Traditional Chinese medicine composition for treating ischemic stroke and preparation method and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating ischemic stroke and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from, by weight, 7-10 parts of salvia miltiorrhiza, 10-20 parts of astragalus membranaceus, 4-8 parts of ligusticum wallichii, 2-4 parts of scalded leeches, 2-4 parts of ground beetles, 2-4 parts of gastrodia elata, 4-8 parts of scorpions, 4-8 parts of polygala tenuifolia, 4-8 parts of acorus tatarinowii, 7-10 parts of red peony roots, 4-8 parts of carthamus tinctorius, 4-8 parts of angelica sinensis and 4-8 parts of peach kernels. According to the application, the compatibility structure is rigorous, the primary and secondary effects are clear, through multi-target intervention (antithrombosis, blood flow improvement and nerve protection), the advantages of'compound compatibility and overall adjustment 'of traditional Chinese medicine are embodied, and the aspects of movement, vision, language, cognitive functions and the like are remarkably improved.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition for treating ischemic stroke, and a preparation method and application thereof. Background Art

[0002] Stroke is characterized by high morbidity, high mortality, high disability rate, high recurrence rate and many complications. The medical community lists it as one of the three major diseases that threaten human health, along with coronary heart disease and cancer.

[0003] Traditional Chinese Medicine (TCM) has a long history of treating stroke. Practice has proven that using TCM theory and a combination of syndrome differentiation and medication can achieve effective treatment outcomes, with significant advantages. Chinese invention patent CN107551131B discloses a TCM composition for treating ischemic stroke. The raw materials are astragalus, kudzu root, ligusticum chuanxiong, morinda officinalis, earthworm, ophiopogon, scutellaria, red peony root, and chuanxiong. However, the preparation process involves ethanol extraction, preparation of a clear paste, combination, and spray drying, resulting in a complex and costly process. Summary of the Invention

[0004] In view of the above-mentioned defects, the technical problem to be solved by the present invention is to provide a Chinese medicine composition for treating ischemic stroke and its preparation method and application, so as to solve the problems of complex preparation process and high production cost in the existing technology.

[0005] To this end, the present application provides a traditional Chinese medicine composition for treating ischemic stroke, which is prepared from the following raw materials in parts by weight: 7-10 parts of Salvia miltiorrhiza, 10-15 parts of Astragalus membranaceus, 2-4 parts of Chuanxiong, 1-4 parts of Hirudo scaldoni, 1-4 parts of Eupolyphaga sinensis, 1-4 parts of Gastrodia elata, 2-5 parts of Scorpio, 2-5 parts of Polygala tenuifolia, 2-5 parts of Acorus calamus, 7-10 parts of Paeonia lactiflora, 2-5 parts of Carthamus tinctorius, 2-5 parts of Angelica sinensis, and 2-5 parts of Peach Kernel.

[0006] In the above technical scheme, preferably, the traditional Chinese medicine composition for treating ischemic stroke is prepared from the following raw materials in parts by weight: 8-9 parts of Salvia miltiorrhiza, 10-12 parts of Astragalus membranaceus, 2-4 parts of Chuanxiong, 1-3 parts of Hirudo scaldoni, 1-3 parts of Eupolyphaga sinensis, 1-3 parts of Gastrodia elata, 2-4 parts of Scorpio, 2-4 parts of Polygala tenuifolia, 2-4 parts of Acorus gramineus, 8-9 parts of Paeonia lactiflora, 2-4 parts of Carthamus tinctorius, 2-4 parts of Angelica sinensis, and 2-4 parts of Peach Kernel.

[0007] In the above technical scheme, preferably, the traditional Chinese medicine composition for treating ischemic stroke is prepared from the following raw materials in parts by weight: 8 parts of Salvia miltiorrhiza, 10 parts of Astragalus membranaceus, 4 parts of Chuanxiong, 2 parts of Hirudo scaldii, 2 parts of Eupolyphaga sinensis, 2 parts of Gastrodia elata, 4 parts of Scorpio, 4 parts of Polygala tenuifolia, 4 parts of Acorus gramineus, 8 parts of Paeonia lactiflora, 4 parts of Carthamus tinctorius, 4 parts of Angelica sinensis, and 4 parts of Peach Kernel.

