A plant composition with anti-redness and antipruritic effects, its preparation method and application.

Abstract

This invention relates to a plant composition with redness-reducing and itch-relieving effects, its preparation method, and its application, belonging to the field of daily chemical technology; the plant composition contains the following raw materials: peony extract, ophiopogon japonicus extract, scutellaria baicalensis extract, atractylodes macrocephala powder, andrographis paniculata powder, chamomile extract, and forsythia suspensa root extract; the plant composition has the effects of reducing redness and itch-relieving, and is suitable for use in skin care products.

Description

Technical Field

[0001] This invention belongs to the field of daily chemical technology, specifically relating to a plant composition with the effects of reducing redness and relieving itching, its preparation method and application. Background Technology

[0002] As the largest organ in the human body, the skin acts as a protective barrier, blocking the invasion of harmful external substances, and also participates in the body's metabolic and secretory processes. Its health directly affects a person's physical and mental well-being. However, against the backdrop of a fast-paced lifestyle, severe air pollution, and increased ultraviolet radiation, skin problems such as redness and itching are becoming increasingly common, seriously interfering with people's daily work and social interactions. In response to these problems, a large number of soothing skincare products have emerged on the market. Soothing skincare products refer to skincare products containing soothing ingredients, and they are typically formulated according to different... Some skincare products are specially formulated for various skin problems. Some focus on quick redness reduction by adding soothing factors to reduce redness, while others emphasize long-lasting itch relief by using repairing ingredients to strengthen the skin barrier and alleviate itching. However, most of these soothing skincare products can only offer one of the two options: reducing redness or relieving itching. The soothing ingredients they contain are unlikely to have both effects simultaneously. If consumers are facing the dual problems of redness and itching, they will have to use two or more soothing skincare products, which not only increases the complexity of skincare but may also lead to reduced effectiveness due to compatibility issues.

[0003] Based on the above shortcomings, there is an urgent need to provide a skin care product that can both reduce redness and relieve itching for consumers to choose from. Summary of the Invention

[0004] In view of the problems existing in the prior art, the purpose of this invention is to provide a plant composition with the effects of reducing redness and relieving itching, as well as its preparation method and application.

[0005] To achieve the above objectives, the technical solution adopted by the present invention is as follows:

[0006] In a first aspect, the present invention provides a plant composition having the effect of reducing redness and relieving itching, the plant composition comprising the following raw materials in parts by weight:

[0007] 8-12 parts of peony extract;

[0008] 10-15 parts of Ophiopogon japonicus extract;

[0009] 6-8 parts of Scutellaria baicalensis extract;

[0010] 5-7 parts of Atractylodes macrocephala powder;

[0011] 3-5 parts of Andrographis paniculata powder.

[0012] Preferably, the plant composition comprises the following parts by weight of raw materials:

[0013] 9-11 parts of peony extract;

[0014] 11-13 parts of Ophiopogon japonicus extract;

[0015] 6-7 parts of Scutellaria baicalensis extract;

[0016] 6-7 parts of Atractylodes macrocephala powder;

[0017] 4-5 parts of Andrographis paniculata powder.

[0018] Preferably, the plant composition comprises the following parts by weight of raw materials:

[0019] 10 parts of peony extract;

[0020] 12 parts of Ophiopogon japonicus extract;

[0021] 7 parts of Scutellaria baicalensis extract;

[0022] 6 parts of Atractylodes macrocephala powder;

[0023] Five portions of Andrographis paniculata powder.

[0024] Preferably, the method for preparing the plant composition includes the following steps:

[0025] (1) Mix the Atractylodes macrocephala powder and Andrographis paniculata powder, which have passed through a 100-mesh sieve respectively, according to the formula to obtain a mixed powder;

[0026] (2) The mixed powder was extracted using a eutectic solvent to obtain Atractylodes macrocephala-Andrographis paniculata extract;

[0027] (3) Mix the prescribed amounts of peony extract, ophiopogon extract, scutellaria extract and atractylodes-andrographis extract evenly to obtain a plant composition;

[0028] The eutectic solvent is composed of a hydrogen bond acceptor, a hydrogen bond donor, and deionized water, wherein the molar ratio of the hydrogen bond acceptor, hydrogen bond donor, and deionized water is 1:3-5:1.5-2.5. The hydrogen bond acceptor is choline chloride, and the hydrogen bond donor is 1,4-butanediol. The preparation steps of the eutectic solvent are as follows: the hydrogen bond donor, hydrogen bond acceptor, and deionized water are mixed and heated and stirred at 80-100℃ for 1-3 hours to obtain the eutectic solvent.

