Intracranial electrode carrying bracket

Abstract

The application provides an intracranial electrode carrying support, belonging to the technical field of neural intervention and brain-computer interface; the intracranial electrode carrying support comprises a support body, the support body is integrally provided with a narrow support part and a signal collecting part, an electrode piece for collecting signals is arranged on the outside of the signal collecting part, and the radial dimension of the narrow support part is smaller than that of the signal collecting part; in operation, the support body in a compressed state is automatically expanded after being delivered to a target position, the narrow support part is used for supporting a narrow part of a blood vessel, and the signal collecting part is used for supporting the electrode piece to fully contact the wall of the blood vessel at a non-narrow part to collect signals; and the application mainly solves the technical problems that the existing intracranial electrode carrying support is unstable in signal collection at a narrow part of a blood vessel and the electrode is easily interfered by deposits at the narrow part.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of neural intervention and brain-computer interface, and particularly relates to an intracranial electrode bearing support. BACKGROUND

[0002] The intracranial electrode bearing support is a device related to brain electrical monitoring or brain-computer interface, mainly used for fixing electrodes and collecting brain electrical signals, and has important applications in the fields of brain electrical treatment, electroencephalogram examination and brain-computer interface technology.

[0003] In the field of brain-computer interface technology, the intracranial electrode bearing support is a support that can be implanted into the brain through blood vessels. The support is provided with electrode pieces for collecting signals, and provides an invasive signal collection or electrical stimulation method for the brain-computer interface. For example, the Stentrode device developed by Synchron Company. It is compressed into a catheter, put into the jugular vein from the neck, the catheter winds through the blood vessels, and the support is released after reaching the motor cortex of the brain. The contact points of the electrode pieces on the support will tightly adhere to the blood vessel wall of the selected position of the brain. The support is connected to a device implanted in the chest cavity by a lead wire for providing power and data transmission, and the external device can convert the brain signals into computer commands. This method has the potential to treat a wide range of neurological diseases such as Parkinson's disease and epilepsy through neural regulation methods such as electrical stimulation, and can also help patients with frozen shoulder and paralysis to achieve thought typing and control external devices.

[0004] The electrodes on the existing intracranial electrode bearing support are generally uniformly distributed on the support. Due to different patient body conditions, the implantation position of some patients may have a blood vessel stenosis. At this time, if the intracranial electrode bearing support is implanted at this position, due to the existence of deposits in the blood vessel wall of the stenosis position, the electrode pieces at this position are difficult to stably collect signals due to being blocked by the deposits or poor contact.

[0005] Therefore, it is necessary to provide an improved technical solution for the above-mentioned deficiencies of the prior art. SUMMARY

[0006] The purpose of the present application is to provide an intracranial electrode bearing support to solve the technical problems of unstable signal collection at the blood vessel stenosis position and the electrodes being easily disturbed by the deposits at the stenosis position in the prior art intracranial electrode bearing support.

[0007] In order to achieve the above-mentioned purpose, the intracranial electrode bearing support of the present application provides the following technical solution:

[0008] The application discloses an intracranial electrode bearing stent, which comprises a stent body, the stent body is provided with a narrow support part and a signal collecting part, the outer side of the signal collecting part is provided with an electrode sheet for collecting signals, and the radial dimension of the narrow support part is smaller than that of the signal collecting part; in operation, the stent body in a compressed state is automatically expanded after being delivered to a target position, the narrow support part is used for supporting a narrow part of a blood vessel, and the signal collecting part is used for supporting the electrode sheet to fully contact the wall of the blood vessel at a non-narrow part to collect signals.

[0009] As a further optimization technical scheme, the narrow support part is located at the middle part of the stent body, and the signal collecting part is located at both ends of the narrow support part.

[0010] As a further optimization technical scheme, the electrode sheet is fixedly arranged on the outer side wall of the signal collecting part and arranged along the axial direction and / or the circumferential direction of the signal collecting part.

[0011] As a further optimization technical scheme, the stent body is provided with a protection unit for isolating the electrode sheet from blood.

[0012] As a further optimization technical scheme, the protection unit comprises a sealing inner membrane, the sealing inner membrane is arranged on the inner side wall of the signal collecting part, and the width direction of the sealing inner membrane covers all positions of the electrode sheet, and both ends of the sealing inner membrane are provided with a blocking part for blocking blood from contacting the electrode sheet.

[0013] As a further optimization technical scheme, the blocking part is a stop strip, the stop strip is located on the outer side wall of the sealing inner membrane and extends to the outer side wall of the stent body.

