Composition and medicine for treating type 2 diabetes mellitus as well as preparation method and application of composition and medicine

Abstract

The invention provides a composition and a medicine for treating type 2 diabetes mellitus as well as a preparation method and application of the composition and the medicine, and belongs to the technical field of traditional Chinese medicine compositions. The composition is prepared from the following raw materials in parts by weight: 3 to 10 parts of radix puerariae, 2 to 8 parts of rhizoma polygonati, 1 to 3 parts of poria cocos and 1 to 2.5 parts of oyster. In the invention, the kudzuvine root exerts the effects of relieving exterior syndrome, abating fever, raising yang and stopping diarrhea, the rhizoma polygonati exerts the effects of tonifying qi, tonifying kidney, strengthening spleen and moistening lung, the poria cocos has the effects of reducing blood sugar and fat, and the oyster has the effects of nourishing yin, suppressing yang, calming liver and inducing astringency. The composition disclosed by the invention not only can reduce the blood glucose level of a patient suffering from the type 2 diabetes mellitus and control complications, but also can recover normal pancreas islet functions, get rid of dependence on western medicines and insulin and realize reversion of the type 2 diabetes mellitus.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine compositions, and in particular relates to a composition for treating type 2 diabetes, a medicine, a preparation method and an application thereof. Background Art

[0002] Diabetes is a chronic disease characterized by hyperglycemia, caused by absolute or relative insulin deficiency and impaired utilization. It is categorized into type 1 diabetes, type 2 diabetes, and gestational diabetes. Type 2 diabetes is a chronic disease caused by insufficient or inefficient insulin utilization. Currently, treatment for type 2 diabetes is primarily focused on controlling blood sugar levels. As the disease progresses, patients require lifelong medication and insulin injections, leading to drug dependency. Summary of the Invention

[0003] The present invention aims to provide a composition, a medicine, a preparation method and an application for treating type 2 diabetes. The composition of the present invention can not only lower the blood sugar level of patients with type 2 diabetes, but also restore normal pancreatic function, thereby eliminating dependence on Western medicine and insulin.

[0004] The invention provides a composition for treating type 2 diabetes, comprising the following raw materials in parts by weight: 3-10 parts of kudzu root, 2-8 parts of polygonatum, 1-3 parts of poria and 1-2.5 parts of oyster.

[0005] Preferably, the composition comprises the following raw materials in parts by weight: 10 parts of Pueraria root, 8 parts of Polygonatum sibiricum, 3 parts of Poria cocos and 2.5 parts of oyster.

[0006] The present invention also provides a method for preparing the composition described in the above scheme, comprising the following steps:

[0007] The raw materials of the composition are mixed with an ethanol aqueous solution and extracted to obtain an extract.

[0008] Preferably, the volume fraction of ethanol in the ethanol aqueous solution is 70%.

[0009] Preferably, after obtaining the extract, the process further comprises concentrating and drying the extract in sequence to obtain dry powder; after obtaining the dry powder, the process further comprises granulating the dry powder and / or preparing it into tablets.

[0010] The present invention also provides use of the composition described in the above scheme or the composition prepared by the preparation method in preparing a drug for treating type 2 diabetes.

[0011] The present invention also provides a drug for treating type 2 diabetes, the active ingredients of which include a composition for treating type 2 diabetes and pharmaceutically acceptable excipients; the composition for treating type 2 diabetes is the composition described in the above scheme or the composition prepared by the preparation method; the dosage form of the drug is a solid oral preparation.

[0012] Preferably, the solid oral preparation comprises at least one of powder, tablet and granule.

[0013] Preferably, in addition to the composition, the active ingredients of the medicine also include other Western medicines and / or Chinese medicines that are effective in treating type 2 diabetes; or, the composition is the only active ingredient of the medicine.

[0014] Preferably, the drug further includes instructions; the instructions record at least one of the following: how to use the drug, adverse reactions, dietary management requirements during medication, and work and rest exercise management requirements.