[0029] The specific operation of step (2) is as follows:

[0030] The mixed powder and the eutectic solvent were mixed at a ratio of 1g:20-30g / mL. The mixture was ultrasonically treated for 30-40 minutes at an ultrasonic temperature of 50-60℃ and an ultrasonic power of 400-600W. After centrifugation at 3000-5000r / min for 10-20 minutes, the supernatant was collected and freeze-dried to obtain the Atractylodes macrocephala-Andrographis paniculata extract.

[0031] Preferably, the plant composition comprises the following raw materials in parts by weight:

[0032] 8-12 parts of peony extract;

[0033] 10-15 parts of Ophiopogon japonicus extract;

[0034] 6-8 parts of Scutellaria baicalensis extract;

[0035] 5-7 parts of Atractylodes macrocephala powder;

[0036] 3-5 parts of Andrographis paniculata powder;

[0037] 3-5 parts of chamomile extract;

[0038] Forsythia root extract 1-3 parts;

[0039] The method for preparing the plant composition includes the following steps:

[0040] (1) Mix the Atractylodes macrocephala powder and Andrographis paniculata powder, which have passed through a 100-mesh sieve respectively, according to the formula to obtain a mixed powder;

[0041] (2) The mixed powder was extracted using a eutectic solvent to obtain Atractylodes macrocephala-Andrographis paniculata extract;

[0042] (3) Mix the prescribed amounts of peony extract, ophiopogon extract, scutellaria extract, atractylodes macrocephala-andrographis paniculata extract, chamomile extract, and forsythia root extract evenly to obtain a plant composition;

[0043] The eutectic solvent is composed of a hydrogen bond acceptor, a hydrogen bond donor, and deionized water, wherein the molar ratio of the hydrogen bond acceptor, hydrogen bond donor, and deionized water is 1:3-5:1.5-2.5. The hydrogen bond acceptor is choline chloride, and the hydrogen bond donor is 1,4-butanediol. The preparation steps of the eutectic solvent are as follows: the hydrogen bond donor, hydrogen bond acceptor, and deionized water are mixed and heated and stirred at 80-100℃ for 1-3 hours to obtain the eutectic solvent.

[0044] The specific operation of step (2) is as follows:

[0045] The mixed powder and the eutectic solvent were mixed at a ratio of 1g:20-30g / mL. The mixture was ultrasonically treated for 30-40 minutes at an ultrasonic temperature of 50-60℃ and an ultrasonic power of 400-600W. After centrifugation at 3000-5000r / min for 10-20 minutes, the supernatant was collected and freeze-dried to obtain the Atractylodes macrocephala-Andrographis paniculata extract.

[0046] Secondly, the present invention provides an application of the plant composition described in the first aspect in the preparation of skin care products, wherein the dosage form of the skin care products is any one of face cream, serum, lotion, and mask.

[0047] Thirdly, the present invention provides an essence with the effects of reducing redness and relieving itching, the essence comprising the following components by weight percentage:

[0048] The first aspect describes a plant composition with redness-reducing and antipruritic effects, comprising 5-15%;

[0049] Moisturizer 25-35%;

[0050] Preservative 0.1-1%;

[0051] Replenish the solvent to 100%.

[0052] The humectant is glycerin; the preservative is phenoxyethanol and / or 1,2-hexanediol; and the solvent is deionized water.

[0053] The plant composition described in this invention, through the synergistic combination of various plant extracts, can achieve the effects of reducing redness and relieving itching, making it very suitable for use in skin care products.

[0054] The plant composition contains Scutellaria baicalensis extract, Andrographis paniculata powder, and Forsythia suspensa extract, which are rich in flavonoids, terpenes, glycosides, and other compounds. All three have significant anti-inflammatory and de-inflammatory capabilities, and can directly inhibit the expression of inflammatory factors, such as IL-6, at the source, regulate the occurrence of inflammatory responses, block signaling pathways, and thus relieve skin redness and itching.

[0055] Peony extract, Ophiopogon japonicus extract, Atractylodes macrocephala powder, and chamomile extract can indirectly soothe and reduce symptoms of skin redness and itching. Peony extract can delay the onset of symptoms and reduce skin stress by reducing the sensitivity of nerve endings. Ophiopogon japonicus extract can improve skin condition, accelerate the renewal of keratinocytes, and enhance the skin's resistance and defense against external stimuli and pro-inflammatory mediators. Atractylodes macrocephala powder can promote the secretion of anti-inflammatory factors, achieving repair and soothing effects, and reducing adverse reactions of skin cells internally. Chamomile extract helps repair the skin, especially for problem skin with existing symptoms, and can play a good "reconstruction" role, strengthening the barrier function as a whole.

