability and fineness of the emulsion; Step 4: Mixing and homogenization: Mix the pre-mixed solid components with the emulsified oil emulsion, and put them into a homogenizer for homogenization treatment again. The homogenizer fully disperses and refines the mixture through high pressure, so that various components are evenly distributed in the system to form a stable liquid mixture; Step 5: Soft capsule filling: Mix gelatin, glycerin, and purified water in a certain proportion, heat and dissolve them to make the soft capsule shell material. Fill the above liquid mixture into the soft capsule shell through a quantitative filling device. Strictly control the filling amount and filling speed during the filling process to ensure that the content of each soft capsule is consistent; Step 6: Shaping and drying: The filled soft capsules are subjected to shaping treatment through a shaping device to make them have a unified appearance shape, and then enter the drying workshop to be dried under specific temperature and humidity conditions to remove excess moisture on the surface and inside of the soft capsules, improving the stability and shelf life of the product; Step 7: Quality control: During the production process, conduct strict quality inspections on each batch of products. The inspection items include appearance, size, content of the contents, and microbial indicators to ensure that the contents of calcium, iron, zinc, and vitamin nutritional components in the product meet the product specification requirements, and at the same time ensure the safety and stability of the product.

[0008] Specifically, the seaweed calcium is crushed to 200 - 300 mesh, and the chelated calcium, seaweed calcium, milk calcium, ferrous glycinate, zinc glycinate, and magnesium solid raw materials are sequentially put into a high - efficiency mixer, and stirred at a speed of 200 - 300 r / min for 15 - 20 min for pre - mixing. Then, vitamin D3, vitamin K2, and casein phosphopeptide nutritional components are added, and stirring continues at a speed of 150 - 200 r / min for 10 - 15 min; then oil emulsification is carried out. The linolenic acid - type oil is heated to 60 - 70 °C, an emulsifier accounting for 3% - 5% of the oil mass is added, and emulsification is carried out at a speed of 5000 - 6000 r / min in a high - speed emulsification device for 15 - 20 min; after that, mixing and homogenization are carried out. The pre - mixed solid components are mixed with the emulsified oil emulsion, put into a homogenizer, and homogenized at a pressure of 20 - 30 MPa for 10 - 15 min; finally, soft capsule filling and shaping and drying are carried out. Gelatin, glycerol, and purified water are mixed according to a mass ratio of 10:4:6, heated to 70 - 80 °C and dissolved to make a soft capsule shell material. The above liquid mixture is filled into the soft capsule shell at a rate of 500 - 600 mg per capsule through a quantitative filling device. The filled soft capsules are shaped for 20 - 30 min under the conditions of 30 - 35 °C and a relative humidity of 40% - 50% by a shaping device, and then dried for 8 - 12 h in an environment with a temperature of 25 - 30 °C and a humidity of 20% - 30%.

[0009] Specifically, in the mixing and stirring step, there are multiple layers of stirring paddles in the high - efficiency mixer. The stirring paddles include radial stirring paddles and axial stirring paddles. The radial stirring paddles are used to fully mix the materials in the horizontal direction, and the axial stirring paddles are used to make the materials circulate vertically. This design of the stirring paddles can improve the mixing efficiency and ensure that various raw materials are more evenly distributed during the mixing process. The radial stirring paddles can disperse and stir the materials in the horizontal direction, avoiding local accumulation of raw materials in the mixer; the axial stirring paddles promote the vertical circulation of the materials, enabling the materials at different levels to come into full contact and mix.

[0010] Specifically, in the oil emulsification step, the emulsifier is a compound of lecithin and Tween - 80, and the mass ratio of lecithin to Tween - 80 is 2:3. The compound of lecithin and Tween - 80 as an emulsifier has a good emulsification effect. Lecithin has hydrophilic and lipophilic groups, which can reduce the surface tension at the oil - water interface and make the oil easier to disperse in the water phase; Tween - 80 has good emulsification, dispersion, and solubilization properties. When the two are compounded in a specific ratio, a synergistic effect can be produced, enhancing the emulsification ability of the linolenic acid - type oil, making the oil emulsion more stable and the particles finer. The stable oil emulsion helps to improve the stability and taste of the product, and is beneficial to the absorption of nutritional components in the human body, improving the quality of the product.

