Medicinal and edible composition capable of warming and invigorating kidney yang and application of medicinal and edible composition

Abstract

The invention provides a medicinal and edible composition for warming and invigorating kidney yang and application thereof. The medicinal and edible composition is prepared from the following raw materials in parts by mass: 20 parts of Chinese wolfberry, 15 parts of burdock root, 15 parts of mulberry, 10 parts of rhizoma polygonati, 10 parts of poria cocos, 5 parts of cinnamon, 5 parts of raspberry, 5 parts of Chinese yam, 5 parts of liquorice, 5 parts of red ginseng, 1 part of fenugreek and 1 part of ginger. The medicinal and edible composition capable of warming and invigorating kidney yang can effectively relieve fatigue, nourish and strengthen body, tonify kidney and strengthen yang, invigorate spleen and replenish qi, and boost spirit, and can improve kidney-yang deficiency syndromes such as waist and knee pain, intolerance of cold and cold limbs, dizziness, lassitude, hyposexual desire and the like. The traditional Chinese medicines in the whole formula are medicinal and edible traditional Chinese medicines, are safe to eat, have remarkable effects, are stable and controllable in quality, and have remarkable economic and social benefits.

Description

Technical Field

[0001] The invention relates to a medicine-food homologous composition for warming and nourishing kidney yang and application thereof. Background Art

[0002] The kidneys are the "foundation of one's innate constitution," governing bones, storing essence, and producing marrow. The strength of the kidneys is directly related to a person's mental and physical strength. A strong kidney nourishes the brain, boosts spirits, and enhances vitality. However, many existing aphrodisiacs are Western medicines that fail to address the underlying cause and have limited kidney-tonifying effects. The Chinese medicines in this formula are both medicinal and edible, making them safer to consume than over-the-counter (OTC) medications.

[0003] The formula and preparation method are as follows: 20 parts wolfberry, 15 parts burdock root, 15 parts mulberry, 10 parts polygonatum, 10 parts poria, 5 parts cinnamon, 5 parts raspberry, 5 parts yam, 5 parts licorice, 5 parts red ginseng, 1 part fenugreek, and 1 part ginger. This product is simple to prepare and has remarkable efficacy. Cinnamon, fenugreek, and burdock root are the main herbs, known for their warming and kidney-tonifying properties, enhancing yang, replenishing essence and relieving atrophy, and strengthening tendons and bones. Wolfberry nourishes the liver and kidney yin, balancing kidney essence and liver blood. Polygonatum and yam replenish both spleen yin and yang, addressing significant kidney yang deficiency. Mulberry replenishes the liver and kidney yin. Ginger, known for its ability to restore yang and invigorate fire, serves as the auxiliary herb. Raspberry strengthens the kidneys, stops nocturnal emission, and astringes essence, stopping premature ejaculation. These six herbs enhance the effects of the main herbs and serve as the auxiliary herbs. Red ginseng and Poria cocos nourish the spleen and replenish qi, replenish the acquired foundation, and allow the medicine to lead the body's body fluids and qi to spread throughout the body, so that the body's mechanisms flow smoothly and the essence of water and grain is spread throughout the body, acting as adjuvants; licorice is used to harmonize yin and yang, harmonize the spleen and kidneys, harmonize tonification and purgation, and harmonize all medicines. Summary of the Invention

[0004] In order to solve the above technical problems, the purpose of the present invention is to provide a medicine-food composition for warming and nourishing kidney yang and its application, wherein the medicine-food composition for warming and nourishing kidney yang can effectively relieve fatigue, nourish and strengthen the body, nourish the kidney and strengthen yang, strengthen the spleen and replenish qi, and invigorate the spirit.

[0005] In order to achieve the above technical effects, the present invention adopts the following technical solutions: (1) In the first aspect, the present invention provides a medicinal and edible composition for warming and nourishing the kidney yang, wherein the medicinal and edible composition comprises the following medicinal raw material components: wolfberry, burdock root, mulberry, polygonatum, poria, cinnamon bark, raspberry, yam, liquorice, red ginseng, fenugreek, and ginger.

[0006] (2) Furthermore, the warming and tonifying kidney yang medicinal and edible composition comprises the following raw materials by weight: 20-22 parts of wolfberry, 15-18 parts of burdock root, 15-18 parts of mulberry, 10-13 parts of polygonatum, 10-13 parts of poria, 5-7 parts of cinnamon, 5-7 parts of raspberry, 5-7 parts of yam, 5-7 parts of liquorice, 5-7 parts of red ginseng, 1-3 parts of fenugreek, and 1-3 parts of ginger.