[0015] The present invention provides a composition for treating type 2 diabetes, comprising the following raw materials in parts by weight: 3-10 parts of Pueraria root, 2-8 parts of Polygonatum sibiricum, 1-3 parts of Poria cocos, and 1-2.5 parts of Oyster. In the present invention, Pueraria root has the effects of dispelling exterior pathogens, reducing fever, raising yang and stopping diarrhea, and improving symptoms such as dry mouth and tongue, short and dark urine, and diarrhea by promoting the clear yang qi of the spleen and stomach; Pueraria root contains glycogenin, which has the effect of regulating blood sugar levels and can also promote the repair of damaged pancreatic cells, helping to restore normal pancreatic islet function. In the present invention, Polygonatum sibiricum has the effects of replenishing qi and benefiting the kidney, strengthening the spleen and moistening the lungs; Polygonatum sibiricum replenishes the lungs, treats yin deficiency and lung dryness, and can produce fluid to relieve lung dryness, thereby alleviating the thirst of patients with type 2 diabetes; Polygonatum sibiricum replenishes the kidneys in the lower part of the body, treats kidney deficiency and essence deficiency, and can treat kidney deficiency type diabetes; Polygonatum sibiricum can also replenish essence and blood, and suppress the hyperactivity of appetite in patients with type 2 diabetes. In the present invention, Poria has the efficacy of lowering blood sugar and reducing fat, and is used to treat dysuria, edema, spleen deficiency, insomnia and forgetfulness, turbid spermatorrhea and impotence and premature ejaculation caused by type 2 diabetes. In the present invention, oyster has the efficacy of nourishing yin and suppressing yang, calming the liver and astringing; oyster can promote metabolism, thereby alleviating the cold hands and feet of diabetic patients; oyster can also help sleep, which is beneficial to improving the symptoms of palpitations, convulsions, insomnia, and sleeplessness in diabetic patients. The raw materials of the composition of the present invention can synergistically exert the efficacy of detoxification and silt removal, dampness and cold removal, and fat removal and spleen nourishment, stimulate the body's own self-regulation ability, coordinate yin and yang, adjust the circular movement of qi, activate and repair dormant and damaged pancreatic beta cells through fat removal and detoxification, enable pancreatic beta cells to work normally and effectively divide, and make the secretion level of insulin reach the amount required by the human body. Therefore, the composition of the present invention can not only lower the blood sugar level of patients with type 2 diabetes and control complications, but also restore normal pancreatic function, get rid of dependence on Western medicine and insulin, and achieve reversal of type 2 diabetes.

[0016] Furthermore, the raw materials in the composition of the present invention are all herbal and medicinal and edible raw materials. Through the power of natural herbs, according to the correspondence between heaven and man, the harmony between man and nature is adjusted, thereby improving insulin resistance, promoting blood sugar balance, and reducing the side effects of chemically synthesized drugs. The composition of the present invention not only sets a precedent for treating type 2 diabetes using only medicinal and edible raw materials, filling the gap between traditional Chinese medicine theory and modern medical research, but also provides a safe, effective, and low-cost alternative or complementary treatment drug, providing more treatment options for patients with type 2 diabetes, especially those seeking natural therapies or those who cannot tolerate the side effects of traditional Western medicine.

[0017] It has been verified that patients with type 2 diabetes who take the composition of the present invention can balance their glycosylated hemoglobin levels in 4 to 6 months and can achieve recovery in 1 to 3 years. Using the composition of the present invention to treat type 2 diabetes as early as possible can improve the effectiveness of treating type 2 diabetes, reduce the complications caused by type 2 diabetes, and play an important role in improving the quality of life and quality of life of patients with type 2 diabetes. The composition of the present invention is a key measure to cope with the prevalence of type 2 diabetes, and is also an important part of scientific and technological progress, cultural exchange and health promotion. It not only brings new hope to patients with type 2 diabetes, but also provides clearer evidence-based medicine for the clinical treatment of type 2 diabetes, which can further promote the pace of modernization of traditional Chinese medicine and promote the innovative development of the integrated Chinese and Western medicine treatment model for type 2 diabetes. DETAILED DESCRIPTION

[0018] The invention provides a composition for treating type 2 diabetes, comprising the following raw materials in parts by weight: 3-10 parts of kudzu root, 2-8 parts of polygonatum, 1-3 parts of poria and 1-2.5 parts of oyster.