[0011] Specifically, in the shaping and drying step, the drying process is divided into two stages. In the first stage, the drying temperature is 30 - 35°C, the humidity is 30% - 40%, and the drying time is 4 - 6 hours. In the second stage, the drying temperature is 25 - 30°C, the humidity is 20% - 30%, and the drying time is 4 - 6 hours. Moreover, the temperature in the first stage is higher than that in the second stage, and the humidity in the first stage is higher than that in the second stage. This way of segmented drying can better control the drying process of soft capsules. In the first stage, the higher temperature and humidity can quickly remove most of the water on the surface of the soft capsules, improving the drying efficiency. In the second stage, reducing the temperature and humidity can prevent the surface of the soft capsules from cracking due to excessive drying, and at the same time further remove the residual water inside, making the soft capsules reach an appropriate water content, ensuring their stability and flexibility. Through segmented drying, the qualified rate of the product is improved, and the quality and appearance of the product are guaranteed.

[0012] Specifically, in the quality control step, quality inspection is carried out on each batch of products. The inspection items include appearance, size, content, and microbial indicators. Among them, the atomic absorption spectrometry is used to detect the contents of calcium, iron, zinc, and magnesium, the high performance liquid chromatography is used to detect the contents of vitamin D3, vitamin K2, and casein phosphopeptide, and the standard method of microbial detection is used to detect the microbial indicators. When the calcium content is within ±5% of the standard value, the iron content is within ±5% of the standard value, the zinc content is within ±5% of the standard value, the magnesium content is within ±5% of the standard value, the vitamin D3 content is within ±10% of the standard value, the vitamin K2 content is within ±10% of the standard value, the casein phosphopeptide content is within ±10% of the standard value, and the microbial indicators meet the relevant regulations of the "National Food Safety Standard Health Food" (GB16740), it is determined that this batch of products is qualified.

[0013] The beneficial effects of the present invention: Unique calcium source combination: Innovatively, three calcium sources, chelated calcium, seaweed calcium, and milk calcium, are adopted. Chelated calcium exists in a small molecule structure, with good stability and solubility, and can be absorbed by the human body without consuming gastric acid, effectively reducing the irritation to the gastrointestinal tract. Seaweed calcium, as a natural plant calcium source, has a unique honeycomb structure, which is more easily soluble and absorbable. Milk calcium is extracted from cow's milk, and the calcium - phosphorus ratio is the golden ratio of 2:1, being rich in nutrition and easy to absorb. Through the three - calcium combination technology, the overall absorption rate of calcium is greatly improved.

[0014] Gentle and non - irritating formula: The calcium sources are carefully selected, with gentle properties, avoiding common side effects such as flatulence, constipation, and black stools of traditional calcium supplements, and are especially suitable for pregnant women with acid reflux in the early pregnancy and intestinal compression in the late pregnancy.

[0015] Precise calcium deposition formula: Added with highly active MK-7 type vitamin K2, it has high bioavailability and can accurately guide calcium deposition into the bones, simultaneously increasing the bone density of pregnant mothers and promoting fetal bone development.

[0016] Synergistic nutritional combination: scientific compound of vitamin D3, magnesium and casein phosphopeptide (CPP). Vitamin D3 promotes intestinal calcium absorption and renal reabsorption, which can increase calcium absorption rate by 2-3 times; magnesium regulates calcium transport and bone deposition in the body, which helps pregnant women to efficiently supplement calcium while also having a positive effect on fetal development; casein phosphopeptide can prevent calcium precipitation and gently promote calcium ion transport. Multiple ingredients work synergistically to further improve the calcium supplement effect.

[0017] Multiple nutritional supplements: Additional ferrous glycine and zinc glycine are added. Ferrous glycine can effectively improve anemia during pregnancy without causing constipation or black stools; zinc glycine can effectively improve the immunity of pregnant women and protect the health of mothers and babies in all aspects.

[0018] Optimize dosage form design: Liquid calcium soft capsule dosage form is selected, which is easier to absorb and easier to swallow than traditional tablets, and can be easily taken by women during morning sickness. DETAILED DESCRIPTION

[0019] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further explained below in conjunction with specific implementation methods.

