Ointment for treating cervical and lumbar bone pain and preparation method thereof

Abstract

The invention discloses ointment for treating cervical and lumbar bone pain and a preparation method thereof. The ointment is prepared from the following medicinal components in parts by weight: 300 parts of wild radix clematidis, 200 parts of raw rhubarb, 200 parts of fructus gardeniae, 150 parts of ligusticum wallichii, 150 parts of coriaria nepalensis, 100 parts of asiatic toddalia root, 100 parts of cortex erythrinae, 50 parts of borneol, 150 parts of turmeric and 150 parts of turmeric. Wherein except the borneol, the other medicines are ground into powder and sieved to be fine for later use. Therefore, traditional Chinese medicine components such as the wild radix clematidis, the raw rhubarb and the cape jasmine which have the effects of dispelling wind, dissipating blood stasis and promoting blood circulation to arrest pain are crushed and sieved to be fine and then fused with base materials such as the vaseline, the liquid paraffin and the beewax, borneol is added under the low-temperature condition to form the ointment, and the ointment can directly act on the focus when being applied to the affected part, so that local blood circulation is improved, inflammation is relieved, and stasis resistance is improved; the traditional Chinese medicine composition can quickly relieve pain and recover functions, avoids the limitation of the traditional oral medicine or a high-temperature decoction ointment preparation process, overcomes the problems of single component, poor permeability, complicated operation and the like of the existing external ointment, and improves the efficacy exertion efficiency and the use convenience.

Description

Technical Field

[0001] The present invention relates to the technical field of ointments, in particular to an ointment for treating cervical and lumbar vertebrae pain and a preparation method thereof. Background Art

[0002] Currently, oral medications, physical therapy, blocked injections, and topical patches are commonly used clinically to treat chronic pain, limited mobility, and other symptoms caused by diseases such as cervical spondylosis, lumbar disc herniation, and bone hyperplasia. Among them, topical ointments have gradually become one of the preferred auxiliary treatments for patients due to their advantages such as ease of use, clear site of action, and minimal side effects. Most existing topical ointments use traditional Chinese medicine ingredients in combination with an oily base to achieve the purpose of relaxing muscles and tendons, reducing swelling, and relieving pain. Some products can be used in conjunction with hot compresses during treatment to further enhance the drug's penetration.

[0003] However, existing ointments still have many shortcomings in practical applications. First, some ointments have a single formula ingredient and lack the synergistic effect of promoting blood circulation and removing blood stasis and dispelling wind and relieving pain, resulting in unclear or slow efficacy, which is difficult to meet the demand for continuous relief of pain caused by chronic bone diseases; second, some products lack scientificity in the base material ratio, the paste has high viscosity or poor permeability, it is difficult to fully release the active ingredients, and it is not easy to fix at low temperatures or during the application process, affecting patient comfort and treatment compliance; in addition, some ointments have a rough production process and the particle size of the powder is different, which can easily cause the paste to stratify or precipitate, which is not conducive to the stable release of the drug effect. Summary of the Invention

[0004] The present invention aims to solve one of the technical problems in the related art at least to a certain extent.

[0005] To this end, the purpose of the present invention is to propose an ointment for treating cervical and lumbar spine pain and a preparation method thereof. The ointment is an external-use ointment composed of a variety of Chinese medicinal ingredients and a scientifically proportioned base material, and adopts the preparation process of "ultra-fine powder + temperature-controlled melting of base material + low-temperature stirring and mixing" to ensure that the medicinal ingredients are evenly dispersed and stably released. The ointment is used in an application manner, which is easy to operate. Combined with hot compress, it can further enhance the drug penetration and effect intensity. This technical solution effectively solves the problems of existing ointments such as single ingredients, poor permeability, unstable efficacy and inconvenience in use, and significantly improves the therapeutic effect of cervical and lumbar spine pain and the patient experience.

[0006] To achieve the above-mentioned object, the present invention proposes an ointment for treating cervical and lumbar vertebrae pain, which comprises the following medicinal ingredients in proportion by weight: 300 parts of wild clematis, 200 parts of raw rhubarb, 200 parts of gardenia, 150 parts of ligusticum chuanxiong, 150 parts of rock mulberry, 100 parts of dragon palm blood, 100 parts of pittosporum tobira bark, 50 parts of borneol and 150 parts of turmeric; except for the borneol, the other medicinal ingredients are powdered, sieved and set aside.

