Optimization method of processing technology of rice water-processed rhizoma atractylodis

Abstract

The invention relates to the field of traditional Chinese medicines, in particular to an optimization method of a rice water-prepared rhizoma atractylodis processing technology, which is characterized in that on the basis of a single factor test, in combination with a Box-Behnken design-response surface method, and by comprehensive evaluation indexes of atractydin, beta-eudesmol and atractylenolide I, the rice water-prepared rhizoma atractylodis processing technology is optimized. Five factors including the rice-water ratio, the rice water dosage, the moistening time, the stir-frying temperature and the stir-frying time are investigated, and the optimal processing technology of the rice water processed rhizoma atractylodis is determined by calculating the weight coefficient and the comprehensive score of each index through an analytic hierarchy process and a CRITIC method.

Description

Technical Field

[0001] The invention relates to the field of traditional Chinese medicine, and in particular to a method for optimizing the processing technology of atractylodes lancea prepared with rice water. Background Art

[0002] Atractylodes lancea (Thunb.) DC., also known as Atrctylodes chinensis (DC.) Koidz., is a plant of the Asteraceae family. It boasts the properties of dehumidifying, strengthening the spleen, dispelling wind and cold, and improving eyesight. Originally known as "shu," it was first mentioned in the Shennong Bencao Jing (Classic of Materia Medica) as a top-grade herb. Later, in Tao Hongjing's Bencao Jing Jizhu (Collected Works of Materia Medica), shu was divided into "baizhu" (white atractylodes) and "atractylodes." Atractylodes lancea primarily contains sesquiterpenes (such as β-cineole and atractylol), polyvinyl acetylenes (such as atractylodesin and atractylol), and small amounts of phenols and glycosides. Current research suggests that Atractylodes lancea can regulate gastrointestinal motility, provide antibacterial and anti-inflammatory benefits, promote food digestion and absorption, and influence the structure of the intestinal flora.

[0003] Raw Atractylodes lancea is commonly used to dry dampness and strengthen the spleen, but its strong drying properties require processing to reduce this dryness. Historically, Atractylodes lancea has been processed using methods such as vinegar, stir-frying, steaming, and traditional methods. Currently, the Chinese Pharmacopoeia primarily includes the method of stir-frying with bran. However, research on the processing technology of Atractylodes lancea prepared with rice water is not currently included in the pharmacopoeia, resulting in inaccurate processing endpoints and making quality control difficult during the processing of Atractylodes prepared with rice water. Summary of the Invention

[0004] In view of the deficiencies in the above-mentioned prior art, the object of the present invention is to provide a method for optimizing the processing technology of Atractylodes lancea prepared with rice water. The present invention is based on single-factor experiments and combines Box-Behnken design-response surface methodology. Atractylodesin, β-eudesmol and atractylodes lactone I are used as comprehensive evaluation indicators to investigate five factors: rice-water ratio, rice water dosage, steaming time, frying temperature and frying time. The weight coefficient and comprehensive score of each indicator are calculated using the hierarchical analysis method and the CRITIC method to determine the optimal processing technology of Atractylodes lancea prepared with rice water.

[0005] In order to solve the above technical problems, the present invention adopts the following technical solutions: A method for optimizing the processing technology of Atractylodes lancea prepared with rice water comprises the following steps: The raw product of Atractylodes lancea is crushed to obtain Atractylodes lancea powder, and the Atractylodes lancea powder is subjected to alcohol extraction and volatile oil extraction to obtain Atractylodes lancea alcohol extract and Atractylodes lancea volatile oil.

[0006] Thermal analysis technology was used to analyze the pyrolysis characteristics of Atractylodes lancea powder, Atractylodes lancea ethanol extract and Atractylodes lancea volatile oil, and the processing temperature range of Atractylodes lancea was preliminarily obtained based on the results of pyrolysis characteristic analysis.

[0007] Based on the preliminary obtained processing temperature range of Atractylodes lancea, the atractylodesin, β-eudesmol and atractylodes lactone I contents were used as evaluation indicators. The weight coefficients of each evaluation indicator were determined by AHP and CRITIC respectively. The weight coefficients determined by AHP and CRITIC were combined to calculate the comprehensive weight of each evaluation indicator, and then the comprehensive score calculation formula was obtained based on the comprehensive weight results.

