Multi-parameter thrombus risk detector

Abstract

The invention discloses a multi-parameter thrombus risk detector, and relates to the technical field of medical instruments, the multi-parameter thrombus risk detector comprises a test unit, and the test unit comprises a first blood storage tube, a capillary tube, a second blood storage tube, a driving system and a detection system. The first blood storage tube is used for storing a whole blood sample; part of the inner wall of the capillary tube is coated with collagen, and part of the inner wall of the capillary tube is coated with serum albumin; the capillary tube is used for circulating whole blood and providing a space for forming thrombus, two ends of the capillary tube are respectively an inlet end for inputting the whole blood into the capillary tube and an outlet end for outputting the whole blood in the capillary tube, and the inlet end of the capillary tube is communicated with the first blood storage tube; the second blood storage tube is communicated with the outlet end of the capillary tube and is used for storing whole blood flowing out of the capillary tube; scales for indicating the volume of internal liquid are formed on the wall surface of the second blood storage tube; the driving system is used for driving total blood in the first blood storage tube to flow into the capillary tube and then flow into the second blood storage tube for storage; according to the invention, the individual thrombosis risk can be accurately evaluated.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a multi-parameter thrombosis risk detector. Background Art

[0002] Adverse cardiovascular events such as myocardial infarction, stroke, pulmonary embolism, and deep vein thrombosis are currently the most common diseases and the most common cardiovascular diseases that threaten life and health. A large proportion of these events are classified as ischemic events, which are characterized by reduced tissue blood flow and accompanied by cellular damage. In arterial ischemic events, the process of blood clot formation is called arterial thrombosis. The clots formed in the high shear environment of the artery are different from those formed through the coagulation cascade.

[0003] Existing thrombosis detection technologies struggle to accurately simulate the process of arterial thrombosis. Furthermore, many methods, such as light transmission aggregometry and platelet function analyzers, rely on chemical inducers to stimulate platelets, causing them to aggregate. These methods differ significantly from the natural thrombosis process in vivo and fail to reflect the true mechanism of thrombosis. These limitations pose a challenge to the accurate detection and assessment of arterial thrombosis in clinical practice, creating an urgent need for more effective detection methods. Summary of the Invention

[0004] The purpose of the present invention is to provide a multi-parameter thrombosis risk detector to solve the problems existing in the above-mentioned prior art and accurately assess the risk of individual thrombosis.

[0005] To achieve the above object, the present invention provides the following solutions: The present invention provides a multi-parameter thrombosis risk detector, comprising a plurality of test units, wherein the test units include: a first blood reservoir, a capillary tube, a second blood reservoir, a driving system and a detection system. The first blood reservoir is used to store whole blood samples. At least four capillaries are provided, at least three of which are test tubes and at least one is a control tube. The inner walls of the test tubes are coated with collagen, and the inner walls of the control tubes are coated with serum albumin. The test tubes are used to circulate whole blood and provide space for thrombus formation. The capillaries have an inlet for inputting whole blood into the capillaries and an outlet for outputting whole blood from the capillaries, respectively. The inlet of the capillary is connected to the first blood reservoir. The number of second blood reservoirs is the same as the number of capillaries, and they are arranged in a one-to-one correspondence. The second blood reservoirs are connected to the outlet of the capillaries and are used to store whole blood flowing out of the capillaries. The walls of the second blood reservoirs are provided with scales indicating the internal liquid volume. A drive system is used to drive the whole blood in the first blood reservoir to flow into the capillaries and then into the second blood reservoir for storage. The detection system is capable of at least detecting the flow rate of whole blood entering each second blood reservoir and the time from the start of the test to the flow rate detection reaching zero.

[0006] In some embodiments, the driving system is a vacuum pump, the top end of the second blood reservoir is connected to the negative pressure port of the vacuum pump, and the bottom end is connected to the outlet end of the capillary tube; the vacuum pump can drive the whole blood in the first blood reservoir to flow to the capillary tube and then into the second blood reservoir for storage at a specific negative pressure.

[0007] In some embodiments, the first blood storage tube is a blood collection tube, and the capillary tube is a capillary glass tube.

[0008] In some embodiments, each of the test units is provided with a control tube and a plurality of test tubes.