[0020] The invention provides a technical solution: a highly absorbable composite calcium, comprising the following ingredients: calcium, ferrous glycine, zinc glycine, magnesium, vitamin D3, vitamin K2, casein phosphopeptide, and linolenic acid type oil, wherein the ingredients are calculated by weight: 28%-39% calcium, 0.5%-0.9% ferrous glycine, 0.6%-0.7% zinc glycine, 6%-9% magnesium, 0.9%-1.1% vitamin D3, 0.6%-0.9% vitamin K2, 0.8%-1.3% casein phosphopeptide, and 25%-41% linolenic acid type oil.

[0021] The calcium includes chelated calcium, seaweed calcium and milk calcium. The seaweed calcium is crushed seaweed calcium, and the milk calcium is sterilized during the extraction process. The mass ratio of the chelated calcium, seaweed calcium and milk calcium is 3:5:2.

[0022] The vitamin K2 is of MK-7 type.

[0023] A method for preparing highly absorbable composite calcium comprises the following steps: Step 1: Raw material selection and processing: Strictly screen chelated calcium, seaweed calcium, milk calcium, ferrous glycinate, zinc glycinate, magnesium, vitamin D3, vitamin K2, casein phosphopeptide, and linolenic acid type oil raw materials that meet quality standards. Conduct purity testing and pretreatment on the raw materials to ensure they meet production requirements. Crush the seaweed calcium to make its particle size reach a specific standard for subsequent mixing and absorption; sterilize the milk calcium to ensure the safety of the product; Step 2: Mixing and stirring: According to the precise formula ratio, sequentially put the solid raw materials of chelated calcium, seaweed calcium, milk calcium, ferrous glycinate, zinc glycinate, and magnesium into a high-efficiency mixer, and perform premixing at a specific stirring speed and time to ensure that various solid components are initially evenly dispersed. Then, add the nutritional components of vitamin D3, vitamin K2, and casein phosphopeptide in proportion and continue stirring and mixing; Step 3: Oil emulsification: Heat the linolenic acid type oil to an appropriate temperature to make it have good fluidity, then add an appropriate amount of emulsifier and perform emulsification treatment in a high-speed emulsification device to form a uniform emulsion. Strictly control the temperature and stirring speed during the emulsification process to ensure the stability and fineness of the emulsion; Step 4: Mixing and homogenization: Mix the premixed solid components with the emulsified oil emulsion, and put them into a homogenizer for homogenization treatment again. The homogenizer fully disperses and refines the mixture through high pressure, so that various components are evenly distributed in the system to form a stable liquid mixture; Step 5: Soft capsule filling: Mix gelatin, glycerol, and purified water in a certain proportion, heat and dissolve them to make the soft capsule shell material, and accurately fill the above liquid mixture into the soft capsule shell through a quantitative filling device. Strictly control the filling amount and filling speed during the filling process to ensure that the content of each soft capsule is consistent; Step 6: Shaping and drying: The filled soft capsules are subjected to shaping treatment through a shaping device to make them have a unified appearance shape, and then enter the drying workshop and are dried under specific temperature and humidity conditions to remove the excess moisture on the surface and inside of the soft capsules, improving the stability and shelf life of the product; Step 7: Quality control: During the production process, conduct strict quality inspections on each batch of products. The inspection items include appearance, size, content of the contents, and microbial indicators to ensure that the contents of calcium, iron, zinc, and vitamin nutritional components in the product meet the product specification requirements, and at the same time ensure the safety and stability of the product.

[0024] The seaweed calcium is crushed to 200 - 300 mesh, and the chelated calcium, seaweed calcium, milk calcium, ferrous glycinate, zinc glycinate, and magnesium solid raw materials are sequentially put into a high - efficiency mixer and stirred at a speed of 200 - 300 r / min for 15 - 20 min for pre - mixing. Then, vitamin D3, vitamin K2, and casein phosphopeptide nutritional components are added, and stirring continues at a speed of 150 - 200 r / min for 10 - 15 min; then, oil emulsification is carried out. The linolenic acid - type oil is heated to 60 - 70 °C, an emulsifier accounting for 3% - 5% of the oil mass is added, and emulsification is carried out at a speed of 5000 - 6000 r / min for 15 - 20 min in a high - speed emulsification device; after that, mixing and homogenization are carried out. The pre - mixed solid components are mixed with the emulsified oil emulsion, put into a homogenizer, and homogenized at a pressure of 20 - 30 MPa for 10 - 15 min; finally, soft capsule filling and shaping and drying are carried out. Gelatin, glycerol, and purified water are mixed in a mass ratio of 10:4:6, heated to 70 - 80 °C and dissolved to make soft capsule shell materials. The above liquid mixture is filled into soft capsule shells at a rate of 500 - 600 mg per capsule through a quantitative filling device. The filled soft capsules are shaped for 20 - 30 min under the conditions of 30 - 35 °C and a relative humidity of 40% - 50% by a shaping device, and then dried for 8 - 12 h in an environment with a temperature of 25 - 30 °C and a humidity of 20% - 30%.