[0007] Specifically, the ointment also includes the following base components: 500 parts of vaseline, 1000 parts of liquid paraffin, and 100 parts of beeswax; after the base components are heated and melted, they are mixed with the medicinal powder and borneol, and stirred evenly to prepare the ointment.

[0008] Specifically, the particle size of the drug powder is controlled to be above 120 meshes to improve the skin permeability and drug release rate of the ointment.

[0009] Specifically, borneol is added at the end after the base material is melted, and the temperature is kept no higher than 60° C. during stirring to prevent borneol from volatilizing and affecting the efficacy of the medicine.

[0010] A method for preparing an ointment for treating cervical and lumbar vertebrae pain comprises the following steps:

[0011] S1. Wash and dry wild clematis, raw rhubarb, gardenia, ligusticum chuanxiong, mulberry, feilong palm blood, and pittosporum bark, then grind and sieve to a fine powder;

[0012] S2. Mix vaseline, liquid paraffin, and beeswax and heat to 80-100°C to fully melt to form a base;

[0013] S3. Slowly add the powder obtained in step S1 to the base and stir evenly;

[0014] S4. When the temperature drops to about 60°C, add borneol and continue stirring until the mixture is evenly mixed and cooled to form a paste.

[0015] Specifically, the cooling temperature of the ointment is controlled at room temperature (20-30° C.), and a uniform state is maintained during the stirring process to avoid sedimentation of the components.

[0016] Specifically, the mixing process of the drug powder and the base material is mechanical stirring and is carried out in a closed container to prevent impurities or moisture from entering and affecting the efficacy of the drug.

[0017] Specifically, the ointment is applied to the affected area in the form of an application. When used, it is spread evenly on the middle part of the plaster and covered with gauze. The application time is 4 to 5 hours and it should be changed once.

[0018] Specifically, during the application process, covering the outside of the plaster with a hot water bag or hot compress device of appropriate temperature can help promote the penetration and absorption of the active ingredients of the drug and improve the efficacy.

[0019] Specifically, its indications include but are not limited to soft tissue injuries, blood stasis and chronic pain caused by cervical spondylosis, lumbar disc herniation, bone hyperplasia, etc. It has the effects of dispelling wind and blood stasis, promoting blood circulation and relieving pain. Pregnant women are prohibited from using it.

[0020] Additional aspects and advantages of the present invention will be set forth in part in the description which follows and, in part, will be obvious from the description which follows, or may be learned through practice of the present invention. DETAILED DESCRIPTION

[0021] The following describes embodiments of the present invention in detail, wherein identical or similar reference numerals throughout represent identical or similar elements or elements having identical or similar functions. These are intended to explain the present invention and are not to be construed as limiting the present invention. On the contrary, the embodiments of the present invention include all variations, modifications, and equivalents that fall within the spirit and scope of the appended claims.

[0022] The present invention provides an ointment for treating cervical and lumbar vertebrae pain and a preparation method thereof.

[0023] The ointment for treating cervical and lumbar vertebrae pain in an embodiment of the present invention comprises the following medicinal ingredients in proportions by weight: 300 parts of wild clematis, 200 parts of raw rhubarb, 200 parts of gardenia, 150 parts of ligusticum chuanxiong, 150 parts of mulberry, 100 parts of dragon palm blood, 100 parts of pittosporum bark, 50 parts of borneol and 150 parts of turmeric. Except for borneol, the remaining medicines are powdered and sieved for later use.

[0024] It should be noted that the 300 parts of wild Clematis chinensis, 200 parts of raw rhubarb, 200 parts of gardenia, 150 parts of Chuanxiong, 150 parts of rock mulberry, 100 parts of dragon palm blood, 100 parts of pittosporum tobira bark, 50 parts of borneol and 150 parts of turmeric described in this embodiment, except for borneol, the remaining drugs are all washed, dried and crushed, and screened through a 120-mesh sieve to ensure that the powder is fine and uniform, which is conducive to full dispersion and penetration absorption in the base material, thereby improving the drug release efficiency and skin permeability. The various medicinal materials are used synergistically. Wild Clematis chinensis promotes blood circulation, relieves pain, and dredges the meridians, serving as the main ingredient. Raw rhubarb clears heat and promotes bowel movements, promoting blood circulation and removing blood stasis, thus relieving soft tissue congestion and swelling. Gardenia jasminoides clears heat and relieves restlessness, reduces swelling and relieves pain, and helps improve local inflammatory reactions. Chuanxiong promotes blood circulation and qi, dispels wind and relieves pain, and enhances blood circulation. Morus alba and Pittosporum tobira bark possess excellent anti-rheumatic and analgesic effects. Feilong Zhangxie, with its significant blood stasis-dispersing and analgesic abilities, assists other drugs in achieving their therapeutic effects. Borneol, a transdermal absorption enhancer, is added to the paste in the final stage, enhancing the penetration efficiency of other medicinal ingredients while also providing a cooling and analgesic effect, as well as guiding the medicinal ingredients into the body. Through the above compound formulation and processing methods, the overall efficacy can not only promote blood circulation, remove blood stasis, dispel wind and cold, but also quickly relieve swelling and pain in the bone and joint areas, thereby achieving effective topical treatment for orthopedic diseases such as cervical spondylosis and lumbar disc herniation.