[0008] The present invention also provides a method for preparing the above-mentioned Chinese medicine composition, comprising the following steps:

[0009] According to the formula of the above-mentioned Chinese medicine composition, the raw materials of the corresponding components are weighed and prepared, mixed and crushed into a coarse powder of medicinal materials with a mesh size of 40 to 60;

[0010] The crude powder of medicinal materials is sterilized by moist heat;

[0011] Grinding the coarse medicinal material powder after moist heat sterilization into medicinal material fine powder with a fineness of 100 to 120 mesh, wherein the yield of the medicinal material fine powder is not less than 95.0%;

[0012] The medicinal materials are finely powdered and made into capsules.

[0013] In the above technical method, preferably, the conditions for wet heat sterilization of medicinal material coarse powder are: sterilization temperature 115-117°C, sterilization time 30 minutes, drying time 60-120 minutes, drying vacuum degree 0.06-0.08Mpa, and drying temperature 60°C.

[0014] In the above technical method, preferably, the preparation method of the capsule is as follows:

[0015] The medicinal material fine powder was first batch mixed for 30 minutes;

[0016] Using 5-7% starch slurry as a binder, granulation is performed using a 14-mesh screen, followed by constant temperature drying to control the moisture content of the granules to ≤2.5%;

[0017] The dried particles were crushed into fine particles with a crushing mesh size of 20 mesh;

[0018] The above fine granules were batch mixed with 0.5% magnesium stearate for 30 minutes;

[0019] Use a fully automatic capsule filling machine for capsule filling.

[0020] In the above technical method, preferably, the filling specification of the capsule is 0.4g / capsule.

[0021] The present invention also provides an application of the above-mentioned traditional Chinese medicine composition in preparing medicine for treating ischemic stroke.

[0022] As can be seen from the above technical solutions, the Chinese medicine composition for treating ischemic stroke provided by the present invention, as well as its preparation method and application, solves the problems of the prior art, such as the relatively complex preparation process and high production costs. Compared with the prior art, the present invention has the following beneficial effects:

[0023] The compatibility structure is rigorous, with clear priorities. Through multi-target intervention (anti-thrombosis, improving blood flow, and protecting nerves), it embodies the advantages of traditional Chinese medicine's "compound compatibility and overall regulation", and significantly improves movement, vision, language and cognitive functions. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] To more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces and describes the drawings required for use in the embodiments of the present invention or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present invention, and those skilled in the art can derive other drawings based on these drawings without inventive effort.

[0025] Figure 1 This is a flow chart of a method for preparing a traditional Chinese medicine composition for treating ischemic stroke provided by the present invention. DETAILED DESCRIPTION

[0026] The following will clearly and completely describe the technical solutions of the embodiments of the present invention in conjunction with the accompanying drawings of the embodiments of the present invention. Obviously, the embodiments described below are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts shall fall within the scope of protection of the present invention.

[0027] In order to more clearly explain and illustrate the technical solution and implementation of the present invention, several preferred specific embodiments for implementing the technical solution of the present invention are introduced below.

[0028] It should be noted that the directional words such as "inside, outside", "front, back" and "left, right" in this article are expressed based on the product usage status. Obviously, the use of the corresponding directional words does not constitute a limitation on the scope of protection of this scheme.

[0029] The present application provides a traditional Chinese medicine composition for treating ischemic stroke and a preparation method thereof, which is prepared from the following raw materials in parts by weight: 7-10 parts of salvia miltiorrhiza, 10-15 parts of astragalus, 2-4 parts of chuanxiong, 1-4 parts of scalded leech, 1-4 parts of earthworm, 1-4 parts of gastrodia elata, 2-5 parts of scorpion, 2-5 parts of polygala tenuifolia, 2-5 parts of calamus, 7-10 parts of red peony root, 2-5 parts of safflower, 2-5 parts of angelica sinensis, and 2-5 parts of peach kernel.

[0030] More preferably, it is prepared from the following raw materials in parts by weight: 8-9 parts of Salvia miltiorrhiza, 10-12 parts of Astragalus membranaceus, 2-4 parts of Chuanxiong, 1-3 parts of Hirudo scaldoni, 1-3 parts of Eupolyphaga sinensis, 1-3 parts of Gastrodia elata, 2-4 parts of Scorpio, 2-4 parts of Polygala tenuifolia, 2-4 parts of Acorus calamus, 8-9 parts of Paeonia lactiflora, 2-4 parts of Carthamus tinctorius, 2-4 parts of Angelica sinensis, and 2-4 parts of Peach Kernel.

