Compound Chinese blister beetle capsule traditional Chinese medicine composition as well as preparation method and detection method thereof

Abstract

The invention provides a compound Chinese blister beetle capsule traditional Chinese medicine composition as well as a preparation method and a detection method thereof, and belongs to the field of traditional Chinese medicine preparation, the compound Chinese blister beetle capsule traditional Chinese medicine composition as well as the preparation method and the detection method thereof comprise the specific steps of medicinal material preparation, medicinal material cleaning, medicinal material treatment, capsule preparation, capsule sampling and chromatographic monitoring. The reasonable preparation technology is provided, the qualified rate of the prepared capsules can be increased, medicinal material cleaning work is carried out through the step 2 in the preparation process, impurities on the surfaces of medicinal materials are prevented from influencing the quality of the prepared capsules, meanwhile, in cooperation with the step 4, the capsule skin cleaning work is carried out in the capsule preparation process, and the quality of the prepared capsules is improved. Impurities generated during capsule skin preparation are prevented from being mixed into medicinal materials to influence the quality of the medicinal materials; meanwhile, the capsule detection effect is improved.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine preparation, and in particular relates to a compound mylabris capsule traditional Chinese medicine composition, a preparation method and a detection method. Background Art

[0002] Compound Mylabris Capsules are a traditional Chinese medicine containing mylabris, licorice, Ligustrum lucidum fruit, ginseng, astragalus, and Scutellaria barbata. These herbs, when combined according to Traditional Chinese Medicine principles, impart toxin-eliminating, blood-clearing, and stasis-removing properties to Compound Mylabris Capsules. Clinically, they are used as an adjunct to the treatment of some malignant tumors. However, existing Compound Mylabris Capsules traditional Chinese medicine compositions, preparation methods, and detection methods suffer from impurities on the surface of the herbs during preparation, which can affect capsule quality. Furthermore, impurities carried by the capsule's inner wall during use can affect detection results. Summary of the Invention

[0003] In order to solve the above technical problems, the present invention provides a compound mylabris capsule Chinese medicine composition, a preparation method and a detection method. By setting an impurity cleaning step in the preparation process, impurities on the surface of the medicinal materials are prevented from affecting the quality of the capsules. In addition, the capsules are cleaned during the detection process to prevent impurities in the capsules from affecting the detection results.

[0004] The traditional Chinese medicine composition of the compound mylabris capsule includes: 0.1 to 1.5 parts of mylabris, 0.5 to 3 parts of ginseng, 0.5 to 1 part of astragalus, 0.5 to 1 part of acanthopanax, 0.1 to 0.5 parts of trigonosciadium japonicum, 0.1 to 0.6 parts of Scutellaria barbata, 0.5 to 1 part of cornus officinalis, 0.1 to 0.5 parts of glossy privet fruit, 0.1 to 0.4 parts of bear bile powder, and 0.1 to 0.5 parts of liquorice.

[0005] The compound mylabris capsule Chinese medicine composition, preparation method and detection method specifically comprise the following steps:

[0006] Step 1: Prepare the medicinal materials. Before preparing the compound mylabris capsule, prepare the medicinal materials to be used in sequence.

[0007] Step 2: Clean the medicinal materials. Clean the prepared medicinal materials in turn and scrub the surface of the medicinal materials to prevent impurities on the surface of the medicinal materials from affecting the quality of the capsules.

[0008] In the second step of cleaning the medicinal materials, the first step is to clean the medicinal materials. Use a flushing tool to flush the surface of the medicinal materials.

[0009] Step 2: Scrub the medicinal materials. For medicinal materials with soil on the surface, use a soft brush to scrub them to prevent incomplete rinsing from affecting the quality of the capsules.

[0010] Step 3: Slicing. After cleaning the herbs, use slicing tools to slice the herbs that need to be decocted and cut the ground herbs into strips or slices.

[0011] Step 4: Grinding: Select appropriate grinding equipment to grind the medicinal materials that need to be ground into powder.

[0012] Step 3: Medicinal material processing, the cleaned medicinal materials need to be sliced ​​and ground into powder;

[0013] In the third step of medicinal material processing, the first step is to decoct the medicinal materials. The medicinal materials to be decocted are sliced ​​and sequentially placed into the decoction equipment for decoction.

[0014] Step 2: Mix the herbs. After boiling the herbs into a viscous liquid, add the powdered herbs to the herbs in the correct proportion and mix them.