[0025] The ointment also comprises the following base material components: 500 parts of vaseline, 1000 parts of liquid paraffin and 100 parts of beeswax. The base materials are heated and melted, mixed with the medicine powder and borneol, and stirred evenly to prepare the ointment.

[0026] It should be noted that the 500 parts of vaseline, 1000 parts of liquid paraffin, and 100 parts of beeswax described in this embodiment, wherein vaseline is used as the main ointment base, has good skin-friendliness and sealing properties, can form a protective film on the skin surface, prevent moisture loss and prolong the residence time of the drug in the affected area, liquid paraffin is used as an auxiliary matrix, giving the ointment suitable fluidity and softness, enhancing its spreadability on gauze or plaster cloth, and improving the comfort and compliance of use. The addition of beeswax not only improves the consistency and stability of the ointment, but also has natural antibacterial, anti-inflammatory and repair effects, which helps to protect the affected skin and prevent external irritation. After the three are mixed in proportion, they are heated and melted at 80°C to 100°C to form a homogeneous and transparent base system. Subsequently, the sieved Chinese medicine powder is slowly added under continuous stirring to fully disperse and stably suspend the medicinal ingredients in the base to avoid precipitation or agglomeration. When the base temperature drops to about 60°C, borneol is quickly added and its volatile properties are used to integrate it into the system at low temperatures to ensure that its active ingredients are not destroyed by high temperatures and can be evenly distributed throughout the paste, further enhancing the skin permeability and targeted absorption efficiency of the active ingredients. Through the combination of the above-mentioned base material ratio and the temperature-controlled stirring process, the resulting ointment has good ductility, permeability and efficacy stability, providing an ideal medium environment for the sustained release and local absorption of the Chinese medicine ingredients, thereby effectively improving the clinical application effect of the ointment in the treatment of cervical and lumbar spine-related pain diseases.

[0027] The particle size of the drug powder is controlled above 120 mesh to improve the skin permeability and drug release rate of the ointment.

[0028] It should be noted that the particle size of the medicinal powder described in this embodiment is controlled to be above 120 mesh. Through fine grinding and multi-stage screening processes, the medicinal powder particles are made uniform and fine, which significantly increases the specific surface area of ​​the drug, facilitates full dispersion and suspension in the paste base, and increases its contact area with the skin surface, thereby promoting faster release and penetration of the active ingredients into the subcutaneous tissue during the application process, thereby enhancing local efficacy. In addition, the fine particle structure can more smoothly penetrate into the local lesion area through microchannels such as skin pores and sweat gland channels, and is particularly suitable for penetrating treatment required for deep soft tissue lesions such as cervical spondylosis and lumbar disc herniation. The refined powder can also effectively avoid the formation of uneven particle agglomeration in the paste, reduce patient discomfort during use, improve the smoothness and compliance of the application, and help improve the user experience and treatment compliance. At the same time, strict control of the powder particle size also helps the paste maintain a stable state during storage, avoid sedimentation and stratification, and ensure consistent and uniform efficacy each time it is used, thereby providing technical support for achieving continuous and stable release of the ointment and lasting efficacy.

[0029] Borneol is added at the end after the base material is dissolved, and the temperature is kept below 60°C during stirring to prevent borneol from volatilizing and affecting the efficacy.

[0030] It should be noted that the borneol described in this embodiment is added at the end after the base material is melted, and the paste temperature is strictly controlled to be no higher than 60°C during stirring. This is mainly because borneol has strong volatility and heat sensitivity, and its main medicinal ingredients such as borneol and borneol are easily evaporated and lost at high temperatures, thereby affecting the therapeutic effect of the ointment. Adding borneol at a low temperature stage can not only avoid the volatilization of its effective ingredients, but also retain its pharmacological effects of cooling and relieving pain, opening the orifices and penetrating the skin, and guiding the medicine into the interior to the greatest extent, so that the role of borneol in the ointment can be more fully exerted. In addition, low-temperature stirring can ensure that borneol is fully mixed and evenly distributed with the entire paste matrix, avoiding crystallization or uneven precipitation of borneol caused by high temperature, resulting in uneven distribution of medicinal effects. By controlling the temperature to stir below 60°C, the volatile components of borneol are retained to improve skin permeability, and its stable presence in the paste is ensured, thereby further enhancing the absorption capacity of other medicinal ingredients on the skin surface and the conduction efficiency to the lesion area, effectively improving the therapeutic depth and efficacy sustainability of the overall ointment.

