Nanometer ion film patch and preparation method thereof

Abstract

The invention discloses a nano ion film patch and a preparation method thereof, the nano ion film patch is composed of a component A and a component B. The component A is composed of, by weight, 20-40 parts of nano ceramic particles, 10-20 parts of a silane coupling agent, 5-7 parts of zirconium phosphate powder, 0.8-1.2 parts of natural copper powder and 30-50 parts of acetylene black powder; and the component B comprises medical adhesive cloth and release paper. Far infrared rays released by the metal ceramic particles can be deeply conducted into human bodies by using excellent conduction performance of acetylene black, and can generate resonance and warming effects with nerve cells, so that local capillaries are effectively and rapidly expanded, blood vessel blockage is broken through, blood circulation is promoted, and the oxygen content in blood is increased; the traditional Chinese medicine composition achieves the effects of improving and treating hysteromyoma caused by qi stagnation, blood stasis and congealing cold and inhibiting recurrence of hysteromyoma, can be used for a long time, and has small side effects.

Description

Field of the Invention

[0001] The invention relates to a nano ion film patch and a preparation method thereof, belonging to the technical field of medical patch products. Background Art

[0002] Uterine fibroids are the most common benign tumors of the female genitalia, affecting approximately 25% of women of childbearing age. Consequently, tens of millions of women worldwide suffer from uterine fibroids. Traditional Chinese Medicine (TCM) considers uterine fibroids to be caused by organ dysfunction, qi stagnation, blood stasis, cold congestion, phlegm obstruction, damp-heat, and insufficient vital energy, and classifies them as stone masses. The most common clinical symptoms include uterine bleeding, lower abdominal pain and dysmenorrhea, pressure, increased vaginal discharge, anemia, and even infertility. These conditions can severely impact women's health and daily life, and if left untreated, they can potentially transform into malignant tumors.

[0003] Currently, the main treatments for uterine fibroids are surgery and medication. Surgical treatment is relatively complex and requires a comprehensive consideration of the patient's overall condition. Medication is divided into traditional Chinese medicine (TCM) and Western medicine. However, TCM has its drawbacks, requiring prompt treatment and a long course of treatment. Western medicine, while effective quickly, also has significant side effects, including nausea and vomiting, increased menstrual flow, edema, allergies, and dizziness. Uterine fibroids are also prone to recurrence, often even after surgery.

[0004] The nano-ion film patch prepared by the present invention is applied externally to the affected area directly, and utilizes the excellent conductive properties of acetylene black to conduct the far infrared rays released by the metal ceramic particles deeply into the human body, thereby improving and treating uterine fibroids caused by qi stagnation, blood stasis, and cold coagulation, and inhibiting the recurrence of uterine fibroids. It can be used for a long time with little side effects. Summary of the Invention

[0005] The technical problem to be solved by the present invention is to provide a nano-ion film patch and a preparation method thereof. The present invention utilizes the excellent conductive properties of acetylene black to conduct the far infrared rays released by metal ceramic particles deeply into the human body, producing resonance and thermal effects with nerve cells, effectively causing the rapid expansion of local capillaries, unblocking blood vessel blockages, promoting blood circulation, and increasing the oxygen content in the blood, thereby improving and treating uterine fibroids caused by qi stagnation, blood stasis, and cold coagulation, and inhibiting the recurrence of uterine fibroids. The patch can be used for a long time with minimal side effects.

[0006] In order to solve the above technical problems, the present invention adopts the following technical solutions:

[0007] A nano-ion film patch consists of component A and component B, wherein component A, calculated by weight, consists of 20-40 parts of nano-ceramic particles, 10-20 parts of silane coupling agent, 5-7 parts of zirconium phosphate powder, 0.8-1.2 parts of natural copper powder, and 30-50 parts of acetylene black powder; component B includes medical viscose cloth and release paper.

[0008] The aforementioned nano-ion film patch consists of component A and component B, wherein component A, calculated by weight, consists of 30 parts of nano-ceramic particles, 15 parts of silane coupling agent, 6 parts of zirconium phosphate powder, 1 part of natural copper powder, and 40 parts of acetylene black powder; component B includes medical viscose tape and release paper.

[0009] The nano ceramic particles are powders with a particle size of 50-100 μm.

[0010] The particle size of the zirconium phosphate is 100-200 μm.