[0008] The rice-to-water ratio in rice swill, rice water dosage, processing temperature and processing time were used as single-factor variables, and the evaluation indicators of Atractylodes lancea under different rice-to-water ratios, rice water dosage, processing temperature and processing time were comprehensively scored using the comprehensive scoring calculation formula.

[0009] The indicators for response surface optimization experiment were determined based on the comprehensive scoring results. The response surface optimization experiment was conducted with the rice-water ratio, rice-water dosage, steaming time, processing temperature and processing time as indicators and the comprehensive score as the response value to determine the optimal processing technology of Atractylodes lancea with rice water.

[0010] In a preferred embodiment of the present invention, when determining the processing temperature range of Atractylodes lancea by pyrolysis characteristics, the temperature at which the maximum weight loss range of the volatile oil component of Atractylodes lancea is located is used as the starting temperature of the processing temperature range, and the ending temperature of the volatile oil component of Atractylodes lancea is used as the ending temperature of the processing temperature range.

[0011] In a preferred embodiment of the present invention, the processing temperature range for initially obtaining Atractylodes lancea is 170°C to 210°C.

[0012] In a preferred embodiment of the present invention, the method for calculating the weight coefficient of AHP is as follows: according to the active ingredients in Atractylodes lancea and the main incremental components after processing and the leaching rate, each indicator is quantitatively ranked in the order of atractylodesin>β-eudesmol>>atractylodes lactone I.

[0013] In a preferred embodiment of the present invention, the order of weight coefficients determined by AHP is: atractylodesin > β-eudesmol > atractylodes lactone I.

[0014] In a preferred embodiment of the present invention, the calculation formula of the comprehensive weight is: ,in, w A is the weight of each indicator determined by AHP, w j The weights of each indicator determined by CRITIC.

[0015] In a preferred embodiment of the present invention, the response surface optimization experiment was performed using Design Expert 13.0 software according to the central composite design principle to obtain the quadratic multiple regression equation Y = 0.6803 + 0.0093A - 0.027B + 0.0149C + 0.0065D - 0.0255AB + 0.0032AC + 0.0266AD - 0.023BC - 0.0136BD - 0.0272CD - 0.0592A 2 -0.0497B 2 -0.0075C 2 -0.0390D 2 Among them, A represents the ratio of rice to water, B represents the amount of rice to water, C represents the processing temperature, and D represents the processing time.

[0016] In a preferred embodiment of the present invention, the optimal processing technology of Atractylodes lancea with rice water is as follows: the mass ratio of rice to water in rice water is 1:60, the amount of rice water is 15 mL, the processing temperature is 201°C, and the processing time is 30 min.

[0017] In a preferred embodiment of the present invention, the thermal analysis method is thermogravimetric analysis and differential thermogravimetric analysis.

[0018] Thermal analysis is an instrumental analytical method that accurately records the relationship between the physical and chemical properties of a substance and temperature or time under programmed temperature and a specific atmosphere. Thermal analysis techniques mainly include thermogravimetric analysis, differential thermogravimetric analysis, and differential thermal analysis.

[0019] Compared with the prior art, the present invention has the following beneficial effects: The invention adopts thermal analysis technology to analyze the pyrolysis characteristics of atractylodes lancea powder, atractylodes lancea alcohol extract and atractylodes lancea volatile oil, preliminarily obtains the processing temperature range of atractylodes lancea according to the pyrolysis characteristic analysis results, and based on the preliminarily obtained processing temperature range of atractylodes lancea, atractylodesin, β-eudesmol and atractylodes lactone I content evaluation indicators are used, and weight coefficients of each evaluation indicator are determined by AHP and CRITIC respectively. The weight coefficients determined by AHP and CRITIC are combined to calculate the comprehensive weight of each evaluation indicator, and a comprehensive score calculation formula is obtained according to the comprehensive weight result, and the rice-water ratio is used as the weight coefficient. , rice water amount, processing temperature and processing time were selected as single factor investigation variables. The comprehensive scoring calculation formula obtained by AHP-CRITIC was used to comprehensively score the evaluation indicators of Atractylodes lancea under different rice water ratios, rice water amount, processing temperature and processing time. According to the comprehensive scoring results, the indicators for response surface optimization experiment were determined. With rice water ratio, rice water amount, steaming time, processing temperature and processing time as indicators and the comprehensive score as the response value, a response surface optimization experiment was carried out to determine the optimal processing technology of Atractylodes lancea prepared with rice water, providing theoretical support for the processing technology of Atractylodes prepared with rice water. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 This is the thermal decomposition characteristic curve of the original medicinal material of Atractylodes lancea.