[0031] Specifically, in the process of processing medicinal materials, cleaning, drying, crushing and screening technology of more than 120 meshes are used to ensure that the powder particles are fine and uniform, which is conducive to the full dispersion and stable release of the drug effect in the base material, significantly improving the skin permeability and targeted absorption efficiency. In the preparation process, vaseline, liquid paraffin and beeswax are selected in a scientific proportion to form a base system, which is heated to 80-100 ° C to form a uniform paste base, and then the powder is slowly added and stirred evenly to make the drug ingredients evenly suspended in the paste to avoid agglomeration and sedimentation. Borneol is added when the base material is cooled to no more than 60 ° C, which prevents its volatilization while retaining its cooling transdermal and drug-inducing effects, further improving the overall penetration depth and drug release intensity. When the ointment is used, it is applied to the painful area with gauze. The drug is slowly released in a warm environment and acts on the lesion area through the skin, achieving a comprehensive therapeutic effect of dispelling wind and cold, promoting blood circulation and relieving pain, and relieving soft tissue compression and inflammatory reactions. It is particularly suitable for bone and joint diseases such as cervical spondylosis, lumbar disc herniation, and bone hyperplasia. This working mechanism effectively solves the problems of existing topical ointments such as single ingredients, poor permeability, uneven efficacy, and inconvenient operation through formula optimization, particle refinement, and temperature control process improvements on the basis of traditional patches, significantly improving clinical treatment efficiency and patient comfort and compliance.

[0032] A method for preparing an ointment for treating cervical and lumbar vertebrae pain comprises the following steps:

[0033] S1. Wash and dry wild Clematis chinensis, raw rhubarb, gardenia, ligusticum chuanxiong, mulberry, dragon palm blood, and pittosporum bark, crush them separately, and sieve them into fine powder. S2. Mix vaseline, liquid paraffin, and beeswax, heat them to 80-100°C to fully melt them to form a base. S3. Slowly add the powder obtained in step S1 to the base and stir evenly. S4. When the temperature drops to about 60°C, add borneol and continue stirring until the mixture is evenly mixed, and cool to form a paste.

[0034] Furthermore, the cooling temperature of the ointment is controlled at room temperature of 20 to 30°C, and a uniform state is maintained during the stirring process to avoid component sedimentation. The mixing process of the powder and the base material is mechanically stirred and carried out in a closed container to prevent impurities or moisture from entering and affecting the efficacy.

[0035] It should be noted that, in the step S1 described in the present embodiment, wild Clematis chinensis, raw rhubarb, gardenia, ligusticum chuanxiong, rock mulberry, dragon palm blood, and pittosporum bark are selected and cleaned to remove impurities and sediment, and then low-temperature dried at 60-70°C to retain the activity of the effective ingredients in the medicinal materials, and then pulverized and screened through 120 meshes to obtain fine and uniform medicinal powder, ensuring that the drug has good dispersibility and skin penetration ability in the paste; S2. Vaseline, liquid paraffin and beeswax are put into a heating device in proportion and mixed, and the heating temperature is controlled within the range of 80-100°C to fully melt the three base materials to form a uniform and transparent oily base, wherein vaseline provides good ductility and sealing, liquid paraffin imparts softness and permeability, and beeswax enhances the consistency and adhesion of the paste, and the three synergistically constitute a stable, skin-friendly base system; S3. While maintaining the base material in a molten state, the medicinal powder prepared in step S1 is slowly added thereto in portions, and the base material is mechanically stirred. The system is continuously stirred with a speed controlled at 300-500rpm to prevent caking, agglomeration or local overheating, ensuring that the Chinese medicine powder is evenly suspended and stably distributed throughout the paste. S4. The temperature is gradually lowered during the stirring process. When the paste temperature drops to about 60°C, borneol is quickly added. Taking advantage of its volatile and rapidly soluble properties at low temperatures, borneol is evenly distributed in the paste under sufficient stirring conditions, retaining its cooling, transdermal and drug-inducing effects. Furthermore, the ointment continues to be stirred to room temperature of 20-30°C during the cooling stage to prevent the powder from settling or stratifying due to temperature changes, ensuring the uniform distribution of the active ingredients in the finished product. At the same time, the entire mixing and cooling process is completed in a closed container, which can effectively prevent impurities, water vapor or microorganisms in the air from entering the paste, ensuring the purity and storage stability of the medicine. Through the above-mentioned optimized process, the prepared ointment reaches a good level in terms of texture, uniformity, drug release and skin penetration, significantly improving the application effect of the drug in external treatment and user experience.

