Permeation enhancing composition, product and application thereof

Abstract

A permeation enhancing composition, a product and an application thereof are provided. The invention provides a penetration enhancing composition, which is prepared from the following components in parts by weight: 0.1 to 10 parts of lactobionic acid, 0.1 to 30 parts of cryptomeria fortunei bud extract, 0.1 to 40 parts of seasoning murraya paniculata stem extract and 0.001 to 1 part of collagen. The invention also provides application of the composition in preparation of products for promoting collagen percutaneous penetration. The lactobionic acid, the cryptomeria fortunei bud extract and the seasoning murraya paniculata stem extract are compounded for use, and are added into a product containing collagen for use, so that the percutaneous penetration of the collagen can be promoted, and the effects of whitening, moisturizing, resisting aging, repairing skin barriers and the like of the collagen as an active molecule are enhanced. The lactobionic acid does not need to be prepared into supramolecules, so that the preparation steps are reduced; the lactobionic acid, the cryptomeria fortunei bud extract and the seasoning murraya paniculata stem extract are mixed to be used for percutaneous penetration of the collagen, the preparation is stable and mild, and percutaneous penetration of the collagen can be stably promoted.

Description

Technical Field

[0001] The present invention relates to the field of cosmetics, in particular to a penetration-enhancing composition, a product and applications thereof. Background Art

[0002] Collagen is a structural protein that constitutes the extracellular matrix (ECM), accounting for about 75% of the skin's dermis. It is the main component of the dermis and has multiple biologically active functions, such as supporting skin contour, maintaining skin elasticity, regulating skin metabolism, and repairing skin tissue.

[0003] Currently, collagen supplements can be divided into two sources: animal-derived collagen and recombinant human collagen derived from synthetic biology. Compared to animal-derived collagen, recombinant human collagen offers several advantages, including high homology, low potential toxicity, high water solubility, and high stability. Research has shown that larger molecular weight proteins have more complete structures and higher biological activity, but large molecular weight proteins have relatively poor transdermal performance in cosmetic applications.

[0004] The prior art discloses the use of water-soluble vitamin E to promote the transdermal absorption of poorly absorbed fat-soluble compounds such as collagen, peptides, and glycosides, which can significantly improve skin condition. However, the water-soluble vitamin E is not very effective in promoting the transdermal absorption of type III collagen, and a large amount needs to be added to meet the amount required for the human body to absorb collagen. Chinese patent application CN117959207A discloses a highly transdermal supramolecular recombinant collagen, which is compounded with fruit acid and alkaline amino acids and prepared into supramolecular recombinant collagen, thereby increasing the transdermal permeability of collagen. However, the supramolecular structure prepared by this method is reversible, and external conditions such as ambient temperature and concentration will affect the supramolecular structure, thereby affecting the permeability of collagen. Summary of the Invention

[0005] In view of this, the present invention provides a penetration-enhancing composition, product and application thereof. The penetration-enhancing composition provided in this application can effectively promote the transdermal penetration of collagen, especially recombinant collagen, and is not affected by external conditions such as ambient temperature.

[0006] Chinese patent application CN117959207A discloses that fruit acids, including lactobionic acid, need to be compounded with alkaline amino acids and prepared into supramolecular recombinant collagen in order to promote the transdermal penetration of type III collagen, while the use of 3% lactobionic acid alone cannot promote the transdermal penetration of type III collagen. On this basis, the applicant found that compounding lactobionic acid with cedar bud extract and the seasoning Murraya odorifera stem extract can significantly improve the transdermal penetration of collagen, especially type III collagen.

[0007] Based on this, the present application provides a penetration-enhancing composition, which comprises, by weight: 0.1 to 10 parts of lactobionic acid, 0.1 to 30 parts of Japanese cedar bud extract, 0.1 to 40 parts of the seasoning Murraya odorifera stem extract and 0.001 to 1 part of collagen.

