A composition for treating acne and excess oil in adolescents and its use

Abstract

The present application relates to the cosmetic technical field, specifically to a kind of composition for controlling oil and acne of adolescent and application thereof.The fig extract in the composition of the present application has the effect of oil control, soothing and anti-inflammatory, the European water oak bud extract can effectively reduce sebum secretion and inhibit the expression of inflammatory factors, the red ganoderma extract contains rich triterpenoid compounds and polysaccharide compounds, which can effectively regulate skin health and enhance skin barrier function.The above three substances are used in combination, and have significant oil control and root acne-removing effects.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of cosmetics, in particular to a composition for controlling oil and acne, and application thereof. BACKGROUND

[0002] The adolescent group often faces problems such as frequent acne, large pores and oily skin due to fluctuations in the levels of various hormones in the body, hyperfunction of sebaceous glands and abnormal keratinization of hair follicles. Traditional oil-controlling and acne-removing products often use single active ingredients (such as salicylic acid, benzoyl peroxide or antibiotics) to solve a certain aspect (such as exfoliating keratin, killing propionibacterium acnes or inhibiting inflammation), but there are three major defects: first, excessive attention is paid to the regulation of sebum secretion while the balance of skin microecology is ignored, leading to the breeding of drug-resistant strains of propionibacterium acnes and the disorder of skin flora diversity; second, the simple reliance on keratin exfoliating ingredients easily damages the natural barrier function of the skin, aggravating transdermal water loss and sensitivity risk; third, long-term use of chemically synthesized ingredients may cause skin irritation or systemic side effects, especially for the adolescent group in the skin barrier development stage of puberty. Studies have shown that the occurrence of acne is not only a local microbial infection problem, but also a complex pathological process involving multiple factors such as metabolic disorder of hair follicle sebaceous gland units, immune microenvironment disorder and damage to the physical barrier. Recent studies have pointed out that mechanisms such as excessive proliferation of hair follicle duct epithelial cells, abnormal composition of sebaceous gland lipids (such as imbalance in the proportion of free fatty acids), Th17 / Treg cell immune imbalance and abnormal expression of antibacterial peptide LL-37 are involved in the progression of acne. Therefore, there is an urgent need to develop a new composite formula that can simultaneously regulate sebum metabolism and root out acne. SUMMARY

[0003] The present application is based on the solution to the above technical problems, and provides a composition for controlling oil and acne for adolescents and application thereof.

[0004] The composition for controlling oil and acne for adolescents provided by the present application comprises the following raw materials: ficus carica fruit extract, ulex europaeus sprout extract and ganoderma lucidum extract.

[0005] In a first aspect, the present application provides a composition for controlling oil and acne for adolescents, which comprises the following raw materials in parts by mass: ficus carica fruit extract 0.1-5 parts, ulex europaeus sprout extract 0.3-3.7 parts and ganoderma lucidum extract 0.6-3.4 parts.

[0006] Further, the composition for controlling oil and acne comprises the following raw materials in parts by mass: ficus carica fruit extract 2-4 parts, ulex europaeus sprout extract 1-3 parts and ganoderma lucidum extract 1-3 parts.

[0007] Further, the oil-control and acne-removing composition comprises the following raw materials in mass parts: Ficus carica fruit extract 3 parts, Quercus robur bud extract 2 parts, Ganoderma lucidum extract 2 parts.

[0008] Preferably, the preparation of the Ganoderma lucidum extract comprises the following steps:

[0009] S1: mixing Ganoderma lucidum powder with 3-5 times mass of 60wt% ethanol-water solution, refluxing extraction at 60±5℃ for 2-3h, filtering to obtain filtrate A and residue A;

[0010] S2: adding 2-4 times volume of anhydrous ethanol to the filtrate A, centrifuging to collect solid A and supernatant A;

[0011] S3: performing vacuum distillation on the supernatant A to remove ethanol, freeze-drying to obtain product one;

[0012] S4: mixing the residue A and the solid A, adding 3-5 times mass of deionized water, ultrasonic oscillation for 1-2h, filtering to obtain filtrate B, dialyzing the filtrate B using a cellulose dialysis bag with a solution cutoff molecular weight of 10-50kDa, freeze-drying the solution to obtain product two; wherein the ultrasonic oscillation frequency is 40-50kHz and the temperature is 25±2℃;

[0013] S5: mixing the product one and the product two at a mass ratio of 1:0.6-0.8 to obtain the Ganoderma lucidum extract.