[0011] The particle size of the natural copper powder is 100-200 μm.

[0012] The particle size of the aforementioned acetylene black powder is 50-100 μm.

[0013] The aforementioned silane coupling agent is γ-aminopropyltriethoxysilane.

[0014] The preparation method of the aforementioned nano-ion film patch comprises the following steps:

[0015] (1) Adding nano-ceramic particles to zirconium phosphate powder and natural copper powder, mixing and stirring for 30-60 minutes at a stirring rate of 1000-2000 r / min to obtain coupled metal ceramic particles, which are set aside;

[0016] (2) adding acetylene black powder to the coupled metal ceramic particles, mixing and stirring for 25-35 minutes at a stirring rate of 1000-2000 r / min to obtain a coupled metal ceramic particle composite material for later use;

[0017] (3) adding 95% ethanol to a silane coupling agent, stirring and hydrolyzing for 4-6 minutes to obtain a 2-3% silane coupling agent solution, adding the coupled metal ceramic particle composite material, stirring evenly, and then placing it in a microwave oven and treating it at a microwave power of 80-120 W for 2-3 minutes to obtain a nano-ion film substrate;

[0018] (4) The medical viscose cloth is used as the lower layer, the middle layer is the nano-ion film, and the nano-ion film substrate is coated in the middle of the medical viscose cloth. The substrate amount is 500-1000 g / m 2 , and the upper layer is covered with release paper to obtain the nano ion film patch.

[0019] Specifically, the preparation method of the aforementioned nano-ion film patch includes the following steps:

[0020] (1) Adding nano-ceramic particles to zirconium phosphate powder and natural copper powder, mixing and stirring for 45 minutes at a stirring rate of 1500 r / min to obtain coupled metal ceramic particles, which are set aside;

[0021] (2) adding acetylene black powder to the coupled metal ceramic particles, mixing and stirring for 30 minutes at a stirring rate of 1500 r / min to obtain a coupled metal ceramic particle composite material for later use;

[0022] (3) Add 95% ethanol to the silane coupling agent, stir and hydrolyze for 5 minutes to obtain a 2.5% silane coupling agent solution, add the coupled metal ceramic particle composite material, stir evenly, and then place it in a microwave oven and treat it at a microwave power of 100 W for 2.5 minutes to obtain a nano-ion film substrate;

[0023] (4) The medical viscose cloth is used as the lower layer, the middle layer is the nano-ion film, and the nano-ion film substrate is coated in the middle of the medical viscose cloth. The substrate amount is 500-1000 g / m 2 The upper layer is covered with release paper to effectively isolate the nano-ion film patch.

[0024] The aforementioned nano-ion film patch is used for treating and inhibiting uterine fibroids. The aforementioned nano-ion film patch can be used to treat uterine fibroids and inhibit the recurrence of uterine fibroids.

[0025] Compared with the prior art, the present invention has the following beneficial effects:

[0026] 1. The nano-ion film patch prepared by the present invention couples ceramic particles with zirconium phosphate and natural copper, so that a layer of metal particles is attached to the outer layer of the ceramic particles, forming a spatial layered mesoporous structure. This prevents the aggregation of ceramic particles and allows the interlayer mesopores to adsorb acetylene black to form a metal ceramic particle-acetylene black nanocomposite material. Utilizing the excellent conductive properties of acetylene black, the far infrared rays released by the ceramic particles can be deeply transmitted into the human body, resonating with nerve cells and generating a warming effect, effectively causing the rapid expansion of local capillaries, unblocking blood vessels, promoting blood circulation, and increasing the oxygen content in the blood.

[0027] 2. Moreover, the biostability of acetylene black is utilized to fully improve the bioavailability of ceramic particles, so that ceramic particles and natural copper form a medium space, which promotes blood circulation, helps to clear blocked blood vessels, enhances the effect of promoting blood circulation and removing blood stasis, and strengthens the efficacy of treating blood stasis.

[0028] 3. Zirconium phosphate is also a nano-metal ion antibacterial agent, which can prevent skin infection caused by long-term use.