[0014] As a further optimization technical scheme, the protection unit further comprises a sealing outer membrane, the sealing outer membrane is arranged on the outer side wall of the signal collecting part and covers all positions of the electrode sheet in the width direction, the sealing outer membrane is sealingly connected with the sealing inner membrane, and the sealing outer membrane is provided with a through hole for the electrode sheet to pass through.

[0015] As a further optimization technical scheme, both ends of the sealing outer membrane are sealingly connected with the sealing inner membrane through the stop strip.

[0016] As a further optimization technical scheme, the through hole is fixedly connected with a fixing ring, and the fixing ring is used for sealingly clamping the outer periphery of the electrode sheet.

[0017] As a further optimization technical scheme, the protection unit comprises a sealing inner membrane, the sealing inner membrane is arranged on the inner side wall of the stent body, and both ends of the sealing inner membrane are bent and extended to the outer side wall of the stent body by a certain distance.

[0018] Beneficial effects: the stent body of the application has a narrow support part and a signal collection part, the electrode sheet is arranged only in the signal collection part, the signal collection part is fully unfolded at the non-narrow part, ensuring effective contact of the electrode sheet with the blood vessel wall and avoiding the blood vessel narrow part, so that the electrode sheet can avoid contact with the blood vessel deposits, significantly reducing signal interference and improving signal-to-noise ratio, thus more conveniently and accurately collecting signals; the narrow support part is used to support the narrow part of the blood vessel, so as to realize intervention treatment of the narrow part while collecting signals, and can also slow down the aggravation of the blood vessel stenosis caused by the stimulation of the stent body to the blood vessel.

[0019] Further, the stent body is integrally provided with the narrow support part and the signal collection part, and the narrow support part is located at the middle part and the signal collection part is located at the two ends, so that the narrow support part can accurately embed the blood vessel narrow part and provide stable support after the stent body is expanded, avoiding displacement of the stent body in the blood vessel. BRIEF DESCRIPTION OF DRAWINGS

[0020] The drawings accompanying the specification of this application serve to provide further understanding of the application, and the illustrative embodiments of the application and their descriptions serve to explain the application, and do not constitute improper limitations on the application. Among them:

[0021] Figure 1 It is an overall structure schematic diagram of one embodiment of the intracranial electrode carrying stent of the application;

[0022] Figure 2 It is a top view of one embodiment of the intracranial electrode carrying stent of the application;

[0023] Figure 3 It is an enlarged schematic diagram of the signal collection part of one embodiment of the intracranial electrode carrying stent of the application;

[0024] Figure 4 It is a partial sectional view schematic diagram of one embodiment of the intracranial electrode carrying stent of the application;

[0025] Figure 5 It is Figure 4 It is an enlarged structure schematic diagram of part A;

[0026] Figure 6 It is a sealing inner membrane arrangement schematic diagram of another embodiment of the intracranial electrode carrying stent of the application.

[0027] In the drawings: 100, stent body; 110, narrow support part; 120, signal collection part; 200, electrode sheet; 300, sealing inner membrane; 400, stop bar; 500, sealing outer membrane; 600, fixing ring. DETAILED DESCRIPTION

[0028] The technical solutions in the embodiments of the present application will be clearly and completely described below. Obviously, the described embodiments are only some of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art belong to the scope of protection of the present application.

[0029] In the description of the present application, the orientation or positional relationship indicated by the terms "longitudinal", "transverse", "upper", "lower", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", and the like is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present application, and does not require the present application to be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application. The terms "connected", "connected" used in the present application should be understood broadly, for example, can be fixed connection, can also be detachable connection; can be directly connected, can also be indirectly connected through intermediate components, and those skilled in the art can understand the specific meaning of the above terms according to the specific circumstances. In addition, the term "proximal end" refers to the end close to the operator, and the term "distal end" refers to the end away from the operator.

[0030] The present application will be described in detail below with reference to the drawings and in conjunction with the embodiments. It should be noted that the embodiments in the present application and the features in the embodiments can be combined with each other without conflict.

[0031] The shapes and sizes of the components in the drawings do not reflect the true proportions of the product, but only serve to illustrate the content of the present application.