[0021] Figure 2 This is the pyrolysis characteristic curve of the volatile components of Atractylodes lancea.

[0022] Figure 3 This is the thermal decomposition characteristic curve of the alcohol extract of Atractylodes lancea.

[0023] Figure 4 This is a three-dimensional response surface plot of rice-to-water ratio, rice-to-water dosage and comprehensive score.

[0024] Figure 5 This is a three-dimensional response surface diagram of rice-water ratio, processing temperature and comprehensive score.

[0025] Figure 6 This is a three-dimensional response surface diagram of the processing temperature, processing time and comprehensive score.

[0026] Figure 7 This is the three-dimensional response surface plot of rice-water ratio, frying time and comprehensive score.

[0027] Figure 8 This is a three-dimensional response surface diagram of rice water dosage, processing temperature and comprehensive score.

[0028] Figure 9 This is a three-dimensional response surface plot of rice water amount, frying time and comprehensive score. DETAILED DESCRIPTION

[0029] The following is a detailed description of the technical solutions in the embodiments of the present invention, using preferred embodiments and accompanying drawings in conjunction with the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0030] It should be noted that all professional terms used in the present invention are only for the purpose of describing specific embodiments and are not intended to limit the scope of protection of the present invention. Unless otherwise specified, the various raw materials, reagents, instruments and equipment used in the following embodiments of the present invention can be purchased from the market or prepared by existing methods.

[0031] instrument STA449-F5 thermogravimetric-differential thermal analyzer (NETZSCH, Germany); AX124ZH electronic balance (Changzhou Ohaus Instrument Co., Ltd.); 800Y high-speed multifunctional pulverizer (Zhejiang Boou Electric Co., Ltd.); GZX-9140MBE electric blast drying oven (Shanghai Boxun Industrial Co., Ltd. Medical Equipment Factory); HH-2 water bath (Jerel Electric Co., Ltd., Jintan City); SHZ-Ⅲ vacuum pump (Shanghai Zhixin Experimental Instrument Technology Co., Ltd.); ABL series multifunctional herbal medicine stir-frying machine (Lanzhou Apollo Electronic Equipment Co., Ltd., specification 25 L, feed capacity ≥50 g); spectrophotometer UV-visible spectrophotometer (Shanghai Meipuda Instrument Co., Ltd.); Agilent 1260 high-performance liquid chromatograph (Agilent Corporation, USA); SYU-10-300DT ultrasonic cleaning machine (Zhengzhou Shengyuan Instrument Co., Ltd.).

[0032] Medicinal materials and reagents Atractylodes lancea (batch number: 220701, origin: Inner Mongolia, purchased from Shanxi Yuanhetang Chinese Medicine Co., Ltd.) was identified by Professor Zhang Shuosheng of Shanxi University of Traditional Chinese Medicine as the dried rhizome of Atractylodes chinensis (DC.) Koidz. of the Asteraceae family.

[0033] Atractylodesin reference substance (batch number: 15120, mass fraction > 91%); β-eudesmol reference substance (batch number: 14293, mass fraction > 95%); Atractylodes lactone I (batch number: WP23070706, mass fraction > 98%).

[0034] Example 1 A method for optimizing the processing technology of Atractylodes lancea prepared with rice water comprises the following steps: (1) The raw product of Atractylodes lancea is crushed to obtain Atractylodes lancea powder, and the Atractylodes lancea powder is subjected to alcohol extraction and volatile oil extraction to obtain Atractylodes lancea alcohol extract and Atractylodes lancea volatile oil.