[0029] 4. γ-aminopropyltriethoxysilane is coupled to the metal ceramic particles-acetylene black nanocomposite material to form a sticky base material while improving the dispersibility of the metal ceramic particles-acetylene black nanocomposite material. Ultimately, the nano-ion film can release far infrared rays with a wavelength of 11±1 microns, thereby improving and treating uterine fibroids caused by qi stagnation, blood stasis, and cold coagulation, and inhibiting the recurrence of uterine fibroids. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Figure 1 is the E2 concentration of uterine fibroid model rats in each group;

[0031] Figure 2 is the P concentration of uterine fibroid model rats in each group. DETAILED DESCRIPTION

[0032] The present invention will be further described below in conjunction with the accompanying drawings and specific examples. It should be understood that these examples are intended to illustrate the present invention and are not intended to limit the scope of the invention. The operating methods in the following examples where no specific conditions are specified are generally performed under conventional conditions or as recommended by the manufacturer.

[0033] Example 1

[0034] Raw materials preparation:

[0035] (1) ball-milling ceramic particles into fine powder with a particle size range of 50-100 μm to obtain nano-ceramic particles;

[0036] (2) ball-milling zirconium phosphate into a fine powder with a particle size range of 100-200 μm to obtain zirconium phosphate powder;

[0037] (3) taking natural copper and grinding it into a fine powder with a particle size range of 100-200 μm using a ball mill to obtain natural copper powder;

[0038] (4) Take acetylene black and grind it into acetylene black powder with a particle size of 100-200 μm using a ball mill.

[0039] The raw materials used in the following examples are the nano-ceramic particles, zirconium phosphate powder, natural copper powder and acetylene black powder prepared in Example 1.

[0040] Example 2

[0041] Formula of Nano Ion Film Patch:

[0042] It consists of 30 parts of nano-ceramic particles, 15 parts of γ-aminopropyltriethoxysilane, 6 parts of zirconium phosphate powder, 1 part of natural copper powder, and 40 parts of acetylene black powder; component B includes medical viscose cloth and release paper.

[0043] Preparation of nano-ion film patch:

[0044] (1) Adding nano-ceramic particles to zirconium phosphate and natural copper powder and stirring for 45 minutes at a stirring rate of 1500 r / min to obtain coupled metal ceramic particles for later use;

[0045] (2) adding acetylene black powder to the coupled metal ceramic particles, mixing and stirring for 30 minutes at a stirring rate of 1500 r / min to obtain a coupled metal ceramic particle composite material for later use;

[0046] (3) Add 95% ethanol to the silane coupling agent, stir and hydrolyze for 5 minutes to obtain a 2.5% silane coupling agent solution, add the coupled metal ceramic particle composite material, stir evenly, and then place it in a microwave oven and treat it at a microwave power of 100 W for 2.5 minutes to obtain a nano-ion film substrate;

[0047] (4) Coat the nano-ion film substrate in the middle of the medical viscose cloth, with a substrate weight of 800 g / m 2 , both the top and bottom are covered with release paper to effectively isolate the nano-ion film patch.

[0048] Example 3

[0049] Formula of Nano Ion Film Patch:

[0050] It consists of 30 parts of nano-ceramic particles, 15 parts of γ-aminopropyltriethoxysilane, 6 parts of zirconium phosphate powder, 1 part of natural copper powder, and 40 parts of acetylene black powder; component B includes medical viscose cloth and release paper.

[0051] Preparation of nano-ion film patch:

[0052] (1) Adding nano-ceramic particles to zirconium phosphate powder and natural copper powder, mixing and stirring for 60 minutes at a stirring rate of 2000 r / min to obtain coupled metal ceramic particles, which are set aside;

[0053] (2) Adding acetylene black powder to the coupled metal ceramic particles, mixing and stirring for 25 minutes at a stirring rate of 2000 r / min to obtain a coupled metal ceramic particle composite material for later use;

[0054] (3) Add 95% ethanol to the silane coupling agent and stir for 6 minutes to hydrolyze to obtain a 2% γ-aminopropyltriethoxysilane solution, add the coupled metal ceramic particle composite material, stir evenly, and then place it in a microwave oven and treat it at a microwave power of 80 W for 2 minutes to obtain a nano-ion film substrate;

[0055] (4) The medical viscose cloth is used as the lower layer, the middle layer is the nano-ion film, and the nano-ion film substrate is coated in the middle of the medical viscose cloth. The substrate amount is 1000 g / m 2 , and the upper layer is covered with release paper to obtain the nano ion film patch.