[0008] Lactobionic acid is a polyhydroxy biomimetic acid with the molecular formula C 12 H 22 O 12 , the structural formula is shown in formula (I), and it has broad application prospects in the food, pharmaceutical and chemical industries. Lactobionic acid has multiple functions such as moisturizing, repairing, anti-aging, and anti-oxidation. For example, lactobionic acid contains eight hydrophilic hydroxyl groups, so it has good hygroscopicity and can bind water in the epidermis. As an effective moisturizer, it softens the skin surface and reduces the appearance of fine wrinkles. For example, lactobionic acid can chelate with metal ions, inhibit the activity of matrix metalloproteinases (MMPs), play a role in protecting collagen, improve skin elasticity, and effectively reduce the effects of photoaging. Moreover, lactobionic acid has a significant effect on improving the homeostasis of the epidermal barrier and the function of the stratum corneum, but it does not have side effects such as irritation and stinging similar to traditional hydroxy acids (such as glycolic acid), and can act on sensitive skin.

[0009]

[0010] Cryptomeria japonica bud extract, also known as CRYPTOMERIA JAPONICA BUD EXTRACT, is an extract extracted from the tender buds of Cryptomeria japonica and has the following effects:

[0011] (1) Promote the regeneration of skin tissue structure: Cryptomeria japonica bud extract can stimulate the regeneration of skin cells, enhance the vitality of skin tissue, and help reshape a healthy skin structure.

[0012] (2) Comprehensively strengthen the skin: Cryptomeria japonica bud extract has antioxidant and anti-free radical properties, which can effectively resist the effects of harmful factors in the environment on the skin, thereby comprehensively improving the skin's resistance.

[0013] (3) Create a moist and plump texture: Cryptomeria japonica bud extract contains rich natural moisturizing ingredients, which can effectively retain the skin's moisture, making the skin more hydrated, plump and elastic.

[0014] (4) Forming a barrier to protect the skin: Cryptomeria japonica bud extract can form a protective film on the surface of the skin, effectively blocking external stimuli and pollution, thereby protecting the skin from external damage.

[0015] (5) Anti-allergic: Cryptomeria japonica bud extract has excellent anti-inflammatory and anti-allergic effects, which can effectively relieve skin allergy symptoms, reduce allergic reactions, and make the skin healthier and more comfortable.

[0016] The present application does not particularly limit the source of the Cryptomeria japonica bud extract; commercially available products are sufficient. In some specific implementations, the Cryptomeria japonica bud extract is a commercially available product extracted with water and butylene glycol, and has an isopimaric acid content greater than 150 ppm, preferably greater than 170 ppm, more preferably greater than 190 ppm, and most preferably greater than 200 ppm.

[0017] Murraya Koenigii Stem Extract, also known as Murraya Koenigii Stem Extract, is an extract from the stem of Murraya exotica L., a plant of the Rutaceae family. Murraya Koenigii stem extract can promote skin cell metabolism, accelerating the shedding of old cells and the formation of new ones, restoring skin's radiance and elasticity.

[0018] The present application has no particular restrictions on the source of the Murraya odorata stem extract, and any commercially available product may be used. In some specific implementations, the Murraya odorata stem extract is a commercially available product extracted from water, propylene glycol, and betaine, and has a flavonoid content greater than 30 ppm, preferably greater than 35 ppm.

[0019] Collagen is a biopolymer with multiple effects such as whitening, moisturizing, and anti-aging. The present application has no special restrictions on the collagen, and it can be type I collagen, type II collagen, type III collagen, type IV collagen, type V collagen, type VI collagen, type VII collagen, type XVII collagen, etc., preferably type III collagen. In the present application, the molecular weight of the collagen is preferably 5KDa to 100kDa, more preferably 6kDa to 80kDa, and most preferably 10kDa to 55kDa. The experimental results show that lactobionic acid, cedar bud extract and condiment Murraya odorifera stem extract can significantly promote the transdermal penetration of collagen.