[0009] In some embodiments, one of the first blood reservoirs in the same test unit can be connected to the inlet ends of multiple capillaries through a blood perfusion connecting tube, and the blood perfusion connecting tube is provided with a blood buffer zone with a larger cross-sectional area than the blood perfusion connecting tube.

[0010] In some embodiments, the plurality of second blood reservoirs are vertically arranged, and their top ends are connected to the negative pressure port of the vacuum pump through the same vacuum pump connecting tube.

[0011] In some embodiments, a support platform is further provided, which is used to support the first blood storage tube, capillary tube, second blood storage tube and drive system, wherein the capillary tube is arranged horizontally and the first blood storage tube is arranged vertically; a blood collection tube placement port connected to the inlet end of the capillary tube is constructed on the support platform, and the blood collection tube is inserted into the blood collection tube placement port with the opening facing downward.

[0012] In some embodiments, a plurality of the test units are provided, the support platform is configured with the same number of blood collection tube placement ports as the number of the test units, and the plurality of test units share one drive system.

[0013] In some embodiments, a pressure display, a time display, and a flow display are provided on the support platform. The pressure display, the time display, and the flow display are all connected to the detection system. The pressure display is used to display the working pressure of the vacuum pump. The time display is used to display the time from the start of the test to the detection of the flow rate flowing into each second blood reservoir being zero. The flow display is used to display the flow rate of whole blood entering each second blood reservoir.

[0014] Compared with the prior art, the present invention has achieved the following technical effects: The multi-parameter thrombosis risk detector proposed by this invention encompasses three key factors contributing to thrombosis: whole blood, high shear forces, and the thrombus formation surface, providing a more comprehensive assessment of thrombosis risk. This multi-parameter thrombosis risk detector also avoids additional chemical stimulation, enabling a more realistic simulation of thrombosis formation and risk.

[0015] Furthermore, the thrombosis risk analyzer can also provide stable pressure to simulate the formation of thrombus under in vivo conditions.

[0016] Furthermore, the thrombosis risk analyzer can support the simultaneous operation of multiple test units, thereby achieving the purpose of testing multiple samples at the same time.

[0017] Furthermore, the thrombosis risk analyzer has the advantages of requiring only a small amount of blood and enabling immediate detection.

[0018] Furthermore, the thrombosis risk analyzer can also specifically target patients using antiplatelet drugs and pre-evaluate the effectiveness and safety of patients using antiplatelet drugs, providing patients with specific antiplatelet drug treatment plans. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0020] Figure 1 A schematic diagram of the structure of a multi-parameter thrombosis risk detector provided by an embodiment of the present invention; Figure 2 for Figure 1A schematic diagram of the structure of the connection between the first blood reservoir and each capillary tube and a partial enlarged diagram; Figure 3 A schematic diagram of the structure of the vacuum pump and the second blood storage tubes arranged on the support platform; Figure 4 for Figure 3 A schematic diagram of the structure of the connection between the vacuum pump and each second blood reservoir; Figure 5 for Figure 1 Schematic diagram of the structure connecting the middle capillary and the second blood reservoir.

[0021] In the figure: 1-first blood storage tube; 2-blood collection tube placement port; 3-support platform; 4-capillary tube; 5-vacuum pump connecting tube; 6-second blood storage tube; 7-vacuum pump; 8-pressure display; 9-time display; 10-flow display; 11-blood perfusion connecting tube; 12-buffer zone; 13-serum albumin; 14-collagen; 15-flow sensor; 16-terminal connecting tube; 17-vacuum pump pressure detection sensor; 18-vacuum suction connecting tube; 19-capillary tube group. DETAILED DESCRIPTION

[0022] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0023] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0024] The inventors believe that the formation of thrombus requires three key factors: whole blood, high shear force and thrombus formation surface. It relies on high shear stress to activate von Willebrand factor, which in turn mediates the natural process of platelet adhesion-aggregation-occlusion. Current methods for detecting the risk of thrombosis lack at least one of the three conditions mentioned above. For example, thromboelastography (TEG) and rotational thromboelastometry (ROTEM) lack high shear stress and pro-thrombotic surfaces, only detecting the coagulation cascade and failing to simulate shear-induced platelet aggregation. Light transmission aggregometry (LTA) and VerifyNow rely on chemical agonists (such as ADP) to stimulate platelets under static conditions without flow, which is different from the "high shear-driven von Willebrand activation" mechanism of shear-induced platelet aggregation. On the other hand, the detection methods are non-physiologically driven. For example, the platelet function analyzer (PFA-100) has a shear environment, but activates the blood by adding epinephrine / ADP, and the shear conditions are imprecise due to the rough pores. The total thrombosis assessment system (T-TAS) uses a constant flow drive, which causes the thrombus to rupture and reconstruct under non-physiological high pressure, failing to form a stable occlusive thrombus.