[0056] Example 4

[0057] Formula of Nano Ion Film Patch:

[0058] It consists of 30 parts of nano-ceramic particles, 15 parts of γ-aminopropyltriethoxysilane, 6 parts of zirconium phosphate powder, 1 part of natural copper powder, and 40 parts of acetylene black powder; component B includes medical viscose cloth and release paper.

[0059] Preparation of nano-ion film patch:

[0060] (1) Adding nano-ceramic particles to zirconium phosphate powder and natural copper powder, mixing and stirring for 30 minutes at a stirring rate of 1000 r / min to obtain coupled metal ceramic particles, which are set aside;

[0061] (2) Adding acetylene black powder to the coupled metal ceramic particles, mixing and stirring for 35 minutes at a stirring rate of 1000 r / min to obtain a coupled metal ceramic particle composite material for later use;

[0062] (3) Add 95% ethanol to the silane coupling agent and stir for 4 minutes to hydrolyze to obtain a 3% γ-aminopropyltriethoxysilane solution, add the coupled metal ceramic particle composite material, stir evenly, and then place it in a microwave oven and treat it at a microwave power of 120 W for 3 minutes to obtain a nano-ion film substrate;

[0063] (4) The medical viscose cloth is used as the lower layer, the middle layer is the nano-ion film, and the nano-ion film substrate is coated in the middle of the medical viscose cloth. The substrate amount is 500 g / m 2 , and the upper layer is covered with release paper to obtain the nano ion film patch.

[0064] Example 5

[0065] Formula of Nano Ion Film Patch:

[0066] It consists of 20 parts of nano-ceramic particles, 10 parts of γ-aminopropyltriethoxysilane, 7 parts of zirconium phosphate powder, 0.8 parts of natural copper powder, and 30 parts of acetylene black powder; component B includes medical viscose cloth and release paper.

[0067] Preparation of nano-ion film patch:

[0068] (1) Adding nano-ceramic particles to zirconium phosphate powder and natural copper powder, mixing and stirring for 40 minutes at a stirring rate of 1500 r / min to obtain coupled metal ceramic particles, which are set aside;

[0069] (2) Adding acetylene black powder to the coupled metal ceramic particles, mixing and stirring for 32 minutes at a stirring rate of 1500 r / min to obtain a coupled metal ceramic particle composite material for later use;

[0070] (3) Add 95% ethanol to the silane coupling agent and stir for 5 minutes to hydrolyze to obtain a 2% γ-aminopropyltriethoxysilane solution, add the coupled metal ceramic particle composite material, stir evenly, and then place it in a microwave oven and treat it at a microwave power of 90 W for 2.5 minutes to obtain a nano-ion film substrate;

[0071] (4) The medical viscose cloth is used as the lower layer, the middle layer is the nano-ion film, and the nano-ion film substrate is coated in the middle of the medical viscose cloth. The substrate weight is 600 g / m 2 , and the upper layer is covered with release paper to obtain the nano ion film patch.

[0072] Example 6

[0073] Formula of Nano Ion Film Patch:

[0074] It consists of 30 parts of nano-ceramic particles, 20 parts of γ-aminopropyltriethoxysilane, 5 parts of zirconium phosphate powder, 1.2 parts of natural copper powder, and 50 parts of acetylene black powder; component B includes medical viscose cloth and release paper.

[0075] Preparation of nano-ion film patch:

[0076] (1) Adding nano-ceramic particles to zirconium phosphate powder and natural copper powder, mixing and stirring for 50 minutes at a stirring rate of 1500 r / min to obtain coupled metal ceramic particles, which are set aside;

[0077] (2) Adding acetylene black powder to the coupled metal ceramic particles, mixing and stirring for 28 minutes at a stirring rate of 1500 r / min to obtain a coupled metal ceramic particle composite material for later use;

[0078] (3) Add 95% ethanol to the silane coupling agent and stir for 4 minutes to hydrolyze to obtain a 2.5% γ-aminopropyltriethoxysilane solution, add the coupled metal ceramic particle composite material, stir evenly, and then place it in a microwave oven and treat it at a microwave power of 110 W for 3 minutes to obtain a nano-ion film substrate;

[0079] (4) The medical viscose cloth is used as the lower layer, the middle layer is the nano-ion film, and the nano-ion film substrate is coated in the middle of the medical viscose cloth. The substrate weight is 800 g / m 2 , and the upper layer is covered with release paper to obtain the nano ion film patch.