[0031] The following are several typical examples of the Chinese medicine composition for treating ischemic stroke provided by the present invention:

[0032]

[0033] Among the above-mentioned APIs:

[0034] Salvia miltiorrhiza: It mainly contains diterpene quinones and phenolic acid chemical components, which have pharmacological effects such as protecting vascular endothelial cells, anti-arrhythmia, anti-atherosclerosis, improving microcirculation, protecting the myocardium, inhibiting and relieving platelet aggregation, dilating coronary arteries, increasing coronary flow, and improving the body's tolerance to hypoxia.

[0035] Astragalus: It mainly contains chemical components such as astragalus polysaccharides, saponins, flavonoids and amino acids. It has pharmacological effects such as improving immune function, enhancing antioxidant, anti-radiation, anti-cancer, and protecting cardiovascular, cerebrovascular and liver.

[0036] Chuanxiong: It mainly contains phthalide and its dimers, alkaloids, organic acid phenols, polysaccharides, as well as compounds such as cerebrosides and ceramides. It has pharmacological effects such as promoting blood circulation and removing blood stasis, sedation and analgesia, and inhibiting the release of oxygen free radicals.

[0037] Leeches: The main components of leeches are macromolecular compounds such as hirudin, heparin, histamine, hirudin, and amino acids; they also contain a variety of small molecules such as glycolipids, pteridines, steroids, and carboxylates. They have pharmacological effects such as anti-apoptosis, anti-tumor, anti-coagulant, anti-thrombotic, anti-inflammatory, and anti-fibrotic.

[0038] Eupolyphaga sinensis: It primarily contains protein, volatile oils, fatty acids, amino acids, sterols, and various trace elements. It also contains various fatty and aromatic aldehydes, as well as dichlorobenzene and dimethyl disulfide, ingredients rarely found in other traditional Chinese medicines. It can improve cardiovascular and cerebrovascular function, exhibit significant lipid-regulating effects, and inhibit leukemia cells.

[0039] Gastrodia elata: It mainly contains chemical components such as gastrodin, gastrodinin, β-sitosterol, carotene, citric acid, monomethyl ester, palmitic acid, succinic acid and sucrose; it also contains gastrodia elata polysaccharides, vitamin A, multiple amino acids, trace alkaloids and multiple trace elements, and has pharmacological effects such as analgesia, sedation, anticonvulsant and hypotensive.

[0040] Scorpion: It mainly contains scorpion toxin, trimethylamine, taurine, betaine, cholesterol, and various amino acids. It has pharmacological effects such as analgesia, anti-inflammatory, anti-cancer, anti-epileptic, anticonvulsant, anticoagulant, antibacterial, growth promotion, and immunity enhancement.

[0041] Polygala: It mainly contains triterpenoid saponins, sugar esters, and xanthocyanins, as well as small amounts of alkaloids, coumarins, and lignin. It has pharmacological effects such as anti-dementia, brain protection, sedation, anticonvulsant, antidepressant, expectorant, antitussive, and cardiovascular protection.

[0042] Acorus calamus: It mainly contains chemical components such as volatile oils, alkaloids, quinones, amino acids and sugars. It has pharmacological effects such as sedation, anticonvulsant, improvement of memory recall loss, antitussive and expectorant, antispasmodic, antibacterial, antiarrhythmic, lipid-lowering, orifice-opening, and anti-tumor.

[0043] Red Peony Root: It mainly contains monoterpene glycosides, phenols, polysaccharides and other chemical components, and has pharmacological effects such as anti-tumor, anti-coagulant, anti-thrombotic, anti-lipid, anti-atherosclerotic, and venous dilation.

[0044] Safflower: It mainly contains chemical components such as flavonoids, spermidine, lignans, etc., which have pharmacological effects such as dilating blood vessels, increasing blood flow, improving microcirculation and inhibiting platelet aggregation.

[0045] Angelica: It mainly contains chemical components such as phthalide compounds, coumarins, organic acids, amino acids, polysaccharides, etc. It has pharmacological effects such as promoting hematopoietic function, anti-thrombosis, lowering blood lipids, anti-myocardial ischemia, anti-arrhythmia, regulating uterine smooth muscle function, and regulating immune function;.

[0046] Peach kernel: It mainly contains chemical components such as lipids, glycosides, amino acids, proteins and volatile oils. It has anticoagulant and strong hemolytic effects, and can improve blood flow blockage and blood circulation disorders.

[0047] The formula of the present invention, through multi-target intervention (anti-thrombosis, improving blood flow, protecting nerves), embodies the advantages of traditional Chinese medicine's "compound compatibility and overall regulation" and is more targeted than a single blood-activating and stasis-removing formula. Specifically:

[0048] 1. The combination structure is rigorous and the priorities are clear.

