Pistacia weinmannifolia extract-containing skin care liquid perfumed soap for diabetics

Abstract

The invention provides a Pistacia weinmannifolia extract-containing skin care liquid perfumed soap for diabetics, and relates to the technical field of perfumed soap, the Pistacia weinmannifolia extract-containing skin care liquid perfumed soap for diabetics comprises Pistacia weinmannifolia essential oil, a Pistacia weinmannifolia extract, a surfactant, a synergistic skin care adjuvant, a pH regulator and deionized water, one purpose of the present invention is to provide a liquid soap composition, which comprises a Pistacia weinmannifolia extract and essential oil, and is matched with a mild soap base and an optional synergistic skin care adjuvant so as to provide a safe and effective skin care choice for diabetic patients.

Description

Technical Field

[0001] The invention belongs to the technical field of soaps, and in particular relates to a liquid soap for skin care of diabetic patients containing an extract of osmanthus fragrans. Background Art

[0002] Diabetes is a chronic metabolic disease often associated with a variety of skin complications, such as dry skin, itching, decreased elasticity, slow wound healing, and susceptibility to bacterial and fungal infections. The skin barrier function of diabetic patients is often impaired, leading to increased transepidermal water loss and increased skin fragility and sensitivity. Diabetic foot is a serious complication of diabetes. Due to neuropathy, peripheral vascular disease, and impaired immune function, the skin of the feet is extremely fragile and prone to ulcers and infections, and in severe cases, even amputation. Therefore, skin care, especially foot care, is crucial to the quality of life and health of diabetic patients.

[0003] Many common soaps currently available contain harsh chemical ingredients, such as strong surfactants (e.g., sodium lauryl sulfate (SLS) and sodium lauryl ether sulfate (SLES), artificial fragrances, and certain preservatives (e.g., parabens and formaldehyde-releasing agents). These ingredients may exacerbate dryness and sensitivity in diabetic skin, further damaging the skin barrier function. While some cleansing products are available for sensitive skin or with specific moisturizing properties, there is a lack of care soaps specifically formulated with natural botanical active ingredients to address the complex skin issues of diabetic patients (e.g., high infection risk, inflammatory propensity, oxidative stress damage, and impaired skin barrier function). In particular, for the complication of diabetic foot, cleansing products that offer excellent mildness, moisturizing properties, and antibacterial and anti-inflammatory properties are needed to help prevent infection and improve skin condition.

[0004] Pistacia weinmannifolia, a member of the genus Pistacia in the Anacardiaceae family, has a long history of use in traditional Chinese medicine, often used for anti-inflammatory, detoxification, and the treatment of boils and swelling. However, combining these beneficial properties of Pistacia weinmannifolia with a mild soap base specifically designed for diabetic patients and clearly demonstrating its application in diabetic skin and foot care has not been publicly reported. Summary of the Invention

[0005] In order to overcome the problems in the background technology, the present invention develops a diabetic skin care liquid soap containing safflower extract, aiming to solve the problem in the prior art of lacking natural plant ingredient soaps specifically for diabetic skin and foot care.

[0006] An object of the present invention is to provide a liquid soap composition comprising an extract of osmanthus fragrans, essential oils, a mild soap base and optional synergistic skin care adjuvants, in order to provide a safe and effective skin care option for diabetic patients.

[0007] Another object of the present invention is to provide a method for preparing the liquid soap composition.

[0008] Another object of the present invention is to provide the application of the liquid soap composition in diabetic foot massage care.

[0009] To achieve the above object, the present invention is implemented through the following technical solutions: The invention discloses a composition of a diabetic skin care liquid soap containing a saffron grosvenorii extract, which comprises saffron grosvenorii essential oil, saffron grosvenorii extract, a surfactant, a synergistic skin care adjuvant, a pH regulator and deionized water.

[0010] Preferably, the added amount of the Fragrant Wood essential oil is 0.5% to 3.0% of the total weight of the composition; the added amount of the Fragrant Wood extract is 0.2%-5.0% of the total weight of the composition.

