Application of vitexin in preparation of medicine for preventing and treating obesity

By using vinyl syringin to promote heat production and UCP1 protein expression in brown adipocytes, the problems of side effects of obesity drugs and weight rebound in the prior art are solved, and effective obesity prevention and treatment effects are achieved.

CN120437151APending Publication Date: 2025-08-08HANGZHOU FIRST PEOPLES HOSPITAL
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Patent Information

Application Number
CN202510500713.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-04-21
Publication Date
2025-08-08

AI Technical Summary

Technical Problem

The prior art lacks effective, low-toxic natural small molecule drugs for preventing and treating obesity, and the existing drugs have side effects and problems of weight rebound after stopping the drug.

Method used

Varviparin is used as a natural diterpene glycoside compound and is administered through intraperitoneal injection to promote heat production of brown adipocytes, increase UCP1 protein expression, and improve the body's metabolic rate. It is prepared into solutions, powders, sustained-release agents and other drugs for preventing and treating obesity.

Benefits of technology

Vinyl saccharin significantly reduces obesity induced by a high-fat diet, improves insulin resistance, reduces subcutaneous white adipose tissue, improves overall metabolic rate, and has no obvious toxic side effects.

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Abstract

The invention discloses application of vitexin in preparation of medicines for preventing and treating obesity. According to the application of the vitexin in preparation of the medicine for preventing and treating the obesity, the prevention and treatment comprise one or more of prevention, relieving or treatment of the obesity induced by high fat diet, and the medicine can be generally a solution and contains pharmaceutically acceptable auxiliary materials. The vitexin disclosed by the invention can promote the heat production of brown adipocytes and increase the oxygen consumption; the expression of heat production marker protein UCP1 of brown fat and subcutaneous white fat tissues is increased, the metabolic rate of an organism is increased, obesity induced by high fat diet is resisted, and then insulin resistance is improved.
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