Anti-aging antibacterial oil agent for skin mucous membrane elasticity recovery and tightening and preparation method of anti-aging antibacterial oil agent

Abstract

The invention discloses an anti-aging antibacterial oil agent for skin mucosa elasticity recovery and tightening and a preparation method of the anti-aging antibacterial oil agent. The formula consists of the following raw materials: saffron crocus extract, centella asiatica extract, vetiver extract, motherwort herb extract, blackend swallowwort root extract, Chinese ligusticum rhizome extract, spirulina platensis extract, peony extract, lysostaphin, rice germ fermented oil, superoxide dismutase, sodium hyaluronate and peony peptide. And lactoferrin. The herba leonuri extract is added to prevent skin aging and achieve the anti-aging effect, the peony extract and superoxide dismutase can also achieve the anti-aging effect, and peony peptide can stimulate skin cells to synthesize more collagen, so that the elasticity and compactness of the skin are enhanced, the elasticity of the skin mucosa can be recovered, and the skin quality is improved. Therefore, on the basis of bacteriostasis, the skin mucous membrane elasticity can be repaired, and the skin mucous membrane is tightened and anti-aging.

Description

Technical Field

[0001] The present invention relates to the field of pharmaceutical technology, and particularly to an oil agent for restoring skin and mucous membrane elasticity, tightening, anti-aging and inhibiting bacteria, and a preparation method thereof. Background Art

[0002] Due to various reasons, the vagina of the female reproductive system can be infected by pathogens, or the vaginal environment can change due to problems with the balance of vaginal flora and acid-base balance, resulting in vaginal bleeding or various gynecological diseases. From a traditional Chinese medicine perspective, the etiology and pathogenesis of mycotic vaginitis are mostly due to spleen deficiency generating dampness, and dampness pouring downward to the lower energizer. The etiology and pathogenesis of trichomonal vaginitis are mainly due to stagnation of liver qi generating heat and heat accumulating to form worms. The main mechanism of the etiology and pathogenesis of senile vaginitis is liver-kidney yin deficiency and damp-heat pouring downward. In Western medicine, it is mainly considered to be caused by virus or germ infection. Vaginitis brings long-term health and life troubles to women, and even seriously affects mental health. Some existing vaginal antibacterial gels only have antibacterial effects and lack skin repair and anti-aging effects. Summary of the Invention

[0003] Aiming at the defects of the prior art, the purpose of the present invention is to provide an oil agent for restoring skin and mucous membrane elasticity, tightening, anti-aging and inhibiting bacteria, and a preparation method thereof, so as to solve the problems raised in the above background art.

[0004] The present invention adopts the following technical solutions to solve the technical problems:

[0005] The present invention provides an oil agent for restoring skin and mucous membrane elasticity, tightening, anti-aging and inhibiting bacteria, and the formula is composed of the following raw materials: saffron extract, centella asiatica extract, vetiver extract, motherwort extract, cynanchum atratum extract, ligusticum sinense extract, spirulina platensis extract, peony extract, lysostaphin, rice germ fermented oil, superoxide dismutase, sodium hyaluronate, peony peptide, lactoferrin.

[0006] Preferably, the formula is composed of the following raw materials by weight: saffron extract 0.7-0.9%, centella asiatica extract 2-3%, vetiver extract 3-5%, motherwort extract 1-3%, cynanchum atratum extract 2-4%, ligusticum sinense extract 1-3%, spirulina platensis extract 0.3-1.1%, peony extract 1-3%, lysostaphin 18-32%, rice germ fermented oil 8-10%, sodium hyaluronate 5-9%, superoxide dismutase 20-30%, peony peptide 3-5%, lactoferrin 10-16%.

[0007] Preferably, the formula consists of the following raw materials by weight: saffron extract 0.7%, centella asiatica extract 3%, vetiver extract 3%, motherwort extract 3%, cynanchum atratum extract 2%, ligusticum sinense extract 3%, spirulina platensis extract 0.3%, peony extract 3%, lysostaphin 18%, rice germ fermented oil 10%, sodium hyaluronate 5%, superoxide dismutase 30%, peony peptide 3%, lactoferrin 16%.