[0011] Preferably, the surfactant is selected from at least one of decyl glucoside and cocamidopropyl betaine, and accounts for 7%-23% of the total weight of the composition.

[0012] Preferably, the synergistic skin care adjuvant is at least one synergistic skin care adjuvant selected from moisturizers, skin barrier repair agents, soothing agents, thickeners, preservatives, and chelating agents.

[0013] Preferably, the pH value of the composition is 4.5-6.5.

[0014] On the other hand, the present application also provides a method for preparing the liquid soap composition described in the present application, characterized in that it includes the steps of mixing the saffron essential oil, saffron extract, surfactant, synergistic skin care adjuvant and deionized water, including: S1. Preparation of aqueous phase Weigh the formulated amount of deionized water into a stirred kettle. Add the humectant and chelating agent and begin stirring. Heat the aqueous phase to 70-75°C to facilitate dissolution and dispersion of subsequent ingredients. While stirring at high speed, slowly and evenly add the thickener into the vortex of the aqueous phase. Continue stirring until the thickener is completely hydrated and dissolved, forming a uniform base liquid. S2. Preparation of surfactant phase Slightly heat the formulated surfactant to 40-50°C to reduce viscosity, making it easier to mix and subsequently add the aqueous phase. Then, while the aqueous phase is still stirring, slowly add the premixed surfactant phase to the aqueous phase. Stir gently to avoid excessive foaming until the surfactant is completely dispersed. S3. Cooling The mixture was gradually cooled while stirring to reduce the system temperature to below about 40°C; S4. Addition of active ingredients and adjuvants When the system temperature drops to an appropriate range, first add the cinnamon bark extract and cinnamon bark essential oil, stir evenly, and ensure that the cinnamon bark essential oil is well dispersed and emulsified in the surfactant system; then add the adjuvant skin barrier repair agent and soothing agent. After adding each ingredient, stir thoroughly to ensure its uniform distribution; S5. pH adjustment Use a pH meter to test the pH value of the current mixed solution. Based on the test results, slowly add the pre-prepared pH adjuster solution while continuously stirring and repeatedly testing the pH value until the pH value of the system reaches the preset target range; S6. Addition of preservatives After pH adjustment is complete, add the formulated amount of preservative or preservative system and stir thoroughly to ensure effective distribution throughout the product; S7, final mixing and settling After all ingredients are added, stir thoroughly again to ensure the uniformity of the final product; then stop stirring and let the product stand for a while to eliminate bubbles that may have been introduced during the production process; finally, the finished product is tested for quality (such as appearance, odor, pH value, viscosity, microbial limit, etc.), and can be filled after passing the test.

[0015] On the other hand, the present application also provides the use of the liquid soap composition in skin care products for diabetic patients.

[0016] Furthermore, the skin care product is used for cleaning, caring for or massaging the feet of diabetic patients: The texture and lubricity of this liquid soap also make it suitable as an auxiliary cleaning and lubricating medium for diabetic patients during foot massage. Foot massage is an important part of diabetic foot care, helping to improve local blood circulation and relieve discomfort caused by neuropathy. Beneficial effects of the present invention: 1. The liquid soap disclosed herein can be used as a daily body cleansing and care product for diabetics. Its gentle cleansing system effectively removes dirt, sweat, and excess sebum from the skin's surface while minimizing irritation and damage to the already fragile skin barrier. The formula's synergistic effect of citrus aurantium extract, moisturizers, skin barrier repair agents, and soothing agents helps improve common skin dryness, sensitivity, and itching in diabetics while cleansing. It also helps prevent various skin problems caused by a damaged skin barrier.

[0017] 2. Auxiliary medium for diabetic foot massage: Using this product during massage not only provides essential lubrication and reduces frictional damage to delicate skin, but also allows the citronella extract and other active skincare ingredients to better contact the skin during massage, potentially promoting their absorption and effectiveness. This integrated approach, combining cleansing, care, and physical massage, offers a new and more effective approach for diabetic foot care. By promoting circulation through massage, combined with the antibacterial and anti-inflammatory properties of the citronella extract and the moisturizing and soothing ingredients in the product, it can more comprehensively improve the foot skin microenvironment, playing a positive role in preventing the occurrence and progression of diabetic foot ulcers. DETAILED DESCRIPTION

[0018] In order to make the purpose, technical solutions and beneficial effects of the present invention clearer, the preferred embodiments of the present invention will be described in detail below to facilitate understanding by technicians.

