Traditional Chinese medicine liquid for treating eczema pruritus and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine liquid, in particular to traditional Chinese medicine liquid for treating eczema and pruritus, which is prepared from the following components in parts by weight: 2 parts of rhizoma coptidis, 5 parts of radix scutellariae and 2.7 parts of lucid ganoderma. In the traditional Chinese medicine liquid, the coptis chinensis can clear heat and dry dampness, the scutellaria baicalensis can purge fire and detoxify, the lucid ganoderma can support the healthy energy, the three medicines are synergistic, multiple mechanisms such as anti-inflammation, anti-allergy and immunity regulation are considered, the limitation of a single target of a chemical medicine is broken, the side effects such as skin atrophy and angiotelectasis of hormone medicines are completely avoided, and the traditional Chinese medicine liquid is suitable for long-term safe use; the medicinal materials are crushed to 200 meshes or above, a dynamic decoction tank and high-temperature extraction are matched, the dissolution rate of anti-inflammatory components such as berberine and baicalin in coptis chinensis is remarkably increased, compared with traditional Chinese medicines, the concentration of effective components is increased, pruritus can be relieved within 30 minutes, the effect taking speed of the traditional Chinese medicine liquid is close to that of chemical medicines, and the traditional Chinese medicine liquid is different from chemical antihistamine medicines, does not contain sedative components and is free of toxic and side effects. The liquid soap can be used for special people for driving and operating machinery, and has no irritation to damaged skin.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine liquids, and particularly to a traditional Chinese medicine liquid for treating eczema itching and its preparation method. Background Art

[0002] Traditional Chinese medicine classifies itching into the categories of "itching wind" and "wind itching", and believes that its etiology is mainly caused by the invasion of the four evils of "wind, heat, toxin, and dampness". Among them, "wind" is the leader of all diseases, and it is easy to carry other evils and wander on the muscle surface, causing skin discomfort; the "heat" evil burns body fluids, causing the skin to lose nourishment; the "toxin" evil stagnates blood vessels, exacerbating the inflammatory reaction; the "dampness" evil is sticky and heavy, hindering qi movement and inducing stubborn itching such as eczema.

[0003] Currently, there are many types of currently mainstream chemical antipruritics in use, but hormones are dominant, and non-hormonal ones mostly have effects on the central nervous system; glucocorticoid drugs, such as dexamethasone and hydrocortisone, although they have a rapid onset of action, long-term external use is likely to cause side effects such as skin atrophy and telangiectasia, and may also cause hormone-dependent dermatitis; non-hormonal antihistamines, such as loratadine and cetirizine, relieve itching by blocking H1 receptors, but some drugs can cross the blood-brain barrier, causing central adverse reactions such as drowsiness and dizziness, restricting their application in drivers or high-altitude workers; long-term use of chemical drugs is likely to make pathogens develop drug resistance, resulting in a decline in curative effect, and it is easy to relapse after stopping the drug, while the conventional traditional Chinese medicine antipruritic formula is cumbersome, and the onset time is lower than that of chemical antipruritic methods.

[0004] Therefore, aiming at the problem that although there are many types of the above-mentioned synthetic chemical antipruritics, hormones are dominant, non-hormonal ones mostly have effects on the central nervous system, and the conventional traditional Chinese medicine antipruritic formula is cumbersome and the onset time is lower than that of chemical antipruritic methods, a traditional Chinese medicine liquid for treating eczema itching can be designed. Summary of the Invention

[0005] In order to overcome the problem that although there are many types of synthetic chemical antipruritics, hormones are dominant, non-hormonal ones mostly have effects on the central nervous system, and the conventional traditional Chinese medicine antipruritic formula is cumbersome and the onset time is lower than that of chemical antipruritic methods.

[0006] The technical solution of the present invention is: a traditional Chinese medicine liquid for treating eczema itching, comprising the following components in parts by weight: 2 parts of Coptis chinensis, 5 parts of Scutellaria baicalensis, and 2.7 parts of Ganoderma lucidum.

[0007] Preferably, the Coptis chinensis is selected as high-quality Coptis chinensis with a shape like chicken feet, a surface of yellowish-brown color, a firm texture, an orange-red cortex in the cross-section, and a fresh yellow or orange-yellow xylem.