[0019] In the present invention, the composition comprises 3 to 10 parts by weight of Pueraria root. Pueraria root, in this invention, has the effects of dispelling exterior pathogens, reducing fever, and promoting yang and stopping diarrhea, significantly lowering blood sugar. By promoting the spleen and stomach's clearing yang qi, it improves symptoms such as dry mouth and tongue, short and dark urine, and persistent diarrhea. Furthermore, Pueraria root contains quercetin, which regulates blood sugar levels, promotes the repair of damaged pancreatic cells, protects the kidneys, and strengthens renal function. Pueraria root can also effectively prevent retinopathy caused by type 2 diabetes and enhance the body's immune system. Furthermore, chronically elevated blood sugar levels in patients with type 2 diabetes can lead to various complications, including cardiovascular disease. Pueraria root contains puerarin and flavonoids, which have lipid-lowering effects, dilate blood vessels, and lower serum cholesterol and triglycerides, helping to lower blood sugar and reduce the incidence of cardiovascular and cerebrovascular diseases. It also activates blood vessels, softens blood vessel walls, helps enhance smooth muscle elasticity, reduces intravascular deposition, and effectively improves blood circulation and increases blood flow.

[0020] In the present invention, the composition comprises 2 to 8 parts of Polygonatum sibiricum by weight. Polygonatum sibiricum exhibits the effects of tonifying qi and benefiting the kidneys, strengthening the spleen and moistening the lungs. Typical symptoms of type 2 diabetes mellitus, namely, upper, middle, and lower enervation, correspond to the upper, middle, and lower enervation of the human body. The primary pathogenesis of upper enervation is lung heat and lobe scorching. The lungs generate more heat than normal, causing lung lobes to wilt and develop pathologically. Therefore, patients with type 2 diabetes must constantly drink water to moisten the lungs, clinically manifesting as thirst and thirst, i.e., polydipsia. Polygonatum sibiricum can tonify qi and nourish yin, strengthen the spleen and moisten the lungs, and benefit the kidneys. It tonifies the lungs in the upper energizer, treats yin deficiency and lung dryness, and promotes fluid production to alleviate lung dryness, thus alleviating the thirst syndrome of diabetes. Middle enervation refers to increased appetite and frequent hunger. Polygonatum tonifies the spleen and stomach in the middle energizer, treating spleen and stomach qi deficiency. Polyuria, a symptom that occurs in the lower energizer of type 2 diabetes, is primarily caused by elevated blood sugar levels, which lead to high sugar concentrations in the primary urine, increased urine osmotic pressure, and water absorption, resulting in polyuria in type 2 diabetes. Polygonatum sibiricum nourishes the kidneys in the lower abdomen, treating kidney deficiency and essence deficiency, and is effective in treating kidney deficiency-type diabetes. In the early stages of type 2 diabetes, most patients are obese, often with a phlegm-damp constitution. This disrupted water metabolism leads to an imbalance of yin and yang. Later, a series of physiological and pathological changes deplete the body's internal body fluids, leading to the development of polydipsia and gradual emaciation. Polygonatum sibiricum can also nourish the five internal organs. Complications of type 2 diabetes also include kidney disease. Long-term type 2 diabetes patients often experience fatigue, decreased energy, and memory, manifesting as qi and blood deficiency and kidney deficiency. At this stage, the body needs to eat more to replenish these deficiencies, leading to increased appetite. Polygonatum sibiricum helps promote a sense of fullness, replenishes essence and blood, and suppresses excessive appetite.

[0021] In the present invention, the composition comprises 1 to 3 parts of Poria cocos by weight; Poria cocos has the efficacy of lowering blood sugar and reducing fat, and is used to treat dysuria, edema, spleen deficiency, insomnia and forgetfulness, spermatorrhea and leucorrhea, and impotence and premature ejaculation caused by type 2 diabetes.

[0022] In the present invention, the composition includes 1 to 2.5 parts of oysters by weight; in the present invention, oysters have the effects of nourishing yin and suppressing yang, calming the liver and astringing; oysters can promote metabolism, thereby alleviating the cold hands and feet of diabetic patients; complications caused by type 2 diabetes also include neuropathy, and oysters have a sleep-inducing effect, which is beneficial to improving symptoms such as palpitations, convulsions, insomnia, and sleeplessness in diabetic patients.

