Emulsifiable paste for treating acne

Abstract

The invention discloses a cream for treating acne. The formula of the cream comprises 0.05% of a pseudo-ginseng root extract, 0.085% of a rhizoma smilacis glabrae extract, 1% of borneol, 1% of camphor, 0.5% of thymol, a willow branch extract (containing 1.5% of salicylic acid), 0.2%-0.4% of carbomer, 0.2%-0.4% of xanthan gum, 1%-3% of liquid paraffin, 1%-2% of caprylic / capric triglyceride, 1%-2% of cetearyl alcohol olivate, 2%-3% of synthetic beeswax, 2%-3% of polydimethylsiloxane and the balance of water. 3%-6% of ethanol; natural components such as the pseudo-ginseng root extract, the rhizoma smilacis glabrae extract, the borneol, the camphor and the thymol are adopted, so that the allergy risk and irritation possibly caused by chemical synthesis components are reduced, and the acne cream is suitable for being used by acne patients with more skin types. A plurality of natural antibacterial components have a synergistic effect and have a relatively strong inhibition effect on pathogenic bacteria such as propionibacterium acnes, and the natural components do not easily induce the pathogenic bacteria to generate drug resistance, so that a good treatment effect can still be kept after long-term use. Various components have anti-inflammatory and repair promoting effects.

Description

Technical Field

[0001] The present invention relates to the field of biomedical technologies, and particularly to a cream for treating acne. Background Art

[0002] Acne, as a common chronic inflammatory skin disease of hair follicles and sebaceous glands, has a relatively high incidence rate globally, especially more prevalent among teenagers. According to statistics, about 85% of teenagers will be troubled by acne during their growth and development stage. Acne not only affects the appearance of patients, but may also have a negative impact on their mental health and reduce the quality of life.

[0003] Currently, there are numerous treatment methods for acne, but each method has certain limitations. In terms of drug treatment, antibiotics are one of the commonly used drugs for treating acne, such as clindamycin, tetracycline, etc. These antibiotics mainly play a role by inhibiting the growth of Propionibacterium acnes. However, long-term use will cause Propionibacterium acnes to develop drug resistance. Relevant research shows that the drug resistance rate of Propionibacterium acnes to tetracycline in some regions has exceeded 30%, which greatly reduces the treatment effect of antibiotics and increases the difficulty of subsequent treatment. In addition, although retinoid drugs have certain effects in regulating follicular keratinization and inhibiting sebaceous gland secretion, these drugs have strong irritation and are likely to cause adverse reactions such as skin dryness, desquamation, and erythema. For patients with sensitive skin, it is difficult to tolerate, thus affecting the compliance of treatment.

[0004] Benzoyl peroxide is also a commonly used drug for treating acne, which has antibacterial and anti-inflammatory effects. However, its irritation is also relatively large, and it may cause discomfort symptoms such as a burning sensation and itching on the skin. Moreover, some patients may be allergic to it, which limits its wide application in clinical practice. In the research on treating acne with natural ingredients, although natural plant extracts have received attention in recent years due to their relatively high safety, many problems still exist. In terms of compound preparations, existing traditional Chinese medicine compounds, such as facial masks containing Salvia miltiorrhiza and Angelica dahurica, can relieve acne symptoms to a certain extent, but there are problems such as unclear active ingredients and low transdermal absorption rate, and often require a long treatment cycle, which is a relatively large time and economic cost for patients. From the overall situation of the existing technology, the current acne treatment means generally have the problem of a single antibacterial mechanism. Therefore, it is extremely urgent to develop an acne treatment drug that can overcome the defects of existing treatment means and has high antibacterial efficiency, low irritation, and good anti-inflammatory and repair synergistic effects. The present invention provides a cream for treating acne. Summary of the Invention

[0005] The object of the present invention is to solve at least one of the technical problems existing in the prior art, and to provide a cream for treating acne, which adopts natural ingredients such as Panax notoginseng root extract, Smilax glabra extract, borneol, camphor, thymol, etc., reducing the allergy risk and irritation that may be brought by chemically synthesized ingredients, and is suitable for acne patients with more skin types.