[0014] In a second aspect, the present application provides a use of the oil-control and acne-removing composition for teenagers as described in the first aspect in the preparation of an oil-control and acne-removing cosmetic for teenagers.

[0015] Further, the dosage form of the cosmetic is any one of cream, milk, essence, and mask.

[0016] In a third aspect, the present application provides an oil-control and acne-removing essence for teenagers, which comprises the following components in mass percentage:

[0017] 0.001-3% of the oil-control and acne-removing composition as described in the first aspect;

[0018] 0.5-15% of a humectant;

[0019] 0.1-5% of a thickening agent;

[0020] 0.1-1% of an antioxidant;

[0021] 0.01-0.1% of a chelating agent;

[0022] deionized water is supplemented to 100%.

[0023] Further, the humectant comprises at least one of butylene glycol, 1,2-hexanediol, and 1,2-pentanediol; the thickening agent comprises xanthan gum or arthrobotry gum; the antioxidant comprises p-hydroxyacetophenone or vitamin C; and the chelating agent comprises disodium EDTA.

[0024] Further, the preparation method of the essence comprises the following steps:

[0025] Step A: uniformly mixing the humectant, the thickening agent, the antioxidant, the chelating agent, and deionized water to obtain a mixture;

[0026] Step B: uniformly mixing the mixture with the oil-controlling and acne-removing composition to obtain the essence.

[0027] Further, the mixing temperature in Step A is 70-90 DEG C, and the mixing temperature in Step B is 30-45 DEG C.

[0028] Beneficial effects:

[0029] The composition of the present application realizes four-dimensional intervention of "metabolism-keratinization-immunity-barrier" through the multidimensional synergistic regulation mechanism of ficus carica fruit extract, acer saccharum bud extract, and ganoderma lucidum extract: the ficus carica fruit extract can regulate sebum secretion by inhibiting the activity of key enzymes in lipid synthesis and the androgen receptor signaling pathway, the acer saccharum bud extract can improve abnormal keratinization of hair follicles by blocking the activity of cell cycle kinases and regulating the keratin expression network, and the ganoderma lucidum extract can strengthen the skin immune barrier by inhibiting the pathogen metabolism-related immune pathway; the three components synergistically significantly reduce the activity of SZ95 sebaceous gland cells, and the reduction rate of sebum secretion is as high as 27.44% after 4 weeks of actual measurement in human body, and no irritation reaction occurs, thus breaking through the limitations of traditional single target intervention and providing a safe and efficient new strategy for root acne and acne treatment. DETAILED DESCRIPTION

[0030] The present application will be described below in conjunction with the specific embodiments, and various effects of the present application will thus be more clearly presented. Those skilled in the art should understand that these specific embodiments are used to illustrate the present application, rather than limit the present application.

[0031] Unless otherwise specifically stated, various raw materials, reagents, instruments, and equipment used in the present application can be purchased from the market or can be prepared by existing methods.

[0032] In the specific embodiments of the present application, the sources of raw materials are as follows:

[0033] Ficus carica fruit extract: purchased from Hangzhou Shiguang Xinya Biotechnology Co., Ltd.;

[0034] Acer saccharum bud extract: purchased from Jafar Lion Company;

[0035] Ganoderma lucidum powder: purchased from Guangdong Microbial Technology Co., Ltd.

[0036] Composition formula for acne treatment and preparation thereof

[0037] The composition formula is measured by mass parts.