[0036] Specifically, through the fine processing and scientific proportioning of Chinese medicinal materials, combined with an optimized base material system and temperature-controlled preparation process, the sustained release and efficient penetration of the active ingredients on the surface of the skin are achieved, showing a significant therapeutic effect. Its working principle is: by washing, low-temperature drying, crushing and screening wild Clematis chinensis, raw rhubarb, gardenia, Chuanxiong, rock mulberry, dragon palm blood, pittosporum bark and other medicinal materials to more than 120 meshes, a high-fineness powder is obtained, which greatly improves the specific surface area and dispersion performance of the drug, so that it has good distribution stability and transdermal absorption capacity in the base material, and then heating and melting vaseline, liquid paraffin and beeswax to form a skin-friendly and ductile matrix, which can form a protective film on the skin surface, prolong the drug's action time, and improve compliance and comfort. The drug powder is slowly added to the base material through mechanical stirring and kept evenly dispersed to avoid agglomeration, thereby ensuring that the medicinal ingredients are evenly distributed in each unit area of ​​the paste. Borneol is added when the temperature drops to 60°C, and its volatile active ingredients are retained through rapid stirring at low temperature, which not only enhances the local cooling and analgesic effect, but also promotes the transdermal penetration and targeted absorption of other drugs. It is finally cooled into a paste at room temperature and continuously stirred until it is fully formed. The entire process is carried out in a closed system to prevent impurities, moisture or air contamination, ensuring the purity and stability of the ointment. Compared with traditional topical ointments with problems such as coarse powder, uneven distribution, weak penetration, inconvenience in use and unstable efficacy, this technical solution effectively improves the ointment's efficacy stability, transdermal efficiency and patient experience through systematic optimization of the medicinal material processing method, base material ratio, temperature control and mixing process. It is particularly suitable for external auxiliary treatment of bone and joint pain diseases such as cervical spondylosis and lumbar disc herniation.

[0037] It should be understood that the ointment is applied to the affected area in the form of an application. When used, it should be spread evenly on the middle part of the plaster and covered with gauze. The application time is 4 to 5 hours and it should be changed once. During the application process, a hot water bag or hot compress device with appropriate temperature is added to the outside of the plaster to help promote the penetration and absorption of the active ingredients of the drug and improve the efficacy. Its indications include but are not limited to soft tissue injuries, blood stasis and chronic pain caused by cervical spondylosis, lumbar disc herniation, bone hyperplasia, etc. It has the effects of dispelling wind and blood stasis, promoting blood circulation and relieving pain. Pregnant women are prohibited from using it during use.

[0038] Example 1:

[0039] Compatibility principles and simulated clinical verification

[0040] The present embodiment prepares ointment based on the original formula of Miao medicine blood-activating and analgesic plaster, and analyzes the efficacy compatibility logic and mechanism of action of each medicinal material. Take 300 parts of wild clematis root, 200 parts of raw rhubarb, 200 parts of gardenia, 150 parts of chuanxiong, 150 parts of rock mulberry, 100 parts of dragon palm blood, 100 parts of pittosporum tobira bark, 50 parts of borneol and 150 parts of turmeric to form a prescription, without adding any other ingredients. Except borneol, the above-mentioned medicinal materials are dried, crushed and sieved into a fine powder, added in the base material (500 parts of vaseline, 1000 parts of liquid paraffin, 100 parts of beeswax) mixed in proportion and heated and melted, and stirred. After extinguishing the fire and cooling slightly, add borneol fine powder and continue stirring, so that it is fully dissolved and fused. After cooling, a black plaster matrix is ​​formed. The gained plaster is a uniform black ointment, and the smell is fragrant and strong, and a layer of adhered medicine film can be formed on the skin surface after coating.

[0041] The pharmacological effects and compatibility logic of each medicinal material in the formula are as follows:

[0042] Clematis chinensis (pungent and warm): good at dispelling wind and dampness, unblocking meridians and relieving pain, and is an important medicine for treating rheumatic pain.