[0035] Thermal analysis sample preparation S1. Preparation of raw Atractylodes lancea powder: Weigh 100 g of Atractylodes lancea, crush it, and pass it through a No. 3 sieve for later use.

[0036] S2. Preparation of Atractylodes lancea alcohol extract: 30g of powder was placed in a stoppered conical flask at a material ratio of 1:20 (g / ml). 90% methanol was added, and the flask was sealed. The weight was determined. After sonication for 45 minutes, the weight was determined again. 90% methanol was added to the final weight, and the extract was shaken and filtered. Rotary evaporation, drying, grinding, and sieving were performed.

[0037] S3. Preparation of volatile component samples of Atractylodes lancea: Extract according to Method A of the Chinese Pharmacopoeia Volatile Oil Extraction Method. Accurately weigh 50 g of raw powder and place it in a round-bottom flask. Add 10 times the amount of water. Ultrasonicate for 30 minutes and then heat under reflux to extract until the volatile oil content no longer increases. After cooling, collect the volatile oil using an EP tube.

[0038] (2) The pyrolysis characteristics of Atractylodes lancea powder, Atractylodes lancea alcohol extract and Atractylodes lancea volatile oil were analyzed by thermal analysis technology, and the processing temperature range of Atractylodes lancea was preliminarily obtained based on the results of pyrolysis characteristic analysis.

[0039] Thermal analysis testing Using simulated air (N2:O2=4:1) as the carrier gas, the volume flow rate was 60mL / min, the heating rate was 10℃ / min, and the amount of each sample was (20±5mg), and the temperature was heated from room temperature to 600℃. The pyrolysis characteristics of Atractylodes lancea powder, Atractylodes lancea alcohol extract, Atractylodes lancea volatile oil and standard products were studied under simulated air conditions. Each group of samples was tested in parallel three times. The results are as follows Figures 1 to 3 shown.

[0040] The pyrolysis stage of the original medicinal material of Atractylodes lancea is divided into two stages. The first stage is the pyrolysis stage of volatile components, which is 190℃~219℃, with a thermal weight loss rate of 19%. The second stage is the pyrolysis stage of non-volatile components, which is 251℃~346℃, with a thermal weight loss rate of 28.29%. The main pyrolysis stage of volatile components of Atractylodes lancea is 118℃~210℃, with a main thermal weight loss rate of 54.32%. The main pyrolysis stage of Atractylodes lancea alcohol extract is 110℃~171℃, with a thermal weight loss rate of 7.84%. The second pyrolysis stage is 170℃~200℃, with a thermal weight loss rate of 12.57%. At 170℃, the volatile components of Atractylodes lancea are in the range of maximum weight loss. Therefore, 170℃ is set as the starting point of the processing temperature, and the end temperature of the volatile components of Atractylodes lancea, 210℃, is regarded as the end point. Therefore, the processing temperature range is 170℃~210℃.

[0041] (3) Based on the preliminary obtained processing temperature range of Atractylodes lancea, the content of atractylodesin, β-eudesmol and atractylodes lactone I was used as the evaluation index. The weight coefficients of each evaluation index were determined by AHP and CRITIC respectively. The weight coefficients determined by AHP and CRITIC were combined to calculate the comprehensive weight of each evaluation index. The comprehensive score calculation formula was obtained through the comprehensive weight results.

[0042] Chromatographic conditions Chromatographic conditions 1: Xselect CSHTM C18 column (250 mm×4.6 mm, 5 μm); mobile phase: A (acetonitrile): B (0.1% phosphoric acid in water); gradient elution (0–9 min, 95% B; 9–14 min, 95%–30% B; 14–16 min, 30%–40% B; 16–18 min, 40%–50% B; 18–24 min, 50%–40% B; 24–30 min, 40%–30% B; 30–31 min, 30%–50% B; 31–33 min, 50–70% B; 33–40 min, 70–95% B); column temperature: 30°C; injection volume: 10 μL.

[0043] Chromatographic conditions 2: acetonitrile: 0.1% phosphoric acid water (80:20) as mobile phase; volume flow rate 1.0 mL / min; column temperature 25°C; injection volume 10 μL.