[0019] 1. Soap formula composition Fragrant wood raw materials A. Fragrant wood essential oil 1. Source and plant parts: The leaves of the fragrant wood are preferred. The fragrant wood is distributed in Yunnan, Sichuan and other places in China; 2. Extraction method and key process parameters: Ultrasonic-assisted co-hydration (UWD) essential oil, crushed fragrant wood leaves and water at a ratio of 1:5-1:10, g / mL, treated in an ultrasonic device with an ultrasonic power of 200-500W and an extraction time of 20-60 minutes, and co-hydration distillation was performed to collect the essential oil at the same time.

[0020] B. Fragrant wood extract 1. Source and plant parts: The leaves of the fragrant wood are preferred. The fragrant wood is distributed in Yunnan, Sichuan and other places in China; 2. Extraction method and key process parameters: The crushed fragrant wood leaves are soaked in ethanol and water at 60∘C for 1-3 times, each time for 1-2 hours, filtered, the filtrate is combined, and the solvent is removed after concentration to obtain the extract.

[0021] The added amount of the osmanthus fragrans essential oil is 0.5%-3.0% of the total weight of the soap composition; the added amount of the osmanthus fragrans extract is 0.2%-5.0% of the total weight of the soap composition.

[0022] surfactants C. Main surfactant: decyl glucoside, added in an amount of 5.0%-15.0% of the total weight of the soap composition; D. Auxiliary surfactant: cocamidopropyl betaine, added in an amount of 2.0%-8.0% of the total weight of the soap composition.

[0023] Synergistic skin care adjuvant E. Moisturizing agent: glycerin, added in an amount of 3.0%-10.0% of the total weight of the soap composition; F. Skin barrier repair agent: Panthenol, added in an amount of 0.5% to 2.0% by weight of the total soap composition; Ceramide NP, added in an amount of 0.1%-0.5% of the total weight of the soap composition; G. Soothing agent: Allantoin, added in an amount of 0.2%-1.0% of the total weight of the soap composition; H. Thickener: xanthan gum, added in an amount of 0.1%-0.5% by weight of the total soap composition; I. Preservative: Phenoxyethanol, added in an amount of 0.5%-1.2% of the total weight of the soap composition; J. Chelating agent: disodium edetate, added in an amount of 0.05%-0.2% of the total weight of the soap composition.

[0024] 4. pH adjuster K, pH regulator: appropriate amount of citric acid Skin care adjuvants work together with the citronellol extract and a mild cleansing matrix to act on the skin of diabetic patients. For example, ceramides and panthenol are dedicated to repairing the damaged skin barrier, which makes the skin less susceptible to external irritants and can better retain internal moisture; glycerin directly replenishes and locks in moisture, relieving dryness; and allantoin can relieve itching and discomfort caused by dryness or inflammation. In such an improved skin microenvironment, the antibacterial and anti-inflammatory active ingredients of the citronellol extract can work more effectively, help maintain the condition of the skin, and provide comprehensive care benefits. The mass percentage ratios of the various components of the soap of the embodiment and comparative example are shown in Table 1.