[0008] Preferably, the formula consists of the following raw materials by weight: saffron extract 0.8%, centella asiatica extract 2.5%, vetiver extract 4%, motherwort extract 2%, cynanchum atratum extract 3%, ligusticum sinense extract 2%, spirulina platensis extract 0.7%, peony extract 2%, lysostaphin 25%, rice germ fermented oil 9%, sodium hyaluronate 7%, superoxide dismutase 25%, peony peptide 4%, lactoferrin 13%.

[0009] Preferably, the formula consists of the following raw materials by weight: saffron extract 0.9%, centella asiatica extract 2%, vetiver extract 5%, motherwort extract 1%, cynanchum atratum extract 4%, ligusticum sinense extract 1%, spirulina platensis extract 1.1%, peony extract 1%, lysostaphin 32%, rice germ fermented oil 8%, sodium hyaluronate 9%, superoxide dismutase 20%, peony peptide 5%, lactoferrin 10%.

[0010] Preferably, the peony extract is peony flower extract, peony leaf extract and peony root extract.

[0011] Preferably, the vetiver extract is vetiver oil, and the preparation method of the vetiver oil comprises the following steps: appropriately pulverize the dry vetiver roots into powder, weigh 10 g of vetiver powder with a mesh size of 20 - 100 meshes, put it into a 500 mL Erlenmeyer flask, add absolute ethanol according to the solid-liquid ratio of 1:30, extract in an ultrasonic extraction device for 15 - 25 min, take out the Erlenmeyer flask, filter by suction, and after the filtrate is dewaxed by freezing, rotary evaporate to remove ethanol under low temperature conditions to obtain the vetiver extract, i.e., vetiver oil.

[0012] Saffron extract: Saffron can effectively repair tissues and accelerate wound healing. By virtue of its drug components such as carotenoids, volatile oils, and glycosides, it can form an effective protective film on the wound surface, blocking the invasion of external pathogens and bacteria. At the same time, saffron can effectively improve the cell oxygen metabolism mechanism, has a certain inhibitory effect on blood coagulation function, can effectively prolong the activation and generation time of prothrombin, improve the whole blood specific viscosity, and local application can effectively improve the wound blood circulation, remove inflammatory edema, accelerate the shedding of necrotic tissue on the wound surface, promote the regeneration of granulation tissue, and thus promote wound healing. Moreover, saffron has little irritation to the wound surface. At the same time, saffron extract has antibacterial effects and has good antibacterial effects on candida albicans.

[0013] Centella asiatica extract: Centella asiatica extract has certain effects of soothing and repairing the skin.

[0014] Vetiver extract: Vetiver oil has certain inhibitory effects on Escherichia coli, Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus licheniformis, and Bacillus altitudinis.

[0015] Leonurus japonicus extract: Leonurus japonicus extract can increase the number of fibroblasts, stimulate fibroblasts in the dermis, promote the division of fibroblasts and their ability to synthesize and secrete collagen and elastin, promote the recovery of skin elastic vitality, and has the effect of preventing skin aging.

[0016] Cynanchum atratum extract: Cynanchum atratum is rich in various active ingredients such as C 21 steroidal saponins, acetophenone derivatives, and alkaloids. Among them, C 21 steroidal saponins have many pharmacological effects such as antibacterial, anti-inflammatory, anti-tumor, improving memory, immunosuppressive, whitening, and improving liver injury. The pharmacological effects of acetophenone derivatives include whitening, antioxidant, etc.; alkaloids have antibacterial, antiviral and other pharmacological effects.

[0017] Ligusticum sinense extract: It has the effects of removing dampness, dispelling cold and relieving pain, bacteriostasis, anti-inflammation, antioxidant, etc.

[0018] Spirulina platensis extract: Spirulina is rich in natural antioxidants such as phycocyanin, β-carotene, vitamins, and minerals, so it has strong antioxidant properties. These substances can effectively scavenge residual free radicals in the body, prevent DNA damage, increase the activities of superoxide dismutase and catalase, significantly reduce oxidative stress reactions, that is, reduce the attack of free radicals on cells, maintain the stability of the internal and external environments of cells, and maintain normal cell metabolism of the body.

