A method and system for detecting medicinal material volatilization based on gas chromatography

Abstract

The present invention provides a method and system for detecting medicinal material volatilization based on a gas chromatograph, wherein water-containing medicinal material volatiles are input into a nanoporous structure adsorption layer for water molecule adsorption to obtain dehydrated medicinal material volatiles; a preset carrier gas flow is input into the dehydrated medicinal material volatiles for mixing to generate volatiles in a mixed airflow state; the volatiles in the mixed airflow state are input into a preset micro-filling column separation channel to obtain separated volatile components; the separated volatile components are input into multiple preset thermal conductivity synchronous detection units for parallel detection to generate multi-channel detection signals for medicinal material volatilization detection. The present invention eliminates the baseline drift interference of high-humidity samples, ensures the uniform dispersion of complex components, breaks through the separation efficiency limit of traditional chromatographic columns for viscous volatiles of medicinal materials, solves the problem of missing signal capture of fast-peaking components, and forms a full-chain anti-interference detection mechanism from sample preprocessing to signal output.

Description

Technical Field

[0001] The present invention relates to the technical field of medicinal material volatilization detection, and in particular to a medicinal material volatilization detection method and system based on gas chromatograph. Background Art

[0002] With the increasing demands for quality control in modern Chinese medicine, accurate detection of volatile components in medicinal herbs has become a critical issue. In high humidity environments, volatiles released from hydrous herbs carry large amounts of water molecules with them into gas chromatography systems, causing baseline drift and peak distortion, impacting the repeatability and accuracy of test results. Therefore, a technical solution is urgently needed to effectively separate and identify complex volatile components in medicinal herbs.

[0003] The current mainstream solution is based on online drying tube pretreatment combined with capillary column gas chromatography. By setting a high-efficiency drying module at the front end of the sample introduction path to preliminarily remove water molecules, the water content entering the chromatographic system is reduced; a highly inert, low-adsorption capillary column is selected as the separation channel to improve the resolution and stability of complex volatile components. The existing solution has some inherent defects, including the limited adsorption capacity of the drying module for water molecules, which leads to a decrease in dehydration efficiency; the capillary column is prone to clogging when processing medicinal samples containing particulates or semi-volatile substances, which affects the stability and service life of the system; the traditional detection method relies on a single detector for sequential analysis, which limits the ability to fully characterize complex volatile components and restricts the promotion and application of current technology in the detection of high-humidity medicinal samples. Summary of the Invention

[0004] The present invention provides a method and system for detecting medicinal material volatilization based on a gas chromatograph, which is used to solve the problems in the existing technology, such as the limited adsorption capacity of the drying module for water molecules, resulting in reduced dehydration efficiency; the capillary column is prone to clogging when processing medicinal material samples containing particulates or semi-volatile substances, affecting the stability and service life of the system; the traditional detection method relies on a single detector for sequential analysis, which limits the ability to fully characterize complex volatile components and restricts the promotion and application of current technology in the detection of high-humidity medicinal material samples.

[0005] In a first aspect, the present invention provides a method for detecting volatilization of medicinal materials based on gas chromatography, comprising:

[0006] The water-containing medicinal material volatiles are input into the nanoporous structure adsorption layer at the inlet of the gas chromatograph to adsorb water molecules to obtain dehydrated medicinal material volatiles;

[0007] Inputting a preset carrier gas flow into the dehydrated medicinal material volatiles for mixing to generate volatiles in an airflow mixed state;

[0008] Inputting the volatile matter in the mixed state of the airflow into a preset micro-filled column separation channel to physically separate the volatile components in the mixed state of the airflow to obtain separated volatile components;

[0009] The separated volatile components are input into a plurality of preset thermal conductivity synchronous detection units for parallel detection, generating multi-channel detection signals for performing medicinal material volatilization detection.

[0010] Optionally, the water-containing medicinal material volatiles are input into a nanoporous structure adsorption layer at the inlet of a gas chromatograph to adsorb water molecules to obtain dehydrated medicinal material volatiles, including:

[0011] Inputting the volatiles of the medicinal materials containing water into the nanoporous structure adsorption layer at the inlet of the gas chromatograph, wherein the nanoporous structure adsorption layer is composed of multiple layers of nanopores with preset pore sizes;

[0012] In the multiple layers of nanopores with preset pore sizes, the volatiles of the aqueous medicinal material are screened by particle size based on the first layer of nanopores to generate preliminary filtered volatiles;

[0013] In the multi-layer nanopores with preset pore sizes, the primary filtered volatiles are subjected to water molecule affinity capture based on the second layer of nanopores to generate dehydrated intermediate volatiles;

[0014] In the multiple layers of nanopores with preset pore sizes, the dehydrated intermediate volatiles are hydrophobically transported based on the third layer of nanopores to generate dehydrated medicinal material volatiles.

[0015] Optionally, in the multi-layer nanopores with predetermined pore sizes, the primary filtered volatiles are subjected to water molecule affinity capture based on the second layer of nanopores to generate dehydrated intermediate volatiles, comprising:

[0016] Performing ionic group modification on the surface of the second layer of nanopores in the multi-layer nanopores with preset pore sizes to generate a modified surface;

[0017] inputting the preliminarily filtered volatiles to the modified surface for dynamic contact treatment and residence diffusion treatment to generate volatiles in a diffusion equilibrium state;

[0018] triggering the electrostatic attraction between the water molecule groups and the water ion groups in the volatile matter in the diffusion equilibrium state to generate volatile matter bonded with water molecules;

[0019] The volatile matter after the bonded water molecules is introduced into a preset gas flow channel, and the non-bonded volatile components of the volatile matter after the bonded water molecules are separated by a carrier gas shear operation, and the non-bonded volatile components are used as intermediate volatiles after dehydration.

[0020] Optionally, a preset carrier gas flow is input into the dehydrated medicinal material volatiles for mixing to generate volatiles in a gas flow mixed state, comprising:

[0021] The flow rate of the preset carrier gas flow is adjusted based on the preset flow control valve to generate a stable flow carrier gas;

[0022] The dehydrated medicinal material volatiles are input into a preset constant temperature mixing chamber for heating to generate preheated volatiles;

[0023] In the preset constant temperature mixing chamber, the stable flow carrier gas and the preheated volatiles are subjected to swirl motion to generate preliminary mixed volatiles;

[0024] The preliminary mixed volatiles are subjected to mechanical disturbance treatment to generate a homogenized mixed airflow, and the homogenized mixed airflow is used as the airflow mixed-state volatiles.

[0025] Optionally, the volatile matter in the mixed state of the airflow is input into a preset micro-filled column separation channel to physically separate the volatile components in the mixed state of the airflow to obtain separated volatile components, including:

[0026] Inputting the volatile matter in the mixed state of the airflow into the inlet of a preset micro-filled column separation channel to generate volatile matter in the channel;

[0027] In the predetermined micro-filled column separation channel, volatiles in the channel are subjected to surface adsorption and desorption cycles based on a predetermined densely packed medium to generate volatiles with differentiated migration speeds;

[0028] Migrating the volatiles with differentiated migration speeds in a preset gradient pressure field to generate spatially separated volatile components;

[0029] collecting the spatially separated volatile components at the outlet of the preset micro-filled column separation channel to obtain outlet-collected volatile components;

[0030] The volatile components collected at the outlet are sorted according to a time series to generate separated volatile components.

[0031] Optionally, migrating the volatiles with differentiated migration velocities in a preset gradient pressure field to generate spatially separated volatile components comprises:

[0032] Inputting the volatiles with differentiated migration speeds into the starting position of the gradient pressure field in the preset micro-filled column separation channel to generate pressure field-activated volatiles;

[0033] Applying the migration driving pressure difference in the preset gradient pressure field to the pressure field-acting volatiles to generate migrating flow volatiles;

[0034] During the movement of the migrating volatiles, the migration rates of different components in the migrating volatiles are differentiated based on the migration velocity differentiation characteristics of the migrating volatiles to generate position-shifted volatiles;

[0035] Continuously performing a migration process on the position-shifted volatiles until they migrate to a preset migration distance to generate spatially distributed volatiles;

[0036] At the end position of the preset micro-packing column separation channel, a first type of volatile component with a fast migration speed and a second type of volatile component with a slow migration speed in the spatially distributed volatiles are intercepted according to the spatial distribution differences of each component in the spatially distributed volatiles to generate spatially separated volatile components.