[0020] In some embodiments of the present invention, the penetration-enhancing composition comprises, by weight, 0.5-6 parts of lactobionic acid, 0.5-20 parts of Cryptomeria japonica bud extract, 0.5-30 parts of Murraya odorifera stem extract, and 0.005-0.5 parts of collagen.

[0021] In some embodiments of the present invention, the penetration-enhancing composition comprises, by weight, 0.5-6 parts of lactobionic acid, 1-20 parts of Cryptomeria japonica bud extract, 3-30 parts of Murraya oleifera stem extract, and 0.01-0.2 parts of collagen.

[0022] In some embodiments of the present invention, the penetration-enhancing composition comprises, by weight, 1 to 6 parts of lactobionic acid, 2 to 10 parts of Cryptomeria japonica bud extract, 5 to 15 parts of Murraya odorifera stem extract, and 0.01 to 0.15 parts of collagen.

[0023] In some embodiments of the present invention, the penetration-enhancing composition comprises, by weight, 5 to 6 parts of lactobionic acid, 5 to 8 parts of Cryptomeria japonica bud extract, 5 to 10 parts of Murraya odorifera stem extract, and 0.05 to 0.15 parts of collagen.

[0024] In some embodiments of the present invention, the penetration-enhancing composition comprises, by weight, 5-6 parts of lactobionic acid, 5-7 parts of Cryptomeria japonica bud extract, 5-7 parts of Murraya odorifera stem extract, and 0.01-0.1 parts of collagen.

[0025] In some embodiments of the present invention, the penetration-enhancing composition comprises, by weight, 6 parts of lactobionic acid, 6 parts of Cryptomeria japonica bud extract, 6 parts of Murraya odorifera stem extract and 0.1 parts of collagen.

[0026] In some embodiments of the present invention, the penetration-enhancing composition comprises, by weight, 1 part of lactobionic acid, 1 part of Cryptomeria japonica bud extract, 3 parts of Murraya oleifera stem extract, and 0.1 part of collagen.

[0027] In some embodiments of the present invention, the penetration-enhancing composition comprises, by weight, 4 parts of lactobionic acid, 10 parts of Cryptomeria japonica bud extract, 12 parts of Murraya oleifera stem extract, and 0.1 parts of collagen.

[0028] In some embodiments of the present invention, the penetration-enhancing composition comprises, by weight, 0.5 parts of lactobionic acid, 20 parts of Cryptomeria japonica bud extract, 30 parts of Murraya odorifera stem extract, and 0.1 parts of collagen.

[0029] The present invention also provides an application of the composition in preparing a product for promoting transdermal collagen penetration. The composition comprises, by weight, 0.1 to 10 parts of lactobionic acid, 0.1 to 30 parts of cedar bud extract, and 0.1 to 40 parts of Murraya odorifera stem extract.

[0030] In some embodiments of the present invention, the above composition comprises, by weight, 0.5 to 6 parts of lactobionic acid, 0.5 to 20 parts of Cryptomeria japonica bud extract, and 0.5 to 30 parts of Murraya odorifera stem extract.

[0031] In some embodiments of the present invention, the above composition comprises, by weight, 0.5 to 6 parts of lactobionic acid, 1 to 20 parts of Cryptomeria japonica bud extract, and 3 to 30 parts of Murraya odorifera stem extract.

[0032] In some embodiments of the present invention, the above composition comprises, by weight, 1 to 6 parts of lactobionic acid, 2 to 10 parts of Cryptomeria japonica bud extract, and 5 to 15 parts of Murraya odorifera stem extract.

[0033] In some embodiments of the present invention, the above composition comprises, by weight, 5 to 6 parts of lactobionic acid, 5 to 8 parts of Cryptomeria japonica bud extract, and 5 to 10 parts of Murraya odorifera stem extract.