[0007] (3) Further, the medicated and edible composition for warming and tonifying kidney yang comprises the following medicinal raw materials in parts by mass: 20 parts of Chinese wolfberry, 15 parts of great burdock root, 15 parts of mulberry, 10 parts of polygonatum, 10 parts of poria, 5 parts of cinnamon, 5 parts of raspberry, 5 parts of Chinese yam, 5 parts of liquorice, 5 parts of red ginseng, 1 part of fenugreek, and 1 part of ginger.

[0008] (4) Further, the medicated and edible composition for warming yang and tonifying kidney also comprises food-acceptable excipients.

[0009] (5) Further, the medicated and edible composition for warming yang and tonifying kidney is prepared into any one of decoction, tablets, ointment, and granules.

[0010] (6) In the second aspect, the present invention also provides a preparation method of a medicated and edible composition for warming yang and tonifying kidney, comprising the following steps: S1: Weigh the medicinal raw materials according to the formula, pulverize them, decoct them 2 to 3 times, combine the medicinal liquids obtained from multiple decoctions, and cool them. S2: Concentrate the medicinal liquid obtained in S1 until a viscous near-ointment-like liquid is obtained, and then dry it.

[0011] (9) Further, in S2, the medicinal liquid is concentrated by a reduced-pressure concentration method, and the evaporation temperature is 40 to 42 °C, preferably 42 °C.

[0012] (10) Further, the reduced-pressure concentration is carried out by rotary evaporation with a rotary evaporator.

[0013] (11) Compared with the prior art, the beneficial effects of the present invention are as follows: In the first aspect, the medicated and edible composition for warming yang and tonifying kidney provided by the present invention is prepared from natural Chinese herbal medicines with medicated and edible homology, has a mild and lasting effect, will not cause severe irritation and harm to the body, has a mild action, and good safety.

[0014] In a second aspect, based on the traditional Chinese medicine (TCM) theory that "the kidney is in charge of storing essence", when formulating prescriptions and using herbs, this invention starts from the TCM concept of "kidney", warms the kidney yang, and rationally and effectively utilizes various herbs in this component, thereby achieving the effects of effectively relieving fatigue, nourishing and strengthening the body, tonifying the kidney and strengthening yang, invigorating the spleen and replenishing qi, and boosting the spirit. In the formula, cinnamon, fenugreek, and burdock root respectively tonify and warm the kidney yang, replenish essence and arouse impotence, and strengthen the muscles and bones, and together they serve as the sovereign herbs; wolfberry can nourish the yin of the liver and kidney, and is a herb for evenly tonifying the essence of the kidney and the blood of the liver; polygonatum and Chinese yam tonify both the yin and yang of the spleen, and there is a great deficiency of the true yang in the kidney; mulberry nourishes the yin of the liver and kidney; ginger can restore yang and strengthen fire, and together they serve as the ministerial herbs; raspberry consolidates the kidney and stops involuntary emissions, astringes sperm and stops leukorrhea, and the above six herbs can all enhance the effects of the sovereign herbs and together serve as the ministerial herbs of this formula. Red ginseng and poria strengthen the spleen and replenish qi, and supplement the acquired foundation. With the medicinal guide promoting the flow of qi and body fluid, the body's vital energy circulates smoothly, and the essence of food and water is distributed, serving as the assistant herbs; licorice is used to harmonize yin and yang, the spleen and kidney, tonification and purgation, and all the herbs, serving as the envoy herb. Although many of the herbs in this component have certain anti-fatigue effects when used alone, their effects are not significant when applied. In this formula, through reasonable compatibility of various herbs, their anti-fatigue effects are remarkable, and good anti-fatigue effects are achieved in animal experiments, greatly exerting the synergistic effects among various herbs and jointly achieving the effect of warming and tonifying the kidney yang.

[0015] (12) Verifying the effects through animal experiments: Select 60 adult male rats (body weight 30 - 35 g), in a clean metabolic cage with good ventilation (temperature 23 ± 2°C; photoperiod: 12 hours of natural light and 12 hours of darkness; humidity: 45 - 50%), randomly divided into 4 groups, with 15 rats in each group, respectively labeled as the blank group, low-dose group, medium-dose group, and high-dose group. Among them, the blank group is given pure water for administration, while the low-dose group, medium-dose group, and high-dose group are all; as the administration groups, they are continuously administered for four weeks. The above three administration groups are all given the decoction prepared in Example 1 as the administration drug. The above administration drug is respectively prepared into three administration doses of low, medium, and high, and the administration doses of the low-dose group, medium-dose group, and high-dose group are 3 g / kg, 4 g / kg, and 5 g / kg respectively.