[0049] 1. Monarch medicine (core medicine group).

[0050] Danshen + Huangqi: Invigorate Qi and activate blood circulation, addressing both the symptoms and the root cause. Danshen invigorates blood circulation, dissolves blood stasis, and relieves pain; Huangqi replenishes Qi and raises Yang, promoting blood circulation without harming the body. The two synergistically improve Qi deficiency and blood stasis.

[0051] Chuanxiong + scalded leeches + Eupolyphaga: Strong blood-clearing and blood-stasis-dispelling properties. Chuanxiong is a "blood-invigorating qi medicine," ascending to the head; leeches and Eupolyphaga are insect-based medicines that remove blood stasis from the meridians, specifically targeting the long-term blood stasis that enters the meridians during stroke.

[0052] 2. Assistant medicine (auxiliary medicine group).

[0053] Quanxie + Gastrodia elata: Calming wind and unblocking meridians. Quanxie searches for wind and clears meridians, while Gastrodia elata calms the liver and calms wind, together treating dizziness and limb numbness caused by wind and phlegm.

[0054] Red Peony Root + Safflower + Peach Kernel + Chinese Angelica: Enhance blood circulation and blood stasis removal. Red Peony Root cools blood and disperses blood stasis, Safflower and Peach Kernel break up blood and dissipate blood stasis, while Chinese Angelica invigorates blood circulation and replenishes blood, removing stasis and promoting new blood.

[0055] 3. Auxiliary drugs (harmony drug group).

[0056] Polygala tenuifolia + Acorus calamus: Resolves phlegm, opens the orifices, refreshes the mind and improves intelligence. It is used to treat speech impairment and mental disturbance caused by phlegm blocking the orifices after a stroke.

[0057] Angelica: It also has an adjuvant effect, replenishing blood to prevent blood-activating drugs from damaging yin blood.

[0058] 2. Pharmacological support.

[0059] Improve microcirculation: Salvia miltiorrhiza, Chuanxiong and Safflower can dilate blood vessels and inhibit platelet aggregation.

[0060] Neuroprotection: Astragalus polysaccharides and gastrodin can alleviate cerebral ischemia-reperfusion injury.

[0061] Thrombolytic and anticoagulant: Hirudin (leech) is a natural anticoagulant, and the ground beetle contains fibrinolytic active ingredients.

[0062] Promote nerve repair: Polygala tenuifolia and Acorus calamus promote the release of acetylcholine and improve cognitive function.

[0063] The present invention also provides a method for preparing the above-mentioned Chinese medicine composition for treating ischemic stroke, comprising the following steps:

[0064] Step 110: weighing the raw medicinal materials.

[0065] According to the formula of the above-mentioned Chinese medicine composition, the names and quantities of the thirteen raw medicinal materials are reviewed and then weighed.

[0066] Step 120, crushing into coarse powder.

[0067] The above thirteen medicinal materials were crushed into 40-60 mesh coarse medicinal powder.

[0068] Step 130: sterilize the crude medicinal material powder by moist heat.

[0069] Place the above-mentioned crude medicinal material powder onto stainless steel trays, label them, and place them in a sterilizer. Set the temperature between 115 and 117°C for 30 minutes. After sterilization, close the air inlet valve and allow the temperature to cool naturally. When the pressure reaches zero, open the vacuum valve and the interlayer air inlet valve to maintain the temperature in the cabinet at 60°C. Vacuum dry for 60 to 120 minutes, with a drying vacuum of -0.06 to -0.08 MPa. Once the crude medicinal material powder is dry, remove it from the oven.

[0070] Step 140: finely crush.

[0071] The coarse medicinal material powder after the moist heat sterilization treatment is crushed into medicinal material fine powder with a fineness of 100-120 meshes, wherein the yield of the medicinal material fine powder is not less than 95.0%.

[0072] The fine powder of the finely pulverized medicinal materials is made into capsules, and the specific steps include:

[0073] Step 150, first batch mixing (batch mixing).

[0074] The finely pulverized medicinal material powder was mixed for the first time, and the mixing time was 30 minutes.

[0075] Step 160: granulation and drying.

[0076] The granules were granulated with 5-7% starch slurry as a binder using a 14-mesh screen, and then dried at a constant temperature of 60° C. to control the moisture content of the granules to be ≤2.5%.