[0008] Preferably, the Scutellaria baicalensis Georgi used is of high quality with a strip length of ≥15 cm, firm texture, yellow color, and a central decay of less than 5%. The Ganoderma lucidum used is Ganoderma lucidum (Leyss. ex Fr.) Karst. with a semicircular cap, a reddish-brown and shiny cap surface, a thin and flat-truncated edge that is often slightly involuted, and a diameter of ≥10 cm.

[0009] Preferably, it also includes glycerol as an auxiliary material.

[0010] A method for preparing a traditional Chinese medicine liquid for treating eczema itching, which includes the traditional Chinese medicine liquid for treating eczema itching as described above, and the steps are as follows:

[0011] S1: Medicinal material screening and pretreatment

[0012] S11: Using a high-pressure spray cleaning device, with deionized water as the medium, controlling the water flow pressure at 0.2 - 0.3 MPa, cleaning the medicinal materials 360° without dead angles to remove surface sediment, impurities, and microorganisms. After cleaning, lay the medicinal materials flat in a vacuum low-temperature drying oven and dry them at 40 - 50 °C and -0.08 MPa until the water content ≤8%, maintaining the original color and effective components of the medicinal materials;

[0013] S12: Using an ultrafine pulverization device, pulverize the dried medicinal materials to more than 200 meshes to increase the surface area of the medicinal materials and improve the extraction rate of effective components. During the pulverization process, control the temperature ≤45 °C to avoid heat loss of effective components. After pulverization, sieve the medicinal materials and store them sealed;

[0014] S2: Mixed water decoction treatment

[0015] S21: Using a high-precision electronic scale, proportion the ingredients according to the weight ratio of 2 parts of Coptis chinensis Franch., 5 parts of Scutellaria baicalensis Georgi, and 2.7 parts of Ganoderma lucidum (Leyss. ex Fr.) Karst., and the total amount of medicinal materials does not exceed 2 / 3 of the volume of the decocting tank;

[0016] S22: Put the above medicinal materials into a multi-functional dynamic decocting tank, add deionized water, soak the medicinal materials for 2 - 3 hours to make the medicinal materials fully absorb water and expand. Set the decocting temperature at 100 - 110 °C and the decocting time at 1.5 - 2.5 hours, and at the same time maintain the stirring speed at 100 - 150 r / min to make the medicinal materials fully contact with water and promote the dissolution of effective components;

[0017] S3: Separation and clarification

[0018] S31: After the decocting is completed, immediately use a plate and frame filter press equipped with a 100 - 200 mesh filter cloth for rough filtration. The filter cloth needs to be treated by high-temperature sterilization, and the water content of the medicinal residues ≤15%;

[0019] S32: Transfer the rough filtrate to a high-speed centrifuge and centrifuge it at a speed of 3000 - 5000 rpm for 15 - 20 minutes to separate impurity particles with a particle size ≥0.5 μm. After centrifugation, the clarity of the medicinal liquid ≥90 NTU;

[0020] S33: Add 0.2 - 0.5% chitosan flocculant with a molecular weight of 10 - 50 kDa to the centrifugate, stir for 20 minutes at a stirring speed of 150 rpm, let stand for 2 - 3 hours to completely precipitate the suspended matter, and perform terminal filtration using a 0.45 μm polyethersulfone filter membrane. The microbial load of the liquid medicine ≤ 10 CFU / mL;

[0021] S4: Preparation forming

[0022] S41: Add appropriate amounts of sweeteners, preservatives, and stabilizers to the clarified traditional Chinese medicine liquid according to actual needs to improve the taste of the liquid medicine, extend the shelf life, and enhance stability;

[0023] S42: Fill in a D - class clean environment using a fully automatic filling machine. The temperature of the liquid medicine is controlled at 60 - 70°C. The medicinal glass bottles or PET plastic bottles are sterilized at high temperature. The sealing uses hot melt adhesive or aluminum foil induction sealing technology. The sealing tightness is tested by negative pressure, and its leakage rate ≤ 0.5%.

[0024] Preferably, in step S22, the amount of deionized water added to the multi - functional dynamic decocting tank is 8 - 12 times the total weight of the medicinal materials.

[0025] Preferably, in S33, the addition amount of chitosan flocculant is 0.1% - 0.3% of the volume of the filtrate after centrifugation.