[0025] In the mixing and stirring step, there are multiple layers of stirring paddles in the high - efficiency mixer. The stirring paddles include radial stirring paddles and axial stirring paddles. The radial stirring paddles are used to fully mix the materials in the horizontal direction, and the axial stirring paddles are used to make the materials circulate vertically. This design of the stirring paddles can improve the mixing efficiency and ensure that various raw materials are more evenly distributed during the mixing process. The radial stirring paddles can disperse and stir the materials in the horizontal direction, avoiding local accumulation of raw materials in the mixer; the axial stirring paddles promote the vertical circulation of the materials, enabling the materials at different levels to come into full contact and mix.

[0026] In the oil emulsification step, the emulsifier is a compound of lecithin and Tween - 80, and the mass ratio of lecithin to Tween - 80 is 2:3. The compound of lecithin and Tween - 80 as an emulsifier has good emulsification effects. Lecithin has hydrophilic and lipophilic groups, which can reduce the surface tension at the oil - water interface and make the oil easier to disperse in the aqueous phase; Tween - 80 has good emulsification, dispersion, and solubilization properties. The two are compounded in a specific ratio, which can produce a synergistic effect, enhance the emulsification ability of linolenic acid - type oil, make the oil emulsion more stable, and the particles more delicate. The stable oil emulsion helps to improve the stability and taste of the product, and is conducive to the absorption of nutritional components in the human body, thus enhancing the quality of the product.

[0027] In the shaping and drying step, the drying process is divided into two stages. In the first stage, the drying temperature is 30 - 35°C, the humidity is 30% - 40%, and the drying time is 4 - 6 hours. In the second stage, the drying temperature is 25 - 30°C, the humidity is 20% - 30%, and the drying time is 4 - 6 hours. Moreover, the temperature in the first stage is higher than that in the second stage, and the humidity in the first stage is higher than that in the second stage. This way of segmented drying can better control the drying process of soft capsules. In the first stage, the higher temperature and humidity can quickly remove most of the water on the surface of the soft capsules, improving the drying efficiency. In the second stage, reducing the temperature and humidity can prevent the surface of the soft capsules from cracking due to excessive drying, and at the same time further remove the residual water inside, making the soft capsules reach an appropriate water content, ensuring their stability and flexibility. Through segmented drying, the qualified rate of the product is improved, and the quality and appearance of the product are guaranteed.

[0028] In the quality control step, quality inspections are carried out on each batch of products. The inspection items include appearance, size, content of the internal substance, and microbial indicators. Among them, atomic absorption spectrometry is used to detect the contents of calcium, iron, zinc, and magnesium, high performance liquid chromatography is used to detect the contents of vitamin D3, vitamin K2, and casein phosphopeptide, and standard microbial detection methods are used to detect microbial indicators. When the calcium content is within ±5% of the standard value, the iron content is within ±5% of the standard value, the zinc content is within ±5% of the standard value, the magnesium content is within ±5% of the standard value, the vitamin D3 content is within ±10% of the standard value, the vitamin K2 content is within ±10% of the standard value, the casein phosphopeptide content is within ±10% of the standard value, and the microbial indicators comply with the relevant regulations of "National Food Safety Standard Health Food" (GB16740), it is determined that this batch of products is qualified.

[0029] Example 1 A highly absorbable composite calcium, by weight, contains 37% calcium, 7% magnesium, 33% linolenic acid type oil, and the total of ferrous glycinate, zinc glycinate, vitamin D3, vitamin K2, and casein phosphopeptide is 3%. Among them, the calcium is composed of chelated calcium, seaweed calcium, and milk calcium, and the mass ratio is 3:5:2. The seaweed calcium is subjected to a pulverization treatment, and the milk calcium is subjected to a sterilization treatment during the extraction process; the vitamin K2 is of the MK-7 type.