[0077] Step 170: crushing the dried particles.

[0078] The dried particles were crushed into fine particles with a crushing mesh size of 20 mesh.

[0079] Step 180, batch mixing again.

[0080] 0.5% magnesium stearate was added to the above fine granules and the mixture was batch mixed again for 30 minutes.

[0081] Step 190, capsule filling.

[0082] A fully automatic capsule filling machine is used for capsule filling, with a filling specification of 0.4g / capsule.

[0083] Step 200: aluminum-plastic packaging.

[0084] The product is packaged in a plastic-aluminum package using medicinal aluminum-plastic materials, with a packaging specification of 12 tablets per plate.

[0085] From the above preparation process, it can be seen that the preparation process of the present invention is simple, and does not require complex processes such as extraction, distillation, and paste clearing, thereby improving production efficiency and reducing production costs.

[0086] The clinical trial statistics of the Chinese medicine composition for treating ischemic stroke provided by the present invention are as follows:

[0087] 1. Cases and methods

[0088] Ten patients with ischemic stroke were included. All patients presented with neurological impairment affecting movement, balance, language, or vision, as diagnosed by imaging, and these symptoms were assessed at enrollment (see Table 1).

[0089] The Chinese medicine composition (capsule) for treating ischemic stroke provided by the present invention is taken between one week and six months after the stroke, 1.6 g each time, three times a day, for a course of 2 to 3 months. In addition to this product, the patient also takes antiplatelet, anticoagulant (warfarin), lipid-lowering, blood sugar-lowering, and blood pressure-lowering drugs.

[0090] 2. Summary of efficacy.

[0091] Clinical trial results showed that patients tolerated the treatment well, with only one case experiencing a mild adverse reaction, diarrhea, which resolved after the dosage was reduced and gradually increased to the normal dose within a week.

[0092] During follow-up, all patients reported improvement in their condition during treatment with this drug. Six patients recovered completely, three had good or moderate recovery, and one had poor recovery. Significant improvements were seen in motor, visual, language, and cognitive functions (Table 1).

[0093] Motor function: Eight patients with movement disorders experienced improvements in upper and lower limb strength and walking ability; six patients experienced complete recovery from their movement disorders.

[0094] Balance ability: The balance ability of 3 patients recovered.

[0095] Visual acuity: Diplopia and hemi-diplopia disappeared in 5 patients.

[0096] Speech: Speech disorders improved in four patients, including motor aphasia and anomia; after three months, speech disorders in two patients were completely recovered.

[0097] Notably, three patients began treatment with Danbenpin in the late stages of stroke recovery. Patient 8, six months into the post-stroke recovery phase, continued to see improvements in language and cognitive abilities. Two other patients (patients 6 and 7) began taking Danbenpin one month after their stroke and both showed significant improvement.

[0098] Table 1.

[0099]

[0100]

[0101] Based on the description of the above specific embodiments, the Chinese medicine composition for treating ischemic stroke and the preparation method thereof provided by the present invention have the following advantages compared with the prior art:

[0102] First, insect medicines and herbal medicines work synergistically.

[0103] Scalded leeches + earthworms + scorpions: Insect medicines are good at moving around, and have strong blood-breaking and collateral-opening abilities. When used with herbal blood-activating medicines (such as Salvia miltiorrhiza and Ligusticum chuanxiong), they form the effect of "herbal medicines for removing blood stasis, and insect medicines for dredging collaterals". They are especially suitable for the sequelae of ischemic stroke caused by long-term illness entering the collaterals.

[0104] Second, attack and supplement at the same time to eliminate evil without harming the body.

[0105] Astragalus replenishes Qi and strengthens the body, while Angelica nourishes and harmonizes blood. When used together with a large amount of blood-activating and blood-breaking drugs (such as peach kernel, safflower, and leech), it can avoid excessive consumption of Qi and blood. It is suitable for stroke patients with a constitution of deficiency in the original body and excess in the superficial aspects.

[0106] Third, take into account the multiple pathological factors of "stasis, wind, and phlegm".

[0107] It not only targets blood stasis (Danshen, Chuanxiong, and Carthamus tinctorius), but also takes into account wind movement (Gastrodia elata, Scorpion) and phlegm obstruction (Polygala tenuifolia, Acorus gramineus), which is in line with the complex pathogenesis of stroke of "blood stasis and phlegm intertwined, and wind and phlegm disturbing the upper body".

[0108] Fourth, guiding the meridians and targeting effects.