[0006] Through the synergistic effect of a variety of natural antibacterial ingredients, it has a strong inhibitory effect on pathogenic bacteria such as Propionibacterium acnes, and natural ingredients are not easy to induce pathogenic bacteria to produce drug resistance, and good therapeutic effects can still be maintained after long-term use.

[0007] Through the anti-inflammatory and repair-promoting effects of various ingredients, it can effectively relieve acne inflammation, reduce the formation of erythema and scars after acne healing, not only treat acne, but also improve the skin appearance. It can regulate the secretion of sebaceous glands, reduce oil blockage of pores, prevent the recurrence of acne from the root cause, and maintain the healthy state of the skin.

[0008] The present invention also provides a cream for treating acne as described above, and the formula of the cream includes: Panax notoginseng root extract 0.05%, Smilax glabra extract 0.085%, borneol 1%, camphor 1%, thymol 0.5%, willow branch extract (containing 1.5% salicylic acid), carbomer 0.2% - 0.4%, xanthan gum 0.2% - 0.4%, liquid paraffin 1% - 3%, caprylic / capric triglyceride 1% - 2%, cetearyl olivate 1% - 2%, synthetic beeswax 2% - 3%, polydimethylsiloxane 2% - 3%, ethanol 3% - 6%;

[0009] The preparation of the cream includes the following steps:

[0010] Step 1: Add water, glycerol, p-hydroxyacetophenone, hexylene glycol, carbomer, xanthan gum, allantoin, disodium EDTA into the water phase pot, heat to 80°C - 85°C, and mix and stir well.

[0011] Step 2: Add liquid paraffin, caprylic / capric triglyceride, cetearyl olivate, synthetic beeswax, polydimethylsiloxane into the oil phase pot, heat to 80°C - 85°C, and mix and stir well.

[0012] Step 3: Preheat the main pot to 80°C - 85°C, and pump the raw materials prepared in Step 1 and Step 2 into the main pot respectively, and homogenize and stir to mix evenly.

[0013] Step 4: Stir and cool to 60°C ± 2°C, add propylene glycol and salicylic acid that have been dissolved evenly in advance, and mix and stir well.

[0014] Step 5: Stir and cool to below 45°C, and sequentially add Panax notoginseng root extract, Smilax glabra extract, ethanol, borneol, camphor, thymol, and mix and stir well.

[0015] Step 6: Stir and cool to room temperature, discharge to obtain semi-finished products, and conduct sampling inspection and material transfer;

[0016] Step 7: Fill and package the qualified semi-finished products, and store them in the warehouse after passing the final product inspection.

[0017] According to a cream for treating acne provided by the present invention, the notoginsenoside in the notoginseng root extract can inhibit Propionibacterium acnes, and the minimum inhibitory concentration is 0.5 - 1 mg / mL, and it can also damage the bacterial cell membrane; at the same time, by blocking the NF-κB and MAPK pathways, it reduces the release of pro-inflammatory factors such as IL-6 and TNF-α, and can also inhibit the excessive differentiation of sebaceous gland cells, reduce sebum secretion, and accelerate epidermal cell proliferation, reducing erythema and scars after acne healing.

[0018] According to a cream for treating acne provided by the present invention, the inhibitory zone diameter of the 1% ethanol solution of borneol against Propionibacterium acnes reaches 15 mm, and it can damage the bacterial biofilm structure; by blocking the NF-κB pathway, it reduces the release of IL-1β and TNF-α, and relieves the swelling and redness of inflammatory papules; as a natural transdermal enhancer, it can increase the skin penetration rate of anti-acne components such as salicylic acid and tretinoin by 3 - 5 times, and can also up-regulate epidermal growth factor (EGF) to accelerate the repair of skin after acne breakage.

