Cell surface friction force measuring device manufactured by three-dimensional printing

The cell surface friction measurement device manufactured through 3D printing, combined with flow impedance detection and inertial microfluidics technology, solves the problems of low detection throughput and high cost in existing technologies, and realizes high-throughput detection of cell surface friction, which is suitable for disease diagnosis and single-cell physical property research.

CN120628955APending Publication Date: 2025-09-12NANJING NORMAL UNIVERSITY
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Patent Information

Application Number
CN202510822648.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-06-19
Publication Date
2025-09-12

AI Technical Summary

Technical Problem

Existing cell surface friction measurement methods have low detection throughput and high cost, making it difficult to achieve high-throughput detection. Flow impedance detection devices are also difficult to achieve high-throughput detection of biological particle surface friction.

Method used

The cell surface friction measurement device is manufactured using 3D printing. The device consists of a flow channel layer and an electrode layer. It combines flow impedance detection technology and inertial microfluidics technology. It is produced through 3D printing technology of heterogeneous materials, and a specific flow channel and electrode structure are designed. Electric field perturbation is used to analyze cell friction.

Benefits of technology

It achieves high-throughput detection of cell surface friction, reduces detection costs, and is suitable for disease diagnosis and single-cell physical property research.

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Abstract

The invention relates to a cell surface friction force measuring device manufactured by three-dimensional printing. The cell surface friction force measuring device comprises a runner layer and an electrode layer, the flow channel layer is provided with a focusing flow channel, a detection flow channel, a friction flow channel and a waste liquid flow channel; four detection electrodes are arranged on the electrode layer, each two detection electrodes form a pair, and the detection electrodes respectively comprise an excitation electrode and an induction electrode and are respectively vertical to the detection flow channel and the friction flow channel. The focusing flow channel is in an asymmetric sine flow channel shape, and cells can be focused at a specific position of the flow channel, so that the cells pass through the detection flow channel at the same position. The friction flow channel is directly connected with the waste liquid flow channel, and the detection flow channel is obliquely connected with the friction flow channel and the waste liquid flow channel. According to the cell surface friction force measuring device manufactured through 3D printing, the indicating friction force values of different types of cells can be quantitatively obtained, and the device is designed and manufactured based on the flow impedance technology and has extremely high detection flux. Therefore, the device has an extremely high application prospect in biochemical fields such as single cell research and the like.
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