[0034] In some embodiments of the present invention, the above composition comprises, by weight, 5 to 6 parts of lactobionic acid, 5 to 7 parts of Cryptomeria japonica bud extract, and 5 to 7 parts of Murraya odorifera stem extract.

[0035] In some embodiments of the present invention, the above composition comprises, by weight, 6 parts of lactobionic acid, 6 parts of Cryptomeria japonica bud extract and 6 parts of Murraya odorifera stem extract.

[0036] In some embodiments of the present invention, the above composition comprises, by weight, 1 part of lactobionic acid, 1 part of Cryptomeria japonica bud extract, and 3 parts of Murraya odorifera stem extract.

[0037] In some embodiments of the present invention, the above composition comprises, by weight, 4 parts of lactobionic acid, 10 parts of Cryptomeria japonica bud extract and 12 parts of Murraya odorifera stem extract.

[0038] The present invention also provides a product, comprising: the penetration-enhancing composition described in the above technical solution.

[0039] In some embodiments of the present invention, the above-mentioned products include but are not limited to personal care products, medicines, etc. Those skilled in the art will understand that, in addition to the composition described in the above technical solution, other excipients may also be included, such as pharmaceutical excipients or excipients for personal care products.

[0040] In some embodiments of the present invention, the personal care product includes: a basic care product and / or a makeup product.

[0041] In some embodiments of the present invention, the cosmetic products include but are not limited to:

[0042] (1) Foundation makeup:

[0043] Liquid foundation / cream: used to even out skin tone and cover blemishes;

[0044] BB Cream / CC Cream: A lightweight makeup base that combines skincare and finishing touches.

[0045] Concealer / pen: for covering local areas such as acne, dark circles, etc.

[0046] Loose powder / face powder: sets makeup and reduces facial shine.

[0047] (2) Eye makeup:

[0048] Eyeshadow: adds color and depth to the eyes;

[0049] Eyeliner pencil / liquid / gel: outline the eyeliner to make the eyes look more vivid;

[0050] Mascara: lengthens and thickens eyelashes, adds depth to eyes;

[0051] Eyebrow pencil / eyebrow powder / eyebrow gel: fill in the gaps in the eyebrows and shape the ideal eyebrows.

[0052] (3) Cheek makeup:

[0053] Blush: Add natural redness to cheeks and enhance complexion;

[0054] Contouring cake / stick: Use shading techniques to make the facial contours more three-dimensional;

[0055] (4) Lip makeup:

[0056] Lipstick / Lip Glaze / Lip Gloss: Change or emphasize the color of the lips;

[0057] Lip liner: Draw a clear lip boundary to prevent lipstick from overflowing.

[0058] (5) Multifunctional cosmetics:

[0059] Highlighter stick / liquid / powder: brightens the high points of the face (such as the bridge of the nose and cheekbones) to create a radiant look.

[0060] In addition, there are products designed specifically for special occasions, such as waterproof and sweat-proof eyeliner and long-lasting lipstick.

[0061] In some embodiments of the present invention, the basic care products include but are not limited to:

[0062] Facial Cleanser / Face Wash: Gently removes dirt, oil and makeup residue from the face;

[0063] Makeup remover oil / makeup remover water / makeup remover cream: specially designed to completely remove makeup, especially waterproof makeup;

[0064] Toner / Lotion: Use after cleansing to further cleanse residue on the skin surface, replenish moisture to the skin, restore the skin's pH balance, and lay a good foundation for the absorption of subsequent skin care products;

[0065] Essence: Contains high concentrations of active ingredients to provide deep nourishment and repair for specific skin problems (such as anti-aging, moisturizing, whitening, etc.);

[0066] Eye cream: specially designed for the sensitive area around the eyes, it can reduce fine lines, dark circles and tighten the skin around the eyes. The texture is usually light and easy to absorb.