[0015] The third step: granulation of medicinal materials. After the medicinal materials are mixed and stirred, granulation equipment is used to granulate the mixed medicinal materials;

[0016] Step 4: Capsule preparation: After processing the medicinal materials, use a weighing tool to weigh the medicinal materials and clean the capsule materials to be used;

[0017] In step 4, capsule preparation, the first step is capsule cleaning. Before capsule preparation, use cleaning tools to clean the capsule to prevent impurities from entering the capsule skin.

[0018] Step 2: Weighing the medicinal materials: Move the cleaned capsule skin and granular medicinal materials to the preparation area, use a weighing tool to weigh the medicinal materials, and put the granules into the capsule skin after weighing;

[0019] Step 5: Capsule sampling: After preparing the capsule, extract the corresponding capsule sample according to the monitoring needs;

[0020] Step 6: Chromatographic monitoring: select the appropriate monitoring tool, then use the appropriate liquid to mix the sample into the liquid required for testing, and then carry out the testing;

[0021] In step six, chromatographic monitoring, the first step: testing equipment, after taking capsule samples, select appropriate testing equipment based on the monitoring needs and the requirements of the monitoring process;

[0022] Step 2: Prepare the solution. After sampling, use a suitable liquid to prepare the solution of the extracted capsule sample and adjust the capsule to a liquid with a suitable consistency.

[0023] Step 3: Chromatographic testing. After mixing the liquid, use the selected equipment to perform the testing.

[0024] Preferably, in step 2, in the third step, when the medicinal material is sliced, the thickness is controlled to be between five millimeters and ten millimeters.

[0025] Preferably, in step 2, in the fourth step, after the medicinal materials are ground into powder, they are sieved using a mesh of 80 to 160 meshes.

[0026] Preferably, in step three, in the first step, when decocting the medicinal materials, the medicinal materials are decocted for two to six hours, and the decocting is repeated three to seven times.

[0027] Preferably, in step three, in the third step, when the medicinal material is granulated, a screening mesh with a mesh size of 50 to 80 is used for screening.

[0028] Preferably, in step six, in the third step, the cantharidin concentration is controlled within the range of 2.4611 μg / ml to 51.2720 μg / m0.9 during the detection process.

[0029] Compared with the prior art, the present invention has the following beneficial effects: the compound mylabris capsule Chinese medicine composition, preparation method, and detection method of the present invention are widely applicable to the field of Chinese medicine preparation. The present invention provides a reasonable preparation process, which can improve the qualified rate of the prepared capsules. During the preparation process, the medicinal materials are cleaned in step 2 to prevent impurities on the surface of the medicinal materials from affecting the quality of the prepared capsules. At the same time, in step 4, the capsule skin is cleaned during the capsule preparation process to reduce the possibility of impurities generated during the capsule skin preparation being mixed into the medicinal materials and affecting the quality of the medicinal materials, while also improving the capsule detection effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Figure 1 The present invention is a flow chart of a traditional Chinese medicine composition of compound mylabris capsule, a preparation method and a detection method.

[0031] Figure 2 It is a flow chart for cleaning medicinal materials.

[0032] Figure 3 It is a flow chart of medicinal material processing.

[0033] Figure 4 It is a flow chart of capsule preparation.

[0034] Figure 5 It is a flow chart of chromatography monitoring. DETAILED DESCRIPTION

[0035] The present invention will be further described below with reference to the accompanying drawings:

[0036] In the picture:

[0037] As attached Figures 1 to 5 shown

[0038] The traditional Chinese medicine composition of the compound mylabris capsule includes: 0.1 to 1.5 parts of mylabris, 0.5 to 3 parts of ginseng, 0.5 to 1 part of astragalus, 0.5 to 1 part of acanthopanax, 0.1 to 0.5 parts of trigonosciadium japonicum, 0.1 to 0.6 parts of Scutellaria barbata, 0.5 to 1 part of cornus officinalis, 0.1 to 0.5 parts of glossy privet fruit, 0.1 to 0.4 parts of bear bile powder, and 0.1 to 0.5 parts of liquorice.

[0039] The compound mylabris capsule Chinese medicine composition, preparation method and detection method specifically comprise the following steps:

[0040] S101: preparing medicinal materials. Before preparing the compound mylabris capsule, the medicinal materials to be used are prepared in sequence;

[0041] S102: Cleaning the medicinal materials: Clean the prepared medicinal materials in sequence and scrub the surfaces of the medicinal materials to prevent impurities on the surfaces of the medicinal materials from affecting the quality of the capsules;

[0042] In S102 medicinal material cleaning S201: medicinal material cleaning, use a flushing tool to flush the surface of the medicinal material;

[0043] S202: Scrubbing the medicinal materials. For medicinal materials with soil on the surface, use a soft brush to scrub them to prevent incomplete rinsing from affecting the quality of the capsules.