[0026] Preferably, the sweetener in S41 is specifically 1.0 - 2.0% honey or 0.03 - 0.05% stevioside.

[0027] Preferably, the preservative in S41 is specifically 0.1 - 0.2% potassium sorbate.

[0028] Preferably, the stabilizer in S41 is specifically 0.05 - 0.1% xanthan gum.

[0029] The beneficial effects of the present invention: In this traditional Chinese medicine liquid, Coptis chinensis can clear heat and dry dampness, Scutellaria baicalensis can purge fire and detoxify, and Ganoderma lucidum can strengthen the healthy qi and consolidate the root. The three herbs work synergistically, taking into account multiple mechanisms such as anti - inflammation, anti - allergy, and immune regulation, breaking through the limitation of a single target of chemical drugs, and completely avoiding side effects such as skin atrophy and telangiectasia of hormonal drugs, being suitable for long - term and safe use; The medicinal materials are pulverized to over 200 meshes, combined with a dynamic decocting tank and high - temperature extraction, significantly improving the dissolution rate of anti - inflammatory components such as berberine in Coptis chinensis and baicalin in Scutellaria baicalensis. Compared with traditional Chinese medicine, the concentration of active ingredients is increased, and itching can be relieved within 30 minutes, approaching the onset speed of chemical drugs. Different from chemical anti - histamines, this traditional Chinese medicine liquid does not contain sedative ingredients, has no risks such as drowsiness and decreased attention, can be used by special populations such as those driving and operating machinery, is non - irritating to damaged skin, does not require later decocting, and can be used immediately after opening the bottle, being suitable for fast - paced life scenarios. Detailed Implementation Modes

[0030] The present invention will be further described below in conjunction with embodiments.

[0031] Embodiment 1

[0032] The present invention provides an embodiment: a traditional Chinese medicine liquid for treating eczema itching, comprising the following components in parts by weight: 2 parts of Coptis chinensis, 5 parts of Scutellaria baicalensis, 2.7 parts of Ganoderma lucidum. The Coptis chinensis selected is of high quality with a shape like chicken feet, a surface yellowish-brown color, a firm texture, an orange-red cortex in the cross-section, and a fresh yellow or orange-yellow xylem. The Scutellaria baicalensis selected is of high quality with a length of ≥15 cm, a firm texture, a yellow color, and a central decay of less than 5%. The Ganoderma lucidum selected is Ganoderma lucidum with a semicircular pileus, a shiny reddish-brown pileus surface, a thin and flat edge that is often slightly involuted, and a diameter of ≥10 cm. It also includes glycerol as an auxiliary material.

[0033] The preparation method of the traditional Chinese medicine liquid for treating eczema itching includes the traditional Chinese medicine liquid for treating eczema itching as described above, and its steps are as follows:

[0034] S1: Medicinal material screening and pretreatment

[0035] S11: Using a high-pressure spray cleaning device, with deionized water as the medium, controlling the water flow pressure at 0.2 - 0.3 MPa, cleaning the medicinal materials 360° without dead angles to remove surface sediment, impurities and microorganisms. After cleaning, lay the medicinal materials flat in a vacuum low-temperature drying oven and dry them at 40 - 50°C and -0.08 MPa until the water content ≤8%, maintaining the original color and effective components of the medicinal materials;

[0036] S12: Using an ultrafine pulverization device, pulverize the dried medicinal materials to more than 200 meshes to increase the surface area of the medicinal materials and improve the extraction rate of effective components. During the pulverization process, control the temperature ≤45°C to avoid heat loss of effective components. After pulverization, sieve the medicinal materials and store them sealed;

[0037] S2: Mixing and decocting with water treatment

[0038] S21: Using a high-precision electronic scale, proportion the ingredients according to the weight ratio of 2 parts of Coptis chinensis, 5 parts of Scutellaria baicalensis, and 2.7 parts of Ganoderma lucidum, and the total amount of medicinal materials does not exceed 2 / 3 of the volume of the decocting tank;

[0039] S22: Put the above medicinal materials into a multi-functional dynamic decocting tank, add deionized water, soak the medicinal materials for 2 - 3 hours to make the medicinal materials fully absorb water and expand. Set the decocting temperature at 100 - 110°C and the decocting time at 1.5 - 2.5 hours, and at the same time maintain the stirring speed at 100 - 150 r / min to make the medicinal materials fully contact with water and promote the dissolution of effective components. The amount of deionized water added to the multi-functional dynamic decocting tank is 8 - 12 times the total weight of the medicinal materials;