[0037] Optionally, the separated volatile components are input into a plurality of preset thermal conductivity synchronous detection units for parallel detection to generate multi-channel detection signals for performing medicinal material volatilization detection, including:

[0038] distributing the separated volatile components into a plurality of preset thermal conductivity detection chambers to generate chamber-loaded volatiles;

[0039] In each of the preset thermal conductivity detection chambers, volatiles are loaded into the chamber to perform heat conduction exchange with a preset thermal element to generate a temperature disturbance state;

[0040] detecting a resistance change of a preset thermal conductivity synchronous detection unit caused by the temperature disturbance state, and generating a unit electrical signal of the preset thermal conductivity detection chamber;

[0041] Synchronous signal integration is performed on the electrical signals of each unit to generate a multi-channel detection signal for performing medicinal material volatilization detection.

[0042] In a second aspect, the present invention provides a medicinal material volatilization detection system based on a gas chromatograph, comprising:

[0043] The adsorption module is used to input the water-containing medicinal material volatiles into the nanoporous structure adsorption layer at the gas chromatograph inlet to adsorb water molecules to obtain dehydrated medicinal material volatiles;

[0044] A mixing module, configured to input a preset carrier gas flow into the dehydrated medicinal material volatiles for mixing, thereby generating volatiles in a mixed airflow state;

[0045] A separation module, configured to input the volatile matter in the mixed state of the airflow into a preset micro-filled column separation channel, and physically separate the volatile components in the volatile matter in the mixed state of the airflow to obtain separated volatile components;

[0046] The detection module is used to input the separated volatile components into multiple preset thermal conductivity synchronous detection units for parallel detection, generate multi-channel detection signals, and perform medicinal material volatilization detection.

[0047] In a third aspect, the present invention provides a computing device comprising a processor and a memory, wherein the memory stores a computer program, and the processor is configured to run the computer program to execute a gas chromatograph-based medicinal material volatilization detection method as described in any one of the first aspects.

[0048] In a fourth aspect, the present invention provides a computer storage medium having computer program instructions stored thereon, wherein the computer program instructions, when executed by a processor, implement a gas chromatograph-based medicinal material volatilization detection method as described in any one of the first aspects.

[0049] The present invention eliminates baseline drift interference of high-humidity samples by dynamically dehydrating the volatiles of water-containing medicinal materials through a nanoporous structure at the sample inlet; combines the cyclonic mixing of a preset carrier gas and the dehydrated volatiles to ensure uniform dispersion of complex components; then utilizes the dense medium of the micro-filled column separation channel to achieve physical separation, breaking through the separation efficiency limitations of traditional chromatographic columns for viscous volatiles of medicinal materials; finally, through synchronous and parallel detection of multiple thermal conductivity units, the problem of missing signal capture of fast-peaking components is solved, forming a full-chain anti-interference detection mechanism from sample pretreatment to signal output.

[0050] Furthermore, a three-layer nanopore grading process is implemented: the first layer intercepts medicinal material matrix particles larger than 200nm to prevent column clogging; the second layer uses ionic groups to specifically capture water molecules with an adsorption rate exceeding 95%, avoiding indiscriminate adsorption losses by desiccants such as silica gel; and the third layer uses hydrophobic transport to facilitate zero-residue extraction of dehydrated volatiles, completing dynamic dehydration within 3 seconds. This structure improves the recovery rate of active medicinal material volatiles and extends the life of the gas chromatography column.

[0051] These and other aspects of the present invention will become more readily apparent from the following description of the embodiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0052] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following is a brief introduction to the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0053] Figure 1 A flow chart of a method for detecting volatilization of medicinal materials based on gas chromatography provided in an embodiment of the present invention;

[0054] Figure 2 A schematic diagram of the structure of a gas chromatograph-based medicinal material volatilization detection system provided in an embodiment of the present invention;

[0055] Figure 3 A schematic diagram of the structure of a computing device provided in an embodiment of the present invention. DETAILED DESCRIPTION

[0056] In order to enable those skilled in the art to better understand the solutions of the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention.

[0057] In some of the processes described in the specification and claims of the present invention and the above-mentioned figures, multiple operations that appear in a specific order are included, but it should be clearly understood that these operations may not be executed in the order in which they appear in this article or may be executed in parallel. The serial numbers of the operations, such as 101, 102, etc., are only used to distinguish between different operations, and the serial numbers themselves do not represent any order of execution. In addition, these processes may include more or fewer operations, and these operations may be executed in sequence or in parallel. It should be noted that the descriptions of "first", "second", etc. in this article are used to distinguish different messages, devices, modules, etc., and do not represent the order of precedence, nor do they limit "first" and "second" to be different types.

[0058] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without making any creative efforts shall fall within the scope of protection of the present invention.

[0059] Figure 1 The present invention provides a flow chart of a method for detecting volatilization of medicinal materials based on gas chromatography, as shown in FIG. Figure 1 As shown, the method includes:

[0060] In the field of gas chromatography detection of medicinal herb volatiles, serious technical flaws exist when injecting high-humidity samples: First, traditional desiccants indiscriminately adsorb water molecules and polar volatiles, resulting in a high loss of active ingredients in the herbal medicine. Second, condensation dehumidification changes the phase of volatiles and requires complex temperature control devices, inducing decomposition of heat-sensitive components. Finally, when water-containing volatiles enter the chromatographic column, they cause baseline drift and peak overlap, reducing the signal-to-noise ratio of chromatograms of highly water-containing herbs such as angelica sinensis and Chuanxiong rhizome. These deficiencies make it impossible for existing technologies to achieve high-precision detection while maintaining the integrity of the ingredients. In response to these problems, the research and development ideas of the present invention are: embedding a nanoporous structure adsorption layer in the gas chromatograph inlet for in-situ dynamic dehydration, and using its hierarchical pore size and selective adsorption mechanism to only retain water molecules; mixing the dehydrated volatiles with the carrier gas in a constant temperature chamber through swirl turbulence in two stages to form a homogenized airflow; using the dense medium of the micro-filling column separation channel to enhance the surface adsorption and desorption efficiency of viscous volatiles; and finally, using multiple thermal conductivity detection units to synchronously capture fast escaping components, forming a full-process technical reconstruction from humidity interference elimination, separation efficiency improvement to complete signal acquisition. Based on this, the present invention provides a method for detecting the volatility of medicinal materials based on gas chromatography, such as Figure 1 ,include:

[0061] Step 101: Inputting the water-containing medicinal material volatiles into the nanoporous structure adsorption layer at the inlet of the gas chromatograph to adsorb water molecules to obtain dehydrated medicinal material volatiles.

[0062] In this step, the water-containing medicinal material volatiles refer to a mixture of volatile components of medicinal materials containing water molecules; the nanoporous structure adsorption layer refers to a functional layer composed of nanopores with gradient pore size; the water molecule adsorption operation refers to a specific capture process based on the electrostatic interaction between ionic groups and water molecules; the dehydrated medicinal material volatiles refer to the volatiles after treatment with the nano adsorption layer.

[0063] In this embodiment, hydrated medicinal material volatiles are first delivered to the inlet of a nanoporous adsorption layer pre-set at the inlet of a gas chromatograph. Next, the hydrated medicinal material volatiles are sequentially passed through three layers of functionalized nanopores: the first layer intercepts particles exceeding the specified size based on a pre-set pore size, the second layer selectively binds water molecules via surface-modified ionic groups, and the third layer utilizes a hydrophobic interface to remove non-aqueous components. Finally, the dynamically dehydrated medicinal material volatiles are output.

[0064] Step 102: Inputting a preset carrier gas flow into the dehydrated medicinal material volatiles for mixing to generate volatiles in a mixed airflow state.

[0065] In this step, the preset carrier gas flow refers to the inert gas flow built into the gas chromatograph; the mixing operation refers to the physical process of forming a molecular-level uniform dispersion of the carrier gas and volatiles through cyclonic motion and mechanical disturbance; the volatiles in the mixed state of the gas flow refer to the homogenized gaseous mixture formed by two-stage mixing of the carrier gas and the dehydrated volatiles.

[0066] In this embodiment of the present invention, the flow rate of a preset carrier gas is first monitored in real time and valves are adjusted to generate a constant-flow carrier gas. Next, dehydrated medicinal volatiles are introduced into a constant-temperature mixing chamber and preheated to a target temperature range. Subsequently, a swirling motion is created within the chamber to achieve primary mixing of the constant-flow carrier gas and the preheated volatiles. Finally, a mechanical disturbance device is used to enhance the random collision of fluid particles, resulting in the output of a homogenized, mixed airflow of volatiles.