[0025] Among them, thromboelastography and rotational thromboelastometry identify coagulation by measuring the force transmitted from a blood sample in a rotating cup to a sensor without generating platelet thrombi. Moreover, the coagulation process is initiated chemically, and the detection method lacks the high shear stress or thrombogenic surface required for thrombosis. The full thrombosis assessment system is similar to the straight-channel microfluidic device used in thrombosis research.

[0026] Light transmission aggregometry involves adding a chemical agonist to plasma, which causes aggregate formation and precipitation, thereby increasing the light transmittance of the plasma. Light transmission aggregometry experiments are performed in the absence of flow, so these assays cannot generate the high shear forces required for von Willebrand factor elongation. Platelet function analyzers measure the time it takes for blood to plug the collagen-coated pores in the membrane. Due to the rough edges of the pores in the cellulose membrane, shear conditions are imprecise. Prior to flow, blood is activated in the platelet function analyzer kit by adding ADP or epinephrine.

[0027] In the full thrombosis assessment system, high shear stress induces platelet-rich thrombi to form on collagen surfaces. Thrombi occlude multiple parallel channels within the microfluidic device, resulting in increased fluidic resistance, as measured by an increase in upstream pressure. The full thrombosis assessment system assay has two limitations: First, because the constant-flow system drives blood flow, pressure on the thrombus can reach unphysiologically high levels (60 kPa, or approximately 450 mmHg), causing the thrombus to cycle between rupture and reformation. Second, the small size of the test section allows platelet adhesion to the surface to predominate over platelet-platelet growth. Furthermore, in a system with parallel channels, constant-flow conditions can result in extremely high shear rates in some channels, while others can approach stagnation due to flow diversion from the blocked channel. This means that flow in each test channel is not independent, and blockage of one channel can hinder the formation of a stable thrombus in the remaining unobstructed channel.

[0028] Factors that influence thrombosis include platelet activation, von Willebrand factor concentration and status, antiplatelet therapy, and blood viscosity. Rather than testing each factor individually, a functional test for thrombosis is very useful for diagnosing bleeding disorders in ischemic events and trauma patients, and for tailoring antiplatelet therapy to individuals.

[0029] Based on the core defect of the existing technology (the inability to truly simulate shear-induced platelet aggregation), the core purpose of the present invention is to provide an instant detection device that can reproduce the "high shear stress-von Willebrand factor-platelet-thrombogenic surface" interaction in vitro, without the need for chemical agonists, and accurately assess individual thrombosis risk and antiplatelet drug treatment regimens and efficacy by stably forming physiologically relevant occlusive thrombi.

[0030] Whole blood contains von Willebrand factor and platelets, so the above-mentioned "high shear stress-von Willebrand factor-platelets-prothrombotic surface" interaction can also be called "high shear stress-whole blood-prothrombotic surface" interaction.

[0031] The following combination Figures 1 to 5 , describing embodiments of the present invention.

[0032] The present invention provides a multi-parameter thrombosis risk detector, which includes a plurality of test units. The test units include: a first blood reservoir 1, a capillary tube 4, a second blood reservoir 6, a driving system and a detection system. The first blood reservoir 1 is used to store whole blood samples. At least two capillaries 4 are provided, at least one of which is a test tube and at least one is a control tube. The inner wall of the test tube is coated with collagen 14, and the inner wall of the control tube is coated with serum albumin 13. The test tube is used to circulate whole blood and provide space for thrombus formation. The capillaries 4 have an inlet for inputting whole blood into the capillaries 4 and an outlet for outputting whole blood from the capillaries 4. The inlet of the capillaries 4 is connected to the first blood reservoir 1. The number of second blood reservoirs 6 is the same as the number of capillaries 4 and is arranged in a one-to-one correspondence. The second blood reservoirs 6 are connected to the outlets of the capillaries 4 and are used to store whole blood flowing out of the capillaries 4. The walls of the second blood reservoirs 6 are constructed with scales indicating the internal liquid volume. A drive system is used to drive the whole blood in the first blood reservoir 1 to flow into the capillaries 4 and then into the second blood reservoirs 6 for storage. The detection system is capable of at least detecting the flow rate of whole blood entering each second blood reservoir 6 and the time from the start of the test to the flow rate detection reaching zero.