[0030] In this example, ferrous glycinate accounts for 0.6%, zinc glycinate accounts for 0.6%, vitamin D3 accounts for 1%, vitamin K2 accounts for 0.4%, and casein phosphopeptide accounts for 0.4%.

[0031] Preparation method: Raw material selection and processing: Chelated calcium, seaweed calcium, milk calcium, ferrous glycinate, zinc glycinate, magnesium, vitamin D3, vitamin K2 (MK-7 type), casein phosphopeptide, and linolenic acid type oil raw materials that meet the quality standards are strictly screened. The seaweed calcium is crushed to 200 meshes, and the milk calcium is sterilized by high-temperature sterilization method. At the same time, the purity of all raw materials is detected to ensure compliance with production requirements.

[0032] Mixing and stirring: The solid raw materials of chelated calcium, seaweed calcium, milk calcium, ferrous glycinate, zinc glycinate, and magnesium are sequentially put into a high-efficiency mixer and stirred at a speed of 200 r / min for 15 min for pre-mixing. Then, vitamin D3, vitamin K2, and casein phosphopeptide are added, and stirring continues at a speed of 150 r / min for 10 min.

[0033] Oil emulsification: Heat the linolenic acid type oil to 60 °C, add an emulsifier (compounded by lecithin and Tween-80 at a mass ratio of 2:3) accounting for 3% of the oil mass, and emulsify at a speed of 5000 r / min in a high-speed emulsification device for 15 min.

[0034] Mixing and homogenization: Mix the pre-mixed solid components with the emulsified oil emulsion, put them into a homogenizer, and homogenize at a pressure of 20 MPa for 10 min.

[0035] Soft capsule filling: Mix gelatin, glycerol, and purified water according to a mass ratio of 10:4:6, heat to 70 °C and dissolve to make the soft capsule shell material. Fill the above liquid mixture into the soft capsule shell at a rate of 500 mg per capsule through a quantitative filling device.

[0036] Shaping and drying: The filled soft capsules are shaped by a shaping device at 30 °C and a relative humidity of 40% for 20 min, and then dried in an environment with a temperature of 25 °C and a humidity of 20% for 8 h.

[0037] Quality inspection data: Detected by atomic absorption spectrometry, the calcium content is +3% of the standard value, the iron (calculated as ferrous glycinate) content is +2% of the standard value, the zinc (calculated as zinc glycinate) content is +3% of the standard value, and the magnesium content is +2% of the standard value. Detected by high-performance liquid chromatography, the vitamin D3 content is +8% of the standard value, the vitamin K2 content is +7% of the standard value, and the casein phosphopeptide content is +8% of the standard value. The detection results of microbial indicators comply with the relevant regulations of the "National Food Safety Standard Health Food" (GB16740), and this batch of products is judged to be qualified.

[0038] Example 2 A highly absorbable compound calcium, by weight, contains 35% calcium, 8% magnesium, 34% linolenic acid type oil, and the sum of ferrous glycinate, zinc glycinate, vitamin D3, vitamin K2, and casein phosphopeptide is 4%. The calcium consists of chelated calcium, seaweed calcium, and milk calcium, with a mass ratio of 3:5:2. The seaweed calcium is pulverized, and the milk calcium is sterilized during the extraction process; vitamin K2 is of the MK-7 type.

[0039] In this embodiment, ferrous glycinate accounts for 0.7%, zinc glycinate accounts for 0.6%, vitamin D3 accounts for 1.1%, vitamin K2 accounts for 0.6%, and casein phosphopeptide accounts for 1.1%.

[0040] Preparation method: Raw material selection and treatment: Various raw materials meeting the quality standards are strictly screened. The seaweed calcium is pulverized to 250 mesh, the milk calcium is sterilized by the filtration sterilization method, and the purity of the raw materials is detected.

[0041] Mixing and stirring: Chelated calcium, seaweed calcium, milk calcium, ferrous glycinate, zinc glycinate, and magnesium solid raw materials are successively put into a high-efficiency mixer and stirred at a speed of 250 r / min for 18 min for pre-mixing. Then vitamin D3, vitamin K2, and casein phosphopeptide are added, and stirring continues at a speed of 180 r / min for 12 min.