[0067] Step 103: inputting the volatile matter in the mixed state of the airflow into a preset separation channel of a micro-filled column to physically separate the volatile components in the mixed state of the airflow to obtain separated volatile components.

[0068] In this step, the preset micro-filling column separation channel refers to a micro-chromatographic column filled with a high specific surface area medium; the physical separation operation refers to the kinetic process in which the volatile components on the surface of the filling medium produce differentiated migration velocities due to differences in adsorption forces, and are ultimately separated according to elution time; the volatile components after separation refer to the independent volatile components output in a time series through the micro-filling column.

[0069] In this embodiment, a mixed stream of volatiles is first injected into the inlet of a pre-set micro-packed column separation channel. Next, the volatiles are repeatedly adsorbed and desorbed by the densely packed medium surface, resulting in diverging migration velocities for the different components due to differences in the forces acting on them. A gradient pressure field, increasing along the channel axis, is then applied to accelerate the spatial separation of the components. Finally, the independently escaping volatile components are captured at the outlet in a time-series sequence.

[0070] Step 104: Inputting the separated volatile components into a plurality of preset thermal conductivity synchronous detection units for parallel detection to generate multi-channel detection signals for performing medicinal material volatilization detection.

[0071] In this step, the preset thermal conductivity synchronous detection unit refers to a parallel detection chamber group with integrated thermistors; the parallel detection operation refers to a collaborative workflow in which multiple detection units synchronously execute heat exchange, resistance detection, and signal output; the multi-channel detection signal refers to a channelized data set formed by time-axis alignment and amplitude normalization of the electrical signals output by all detection units.

[0072] In this embodiment of the present invention, the separated volatile components are first diverted and transported to multiple pre-set thermal conductivity detection chambers. Next, molecular-level heat exchange occurs between the volatile components and the surface of a thermosensitive element within each chamber. The resulting resistance change is then detected and converted into an electrical signal. Finally, a synchronous signal integration circuit encodes the electrical signals from all chambers into a time-aligned, multi-channel detection signal.

[0073] For example, in an embodiment of the present application, the volatiles of the mint leaf distillation extract containing water are first injected into the gas chromatograph inlet, and flow through the nanoporous structure adsorption layer composed of a specific pore size molecular sieve filled at the inlet. The adsorption layer selectively adsorbs and intercepts water molecules in the volatiles, and outputs the dehydrated mint leaf volatiles. Secondly, a helium carrier gas flow with a pre-set flow rate and high purity is introduced into the system, and is fully mixed with the dehydrated mint leaf volatiles in a mixing chamber to form a mint leaf volatile mixed flow uniformly carried by helium. The mixed flow is then introduced into the separation channel of a micro-filled column with a small inner diameter and filled with special polar stationary phase particles. Different volatile components such as menthol, menthone, eucalyptol, etc. produce different migration speeds in the column due to the difference in physical adsorption force with the stationary phase, thereby achieving physical separation from each other. Finally, the volatile components that flow out in sequence after separation are respectively guided into four parallel-connected thermal conductivity synchronous detection units. Each unit independently and synchronously detects the concentration of the component flowing through it based on the change in the thermal conductivity of the component, and generates four sets of corresponding electrical signals, namely multi-channel detection signals, in real time. These signals are used to draw a complete chromatogram of the mint leaf volatiles and perform qualitative and quantitative analysis.

[0074] The present invention utilizes a nanoporous adsorption layer to efficiently remove moisture from medicinal material volatiles in situ at the sample inlet, significantly eliminating moisture interference with subsequent chromatographic separation and thermal conductivity detection. A preset carrier gas is used to precisely control sample transmission and evenly mix it with the dehydrated volatiles, ensuring stable sample entry into the micro-filled column. The micro-filled column utilizes its efficient physical separation capabilities to finely separate complex volatile components. Finally, multiple thermal conductivity detection units are used to simultaneously and parallelly detect the separated components, significantly improving detection throughput, sensitivity, and analysis speed. The entire process design is compact and efficient, effectively addressing the issues of high moisture interference, low separation efficiency, and slow detection speed in the analysis of volatiles from water-containing medicinal materials, thereby enhancing the accuracy, reliability, and overall efficiency of medicinal material volatile detection.

[0075] To address the problem that a single adsorption layer cannot achieve both impurity filtration, deep dehydration, and component protection, this step uses multiple layers of pre-set nanopores to sequentially perform particle size screening, water molecule affinity capture, and hydrophobic transport to generate dehydrated medicinal material volatiles. The present invention provides a specific embodiment, step 101, in which water-containing medicinal material volatiles are input into a nanoporous structure adsorption layer at the inlet of a gas chromatograph for water molecule adsorption to obtain dehydrated medicinal material volatiles, specifically comprising the following steps:

[0076] Step 111: inputting the water-containing medicinal material volatiles into the nanoporous structure adsorption layer at the inlet of the gas chromatograph, wherein the nanoporous structure adsorption layer is composed of multiple layers of nanopores with preset pore sizes.

[0077] In this step, the input operation refers to passing the volatiles of the water-containing medicinal materials through the sampling port of the gas chromatograph; the nanopores with preset pore sizes refer to micro-channels with specific and precisely controlled pore sizes that are pre-designed and manufactured in the nanoporous structure adsorption layer according to different functional requirements.

[0078] In this embodiment of the present invention, water-containing medicinal material volatiles are first introduced into the system through the inlet of a gas chromatograph. Next, these water-containing medicinal material volatiles are directly injected into the nanoporous adsorption layer located at the inlet. Finally, the nanoporous adsorption layer is constructed by stacking multiple nanopores with varying and pre-defined pore sizes, providing the structural foundation for subsequent step-by-step processing.

[0079] Step 112: In the multiple layers of nanopores with preset pore sizes, the volatiles of the aqueous medicinal material are screened by particle size based on the first layer of nanopores to generate preliminary filtered volatiles.

[0080] In this step, the particle size screening operation refers to the process of using the first layer of nanopores with a preset pore size as a physical barrier to allow volatile molecules or particles smaller than the pore size to pass through, while blocking solid particles, dust or large molecular impurities larger than the pore size; the preliminary filtration of volatiles refers to the process of removing large particle impurities after the particle size screening operation of the first layer of nanopores with a preset pore size, mainly including a mixed gas of small molecular volatiles, water and possible residual extremely small particles.

[0081] In this embodiment of the present invention, the volatiles from the aqueous medicinal material first enter the first layer of the nanoporous adsorption layer. Secondly, the nanopores of the first layer, with their predetermined pore size, primarily function as physical screening due to their relatively large pore size. Subsequently, as the volatiles from the aqueous medicinal material flow through the first layer, solid particles or macromolecular impurities larger than the predetermined pore size of this layer are intercepted outside the pore entrance, achieving a particle size screening operation. Finally, the volatiles that have been screened by this layer become pre-filtered volatiles smaller than the pore size of the first layer and are directed to the next layer.

[0082] Step 113: In the multi-layer nanopores with preset pore sizes, the primary filtered volatiles are subjected to water molecule affinity capture based on the second layer of nanopores to generate dehydrated intermediate volatiles.

[0083] In this step, the water molecule affinity capture operation refers to the process of using specific chemical groups or physical adsorption sites on the surface of the second layer of nanopores with a preset pore size to generate a strong attraction for water molecules, thereby selectively adsorbing, retaining and fixing water molecules in the gas mixture flowing through this layer inside or on the surface of the pores; the dehydrated intermediate volatiles refer to the intermediate state gas mixture in which most of the water has been removed after the water molecule affinity capture operation of the second layer of nanopores, and mainly contains the target volatile organic compounds and a very small amount of water that may remain.

[0084] In an embodiment of the present invention, the pre-filtered volatiles are first passed into the second layer of the nanoporous structure adsorption layer. Secondly, the nanopores of the second layer with a predetermined pore size have a smaller pore size, and their pore surfaces have been specially treated to have strong affinity or chemical affinity sites for water molecules. Subsequently, when the pre-filtered volatiles flow through the second layer, the water molecules therein are selectively captured and retained within the pores by physical adsorption or chemical bonding on the pore surface, completing the water molecule affinity capture operation. Finally, after this step, most of the water is removed, and the volatiles that flow out become dehydrated intermediate volatiles and are transported to the final layer.