[0023] As an embodiment, the composition includes the following raw materials in parts by weight: 10 parts of Pueraria root, 8 parts of Polygonatum sibiricum, 3 parts of Poria cocos and 2.5 parts of oyster; further, the composition is composed of the following raw materials in parts by weight: 10 parts of Pueraria root, 8 parts of Polygonatum sibiricum, 3 parts of Poria cocos and 2.5 parts of oyster.

[0024] The present invention also provides a method for preparing the composition described in the above scheme, comprising the following steps: mixing the raw materials of the composition with an ethanol aqueous solution, performing extraction, and obtaining an extract.

[0025] As an embodiment, the volume fraction of ethanol in the ethanol aqueous solution is 70%.

[0026] As an embodiment, the mass volume ratio of the raw material of the composition and the ethanol aqueous solution is 1g: (34-40)mL; the extraction includes reflux extraction; the number of reflux extractions is 5 times, and the time of each reflux extraction is 1.5h; after the reflux extraction, filtering, combining the filtrate, and obtaining an extract.

[0027] As an embodiment, after obtaining the extract, the method further includes concentrating and drying the extract in sequence to obtain a dry powder, which is named Gehuang Huyi powder; the concentration includes concentration under reduced pressure to an extract state; the drying includes drying at normal pressure; the temperature of the normal pressure drying is 70°C; after the drying, the dried material is sieved, and the aperture of the sieve is 100 mesh.

[0028] As an embodiment, after obtaining the dry powder, the dry powder is further granulated and / or made into tablets; the reagent used for the granulation includes a PVP alcohol solution with a mass fraction of 10%; the solvent of the PVP alcohol solution is ethanol; after granulation, the process further includes drying at 55°C, granulating, passing through a 14-mesh sieve, mixing and tableting to obtain tablets.

[0029] The present invention also provides use of the composition or the composition prepared by the preparation method in preparing a drug for treating type 2 diabetes.

[0030] As an embodiment, the treatment of type 2 diabetes includes at least one of the following: lowering blood sugar, balancing glycated hemoglobin levels, controlling complications caused by type 2 diabetes and restoring pancreatic function; the complications caused by type 2 diabetes include at least one of cardiovascular disease, kidney disease and neuropathy.

[0031] The present invention also provides a drug for treating type 2 diabetes, comprising a composition for treating type 2 diabetes and a pharmaceutically acceptable excipient; the composition for treating type 2 diabetes is the composition described in the above scheme or the composition prepared by the preparation method; the drug is in the form of a solid oral preparation; compared to liquid preparations, solid oral preparations have better absorption rates, more stable, controllable, safer, and more pronounced efficacy, and less variability in efficacy among patients. Furthermore, liquid preparations produce significant pharmacological reactions, while solid preparations produce virtually no pharmacological reactions.

[0032] As an embodiment, the solid oral preparation includes at least one of powder, tablet and granule, and is further a tablet.

[0033] As an embodiment, the drug also includes instructions; the instructions record at least one of the following contents: the method of use of the drug, adverse reactions, dietary management requirements during medication, and work and rest exercise management requirements; the method of use of the drug includes: 3 times a day, 6 tablets each time, patients with gastrointestinal discomfort, take it with meals, patients without gastrointestinal discomfort, take it before meals; the adverse reactions include: the initial use of the drug will regulate the function of the internal organs and resolve phlegm and blood stasis, etc., and symptoms such as nausea, itching, peeling, abdominal distension, fatigue, etc. may occur. At this time, the symptoms are also the self-regulation reactions of the internal organs.