[0033] Principle: Collagen 14 coated within capillary tube 4 allows for adhesion to platelets. When a whole blood sample passes through the capillary tube coated with collagen 14, the platelets bind to the collagen 14 and von Willebrand factor, forming a thrombus that blocks the capillary tube. However, blood does not form a thrombus within capillary tube 4 when serum albumin 13 is coated, and instead flows into the second blood reservoir 6.

[0034] During use, the whole blood to be tested is temporarily stored in the first blood storage tube 1, and the driving system is used to drive the whole blood to flow to the capillary 4 and then into the second blood storage tube 6 for storage. When the whole blood flows in the capillary 4, a thrombus will gradually form to block the capillary 4. After the blockage, the whole blood in the capillary 4 will no longer flow toward the second blood storage tube 6. At this time, the flow rate detected by the detection system is zero, and the time from the start of the test to the flow rate detection being zero is recorded. The test can be stopped until all the capillaries 4 are blocked by thrombi or all the whole blood in the first blood storage tube 1 has flowed out. The test process data needs to be recorded during the test, and the staff can analyze the risk of thrombosis in the body of the whole blood sample based on the test process data.

[0035] The multi-parameter thrombosis risk detector proposed by this invention encompasses three key factors contributing to thrombosis: whole blood, high shear forces, and the thrombus formation surface, providing a more comprehensive assessment of thrombosis risk. This multi-parameter thrombosis risk detector also avoids additional chemical stimulation, enabling a more realistic simulation of thrombosis formation and risk.

[0036] In addition, the thrombosis risk analyzer provided by the present invention can be used to test different samples (whole blood samples), wherein the dosage or type of drug added in each sample is different, and at least one whole blood sample has no drug added, that is, the drug dosage is zero. After the test is completed, the test results can be compared to analyze the impact of the drug type and dosage on the thrombosis process.

[0037] Therefore, the thrombosis risk analyzer can also specifically target patients using antiplatelet drugs and pre-evaluate the effectiveness and safety of patients using antiplatelet drugs, providing patients with specific antiplatelet drug treatment plans.

[0038] In some embodiments, the driving system is a vacuum pump 7, the top of the second blood reservoir 6 is connected to the negative pressure port of the vacuum pump 7, and the bottom is connected to the outlet end of the capillary 4; the vacuum pump 7 can drive the whole blood in the first blood reservoir 1 to flow to the capillary 4 and then into the second blood reservoir 6 for storage at a specific negative pressure.

[0039] This embodiment uses vacuum suction to drive whole blood flow within capillary tube 4. The operating state of vacuum pump 7 is adjustable, thereby achieving the goal of adjustable negative pressure and adjustable shear force on the thrombus. Vacuum pump 7 provides stable pressure, simulating thrombus formation under in vivo conditions. Furthermore, this negative pressure does not contaminate the whole blood, further enhancing the realism of the simulation.

[0040] Of course, in some instances, a peristaltic pump or other solution that causes less contamination to the whole blood may be used to drive the whole blood.

[0041] In some embodiments, the first blood storage tube 1 is a blood collection tube, and the capillary tube 4 is a capillary glass tube.

[0042] This thrombosis risk analyzer directly uses a blood collection tube as the first blood reservoir 1. The blood collection tube only needs to collect 2-3 mL of blood. Therefore, this embodiment offers the advantages of minimal blood usage and immediate testing. Furthermore, the capillary glass tube, i.e., the capillary tube 4, is made of a transparent material, facilitating observation of the thrombosis formation process within the capillary glass tube. If necessary, a camera can be provided to record video of the thrombosis formation for subsequent analysis and judgment.

[0043] In some examples, the first blood storage tube 1 may not use a blood collection tube. In this case, a process of transferring the blood collected in the blood collection tube to the first blood storage tube 1 is required, which increases the risk of contamination.