[0056] The beneficial effects of this invention are as follows:

[0057] 1. The plant composition of the present invention uses peony extract, ophiopogon japonicus extract, scutellaria baicalensis extract, atractylodes macrocephala powder, andrographis paniculata powder, chamomile extract and forsythia extract as raw materials. Through the action of each raw material from different angles and mechanisms, it can produce excellent synergistic effects, and play a role in reducing redness and relieving itching. It is very suitable for use in skin care products.

[0058] 2. This invention uses a eutectic solvent to perform ultrasonic extraction on Atractylodes macrocephala powder and Andrographis paniculata powder. Compared with the traditional extraction method (ultrasonic extraction with ethanol), the Atractylodes macrocephala-Andrographis paniculata extract prepared by this invention has better effects in reducing redness and relieving itching.

[0059] 3. The plant composition prepared by this invention has low irritation and high safety, and has a good market application prospect. Detailed Implementation

[0060] To better illustrate the purpose, technical solution, and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0061] The sources of some of the raw materials used in the following examples and comparative examples are as follows:

[0062] Peony extract was purchased from Shaanxi Guanchen Biotechnology Co., Ltd., product number GC-01-89;

[0063] The Ophiopogon japonicus extract was purchased from Xi'an Sosite Biotechnology Co., Ltd., product number SOST-MD-2022;

[0064] Scutellaria baicalensis extract was purchased from Xi'an Ruiying Biotechnology Co., Ltd., product number RYHAQ20103;

[0065] The chamomile extract was purchased from Shaanxi Xinyanghe Biotechnology Co., Ltd., product number XYH-YGJ;

[0066] Forsythia root extract was purchased from Xi'an Jinheng Chemical Co., Ltd., product number JH01;

[0067] Both Atractylodes macrocephala powder and Andrographis paniculata powder were purchased from Bozhou Wufang Jiuru Pharmaceutical Co., Ltd.

[0068] Preparation of plant-based compositions with anti-redness and antipruritic effects

[0069] Example 1:

[0070] The raw materials and their mass fractions for the plant composition are as follows:

[0071] 10 parts of peony extract;

[0072] 12 parts of Ophiopogon japonicus extract;

[0073] 7 parts of Scutellaria baicalensis extract;

[0074] 6 parts of Atractylodes macrocephala powder;

[0075] 5 portions of Andrographis paniculata powder;

[0076] The method for preparing the plant composition includes the following steps:

[0077] (1) Mix the Atractylodes macrocephala powder and Andrographis paniculata powder, which have passed through a 100-mesh sieve respectively, according to the formula to obtain a mixed powder;

[0078] (2) Mix the mixed powder with the eutectic solvent at a ratio of 1g:25mL, sonicate at 55℃ and 500W for 35min, centrifuge at 4000r / min for 15min, take the supernatant, freeze dry to obtain Atractylodes macrocephala-Andrographis paniculata extract.

[0079] (3) Mix peony extract, ophiopogon extract, scutellaria extract, and atractylodes-andrographis extract evenly to obtain a plant composition;

[0080] The eutectic solvent is composed of choline chloride, 1,4-butanediol, and deionized water, wherein the molar ratio of choline chloride, 1,4-butanediol, and deionized water is 1:4:2. The preparation steps of the eutectic solvent are as follows: choline chloride, 1,4-butanediol, and deionized water are mixed and heated and stirred at 90°C for 2 hours to obtain the eutectic solvent.

[0081] Example 2:

[0082] The raw materials and their mass fractions for the plant composition are as follows:

[0083] 8 portions of peony extract;

[0084] 15 parts of Ophiopogon japonicus extract;

[0085] Six parts of Scutellaria baicalensis extract;

[0086] 7 parts of Atractylodes macrocephala powder;

[0087] 3 portions of Andrographis paniculata powder;

[0088] The method for preparing the plant composition includes the following steps:

[0089] (1) Mix the Atractylodes macrocephala powder and Andrographis paniculata powder, which have passed through a 100-mesh sieve respectively, according to the formula to obtain a mixed powder;

[0090] (2) Mix the mixed powder with the eutectic solvent at a ratio of 1g:20mL, sonicate at 50℃ and 600W for 30min, centrifuge at 3000r / min for 20min, take the supernatant, freeze dry to obtain Atractylodes macrocephala-Andrographis paniculata extract.