[0043] Raw rhubarb (bitter and cold): has the effects of purging heat and detoxifying, cooling blood and reducing swelling. External application can eliminate local inflammation and swelling, promote blood circulation and disperse blood stasis, accelerate the absorption of blood stasis, and relieve tenderness.

[0044] Gardenia (bitter and cold): clears heat and purges fire, promotes dampness and cools blood, and can reduce swelling, heat and pain in the affected area; local application can reduce inflammatory exudate and help relieve redness, swelling and pain caused by blood stasis.

[0045] Chuanxiong (pungent and warm): good at promoting blood circulation, activating qi and relieving pain, and is good at treating blood stasis headaches and blood stasis pain. It can be used as an adjuvant to enhance the effect of promoting blood circulation and removing blood stasis, promote blood circulation in the affected area, and work together with Clematidis to exert an analgesic effect.

[0046] Yanma Sang (pungent and warm): a commonly used medicine in Miao medicine, with the functions of dispelling wind, dredging meridians, relieving pain and dispersing blood stasis.

[0047] In this prescription, Morus alba and Clematis chinensis work together to enhance the effect of dispelling wind and dampness, and together with Ligusticum chuanxiong, they help to promote blood circulation, thereby relieving pain in muscles and bones.

[0048] Feilong Zhangxue (pungent and warm): functions to disperse blood stasis and stop bleeding, dispel wind and dampness, reduce swelling and relieve pain.

[0049] It is good at treating bruises and rheumatic joint pain. When combined with Chuanxiong, Morus alba, etc., it can enhance the effects of promoting blood circulation, removing blood stasis, reducing swelling and relieving pain, and provide strong support for stubborn pain.

[0050] Pittosporum bark (bitter and flat): good at dispelling rheumatism, relaxing muscles and tendons, and treating low back and knee pain, rheumatic pain, etc. In prescriptions, it is combined with Clematis chinensis to focus on relaxing muscles and relieving pain, relieving muscle spasms, and improving limited joint movement.

[0051] Borneol (pungent and cool): It has the effects of invigorating the mind, reducing swelling and relieving pain. As a drug messenger, borneol is highly volatile. When applied topically, it promotes the transdermal absorption of other drugs directly to the affected area, imparting a cooling and analgesic effect to the affected area, quickly relieving pain.

[0052] Taking all the above into consideration, the formula of this plaster follows the principle of "monarch, minister, assistant and envoy" in traditional Chinese medicine, with each drug working synergistically: the monarch drug, Clematis chinensis, specializes in dispelling wind and dampness and relieving pain; the minister drugs, such as Chuanxiong, Feilong Zhangxie, and Yanma Morus, assist in promoting blood circulation, removing blood stasis, reducing swelling and relieving pain, and together enhance the analgesic effect; the adjuvant drugs, such as Rhubarb and Gardenia, clear away heat and detoxify, disperse blood stasis and reduce swelling, prevent heat accumulation in the affected area, and alleviate swelling and pain; the envoy drug, borneol, guides the drugs directly to the meridians of the affected area, enhancing the overall efficacy. The combination of these drugs combines the functions of dispelling wind, dispersing cold, removing dampness, promoting blood circulation, reducing swelling, and relieving pain, achieving both symptomatic and root treatment for pain caused by rheumatism and blood stasis, rapidly alleviating symptoms and promoting recovery.

[0053] Simulated clinical indications and application reactions: This plaster has good adaptability for various muscle and bone pains, such as chronic pain caused by cervical spondylosis, lumbar disc herniation, etc. When applying, spread an appropriate amount of plaster evenly on the affected skin:

[0054] Cervical spondylosis: Patients experience neck stiffness and pain radiating to the shoulders and arms. A few hours after applying the plaster, a localized warmth and slight tingling sensation gradually develops, reflecting the drug's blood circulation and meridian unblocking effects, indicating that blocked meridians are being unblocked. A day later, patients generally experience reduced neck stiffness, pain relief, and improved head and neck mobility. Continued daily application can gradually alleviate pain symptoms caused by cervical bone spurs and soft tissue inflammation.

[0055] Lumbar disc herniation: Patients experience lower back pain accompanied by radiating sciatica. Applying the plaster to the affected area of ​​the waist and related meridians will initially produce a slight local cooling sensation that then turns to warmth, indicating that the drug has penetrated deep into the muscles and bones. After several applications, the patient's lower back and leg pain is relieved, and their mobility is improved. This is because the blood-activating and blood-stasis-removing herbs in the plaster reduce the pressure and inflammation of the nerve roots caused by the herniated disc, while the wind-removing and dampness-removing herbs relieve local muscle tension and edema around the nerve roots. A typical course of treatment is one week. Following treatment, the patient's lower limb numbness and pain are significantly improved, and lower back stability is enhanced.