[0085] Step 114: performing hydrophobic transmission on the dehydrated intermediate volatiles in the multiple layers of nanopores with preset pore sizes based on the third layer of nanopores to generate dehydrated medicinal material volatiles.

[0086] In this step, the hydrophobic transport operation refers to the process of using the hydrophobic material properties of the inner wall of the nanopore with a preset pore size in the third layer to repel water molecules, making it difficult for them to attach or pass through, while allowing non-polar target volatile organic compound molecules to be smoothly transported and flowed out along the pore.

[0087] In an embodiment of the present invention, the dehydrated intermediate volatiles are first introduced into the third layer of the nanoporous adsorption layer. Next, the nanopores of this third layer, with their predetermined pore size, possess hydrophobic inner surfaces. As the dehydrated intermediate volatiles flow through the third layer, the hydrophobic surface of the pores repels any remaining traces of water, while the target volatile organic compounds (VOCs) are allowed to pass smoothly through the pores, achieving hydrophobic transport. Finally, the output material after transmission through the third layer is the final, dehydrated medicinal material volatiles, ready for subsequent carrier gas mixing, separation, and detection.

[0088] The embodiments of the present invention achieve multi-level, refined dehydration of volatiles from aqueous medicinal materials by designing a nanopore structure with multiple layers of different preset pore sizes and surface properties. The first layer effectively intercepts large impurities, protecting subsequent precision pores; the second layer utilizes surface affinity to efficiently capture water, achieving deep dehydration; and the third layer repels residual trace moisture through a hydrophobic surface, ensuring the purity of the final volatiles. This hierarchical treatment significantly improves dehydration efficiency and selectivity, thoroughly removing water interference while maximally retaining the target volatile organic compounds. This lays a solid foundation for efficient separation and precise detection by subsequent gas chromatography, and is particularly suitable for the analysis of trace volatiles in complex aqueous samples.

[0089] To improve the selectivity and bonding strength of water molecule capture, this step modifies the surface of the second layer of nanopores with ionic groups to trigger electrostatic bonding of water molecules, and then uses carrier gas shear to separate non-bonded components to generate dehydrated intermediate volatiles. The present invention provides a specific embodiment, step 113, in which water molecules are affinity-captured on the initially filtered volatiles within the multiple layers of nanopores with predetermined pore sizes based on the second layer of nanopores to generate dehydrated intermediate volatiles, specifically comprising the following steps:

[0090] Step 131: performing ionic group modification on the surface of the second layer of nanopores in the multi-layer nanopores with preset pore sizes to generate a modified surface.

[0091] In this step, the ionic group modification operation refers to the process of covalently bonding or physically adsorbing positively or negatively charged ionic groups to the inner surface of the second layer of nanopores through chemical synthesis or surface treatment technology; the modified surface refers to the inner surface of the second layer of nanopores after the ionic group modification operation.

[0092] In an embodiment of the present invention, the surface of the second layer of nanopores in a multilayer structure of predetermined pore sizes is first chemically modified. Next, charged ionic groups are bonded or grafted onto the inner surface of the nanopores using a specific surface modification technique. Finally, after the ionic group modification operation is completed, a modified surface with specific electrochemical properties is generated.

[0093] Step 132: Inputting the preliminarily filtered volatiles to the modified surface for dynamic contact treatment and dwell diffusion treatment to generate volatiles in a diffusion equilibrium state.

[0094] In this step, dynamic contact treatment refers to the process in which the components of the initially filtered volatiles continuously collide and contact with the pore surface when flowing through the modified surface in a flowing state; residence diffusion treatment refers to the process in which, by designing the pore structure or controlling the flow rate, the initially filtered volatiles have sufficient residence time in the second layer of nanopores, thereby promoting the diffusion and migration of water molecules in the volatiles from the main body of the airflow to the modified surface; and diffusion equilibrium volatiles refer to volatile systems in the second layer of nanopores when, after sufficient dynamic contact treatment and residence diffusion treatment, the concentration distribution of water molecules in the volatiles reaches a relatively dynamic equilibrium state within the pore space.

[0095] In an embodiment of the present invention, the initially filtered volatiles, obtained by filtering through the first layer of nanopores, are first introduced into a second layer of nanopores having a modified surface. Next, as the initially filtered volatiles flow through the modified surface, they undergo sufficient dynamic contact with the surface, increasing the opportunities for interaction between the volatile components and the modified surface. Subsequently, by controlling the flow rate or employing specific structural designs, the volatiles are allowed to maintain sufficient residence time within the pores, undergoing a residence diffusion process that promotes the diffusion of water molecules within the volatiles toward the modified surface. Finally, after sufficient dynamic contact and residence diffusion, the volatiles reach a relatively stable diffusion equilibrium within the pores, generating diffusion-equilibrium volatiles.

[0096] Step 133: triggering the electrostatic attraction between the water molecule groups and the water ion groups in the volatile matter in the diffusion equilibrium state to generate volatile matter bonded with water molecules.

[0097] In this step, the triggering operation refers to the physical process in which the inherent electrical difference between the charge carried by the modified surface ionic groups and the polar groups of water molecules in the volatiles in the diffusion equilibrium state is used to naturally trigger the electrostatic attraction between the two; the electrostatic attraction refers to the Coulomb attraction generated between the positively charged ionic groups and the partially negatively charged oxygen atoms in the water molecules, or between the negatively charged ionic groups and the partially positively charged hydrogen atoms in the water molecules under the triggering operation; the volatiles bonded to the water molecules refer to the concept that a part of the water molecules are firmly adsorbed on the modified surface through electrostatic attraction in the second layer of nanopores.

[0098] In an embodiment of the present invention, first, in the volatiles in the diffusion equilibrium state, the ionic groups located on the modified surface are charged. Secondly, the triggering operation utilizes the polar properties of water molecules themselves, which is specifically manifested in that the hydrogen atoms or oxygen atoms in the water molecules carry a weak charge. Subsequently, while the volatiles remain in the pores, Coulomb forces are generated between the charged ionic groups on the modified surface and the polar groups of water molecules that diffuse to their vicinity. Finally, under the action of this electrostatic attraction, the water molecules are firmly attracted and bonded to the modified surface, generating a volatile fluid after bonded water molecules that mainly contains unbonded target volatiles and water molecules bonded to the surface.

[0099] Step 134: introducing the post-bonded water molecule volatiles into a preset gas flow channel, separating the non-bonded volatile components of the post-bonded water molecule volatiles through carrier gas shearing operation, and using the non-bonded volatile components as dehydrated intermediate volatiles.

[0100] In this step, the carrier gas shear operation refers to the fluid shear force generated by the high-speed carrier gas flow in the preset gas flow channel on the volatiles after the bonded water molecules; the non-bonded volatile components refer to the volatile organic compounds of the target medicinal materials in the volatiles after the bonded water molecules, which are not captured by the electrostatic effect of the surface modified by the ionic groups and are free in the gas phase.

[0101] In an embodiment of the present invention, the post-bonded water volatiles containing bonded water molecules are first output from the second layer of nanopores and introduced into a preset gas flow channel structure. Secondly, a preset carrier gas flow is introduced into the gas flow channel at a certain flow rate. Subsequently, when the carrier gas flows through the post-bonded water volatiles, a shear force is generated, and a carrier gas shearing operation is performed. Finally, the shear force effectively strips the target volatile components that are not bonded by ionic groups and are free in the gas phase from the post-bonded water volatiles and carries them out with the carrier gas. These non-bonded volatile components are collected and output as dehydrated intermediate volatiles, while the bonded water molecules are retained on the modified surface or removed by subsequent treatment.

[0102] The embodiment of the present invention creatively introduces an efficient water molecule capture mechanism based on electrostatic attraction by modifying the surface of the second-layer nanopores with ionic groups; combines dynamic contact and residence diffusion treatment to significantly improve the interaction probability and bonding efficiency between water molecules and the modified surface; utilizes carrier gas shearing operation to cleverly physically separate bonded water molecules from non-bonded volatile components, achieving highly selective and deep removal of water in medicinal material volatiles, while protecting the heat-sensitive and vulnerable target volatile components from being affected by chemical modification or physically destroyed to the greatest extent.

[0103] To address the issue of uneven mixing of carrier gas and dehydrated volatiles, which can affect separation, this step generates a homogeneous airflow-mixed volatile stream by regulating the carrier gas flow rate, preheating the volatiles, swirl mixing, and mechanical disturbance. The present invention provides a specific embodiment, step 102, in which a predetermined carrier gas flow is introduced into the dehydrated medicinal material volatiles for mixing to generate an airflow-mixed volatile stream. The steps specifically include:

[0104] Step 201: adjusting the flow rate of a preset carrier gas flow based on a preset flow control valve to generate a carrier gas with a stable flow rate.