[0091] (3) Mix peony extract, ophiopogon extract, scutellaria extract, and atractylodes-andrographis extract evenly to obtain a plant composition;

[0092] The eutectic solvent is composed of choline chloride, 1,4-butanediol, and deionized water, wherein the molar ratio of choline chloride, 1,4-butanediol, and deionized water is 1:3:2.5. The preparation steps of the eutectic solvent are as follows: choline chloride, 1,4-butanediol, and deionized water are mixed and heated and stirred at 80°C for 3 hours to obtain the eutectic solvent.

[0093] Example 3:

[0094] The raw materials and their mass fractions for the plant composition are as follows:

[0095] 12 portions of peony extract;

[0096] 10 parts of Ophiopogon japonicus extract;

[0097] 8 parts of Scutellaria baicalensis extract;

[0098] 5 parts of Atractylodes macrocephala powder;

[0099] 5 portions of Andrographis paniculata powder;

[0100] The method for preparing the plant composition includes the following steps:

[0101] (1) Mix the Atractylodes macrocephala powder and Andrographis paniculata powder, which have passed through a 100-mesh sieve respectively, according to the formula to obtain a mixed powder;

[0102] (2) Mix the mixed powder with the eutectic solvent at a ratio of 1g:30mL, sonicate at 60℃ and 400W for 40min, centrifuge at 5000r / min for 10min, take the supernatant, freeze dry, and obtain Atractylodes macrocephala-Andrographis paniculata extract.

[0103] (3) Mix peony extract, ophiopogon extract, scutellaria extract, and atractylodes-andrographis extract evenly to obtain a plant composition;

[0104] The eutectic solvent is composed of choline chloride, 1,4-butanediol, and deionized water, wherein the molar ratio of choline chloride, 1,4-butanediol, and deionized water is 1:2:1.5. The preparation steps of the eutectic solvent are as follows: choline chloride, 1,4-butanediol, and deionized water are mixed and heated and stirred at 100°C for 1 hour to obtain the eutectic solvent.

[0105] Example 4:

[0106] The raw materials and their mass fractions for the plant composition are as follows:

[0107] 10 parts of peony extract;

[0108] 12 parts of Ophiopogon japonicus extract;

[0109] 7 parts of Scutellaria baicalensis extract;

[0110] 6 parts of Atractylodes macrocephala powder;

[0111] 5 portions of Andrographis paniculata powder;

[0112] Four parts of chamomile extract;

[0113] Two portions of Forsythia suspensa root extract;

[0114] The method for preparing the plant composition includes the following steps:

[0115] (1) Mix the Atractylodes macrocephala powder and Andrographis paniculata powder, which have passed through a 100-mesh sieve respectively, according to the formula to obtain a mixed powder;

[0116] (2) Mix the mixed powder with the eutectic solvent at a ratio of 1g:25mL, sonicate at 55℃ and 500W for 35min, centrifuge at 4000r / min for 15min, take the supernatant, freeze dry to obtain Atractylodes macrocephala-Andrographis paniculata extract.

[0117] (3) Mix peony extract, ophiopogon extract, scutellaria extract, and atractylodes-andrographis extract evenly to obtain a plant composition;

[0118] The eutectic solvent is composed of choline chloride, 1,4-butanediol, and deionized water, wherein the molar ratio of choline chloride, 1,4-butanediol, and deionized water is 1:4:2. The preparation steps of the eutectic solvent are as follows: choline chloride, 1,4-butanediol, and deionized water are mixed and heated and stirred at 90°C for 2 hours to obtain the eutectic solvent.

[0119] Example 5:

[0120] The raw materials and their mass fractions for the plant composition are as follows:

[0121] 10 parts of peony extract;

[0122] 12 parts of Ophiopogon japonicus extract;

[0123] 7 parts of Scutellaria baicalensis extract;

[0124] 6 parts of Atractylodes macrocephala powder;

[0125] 5 portions of Andrographis paniculata powder;

[0126] 5 parts of chamomile extract;

[0127] Forsythia root extract (3 parts);

[0128] The method for preparing the plant composition includes the following steps:

[0129] (1) Mix the Atractylodes macrocephala powder and Andrographis paniculata powder, which have passed through a 100-mesh sieve respectively, according to the formula to obtain a mixed powder;

[0130] (2) Mix the mixed powder with the eutectic solvent at a ratio of 1g:25mL, sonicate at 55℃ and 500W for 35min, centrifuge at 4000r / min for 15min, take the supernatant, freeze dry to obtain Atractylodes macrocephala-Andrographis paniculata extract.