[0038] Composition 1:

[0039] Fig extract 3 parts, European blue oak bud extract 2 parts, Ganoderma lucidum extract 2 parts;

[0040] The Ganoderma lucidum extract is prepared by the following preparation method:

[0041] S1: Mix Ganoderma lucidum powder with 5 times the mass of 60wt% ethanol-water solution, reflux extraction at 60℃ for 2.5h, filter to obtain filtrate A and residue A;

[0042] S2: Add 4 times the volume of anhydrous ethanol to the filtrate A, centrifuge, and collect solid A and supernatant A;

[0043] S3: Distill the supernatant A under reduced pressure to remove ethanol, and freeze-dry to obtain product one;

[0044] S4: Mix the residue A and the solid A, add 5 times the mass of deionized water, ultrasonic oscillation for 1h, filter to obtain filtrate B, dialyze the filtrate B, use cellulose dialysis bag to cut off the solution with a molecular weight of 10-50kDa, and freeze-dry the solution to obtain product two; wherein the ultrasonic oscillation frequency is 45kHz and the temperature is 25℃;

[0045] S5: Mix product one and product two according to the mass ratio of 1:0.7 to obtain Ganoderma lucidum extract.

[0046] Composition 2:

[0047] Fig extract 2 parts, European blue oak bud extract 3 parts, Ganoderma lucidum extract 1 part;

[0048] The Ganoderma lucidum extract is prepared by the following preparation method:

[0049] S1: Mix Ganoderma lucidum powder with 5 times the mass of 60wt% ethanol-water solution, reflux extraction at 60℃ for 2.5h, filter to obtain filtrate A and residue A;

[0050] S2: Add 4 times the volume of anhydrous ethanol to the filtrate A, centrifuge, and collect solid A and supernatant A;

[0051] S3: Distill the supernatant A under reduced pressure to remove ethanol, and freeze-dry to obtain product one;

[0052] S4: The filter residue A is mixed with the solid A, 4 times the mass of deionized water is added, ultrasonic oscillation is carried out for 1.5 h, filtration is carried out, filter liquor B is obtained, the filter liquor B is dialyzed, a cellulose dialysis bag is used to cut off the solution with a molecular weight of 10-50 kDa, the solution is freeze-dried, and product two is obtained; wherein the frequency of the ultrasonic oscillation is 40 kHz, and the temperature is 27°C;

[0053] S5: The product one and the product two are mixed in a mass ratio of 1:0.6 to obtain the Ganoderma lucidum extract.

[0054] Composition 3:

[0055] 4 parts of fig fruit extract, 1 part of European oak sprout extract, and 3 parts of Ganoderma lucidum extract;

[0056] The Ganoderma lucidum extract is prepared by the following preparation method:

[0057] S1: The Ganoderma lucidum powder is mixed with 3 times the mass of 60wt% ethanol-water solution, reflux extraction is carried out at 55°C for 3 h, filtration is carried out, and filter liquor A and filter residue A are obtained;

[0058] S2: 2 times the volume of anhydrous ethanol is added to the filter liquor A, centrifugation is carried out, and the solid A and the supernatant A are collected;

[0059] S3: The supernatant A is subjected to vacuum distillation to remove ethanol, and freeze-drying is carried out to obtain product one;

[0060] S4: The filter residue A is mixed with the solid A, 3 times the mass of deionized water is added, ultrasonic oscillation is carried out for 2 h, filtration is carried out, filter liquor B is obtained, the filter liquor B is dialyzed, a cellulose dialysis bag is used to cut off the solution with a molecular weight of 10-50 kDa, the solution is freeze-dried, and product two is obtained; wherein the frequency of the ultrasonic oscillation is 50 kHz, and the temperature is 23°C;

[0061] S5: The product one and the product two are mixed in a mass ratio of 1:0.8 to obtain the Ganoderma lucidum extract.

[0062] Composition ①:

[0063] Different from the composition 1, the fig fruit extract is absent, and the missing mass parts are supplemented with deionized water.

[0064] Composition ②:

[0065] Different from the composition 1, the European oak sprout extract is absent, and the missing mass parts are supplemented with deionized water.

[0066] Composition ③:

[0067] Different from the composition 1, the Ganoderma lucidum extract is absent, and the missing mass parts are supplemented with deionized water.