[0042] Oil emulsification: The linolenic acid type oil is heated to 65 °C, and an emulsifier (compounded by lecithin and Tween-80 in a mass ratio of 2:3) accounting for 4% of the oil mass is added, and emulsification is carried out at a speed of 5500 r / min in a high-speed emulsification device for 18 min.

[0043] Mixing and homogenization: The pre-mixed solid components are mixed with the emulsified oil emulsion, put into a homogenizer, and homogenized at a pressure of 25 MPa for 12 min.

[0044] Soft capsule filling: Gelatin, glycerol, and purified water are mixed in a mass ratio of 10:4:6, heated to 75 °C and dissolved to make the soft capsule shell material, and filled into the soft capsule shell at a rate of 550 mg per capsule.

[0045] Sizing and drying: The filled soft capsules are sized at 32 °C and a relative humidity of 45% for 25 min, and then dried in an environment with a temperature of 28 °C and a humidity of 25% for 10 h.

[0046] Quality inspection data: Detected by atomic absorption spectrometry, the calcium content is -2% of the standard value, the iron content is +3% of the standard value, the zinc content is +2% of the standard value, and the magnesium content is +3% of the standard value. Detected by high performance liquid chromatography, the vitamin D3 content is +9% of the standard value, the vitamin K2 content is +8% of the standard value, and the casein phosphopeptide content is +9% of the standard value. The microbiological indicators comply with the relevant provisions of the "National Food Safety Standard Health Food" (GB16740), and this batch of products is qualified.

[0047] Example 3 A highly absorbable compound calcium, by weight, contains 30% calcium, 6% magnesium, 40% linolenic acid type oil, and the total of ferrous glycinate, zinc glycinate, vitamin D3, vitamin K2, and casein phosphopeptide is 3%. Among them, the calcium is composed of chelated calcium, seaweed calcium and milk calcium, and the mass ratio is 3:5:2. The seaweed calcium is pulverized, and the milk calcium is sterilized during the extraction process; the vitamin K2 is of the MK-7 type.

[0048] In this example, ferrous glycinate accounts for 0.5%, zinc glycinate accounts for 0.6%, vitamin D3 accounts for 0.9%, vitamin K2 accounts for 0.6%, and casein phosphopeptide accounts for 0.4%.

[0049] Preparation method: Raw material selection and treatment: Strictly screen the raw materials, pulverize the seaweed calcium to 300 meshes, sterilize the milk calcium (such as using ultraviolet sterilization method), and detect the purity of the raw materials.

[0050] Mixing and stirring: Put the chelated calcium, seaweed calcium, milk calcium, ferrous glycinate, zinc glycinate, and magnesium solid raw materials into a high-efficiency mixer in turn, and stir at a speed of 300 r / min for 20 min for pre-mixing. Then add vitamin D3, vitamin K2, and casein phosphopeptide, and continue to stir at a speed of 200 r / min for 15 min.

[0051] Oil emulsification: Heat the linolenic acid type oil to 70 °C, add an emulsifier accounting for 5% of the oil mass (compounded by lecithin and Tween-80 in a mass ratio of 2:3), and emulsify at a speed of 6000 r / min in a high-speed emulsification device for 20 min.

[0052] Mixing and homogenization: Mix the pre-mixed solid components with the emulsified oil emulsion, put them into a homogenizer, and homogenize at a pressure of 30 MPa for 15 min.

[0053] Soft capsule filling: Mix gelatin, glycerol, and purified water in a mass ratio of 10:4:6, heat to 80 °C to dissolve to make the soft capsule shell material, and fill it into the soft capsule shell at a rate of 600 mg per capsule.

[0054] Sizing and drying: The filled soft capsules are sized for 30 min at 35 °C and a relative humidity of 50%, and then dried for 12 h in an environment with a temperature of 30 °C and a humidity of 30%.

[0055] Quality inspection data: The test results by atomic absorption spectrometry show that the calcium content is -3% of the standard value, the iron content is -2% of the standard value, the zinc content is -1% of the standard value, and the magnesium content is -2% of the standard value. The test by high performance liquid chromatography shows that the vitamin D3 content is -8% of the standard value, the vitamin K2 content is -7% of the standard value, and the casein phosphopeptide content is -8% of the standard value. The microbial indicators meet the relevant provisions of the "National Food Safety Standard for Health Foods" (GB16740), and this batch of products is judged to be qualified.