[0025] Table 1 Liquid soap formula composition

[0026] 2. Example Example 1 Preparation of liquid soap composition Prepare the aqueous phase: Place an appropriate amount of deionized water in a stirred kettle. Add 8% by weight of glycerin and 0.1% by weight of disodium EDTA and begin stirring. Heat the aqueous phase to 70-75°C to facilitate dissolution and dispersion of subsequent ingredients. While stirring at high speed, slowly and evenly add 0.2% by weight of xanthan gum to the aqueous phase vortex. Continue stirring until the xanthan gum is fully hydrated and dissolved, forming a uniform base solution. Preparation of the surfactant phase: Gently heat 10% by weight of decyl glucoside and 5% by weight of cocamidopropyl betaine to 40-50°C to reduce viscosity and make it easier to mix and subsequently add the aqueous phase. Then, while the aqueous phase is being stirred, slowly add the premixed surfactant phase to the aqueous phase, stirring gently to avoid excessive foaming, until the surfactant is completely dispersed. S3. Cooling The mixture was gradually cooled while stirring to reduce the system temperature to below about 40°C; S4. Addition of active ingredients and adjuvants After the system temperature drops to an appropriate range, first add 3% by weight of the osmanthus extract and 1.5% by weight of the osmanthus essential oil, and stir evenly to ensure that the osmanthus essential oil is well dispersed and emulsified in the surfactant system; then add adjuvants of 1% by weight of panthenol, 0.2% by weight of ceramide NP, and 0.5% by weight of allantoin. After each ingredient is added, it is necessary to stir thoroughly to ensure its uniform distribution; S5. pH adjustment Use a pH meter to test the pH value of the current mixed solution. Based on the test results, slowly add the pre-prepared citric acid pH adjuster solution while continuing to stir and repeatedly test the pH value until the pH value of the system reaches 4.5-6.5; S6. Addition of preservatives After the pH value is adjusted, add 0.8% by weight of phenoxyethanol and stir thoroughly to ensure that it is effectively distributed throughout the product; S7, final mixing and settling After all ingredients are added, stir thoroughly again to ensure the uniformity of the final product; then stop stirring and let the product stand for a while to eliminate bubbles that may have been introduced during the production process; finally, the finished product is tested for quality (such as appearance, odor, pH value, viscosity, microbial limit, etc.), and can be filled after passing the test.

[0027] The preparation steps of Example 2 and Example 3 are the same as those of Example 1, and the formulation amounts are shown in Table 1.

[0028] 3. Control Group Comparative Example 1 The dosage of the components is shown in Table 1, which includes all other ingredients except the fragrant wood component in Example 1, namely the surfactant system and other auxiliary ingredients. The liquid soap of Comparative Example 1 is prepared according to the same steps as Example 1.

[0029] Comparative Example 2 The dosage of the components is shown in Table 1, which includes all other ingredients in Example 1 except the extract of the fragrant wood, that is, only the fragrant wood leaf extract is added to the basic formula, and the liquid soap of Comparative Example 1 is prepared according to the same steps as Example 1.

[0030] Comparative Example 3 The dosage of the components is shown in Table 1, which includes all other ingredients in Example 1 except the safflower oil component, that is, only the safflower extract is added to the basic formula, and the liquid soap of Comparative Example 1 is prepared according to the same steps as Example 1.

[0031] Comparative Example 4 The dosage of the components is shown in Table 1, which includes all the ingredients of Example 1. The amount of the fragrant wood essential oil component added is lower than that of Example 2. The liquid soap of Comparative Example 1 is prepared according to the same steps as Example 1.

[0032] Comparative Example 5 The dosage of the components is shown in Table 1, which includes all the ingredients of Example 1. The amount of the fragrant wood essential oil component added is higher than that of Example 3. The liquid soap of Comparative Example 1 is prepared according to the same steps as Example 1.

[0033] 4. The efficacy indexes and physical and chemical properties of the above groups were tested, as shown in Table 2.

[0034] Table 2 Liquid soap efficacy index and physical and chemical properties test table

[0035] Test method and standard description: 1. Appearance and properties Purpose of Test: To evaluate basic physical properties of liquid soaps such as color, uniformity, odor, and texture.

[0036] Test Method: Sensory testing involves visually inspecting samples for color, clarity, uniformity, and the presence of particulate matter or delamination. Smell and touch are also used to assess odor and texture. The standard requires the product to be a homogeneous fluid with a characteristic mild odor (the fragrant wood component imparts a natural herbal aroma) and be free of visible impurities.

[0037] 2. pH value Purpose of the test: To ensure that the pH value of the product is within a range that is friendly to the skin, especially suitable for the sensitive skin of diabetic patients.