[0019] According to a cream for treating acne provided by the present invention, the bacteriostatic rate of the 2% cream of camphor against Propionibacterium acnes can reach 75%, and it exerts a bactericidal effect by damaging the lipid structure of the bacterial cell membrane; it has an inhibitory effect on the infections related to folliculitis caused by Malassezia, and the MIC value is 0.5%; by inhibiting the COX-2 and NF-κB pathways, it reduces the release of pro-inflammatory factors such as IL-6 and TNF-α, and relieves acne inflammatory papules; low-concentration camphor (0.5% - 1%) can promote the exfoliation of the epidermal stratum corneum and reduce the formation of follicular plugs; as a fat-soluble component, it can enhance the skin penetration rate of drugs such as salicylic acid and azelaic acid by about 2 - 3 times.

[0020] According to a cream for treating acne provided by the present invention, the MIC of thymol against Propionibacterium acnes is 0.06% - 0.25%, and it can penetrate the biofilm formed by Propionibacterium acnes to enhance the bactericidal effect; by inhibiting the NF-κB pathway, it reduces the release of pro-inflammatory factors (IL-6, TNF-α), scavenges free radicals, and reduces the damage of oxidative stress to the skin; it can inhibit the excessive secretion of sebaceous gland cells and reduce pore blockage.

[0021] According to a cream for treating acne provided by the present invention, salicylic acid cooperates with other components to play antibacterial and keratolytic roles in the cream, which helps to treat acne.

[0022] Compared with the prior art, a cream for treating acne according to the present invention uses natural ingredients such as Panax notoginseng root extract, Smilax glabra extract, borneol, camphor, thymol, etc., reducing the allergy risk and irritation that may be brought by chemically synthesized ingredients, and is suitable for acne patients with more skin types.

[0023] Compared with the prior art, a cream for treating acne according to the present invention has a strong inhibitory effect on pathogenic bacteria such as Propionibacterium acnes through the synergistic action of various natural antibacterial ingredients, and natural ingredients are not likely to induce the production of drug resistance in pathogenic bacteria, and good therapeutic effects can still be maintained after long-term use.

[0024] Compared with the prior art, a cream for treating acne according to the present invention can effectively relieve acne inflammation and reduce the formation of erythema and scars after acne healing through the anti-inflammatory and repair-promoting effects of various ingredients. It can not only treat acne, but also improve the skin appearance. It can regulate the secretion of sebaceous glands, reduce oil blockage of pores, prevent the recurrence of acne from the root cause, and maintain the healthy state of the skin. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] The present invention will be further described below with reference to the drawings and embodiments;

[0026] Figure 1 It is a component ratio diagram of a cream for treating acne according to the present invention;

[0027] Figure 2 It is a comparison diagram of Example 1 and Example 2 of the present invention. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0028] This part will describe the specific embodiments of the present invention in detail. The preferred embodiments of the present invention are shown in the drawings. The role of the drawings is to supplement the description of the text part of the specification, enabling people to intuitively and vividly understand each technical feature and the overall technical solution of the present invention, but it cannot be construed as a limitation on the protection scope of the present invention.

[0029] Example 1. Refer to Figure 1 、 2 Taking 100 g of the cream as an example, the formula composition of a cream for treating acne in an embodiment of the present invention is as follows:

[0030] Active ingredients: 0.05 g of Panax notoginseng root extract, 0.085 g of Smilax glabra extract, 1 g of borneol, 1 g of camphor, 0.5 g of thymol, 1.5 g of salicylic acid.

[0031] Matrix components: Carbomer 0.3 g (taking the median value between 0.2% and 0.4%), Xanthan gum 0.3 g, Liquid paraffin 2 g (taking the median value between 1% and 3%), Caprylic / Capric Triglyceride 1.5 g, Cetearyl Olivate 1.5 g, Synthetic beeswax 2.5 g (taking the median value between 2% and 3%), Polydimethylsiloxane 2.5 g, Ethanol 4 g (taking the median value between 3% and 6%).