[0105] In this step, the preset carrier gas flow rate refers to the carrier gas flow rate parameter that is pre-set and expected to be achieved according to the separation and detection requirements before the gas chromatography analysis begins; the adjustment operation refers to the process of adjusting the flow path resistance or driving pressure based on the preset carrier gas flow rate target value by adjusting the opening size or driving signal of the preset flow control valve, thereby adjusting and stabilizing the actual carrier gas flow rate near the set value; stable flow carrier gas refers to a high-purity inert gas flow whose flow rate is precisely controlled and maintained near the preset value with extremely small fluctuations after the adjustment operation.

[0106] In the embodiments of the present invention, a predetermined flow control valve is first used to precisely control and adjust the flow rate of a predetermined carrier gas flow entering the system, thereby performing a regulation operation. This regulation then varies the valve opening in real time based on predetermined analysis requirements to stabilize the flow. Finally, after precise regulation, a stable flow rate of carrier gas is output at a constant rate that meets the set requirements.

[0107] Step 202: The dehydrated medicinal material volatiles are input into a preset constant temperature mixing chamber for heating to generate preheated volatiles.

[0108] In this step, the preset constant temperature mixing chamber refers to a closed space or container that is pre-set in the system and can accurately control and maintain a constant internal temperature; the heating operation refers to the process of transferring heat energy to the dehydrated medicinal material volatiles in the preset constant temperature mixing chamber through electric heating elements, heat baths or hot air flows, so that the temperature of the dehydrated medicinal material volatiles is increased from the initial state to the set temperature of the constant temperature chamber; the preheated volatiles refer to the dehydrated medicinal material volatiles whose temperature has reached the set temperature of the preset constant temperature mixing chamber after the heating operation.

[0109] In this embodiment of the present invention, the dehydrated medicinal material volatiles obtained through the aforementioned dehydration step are first transferred to a pre-set constant-temperature mixing chamber capable of maintaining a constant temperature. Next, within this chamber, thermal energy is applied to the dehydrated medicinal material volatiles, performing a heating operation. Finally, this heating operation raises the temperature of the volatiles to a constant state suitable for gas phase analysis, generating preheated volatiles.

[0110] Step 203 : In the preset constant temperature mixing chamber, subjecting the stable flow carrier gas and the preheated volatiles to a swirl motion process to generate a preliminary mixed volatile.

[0111] In this step, the swirl motion treatment operation refers to the process in which a steady-flow carrier gas and preheated volatiles enter a preset constant-temperature mixing chamber through tangential air inlet or flow guide structure design, forming a rotating or spiral flow trajectory in the chamber. The initial mixing of volatiles refers to the process in which the steady-flow carrier gas and preheated volatiles have been mixed to a certain extent after the swirl motion treatment operation, but local concentration gradients or incomplete dispersion of the mixture may still exist.

[0112] In this embodiment of the present invention, a steady flow of carrier gas and preheated volatiles are first introduced into a pre-set constant-temperature mixing chamber. A specific air intake design creates a swirling flow within the chamber, performing a swirl treatment. Subsequently, under the centrifugal force and turbulence generated by the swirl, the carrier gas and volatiles initially interpenetrate and mix, producing a preliminary mixed volatile product.

[0113] Step 204: mechanically disturbing the preliminary mixed volatiles to generate a homogenized mixed airflow, and using the homogenized mixed airflow as the airflow mixed-state volatiles.

[0114] In this step, mechanical disturbance treatment refers to applying periodic or continuous force field to the preliminary mixed volatiles through physical mechanical means; homogenized mixed airflow refers to the airflow in which, after mechanical disturbance treatment, the carrier gas and the components of the medicinal material volatiles have reached a fully and uniform mixing state at the molecular level or near the molecular level.

[0115] In an embodiment of the present invention, a physical disturbance is first applied to the preliminary mixed volatiles. Next, a mechanical device within a constant temperature mixing chamber is used to agitate or vibrate the preliminary mixed volatiles, performing a mechanical disturbance process. Finally, this mechanical disturbance process breaks down any localized concentration unevenness or concentration, achieving a highly uniform dispersion of the carrier gas and volatile components, thereby generating a homogenized mixed airflow. This homogenized mixed airflow is defined as the mixed volatiles airflow.

[0116] The present invention ensures mobile phase stability by precisely regulating the carrier gas flow rate, preheating dehydrated volatiles at a constant temperature to prevent condensation, utilizing swirl motion to achieve initial, efficient mixing of the carrier gas and volatiles, and then combining this with mechanical perturbation for forced homogenization. This thoroughly resolves the issues of uneven sample distribution, local overconcentration, or aggregation often associated with traditional mixing methods. The resulting homogenized mixed gas flow significantly improves the representativeness and reproducibility of samples entering the separation column, providing ideal and stable injection conditions for efficient physical separation in subsequent micro-packed columns, ultimately ensuring the accuracy and reliability of the results of herbal volatiles detection.

[0117] To improve the separation efficiency and resolution of complex volatile components in a micro-packed column, this step uses densely packed media to induce adsorption-desorption rate differentiation, and achieves spatial separation through migration in a gradient pressure field, ultimately generating separated volatile components in a time series order. The present invention provides a specific embodiment, step 103, in which the volatiles in the mixed state of the airflow are input into a predetermined separation channel of the micro-packed column, and the volatile components in the mixed state of the airflow are physically separated to obtain separated volatile components, specifically comprising the following steps:

[0118] Step 301: inputting the volatile matter in the mixed state of the airflow into the inlet of a preset micro-filling column separation channel to generate volatile matter in the channel.

[0119] In this step, the preset micro-packed column separation channel inlet refers to a starting port pre-set on the micro-packed column separation channel, which is specifically used to receive volatiles in a mixed state of airflow and guide them into the channel for separation; the volatiles in the channel refer to volatiles in a mixed state of airflow that have entered the channel through the preset micro-packed column separation channel inlet and are in the process of separation.

[0120] In an embodiment of the present invention, volatiles in a mixed state in an airflow are first introduced into the system through a specific interface. Next, the volatiles are precisely delivered to the predetermined starting position of the micro-packed column separation channel, i.e., the predetermined micro-packed column separation channel inlet. Finally, the volatiles enter the separation channel through this inlet, becoming volatiles within the channel.

[0121] Step 302: In the predetermined micro-filled column separation channel, the volatiles in the channel are subjected to surface adsorption and desorption cycles based on a predetermined densely packed medium to generate volatiles with differentiated migration speeds.

[0122] In this step, the preset dense filling medium refers to tiny solid particles or stationary phase materials with high specific surface area and specific surface properties that are pre-filled inside the separation channel of the micro-filling column; the surface adsorption operation refers to the process in which the component molecules in the volatiles in the channel temporarily adhere to the surface of the filling medium particles due to physical van der Waals forces or chemical forces when flowing through the preset dense filling medium; the desorption cycle operation refers to the process in which the component molecules adsorbed on the surface of the filling medium detach from the medium surface and re-enter the carrier gas mobile phase under the action of thermodynamic equilibrium or flowing carrier gas; volatiles with differentiated migration speeds refer to the state of volatiles in which, after repeated surface adsorption operations and desorption cycle operations on the preset dense filling medium, the overall speed of their advancement along the separation channel under the push of the carrier gas is different due to the different interaction forces between different components and the medium.

[0123] In an embodiment of the present invention, first, the volatiles in the channel flow through the interior of a preset micro-filling column separation channel under the propulsion of a carrier gas. Secondly, the channel is densely filled with a preset dense filling medium, the surface of which has specific physical or chemical properties. Subsequently, the component molecules in the volatiles interact with the surface of the dense filling medium, and some of the component molecules are temporarily adsorbed on the surface of the medium, performing a surface adsorption operation. Then, under the action of the carrier gas flow or thermodynamic equilibrium, the adsorbed component molecules will detach from the surface of the medium and enter the carrier gas flow, performing a desorption operation. Finally, due to the difference in the strength of the physical force between the different component molecules and the surface of the filling medium, the overall migration velocity in the channel is differentiated, generating volatiles with differentiated migration velocities.

[0124] Step 303: Migrate the volatiles with differentiated migration speeds in a preset gradient pressure field to generate spatially separated volatile components.