[0032] The present application provides an intracranial electrode carrying support, which comprises a support body 100, the support body 100 is provided with a narrow support part 110 and a signal acquisition part 120, the outer side of the signal acquisition part 120 is arranged with an electrode sheet 200, and the radial dimension of the narrow support part 110 is smaller than that of the signal acquisition part 120. In operation, the support body 100 in the compressed state is automatically expanded after being delivered to the target position, the narrow support part 110 supports the stenosis part of the blood vessel, and the signal acquisition part 120 is used to support the electrode sheet 200 to fully contact the blood vessel wall of the non-stenosis part to collect signals. In addition, a protection unit is arranged on the support body 100 to isolate the electrode sheet 200 from the blood, so as to ensure the structural integrity and electrical performance stability of the electrode sheet 200 during long-term implantation. The present application can adapt to the stenosis structure of the blood vessel, ensure the stability of signal acquisition, reduce the interference of the sediment in the stenosis part, integrate the functions of support, signal acquisition and treatment, and is suitable for scenes such as electroencephalogram monitoring and brain-computer interface.

[0033] Embodiment 1

[0034] As Figure 1 , Figure 2As shown, the intracranial electrode carrying support of the embodiment comprises a support body 100 made of a nickel-titanium alloy material and having shape memory characteristics, which can be delivered through a catheter in a compressed state, and automatically expand to restore a preset shape under the action of body temperature after reaching the target blood vessel position. The support body 100 is integrally formed with a narrow support part 110 and a signal acquisition part 120, the mesh density and mesh size of the narrow support part 110 are smaller than those of the signal acquisition part 120, so that the support force of the narrow support part 110 is greater than that of the signal acquisition part 120, thereby meeting the support requirements.

[0035] In the embodiment, the narrow support part 110 is located at the middle of the support body 100, and the signal acquisition part 120 is located at both ends of the narrow support part 110, and the radial dimension of the signal acquisition part 120 is smaller than the radial dimension of the signal acquisition part 120. This structural design makes the signal acquisition part 120 act as a stop structure after the support body 100 expands, thereby enabling the narrow support part 110 to be stably supported in the blood vessel and avoiding displacement of the support body 100 in the blood vessel.

[0036] An electrode sheet 200 is fixedly arranged on the outer side wall of the signal acquisition part 120. The electrode sheet 200 is arranged in the axial direction and / or the circumferential direction of the signal acquisition part 120. In the embodiment, the electrode sheet 200 is made of a metal material with good biocompatibility and is arranged in one column in the axial direction of the signal acquisition part 120, and six are uniformly distributed in the circumferential direction of each column. In other embodiments, two or more columns are arranged in the axial direction of the signal acquisition part 120, and four to six are uniformly arranged in the circumferential direction to form a multi-channel signal acquisition array, which can comprehensively collect electroencephalogram signals. Alternatively, in some specific use scenarios, the electrode sheet 200 can also be arranged only in the axial direction to meet the use requirements.

[0037] In this way, in actual work, the support body 100 in a compressed state is automatically expanded after being delivered to the target position, the narrow support part 110 is used to support the narrow part of the blood vessel, and the signal acquisition part 120 is used to support the electrode sheet 200 to fully contact the blood vessel wall of the non-narrow part to collect signals.

[0038] Further, in order to fully protect the electrode sheet 200, a protection unit is arranged on the support body 100 to isolate the electrode sheet 200 from blood.

[0039] Because the blood contains a variety of corrosive substances, long-term direct contact can cause the electrode sheet 200 material to deteriorate and performance to decline. In addition, the ions, proteins and other components in the blood contact the electrode sheet 200, and these components can also interfere with the electrode sheet 200 signal, significantly reducing the signal-to-noise ratio of signal acquisition, reducing the brain-computer interface control accuracy. The protection unit can separate the electrode sheet 200 from the blood, reduce the probability of electrode sheet 200 being corroded, prolong the effective working time of the electrode sheet 200, and thus prolong the service life of the entire intracranial electrode carrying bracket, reduce the risk of secondary surgery replacement for the patient, and reduce the interference of blood on the electrode sheet 200 signal.

[0040] As shown in Figure 3 , Figure 4 , Figure 5 In the present embodiment, the protection unit of the signal acquisition part 120 at either end of the bracket body 100 includes a sealed inner membrane 300, which is fixedly attached to the inner side wall of the signal acquisition part 120 and covers all positions of the electrode sheet 200 in the width direction of the signal acquisition part 120. The sealed inner membrane 300 is provided with a stop bar 400 at both ends as a blocking component to prevent blood from contacting the electrode sheet 200. The stop bar 400 is located on the outer side wall of the sealed inner membrane 300 and extends outward to not less than the outer side wall of the bracket body 100. The purpose of this design is that when the bracket body 100 fully expands to support the blood vessel after being placed in the blood vessel, because the blood vessel has soft elasticity, the bracket body 100 extrudes the blood vessel outward, at this time, the outer side wall of the stop bar 400 will press the blood vessel wall, so that the outer side wall of the stop bar 400 forms a seal with the blood vessel wall, and the electrode sheet 200 is located between the two stop bars 400, thereby effectively isolating the blood from the electrode sheet 200.