[0044] In some embodiments, each test unit is provided with a control tube and a plurality of test tubes.

[0045] In a specific example, three test tubes are set up, and the test conditions in the three test tubes are the same. After the test is completed, the accidental data can be discarded based on the test process data, and then the test error can be reduced by taking the average of the remaining data.

[0046] Of course, in some examples, more test tubes, such as 5, etc., can be selected, and multiple control tubes can also be set, such as three.

[0047] In some embodiments, a first blood reservoir 1 in the same test unit can be connected to the inlet ends of multiple capillaries 4 through a blood perfusion connecting tube 11, and a blood buffer zone 12 having a larger cross-sectional area than the blood perfusion connecting tube 11 is provided on the blood perfusion connecting tube 11.

[0048] The buffer zone 12 in this embodiment is provided to reduce pressure fluctuations in the capillary tube 4 and thereby improve authenticity.

[0049] In some embodiments, such as Figure 4 As shown, multiple second blood storage tubes 6 are vertically arranged, and their top ends are connected through the same vacuum pump connecting tube 5 and the negative pressure port of the vacuum pump 7. Specifically, the vacuum pump connecting tube 5 and the top of the second blood storage tube 6 are connected through a vacuum suction connecting tube 18.

[0050] This embodiment uses one vacuum pump 7 to achieve the purpose of driving the whole blood to flow in all the capillaries 4.

[0051] In some embodiments, the embodiments of the present invention are further provided with a support platform 3, which is used to support the first blood storage tube 1, the capillary tube 4, the second blood storage tube 6 and the driving system. The capillary tube 4 is arranged horizontally and the first blood storage tube 1 is arranged vertically; a blood collection tube placement port 2 connected to the inlet end of the capillary tube 4 is constructed on the support platform 3, and the blood collection tube is inserted into the blood collection tube placement port 2 with the opening facing downward.

[0052] This embodiment achieves the purpose of integrating multiple components and realizes modular design.

[0053] In some embodiments, such as Figure 1 As shown, a plurality of test units are provided, and the support platform 3 is provided with blood collection tube placement ports 2 having the same number as the test units, and the plurality of test units share a driving system.

[0054] The thrombosis risk analyzer provided in this embodiment can support the simultaneous operation of multiple test units to achieve the purpose of testing multiple samples at the same time, that is, the first blood storage tubes 1 in different test units can contain different whole blood samples.

[0055] Specifically, the multiple capillaries 4 in each test unit can be integrated to form a tube group module, namely, a capillary tube group 19. In some examples, such as Figure 2 As shown, the blood perfusion connecting tube 11, the blood buffer zone 12 and the four capillaries 4 together form a capillary tube group 19, and the inlet end of the blood perfusion connecting tube 11 is plugged into an underflow port at the bottom of the blood collection tube placement port 2.

[0056] Multiple second blood reservoirs 6 can also form a tube group module. The tube group module composed of multiple second blood reservoirs 6 and the tube group module formed by integrating multiple capillaries 4 can be detachably set on the support platform 3 and connected or communicated with other structures by plugging.

[0057] In addition, considering that in some usage scenarios, not all test units may be used at the same time, in order to avoid negative pressure leakage, a cover or valve can be used to seal the blood collection tube placement port 2. Of course, this is only an example.

[0058] In some embodiments, the vacuum pump 7 can make the shear rate of the whole blood in the capillary 4 be 1000s -1 -30000s -1 .

[0059] In this embodiment, different shear rates are selected according to different groups of people to improve adaptability and authenticity.

[0060] In some embodiments, the cross-section of the capillary 4 can be circular, elliptical, rectangular, etc. When the cross-section is circular, its diameter is 78-288 μm, the maximum length is 2 cm, and the required blood volume is about 200-500 μL.

[0061] In some embodiments, a pressure display 8, a time display 9 and a flow display 10 are provided on the support platform 3. The pressure display 8, the time display 9 and the flow display 10 are all connected to the detection system. The pressure display 8 is used to display the working pressure of the vacuum pump 7. The time display 9 is used to display the time from the start of the test to the detection of the flow rate flowing into each second blood reservoir 6 being zero. The flow display 10 is used to display the flow rate of whole blood entering each second blood reservoir 6.

[0062] This embodiment makes it easy for staff to record test process data.