[0131] (3) Mix peony extract, ophiopogon extract, scutellaria extract, and atractylodes-andrographis extract evenly to obtain a plant composition;

[0132] The eutectic solvent is composed of choline chloride, 1,4-butanediol, and deionized water, wherein the molar ratio of choline chloride, 1,4-butanediol, and deionized water is 1:4:2. The preparation steps of the eutectic solvent are as follows: choline chloride, 1,4-butanediol, and deionized water are mixed and heated and stirred at 90°C for 2 hours to obtain the eutectic solvent.

[0133] Example 6:

[0134] The raw materials and their mass fractions for the plant composition are as follows:

[0135] 10 parts of peony extract;

[0136] 12 parts of Ophiopogon japonicus extract;

[0137] 7 parts of Scutellaria baicalensis extract;

[0138] 6 parts of Atractylodes macrocephala powder;

[0139] 5 portions of Andrographis paniculata powder;

[0140] Three parts of chamomile extract;

[0141] One part of Forsythia root extract;

[0142] The method for preparing the plant composition includes the following steps:

[0143] (1) Mix the Atractylodes macrocephala powder and Andrographis paniculata powder, which have passed through a 100-mesh sieve respectively, according to the formula to obtain a mixed powder;

[0144] (2) Mix the mixed powder with the eutectic solvent at a ratio of 1g:25mL, sonicate at 55℃ and 500W for 35min, centrifuge at 4000r / min for 15min, take the supernatant, freeze dry to obtain Atractylodes macrocephala-Andrographis paniculata extract.

[0145] (3) Mix peony extract, ophiopogon extract, scutellaria extract, and atractylodes-andrographis extract evenly to obtain a plant composition;

[0146] The eutectic solvent is composed of choline chloride, 1,4-butanediol, and deionized water, wherein the molar ratio of choline chloride, 1,4-butanediol, and deionized water is 1:4:2. The preparation steps of the eutectic solvent are as follows: choline chloride, 1,4-butanediol, and deionized water are mixed and heated and stirred at 90°C for 2 hours to obtain the eutectic solvent.

[0147] Comparative Example 1:

[0148] Unlike the plant composition in Example 1, ethanol was used instead of the eutectic solvent for ultrasonic extraction of the mixed powder. The specific steps are as follows:

[0149] The mixed powder was mixed with 60wt% ethanol aqueous solution at a material-liquid ratio of 1g:25mL, and ultrasonically treated for 35min at an ultrasonic temperature of 55℃ and an ultrasonic power of 500W. After centrifugation at 4000r / min for 15min, the supernatant was collected and freeze-dried to obtain Atractylodes macrocephala-Andrographis paniculata extract.

[0150] The remaining raw materials and preparation parameters are the same as in Example 1.

[0151] Comparative Example 2:

[0152] Unlike the plant composition in Example 1, this example lacks peony extract, ophiopogon japonicus extract, and scutellaria baicalensis extract. The missing mass fractions are made up with deionized water. The remaining raw materials and preparation parameters are the same as in Example 1.

[0153] Comparative Example 3:

[0154] Unlike the plant composition in Example 1, this composition contains only peony extract, ophiopogon japonicus extract, and scutellaria baicalensis extract. The missing mass fractions are made up with deionized water. The other raw materials and preparation parameters are the same as in Example 1.

[0155] Comparative Example 4:

[0156] Unlike the plant composition in Example 1, this one lacks peony extract, and the missing mass is made up with deionized water. The other raw materials and preparation parameters are the same as in Example 1.

[0157] Comparative Example 5:

[0158] Unlike the plant composition in Example 1, this one lacks Ophiopogon japonicus extract, and the missing mass is made up with deionized water. The other raw materials and preparation parameters are the same as in Example 1.

[0159] Comparative Example 6:

[0160] Unlike the plant composition in Example 1, this one lacks Scutellaria baicalensis extract, and the missing mass fraction is made up with deionized water. The other raw materials and preparation parameters are the same as in Example 1.

[0161] Comparative Example 7:

[0162] Unlike the plant composition in Example 1, this composition contains only peony extract, with the missing mass amount made up with deionized water. The other raw materials and preparation parameters are the same as in Example 1.