[0044] S203: Slicing: After the herbs are cleaned, use a slicing tool to slice the herbs that need to be decocted and cut the ground herbs into strips or slices;

[0045] S204: Grinding: Select appropriate grinding equipment to grind the medicinal materials to be ground into powder;

[0046] S103: Medicinal material processing, the cleaned medicinal materials are placed in the process of being sliced ​​and ground into powder;

[0047] In S103 medicinal material processing, S301: medicinal material decoction, the medicinal materials to be decocted are sliced ​​and sequentially placed into the decoction equipment for decoction;

[0048] S302: Mixing the medicinal materials. After the medicinal materials are boiled into a viscous liquid, the powdered medicinal materials are added to the medicinal materials in a predetermined proportion and mixed;

[0049] S303: Granulating the medicinal materials. After the medicinal materials are mixed and stirred, granulating the mixed medicinal materials using a granulating device;

[0050] S104: Capsule preparation: After the medicinal materials are processed, weigh them using a weighing tool and clean the capsule materials to be used;

[0051] In S104 capsule preparation, S401: capsule cleaning, before capsule preparation, use cleaning tools to clean the capsule to prevent impurities from being carried in the capsule skin;

[0052] S402: Weighing the medicinal materials: moving the cleaned capsule skins and granular medicinal materials to the preparation area, using a weighing tool to weigh the medicinal materials, and placing the granules into the capsule skins after weighing;

[0053] S105: Capsule sampling: After the capsules are prepared, corresponding capsule samples are extracted according to the monitoring requirements;

[0054] S106: Chromatographic monitoring: select appropriate monitoring tools, then use appropriate liquid to mix the proposed sample into the liquid required for testing, and then carry out the testing work;

[0055] In S106 Chromatographic Monitoring, S601: Testing Equipment, after taking capsule samples, select appropriate testing equipment based on monitoring needs and requirements during the monitoring process;

[0056] S602: preparing the solution. After sampling, use a suitable liquid to prepare the solution of the extracted capsule sample to adjust the capsule to a liquid with a suitable consistency;

[0057] S603: Chromatographic detection: After the liquid is prepared, use the selected equipment to perform the detection work.

[0058] Preferably, in S102, in S203, when the medicinal material is sliced, the thickness is controlled to be between five millimeters and ten millimeters.

[0059] Preferably, in S102, in S204, after the medicinal materials are ground into powder, they are screened using a mesh of 80 to 160 meshes.

[0060] Preferably, in S103, in the above-mentioned S301, when decocting the medicinal materials, the medicinal materials are decocted for two to six hours, and the decocting is repeated three to seven times.

[0061] Preferably, in S103, in said S303, when the medicinal material is granulated, a screening mesh with a mesh size of 50 to 80 is used for screening.

[0062] Preferably, in S106, in said S603, the cantharidin concentration is controlled within the range of 2.4611 μg / ml to 51.2720 μg / m0.9 during the detection process.

[0063] Specific implementation examples

[0064] Example 1: Before preparing the compound mylabris capsule, the medicinal materials to be used are prepared in sequence, and a clean water rinsing tool is used to rinse the surface of the medicinal materials. The medicinal materials with soil on the surface are scrubbed with a soft brush to prevent incomplete rinsing from affecting the quality of the capsule. After the medicinal materials are cleaned, a slicing tool is used to slice the medicinal materials to be decocted. At the same time, the ground medicinal materials are cut into strips or sheets. Suitable grinding equipment is selected to grind the medicinal materials to be ground into powder. The medicinal materials are ground into powder, and the slices of the medicinal materials to be decocted are sequentially placed in the interior of the decocting equipment for decocting. Boil for four to five hours, and repeatedly decoct for four to six times, then use a 100-120 mesh screening mesh to screen the powdered medicinal materials, and mix the medicinal liquid and powder after screening, then use granulation equipment to perform granulation, and use a cleaning tool to clean the capsule skin after granulation, after cleaning, use a weighing tool to weigh the medicinal materials, and after weighing, put the medicinal materials into the capsule skin to complete the capsule preparation, and after the capsule preparation, perform sampling, and then use a suitable liquid to prepare the solution, and after preparation, use the selected suitable equipment to perform chromatographic detection on the solution, thereby completing the preparation of the compound blister beetle capsule.

[0065] Utilizing the technical solution described in the present invention, or those skilled in the art designing similar technical solutions inspired by the technical solution of the present invention to achieve the above technical effects, all fall within the scope of protection of the present invention.