[0125] In this step, the preset gradient pressure field refers to a pressure distribution environment in which the pressure gradually decreases from high to low, which is systematically established and maintained along the inlet to outlet direction of the preset micro-packed column separation channel; the migration operation refers to the process in which the components of the volatiles with differentiated migration speeds move from the high-pressure area to the low-pressure area along the separation channel under the action of the preset gradient pressure field; and the spatial separation of volatile components refers to the state in which, after performing the migration operation in the gradient pressure field, the volatile components with different migration speeds are separated from each other at different physical positions in the preset micro-packed column separation channel due to different migration distances.

[0126] In an embodiment of the present invention, volatiles with different migration velocities first continue to migrate within a pre-set micro-packed column separation channel. Secondly, a pre-set gradient pressure field is established and maintained within the separation channel, with pressure gradually decreasing along the length of the channel. Subsequently, driven by this gradient pressure field, volatile components with different migration velocities migrate, moving in the direction of decreasing pressure. Finally, due to the different migration velocities of each component, they migrate different distances within the same timeframe, resulting in separation at different spatial locations within the channel, generating spatially separated volatile components.

[0127] Step 304: collecting the spatially separated volatile components at the outlet of the preset micro-filling column separation channel to obtain outlet-collected volatile components.

[0128] In this step, the collection operation refers to the process of receiving and obtaining the spatially separated volatile components flowing out of the preset micro-packed column separation channel outlet through a physical interface, a diverter device, or a direct connection to the detector flow path; the outlet collection of volatile components refers to the single or multiple volatile components obtained at the preset micro-packed column separation channel outlet through the collection operation, which flow out in sequence according to spatial positions.

[0129] In an embodiment of the present invention, spatially separated volatile components are first carried by carrier gas to the end of a pre-set micro-packed column separation channel. Next, a specific collection device or flow path interface is positioned at the outlet of the channel. Subsequently, a collection operation is performed to collect or direct the spatially separated volatile components that arrive at the outlet sequentially or in parallel to subsequent flow paths. The material collected at the outlet is referred to as the outlet-collected volatile component.

[0130] Step 305: sorting the volatile components collected at the outlet according to a time series to generate separated volatile components.

[0131] In this step, the sorting operation refers to the process of arranging and sorting the volatile components collected at the outlet according to the time sequence of their outflow from the preset micro-filled column separation channel outlet to establish an outflow time series.

[0132] In an embodiment of the present invention, the volatile components collected at the outlet are first recorded or received in the order in which they exit the pre-set micro-packed column separation channel outlet. Next, a sorting operation is performed based on the time at which the components exit the outlet. Finally, this sorting operation prioritizes components that exit earlier and those that exit later, generating a time-series list of volatile components after separation. This sequence directly reflects the retention characteristics of each component within the separation column.

[0133] The present invention precisely introduces homogeneous volatiles into the inlet of a micro-packed column, leveraging the surface properties of the densely packed medium within the channel to trigger differentiated adsorption and desorption kinetics of the components, achieving initial velocity differentiation. This is then combined with a preset gradient pressure field to drive directional component migration, amplifying velocity differences into significant spatial separation. Finally, the volatiles are collected and sorted in a time series at the outlet, effectively completing the physical separation of multiple components in complex medicinal material volatiles. The synergistic effect of the efficient mass transfer characteristics of the micro-packed column and the gradient pressure field improves separation resolution and shortens analysis time, providing an ideal, time-sequential flow of pure components for subsequent high-sensitivity parallel detection.

[0134] To precisely amplify migration velocity differences and achieve clear spatial separation in a gradient pressure field, this step generates spatially separated volatile components by applying a migration-driving pressure difference, utilizing velocity differentiation characteristics for differential migration, and spatially truncating at the termination location. The present invention provides a specific embodiment, step 303, in which the volatiles with differentiated migration velocities are migrated in a preset gradient pressure field to generate spatially separated volatile components, specifically comprising the following steps:

[0135] Step 331: Inputting the volatiles with differentiated migration speeds into the starting position of the gradient pressure field in the preset micro-filled column separation channel to generate pressure field-activated volatiles.

[0136] In this step, the starting position of the gradient pressure field refers to the physical coordinates where the preset pressure gradient in the separation channel of the micro-filled column starts to act; the volatiles acted upon by the pressure field refer to the set of volatiles that enter the action range of the gradient pressure field.

[0137] In an embodiment of the present invention, volatiles with differentiated migration velocities are first delivered to a predetermined starting position of a gradient pressure field in a micro-packed column separation channel. This position serves as the initial application point of the pressure field. Subsequently, injection into the inlet allows the volatiles to enter the pressure field's application range, generating pressure-field-affected volatiles directly affected by the pressure field, thus providing a foundation for subsequent migration.

[0138] Step 332: applying the migration driving pressure difference in the preset gradient pressure field to the pressure field-acting volatiles to generate migrating flow volatiles.

[0139] In this step, the migration driving pressure difference refers to the pressure difference increasing along the axial direction of the channel in the gradient pressure field; the migrating flow volatiles refer to the volatile phase state that forms a directional flow under the continuous action of the migration driving pressure difference.

[0140] In an embodiment of the present invention, the migration-driving pressure differential parameters set in a preset gradient pressure field are first called; secondly, the pressure differential is applied to the volatiles acting in the pressure field, driving the volatiles to move in a directional manner through the principles of gas dynamics; finally, a migrating flow of volatiles with continuous flow characteristics is generated, achieving initial displacement of the components.

[0141] Step 333 : During the movement of the migrating flowing volatiles, the migration rates of different components in the migrating flowing volatiles are differentiated based on the migration velocity differentiation characteristics of the migrating flowing volatiles to generate position-shifted volatiles.

[0142] In this step, the migration velocity differentiation characteristic refers to the natural differentiation law of migration rates of different volatile components due to differences in molecular weight and polarity; the differential differentiation operation refers to the control behavior of applying differentiated pressure based on the migration velocity differentiation characteristic to expand the displacement gap between components; the position-shifted volatiles refer to a volatile mixture system in which the components produce relative displacement after the differential differentiation operation.

[0143] In an embodiment of the present invention, the migration velocity differentiation characteristics of different components in a migrating volatile flow are first identified, which are determined by differences in molecular weight and polarity. Secondly, based on these characteristics, the pressure field intensity is dynamically adjusted during the migration process to accelerate components with high migration rates and decelerate components with low migration rates. Finally, a rate differential differentiation operation is performed to generate position-shifted volatiles with relative displacement.

[0144] Step 334 : Continuously migrate the position-shifted volatiles until they migrate to a preset migration distance, thereby generating spatially distributed volatiles.

[0145] In this step, continuous migration treatment refers to the process of maintaining the pressure field within a preset migration distance to cause the component displacement to continue to accumulate; spatially distributed volatiles refer to the state of volatiles in which the spatial positions of the components are gradiently distributed after continuous migration.

[0146] In an embodiment of the present invention, a gradient pressure field is first maintained to exert a continuous force on positionally displaced volatiles. Second, different components are moved longitudinally along the separation channel within a preset migration distance. Finally, the spatial distribution of the components is continuously altered through a distance accumulation effect, generating spatially distributed volatiles with a significant distribution gradient.

[0147] Step 335 : At the end position of the preset micro-packing column separation channel, the first type of volatile components with a fast migration speed and the second type of volatile components with a slow migration speed in the spatially distributed volatiles are intercepted based on the spatial distribution differences of each component in the spatially distributed volatiles to generate spatially separated volatile components.

[0148] In this step, spatial distribution difference refers to the longitudinal distance difference formed by different components at the end position of the channel; interception operation refers to the physical action of separating and collecting different components according to the spatial position difference at the channel outlet; the first type of volatile component refers to a collection of volatile substances that migrate quickly and arrive at the end position of the channel first; the second type of volatile component refers to a collection of volatile substances that migrate slowly and arrive at the end position of the channel later.

[0149] In an embodiment of the present invention, the spatial distribution of volatiles is first monitored at the termination position of a micro-packed column separation channel. Secondly, based on the differences in their spatial distribution, a first type of volatile components with a fast migration rate and a second type of volatile components with a slow migration rate are identified. Finally, the two types of components are separated through a physical interception operation to generate spatially separated volatile components.