[0038] Test method: Based on QB / T 2485-2008 standard, pH meter is used for determination. Usually, a 1% aqueous solution of the product is taken and measured using a calibrated pH meter at a standard temperature (e.g. 25°C).

[0039] Healthy skin has a slightly acidic pH (approximately 4.7-5.75). This acidic outer layer is crucial for maintaining the skin's barrier function and inhibiting the growth of harmful microorganisms. Diabetics often experience impaired skin barrier function, making it more sensitive to pH changes. Highly alkaline cleansing products can further damage the skin barrier, exacerbating dryness and irritation, and increasing the risk of infection. Therefore, the present invention controls the pH within the slightly acidic range of 4.5-6.5, helping to protect the skin barrier and reduce irritation.

[0040] 3. Viscosity Purpose of test: To ensure that the product has suitable fluidity, is easy to use, and contributes to product stability.

[0041] Test method: According to QB / T 2485-2008 standard, use a rotational viscometer to measure at a specified temperature (such as 25∘C) and an appropriate rotor / speed combination. The result is in mPa·s or cP.

[0042] 4. Cleanliness Purpose of Test: To evaluate the ability of liquid soap to remove dirt and sebum from the skin surface.

[0043] Test Method: Artificial sebum removal method. A standard artificial sebum mixture is evenly applied to a standard soiled cloth. The cloth is then cleaned with the test liquid soap solution under controlled conditions: product concentration, water temperature, wash time, and mechanical agitation intensity. Cleansing effectiveness is assessed by measuring the amount of sebum remaining on the substrate after washing and analyzing the sebum content in the eluate. Results are expressed as sebum removal percentage (%).

[0044] 5. Lubricity and skin feel Purpose of the test: To evaluate the sensory properties of the product during and after use, especially its lubricity.

[0045] Testing Method: A sensory evaluation method was used. Twenty evaluators were recruited to apply a standardized amount of each sample to designated skin areas, such as the inner forearm. Evaluators rated a series of sensory attributes using a pre-defined scale (1-7), including ease of application, lubricity during application (slipperiness), post-rinse skin feel (tightness), and after application (10-15 minutes).

[0046] Simulation / expected results: (1-7 points, 7 is the best) A higher lubricity (e.g., 6 / 7) produces moderately fine foam that is easy to rinse off. After washing, the skin feels smooth and soft without any noticeable tightness.

[0047] 6. In vitro antibacterial activity Purpose of test: To evaluate the product's ability to inhibit or kill common skin pathogens.

[0048] Test method: Agar diffusion method (inhibition zone test) should be used. Test bacteria should include Staphylococcus aureus, Escherichia coli, and Candida albicans.

[0049] Inhibition zone method: punch a hole or place a filter paper soaked with the sample on the agar plate inoculated with the test strain, and measure the diameter of the transparent inhibition zone around the hole or filter paper after incubation.

[0050] 7. In vitro antioxidant activity Purpose of the test: To determine the product's ability to scavenge free radicals, which is important for protecting the skin from oxidative stress.

[0051] Test Method: DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging test. The product is mixed with a methanol or ethanol solution of DPPH. After the DPPH free radical is reduced, the solution color changes from purple to yellow. The change in absorbance is measured by spectrophotometry at a specific wavelength (approximately 517 nm).

[0052] 8. In vitro anti-inflammatory activity Purpose of Test: To evaluate the product's ability to reduce inflammation, which is critical for irritated or sensitive skin in diabetic patients.

[0053] Testing Method: This test utilizes an LPS (lipopolysaccharide)-induced macrophage inflammation model. Macrophages (e.g., the RAW264.7 cell line) are stimulated with LPS to induce an inflammatory response. The product to be tested or its extract is then added and incubated. Levels of inflammatory cytokines (e.g., tumor necrosis factor-α and interleukin-6) in the cell culture supernatant are measured using methods such as ELISA to evaluate the product's inhibitory effect on these inflammatory mediators.

[0054] 9. Skin irritation assessment Purpose of test: To assess the potential of a product to cause skin irritation. This test is critical for products suitable for diabetic patients.