[0019] Peony Extract: The extract of peony flower has the ability to resist Staphylococcus aureus and Escherichia coli. The extract of peony flower achieves the antibacterial effect by destroying the integrity of the cell membrane and inhibiting the transcriptional level of virulence factors. The main component of peony root extract, paeonol, can significantly inhibit the phosphorylation of mitogen-activated protein kinase and activator protein 1 in UVB-induced keratinocytes, prevent the degradation of type I procollagen, promote epidermal regeneration, improve the ultrastructure of damaged skin tissue, and has the effect of repairing and thickening the skin. Peony root extract can regulate cell proliferation and differentiation by controlling the key regulator ATG5 of the autophagy pathway, and then affect the skin aging process to play an anti-aging role. Peony leaf extract contains rich active ingredients and nutrients. The polysaccharides in peony leaves can scavenge hydroxyl free radicals and have anti-aging effects. Peony leaf extract can inhibit the activity of tyrosinase and has multiple effects such as antibacterial, antioxidant, and inhibiting tyrosinase. Paeonol, gallic acid, and flavonoids in peony leaves can inhibit a variety of bacteria.

[0020] Superoxide Dismutase: Utilizing its antioxidant properties, it delays skin aging, effectively removes spots and resists wrinkles. Superoxide dismutase has the function of scavenging oxygen free radicals. The most important application purpose of superoxide dismutase for antioxidant is to delay skin aging. Free radicals can accelerate the breakage of elastic fibers in skin tissue and the destruction of skin connective tissue, resulting in a decrease in skin tissue elasticity. At the same time, it causes deformative damage to sebaceous glands in skin tissue, reduces sebum secretion, weakens the moisturizing effect, and increases wrinkles. Superoxide dismutase scavenges free radicals in the human body, inhibits oxidation, makes the target substance no longer attacked by free radicals, blocks the production of hard elastase, and inhibits its activity, improving the health condition of the skin from the inside. Long-term use of products containing superoxide dismutase can supply nutrients to the skin surface, restore the functions of skin cells, refine skin tissue, reduce wrinkles, play an anti-wrinkle role, and at the same time fade various spots and delay skin aging. Superoxide dismutase has an anti-inflammatory effect and is natural, non-toxic and has no side effects.

[0021] Lysostaphin: Lysostaphin has antibacterial effects on Staphylococcus bacteria, mainly because its effective target, the gly pentapeptide bridge, is typically present in the peptidoglycan cross-linking structure of the Staphylococcus cell wall, and different Staphylococcus have significant differences in their sensitivity to it. Among them, Staphylococcus aureus has the highest sensitivity, which is related to the high proportion of gly pentapeptide bridges in the peptidoglycan cross-linking structure of the Staphylococcus aureus cell wall. Others such as Staphylococcus epidermidis have lower sensitivity. The exact site where lysostaphin breaks the peptidoglycan gly pentapeptide bridge structure is to specifically hydrolyze the peptide bond formed between the 2nd gly and the 3rd gly of the gly pentapeptide bridge.

[0022] Rice Germ Fermented Oil: It has antioxidant effects and can significantly reduce the secretion amount of cell inflammation, thus being able to play a soothing effect.

[0023] Sodium hyaluronate: Sodium hyaluronate itself, as an important component of the extracellular matrix, has good pharmacodynamic activities such as lubricating joints and tissues, anti-inflammatory effects, and promoting wound healing. This enables sodium hyaluronate, while acting as a pharmaceutical excipient to improve the solubility of the loaded drug and enhance its bioavailability, to also have the function of synergistically enhancing the pharmacodynamic activity of the loaded drug.

[0024] Lactoferrin: One of the most important functions of lactoferrin is its antibacterial effect. Lactoferrin belongs to a broad-spectrum bacteriostatic agent, which can inhibit both iron-requiring Gram-negative bacteria (such as coliforms, Salmonella, etc.) and Gram-positive bacteria (such as Staphylococcus aureus). The polypeptides produced after lactoferrin is degraded by protease also have antibacterial effects.