[0044] Preparation of reference solution Accurately weigh 1.7 mg of atractylodesin and 2.4 mg of atractylodes lactone I respectively and place them in a 5 ml volumetric flask, dilute to the scale with methanol, and prepare mixed reference solutions with concentrations of 0.34 mg / ml and 0.48 mg / ml respectively.

[0045] Preparation of β-eudesmol Standard Accurately weigh 0.8 mg of β-eudesmol into a 5 ml volumetric flask and dilute to the mark with methanol to prepare a test solution with a concentration of 0.16 mg / ml.

[0046] Preparation of test solution Weigh 10g each of raw Atractylodes lancea and processed Atractylodes lancea, crush them through a No. 3 sieve, accurately weigh 1g, place it in a conical flask, add 25ml of methanol, plug it and weigh it, ultrasonicate it for 30min, weigh it again, make up the missing mass with methanol, shake it well, centrifuge it (3000r15min), take the supernatant, filter it (0.45μm), and take the filtrate.

[0047] Investigation of linear relationships Pipette an appropriate amount of the mixed reference solution and dilute it 2, 10, 20, 40, and 100 times respectively. Measure according to the above chromatographic conditions and draw a standard curve with the concentration of the reference as the horizontal axis and the peak area as the vertical axis.

[0048] Take an appropriate amount of β-eudesmol reference substance and dilute it to 2, 4, 6, 8, and 10 times of the mother liquor, respectively. Determine according to the above chromatographic conditions for β-eudesmol, and draw a standard curve with the reference substance concentration as the horizontal axis and the peak area as the vertical axis.

[0049] Table 1 Linear regression equations and regression coefficients of the main active ingredients of Atractylodes lancea AHP subjective calculation weights: The AHP analytic hierarchy process (AHP) is a decision analysis method proposed by American operations researcher Satti. It can determine the relative importance of each indicator and assign quantitative weights based on the decision maker's experience. This study quantitatively ranked each indicator based on the main active ingredients in Atractylodes lancea, the main incremental components after processing, and the leaching rate. The order was atractylodesin > β-eudesmol > > atractylodes lactone I. A pairwise comparison was constructed to calculate the weight coefficients. The results showed that the weight coefficients for atractylodesin, β-eudesmol, and atractylodes lactone I were 0.53, 0.29, and 0.16, respectively. The matrix consistency ratio CI = 0.015 and the consistency ratio CR = 0.011, both of which were less than 0.1, indicating that the matrix was consistent.

[0050] CRITIC method is used to calculate weights: CRITIC method is a method that evaluates the contrast strength and conflict between indicators to obtain the weight of each indicator. The contrast strength is expressed in the form of standard deviation, and the conflict is based on the correlation between indicators. Substitute the measured data into the formula Y i =[X i -X (min) ] / [X (max) -X (min) ], Y i Expressed as a normalized value, X i Expressed as actual measured value, X (min) Expressed as the minimum value of each indicator, X (min) It is expressed as the maximum value of each indicator. The weight calculation results of each evaluation indicator are shown in Table 2.

[0051] Table 2 Calculation results of weights of each component Determination of comprehensive weight and score: Combine the weight coefficients determined by AHP method and CTITIC method to calculate the comprehensive weight (W). The specific formula is: The results are shown in Table 3, and then the comprehensive weight is substituted into the formula Calculate the composite score.

[0052] Table 3 Weight coefficients of each weight analysis method (4) The rice-water ratio, rice-water dosage, processing temperature and processing time were used as single-factor variables. The comprehensive score calculation formula obtained by AHP-CRITIC was used to comprehensively score the evaluation indicators of Atractylodes lancea under different rice-water ratios, rice-water dosages, processing temperatures and processing times. A single-factor experiment was conducted with the comprehensive score as the evaluation indicator. The results are shown in Table 4.

[0053] The impact of rice-water ratio on overall score AHP-CRITIC was used to comprehensively evaluate the index components of Atractylodes lancea at different rice-water ratios. The effects of different rice-water ratios (1:50, 1:60, and 1:70) on the comprehensive score were investigated, while other parameters, such as the processing time and temperature, were fixed. The results showed that a rice-water ratio of 1:60 resulted in the highest comprehensive score.