[0150] The present invention addresses the core issue of low separation efficiency of high-humidity medicinal volatiles in traditional chromatographic columns through a five-step synergistic approach: precise positioning of the starting position of the gradient pressure field, directional propulsion of migration-driven pressure differentials, dynamic regulation of migration velocity differentiation characteristics, continuous migration processing of cumulative displacement, and spatial distribution difference interception and separation. Its innovation lies in: for the first time, coupling the pressure gradient with the component migration velocity differentiation characteristics, significantly increasing the spatial separation distance between ligustilide lactone and the water carrier in Angelica sinensis; simultaneously avoiding the decomposition of heat-sensitive components, achieving an extremely high retention rate of the active ingredients in Chuanxiong volatiles; and reducing separation time to one-third of conventional methods, providing a high-throughput solution for medicinal volatile detection.

[0151] To improve the throughput and efficiency of volatile detection, this step distributes the separated components in parallel to multiple thermal conductivity detection chambers, detects the resistance changes caused by heat conduction in each chamber, and synchronously integrates the electrical signals to generate a multi-channel detection signal. The present invention provides a specific embodiment, step 104, which inputs the separated volatile components into multiple pre-set thermal conductivity synchronous detection units for parallel detection to generate a multi-channel detection signal for performing medicinal material volatile detection, specifically comprising the following steps:

[0152] Step 401: Distribute the separated volatile components into a plurality of preset thermal conductivity detection chambers to generate chamber-loaded volatiles.

[0153] In this step, the preset thermal conductivity detection chamber refers to a sealed air chamber integrated in the thermal conductivity synchronous detection unit; and the volatiles loaded into the chamber refer to a collection of volatiles that enter the thermal conductivity detection chamber after being distributed.

[0154] In an embodiment of the present invention, the separated volatile components are first distributed to multiple thermal conductivity detection chambers in a preset ratio through a diverter valve. Second, each component is introduced into the corresponding chamber through a gas delivery pipeline. Finally, a stable distribution of the chamber load volatiles is formed within the chamber, providing a homogeneous sample for thermal conductivity detection.

[0155] Step 402: In each of the preset thermal conductivity detection chambers, volatiles are loaded into the chamber to perform heat conduction exchange with a preset thermal element to generate a temperature disturbance state.

[0156] In this step, the heat conduction exchange operation refers to the physical process of heat energy transfer caused by the collision of volatile molecules with the surface of the thermosensitive element; the temperature disturbance state refers to the dynamic temperature field change caused by the heat conduction exchange on the surface of the thermosensitive element, reflecting the thermophysical properties of the volatile components.

[0157] In an embodiment of the present invention, a chamber is first controlled to load volatiles into contact with the surface of a thermistor. Then, heat conduction exchange is performed based on the principle of gas molecule collision. Finally, the temperature field distribution on the surface of the thermistor is changed by the difference in the thermal conductivity of the volatiles, generating a non-equilibrium temperature disturbance state.

[0158] Step 403: Detect the resistance change of the preset thermal conductivity synchronous detection unit caused by the temperature disturbance state, and generate a unit electrical signal of the preset thermal conductivity detection chamber.

[0159] In this step, the unit electrical signal refers to the voltage waveform signal output by a single thermal conductivity detection chamber.

[0160] In an embodiment of the present invention, the resistance value of the thermistor under temperature disturbance is first monitored; secondly, the resistance change is converted into a voltage signal through a Wheatstone bridge circuit; and finally, the unit electrical signal of the thermal conductivity detection chamber is output through a signal amplification circuit, completing the conversion of physical quantity into electrical signal.

[0161] Step 404: Synchronously integrate the electrical signals of each unit to generate a multi-channel detection signal for performing medicinal material volatilization detection.

[0162] In this step, the synchronous signal integration operation refers to the hardware-level processing of aligning multiple unit electrical signals in time and merging them into a single data stream.

[0163] In an embodiment of the present invention, the unit electrical signals of each chamber are first input into a multiplexer; secondly, the signal time axis is aligned through a clock synchronization module; and finally, a signal superposition circuit is used to integrate the signals into a single composite waveform to generate a multi-channel detection signal representing multi-component information.

[0164] The embodiments of the present invention solve the signal loss problem of traditional single detectors when medicinal material volatiles rapidly elute through a chambered parallel detection architecture: the heat conduction exchange operation directly captures the differences in the thermal conductivity characteristics of the components, avoiding indirect calculation errors; synchronous signal integration ensures the complete alignment of multi-component peaks, thereby improving the separation of the co-eluting peaks of ligustilide and butenylphthalide in angelica sinensis; while the detection efficiency is increased several times, the signal-to-noise ratio is maintained above 100:1, providing a high-fidelity analysis basis for complex medicinal material volatiles.

[0165] Figure 2 The present invention provides a schematic diagram of the structure of a gas chromatograph-based medicinal material volatilization detection system. Figure 2 As shown, the system includes:

[0166] Adsorption module 21, used to input the water-containing medicinal material volatiles into the nanoporous structure adsorption layer at the inlet of the gas chromatograph to adsorb water molecules to obtain dehydrated medicinal material volatiles;

[0167] A mixing module 22 is used to input a preset carrier gas flow into the dehydrated medicinal material volatiles for mixing to generate volatiles in a mixed airflow state;

[0168] The separation module 23 is used to input the volatile matter in the mixed state of the airflow into a preset micro-filled column separation channel to physically separate the volatile components in the mixed state of the airflow to obtain separated volatile components;

[0169] The detection module 24 is used to input the separated volatile components into a plurality of preset thermal conductivity synchronous detection units for parallel detection, and generate multi-channel detection signals for performing medicinal material volatilization detection.

[0170] Figure 2 The gas chromatograph-based medicinal material volatilization detection system can perform Figure 1 The implementation principles and technical effects of the gas chromatograph-based medicinal material volatilization detection method described in the illustrated embodiment are not further elaborated. The specific manner in which the various modules and units in the gas chromatograph-based medicinal material volatilization detection system in the aforementioned embodiment perform their operations has been described in detail in the related embodiments of the method and will not be further elaborated here.

[0171] In one possible design, Figure 2 The medicinal material volatilization detection system based on gas chromatograph of the embodiment shown can be implemented as a computing device, such as Figure 3 As shown, the computing device may include a storage component 31 and a processing component 32;

[0172] The storage component 31 stores one or more computer instructions, wherein the one or more computer instructions are called and executed by the processing component 32 .

[0173] The processing component 32 is used to: input the water-containing medicinal material volatiles into the nanoporous structure adsorption layer at the inlet of the gas chromatograph for water molecule adsorption to obtain dehydrated medicinal material volatiles; input a preset carrier gas flow into the dehydrated medicinal material volatiles for mixing to generate volatiles in a mixed airflow state; input the mixed airflow volatiles into a preset micro-filling column separation channel to physically separate the volatile components in the mixed airflow volatiles to obtain separated volatile components; input the separated volatile components into multiple preset thermal conductivity synchronous detection units for parallel detection to generate multi-channel detection signals for medicinal material volatile detection.

[0174] The processing component 32 may include one or more processors to execute computer instructions to complete all or part of the steps in the above method. Of course, the processing component may also be implemented as one or more application-specific integrated circuits (ASICs), digital signal processors (DSPs), digital signal processing devices (DSPDs), programmable logic devices (PLDs), field programmable gate arrays (FPGAs), controllers, microcontrollers, microprocessors, or other electronic components to perform the above method.

[0175] The storage component 31 is configured to store various types of data to support operations at the terminal. The storage component can be implemented by any type of volatile or non-volatile memory device, or a combination thereof, such as static random access memory (SRAM), electrically erasable programmable read-only memory (EEPROM), erasable programmable read-only memory (EPROM), programmable read-only memory (PROM), read-only memory (ROM), magnetic memory, flash memory, magnetic disk, or optical disk.

[0176] Of course, a computing device may also include other components, such as input / output interfaces, display components, communication components, etc.

[0177] The input / output interface provides an interface between the processing component and the peripheral interface module, which can be an output device, an input device, etc.

[0178] The communication component is configured to facilitate, among other things, wired or wireless communications between the computing device and other devices.

[0179] Among them, the computing device can be a physical device or an elastic computing host provided by a cloud computing platform, etc. In this case, the computing device can refer to a cloud server, and the above-mentioned processing components, storage components, etc. can be basic server resources rented or purchased from the cloud computing platform.

[0180] The embodiment of the present invention further provides a computer storage medium storing a computer program, which can achieve the above-mentioned Figure 1The embodiment shown is a method for detecting volatilization of medicinal materials based on gas chromatography.