[0068] Composition ④:

[0069] Different from composition 1, the extract of European blue beech sprout and the extract of red mushroom are absent, and the missing mass parts are made up with deionized water.

[0070] Composition ⑤:

[0071] Different from composition 1, the extract of European blue beech sprout and the extract of red mushroom are absent, and the missing mass parts are made up with deionized water.

[0072] Composition ⑥:

[0073] Different from composition 1, the extract of European blue beech sprout and the extract of red mushroom are absent, and the missing mass parts are made up with deionized water.

[0074] Composition ⑦:

[0075] Different from composition 1, the step S2 is not included in the preparation of the extract of red mushroom, and the specific preparation steps of the extract of red mushroom are as follows:

[0076] S1: mix the red mushroom powder with 5 times the mass of 60wt% ethanol-water solution, reflux extraction at 60℃ for 2.5h, filter to obtain filtrate A and residue A;

[0077] S2: distill filtrate A under reduced pressure to remove ethanol, freeze-dry to obtain product one;

[0078] S3: add 5 times the mass of deionized water to residue A, ultrasonic oscillation for 1h, filter to obtain filtrate B, dialyze filtrate B, use cellulose dialysis bag to cut off the solution with a molecular weight of 10-50kDa, freeze-dry the solution to obtain product two; the ultrasonic oscillation frequency is 45kHz, and the ultrasonic temperature is 25℃;

[0079] S4: mix product one and product two according to the mass ratio of 1:0.7 to obtain the extract of red mushroom.

[0080] Composition ⑧:

[0081] Different from composition 1, the dialysis step S2 is not included in the preparation of the extract of red mushroom, and the specific preparation steps of the extract of red mushroom are as follows:

[0082] S1: mix the red mushroom powder with 5 times the mass of 60wt% ethanol-water solution, reflux extraction at 60℃ for 2.5h, filter to obtain filtrate A and residue A;

[0083] S2: add 4 times the volume of anhydrous ethanol to filtrate A, centrifuge to collect solid A and supernatant A;

[0084] S3: distill supernatant A under reduced pressure to remove ethanol, freeze-dry to obtain product one;

[0085] S4: The filter residue A was mixed with solid A, 5 times the mass of deionized water was added, ultrasonic oscillation was performed for 1 h, filtration was performed, and filter liquor B was obtained. The filter liquor B was subjected to freeze-drying to obtain product two; wherein the ultrasonic oscillation was performed at a frequency of 45 kHz and a temperature of 25°C.

[0086] S5: Product one and product two were mixed at a mass ratio of 1:0.7 to obtain the Ganoderma lucidum extract.

[0087] Composition ⑨:

[0088] Different from composition 1, in the preparation of the Ganoderma lucidum extract, a cellulose dialysis bag was used to intercept a solution with a molecular weight of 0-10 kDa, and the remaining steps and parameters were the same as those of composition 1.

[0089] Composition ⑩:

[0090] Different from composition 1, in the preparation of the Ganoderma lucidum extract, a cellulose dialysis bag was used to intercept a solution with a molecular weight of >50 kDa, and the remaining steps and parameters were the same as those of composition 1.

[0091] Performance test

[0092] Composition oil control experiment

[0093] Test principle: Human sebaceous gland cells are the main place of androgen synthesis and metabolism in the skin, and also the cells with the highest androgen receptor content in the skin. Androgens have been confirmed to stimulate the differentiation of sebaceous gland cells, and an increase in the content of androgens can cause an increase in sebum secretion. This test evaluates the oil control effect of the composition by comparing the effect of the test sample (composition) and the Model group (DMEM culture medium) on the viability of human sebaceous gland cells SZ95.

[0094] Test method:

[0095] This method is an in vitro method suitable for cosmetics claiming oil control effect. The trend of limiting in vivo methods in relevant literature materials has a certain relevance to this in vitro method. Through test design, the SZ95 cell OD value results of the test sample and the Model (model group) are compared. If the SZ95 cell OD value of the test sample group is lower than that of the Model and the statistical difference P value is <0.05, it can be considered that the test sample has a certain oil control effect.