[0056] Although this specification is described according to the embodiments, not every embodiment only contains an independent technical solution. This narrative way of the specification is only for clarity. Those skilled in the art should regard the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A highly absorbable compound calcium, characterized in that It includes the following ingredients: calcium, ferrous glycine, zinc glycine, magnesium, vitamin D3, vitamin K2, casein phosphopeptide, and linolenic acid type oil, calculated by weight: 28%-39% calcium, 0.5%-0.9% ferrous glycine, 0.6%-0.7% zinc glycine, 6%-9% magnesium, 0.9%-1.1% vitamin D3, 0.6%-0.9% vitamin K2, 0.8%-1.3% casein phosphopeptide, and 25%-41% linolenic acid type oil.

2. A highly absorbable composite calcium according to claim 1, characterized in that: The calcium includes chelated calcium, seaweed calcium and milk calcium. The seaweed calcium is crushed seaweed calcium, and the milk calcium is sterilized during the extraction process. The mass ratio of the chelated calcium, seaweed calcium and milk calcium is 3:5:

2.

3. A highly absorbable composite calcium according to claim 1, characterized in that: The vitamin K2 is of MK-7 type.

4. The method for preparing a highly absorbable composite calcium according to claim 1, characterized in that The steps include: Step 1: Raw material selection and processing: Strictly screen chelated calcium, seaweed calcium, milk calcium, ferrous glycinate, zinc glycinate, magnesium, vitamin D3, vitamin K2, casein phosphopeptide, and linolenic acid oil raw materials that meet quality standards, conduct purity testing and pretreatment of the raw materials to ensure that they meet production requirements, crush the seaweed calcium to make its particle size meet specific standards to facilitate subsequent mixing and absorption; sterilize the milk calcium to ensure product safety; Step 2: Mixing and stirring: According to the precise formula ratio, put the solid raw materials of chelated calcium, seaweed calcium, milk calcium, ferrous glycinate, zinc glycinate, and magnesium into the high-efficiency mixer in turn, and pre-mix them at a specific stirring speed and time to ensure that the various solid ingredients are initially evenly dispersed. Then, add vitamin D3, vitamin K2, and casein phosphopeptide nutrients according to the proportion, and continue to stir and mix; Step 3: Oil emulsification: Heat the linolenic acid oil to an appropriate temperature to make it have good fluidity, then add an appropriate amount of emulsifier and emulsify it in a high-speed emulsifying device to form a uniform emulsion. During the emulsification process, the temperature and stirring speed are strictly controlled to ensure the stability and fineness of the emulsion; Step 4: Mixing and homogenizing: Mix the pre-mixed solid components with the emulsified oil emulsion and put them into the homogenizer for homogenization. The homogenizer fully disperses and refines the mixture through high pressure, so that various components are evenly distributed in the system to form a stable liquid mixture; Step 5: Soft capsule filling: gelatin, glycerin and purified water are mixed in a certain proportion, heated and dissolved to make soft capsule shell material, and the liquid mixture is accurately filled into the soft capsule shell through quantitative filling equipment. The filling amount and filling speed must be strictly controlled during the filling process to ensure that the content of each soft capsule is consistent; Step 6: Shaping and drying: The filled soft capsules are shaped by the shaping equipment to give them a uniform appearance, and then enter the drying workshop to be dried under specific temperature and humidity conditions to remove excess moisture on the surface and inside of the soft capsules, thereby improving the stability and shelf life of the product; Step 7: Quality Control: During the production process, each batch of products is subject to strict quality inspection. The inspection items include appearance, size, content, and microbiological indicators to ensure that the content of calcium, iron, zinc, and vitamin nutrients in the product meets the product specification requirements while ensuring the safety and stability of the product.