[0040] S3: Separation and clarification

[0041] S31: After the decocting is completed, immediately conduct rough filtration using a plate and frame filter press equipped with a filter cloth of 100 - 200 mesh. The filter cloth needs to be treated with high-temperature sterilization, and the moisture content of the medicinal residues is ≤15%;

[0042] S32: Transfer the rough filtrate to a high-speed centrifuge and centrifuge at a speed of 3000 - 5000 rpm for 15 - 20 minutes to separate impurity particles with a particle size ≥0.5 μm. After centrifugation, the clarity of the medicinal liquid is ≥90 NTU;

[0043] S33: Add 0.2 - 0.5% chitosan flocculant with a molecular weight of 10 - 50 kDa to the centrifuged liquid, stir for 20 minutes at a stirring speed of 150 rpm, let it stand for 2 - 3 hours to completely precipitate the suspended matter, and conduct terminal filtration using a 0.45 μm polyethersulfone filter membrane. The microbial load of the medicinal liquid is ≤10 CFU / mL, and the addition amount of chitosan flocculant is 0.1% - 0.3% of the volume of the filtrate after centrifugation;

[0044] S4: Preparation of the preparation

[0045] S41: Add appropriate amounts of sweeteners, preservatives, and stabilizers to the clarified traditional Chinese medicine liquid according to actual needs to improve the taste of the liquid, extend the shelf life, and improve stability. The sweetener specifically uses 0.03 - 0.05% stevioside; the preservative specifically uses 0.1 - 0.2% potassium sorbate; the stabilizer specifically uses 0.05 - 0.1% xanthan gum;

[0046] S42: Use a fully automatic filling machine to fill in a D - level clean environment. The temperature of the medicinal liquid is controlled at 60 - 70°C. The medicinal glass bottles or PET plastic bottles are treated with high-temperature sterilization, and the sealing uses hot melt adhesive or aluminum foil induction sealing technology. The sealing tightness is tested by negative pressure, and its leakage rate is ≤0.5%.

[0047] Example 2

[0048] The present invention provides an example: A traditional Chinese medicine liquid for treating eczema itching, comprising the following components in parts by weight: 2 parts of Coptis chinensis, 5 parts of Scutellaria baicalensis, 2.7 parts of Ganoderma lucidum. The Coptis chinensis is selected as high-quality Coptis chinensis with a shape like chicken feet, a surface of yellowish brown, a firm texture, an orange - red cortex in the cross - section, and a fresh yellow or orange - yellow xylem. The Scutellaria baicalensis is selected as high-quality Scutellaria baicalensis with a length ≥15 cm, a firm texture, a yellow color, and a central decay less than 5%. The Ganoderma lucidum is selected as Ganoderma lucidum with a semicircular pileus, a shiny reddish - brown pileus surface, a thin and flat - cut edge that is often slightly involuted, and a diameter ≥10 cm. It also includes glycerol as an auxiliary material.

[0049] The preparation method of the traditional Chinese medicine liquid for treating eczema itching, which includes the traditional Chinese medicine liquid for treating eczema itching as described above, and its steps are as follows:

[0050] S1: Medicinal material screening and pretreatment

[0051] S11: Use high-pressure spray cleaning equipment, deionized water as the medium, control the water flow pressure at 0.2-0.3MPa, and clean the medicinal materials 360° without dead angles to remove surface sand, impurities and microorganisms. After cleaning, spread the medicinal materials in a vacuum low-temperature drying oven and dry them at 40-50℃ and -0.08MPa to a moisture content of ≤8%, so as to maintain the original color and effective ingredients of the medicinal materials;

[0052] S12: Use ultrafine grinding equipment to grind the dried medicinal materials to more than 200 meshes to increase the surface area of ​​the medicinal materials and improve the extraction rate of effective ingredients. The temperature during the grinding process is controlled at ≤45°C to avoid heat loss of effective ingredients. After grinding, the medicinal materials are sieved and sealed for storage;