[0041] In the present embodiment, the stop bar 400 is an important component for achieving sealed connection between the sealed inner membrane 300 and the blood vessel wall in the protection unit, and its assembly method and structural characteristics are crucial to the overall sealing performance of the protection unit and the adaptability of the bracket.

[0042] In the assembly method, the stop bar 400 is formed in an integrated structure with the sealing inner membrane 300 and the stent body 100 by using a liquid casting process. The specific process is as follows: first, the sealing inner membrane 300 is fixed at a preset position on the inner side wall of the signal acquisition part 120 of the stent body 100; then, the elastic material in a liquid state is accurately cast on the outer side walls of both ends of the sealing inner membrane 300, and the liquid material is naturally cooled to form the stop bar 400 with a preset shape. At this time, the stop bar 400 is tightly combined with the sealing inner membrane 300 and the stent body 100 as a whole, so as to ensure the sealing property of the stop bar 400, the sealing inner membrane 300 and the stent body 100. The material of the stop bar 400 is selected to be a medical polyurethane elastomer, such as TPU-95A. This material has excellent soft elasticity and biocompatibility. When the stent body 100 is in a compressed delivery state, the stop bar 400 can elastically deform with the radial contraction of the stent body 100, so as to avoid the breakage or disengagement from the sealing outer membrane 500 due to excessive rigidity. When the stent body 100 is delivered to the target position and expands, the stop bar 400 can synchronously elastically recover to tightly abut against the edge of the sealing outer membrane 500, so as to ensure the effectiveness of the sealing connection and prevent blood from seeping from the connection between the sealing inner membrane 300 and the sealing outer membrane 500. Meanwhile, the medical polyurethane elastomer has good chemical stability and will not react with blood components. In addition, the medical polyurethane elastomer has excellent fatigue resistance and can withstand the possible slight deformation of the stent body 100 in the body for a long time, so as to ensure the long-acting sealing effect of the protection unit.

[0043] Further, when the sealing performance requirement is higher, the protection unit further has a sealing outer membrane 500. The sealing outer membrane 500 at any one end of the stent body 100 is arranged on the outer side wall of the signal acquisition part 120 and covers all positions of the electrode sheet 200 on the signal acquisition part 120 in the width direction. The two ends of the sealing outer membrane 500 are sealingly connected with the sealing inner membrane 300 through the stop bar 400. The sealing outer membrane 500 is provided with through holes through which the electrode sheet 200 passes, so as to ensure the direct contact of the electrode sheet 200 with the blood vessel.

[0044] Further, in order to avoid the deformation of the through hole leading to the sealing failure with the electrode sheet 200, a fixing ring 600 made of silica gel is fixed in the through hole. The fixing ring 600 is tightly sleeved on the outer periphery of the electrode sheet 200, so as to realize the sealing connection between the electrode sheet 200 and the sealing outer membrane 500 and prevent the blood from seeping in.

[0045] Further, the outer side wall of the narrow support part 110 is coated with a drug for treating vascular stenosis, such as a rapamycin drug coating. The drug is gradually released by a slow-release technology, so as to inhibit the proliferation of vascular smooth muscle cells and delay the progression of stenosis.

[0046] The use process of the intracranial electrode carrying stent of the embodiment is as follows: the stenosis position and size of the blood vessel are determined through cerebral angiography before the operation, and the intracranial electrode carrying stent of a matching specification is selected; the stent body 100 in a compressed state is loaded to the distal end of a delivery catheter during the operation, and is sent to the target stenosis position of the cerebral blood vessel through a femoral artery puncture path; after the position is confirmed to be accurate, the catheter is withdrawn to release the stent, the stent is automatically inflated under the action of body temperature, the stenosis supporting part 110 is embedded into the stenosis section of the blood vessel and releases the drug, and the signal acquisition part 120 is inflated to make the electrode sheet 200 tightly adhere to the normal blood vessel wall; the electroencephalogram collected by the electrode sheet 200 is received through an external controller after the operation, and the real-time monitoring or brain-computer interface control function is realized.