[0034] As an implementation method, the dietary management requirements record foods that are suitable for consumption and foods that are not suitable for consumption; the foods that are suitable for consumption include one or more of the following: vegetables, soy products, fungi, meat, fruits and seasonings; the vegetables include cabbage, cauliflower, cucumber, spinach, wax gourd, eggplant, cabbage, zucchini, onion, loofah, bitter gourd, rapeseed, toon, garlic sprouts, beans, tomatoes (raw), garland chrysanthemum, water spinach, bamboo shoots, cabbage, sweet potato leaves, cauliflower, green peppers (non-spicy green peppers), white radish, water radish, lettuce, shepherd's purse, bean sprouts, mung bean sprouts, bok choy, bok choy, broccoli, chayote, cauliflower, edamame, coriander, celery (some patients with gastrointestinal dysfunction and kidney disease should not eat them) and One or more of green beans; the soy products include one or more of tofu, tofu skin, dried tofu and soy milk; the fungi include shiitake mushrooms and / or mushrooms; people with diabetic nephropathy, high uric acid and slow protein metabolism should use soy products and fungi with caution; the meat includes one or more of chicken, duck, fish, shrimp, crab, beef, mutton and pork; the meat is further made into soup for consumption; the fruit includes one or more of avocado, yacon (forbidden for people with cold constitution), kiwi, grapefruit, apple and cherry; only one kind of fruit can be eaten per day, cooked and taken on an empty stomach at noon, and no fruit can be eaten within 0 to 4 months of taking medication; the seasoning includes one or more of oil, salt, MSG, onion, ginger and garlic.

[0035] As an embodiment, the taboo foods include: one or more of potatoes, sweet potatoes, lotus roots, pumpkins, carrots, leeks, refined rice, refined noodles, jelly, rice noodles, vermicelli, corn and condiments; the condiments include one or more of chicken essence, seasoned vinegar, blended soy sauce and spicy and fragrant seasonings; the spicy and fragrant seasonings include one or more of pepper, black pepper, Sichuan pepper and aniseed.

[0036] As an implementation method, the dietary management requirements also include that soups and foods should be light.

[0037] As an implementation method, the work and rest exercise management requirements include:

[0038] 1. Go to bed between 9:00 PM and 10:00 PM, and meditate for 10 to 30 minutes before bed.

[0039] 2. Get up between 5:00 and 6:00 am and measure fasting blood sugar;

[0040] 3. Drink 200mL of water at a temperature of 28-30℃ after getting up;

[0041] 4. Morning exercise; exercise duration is 30 minutes to 1 hour, and the exercise items include one or more of Tai Chi, yoga, Yi Jin Jing, Ba Duan Jin, running, and cycling; the heart rate of running and cycling should reach 170 minus the patient's age per minute;

[0042] 5. Breakfast: 7:00-9:00, rich food, high in calories; measure blood sugar 2 hours after the first bite of food;

[0043] 6. Lunch: Eat until you are full, and try to eat vegetarian food. Measure blood sugar 2 hours after the first bite of food.

[0044] 7. Lunch break: Take a short break from 11:00 to 13:00, not exceeding 30 minutes;

[0045] 8. Dinner: Eat less or no dinner. Cook vegetables when hungry. Measure blood sugar 2 hours after the first bite of food.

[0046] 9. Daily mobile phone holding time ≤ 1h / day;

[0047] 10. Maintain great love, kindness, tolerance and gratitude every day.

[0048] In the present invention, dietary management and daily exercise management during medication are beneficial to controlling diet and regulating daily routine, reducing interference with the progress of visceral repair, enabling the drug to repair the viscera to the maximum extent, facilitating regular reduction and suspension of oral hypoglycemic drugs and insulin, helping to stabilize blood sugar and shorten the medication cycle.

[0049] To further illustrate the present invention, the following detailed description of a composition, medicine, preparation method and application for treating type 2 diabetes provided by the present invention is given in conjunction with examples, but they should not be construed as limiting the scope of protection of the present invention.

[0050] Example 1

[0051] 1. Ingredients: Pueraria root 10g, Polygonatum 8g, Poria 3g and Oyster 2.5g.

[0052] 2. Preparation method: ethanol reflux extraction

[0053] The specific method is as follows:

[0054] Mix kudzu root, polygonatum, poria and oyster, and add 40 times the amount of 70% ethanol aqueous solution with a mass volume ratio (g:mL), extract 5 times, each time for 1.5 hours, filter, combine the filtrate, concentrate under reduced pressure to an extract, dry at normal pressure at 70°C, pass through a 100-mesh sieve to obtain fine powder, granulate with a 10% PVP ethanol solution by mass fraction, dry at 55°C, granulate, pass through a 14-mesh sieve, mix, and tablet.

[0055] Example 2

[0056] 1. Ingredients: Pueraria root 3g, Polygonatum 2g, Poria 1g and Oyster 1g.

[0057] The preparation method is the same as that of Example 1.