[0055] Testing Method: A repeated open-smear test was conducted on 20 healthy volunteers, including some with self-reported skin sensitivity and those with diabetes. A small amount of product (2 mL) was applied twice daily to a designated skin area (5 cm x 5 cm), such as the inner forearm, for 7 consecutive days. Skin reactions (erythema, edema, papules, pruritus, dryness, etc.) were observed and recorded daily by a qualified professional and scored. Scoring scale: For example, 0 = no reaction, 1 = mild, 2 = moderate, and 3 = severe. A cumulative irritation score was calculated.

[0056] 5. Data Analysis Analysis of the physicochemical property data in Table 2 shows that the pH values ​​of all formulas are controlled within the skin-friendly range of 4.5-6.5. The cleansing data show that the selected mild surfactant system can effectively remove dirt and lay the foundation for the subsequent mildness evaluation.

[0057] By comparing Examples 1-3 containing the fragrant wood component with Comparative Example 1, which does not contain the fragrant wood component, it can be seen that the fragrant wood component plays a key role in antibacterial, antioxidant, and anti-inflammatory effects. By comparing Example 1, Comparative Example 4, and Comparative Example 5, 3.0% essential oil concentration ensures efficacy while also taking into account the mildness and economy of the product.

[0058] Based on the test results, the liquid soap containing the extract of the present invention exhibits multiple advantages, making it particularly suitable for skin care of diabetic patients: Mildness and Safety: The pH value is controlled within the skin-friendly range (5.2-5.8), with extremely low irritation (average cumulative irritation score ≤ 0.3). This is crucial for diabetic skin with impaired barrier function and prone to sensitivity. It also provides excellent lubricity and post-wash feel (lubricity score 5.8-6.5 in the example), without any tightness, making it suitable for daily cleansing and as a patented foot massage aid.

[0059] Antibacterial: The fragrant wood components give the product significant in vitro antibacterial activity, which helps inhibit the growth of harmful microorganisms on the skin surface and reduce the risk of skin infections in diabetic patients.

[0060] Antioxidant: The product has good free radical scavenging ability, which helps to resist the damage to the skin caused by oxidative stress.

[0061] Anti-inflammatory and soothing: The product can effectively inhibit the production of inflammatory factors and show good soothing and antipruritic effects, which helps to relieve the common inflammation and itching symptoms of diabetic skin.

[0062] These properties work together to enable the product of the present invention to provide a comprehensive skin care solution for diabetic patients, which not only cleanses the skin but also helps improve their unique skin problems.

[0063] Finally, it should be noted that the above preferred embodiments are only used to illustrate the technical solutions of the present invention and are not limiting. Although the present invention has been described in detail through the above preferred embodiments, those skilled in the art should understand that various changes can be made in form and details without departing from the scope defined by the claims of the present invention.

Claims

1. A composition of a diabetic skin care liquid soap containing an extract of the woody plant, characterized in that: Contains citronellol essential oil, citronellol extract, surfactants, synergistic skin care adjuvants, pH adjusters and deionized water.

2. The composition according to claim 1, characterized in that The added amount of the Fragrant Wood essential oil is 0.5% to 3.0% of the total weight of the composition; the added amount of the Fragrant Wood extract is 0.2%-5.0% of the total weight of the composition.

3. The composition according to claim 1, characterized in that The surfactant is selected from at least one of decyl glucoside and cocamidopropyl betaine.

4. The composition according to claim 1, characterized in that The synergistic skin care adjuvant is selected from at least one of moisturizers, skin barrier repair agents, soothing agents, thickeners, preservatives, and chelating agents.

5. The composition according to claim 1, characterized in that The pH value of the composition is 4.5-6.

5.

6. A method for preparing the liquid soap composition according to any one of claims 1 to 5, characterized in that: The method comprises the steps of mixing the saffron wood essential oil, the saffron wood extract, the one or more surfactants, an optional synergistic skin care adjuvant and deionized water.

7. Use of the liquid soap composition according to claim 1 in skin care products for diabetic patients.

8. The use according to claim 7, wherein the skin care product is used for cleaning, caring for or massaging the feet of diabetic patients.

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