[0096] Main instruments: incubator, clean bench, microplate reader, pipette;

[0097] Main reagents: DMEM culture medium, 5α-dihydrotestosterone, 0.25wt% trypsin, PBS, CCK-8.

[0098] Test sample: compositions 1-3, compositions ①-⑩.

[0099] Preparation of test sample: the test sample is prepared into 1.7wt% mixture using DMEM medium, and is prepared immediately before use.

[0100] Test procedure:

[0101] 1. Human sebaceous gland cells SZ95 are inoculated into DMEM medium, and then 100μL of 10μM 5α-dihydrotestosterone is added for culture for 72h.

[0102] 2. After the end of culture, the cells are digested using 0.25wt% trypsin, and are inoculated into 96-well plates at 5×10 3 cells / well, and are cultured for 24h.

[0103] 3. After the end of culture, the supernatant is discarded, 100μL of test sample is added, and the Model group is added with an equal amount of medium, and is continuously cultured for 24h.

[0104] 4. After the end of culture, the supernatant is discarded, and is washed twice using PBS, 100μL of medium containing 10v / v% CCK-8 is added to each well, and is incubated for 2.5h, and the cell viability is detected.

[0105] Each group of samples has 3 parallels, and the test results (average value ± standard deviation) are shown in Table 1.

[0106] Table 1: Effect of composition on SZ95 cell viability

[0107] Group OD value Model 0.436±0.05 Composition 1 0.193±0.02* Composition 2 0.197±0.02* Composition 3 0.195±0.07* Composition 1 0.289±0.14* Composition 2 0.269±0.11* Composition 3 0.331±0.09* Composition 4 0.376±0.06* Composition 5 0.394±0.07* Composition 6 0.337±0.04* Composition 7 0.217±0.09* Composition 8 0.225±0.14* Composition 9 0.237±0.11* Composition 10 0.252±0.13*

[0108] Note: "*" indicates that P value < 0.05 compared with Model.

[0109] The present test observes the oil control effect of compositions 1-3 by comparing the effect of Model and the composition on the viability of SZ95 cells, and the results show that compositions 1-3 have the effect of inhibiting the proliferation of SZ95 cells, indicating that the composition has the oil control effect.

[0110] It can be known from the comparison of composition 1 and compositions ①-⑥ that the ficus carica fruit extract, the euonymus europaeus bud extract and the ganoderma lucidum extract in the present application have significant synergistic effect, and the three together can significantly improve the proliferation inhibition effect on SZ95 cells.

[0111] It can be known from the comparison of composition 1 and compositions ⑦-⑩ that the ganoderma lucidum extract extracted by the preparation method of the ganoderma lucidum extract defined in the present application has better effect in the composition system provided by the present application.

[0112] Propionibacterium acnes inhibition test

[0113] Test Purpose: Propionibacterium acnes is the main bacteria in acne, which affects the healing of acne. In this test, the growth inhibition of Propionibacterium acnes by the composition and Control (deionized water) is compared to evaluate the acne-removing effect of the composition.

[0114] Test Method Relevance

[0115] This method is an in vitro method using cosmetics claimed to have acne-removing effect. Literature shows that the trend of in vivo method has certain relevance to this in vitro method. Through test design, the test sample (composition) and Control (blank control group) are compared in terms of Propionibacterium acnes inhibition zone diameter. If the inhibition zone diameter of the test sample group is larger than that of the Control, it is considered that the test sample has certain acne-removing effect.

[0116] Test Method:

[0117] Main Instruments: incubator, clean bench, pipette, high-pressure steam sterilization pot, 6mm puncher.

[0118] Main Reagents: thioglycolate medium, agar powder.

[0119] Test Sample: Composition 1-3, Composition ①-⑩;

[0120] Test Sample Preparation: The test sample is prepared into a 1.7wt% mixture using deionized water solution, and is prepared as needed.

[0121] Control Sample: Deionized water.