[0109] Chuanxiong leads the medicine upward to the head and enhances blood supply to the brain; Acorus calamus has a fragrant aroma that opens the orifices and directly targets blocked orifices in the brain, embodying the wisdom of "leading the medicine to the site of disease".

[0110] Fifth, the preparation process is simple, the production efficiency is high, and the production cost is low.

[0111] Finally, it should be noted that the terms "comprise," "include," or any other variations thereof, as used herein, are intended to encompass non-exclusive inclusion, such that a process, method, article, or apparatus comprising a list of elements includes not only those elements but also other elements not explicitly listed, or elements inherent to such process, method, article, or apparatus. In the absence of further limitations, an element defined by the phrase "comprising a..." does not preclude the presence of additional identical elements in the process, method, article, or apparatus comprising the element.

[0112] The present invention is not limited to the above-mentioned optimal implementation mode. Anyone should be aware that any structural changes made under the inspiration of the present invention, and any technical solutions that are the same or similar to the present invention, fall within the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating ischemic stroke, characterized in that: Made from the following raw materials in parts by weight: 7-10 parts of Salvia miltiorrhiza, 10-15 parts of Astragalus, 2-4 parts of Chuanxiong, 1-4 parts of scalded leech, 1-4 parts of Eupolyphaga sinensis, 1-4 parts of Gastrodia elata, 2-5 parts of Scorpio, 2-5 parts of Polygala tenuifolia, 2-5 parts of Acorus calamus, 7-10 parts of Red Peony Root, 2-5 parts of Carthamus tinctorius, 2-5 parts of Angelica sinensis, and 2-5 parts of Peach Kernel.

2. The Chinese medicine composition according to claim 1, characterized in that Made from the following raw materials in parts by weight: 8-9 parts of Salvia miltiorrhiza, 10-12 parts of Astragalus, 2-4 parts of Chuanxiong, 1-3 parts of scalded leech, 1-3 parts of Eupolyphaga sinensis, 1-3 parts of Gastrodia elata, 2-4 parts of Scorpio, 2-4 parts of Polygala tenuifolia, 2-4 parts of Acorus calamus, 8-9 parts of Red Peony Root, 2-4 parts of Carthamus tinctorius, 2-4 parts of Angelica sinensis, and 2-4 parts of Peach Kernel.

3. The Chinese medicine composition according to claim 1, characterized in that Made from the following raw materials in parts by weight: 8 parts of Salvia miltiorrhiza, 10 parts of Astragalus, 4 parts of Chuanxiong, 2 parts of Hirudo scaldii, 2 parts of Eupolyphaga sinensis, 2 parts of Gastrodia elata, 4 parts of Scorpio, 4 parts of Polygala tenuifolia, 4 parts of Acorus calamus, 8 parts of Paeonia lactiflora, 4 parts of Carthamus tinctorius, 4 parts of Angelica sinensis, and 4 parts of Peach Kernel.

4. A method for preparing the Chinese medicine composition according to claim 1, characterized in that: The following steps are involved: Prepare the raw materials of the corresponding components by weighing according to the formula of claim 1, mix and grind into a coarse medicinal powder of 40 to 60 mesh; The crude powder of medicinal materials is sterilized by moist heat; Grinding the coarse medicinal material powder after moist heat sterilization into medicinal material fine powder with a fineness of 100 to 120 mesh, wherein the yield of the medicinal material fine powder is not less than 95.0%; The medicinal materials are finely powdered and made into capsules.

5. The method according to claim 4, characterized in that The conditions for moist heat sterilization of medicinal material coarse powder are: Sterilization temperature is 115-117°C, sterilization time is 30 minutes, drying time is 60-120 minutes, drying vacuum degree is 0.06-0.08Mpa, and drying temperature is 60°C.

6. The method according to claim 4, characterized in that The preparation method of the capsule is as follows: The medicinal material fine powder was first batch mixed for 30 minutes; Using 5-7% starch slurry as a binder, granulation is performed using a 14-mesh screen, followed by constant temperature drying to control the moisture content of the granules to ≤2.5%; The dried particles were crushed into fine particles with a crushing mesh size of 20 mesh; Add 0.5% magnesium stearate to the above fine granules and batch mix again for 30 minutes; Use a fully automatic capsule filling machine for capsule filling.

7. The method according to claim 6, characterized in that The filling specification of the capsule is 0.4g / capsule.

8. Use of the traditional Chinese medicine composition according to claim 1 in preparing a medicament for treating ischemic stroke.

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