Claims

1. A Chinese medicinal composition of compound mylabris capsules, a preparation method thereof and a detection method thereof, characterized in that: The compound mylabris capsule Chinese medicinal composition comprises: 0.1 to 1.5 parts of mylabris, 0.5 to 3 parts of ginseng, 0.5 to 1 part of astragalus, 0.5 to 1 part of acanthopanax, 0.1 to 0.5 part of trifoliate lanceolate, 0.1 to 0.6 part of scutellaria barbata, 0.5 to 1 part of cornus officinalis, 0.1 to 0.5 part of glossy privet fruit, 0.1 to 0.4 part of bear bile powder and 0.1 to 0.5 part of liquorice. The compound mylabris capsule Chinese medicine composition, preparation method and detection method specifically comprise the following steps: Step 1: Prepare the medicinal materials. Before preparing the compound mylabris capsule, prepare the medicinal materials to be used in sequence. Step 2: Clean the medicinal materials. Clean the prepared medicinal materials in turn and scrub the surface of the medicinal materials to prevent impurities on the surface of the medicinal materials from affecting the quality of the capsules. In the second step of cleaning the medicinal materials, the first step is to clean the medicinal materials. Use a flushing tool to flush the surface of the medicinal materials. Step 2: Scrub the medicinal materials. For medicinal materials with soil on the surface, use a soft brush to scrub them to prevent incomplete rinsing from affecting the quality of the capsules. Step 3: Slicing. After cleaning the herbs, use slicing tools to slice the herbs that need to be decocted and cut the ground herbs into strips or slices. Step 4: Grinding: Select appropriate grinding equipment to grind the medicinal materials that need to be ground into powder. Step 3: Medicinal material processing, the cleaned medicinal materials need to be sliced ​​and ground into powder; In the third step of medicinal material processing, the first step is to decoct the medicinal materials. The medicinal materials to be decocted are sliced ​​and sequentially placed into the decoction equipment for decoction. Step 2: Mix the herbs. After boiling the herbs into a viscous liquid, add the powdered herbs to the herbs in the correct proportion and mix them. The third step: granulation of medicinal materials. After the medicinal materials are mixed and stirred, granulation equipment is used to granulate the mixed medicinal materials; Step 4: Capsule preparation: After processing the medicinal materials, use a weighing tool to weigh the medicinal materials and clean the capsule materials to be used; In step 4, capsule preparation, the first step is capsule cleaning. Before capsule preparation, use cleaning tools to clean the capsule to prevent impurities from entering the capsule skin. Step 2: Weighing the medicinal materials: Move the cleaned capsule skin and granular medicinal materials to the preparation area, use a weighing tool to weigh the medicinal materials, and put the granules into the capsule skin after weighing; Step 5: Capsule sampling: After preparing the capsule, extract the corresponding capsule sample according to the monitoring needs; Step 6: Chromatographic monitoring: select the appropriate monitoring tool, then use the appropriate liquid to mix the sample into the liquid required for testing, and then carry out the testing; In step six, chromatographic monitoring, the first step: testing equipment, after taking capsule samples, select appropriate testing equipment based on the monitoring needs and the requirements of the monitoring process; Step 2: Prepare the solution. After sampling, use a suitable liquid to prepare the solution of the extracted capsule sample and adjust the capsule to a liquid with a suitable consistency. Step 3: Chromatographic testing. After mixing the liquid, use the selected equipment to perform the testing.

2. The compound Mylabris capsule Chinese medicine composition, preparation method and detection method according to claim 1, wherein: In step 2, in the third step, when the medicinal material is sliced, the thickness is controlled to be between five millimeters and ten millimeters.

3. The compound Mylabris capsule Chinese medicine composition, preparation method and detection method according to claim 1, wherein: In step 2, in the fourth step, after the medicinal materials are ground into powder, they are screened using a mesh of 80 to 160 meshes.

4. The compound Mylabris capsule Chinese medicine composition, preparation method and detection method according to claim 1, wherein: In step three, in the first step, when decocting the medicinal materials, the medicinal materials are decocted for two to six hours, and the decocting is repeated three to seven times.

5. The compound Mylabris capsule Chinese medicine composition, preparation method and detection method according to claim 1, characterized in that: In step three, in the third step, when the medicinal materials are granulated, a screening mesh with a mesh size of 50 to 80 is used for screening.

6. The compound Mylabris capsule Chinese medicine composition, preparation method and detection method according to claim 1, characterized in that: In step six, in the third step, the cantharidin concentration is controlled within the range of 2.4611 μg / ml to 51.2720 μg / m0.9 during the detection process.

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