[0122] Test Steps:

[0123] 1) Propionibacterium acnes is inoculated into thioglycolate liquid medium and cultured in a constant-temperature anaerobic incubator at 30℃ for 48h to obtain a Propionibacterium acnes suspension, wherein the concentration of Propionibacterium acnes in the Propionibacterium acnes suspension is 10 6 individuals / mL.

[0124] 2) Now pour thioglycolate medium containing 1.5wt% agar powder into a plate, and after solidification, use it as the lower plate. Then use a pipette to suck 500μL of Propionibacterium acnes suspension into 5mL of thioglycolate medium containing 0.7wt% agar powder cooled to 40℃, mix well, and pour into the lower plate. After it is completely solidified, use a puncher to punch the upper plate, and then add 100μL of test sample or Control to the punched hole. Place the plate in a 37℃ incubator for 48h, and then use a vernier caliper to measure the inhibition zone. Each group of experiments has 3 replicates, and the inhibition zone diameter is expressed as an average value. The test results are shown in Table 2.

[0125] Table 2 Inhibition effect of the compositions on Propionibacterium acnes

[0126] Group Inhibition zone diameter / mm Control - Composition 1 26.56 Composition 2 24.37 Composition 3 26.15 Composition 1 13.44 Composition 2 16.53 Composition 3 11.32 Composition 4 4.33 Composition 5 4.51 Composition 6 7.62 Composition 7 23.74 Composition 8 24.73 Composition 9 23.21 Composition 10 21.96

[0127] Note: "-" represents no inhibition zone.

[0128] From the comparison of the inhibition effects of the compositions 1-3, the compositions 1-9, and the control on Propionibacterium acnes, it can be seen that the compositions 1-3 have significant bacteriostatic effects, and the test shows that the compositions provided by the application have acne-removing effects.

[0129] From the comparison of the compositions 1 and the compositions 1-6, it can be seen that the Ficus carica fruit extract, the Fagus sylvatica bud extract, and the Ganoderma lucidum extract in the application have significant synergistic effects.

[0130] From the comparison of the compositions 1 and the compositions 7-9, it can be seen that the Ganoderma lucidum extract extracted by the preparation method defined in the application has better effects in the composition system provided by the application.

[0131] Human efficacy test

[0132] Test subjects: 130 subjects with mixed or oily skin and mild or moderate acne were randomly selected, aged 18-30 years.

[0133] Test samples: serum 1-3, serum 1-9;

[0134] Test sample preparation: the serum includes 1.7wt% of the oil-controlling acne-removing composition, 10wt% of a humectant, 1wt% of a thickening agent, 0.5wt% of an antioxidant, and 0.05wt% of a chelating agent, and deionized water is used to supplement to 100wt%; the humectant is butylene glycol, the thickening agent is sordarium gum, the antioxidant is hydroxyacetophenone, and the chelating agent is EDTA-disodium; the test sample preparation method is as follows:

[0135] Step A: uniformly mix the humectant, the thickening agent, the antioxidant, the chelating agent, and the deionized water at 80°C to obtain a mixture;

[0136] Step B: uniformly mix the mixture and the oil-controlling acne-removing composition at 40°C to obtain the serum.

[0137] The oil-controlling acne-removing compositions in the serum 1-3 and 1-9 correspond to the compositions 1-3 and 1-9, respectively.

[0138] Test site: face, using self-control method, and recording the samples used by each subject.

[0139] Test method: the subjects were randomly divided into 13 groups, 10 people in each group, each group corresponding to one sample, after cleaning the face, 1g of the essence was used on the test site, and it was absorbed by massage, once in the morning and evening, for 4 weeks. The skin oil test probe was used to measure the oil content of the face of the subjects, and the test was conducted 3 times before and after the test to take the average value. On the first day of the test, before the first application of the essence, the volunteers were tested for satisfaction (1-10 points) after the test, and then the average satisfaction of each group was obtained, and the satisfaction trend was: good effect (8-10 points) > better effect (7-7.9 points) > general effect (6-6.9 points) > poor effect (4-5.9 points) > no obvious effect (2-3.9 points) > no effect (<2 points).