[0053] S2: Mixed decoction

[0054] S21: Use a high-precision electronic scale to prepare the ingredients according to the weight ratio of 2 parts of Coptis chinensis, 5 parts of Scutellaria baicalensis, and 2.7 parts of Ganoderma lucidum. The total amount of medicinal materials should not exceed 2 / 3 of the volume of the decoction pot;

[0055] S22: Put the above medicinal materials into a multifunctional dynamic decoction pot, add deionized water, soak the medicinal materials for 2-3 hours, so that the medicinal materials can fully absorb water and swell, set the decoction temperature to 100-110°C, the decoction time to 1.5-2.5 hours, and keep the stirring speed at 100-150r / min, so that the medicinal materials are fully in contact with water to promote the dissolution of effective ingredients. The amount of deionized water added to the multifunctional dynamic decoction pot is 8-12 times the total weight of the medicinal materials;

[0056] S3: Separation and clarification

[0057] S31: After the decoction is completed, the dregs are immediately coarsely filtered using a plate and frame filter press equipped with a 100-200 mesh filter cloth. The filter cloth needs to be sterilized at high temperature, and the moisture content of the dregs is ≤15%;

[0058] S32: The crude filtrate is transferred to a high-speed centrifuge and centrifuged at 3000-5000 rpm for 15-20 minutes to separate impurity particles with a particle size of ≥0.5 μm. The clarity of the drug solution after centrifugation is ≥90 NTU;

[0059] S33: adding 0.2-0.5% chitosan flocculant with a molecular weight of 10-50 kDa to the centrifuge, stirring for 20 minutes at a stirring speed of 150 rpm, standing for 2-3 hours to allow the suspended matter to completely precipitate, using a 0.45 μm polyethersulfone filter membrane for terminal filtration, the microbial load of the liquid is ≤10 CFU / mL, and the amount of chitosan flocculant added is 0.1%-0.3% of the volume of the filtrate after centrifugation;

[0060] S4: Formulation

[0061] Filling is carried out using a fully automatic filling machine in a Class D clean environment. The temperature of the liquid medicine is controlled at 60 - 70 °C. Medicinal glass bottles or PET plastic bottles are subjected to high-temperature sterilization treatment. The sealing uses hot melt adhesive or aluminum foil induction sealing technology. The tightness of the seal is tested by negative pressure, and its leakage rate ≤ 0.5%.

[0062] Experimental Examples

[0063] 100 patients with eczema itching were invited. The chemical drugs in Examples 1 and 2 and the traditional Chinese medicine in Example 4 were divided into four groups. Then, the 100 patients were evenly assigned to Examples 1 - 4 according to age, gender, and disease severity. Examples 1 and 2 were administered twice a day for a 4-week course. Experimental Example 3 used mometasone furoate cream, once a day for a 4-week course. Example 4 used a decoction of traditional Chinese medicine, twice a day for a 4-week course. The comparative data results of the itching degree score (VAS) are as follows;

[0064]

[0065] The comparative data results of the change rate of the skin lesion area are as follows;

[0066]

[0067] The comparative data results of safety are as follows;

[0068]

Claims

1. A traditional Chinese medicine liquid for treating eczema itching, characterized in that, It comprises the following components in parts by weight: 2 parts of Coptis chinensis, 5 parts of Scutellaria baicalensis, and 2.7 parts of Ganoderma lucidum.

2. The traditional Chinese medicine liquid for treating eczema itching according to claim 1, wherein: The Coptis chinensis selected is high-quality Coptis chinensis in the shape of chicken feet, with a yellowish-brown surface, firm texture, an orange-red cortex on the cross-section, and a bright yellow or orange-yellow xylem.

3. The Chinese medicinal liquid for treating eczema itching according to claim 1, wherein: The Scutellaria baicalensis selected is high-quality Scutellaria baicalensis with a length of ≥15 cm, firm texture, yellow color, and a central decay of less than 5%. The Ganoderma lucidum selected is Ganoderma lucidum with a semicircular cap, a reddish-brown and shiny cap surface, a thin and flat cut edge that is often slightly involuted, and a diameter of ≥10 cm.

4. The traditional Chinese medicine liquid for treating eczema itching according to claim 1, wherein: It also includes glycerol as an auxiliary material.