[0163] Comparative Example 8:

[0164] Unlike the plant composition in Example 1, this composition contains only Ophiopogon japonicus extract, with the missing mass amount made up with deionized water. The other raw materials and preparation parameters are the same as in Example 1.

[0165] Comparative Example 9:

[0166] Unlike the plant composition in Example 1, this composition contains only Scutellaria baicalensis extract, with the missing mass amount made up with deionized water. The other raw materials and preparation parameters are the same as in Example 1.

[0167] Comparative Example 10:

[0168] Unlike the plant composition in Example 4, this one lacks chamomile extract, and the missing mass is made up with deionized water. The other raw materials and preparation parameters are the same as in Example 4.

[0169] Comparative Example 11:

[0170] Unlike the plant composition in Example 4, this one lacks Forsythia root extract, and the missing mass is made up with deionized water. The other raw materials and preparation parameters are the same as in Example 4.

[0171] Comparative Example 12:

[0172] Unlike the plant composition in Example 4, this composition contains only chamomile extract, with the missing mass made up with deionized water. The other raw materials and preparation parameters are the same as in Example 4.

[0173] Comparative Example 13:

[0174] Unlike the plant composition in Example 4, this composition contains only Forsythia root extract, with the missing mass made up by deionized water. The other raw materials and preparation parameters are the same as in Example 4.

[0175] Efficacy test

[0176] Preparation of test samples: The plant compositions in Examples 1-6 and the plant compositions in Comparative Examples 1-13 were mixed and stirred with the skin care product matrix at 45°C for 30 min, and then naturally cooled to room temperature to obtain the samples. The mass ratio of the plant compositions to the skin care product matrix was 3:97.

[0177] Preparation of blank samples: Deionized water and skincare product matrix were mixed and stirred at 45℃ for 30 min, and then naturally cooled to room temperature.

[0178] The mass ratio of the deionized water to the skin care product is 3:97.

[0179] The preparation method of the skin care product matrix is ​​as follows: 5 parts by weight of glycerin, 5 parts by weight of 1,3-propanediol, 1.5 parts by weight of emulsifier A165, 0.4 parts by weight of carbomer 941 and 88.1 parts by weight of deionized water are stirred at 50°C for 45 minutes and then naturally cooled to room temperature to obtain the product.

[0180] Human safety testing:

[0181] In accordance with the Cosmetic Safety Technical Specifications (2015 Edition), skin occlusive patch tests were conducted on the test samples and serums 1-3. Each group consisted of 40 subjects, the test dosage was 0.025g, and the test site was the back.

[0182] Table 1 Results of human safety tests

[0183] Group 30min 24h 48h Example 1 All were negative. All were negative. All were negative. Example 2 All were negative. All were negative. All were negative. Example 3 All were negative. All were negative. All were negative. Example 4 All were negative. All were negative. All were negative. Example 5 All were negative. All were negative. All were negative. Example 6 All were negative. All were negative. All were negative. Comparative Example 1 All were negative. All were negative. All were negative. Comparative Example 2 All were negative. All were negative. All were negative. Comparative Example 3 All were negative. All were negative. All were negative. Comparative Example 4 All were negative. All were negative. All were negative. Comparative Example 5 All were negative. All were negative. All were negative. Comparative Example 6 All were negative. All were negative. All were negative. Comparative Example 7 All were negative. All were negative. All were negative. Comparative Example 8 All were negative. All were negative. All were negative. Comparative Example 9 All were negative. All were negative. All were negative. Comparative Example 10 All were negative. All were negative. All were negative. Comparative Example 11 All were negative. All were negative. All were negative. Comparative Example 12 All were negative. All were negative. All were negative. Comparative Example 13 All were negative. All were negative. All were negative. Serum 1 All were negative. All were negative. All were negative. Serum 2 All were negative. All were negative. All were negative. Serum 3 All were negative. All were negative. All were negative.

[0184] Redness removal test:

[0185] Subject selection: 400 male or female volunteers with healthy skin aged 25-55 were recruited and randomly assigned to groups of 20.

[0186] Experimental Method: A 3cm × 3cm test area was marked on the inner forearm skin of the volunteers. The skin of the test area was peeled 10 times with transparent tape. Then, a 3cm × 3cm non-woven fabric soaked in a 10mg / mL histamine aqueous solution was applied. After 10 minutes, the non-woven fabric was removed. The skin in the test area was allowed to dry naturally until no solution residue remained before measuring the erythema index (EI) value (initial value). Subsequently, each group of volunteers applied the prepared test sample and blank sample respectively, with an application amount of 5mg / cm². 2 After 45 minutes, the erythema index (EI) value (soothing value) was retested. The ambient temperature during the entire test was 25°C and the relative humidity was 50%.