[0056] The simulated case study demonstrates that the synergistic effects of the various drugs in this formula produce significant local pharmacological responses: mild warmth or redness at the application site often indicate improved local blood circulation and drug penetration; the patient's pain and stiffness are rapidly alleviated, demonstrating that the combination exerts its therapeutic effect by eliminating the underlying causes (wind, cold, dampness, and blood stasis) and improving the local pathological condition. This result validates the synergistic effect of the original formula and demonstrates its excellent therapeutic efficacy for muscle and bone pain disorders such as cervical spondylosis and lumbar disc herniation.

[0057] Example 2:

[0058] Typical patient usage and efficacy observation

[0059] This example is based on the same formula and takes the usage of a typical patient as an example to illustrate the application method, treatment course arrangement and clinical efficacy of the blood-activating and analgesic plaster, and verify its blood-activating and analgesic, wind-dispelling and blood-stasis-dispersing effects.

[0060] Patient: A 55-year-old male with a long-term desk job had developed chronic low back pain over the past two years. Radiographic examinations revealed mild lumbar vertebral bone hyperplasia (bone spurs) and lumbar muscle strain. Symptoms included recurrent dull pain in the lower back, aggravated by prolonged sitting or rainy weather, and morning stiffness, but no significant lower extremity numbness.

[0061] Application Instructions: Instruct the patient to wipe the affected area of ​​the waist with a hot towel to open the pores. Heat approximately 20 grams of this plaster in an oil bath to soften it. Apply evenly to a gauze patch (approximately 10 cm x 10 cm, sufficient to cover the painful area). Apply the gauze patch to the affected area and secure the edges with medical tape. Replace the patch every 24 hours. Keep the affected area dry during this period to prevent moisture from affecting its effectiveness.

[0062] Usage Cycle: One course of treatment is 7 days. Patients should adhere to two courses of treatment (14 days total) and then evaluate efficacy. Apply the patch daily without interruption during treatment. Mild itching or redness is a normal reaction to the medication and can be tolerated by the patient. If irritation is significant, the interval between changes may be extended or treatment may be paused for one day before continuing.

[0063] Observational feedback: Approximately two hours after the first application, the patient felt a gradual warmth and relaxation in her lower back. The pain in the previously sore area began to ease, and the tension in her lumbar muscles decreased. That evening, the patient felt her lower back relax more easily, and the pain when turning over was reduced by approximately 30%. With continued daily application, by the third day, the patient had noticeably lessened morning stiffness, and the frequency and intensity of lower back pain after prolonged daytime sitting had decreased. By the end of the first course of treatment (day 7), the patient's persistent lower back pain had essentially disappeared, with only mild discomfort associated with excessive exertion. Skin examination revealed slight redness and warmth at the application site, with no signs of damage or overexertion. A second course of treatment continued, and around day 10, the patient reported free lower back movement, with only mild soreness after prolonged sitting, which resolved with rest. By the end of day 14, the patient's lower back pain score had decreased from an initial 6 points (on a 0–10 scale) to 1–2 points, with minimal restrictions on daily activities.

[0064] Results: The results demonstrate that the plaster, without the addition of any other ingredients, fully demonstrated its efficacy in promoting blood circulation, removing blood stasis, and relaxing tendons and alleviating pain. The significant relief of the patient's low back pain indicates that the plaster promoted local blood circulation, improved soft tissue inflammation and blood stasis caused by bone hyperplasia, and thus alleviated nerve stimulation (reflecting a "blood circulation and pain relief" effect). Furthermore, the patient's sensitivity to climate change decreased, and morning stiffness resolved, reflecting the plaster's wind-dispelling and dampness-removing properties, warming and unblocking tendons and veins (reflecting a "wind-dispelling and blood stasis-removing" effect). The patient did not use any other oral analgesics throughout treatment, and the pain relief can be attributed to the external therapeutic effects of the plaster, further demonstrating the rationality and effectiveness of the original formulation: the components synergize in the prescribed proportions, producing the desired therapeutic effect without the need for additional ingredients. Furthermore, the plaster's preparation and application are simple and feasible, with good patient compliance. The plaster requires only pulverization and mixing, is easily applied, and allows for free movement after adhesive tape fixation, without significant side effects. Therefore, this technical solution shows excellent operability and clinical practical value under the compatibility of raw materials.