[0140] Oil secretion reduction rate = (measurement value before the test begins - measurement value after the test ends) / measurement value before the test begins

[0141] The test results are represented by the average value of the oil secretion reduction rate of each group, which is shown in Table 3.

[0142] Table 3 Human efficacy test

[0143] Group Sebum secretion reduction rate (%) Volunteer satisfaction Serum 1 27.44 Good effect Serum 2 25.37 Good effect Serum 3 26.63 Good effect Serum 1 16.72 Average effect Serum 2 17.21 Average effect Serum 3 10.33 Average effect Serum 4 3.96 Poor effect Serum 5 1.57 No obvious effect Serum 6 6.44 Poor effect Serum 7 20.37 Good effect Serum 8 23.39 Good effect Serum 9 22.52 Good effect Serum 10 21.21 Good effect Serum 11 Good effect

[0144] According to the results of the human efficacy test, it can be known that the essence 1-3 and the essence 1-3 in the present application have certain effects of reducing facial oil secretion.

[0145] Those skilled in the art can make various modifications and variations to the present application without departing from the spirit and scope of the present application. Thus, if these modifications and variations of the present application fall within the scope of the claims of the present application and their equivalents, the present application also intends to include these modifications and variations.

Claims

1. A composition for controlling oil and acne in adolescents, characterized in that, The oil-control and acne-removing composition comprises the following raw materials in parts by mass: Ficus carica fruit extract 2-4 parts, Fagus sylvatica bud extract 1-3 parts, Ganoderma lucidum extract 1-3 parts; The preparation of the Ganoderma lucidum extract comprises the following steps: S1: mixing Ganoderma lucidum powder with 3-5 times mass of 60wt% ethanol-water solution, refluxing extraction at 60±5℃ for 2-3h, filtering to obtain filtrate A and residue A; S2: adding 2-4 times volume of anhydrous ethanol to the filtrate A, centrifuging to collect solid A and supernatant A; S3: removing ethanol from the supernatant A by vacuum distillation, freeze-drying to obtain product one; S4: mixing the residue A and the solid A, adding 3-5 times mass of deionized water, ultrasonic oscillation at 40-50kHz and 25±2℃ for 1-2h, filtering to obtain filtrate B, dialyzing the filtrate B using a cellulose dialysis bag with a molecular weight cut-off of 10-50kDa, freeze-drying the solution to obtain product two; S5: mixing the product one and the product two at a mass ratio of 1:0.6-0.8 to obtain the Ganoderma lucidum extract.

2. The composition according to claim 1, wherein The oil-control and acne-removing composition comprises the following raw materials in parts by mass: Ficus carica fruit extract 3 parts, Fagus sylvatica bud extract 2 parts, Ganoderma lucidum extract 2 parts.

3. Use of the oil-control and acne-removing composition for teenagers in any one of claims 1-2 in the preparation of a cosmetic product for teenagers.

4. Use according to claim 3, characterized in that, The dosage form of the cosmetic product is any one of cream, lotion, serum, and mask.

5. A youth research oil-control acne-removing serum water, characterized in that, The serum comprises the following components in percentage by mass: The oil-control and acne-removing composition for teenagers in any one of claims 1-2 1.7-3%; Humectant 0.5-15%; Thickening agent 0.1-5%; Antioxidant 0.1-1%; Chelating agent 0.01-0.1%; Deionized water to 100%. The humectant includes at least one of butylene glycol, 1,2-hexanediol, and 1,2-pentanediol; the thickening agent includes xanthan gum or sordariomycete gum; the antioxidant includes p-hydroxyacetophenone or vitamin C; and the chelating agent includes disodium EDTA.

6. The serum of claim 5, wherein the serum is characterized by, The preparation method of the serum comprises the following steps:

7. The serum according to claim 5 or 6, characterized in that, Step A: mixing the humectant, the thickening agent, the antioxidant, the chelating agent, and the deionized water uniformly to obtain a mixture; Step B: mixing the mixture with the oil-control and acne-removing composition uniformly to obtain the serum; The mixing temperature in step A is 70-90℃, and the mixing temperature in step B is 30-45℃. ​