[0016] 1) Effects on serum gonadotropin and testosterone levels The above three administration groups are continuously administered for four weeks with three administration doses of low, medium, and high respectively, and orally administered the drug and the medicine-food homologous composition for 28 consecutive days. 24 hours after the last extract gavage, serum samples, testes, and cauda epididymis are immediately taken for experimental evaluation. Compared with the blank group, this invention's medicine-food homologous composition (3 g / kg) caused significant differences in serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone levels at the three doses. Compared with the control group, the medicine-food homologous composition (3 g / kg) increased the levels of these hormones in the serum of rats. The relevant data are as Figure 1 ,Figure 2 , Figure 3 as shown.

[0017] 2) Effects on sperm count and motility The cauda epididymidis of mice was excited and cut into small pieces in 1.5 mL of 0.9% saline for sperm counting. Then, a drop of this sperm-containing solution was transferred to the chamber of a Neubauer hemocytometer, and sperm counting was manually monitored and counted in the white blood cell (WBC) chamber under an optical microscope (Olympus, Japan). In addition, sperm motility was evaluated by using 1% eosin staining for isolated unstained (live) and red-stained (dead) sperm. After maintaining 1% eosin in the WBC grid of the Neubauer hemocytometer for 30 seconds, sperm motility was manually counted within 2 minutes, and the data was expressed as a percentage.

[0018] The results showed that compared with the blank group, the extracts at three doses significantly increased the sperm count and motility of the animals, and the relevant data is as Figure 4 , Figure 5 shown.

[0019] The above experimental results indicate that a medicated diet homologous composition for warming and tonifying the kidney yang provided in this embodiment can regulate the levels of serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone, and significantly increase the sperm count and motility of animals. The results show that the application of the medicated diet homologous composition of the present invention has the effects of enhancing the sexual behavior of male rats and warming and tonifying the kidney yang.

[0020] The above embodiments are only used to illustrate the technical solutions of the present invention and not to limit them. Although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that the technical solutions of the present invention can be modified or equivalently replaced without departing from the purpose and scope of the technical solutions of the present invention, and they should all be covered within the scope of the claims of the present invention. The technologies, shapes, and structures not described in detail in the present invention are all well-known technologies. Description of the Drawings

[0021] Figure 1 Effects of the medicated diet homologous composition on serum luteinizing hormone (LH) Figure 2 Effects of the medicated diet homologous composition on follicle-stimulating hormone (FSH) Figure 3 Effects of the medicated diet homologous composition on serum testosterone Figure 4 Effects of the medicated diet homologous composition on sperm count Figure 5 Effects of the medicated diet homologous composition on sperm motility Specific Embodiments

[0022] The embodiments of the technical solution of the present invention will be described in detail below with reference to the accompanying drawings. The following embodiments are only used to illustrate the technical solution of the present invention more clearly, so they are only examples and cannot be used to limit the protection scope of the present invention. Embodiment 1

[0023] This embodiment is the first preparation embodiment of the present invention. This embodiment provides a yang-tonifying and kidney-tonifying composition of medicinals and foods homologous and its preparation method, which specifically includes: (1) In the first aspect, a yang-tonifying and kidney-tonifying composition of medicinals and foods homologous provided in this embodiment includes the following parts by mass of medicinal raw materials: 20 parts of wolfberry, 15 parts of burdock root, 15 parts of mulberry, 10 parts of polygonatum, 10 parts of poria cocos, 5 parts of cinnamon, 5 parts of raspberry, 5 parts of Chinese yam, 5 parts of licorice, 5 parts of red ginseng, 1 part of fenugreek, and 1 part of ginger.