[0047] Embodiment 2

[0048] As shown in Figure 6 , the embodiment provides a different structure of the protection unit, and different from the embodiment 1, in the embodiment, the protection unit only includes the sealing inner membrane 300, the sealing inner membrane 300 is fixedly arranged on the inner side wall of the stent body 100, and both ends are curved and extended upwards and fixed on the outer side wall of the stent body 100 at a set distance, it needs to be noted that the set distance is generally selected from the distance from the end of the stent body 100 to the electrode sheet 200 closest to the end, and can be appropriately lengthened according to the sealing requirement, and generally, the greater the distance is set, the better the sealing property of the sealing inner membrane 300 is, and therefore, the distance is determined according to the actual production condition.

[0049] In this way, after the stent body 100 is fully inflated to support the blood vessel in the blood vessel, the stent body 100 extrudes the blood vessel outwardly due to the soft elasticity of the blood vessel, at this time, both ends of the stent body 100 will inevitably slightly sink into the inside of the blood vessel wall, and therefore, the part of the sealing inner membrane 300 arranged on the outer side wall of the stent body 100 will form a seal with the blood vessel, so that the blood can be effectively isolated from the electrode sheet 200. In addition, in this way, the sealing inner membrane 300 covers both ends of the stent body 100, and the stimulation of the stent body 100 to the blood vessel can be further reduced.

[0050] In summary, the intracranial electrode carrying stent provided by the application can effectively adapt to the stenosis structure of the blood vessel, guarantee the signal acquisition stability, integrate the supporting, signal acquisition and treatment functions, and has high clinical application value.

[0051] It can be understood that the above description is only exemplary, and the embodiments of the application do not limit this.

[0052] The above is only a preferred embodiment of the application, and is not intended to limit the application, and any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the application is within the protection scope of the application.

Claims

1. An intracranial electrode support bracket, characterized in that: The invention comprises a stent body (100), wherein the stent body (100) has an integrally arranged stenosis support portion (110) and a signal acquisition portion (120), an electrode sheet (200) for collecting signals is arranged on the outer side of the signal acquisition portion (120), and the radial dimension of the stenosis support portion (110) is smaller than the radial dimension of the signal acquisition portion (120); when in operation, the stent body (100) in a compressed state is automatically expanded after being transported to a target position, the stenosis support portion (110) is used to support the stenosis portion of the blood vessel, and the signal acquisition portion (120) is used to support the electrode sheet (200) to fully contact the blood vessel wall at a non-stenosis portion to collect signals.

2. The intracranial electrode support according to claim 1, characterized in that: The narrow support portion (110) is located in the middle of the stent body (100), and the signal collection portion (120) is located at both ends of the narrow support portion (110).

3. The intracranial electrode support according to claim 1, characterized in that: The electrode sheet (200) is fixedly arranged on the outer side wall of the signal collection part (120) and arranged along the axial direction and / or circumferential direction of the signal collection part (120).

4. The intracranial electrode support according to any one of claims 1 to 3, characterized in that: The support body (100) is provided with a protection unit for isolating the electrode sheet (200) from blood.

5. The intracranial electrode supporting bracket according to claim 4, characterized in that: The protection unit comprises a sealing inner membrane (300), which is arranged on the inner side wall of the signal acquisition part (120) and covers the positions of all electrode sheets (200) in the width direction. Both ends of the sealing inner membrane (300) are provided with barrier components for preventing blood from contacting the electrode sheets (200).

6. The intracranial electrode support according to claim 5, characterized in that: The barrier component is a stop bar (400), which is located on the outer side wall of the sealing inner membrane (300) and extends outward to a position not lower than the outer side wall of the bracket body (100).

7. The intracranial electrode support according to claim 6, characterized in that: The protection unit further comprises a sealing outer film (500), the sealing outer film (500) being arranged on the outer side wall of the signal acquisition portion (120) and covering the positions of all electrode sheets (200) in the width direction, the sealing outer film (500) being sealedly connected to the sealing inner film (300), and through holes for the electrode sheets (200) to pass through being provided between the sealing outer film (500) and the electrode sheets (200).

8. The intracranial electrode support according to claim 7, characterized in that: Both ends of the sealing outer film (500) are sealedly connected to the sealing inner film (300) via stop bars (400).

9. The intracranial electrode supporting bracket according to claim 7, characterized in that: A fixing ring (600) is fixedly connected in the through hole, and the fixing ring (600) is used for sealing and is clamped on the outer periphery of the electrode sheet (200).

10. The intracranial electrode supporting bracket according to claim 4, characterized in that: The protection unit comprises a sealing inner membrane (300), which is arranged on the inner side wall of the bracket body (100), and has two ends that bend upward and extend to a set distance from the outer side wall of the bracket body (100).

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