[0187] Results evaluation: Calculate the average of the initial value and the relief value for each group, round to the nearest integer, and calculate the difference between the two averages. The larger the difference, the better the redness reduction effect.

[0188] Table 2 Results of the redness removal test

[0189]

[0190]

[0191] Antipruritic test:

[0192] Subject selection: 220 healthy guinea pigs weighing 400-500g were selected. The hair on the back of the right hind foot of each guinea pig was shaved and the guinea pigs were randomly divided into groups of 10 each. One group was the model group, one group was the positive group, and the rest were the experimental group.

[0193] Experimental Methods: Drugs were administered to the shaved areas of each guinea pig. The model group received 0.9% saline solution, the positive control group received fluocinolone acetonide cream (Fuyuan Pharmaceutical Co., Ltd.), and the experimental groups received the prepared test sample and blank sample, respectively. The dosage for each group was 0.1 mL. 24 hours after administration, the shaved area was abraded with sandpaper to create a 1 cm × 1 cm wound. The corresponding drug administration was repeated once, with the dosage also being 0.1 mL. After 10 minutes, histamine phosphate aqueous solution was dripped onto the wounds of the guinea pigs. The dripping method was as follows: dripping once every 3 minutes, with each drip being 0.07 mL. The mass fraction of the histamine phosphate aqueous solution was 0.01% for the first drip, 0.02% for the second, 0.03% for the third, and so on.

[0194] Results evaluation: The experiment was stopped when the guinea pig turned its head to lick its right hind foot. The total mass of histamine phosphate used at this time was the itch threshold. The average itch threshold of each group was calculated, rounded to the nearest integer, and the antipruritic effect was evaluated.

[0195] Table 3 Results of the antipruritic test

[0196]

[0197]

[0198] As shown in Table 1, the plant composition prepared by this invention does not cause significant irritation to the human body, has high safety, and is suitable for application in the field of skin care products.

[0199] As shown in Table 2, the plant composition prepared by the present invention can exert the effect of reducing redness when applied to skin care products. Comparing the results of Example 1 and Comparative Example 1, it can be seen that the redness-reducing effect of the Atractylodes macrocephala-Andrographis paniculata extract extracted by the present invention using a low eutectic solvent is better than that of the Atractylodes macrocephala-Andrographis paniculata extract extracted by ultrasonic extraction with ethanol is better. Comparing the results of Example 1 and Comparative Examples 2-9, it can be seen that there is a significant synergistic effect among the raw materials in the plant composition of the present invention.

[0200] Comparing the results of Example 4 with those of Comparative Examples 10-13, it can be seen that the extracts of chamomile, forsythia root, peony root, ophiopogon root, scutellaria root, and the extract of atractylodes macrocephala-andrographis paniculata extracted by eutectic solvent in this invention have significant synergistic effects.

[0201] Comparing the results of Comparative Example 6 with those of Comparative Examples 2 and 7-8, it can be seen that the peony extract, ophiopogon extract, and atractylodes macrocephala-andrographis extract in this invention have a synergistic effect, but their efficacy is not as good as that of Composition 1 of this invention.

[0202] Comparing the results of Comparative Example 3 with those of Comparative Examples 7-9, it can be seen that there is a significant synergistic effect among the peony extract, ophiopogon extract and scutellaria extract in this invention, but their efficacy is not as good as that of composition 1 of this invention.

[0203] Comparing the results of Comparative Example 5 with those of Comparative Examples 2, 7, and 9, it can be seen that the extracts of Ophiopogon japonicus, Scutellaria baicalensis, and Atractylodes macrocephala-Andrographis paniculata extracted by eutectic solvent have a synergistic effect, but their efficacy is not as good as that of Composition 1 of the present invention.

[0204] Comparing the results of Comparative Example 4 with those of Comparative Examples 2 and 8-9, it can be seen that the extracts of Ophiopogon japonicus, Scutellaria baicalensis, and Atractylodes macrocephala-Andrographis paniculata extracted by eutectic solvent have a synergistic effect, but their efficacy is not as good as that of Composition 1 of the present invention.

[0205] As shown in Table 3, the plant composition prepared in this invention can also exert an antipruritic effect when applied to skin care products. Although the antipruritic effect cannot be compared with the positive group, it is significantly improved compared with comparative examples 1-13.