5. A method for preparing a traditional Chinese medicine liquid for treating eczema itching, characterized in that It includes the traditional Chinese medicine liquid for treating eczema itching according to claims 1-4, and the steps are as follows: S1: Medicinal material screening and pretreatment S11: Using a high-pressure spray cleaning device, with deionized water as the medium, controlling the water flow pressure at 0.2-0.3 MPa, cleaning the medicinal materials 360° without dead angles to remove surface sediment, impurities, and microorganisms. After cleaning, lay the medicinal materials flat in a vacuum low-temperature drying oven and dry them at 40-50°C and -0.08 MPa until the water content ≤8%, maintaining the original color and effective components of the medicinal materials; S12: Using an ultrafine pulverization device, pulverize the dried medicinal materials to more than 200 meshes to increase the surface area of the medicinal materials and improve the extraction rate of effective components. Control the temperature ≤45°C during the pulverization process to avoid heat loss of effective components. After pulverization, sieve the medicinal materials and store them sealed; S2: Mixed water decoction treatment S21: Using a high-precision electronic scale, proportion the ingredients according to the weight ratio of 2 parts of Coptis chinensis, 5 parts of Scutellaria baicalensis, and 2.7 parts of Ganoderma lucidum, and the total amount of medicinal materials does not exceed 2 / 3 of the volume of the decocting tank; S22: Put the above-mentioned medicinal materials into a multi-functional dynamic decocting tank, add deionized water, soak the medicinal materials for 2-3 hours to make the medicinal materials fully absorb water and expand. Set the decocting temperature at 100-110°C and the decocting time at 1.5-2.5 hours, and at the same time maintain the stirring speed at 100-150 r / min to make the medicinal materials fully contact with water and promote the dissolution of effective components; S3: Separation and clarification S31: After the decoction is completed, immediately use a plate and frame filter press equipped with a 100-200 mesh filter cloth for rough filtration. The filter cloth needs to be treated by high-temperature sterilization, and the moisture content of the medicinal residues ≤15%; S32: Transfer the rough filtrate to a high-speed centrifuge and centrifuge at a speed of 3000-5000 rpm for 15-20 minutes to separate impurity particles with a particle size ≥0.5 μm. After centrifugation, the clarity of the medicinal liquid ≥90 NTU; S33: Add 0.2-0.5% chitosan flocculant with a molecular weight of 10-50 kDa to the centrifuged liquid, stir for 20 minutes at a stirring speed of 150 rpm, let it stand for 2-3 hours to make the suspended matter completely precipitate, and use a 0.45 μm polyethersulfone filter membrane for terminal filtration. The microbial load of the medicinal liquid ≤10 CFU / mL; S4: Preparation forming S41: Add appropriate amounts of sweeteners, preservatives, and stabilizers to the clarified traditional Chinese medicine liquid according to actual needs to improve the taste of the medicinal liquid, extend the shelf life, and improve stability; S42: Filling is carried out using a fully automatic filling machine in a Class D clean environment. The temperature of the liquid medicine is controlled at 60 - 70 °C. The medicinal glass bottles or PET plastic bottles are subjected to high-temperature sterilization treatment. The sealing is carried out using hot melt adhesive or aluminum foil induction sealing technology. The tightness of the sealing is tested through negative pressure, and its leakage rate ≤ 0.5%.

6. The preparation method of the traditional Chinese medicine liquid for treating eczema itching according to claim 5, characterized in that: In step S22, the amount of deionized water added to the multi-functional dynamic decocting tank is 8 - 12 times the total weight of the medicinal materials.

7. The preparation method of the traditional Chinese medicine liquid for treating eczema itching according to claim 5, characterized in that: In S33, the addition amount of the chitosan flocculant is 0.1% - 0.3% of the volume of the filtrate after centrifugation.

8. The preparation method of the traditional Chinese medicine liquid for treating eczema itching according to claim 5, characterized in that: The sweetener in S41 specifically uses 1.0 - 2.0% honey or 0.03 - 0.05% stevioside.

9. The preparation method of the traditional Chinese medicine liquid for treating eczema itching according to claim 5, characterized in that: The preservative in S41 specifically uses 0.1 - 0.2% potassium sorbate.

10. The preparation method of the traditional Chinese medicine liquid for treating eczema itching according to claim 5, characterized in that: The stabilizer in S41 specifically uses 0.05 - 0.1% xanthan gum.

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