[0025] Peony peptide: Peony peptide has strong antioxidant ability, can scavenge free radicals in the body, thereby slowing down the rate of cell aging and achieving the effect of anti-aging. Peony peptide has certain anti-inflammatory and antibacterial effects. Peony peptide can stimulate skin cells to synthesize more collagen, thereby enhancing the elasticity and firmness of the skin.

[0026] The present invention also provides a method for preparing an oil agent for restoring skin and mucosal elasticity, tightening, anti-aging, and antibacterial, comprising the following steps: weighing each raw material, adding each raw material to purified water and mixing to obtain a mixture, the mixing temperature is 35 - 45 °C, and the pH value is adjusted to 5.5 - 6.5.

[0027] Compared with the prior art, the present invention has the following beneficial effects:

[0028] In the present invention, the motherwort extract added can increase the number of fibroblasts, stimulate the fibroblasts in the dermis, promote the division of fibroblasts and their ability to synthesize and secrete collagen and elastin, promote the recovery of skin elastic vitality, play an anti-aging effect by preventing skin aging. The peony extract and superoxide dismutase can also play an anti-aging effect. Peony peptide can stimulate skin cells to synthesize more collagen, thereby enhancing the elasticity and firmness of the skin, enabling the restoration of skin and mucosal elasticity, so that the present application can repair skin and mucosal elasticity and tighten and anti-age on the basis of antibacterial. Detailed implementation manners

[0029] The following combines specific embodiments to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts belong to the scope of protection of the present invention.

[0030] Example 1.

[0031] A skin and mucous membrane elasticity restoration, tightening, anti-aging and antibacterial oil agent of this embodiment has a formula composed of the following raw materials: saffron extract, centella asiatica extract, vetiver extract, motherwort extract, cynanchum atratum extract, ligusticum sinense extract, spirulina platensis extract, peony extract, lysostaphin, rice germ fermented oil, superoxide dismutase, sodium hyaluronate, peony peptide, lactoferrin.

[0032] The formula of this embodiment is composed of the following raw materials by weight: the formula is composed of the following raw materials by weight: saffron extract 0.7%, centella asiatica extract 3%, vetiver extract 3%, motherwort extract 3%, cynanchum atratum extract 2%, ligusticum sinense extract 3%, spirulina platensis extract 0.3%, peony extract 3%, lysostaphin 18%, rice germ fermented oil 10%, sodium hyaluronate 5%, superoxide dismutase 30%, peony peptide 3%, lactoferrin 16%.

[0033] The peony extract of this embodiment is peony flower extract, peony leaf extract and peony root extract.

[0034] The vetiver extract of this embodiment is vetiver oil, and the preparation method of the vetiver oil includes the following steps: appropriately pulverize the dry vetiver roots into powder, weigh 10 g of 20-mesh vetiver powder, put it into a 500 mL Erlenmeyer flask, add absolute ethanol according to the solid-liquid ratio of 1:30, extract in an ultrasonic extraction device for 15 min, take out the Erlenmeyer flask, filter by suction, and after the filtrate is dewaxed by freezing, rotary evaporate to remove ethanol under low temperature conditions to obtain the vetiver extract, that is, vetiver oil.

[0035] A preparation method of a skin and mucous membrane elasticity restoration, tightening, anti-aging and antibacterial oil agent of this embodiment includes the following steps:

[0036] It includes the following steps: weigh each raw material, add each raw material to purified water and mix to obtain, the mixing temperature is 35°C, and adjust the pH value to 5.5.

[0037] Example 2.

[0038] A skin and mucous membrane elasticity restoration, tightening, anti-aging and antibacterial oil agent of this embodiment has a formula composed of the following raw materials: saffron extract, centella asiatica extract, vetiver extract, motherwort extract, cynanchum atratum extract, ligusticum sinense extract, spirulina platensis extract, peony extract, lysostaphin, rice germ fermented oil, superoxide dismutase, sodium hyaluronate, peony peptide, lactoferrin.