[0032] Auxiliary components: Water 50 g, Glycerin 5 g, p-Hydroxyacetophenone 0.5 g, Hexylene glycol 0.5 g, Allantoin 0.2 g, Disodium EDTA 0.1 g, Propylene glycol 3 g.

[0033] The manufacturing process is as follows:

[0034] I. Preparation of the aqueous phase: Add water, glycerin, p-hydroxyacetophenone, and hexylene glycol to the aqueous phase pot, and stir at a low speed of 200 rpm for 5 minutes. Slowly add carbomer and xanthan gum, and homogenize and disperse at a high speed of 1500 rpm for 10 minutes. Add allantoin and disodium EDTA, heat up to 82 °C, and keep stirring for 30 minutes until completely dissolved.

[0035] II. Preparation of the oil phase: Add liquid paraffin, caprylic / capric triglyceride, cetearyl olivate, synthetic beeswax, and polydimethylsiloxane to the oil phase pot. Heat up to 82 °C and stir at a low speed of 150 rpm for 20 minutes until completely melted.

[0036] III. Emulsification and mixing: Preheat the main pot to 82 °C, pump the aqueous phase and the oil phase into the main pot, and homogenize and emulsify at 2000 rpm for 15 minutes.

[0037] IV. Cooling stage: Cool to 60 °C ± 2 °C, add the pre-dissolved salicylic acid-propylene glycol solution, and stir at a medium speed of 300 rpm for 10 minutes. Continue to cool to 40 °C, add the borneol-camphor-thymol ethanol solution and the extracts of Panax notoginseng root and Smilax glabra root, and stir at a low speed of 150 rpm for 20 minutes.

[0038] V. Post-treatment: Cool to room temperature, detect that the pH value is between 5.5 - 6.5, the viscosity is between 5000 - 8000 mPa·s, and the microbial indicators. Dispense into aluminum tubes at 10 g per tube, and label the product information on the outer package.

[0039] VI. Usage method: Twice a day, apply pointwise to the acne area and massage until absorbed.

[0040] Example 2, referring to Figure 1 、 2 For the cream formula composition of an embodiment of the present invention, taking 100 g of cream as an example:

[0041] Active ingredients: 0.05 g of Panax notoginseng root extract, 0.085 g of Smilax glabra extract, 1 g of borneol, 1 g of camphor, 0.5 g of thymol, 1.5 g of salicylic acid.

[0042] Matrix components: 0.2 g of carbomer (taking its lower limit value), 0.4 g of xanthan gum (taking its upper limit value), 1 g of liquid paraffin (taking its lower limit value), 2 g of caprylic / capric triglyceride (taking its upper limit value), 1 g of cetearyl olivate (taking its lower limit value), 3 g of synthetic beeswax (taking its upper limit value), 3 g of polydimethylsiloxane (taking its upper limit value), 6 g of ethanol (taking its upper limit value).

[0043] Auxiliary components: 45 g of water, 5 g of glycerin, 0.5 g of p-hydroxyacetophenone, 0.5 g of hexylene glycol, 0.2 g of allantoin, 0.1 g of disodium EDTA, 3 g of propylene glycol.

[0044] The manufacturing process is as follows:

[0045] I. Preparation of the aqueous phase: Add water, glycerin, p-hydroxyacetophenone, and hexylene glycol to the aqueous phase pot and stir at low speed for 5 minutes. Add carbomer and xanthan gum and homogenize and disperse at high speed for 10 minutes. Add allantoin and disodium EDTA, heat up to 80°C (taking its lower limit value), and stir while maintaining the temperature for 30 minutes.

[0046] II. Preparation of the oil phase: Add liquid paraffin, caprylic / capric triglyceride, cetearyl olivate, synthetic beeswax, and polydimethylsiloxane to the oil phase pot. Heat up to 85°C (taking its upper limit value) and stir at low speed for 20 minutes until completely melted.

[0047] III. Emulsification and mixing: Preheat the main pot to 85°C, pump the aqueous phase and the oil phase into the main pot, and homogenize and emulsify at 2000 rpm for 15 minutes using a homogenizer.