[0067] Day / night lotion or cream: has the functions of protecting, repairing and nourishing, promoting cell regeneration, etc., which can provide the skin with necessary moisture and lock in the replenished moisture;

[0068] Sunscreen: used for UV protection, prevention of photoaging, etc.;

[0069] Facial masks: Provide extra nourishment and care to the skin, such as hydration, pore cleansing or brightening.

[0070] This application adds lactobionic acid, Cryptomeria japonica bud extract, seasoning Murraya osmanthus stem extract and collagen to the above-mentioned products for use, which can promote the transdermal absorption of collagen, thereby enhancing the whitening, moisturizing, anti-aging, skin barrier repair and other effects of collagen as an active molecule. This application has no special restrictions on other active ingredients in the product, and they can be added as needed. This application also has no special restrictions on the excipients in the product, and they can be added according to the product type. This application has no special restrictions on the preparation method of the product, and the preparation method can be adjusted according to the specific substances selected in the product formula.

[0071] This application uses a compound of lactobionic acid, cedar bud extract, and the seasoning Murraya paniculata stem extract, and adds them to products containing collagen to promote the transdermal penetration of collagen, thereby enhancing the whitening, moisturizing, anti-aging, and skin barrier repair effects of collagen as an active molecule. This application does not require the preparation of lactobionic acid into a supramolecule, reducing the preparation steps; this application can be used for the transdermal penetration of collagen by mixing lactobionic acid, cedar bud extract, and the seasoning Murraya paniculata stem extract. The preparation is stable, mild, and can stably promote the transdermal penetration of collagen. DETAILED DESCRIPTION

[0072] The invention discloses a penetration-enhancing composition, a product and applications thereof.

[0073] It should be understood that the expression "one or more of" includes individually each of the items recited after the expression and various combinations of two or more of the recited items, unless otherwise apparent from the context and usage. The expression "and / or" in conjunction with three or more recited items should be understood to have the same meaning, unless otherwise apparent from the context.

[0074] The terms "comprising", "having" or "containing", including their grammatical synonyms, should generally be understood as open and non-restrictive, e.g., not excluding other unrecited elements or steps, unless otherwise specifically stated or understood from the context.

[0075] It should be understood that the order of steps or the order in which certain actions are performed are not important as long as the present invention remains operable. Additionally, two or more steps or actions may be performed simultaneously.

[0076] The use of any and all examples or exemplary language, such as "such as" or "including," herein is intended merely to better illustrate the invention and does not limit the scope of the invention unless otherwise claimed. No language in this specification should be construed as indicating any non-claimed element as essential to the practice of the invention.

[0077] In addition, the numerical ranges and parameters used to define the present invention are approximate values. The relevant numerical values in the specific examples have been presented as accurately as possible. However, any numerical value inherently inevitably contains standard deviations due to individual testing methods. Therefore, unless otherwise expressly stated, all ranges, amounts, values, and percentages used in this disclosure should be understood to be modified by the word "about." As used herein, "about" generally means that the actual value is within plus or minus 10%, 5%, 1%, or 0.5% of a specified value or range.

[0078] The present application provides a penetration-enhancing composition, which comprises, by weight, 0.1 to 10 parts of lactobionic acid, 0.1 to 30 parts of cedar bud extract, 0.1 to 40 parts of Murraya odorifera stem extract, and 0.001 to 1 part of collagen.

[0079] The present invention also provides an application of the composition in preparing a product for promoting transdermal collagen penetration. The composition comprises, by weight, 0.1 to 10 parts of lactobionic acid, 0.1 to 30 parts of cedar bud extract, and 0.1 to 40 parts of Murraya odorifera stem extract.

[0080] This application uses a compound of lactobionic acid, cedar bud extract, and the seasoning Murraya paniculata stem extract, and adds them to products containing collagen to promote the transdermal penetration of collagen, thereby enhancing the whitening, moisturizing, anti-aging, and skin barrier repair effects of collagen as an active molecule. This application does not require the preparation of lactobionic acid into a supramolecule, reducing the preparation steps; this application can be used for the transdermal penetration of collagen by mixing lactobionic acid, cedar bud extract, and the seasoning Murraya paniculata stem extract. The preparation is stable, mild, and can stably promote the transdermal penetration of collagen.