[0039] The formula of this embodiment consists of raw materials with the following weights: The formula consists of the following raw materials by weight: saffron extract 0.8%, centella asiatica extract 2.5%, vetiver extract 4%, motherwort extract 2%, cynanchum atratum extract 3%, ligusticum sinense extract 2%, spirulina platensis extract 0.7%, peony extract 2%, lysostaphin 25%, rice germ fermented oil 9%, sodium hyaluronate 7%, superoxide dismutase 25%, peony peptide 4%, lactoferrin 13%.

[0040] The peony extract in this embodiment is peony flower extract, peony leaf extract and peony root extract.

[0041] The vetiver extract in this embodiment is vetiver oil, and the preparation method of the vetiver oil includes the following steps: Appropriately crush the dry vetiver roots into powder, weigh 10 g of 60-mesh vetiver powder, put it into a 500 mL Erlenmeyer flask, add absolute ethanol according to the solid-liquid ratio of 1:30, extract in an ultrasonic extraction device for 20 min, take out the Erlenmeyer flask, filter by suction, and after the filtrate is dewaxed by freezing, rotary evaporate to remove ethanol under low temperature conditions to obtain the vetiver extract, that is, vetiver oil.

[0042] A preparation method of an oil agent for restoring skin and mucous membrane elasticity, tightening, anti-aging and antibacterial in this embodiment includes the following steps:

[0043] It includes the following steps: Weigh each raw material, add each raw material to purified water and mix to obtain, the mixing temperature is 40°C, and adjust the pH value to 6.0.

[0044] Example 3.

[0045] An oil agent for restoring skin and mucous membrane elasticity, tightening, anti-aging and antibacterial in this embodiment, the formula consists of the following raw materials: saffron extract, centella asiatica extract, vetiver extract, motherwort extract, cynanchum atratum extract, ligusticum sinense extract, spirulina platensis extract, peony extract, lysostaphin, rice germ fermented oil, superoxide dismutase, sodium hyaluronate, peony peptide, lactoferrin.

[0046] The formula of this embodiment consists of raw materials with the following weights: The formula consists of the following raw materials by weight: saffron extract 0.9%, centella asiatica extract 2%, vetiver extract 5%, motherwort extract 1%, cynanchum atratum extract 4%, ligusticum sinense extract 1%, spirulina platensis extract 1.1%, peony extract 1%, lysostaphin 32%, rice germ fermented oil 8%, sodium hyaluronate 9%, superoxide dismutase 20%, peony peptide 5%, lactoferrin 10%.

[0047] The peony extract in this embodiment is peony flower extract, peony leaf extract and peony root extract.

[0048] The vetiver extract in this example is vetiver oil, and the preparation method of the vetiver oil includes the following steps: appropriately crush the dry vetiver roots into powder, weigh 10 g of 100-mesh vetiver powder, put it into a 500 mL Erlenmeyer flask, add absolute ethanol according to the material-liquid ratio of 1:30, extract in an ultrasonic extraction device for 25 min, take out the Erlenmeyer flask, filter by suction, and after removing wax by freezing the filtrate, rotary evaporate to remove ethanol under low temperature conditions to obtain the vetiver extract, i.e., vetiver oil.

[0049] The preparation method of a skin and mucous membrane elasticity recovery, tightening, anti-aging and bacteriostatic oil agent in this example includes the following steps:

[0050] It includes the following steps: weigh each raw material, add each raw material to purified water and mix to obtain, the mixing temperature is 45 °C, and adjust the pH value to 6.5.

[0051] At the same time, conduct microbiological index detection on the prepared skin and mucous membrane elasticity recovery, tightening, anti-aging and bacteriostatic oil agent of the invention:

[0052] I. Equipment

[0053] 1. Sample name: "The skin and mucous membrane elasticity recovery, tightening, anti-aging and bacteriostatic oil agent prepared in Example 2".

[0054] 2. STX1202ZH electronic balance.

[0055] 3. Ordinary nutrient agar medium, Sabouraud agar medium, SCDLP liquid medium, lactose bile salt fermentation medium, blood agar plate, glucose broth.