5. The method for preparing a highly absorbable composite calcium according to claim 4, characterized in that: The seaweed calcium is crushed to 200-300 meshes, and the solid raw materials of chelated calcium, seaweed calcium, milk calcium, ferrous glycinate, zinc glycinate and magnesium are sequentially put into a high-efficiency mixer, and stirred at a speed of 200-300r / min for 15-20min for pre-mixing, and then vitamin D3, vitamin K2 and casein phosphopeptide nutrients are added, and the stirring is continued at a speed of 150-200r / min for 10-15min; then the oil is emulsified, the linolenic acid oil is heated to 60-70℃, and an emulsifier accounting for 3%-5% of the oil mass is added, and the oil is emulsified at a speed of 5000-6000r / min for 15-20min in a high-speed emulsifying equipment; Then, mixing and homogenization are carried out. The pre-mixed solid components are mixed with the emulsified oil emulsion, put into a homogenizer, and homogenized for 10-15 minutes at a pressure of 20-30MPa; finally, soft capsule filling and shaping and drying are carried out. Gelatin, glycerin, and purified water are mixed in a mass ratio of 10:4:6, heated to 70-80°C to dissolve to form soft capsule shell materials, and the above liquid mixture is filled into the soft capsule shell in an amount of 500-600 mg per capsule through a quantitative filling device. The filled soft capsules are shaped by a shaping device at 30-35°C and a relative humidity of 40%-50% for 20-30 minutes, and then dried at a temperature of 25-30°C and a humidity of 20%-30% for 8-12 hours.

6. The method for preparing a highly absorbable composite calcium according to claim 4, characterized in that: In the mixing and stirring step, a multi-layer stirring paddle is arranged in the high-efficiency mixer, and the stirring paddle includes a radial stirring paddle and an axial stirring paddle. The radial stirring paddle is used to fully mix the material in the horizontal direction, and the axial stirring paddle is used to circulate the material in the vertical direction. The design of this stirring paddle can improve the mixing efficiency and ensure that the various raw materials are more evenly distributed during the mixing process. The radial stirring paddle can disperse and stir the material in the horizontal direction to avoid local accumulation of the raw materials in the mixer; the axial stirring paddle promotes the circulation of the material in the vertical direction, so that the materials at different levels can be fully contacted and mixed.

7. The method for preparing a highly absorbable composite calcium according to claim 4, characterized in that: In the oil emulsification step, the emulsifier is a compound of lecithin and Tween-80, the mass ratio of lecithin to Tween-80 is 2:3, and the compound of lecithin and Tween-80 as an emulsifier has a good emulsification effect. Lecithin has hydrophilic and lipophilic groups, which can reduce the surface tension of the oil-water interface and make the oil more easily dispersed in the water phase; Tween-80 has good emulsifying, dispersing and solubilizing properties. The two are compounded in a specific ratio to produce a synergistic effect, enhance the emulsifying ability of linolenic acid oils, make the oil emulsion more stable, and make the particles finer. Stable oil emulsions help improve the stability and taste of the product, and are beneficial to the absorption of nutrients in the human body, thereby improving the quality of the product.

8. The method for preparing a highly absorbable composite calcium according to claim 4, characterized in that: In the shaping and drying step, the drying process is divided into two stages. In the first stage, the drying temperature is 30-35°C, the humidity is 30%-40%, and the drying time is 4-6h. In the second stage, the drying temperature is 25-30°C, the humidity is 20%-30%, and the drying time is 4-6h. The temperature in the first stage is higher than that in the second stage, and the humidity in the first stage is higher than that in the second stage. This segmented drying method can better control the drying process of the soft capsule. In the first stage, the higher temperature and humidity can quickly remove most of the moisture on the surface of the soft capsule and improve the drying efficiency; in the second stage, the temperature and humidity are lowered to avoid the surface cracking of the soft capsule due to too fast drying, and at the same time, the residual moisture inside is further removed to make the soft capsule reach a suitable moisture content to ensure its stability and flexibility. Through segmented drying, the qualified rate of the product is improved, and the quality and appearance of the product are guaranteed.

9. The method for preparing a highly absorbable composite calcium according to claim 4, characterized in that: In the quality control step, each batch of products is subject to quality inspection, and the inspection items include appearance, size, content, and microbial indicators; atomic absorption spectrometry is used to detect the contents of calcium, iron, zinc, and magnesium, high performance liquid chromatography is used to detect the contents of vitamin D3, vitamin K2, and casein phosphopeptide, and the standard method for microbial detection is used to detect microbial indicators; when the calcium content is within ±5% of the standard value, the iron content is within ±5% of the standard value, the zinc content is within ±5% of the standard value, the magnesium content is within ±5% of the standard value, the vitamin D3 content is within ±10% of the standard value, the vitamin K2 content is within ±10% of the standard value, and the casein phosphopeptide content is within ±10% of the standard value, and the microbial indicators comply with the relevant provisions of the National Food Safety Standard Health Food (GB16740), the batch of products is judged to be qualified.