[0081] The present invention will be further described below with reference to the embodiments.

[0082] In the following examples and comparative examples, the cedar bud extract and the condiment Murraya paniculata stem extract were purchased on the market. Among them, the cedar bud extract was obtained by extraction with water and butylene glycol, and its isopimaric acid content was about 200 ppm; the condiment Murraya paniculata stem extract was obtained by extraction with water, propylene glycol and betaine, and its flavonoid content was about 35 ppm.

[0083] Type III collagen is recombinant type III collagen with a molecular weight of 10KDa to 55KDa.

[0084] Examples 1 to 4, Comparative Examples 1 to 3

[0085] According to the formula shown in Table 1, corresponding weights of lactobionic acid, Cryptomeria japonica bud extract and Murraya oleifera stem extract were mixed to obtain a composition.

[0086] Table 1 Composition formulas provided in Examples and Comparative Examples

[0087]

[0088] Test Example 1

[0089] This test is based on a suckling pig skin-Franz cell diffusion cell system. The Franz diffusion cell permeability experiment was conducted on different samples using suckling pig back skin to examine the transdermal ability of the samples through the isolated pig back skin.

[0090] Type III collagen was added to the compositions provided in the Examples and Comparative Examples. The final concentrations of the components in the resulting solutions were shown in Table 2, and these solutions were used as test samples.

[0091] Table 2 Test concentrations of each component in Examples and Comparative Examples

[0092]

[0093] The specific test steps are as follows:

[0094] (1) Add receiving solution to the receiving chamber: Use a pipette to draw 7.0 mL of receiving solution (physiological saline) into the receiving chamber, and place the matching magnetic stirring bar in the receiving chamber.

[0095] (2) Assembly and fixation of the test model: The pig skin was fixed between the diffusion chamber and the receiving chamber of the Franz cell diffusion tank, with the pig skin stratum corneum facing the diffusion chamber and the dermis facing the receiving chamber. After the pig skin was fixed, 0.5 mL of receiving solution (normal saline) was added to the sampling tube using a pipette according to the liquid level in the sampling tube, so that the pig skin dermis layer was in close contact with the receiving solution, and the total volume of the receiving solution was 7.5 mL.

[0096] (3) The Franz cell diffusion cell was fixed in the transdermal absorption diffusion instrument, and the electromagnetic stirrer was turned on to stir at a speed of 300 rpm and maintained in a constant temperature air bath of (32±1)℃.

[0097] (4) Sampling: After the air bath temperature of the diffuser is constant, sample loading is performed. 400 μL of the sample shown in Table 2 is drawn into the syringe and added to the surface of the suckling pig skin.

[0098] (5) Subcutaneous sample collection: Collect samples at 4 hours and 8 hours.

[0099] (6) Treatment of the unpenetrated part of the skin: After 8 hours of penetration, use a pipette to draw up physiological saline and blow it repeatedly to clean the surface of the suckling pig skin. Wash three times and adjust the volume to 2.0 mL.

[0100] (7) Treatment of residual parts in the skin: After 8 h of infiltration, the suckling pig skin was cut into pieces and placed in a 2.0 mL EP tube. The volume was adjusted to 2.0 mL with normal saline and ultrasonicated for 30 minutes.

[0101] (8) The total protein content of samples at each time point was quantitatively analyzed by the Coomassie brilliant blue method, and the permeability at each time point was calculated according to formula 1:

[0102] P=Q / P0×100% Formula 1

[0103] Wherein, P is the permeability, Q is the cumulative permeation amount in the receiving chamber at each time point, and P0 is the sample load in the diffusion chamber (sample load = sample volume × sample concentration).