[0058] In the following case, the patient underwent anti-diabetic management by taking the tablets prepared in Example 1, three times a day, six tablets per time. Patients with gastrointestinal discomfort took the tablets with meals, while those without gastrointestinal discomfort took the tablets before meals. Dietary management and exercise management were also performed during the treatment period.

[0059] Dietary management requirements are as follows:

[0060] Suitable foods: vegetables, soy products, fungi, meat, fruits and seasonings; vegetables include cabbage, cauliflower, cucumber, spinach, winter melon, eggplant, kale, zucchini, onion, loofah, bitter melon, rapeseed, Chinese toon, garlic sprouts, beans, tomatoes (raw), garland chrysanthemum, water spinach, bamboo shoots, cabbage, sweet potato leaves, cauliflower, green peppers (non-spicy green peppers), white radish, water radish, lettuce, shepherd's purse, bean sprouts, mung bean sprouts, bok choy, pak choy, broccoli, chayote, cauliflower, edamame, cilantro, celery (some patients with gastrointestinal dysfunction and kidney disease should avoid eating) and green beans Soy products include tofu, tofu skin, dried tofu, and soy milk; fungi include shiitake mushrooms and mushrooms; those with diabetic nephropathy, high uric acid, and slow protein metabolism should use soy products and fungi with caution; meat includes chicken, duck, fish, shrimp, crab, beef, lamb, and pork; meat should be eaten in soups; fruits include avocado, yacon (not for those with a cold constitution), kiwi, grapefruit, apples, and cherries; only one kind of fruit should be consumed daily, cooked and consumed on an empty stomach at noon; fruit should not be consumed if taking medication for 0-4 months; seasonings include oil, salt, MSG, onion, ginger, and garlic; soups should be light.

[0061] Foods to avoid: potatoes, sweet potatoes, lotus root, pumpkin, carrots, leeks, refined rice, refined noodles, jelly, rice noodles, vermicelli, corn and condiments; condiments include chicken essence, seasoned vinegar, blended soy sauce and spicy seasonings; spicy seasonings include pepper, black pepper, Sichuan peppercorns and aniseed.

[0062] The work and rest exercise management is as follows:

[0063] 1. Go to bed between 9:00 PM and 10:00 PM, and meditate for 10 to 30 minutes before bed.

[0064] 2. Get up between 5:00 and 6:00 am and measure fasting blood sugar;

[0065] 3. Drink 200mL of water at a temperature of 28-30℃ after getting up;

[0066] 4. Morning exercise; exercise duration is 30 minutes to 1 hour, and the exercise items include one or more of Tai Chi, yoga, Yi Jin Jing, Ba Duan Jin, running, and cycling; the heart rate of running and cycling should reach 170 minus the patient's age per minute;

[0067] 5. Breakfast: 7:00-9:00, rich food, high in calories; measure blood sugar 2 hours after the first bite of food;

[0068] 6. Lunch: Eat until you are full, and try to eat vegetarian food. Measure blood sugar 2 hours after the first bite of food.

[0069] 7. Lunch break: Take a short break from 11:00 to 13:00, not exceeding 30 minutes;

[0070] 8. Dinner: Eat less or no dinner. Cook vegetables when hungry. Measure blood sugar 2 hours after the first bite of food.

[0071] 9. Daily mobile phone holding time ≤ 1h / day;

[0072] 10. Maintain great love, kindness, tolerance and gratitude every day.

[0073] Case 1

[0074] Niu, a female from Huaibei, Anhui Province, took 20 units of insulin and two Western medicines before taking the medicine prepared in Example 1. She stopped taking the 20 units of insulin and two Western medicines after 3 days of medication. After 8 days of medication, her fasting blood pressure was 7.2 and her postprandial blood pressure was 6.0.

[0075] Case 2

[0076] Han, a male from Huaibei, Anhui Province, had a history of diabetes for 3 years, heart disease for 13 years, hypertension for 23 years, and cerebral infarction for 5 years before taking the drug prepared in Example 1. He also had hypothyroidism and took 17 Western medications daily. His pre-meal blood sugar was 9.55, and his urine glucose level was 3+, urobilinogen+, ketone bodies+, and bilirubin+. He stopped taking the anti-diabetic medication after 3 days of glucose management. After one month of treatment, his pre-meal blood sugar dropped from 9.55 to 5.9-6.1 on a fasting basis, and his urine glucose levels were 3+, urobilinogen+, ketone bodies+, and bilirubin+, all turning negative.