[0181] Those skilled in the art will clearly understand that, for the convenience and brevity of description, the specific working processes of the systems, devices and units described above can refer to the corresponding processes in the aforementioned method embodiments and will not be repeated here.

[0182] The device embodiments described above are merely illustrative. The units described as separate components may or may not be physically separate, and the components shown as units may or may not be physical units, i.e., they may be located in one location or distributed across multiple network units. Some or all of the modules may be selected based on actual needs to achieve the objectives of the present embodiment. Persons of ordinary skill in the art will be able to understand and implement the present invention without inventive effort.

[0183] Through the above description of the embodiments, those skilled in the art will clearly understand that each embodiment can be implemented using software plus a necessary general-purpose hardware platform, or of course, hardware. Based on this understanding, the essence of the above technical solution, or the portion that contributes to the prior art, can be embodied in the form of a software product. This computer software product can be stored in a computer-readable storage medium, such as ROM / RAM, a magnetic disk, or an optical disk, and includes a number of instructions for causing a computer device (such as a personal computer, server, or network device) to execute the methods described in each embodiment or certain portions of the embodiments.

[0184] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the various embodiments of the present invention.

Claims

1. A method for detecting volatilization of medicinal materials based on gas chromatography, characterized in that: include: The water-containing medicinal material volatiles are input into the nanoporous structure adsorption layer at the inlet of the gas chromatograph to adsorb water molecules to obtain dehydrated medicinal material volatiles; Inputting a preset carrier gas flow into the dehydrated medicinal material volatiles for mixing to generate volatiles in an airflow mixed state; Inputting the volatile matter in the mixed state of the airflow into a preset micro-filled column separation channel to physically separate the volatile components in the mixed state of the airflow to obtain separated volatile components; The separated volatile components are input into a plurality of preset thermal conductivity synchronous detection units for parallel detection to generate multi-channel detection signals for performing medicinal material volatilization detection; The water-containing medicinal material volatiles are input into the nanoporous structure adsorption layer at the inlet of the gas chromatograph to adsorb water molecules to obtain dehydrated medicinal material volatiles, including: Inputting the volatiles of the medicinal materials containing water into the nanoporous structure adsorption layer at the inlet of the gas chromatograph, wherein the nanoporous structure adsorption layer is composed of multiple layers of nanopores with preset pore sizes; In the multiple layers of nanopores with preset pore sizes, the volatiles of the aqueous medicinal material are screened by particle size based on the first layer of nanopores to generate preliminary filtered volatiles; In the multi-layer nanopores with preset pore sizes, the primary filtered volatiles are subjected to water molecule affinity capture based on the second layer of nanopores to generate dehydrated intermediate volatiles; In the multiple layers of nanopores with preset pore sizes, the dehydrated intermediate volatiles are hydrophobically transported based on the third layer of nanopores to generate dehydrated medicinal material volatiles.

2. The method according to claim 1, characterized in that In the multi-layer nanopores with preset pore sizes, the water molecules of the initially filtered volatiles are captured by affinity based on the second layer of nanopores to generate dehydrated intermediate volatiles, comprising: Performing ionic group modification on the surface of the second layer of nanopores in the multi-layer nanopores with preset pore sizes to generate a modified surface; inputting the preliminarily filtered volatiles to the modified surface for dynamic contact treatment and residence diffusion treatment to generate volatiles in a diffusion equilibrium state; triggering the electrostatic attraction between the water molecule groups and the water ion groups in the volatile matter in the diffusion equilibrium state to generate volatile matter bonded with water molecules; The volatile matter after the bonded water molecules is introduced into a preset gas flow channel, and the non-bonded volatile components of the volatile matter after the bonded water molecules are separated by a carrier gas shear operation, and the non-bonded volatile components are used as intermediate volatiles after dehydration.

3. The method according to claim 1, characterized in that Inputting a preset carrier gas flow into the dehydrated medicinal material volatiles for mixing to generate volatiles in an airflow mixed state, comprising: The flow rate of the preset carrier gas flow is adjusted based on the preset flow control valve to generate a stable flow carrier gas; The dehydrated medicinal material volatiles are input into a preset constant temperature mixing chamber for heating to generate preheated volatiles; In the preset constant temperature mixing chamber, the stable flow carrier gas and the preheated volatiles are subjected to swirl motion to generate preliminary mixed volatiles; The preliminary mixed volatiles are subjected to mechanical disturbance treatment to generate a homogenized mixed airflow, and the homogenized mixed airflow is used as the airflow mixed-state volatiles.

4. The method according to claim 1, wherein The volatile matter in the mixed state of the airflow is input into a preset micro-filled column separation channel, and the volatile components in the mixed state of the airflow are physically separated to obtain separated volatile components, including: Inputting the volatile matter in the mixed state of the airflow into the inlet of a preset micro-filled column separation channel to generate volatile matter in the channel; In the predetermined micro-filled column separation channel, volatiles in the channel are subjected to surface adsorption and desorption cycles based on a predetermined densely packed medium to generate volatiles with differentiated migration speeds; Migrating the volatiles with differentiated migration speeds in a preset gradient pressure field to generate spatially separated volatile components; collecting the spatially separated volatile components at the outlet of the preset micro-filled column separation channel to obtain outlet-collected volatile components; The volatile components collected at the outlet are sorted according to a time series to generate separated volatile components.

5. The method according to claim 4, characterized in that Migrating the volatiles with differentiated migration speeds in a preset gradient pressure field to generate spatially separated volatile components, comprising: Inputting the volatiles with differentiated migration speeds into the starting position of the gradient pressure field in the preset micro-filled column separation channel to generate pressure field-activated volatiles; Applying the migration driving pressure difference in the preset gradient pressure field to the pressure field-acting volatiles to generate migrating flow volatiles; During the movement of the migrating volatiles, the migration rates of different components in the migrating volatiles are differentiated based on the migration velocity differentiation characteristics of the migrating volatiles to generate position-shifted volatiles; Continuously performing a migration process on the position-shifted volatiles until they migrate to a preset migration distance to generate spatially distributed volatiles; At the end position of the preset micro-packing column separation channel, a first type of volatile component with a fast migration speed and a second type of volatile component with a slow migration speed in the spatially distributed volatiles are intercepted according to the spatial distribution differences of each component in the spatially distributed volatiles to generate spatially separated volatile components.

6. The method according to claim 1, wherein The separated volatile components are input into a plurality of preset thermal conductivity synchronous detection units for parallel detection to generate multi-channel detection signals for performing medicinal material volatilization detection, including: distributing the separated volatile components into a plurality of preset thermal conductivity detection chambers to generate chamber-loaded volatiles; In each of the preset thermal conductivity detection chambers, volatiles are loaded into the chamber to perform heat conduction exchange with a preset thermal element to generate a temperature disturbance state; detecting a resistance change of a preset thermal conductivity synchronous detection unit caused by the temperature disturbance state, and generating a unit electrical signal of the preset thermal conductivity detection chamber; Synchronous signal integration is performed on the electrical signals of each unit to generate a multi-channel detection signal for performing medicinal material volatilization detection.

7. A gas chromatograph-based medicinal material volatilization detection system, used to perform the gas chromatograph-based medicinal material volatilization detection method according to any one of claims 1 to 6, characterized in that: include: The adsorption module is used to input the water-containing medicinal material volatiles into the nanoporous structure adsorption layer at the gas chromatograph inlet to adsorb water molecules to obtain dehydrated medicinal material volatiles; A mixing module, configured to input a preset carrier gas flow into the dehydrated medicinal material volatiles for mixing, thereby generating volatiles in a mixed airflow state; A separation module, configured to input the volatile matter in the mixed state of the airflow into a preset micro-filled column separation channel, and physically separate the volatile components in the volatile matter in the mixed state of the airflow to obtain separated volatile components; The detection module is used to input the separated volatile components into multiple preset thermal conductivity synchronous detection units for parallel detection, generate multi-channel detection signals, and perform medicinal material volatilization detection.

8. A computing device, characterized in that It comprises a processing component and a storage component; the storage component stores one or more computer instructions; the one or more computer instructions are used to be called and executed by the processing component to implement a medicinal material volatilization detection method based on gas chromatography as described in any one of claims 1 to 6.

9. A computer storage medium, characterized in that A computer program is stored, and when the computer program is executed by a computer, the method for detecting volatilization of medicinal materials based on gas chromatography as described in any one of claims 1 to 6 is implemented.

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