[0024] (2) In the second aspect, a yang-tonifying and kidney-tonifying composition of medicinals and foods homologous provided in this embodiment is prepared into a decoction, and the preparation method is as follows: Weigh the medicinal raw materials according to the above parts by mass, crush them, soak them in deionized water with a volume 10 - 15 times that of the medicinal raw materials for half an hour, bring to a boil over high heat, then change to low heat and decoct for 30 minutes. After decocting, filter the medicinal residues with a gauze, pour the medicinal residues back into the pot and decoct again twice. When decocting for the second time, add deionized water with a volume 10 times that of the medicinal residues, bring to a boil over high heat, then change to low heat and decoct for 30 minutes, and take the filtrate; for the third decoction, add deionized water with a volume 8 times that of the medicinal residues, bring to a boil over high heat, then change to low heat and decoct for 30 minutes, filter and take the filtrate, and combine the filtrates obtained from the three decoctions to obtain a medicinal liquid, cool it to obtain a decoction. Embodiment 2

[0025] This embodiment is the second preparation embodiment of the present invention. This embodiment provides a yang-tonifying and kidney-tonifying composition of medicinals and foods homologous and its preparation method, which specifically includes: (1) In the first aspect, a yang-tonifying and kidney-tonifying composition of medicinals and foods homologous provided in this embodiment includes the following parts by mass of medicinal raw materials: 20 parts of wolfberry, 15 parts of burdock root, 15 parts of mulberry, 10 parts of polygonatum, 10 parts of poria cocos, 5 parts of cinnamon, 5 parts of raspberry, 5 parts of Chinese yam, 5 parts of licorice, 5 parts of red ginseng, 1 part of fenugreek, and 1 part of ginger.

[0026] (2) In the second aspect, a yang-tonifying and kidney-tonifying composition of medicinals and foods homologous provided in this embodiment is prepared into an ointment, and the preparation method is as follows: S1: Weigh the medicinal raw materials according to the above parts by mass, and prepare them into a decoction with reference to the method of Embodiment 1; S2: Further concentrate the decoction obtained in S1. The concentration is carried out by rotary evaporation under reduced pressure using a rotary evaporator. The specific operation is as follows: Pour the cooled liquid into the rotary evaporation flask in multiple batches, and the liquid poured each time should not exceed one-third of the total volume of the rotary evaporation flask. The rotary evaporation temperature is controlled at 42 °C, the rotation speed is adjusted to gear 4, the atmospheric pressure is first adjusted to 80 atmospheres, and the atmospheric pressure is reduced according to the situation after the rotary evaporation starts until it is concentrated into a viscous near-paste-like liquid. Pour the above-mentioned viscous near-paste-like liquid into a glassware and dry it in an oven until it becomes a paste, thus obtaining the paste preparation. Example 3

[0027] This example is the third preparation example of the present invention. This example provides a yang-tonifying and kidney-tonifying medicine and food homologous composition and its preparation method, which specifically includes: (1) On the first aspect, a yang-tonifying and kidney-tonifying medicine and food homologous composition provided in this example includes the following parts by mass of medicinal raw materials: 20 parts of wolfberry, 15 parts of burdock root, 15 parts of mulberry, 10 parts of polygonatum, 10 parts of poria, 5 parts of cinnamon, 5 parts of raspberry, 5 parts of Chinese yam, 5 parts of licorice, 5 parts of red ginseng, 1 part of fenugreek, and 1 part of ginger.

[0028] (2) On the second aspect, a yang-tonifying and kidney-tonifying medicine and food homologous composition provided in this example is prepared into tablets, and the preparation method is as follows: S1: Weigh the medicinal raw materials according to the above parts by mass, 20 parts of wolfberry, 15 parts of burdock root, 15 parts of mulberry, 10 parts of polygonatum, 10 parts of poria, 5 parts of cinnamon, 5 parts of raspberry, 5 parts of Chinese yam, 5 parts of licorice, 5 parts of red ginseng, 1 part of fenugreek, and 1 part of ginger. Before extraction, first soak the medicinal raw materials with 1 - 3 times of water, and then extract with 8 - 9 times of water. The percolation extraction flow rate is controlled at 4 - 5 ml / min, and the extract is obtained after the extraction is completed; S2: Further carry out rotary evaporation under reduced pressure on the extract obtained in S1 using a rotary evaporator to obtain a viscous near-paste-like liquid, and add excipients including fillers and lubricants to the above-mentioned viscous near-paste-like liquid, and then prepare it into tablets by wet granulation. Among them, the above-mentioned fillers and lubricants can be selected from the prior art. Example 4

[0029] This example is the third preparation example of the present invention. This example provides a yang-tonifying and kidney-tonifying medicine and food homologous composition and its preparation method, which specifically includes: (1) On the first aspect, a yang-tonifying and kidney-tonifying medicine and food homologous composition provided in this example includes the following parts by mass of medicinal raw materials: 20 parts of wolfberry, 15 parts of burdock root, 15 parts of mulberry, 10 parts of polygonatum, 10 parts of poria, 5 parts of cinnamon, 5 parts of raspberry, 5 parts of Chinese yam, 5 parts of licorice, 5 parts of red ginseng, 1 part of fenugreek, and 1 part of ginger.