[0077] Case 3

[0078] The cell bank cooperative patient Mr. Liu, male, aged 60, was included in the anti-sugar management on March 10, 2024. He had a history of diabetes for 17 years before taking the medicine prepared in Example 1, 20 units of insulin and 2 western medicines; after 3 days of treatment, all 20 units of insulin and 2 western medicines were discontinued. After one and a half months of treatment, the fasting blood sugar was 5.0-5.2, and the postprandial blood sugar was less than 7. The effect was significant and he has now recovered. The total conditioning time was 5 months.

[0079] Case 4

[0080] A cell bank cooperative patient was included in anti-sugar management on April 10, 2024. Before taking the medicine prepared in Example 1, he had a history of diabetes for more than 10 years and took 18 units of insulin and 2 western medicines. After 3 days of treatment, all insulin and 2 western medicines were discontinued. After 15 days of anti-sugar management, the fasting blood sugar was 5-6.4 and 7.1 after meals. The effect was significant and the patient has now recovered. The total conditioning time was 4 months.

[0081] Case 5

[0082] Li, treatment time is from January to May 2024. Before taking the medicine prepared in Example 1, on January 5, 2024, the glycated hemoglobin was 10.3, on January 5, 2024, the occult blood was +, the white blood cell was 1+, the urine glucose was 1+, the urine protein was 1+, the urine microalbumin was greater than 0.15, the ketone body was +, the urine specific gravity was 1.029, the pH was 6.0, the white blood cell was 181, the suspected cocci were 218, the hyaline cast was 1, the white blood cell (high magnification) was 33, the red blood cell (high magnification) was 3, the squamous epithelial cells were 28, and the non-squamous epithelial cells were 3. After taking the medicine, on May 17, 2024, the glycated hemoglobin was 6.8, on May 17, 2024, the occult blood was normal, the white blood cells were normal, the urine glucose was normal, the urine protein was normal, the urine microalbumin was normal, the ketone bodies were normal, the urine specific gravity was 1.015, the pH was 6.5, the white blood cells were normal, the suspected cocci were normal, the hyaline casts were normal, the white blood cells (high magnification) were normal, the red blood cells (high magnification) were normal, the squamous epithelial cells were normal, and the non-squamous epithelial cells were normal.

[0083] Case 6

[0084] A 57-year-old female patient from Zhengzhou suffered from diabetic nephropathy. She took two kinds of Western hypoglycemic drugs and injected 30 units of insulin a day. On January 5, 2024, her fasting blood sugar was 16.52, and her postprandial blood sugar was 18-22. After 4 months of anti-diabetic management, her fasting blood sugar was 6.7-7.4 on May 17, 2024, and her postprandial blood sugar was 7.33.

[0085] Case 7

[0086] Huaibei, Liu, male, 78 years old, 20 years of diabetes history, taking three hypoglycemic drugs, a total of 6 tablets a day, 6 years of hypertension history, antihypertensive drug one tablet a day, cerebral infarction, blurred vision, eye swelling, bitter taste in the mouth, a lot of foam in the urine, getting up twice at night, insomnia, waking up at 3 o'clock in the night and having trouble falling asleep. Before taking the medicine prepared in Example 1, on May 22, 2024, a physical examination showed fasting blood sugar of 13.83, diffuse thyroid lesions, thyroid nodules, enlarged bilateral cervical lymph nodes, carotid artery sclerosis, acylated hemoglobin 8.9, C-peptide 4.48; after reverse sugar management, on the morning of June 3, 2024, postprandial blood sugar was 16.3mmol / L, and in the evening, postprandial blood sugar was 12.7mmol / L; on the morning of June 4, 2024, fasting blood sugar was 11.6mm ol / L, morning postprandial blood glucose 13.9mmol / L; fasting blood glucose 13.6mmol / L on June 5, 2024; recheck on August 25, 2024, fasting blood glucose 7.53, C-peptide 2.68; recheck on October 15, 2024, C-peptide 4.04, glycosylated hemoglobin 5.8; recheck on December 24, 2024, C-peptide 3.79, insulin 17.22, glycosylated hemoglobin 5.9, fasting blood glucose 7.78.