[0054] The impact of rice water consumption on comprehensive scores AHP-CRITIC was used to comprehensively evaluate the index components of Atractylodes lancea at different rice-water ratios. The effects of rice-water ratios of 100:10, 100:20, and 100:30 on the comprehensive score were investigated, while other parameters, such as the processing time and temperature, were fixed. The results showed that a rice-water ratio of 100:20 achieved the highest comprehensive score.

[0055] The impact of soaking time on the overall score AHP-CRITIC was used to comprehensively evaluate the component components of Atractylodes lancea at different steaming times. The effects of steaming times of 1, 2, and 3 hours on the comprehensive score were examined, while other parameters, such as the processing time and temperature, were fixed. The results showed that a steaming time of 2 hours resulted in the highest comprehensive score. However, considering that the comprehensive scores varied significantly between steaming times, a steaming time of 1 hour was used.

[0056] Effect of processing temperature on comprehensive score AHP-CRITIC was used to comprehensively score the index components of Atractylodes lancea at different processing temperatures. The effects of processing temperatures of 170°C, 185°C, and 210°C on the comprehensive score were investigated, while other indicators, such as the processing time, were fixed. The results showed that a processing temperature of 185°C resulted in the highest comprehensive score.

[0057] The impact of preparation time on comprehensive score AHP-CRITIC was used to comprehensively score the index components of Atractylodes lancea at different processing times. The effect of processing time of 20 minutes, 30 minutes, and 40 minutes on the comprehensive score was investigated, while other indicators such as the processing temperature were fixed. The results showed that the comprehensive score was the highest when the processing time was 30 minutes.

[0058] Table 4 Comprehensive scoring results of single factor experiment (5) The indicators for response surface optimization experiments were determined based on the comprehensive scoring results. The response surface optimization experiments were conducted with the ratio of rice to water, the amount of rice to water, the processing temperature and the processing time as indicators and the comprehensive score as the response value to determine the optimal processing technology for Atractylodes lancea prepared with rice water.

[0059] Combined with the above single-factor experimental results, Design Expert 13.0 software was used according to the central composite design (CCD) principle, with the ratio of rice to water, rice water dosage, processing temperature, processing time, etc. of rice water-processed Atractylodes lancea as indicators, and the comprehensive score as the response value (Y) to conduct an optimization experiment to determine the best processing technology of Atractylodes lancea with rice water. The results are as follows Figures 4 to 9 As shown. The quadratic multivariate regression equation is Y=0.6803+0.0093A-0.027B+0.0149C+0.0065D-0.0255AB+0.0032AC+0.0266AD-0.023BC-0.0136BD-0.0272CD-0.0592A 2 -0.0497B 2 -0.0075C 2 -0.0390D 2 P<0.0001 indicates that the factors are highly significantly correlated with the response values, and P>0.05 for the lack-of-fit item indicates that the model is consistent. The comprehensive score results of the response surface are shown in Table 5.

[0060] Table 5 Response surface comprehensive scoring results The three-dimensional effect surface diagram of the processing factors and comprehensive scores was drawn using Design Expert 13.0 software. The results are shown below. Figure 3 The optimized processing technology of Atractylodes lancea with rice water is as follows: the ratio of rice to water in rice water is 1:60, the amount of rice water is 15 mL, the processing temperature is 201℃, and the processing time is 30 min.

[0061] It should be noted that when numerical ranges are mentioned in the present invention, it should be understood that both endpoints of each numerical range and any value between the two endpoints may be selected. Since the steps and methods used are the same as those in the embodiments, in order to avoid redundancy, the present invention describes preferred embodiments. Although preferred embodiments of the present invention have been described, those skilled in the art may make additional changes and modifications to these embodiments once they understand the basic inventive concepts. Therefore, the appended claims are intended to be interpreted as including the preferred embodiments and all changes and modifications that fall within the scope of the present invention.

[0062] Obviously, those skilled in the art may make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if such changes and modifications fall within the scope of the claims and their equivalents, the present invention is intended to include such changes and modifications.

