Self-mineralization antibacterial aggregate adhesive and application thereof

By preparing a condensed adhesive cross-linked polypropyleneamine hydrochloride and polyacid salt, the existing bone adhesives have solved the problems of low adhesion strength, poor biocompatibility and insufficient anti-infection performance when fixing fracture fragments, and achieved better fracture fixation and antibacterial properties.

CN120514906APending Publication Date: 2025-08-22SUZHOU UNIV
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Patent Information

Application Number
CN202510530046.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-04-25
Publication Date
2025-08-22

AI Technical Summary

Technical Problem

When fixing fracture fragments, existing bone adhesives have problems such as low adhesion strength, poor biocompatibility, insufficient osteogenic performance and insufficient anti-infection performance. Synthetic adhesives have a risk of cytotoxicity, while natural adhesives have poor mechanical properties.

Method used

Polypropyleneamine hydrochloride and polyacid saline aqueous solution are mixed to form agglomerate by crosslinking positive and negative charges, and self-mineralized antibacterial agglomerate adhesive is prepared, which has injectability, shape adaptability, antibacterial and self-mineralization properties.

Benefits of technology

It achieves better injectability, shape adaptability, adhesion and antibacterial properties, improves the fixation effect of fracture fragments and bone repair effect, and reduces the risk of bacterial infection.

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Abstract

The invention belongs to the field of bone repair, and particularly relates to a self-mineralization antibacterial aggregate adhesive and application thereof. Polyallylamine hydrochloride with positive charges and polyacid salt with negative charges are mainly used as raw materials, a condensation body is formed in a positive and negative charge cross-linking physical mode, and the polyacid salt is at least one of tripolyphosphate, polyaspartate and polysilicate. The self-mineralization antibacterial aggregate adhesive has excellent injectability and shape adaptability, can effectively fix small-size and irregular-shape fracture fragments, remarkably improves biocompatibility, adhesion strength, osteogenesis performance and antibacterial ability, and comprehensively overcomes many limitations of a traditional adhesive in bone repair.
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