[0087] Case 8

[0088] Xining, a diabetic, successfully reversed his sugar levels in 2022 after one year of reverse sugar management and conditioning. He has now stopped taking western medicine and insulin. The overall plan has been in place for more than two years. He has a normal diet and a normal schedule, and his fasting blood sugar is currently 4.8-5.6.

[0089] Case 9

[0090] Xianghe, Wang, 48 years old, male, height 1.81 meters, weight 203 kilograms, has had hypertension for 7 years, taking one antihypertensive drug a day, with high blood pressure of 130 and low blood pressure around 90, blood sugar for 15 years, and taking insulin for 8 years, 16 units in the morning and 20 units in the evening, on an empty stomach, taking two Western medicines to lower blood sugar, a total of two tablets a day, occasional dizziness, dizziness, blurred vision, dry mouth, cold feet, sinus rhythm, loose teeth, 4 of which have been pulled out, foamy urine with a strong odor, getting up twice at night, bowel movements once a day, small amounts, family history, poor sleep quality, liver deficiency fire, cold internal organs, heavy dampness, and lung fire; on April 16, fasting blood sugar was 9.3mmol / L, and blood sugar 2 hours after meal was 15.1mmol / L; on April 17, fasting blood sugar was 7.6mmol / L, and blood sugar 2 hours after meal was 7.6mmol / L; on May 25, fasting blood sugar was 5.0mmol / L, and blood sugar 2 hours after meal was 9.0mmol / L. On November 1, 2024, the urine sugar value was +3 and the C-peptide value was 0.389; on February 18, 2025, the C-peptide value was 2.16 and the urine sugar value was +1.

[0091] Comparative Case 1

[0092] For patients with type 2 diabetes, if they only control their diet and adjust their daily routine without taking the medicine prepared in the embodiment, the reversal effect cannot be achieved and the effect is not good.

[0093] Although the above embodiment provides a detailed description of the present invention, it is only a part of the embodiments of the present invention, not all of the embodiments. People can also obtain other embodiments based on this embodiment without creativity, and these embodiments all fall within the scope of protection of the present invention.

Claims

1. A composition for treating type 2 diabetes, characterized in that: The invention comprises the following raw materials in parts by weight: 3-10 parts of kudzu root, 2-8 parts of polygonatum, 1-3 parts of tuckahoe and 1-2.5 parts of oyster.

2. The composition according to claim 1, characterized in that The composition comprises the following raw materials in parts by weight: 10 parts of kudzu root, 8 parts of polygonatum, 3 parts of poria and 2.5 parts of oyster.

3. The method for preparing the composition according to claim 1 or 2, characterized in that: The following steps are involved: The raw materials of the composition are mixed with an ethanol aqueous solution and extracted to obtain an extract.

4. The preparation method according to claim 3, characterized in that The volume fraction of ethanol in the ethanol aqueous solution is 70%.

5. The preparation method according to claim 3, characterized in that After obtaining the extract, the method further includes concentrating and drying the extract in sequence to obtain dry powder; after obtaining the dry powder, the method further includes granulating the dry powder and / or making it into tablets.

6. Use of the composition according to claim 1 or 2, or the composition prepared by the preparation method according to any one of claims 3 to 5, in the preparation of a medicament for treating type 2 diabetes.

7. A drug for treating type 2 diabetes, characterized in that: The active ingredients include a composition for treating type 2 diabetes and pharmaceutically acceptable excipients; the composition for treating type 2 diabetes is the composition according to claim 1 or 2 or the composition prepared by the preparation method according to any one of claims 3 to 5; the dosage form of the drug is a solid oral preparation.

8. The drug according to claim 7, characterized in that The solid oral preparation includes at least one of powder, tablet and granule.

9. The drug according to claim 7, characterized in that In addition to the composition, the active ingredients of the medicine also include other Western medicines and / or Chinese medicines that are effective in treating type 2 diabetes; or, the composition is the only active ingredient of the medicine.

10. The drug according to claim 7, characterized in that The drug also includes instructions; the instructions record at least one of the following: how to use the drug, adverse reactions, dietary management requirements during medication, and work and rest exercise management requirements.