[0056] 4. HPX-9272MBE electrothermal constant temperature incubator.

[0057] 5. Sterile graduated pipettes, sterile petri dishes, sterile test tubes, scissors, forceps, alcohol lamps, etc.

[0058] II. Methods

[0059] Inspection basis: Conduct according to Appendix B2, B7, B3, B5, B4, B6 of GB 15979-2002 "Hygienic Standards for Disposable Sanitary Products".

[0060] III. Results

[0061] Detection indicators Technical requirements Test results Total number of bacterial colonies (cfu / g) ≤200 ＜20 Total number of fungal colonies (cfu / g) ≤100 ＜20 Escherichia coli Not detected Not detected Staphylococcus aureus Not detected Not detected Candida albicans Not detected Not detected Pseudomonas aeruginosa Not detected Not detected Hemolytic streptococcus Not detected Not detected

[0062] From the above results, it can be seen that the prepared skin and mucous membrane elasticity recovery, tightening, anti-aging and bacteriostatic oil agent of this application has a bacteriostatic effect.

[0063] Bacteriostatic stability test

[0064] I. Equipment

[0065] 1 Test strains: Escherichia coli (8099), cultured for 3 generations; Candida albicans (ATCC10231), cultured for 3 generations; Staphylococcus aureus (ATCC6538), cultured for 3 generations, provided by China Center for Type Culture Collection.

[0066] 2. Ordinary nutrient agar medium and Sabouraud agar medium, provided by Beijing Land Bridge Technology Co., Ltd.

[0067] 3. 0.03mol / L phosphate buffer solution (PBS).

[0068] 4. Carriers: filter paper (2.0cm x 3.0cm), sterile graduated pipette, sterile petri dish, sterile test tube, constant temperature incubator, etc.

[0069] II. Methods

[0070] 1. Sample treatment: Put the sample into a sterile mortar and mix well. Weigh 5g and put it into a sterile petri dish, in accordance with Appendix C4 of GB15979-2002 Hygiene Standard for Disposable Sanitary Products.

[0071] 2. The antibacterial test is a carrier test. The test temperature is 20°C ± 1°C, and the test is repeated three times.

[0072] III. Results

[0073] Under the condition that the test temperature is 20°C ± 1°C, the average antibacterial rates of the original sample of the tested sample "Skin and Mucous Membrane Elasticity Restoration, Tightening, Anti-aging and Antibacterial Oil Agent Prepared in Example 2" against Escherichia coli (8099), Candida albicans (ATCC10231), and Staphylococcus aureus (ATCC6538) were measured.

[0074] Antibacterial effect against Escherichia coli

[0075]

[0076] Antibacterial effect against Candida albicans

[0077]

[0078] Antibacterial effect against Staphylococcus aureus

[0079]

[0080] Conclusion of the above tests: The inhibition rates of Example 2 against Escherichia coli, Candida albicans, and Staphylococcus aureus can reach over 90%.

[0081] To demonstrate the clinical application effect of the present invention, the present invention has been proven through clinical experimental research: the composition of the embodiment was tested on people of different age groups and different gynecological diseases. Through the test, this product is used for antibacterial, cleaning, odor removal and daily care of the female vulva, promoting health. At the same time, on the basis of antibacterial, it can also repair the elasticity of skin mucosa and tighten and resist aging.

[0082] For those skilled in the art, it is obvious that the present invention is not limited to the details of the above exemplary embodiments, and the present invention can be implemented in other specific forms without departing from the spirit or basic characteristics of the present invention. Therefore, from any point of view, the embodiments should be regarded as exemplary and non-limiting. The scope of the present invention is defined by the appended claims rather than the above description. Therefore, all changes falling within the meaning and scope of the equivalent elements of the claims are intended to be included in the present invention.