[0030] (2)In the second aspect, a yang-warming and kidney-tonifying medicated and edible homologous composition provided in this embodiment is prepared into granules, and the preparation method is as follows: S1: Weigh the drug raw materials according to the above parts by mass, including 20 parts of wolfberry, 15 parts of burdock root, 15 parts of mulberry, 10 parts of polygonatum, 10 parts of poria cocos, 5 parts of cinnamon, 5 parts of raspberry, 5 parts of Chinese yam, 5 parts of licorice, 5 parts of red ginseng, 1 part of fenugreek, and 1 part of ginger. Before extraction, soak the drug raw materials with a solvent with a volume of 1 - 3 times, and then extract with a solvent with a volume of 8 - 9 times. Control the percolation extraction flow rate at 4 - 5 ml / min to obtain an extract after extraction is completed; S2: Further perform reduced-pressure rotary evaporation on the extract obtained in S1 by a rotary evaporator to obtain a viscous near-paste-like liquid, add excipients to the above viscous near-paste-like liquid, and then prepare it into granules by wet granulation.

Claims

1. A medicine-food homologous composition for warming and tonifying kidney yang, characterized in that, It includes the following pharmaceutical raw material components: wolfberry, burdock root, mulberry, polygonatum, poria, cinnamon, raspberry, Chinese yam, licorice, red ginseng, fenugreek, and ginger.

2. The medicated and edible homologous composition for warming and tonifying kidney yang as claimed in claim 1, wherein It includes the following parts by mass of pharmaceutical raw materials: 20 - 22 parts of wolfberry, 15 - 18 parts of burdock root, 15 - 18 parts of mulberry, 10 - 13 parts of polygonatum, 10 - 13 parts of poria, 5 - 7 parts of cinnamon, 5 - 7 parts of raspberry, 5 - 7 parts of Chinese yam, 5 - 7 parts of licorice, 5 - 7 parts of red ginseng, 1 - 3 parts of fenugreek, and 1 - 3 parts of ginger.

3. The medicated and edible homologous composition for warming and tonifying kidney yang as described in claim 1, wherein It includes the following parts of pharmaceutical raw materials: 20 parts of wolfberry, 15 parts of burdock root, 15 parts of mulberry, 10 parts of polygonatum, 10 parts of poria, 5 parts of cinnamon, 5 parts of raspberry, 5 parts of Chinese yam, 5 parts of licorice, 5 parts of red ginseng, 1 part of fenugreek, and 1 part of ginger.

4. A homologous composition of medicine and food for warming and tonifying kidney yang as described in any one of claims 1 to 3, characterized in that, The medicated and food homologous composition for warming and tonifying the kidney yang further includes food - acceptable excipients.

5. A traditional Chinese medicine and food homologous composition for warming and tonifying kidney yang as described in any one of claims 1 to 3, characterized in that: The medicated and food homologous composition for warming and tonifying the kidney yang is prepared into any one of decoction, tablets, ointments, powders, and granules.

6. Use of a medicated and food homologous composition for warming and tonifying the kidney yang according to any one of claims 1 - 3 in the preparation of foods, health products, or medicines for warming and tonifying the kidney yang.

7. Use of a medicated and food homologous composition for warming and tonifying the kidney yang according to any one of claims 1 - 3 in the preparation of foods for preventing and treating kidney yang deficiency.

8. The preparation method of a composition of medicine and food homologous for warming and tonifying kidney yang according to any one of claims 1 to 3, characterized in that, It includes the following steps: S1: Weigh the pharmaceutical raw materials according to the formula, crush them, and then decoct for 2 - 3 times. Combine the medicinal liquids obtained from multiple decoctions and cool them. S2: Concentrate the medicinal liquid obtained in S1 until a viscous near - paste - like liquid is obtained, and then dry it.

9. The preparation method of a composition of medicated diet for warming and tonifying kidney yang as claimed in claim 8, characterized in that, In S2, the medicinal liquid is concentrated by a vacuum concentration method, and the evaporation temperature is 40 - 42 °C.

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