[0048] IV. Cooling stage: Cool to 60°C ± 2°C, add the pre-dissolved salicylic acid-propylene glycol solution, and stir at medium speed for 10 minutes. Continue to cool to 45°C (taking its upper limit value), add the borneol-camphor-thymol ethanol solution, Panax notoginseng root extract, and Smilax glabra extract, and stir at low speed for 20 minutes.

[0049] V. Post-treatment: Cool to room temperature, detect the pH value, viscosity, and microbial indicators. Package into composite film bags, 20 g per bag, and label the product information on the outer package.

[0050] VI. Method of use: Apply thinly to the acne area 3 times a day.

[0051] The embodiments of the present invention have been described in detail above in conjunction with the accompanying drawings. However, the present invention is not limited to the above embodiments, and various changes can be made without departing from the spirit of the present invention within the scope of knowledge possessed by those of ordinary skill in the art.

Claims

1. A cream for treating acne, including the formula of the cream and the preparation of the cream, characterized in that, The formula of the cream includes: Notoginseng root extract 0.05%, Smilax glabra extract 0.085%, borneol 1%, camphor 1%, thymol 0.5%, willow branch extract (containing 1.5% salicylic acid), carbomer 0.2% - 0.4%, xanthan gum 0.2% - 0.4%, liquid paraffin 1% - 3%, caprylic / capric triglyceride 1% - 2%, cetearyl olivate 1% - 2%, synthetic beeswax 2% - 3%, polydimethylsiloxane 2% - 3%, ethanol 3% - 6%; The preparation of the cream includes the following steps: Step 1: Add water, glycerol, p-hydroxyacetophenone, hexylene glycol, carbomer, xanthan gum, allantoin, and disodium EDTA into the water phase pot, heat to 80°C - 85°C, and mix and stir well. Step 2: Add liquid paraffin, caprylic / capric triglyceride, cetearyl olivate, synthetic beeswax, and polydimethylsiloxane into the oil phase pot, heat to 80°C - 85°C, and mix and stir well. Step 3: Preheat the main pot to 80°C - 85°C, and pump the raw materials prepared in Step 1 and Step 2 into the main pot respectively, and homogenize, stir, and mix well. Step 4: Stir and cool to 60°C ± 2°C, add propylene glycol and salicylic acid that have been dissolved evenly in advance, and mix and stir well. Step 5: Stir and cool to below 45°C, and sequentially add notoginseng root extract, Smilax glabra extract, ethanol, borneol, camphor, and thymol, and mix and stir well. Step 6: Stir and cool to room temperature, discharge to obtain semi-finished products, and conduct sampling inspection and material transfer. Step 7: Fill and package the qualified semi-finished products, and store them in the warehouse after passing the final product inspection.

2. The cream for treating acne according to claim 1, wherein, The notoginsenosides in the notoginseng root extract can inhibit Propionibacterium acnes, and the minimum inhibitory concentration is 0.5 - 1 mg / mL, and it can also damage the bacterial cell membrane.

3. The cream for treating acne according to claim 1, characterized in that, The 1% ethanol solution of borneol has an inhibition zone diameter of 15 mm against Propionibacterium acnes and can damage the bacterial biofilm structure.

4. The cream for treating acne according to claim 1, characterized in that, The 2% cream of camphor can achieve an antibacterial rate of 75% against Propionibacterium acnes and exerts a bactericidal effect by damaging the lipid structure of the bacterial cell membrane; It has an inhibitory effect on the infections related to folliculitis caused by Malassezia, and the MIC value is 0.5%.

5. A cream for treating acne according to claim 1, characterized in that, The MIC of thymol against Propionibacterium acnes is 0.06% - 0.25%, and it can penetrate the biofilm formed by Propionibacterium acnes to enhance the bactericidal effect.

6. The cream for treating acne according to claim 1, wherein The salicylic acid cooperates with other ingredients to play an antibacterial and keratin metabolism-promoting role in the cream, which helps to treat acne.

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