[0104] The results are shown in Table 3, which shows the transdermal effects obtained from the test examples of this application.

[0105] Table 3 Transdermal effects of Examples and Comparative Examples

[0106]

[0107] As can be seen from Table 3, the composition provided by the present application can effectively promote the penetration of collagen.

[0108] The synergistic coefficient of the total protein permeability of the composition provided in Example 1 over 4 h relative to Comparative Example 1 and Comparative Example 2 was calculated according to the King's method, and the calculation formula is as follows:

[0109] q=E A+B / (E A +E B -E A *E B )

[0110] Among them, q is the synergy coefficient, E A+B is the total protein permeability enhancement rate of Example 14h, E Ais the total protein permeation improvement rate of the comparative example 14h, E B It is the total protein permeation enhancement rate of the comparative example for 24 hours.

[0111] After calculation, q=3.95, which shows that the combination of Cryptomeria japonica bud extract and the seasoning Murraya oleifera stem extract with lactobionic acid significantly increases the effect of lactobionic acid in promoting collagen penetration.

[0112] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as within the scope of protection of the present invention.

Claims

1. A penetration-enhancing composition, comprising, by weight: 0.1-10 parts of lactobionic acid, 0.1-30 parts of Japanese cedar bud extract, 0.1-40 parts of seasoning Murraya odorifera stem extract and 0.001-1 part of collagen.

2. The penetration-promoting composition according to claim 1, wherein The invention comprises, by weight, 0.5 to 6 parts of lactobionic acid, 0.5 to 20 parts of cedar bud extract, 0.5 to 30 parts of Murraya odorifera stem extract and 0.005 to 0.5 parts of collagen.

3. The penetration-promoting composition according to claim 2, wherein Calculated by weight, it comprises: 6 parts of lactobionic acid, 6 parts of cedar bud extract, 6 parts of Murraya paniculata stem extract and 0.1 parts of collagen; Or it may include: 1 part of lactobionic acid, 1 part of Cryptomeria japonica bud extract, 3 parts of Murraya oleifera stem extract and 0.1 part of collagen; Or it includes: 4 parts of lactobionic acid, 10 parts of Japanese cedar bud extract, 12 parts of seasoning Murraya paniculata stem extract and 0.1 parts of collagen; Alternatively, the invention comprises: 0.5 parts of lactobionic acid, 20 parts of cedar bud extract, 30 parts of Murraya paniculata stem extract and 0.1 parts of collagen.

4. The penetration-enhancing composition according to any one of claims 1 to 3, characterized in that The cryptomeria japonica bud extract is obtained by extracting water and butylene glycol; The content of isopimaric acid in the Cryptomeria japonica bud extract is greater than 150 ppm; The seasoning Murraya paniculata stem extract is obtained by extracting water, propylene glycol and betaine; The flavonoid content in the seasoning Murraya paniculata stem extract is greater than 30 ppm.

5. The penetration-promoting composition according to claim 4, wherein The collagen is type I collagen, type III collagen, type IV collagen, type V collagen, type VII collagen or type XVII collagen.

6. Use of a composition for preparing a product for promoting transdermal collagen penetration, wherein the composition comprises, in parts by weight: 0.1-10 parts of lactobionic acid, 0.1-30 parts of Japanese cedar bud extract and 0.1-40 parts of seasoning Murraya odorifera stem extract.

7. The use according to claim 6, characterized in that The composition comprises, by weight, 0.5 to 6 parts of lactobionic acid, 0.5 to 20 parts of cedar bud extract and 0.5 to 30 parts of Murraya odorifera stem extract.

8. The use according to claim 6 or 7, characterized in that The collagen is type I collagen, type III collagen, type IV collagen, type V collagen, type VII collagen or type XVII collagen.

9. The product, characterized in that include: The penetration enhancing composition according to any one of claims 1 to 5.

10. The product according to claim 8, characterized in that The products include: basic care products and / or makeup products.

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