Claims

1. A method for optimizing the processing technology of Atractylodes lancea prepared with rice water, characterized in that: The following steps are involved: The raw product of Atractylodes lancea is crushed to obtain Atractylodes lancea powder, and the Atractylodes lancea powder is subjected to alcohol extraction and volatile oil extraction to obtain Atractylodes lancea alcohol extract and Atractylodes lancea volatile oil; Thermal analysis was used to analyze the pyrolysis characteristics of Atractylodes lancea powder, Atractylodes lancea ethanol extract and Atractylodes lancea volatile oil, and the processing temperature range of Atractylodes lancea was preliminarily obtained based on the results of pyrolysis characteristics analysis. Based on the preliminary obtained processing temperature range of Atractylodes lancea, the content of atractylodesin, β-eudesmol and atractylodes lactone I was used as evaluation indexes. The weight coefficients of each evaluation index were determined by AHP and CRITIC respectively. The weight coefficients determined by AHP and CRITIC were combined to calculate the comprehensive weight of each evaluation index. The comprehensive score calculation formula was obtained based on the comprehensive weight results. The rice-water ratio, rice-water amount, processing temperature and processing time were used as single-factor variables, and the comprehensive scoring formula was used to comprehensively score the evaluation indicators of Atractylodes lancea under different rice-water ratios, rice-water amount, processing temperature and processing time. The indicators for response surface optimization experiment were determined based on the comprehensive scoring results. The response surface optimization experiment was conducted with the rice-water ratio, rice-water dosage, processing temperature and processing time as indicators and the comprehensive score as the response value to determine the optimal processing technology of Atractylodes lancea prepared with rice water.

2. The method for optimizing the processing technology of Scutellaria baicalensis charcoal according to claim 1, characterized in that: When determining the processing temperature range of Atractylodes lancea by pyrolysis characteristics, the temperature at which the volatile oil components of Atractylodes lancea have the maximum weight loss range is used as the starting temperature of the processing temperature range, and the end temperature of the volatile oil components of Atractylodes lancea is used as the end temperature of the processing temperature range.

3. The method for optimizing the processing technology of Scutellaria baicalensis charcoal according to claim 1, characterized in that: The preliminary results show that the processing temperature range of Atractylodes lancea is 170℃~210℃.

4. The method for optimizing the processing technology of Scutellaria baicalensis charcoal according to claim 1, characterized in that: The method for calculating the weight coefficient of AHP is as follows: according to the active ingredients in Atractylodes lancea, the main incremental components after processing and the leaching rate, each indicator is quantitatively ranked in the order of atractylodesin>β-eudesmin>>atractylodes lactone I.

5. The method for optimizing the processing technology of Scutellaria baicalensis charcoal according to claim 4, characterized in that: The order of weight coefficients determined by AHP was: atractylodesin > β-eudesmol > atractylodes lactone I.

6. The method for optimizing the processing technology of Scutellaria baicalensis charcoal according to claim 1, characterized in that: The calculation formula for the comprehensive weight is: ,in, w A is the weight of each indicator determined by AHP, w j The weights of each indicator determined by CRITIC.

7. The method for optimizing the processing technology of Scutellaria baicalensis charcoal according to claim 1, characterized in that: The response surface optimization experiment was carried out using Design Expert 13.0 software according to the central composite design principle, and the quadratic multiple regression equation Y = 0.6803 + 0.0093A - 0.027B + 0.0149C + 0.0065D - 0.0255AB + 0.0032AC + 0.0266AD - 0.023BC - 0.0136BD - 0.0272CD - 0.0592A was obtained. 2 -0.0497B 2 -0.0075C 2 -0.0390D 2 Among them, A represents the mass ratio of rice to water in rice water, B represents the amount of rice water, C represents the processing temperature, and D represents the processing time.

8. The method for optimizing the processing technology of Scutellaria baicalensis charcoal according to claim 1, characterized in that: The optimal processing technology of Atractylodes lancea with rice water is as follows: the mass ratio of rice to water is 1:60, the amount of rice water is 15 mL, the processing temperature is 201℃, and the processing time is 30 min.

9. The method for optimizing the processing technology of Scutellaria baicalensis charcoal according to claim 1, characterized in that: Thermal analysis methods include thermogravimetric analysis and differential thermogravimetric analysis.

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