[0083] In addition, it should be understood that although this specification is described according to embodiments, not every embodiment only contains an independent technical solution. This narrative way of the specification is only for clarity. Those skilled in the art should regard the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A skin and mucous membrane elasticity restoring, tightening, anti-aging and antibacterial oil agent, characterized in that, The formula consists of the following raw materials: saffron extract, centella asiatica extract, vetiver extract, motherwort extract, cynanchum atratum extract, ligusticum sinense extract, spirulina platensis extract, peony extract, lysostaphin, rice germ fermented oil, superoxide dismutase, sodium hyaluronate, peony peptide, lactoferrin.

2. The skin and mucous membrane elasticity restoring, tightening, anti-aging and bacteriostatic oil agent according to claim 1, wherein The formula consists of the following raw materials by weight: saffron extract 0.7 - 0.9%, centella asiatica extract 2 - 3%, vetiver extract 3 - 5%, motherwort extract 1 - 3%, cynanchum atratum extract 2 - 4%, ligusticum sinense extract 1 - 3%, spirulina platensis extract 0.3 - 1.1%, peony extract 1 - 3%, lysostaphin 18 - 32%, rice germ fermented oil 8 - 10%, sodium hyaluronate 5 - 9%, superoxide dismutase 20 - 30%, peony peptide 3 - 5%, lactoferrin 10 - 16%.

3. The skin and mucous membrane elasticity restoring, tightening, anti-aging and bacteriostatic oil agent according to claim 1, characterized in that, The formula consists of the following raw materials by weight: saffron extract 0.7%, centella asiatica extract 3%, vetiver extract 3%, motherwort extract 3%, cynanchum atratum extract 2%, ligusticum sinense extract 3%, spirulina platensis extract 0.3%, peony extract 3%, lysostaphin 18%, rice germ fermented oil 10%, sodium hyaluronate 5%, superoxide dismutase 30%, peony peptide 3%, lactoferrin 16%.

4. The skin and mucosa elasticity restoring, tightening, anti-aging and bacteriostatic oil agent according to claim 1, characterized in that, The formula consists of the following raw materials by weight: saffron extract 0.8%, centella asiatica extract 2.5%, vetiver extract 4%, motherwort extract 2%, cynanchum atratum extract 3%, ligusticum sinense extract 2%, spirulina platensis extract 0.7%, peony extract 2%, lysostaphin 25%, rice germ fermented oil 9%, sodium hyaluronate 7%, superoxide dismutase 25%, peony peptide 4%, lactoferrin 13%.

5. The skin and mucosa elasticity restoring, tightening, anti-aging and antibacterial oil agent according to claim 1, wherein The formula consists of the following raw materials by weight: saffron extract 0.9%, centella asiatica extract 2%, vetiver extract 5%, motherwort extract 1%, cynanchum atratum extract 4%, ligusticum sinense extract 1%, spirulina platensis extract 1.1%, peony extract 1%, lysostaphin 32%, rice germ fermented oil 8%, sodium hyaluronate 9%, superoxide dismutase 20%, peony peptide 5%, lactoferrin 10%.

6. The skin and mucosa elasticity restoring, tightening, anti-aging and bacteriostatic oil agent according to claim 1, characterized in that The peony extract is peony flower extract, peony leaf extract and peony root extract.

7. The skin and mucosa elasticity restoring, tightening, anti-aging and bacteriostatic oil agent according to claim 1, wherein The vetiver extract is vetiver oil, and the preparation method of the vetiver oil includes the following steps: appropriately pulverize the dry vetiver roots into powder, weigh 10 g of vetiver powder with 20 - 100 mesh, put it into a 500 mL Erlenmeyer flask, add absolute ethanol according to the solid - liquid ratio of 1:30, extract in an ultrasonic extraction device for 15 - 25 min, take out the Erlenmeyer flask, filter by suction, and after the filtrate is defatted by freezing, rotate and evaporate to remove ethanol under low - temperature conditions to obtain the vetiver extract, i.e., vetiver oil.

8. A preparation method of a skin and mucous membrane elasticity restoration, tightening, anti-aging and antibacterial oil agent according to any one of claims 1-7, characterized in that, It includes the following steps: weigh each raw material, add each raw material to purified water and mix to obtain, the mixing temperature is 35 - 45 °C, and adjust the pH value to 5.5 - 6.5.

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