[0206] Preparation of an essence with anti-redness and anti-itch effects

[0207] Serum 1:

[0208] Includes the following components by mass percentage:

[0209] The plant composition in Example 1 was 10%;

[0210] 30 wt% glycerol;

[0211] Phenoxyethanol 0.5%;

[0212] Add deionized water to bring the solution to 100%.

[0213] Preparation method: Homogenize glycerol, phenoxyethanol, plant composition and deionized water for 3 min, fill into containers and seal for storage.

[0214] Serum 2:

[0215] Includes the following components by mass percentage:

[0216] The plant composition in Example 1 was 15%;

[0217] 25 wt% glycerol;

[0218] 1,2-Hexanediol 0.1%;

[0219] Add deionized water to bring the solution to 100%.

[0220] Preparation method: Homogenize glycerol, phenoxyethanol, plant composition and deionized water for 3 min, fill into containers and seal for storage.

[0221] Serum 3:

[0222] Includes the following components by mass percentage:

[0223] The plant composition in Example 1 was 5%.

[0224] 25 wt% glycerol;

[0225] Phenoxyethanol 0.1%;

[0226] 1,2-Hexanediol 1%

[0227] Add deionized water to bring the solution to 100%.

[0228] Preparation method: homogenize glycerol, phenoxyethanol, 1,2-hexanediol, plant composition and deionized water for 3 min, fill into a container and seal for storage.

[0229] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. A plant-based composition with anti-redness and antipruritic effects, characterized in that, The plant composition comprises the following mass parts of raw materials: Paeonia extract 8-12 parts; Ophiopogon extract 10-15 parts; Scutellaria extract 6-8 parts; Atractylodes powder 5-7 parts; Andrographis powder 3-5 parts; The preparation method of the plant composition comprises the following steps: (1) mixing Atractylodes powder and Andrographis powder which have passed through a 100-mesh sieve respectively according to the formula amount to obtain a mixed powder; (2) mixing the mixed powder with a eutectic solvent according to a solid-liquid ratio of 1:20-30 g / mL, and performing ultrasonic treatment under the conditions of an ultrasonic temperature of 50-60 DEG C and an ultrasonic power of 400-600 W for 30-40 min, and then centrifuging at 3000-5000 r / min for 10-20 min, and then taking the supernatant, and freeze-drying to obtain Atractylodes-Andrographis extract; (3) mixing Paeonia extract, Ophiopogon extract, Scutellaria extract and Atractylodes-Andrographis extract according to the formula amount to obtain a plant composition; The eutectic solvent is composed of a hydrogen bond acceptor, a hydrogen bond donor and deionized water, the molar ratio of the hydrogen bond acceptor, the hydrogen bond donor and the deionized water is 1:3-5:1.5-2.5, the hydrogen bond acceptor is choline chloride, and the hydrogen bond donor is 1,4-butanediol; the preparation steps of the eutectic solvent are as follows: mixing the hydrogen bond donor, the hydrogen bond acceptor and the deionized water, and then heating and stirring at 80-100 DEG C for 1-3 h to obtain the eutectic solvent.

2. The plant composition of claim 1, wherein, The plant composition comprises the following mass parts of raw materials: Paeonia extract 9-11 parts; Ophiopogon extract 11-13 parts; Scutellaria extract 6-7 parts; Atractylodes powder 6-7 parts; Andrographis powder 4-5 parts.

3. The plant composition of claim 1, wherein, The plant composition comprises the following mass parts of raw materials: Paeonia extract 10 parts; Ophiopogon extract 12 parts; Scutellaria extract 7 parts; Atractylodes powder 6 parts; Andrographis powder 5 parts.

4. Use of the plant composition according to any one of claims 1-3 in the preparation of a cosmetic product having the efficacy of relieving redness and itching.

5. The use according to claim 4, wherein the compound is ###0002### The cosmetic dosage form is selected from any one of serum, cream, eye cream and mask.

6. An essence having a redness-reducing and itching-relieving effect, characterized by, The serum comprises the following mass percentage components: The plant composition according to any one of claims 1-3 5-15%; Humectant 25-35%; Preservative 0.1-1%; Solvent to 100%.

7. The essence as described in claim 6, characterized in that, The humectant is glycerol.

8. The essence as described in claim 6, characterized in that, The preservative is phenoxyethanol and / or 1,2-hexanediol.

9. The essence as described in claim 6, characterized in that, The solvent is deionized water.

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