Application of umbilical cord mesenchymal stem cells combined with exosome in treatment of neurological function deficiency after brain injury

The treatment plan of umbilical cord mesenchymal stem cells combined with high-purity exosomes solves the problem that existing technologies are difficult to improve neurological dysfunction after traumatic brain injury, achieves more effective nerve repair and reduces inflammatory response, and has the advantages of easy availability of raw materials, simple methods and good biosafety.

CN120585884APending Publication Date: 2025-09-05WUXI CHUYUANSAIER BIOTECHNOLOGY CO LTD
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Patent Information

Application Number
CN202510918923.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-07-04
Publication Date
2025-09-05

AI Technical Summary

Technical Problem

Existing methods for treating traumatic brain injury are difficult to effectively improve neurological deficits, and existing drug intervention strategies have limitations in repairing brain tissue defects.

Method used

The treatment regimen uses umbilical cord mesenchymal stem cells combined with exosomes, which are administered via intravenous injection or local intracerebral injection. Tangential flow filtration and precipitation methods are used to extract high-purity exosomes to promote nerve repair and reduce inflammatory responses.

Benefits of technology

It improves the survival rate of brain-damaged cells, reduces the secretion level of inflammatory factor TNF-α, and promotes the expression of neurotrophic factor NGF, thereby effectively improving neurological dysfunction after brain injury.

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Abstract

The invention belongs to the technical field of biology, and particularly discloses application of an umbilical cord mesenchymal stem cell combined exosome in treatment of neurological function deficiency after brain injury, a tangential flow filtration method and a precipitation method are combined for extraction of an ultrapure exosome, and the umbilical cord mesenchymal stem cell and the exosome are combined for use, so that the survival rate of brain injury cells is increased, and the neurological function deficiency after brain injury is treated. According to the application, the secretion level of an inflammatory factor TNF-alpha is reduced, and meanwhile, the expression of a neurotrophic factor NGF is promoted, so that the repair and improvement of the neurological function after the brain injury are realized, and the application can be used for treating the neurological function deficiency after the brain injury. Compared with a traditional treatment method, the umbilical cord mesenchymal stem cells and the exosome are combined for use, so that the neurological function deficiency can be more effectively improved, the inflammatory response is relieved, the neural restoration is promoted, and a new thought and a new method are provided for clinical treatment of brain injury patients.
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