[0065] In summary, the traditional Chinese medicine ingredients with the effects of dispelling wind, dispersing blood stasis, promoting blood circulation and relieving pain, such as wild Clematis chinensis, raw rhubarb, and Gardenia jasminoides, are crushed and sieved, and then fused with base materials such as vaseline, liquid paraffin, and beeswax, and borneol is added under low temperature conditions to form an ointment. Applying it to the affected area can directly act on the lesion, achieve rapid pain relief and functional recovery by enhancing local blood circulation, relieving inflammation, and improving blood stasis, avoiding the limitations of traditional oral medications or high-temperature decoction and ointment-making processes, and overcoming the problems of existing external ointments such as single ingredients, poor permeability, and cumbersome operation, thereby significantly improving the efficiency of drug efficacy and convenience of use.

[0066] Although the embodiments of the present invention have been shown and described above, it will be understood that the above embodiments are exemplary and are not to be construed as limitations on the present invention. A person skilled in the art may change, modify, replace and deform the above embodiments within the scope of the present invention.

Claims

1. An ointment for treating cervical and lumbar vertebrae pain, characterized in that: The invention comprises the following medicinal ingredients in proportion by weight: 300 parts of wild clematis root, 200 parts of raw rhubarb, 200 parts of gardenia, 150 parts of ligusticum chuanxiong, 150 parts of mulberry, 100 parts of dragon palm blood, 100 parts of pittosporum tobira bark, 50 parts of borneol and 150 parts of turmeric; except for the borneol, the other medicinal ingredients are powdered and sieved for later use.

2. The ointment for treating cervical and lumbar vertebrae pain according to claim 1, characterized in that: The ointment also includes the following base material components: 500 parts of vaseline, 1000 parts of liquid paraffin and 100 parts of beeswax. The base materials are heated and melted, mixed with the medicine powder and borneol, and stirred evenly to prepare the ointment.

3. The ointment for treating cervical and lumbar vertebrae pain according to claim 1 or 2, characterized in that: The particle size of the drug powder is controlled above 120 mesh to improve the skin permeability and drug release rate of the ointment.

4. The ointment for treating cervical and lumbar vertebrae pain according to claim 3, characterized in that: Borneol is added at the end after the base material is dissolved, and the temperature is kept below 60°C during stirring to prevent borneol from volatilizing and affecting the efficacy.

5. A method for preparing an ointment for treating cervical and lumbar vertebrae pain, characterized in that: The following steps are involved: S1. Wash and dry wild clematis, raw rhubarb, gardenia, ligusticum chuanxiong, mulberry, feilong palm blood, and pittosporum bark, then grind and sieve to a fine powder; S2. Mix vaseline, liquid paraffin, and beeswax and heat to 80-100°C to fully melt to form a base; S3. Slowly add the powder obtained in step S1 to the base and stir evenly; S4. When the temperature drops to about 60°C, add borneol and continue stirring until the mixture is evenly mixed and cooled to form a paste.

6. The method for preparing the ointment for treating cervical and lumbar vertebrae pain according to claim 5, wherein: The cooling temperature of the ointment is controlled at room temperature (20-30°C), and it is kept in a uniform state during the stirring process to avoid sedimentation of the ingredients.

7. The method for preparing the ointment for treating cervical and lumbar vertebrae pain according to claim 5 or 6, characterized in that: The mixing process of the drug powder and the base material is mechanically stirred and carried out in a closed container to prevent impurities or moisture from entering and affecting the efficacy of the drug.

8. The ointment for treating cervical and lumbar vertebrae pain according to claim 1, characterized in that: The ointment is applied to the affected area in the form of a patch. When used, it should be spread evenly on the middle part of the plaster and covered with gauze. The application time is 4 to 5 hours and it should be changed once.

9. The ointment for treating cervical and lumbar vertebrae pain according to claim 8, characterized in that: During the application process, covering the outside of the plaster with a hot water bag or hot compress device of appropriate temperature can help promote the penetration and absorption of the active ingredients of the drug and improve the efficacy.

10. The ointment for treating cervical and lumbar vertebrae pain according to claim 9, characterized in that: Its indications include but are not limited to soft tissue injuries, blood stasis and chronic pain caused by cervical spondylosis, lumbar disc herniation, bone hyperplasia, etc. It has the effects of dispelling wind and blood stasis, promoting blood circulation and relieving pain. Pregnant women are prohibited from using it.