[0063] In some embodiments, the capillary tube 4 and the second blood reservoir 6 are connected via a terminal connection tube 16, which is provided with a flow sensor 15. A vacuum pump pressure detection sensor 17 is provided within the vacuum pump 7. The capillary tube 4 and the terminal connection tube 16 are plug-connected.

[0064] The present invention uses specific examples to illustrate the principles and implementation methods of the present invention. The above examples are only intended to help understand the method and core concept of the present invention. At the same time, those skilled in the art will find that the specific implementation methods and application scopes may vary based on the concept of the present invention. In summary, the contents of this specification should not be construed as limiting the present invention.

Claims

1. A multi-parameter thrombosis risk detector, characterized by: The system comprises several test units, wherein the test units include: A first blood storage tube, used for storing whole blood samples; At least two capillaries are provided, at least one of which is a test tube and at least one is a control tube; the inner wall of the test tube is coated with collagen, and the inner wall of the control tube is coated with serum albumin; the test tube is used to circulate whole blood and provide space for thrombus formation, and the two ends of the capillary are respectively an inlet end for inputting whole blood into the capillary and an outlet end for outputting whole blood in the capillary, and the inlet end of the capillary is connected to the first blood reservoir; The second blood reservoirs are provided in the same number as the capillaries and are arranged one-to-one, the second blood reservoirs being connected to the outlet ends of the capillaries and being used to store whole blood flowing out of the capillaries; the second blood reservoirs have a scale on their walls for indicating the volume of the liquid therein; a driving system, configured to drive the whole blood in the first blood reservoir to flow into the capillary tube and then into the second blood reservoir for storage; The detection system is capable of at least detecting the flow rate of whole blood entering each of the second blood reservoirs and the time length from the start of the test to the flow rate detection reaching zero.

2. The multi-parameter thrombosis risk detector according to claim 1, characterized in that: The driving system is a vacuum pump. The top end of the second blood reservoir is connected to the negative pressure port of the vacuum pump, and the bottom end is connected to the outlet end of the capillary tube. The vacuum pump can use a stable negative pressure to drive the whole blood in the first blood reservoir to flow into the capillary tube and then into the second blood reservoir for storage.

3. The multi-parameter thrombosis risk detector according to claim 2, characterized in that: The first blood storage tube is a blood collection tube, and the capillary tube is a capillary glass tube.

4. The multi-parameter thrombosis risk detector according to claim 1, characterized in that: Each of the test units is provided with a control tube and a plurality of test tubes.

5. The multi-parameter thrombosis risk detector according to claim 1, characterized in that: One of the first blood reservoirs in the same test unit can be connected to the inlet ends of a plurality of the capillaries via a blood perfusion connecting tube, and the blood perfusion connecting tube is provided with a blood buffer zone having a larger cross-sectional area than the blood perfusion connecting tube.

6. The multi-parameter thrombosis risk detector according to claim 2, characterized in that: The plurality of second blood storage tubes are all vertically arranged, and the top ends are connected to the negative pressure port of the vacuum pump through the same vacuum pump connecting tube.

7. The multi-parameter thrombosis risk detector according to claim 3, characterized in that: A support platform is also provided, which is used to support the first blood storage tube, capillary tube, second blood storage tube and drive system. The capillary tube is arranged horizontally and the first blood storage tube is arranged vertically. A blood collection tube placement port connected to the inlet end of the capillary tube is constructed on the support platform, and the blood collection tube opening is inserted into the blood collection tube placement port with the opening facing downward.

8. The multi-parameter thrombosis risk detector according to claim 7, characterized in that: A plurality of the test units are provided, and the support platform is configured with the same number of blood collection tube placement ports as the test units. One test unit corresponds to one blood collection tube placement port, and the plurality of test units share one driving system.

9. The multi-parameter thrombosis risk detector according to claim 1, characterized in that: The cross section of the capillary is circular, elliptical or rectangular.

10. The multi-parameter thrombosis risk detector according to claim 7, characterized in that: A pressure display, a time display, and a flow display are provided on the support platform. The pressure display, the time display, and the flow display are all connected to the detection system. The pressure display is used to display the working pressure of the vacuum pump. The time display is used to display the time from the start of the test to the detection of the flow rate flowing into each second blood reservoir being zero. The flow display is used to display the flow rate of whole blood entering each second blood reservoir.

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