[0080] Comparative Example 1

[0081] Formula of Nano Ion Film Patch:

[0082] It consists of 30 parts of nano-ceramic particles, 15 parts of γ-aminopropyltriethoxysilane, 1 part of natural copper powder, and 40 parts of acetylene black powder; component B includes medical viscose cloth and release paper.

[0083] Preparation of nano-ion film patch:

[0084] (1) Adding nano-ceramic particles to natural copper powder and mixing them for 60 minutes at a stirring rate of 2000 r / min to obtain coupled metal ceramic particles for later use;

[0085] (2) Adding acetylene black powder to the coupled metal ceramic particles, mixing and stirring for 25 minutes at a stirring rate of 2000 r / min to obtain a coupled metal ceramic particle composite material for later use;

[0086] (3) Add 95% ethanol to the silane coupling agent and stir for 6 minutes to hydrolyze to obtain a 2% γ-aminopropyltriethoxysilane solution, add the coupled metal ceramic particle composite material, stir evenly, and then place it in a microwave oven and treat it at a microwave power of 80 W for 2 minutes to obtain a nano-ion film substrate;

[0087] (4) The medical viscose cloth is used as the lower layer, the middle layer is the nano-ion film, the nano-ion film substrate is coated in the middle of the medical viscose cloth, the substrate amount is 1000 g / m2, and the upper layer is covered with release paper to obtain the nano-ion film patch.

[0088] Comparative Example 2

[0089] Formula of Nano Ion Film Patch:

[0090] It consists of 30 parts of nano-ceramic particles, 15 parts of γ-aminopropyltriethoxysilane, 6 parts of zirconium phosphate powder, and 40 parts of acetylene black powder; component B includes medical viscose cloth and release paper.

[0091] Preparation of nano-ion film patch:

[0092] (1) Adding nano-ceramic particles to zirconium phosphate and stirring for 45 minutes at a stirring rate of 1500 r / min to obtain coupled metal ceramic particles for later use;

[0093] (2) adding acetylene black powder to the coupled metal ceramic particles, mixing and stirring for 30 minutes at a stirring rate of 1500 r / min to obtain a coupled metal ceramic particle composite material for later use;

[0094] (3) Add 95% ethanol to the silane coupling agent, stir and hydrolyze for 5 minutes to obtain a 2.5% silane coupling agent solution, add the coupled metal ceramic particle composite material, stir evenly, and then place it in a microwave oven and treat it at a microwave power of 100 W for 2.5 minutes to obtain a nano-ion film substrate;

[0095] (4) Coat the nano-ion film substrate in the middle of the medical viscose cloth, with a substrate weight of 800 g / m 2 , both the top and bottom are covered with release paper to effectively isolate the nano-ion film patch.

[0096] Comparative Example 3

[0097] Formula of Nano Ion Film Patch:

[0098] It consists of 30 parts of nano-ceramic particles, 15 parts of γ-aminopropyltriethoxysilane, 6 parts of zirconium phosphate, and 1 part of natural copper powder; component B includes medical viscose cloth and release paper.

[0099] Preparation of nano-ion film patch:

[0100] (1) Adding nano-ceramic particles to zirconium phosphate and natural copper powder and stirring for 45 minutes at a stirring rate of 1500 r / min to obtain coupled metal ceramic particles for later use;

[0101] (2) adding 95% ethanol to a silane coupling agent, stirring and hydrolyzing for 5 minutes to obtain a 2.5% silane coupling agent solution, adding coupling metal ceramic particles, stirring evenly, and then placing the solution in a microwave oven and treating it at a microwave power of 100 W for 2.5 minutes to obtain a nano-ion film substrate;

[0102] (4) The nano-ion film substrate is coated in the middle of the medical viscose cloth, with a substrate weight of 800 g / m2, and is covered with release paper on the top and bottom to effectively isolate the nano-ion film patch.

[0103] Experimental Example 1: Animal Experiment

[0104] 1. Experimental Animal Grouping and Modeling

[0105] 60 female non-pregnant SD rats of one week old were taken and adaptively raised for 7 days and then randomly divided into 6 groups, including: blank control group, model control group, medication group 1 (Example 1), medication group 2 (Comparative Example 1), medication group 3 (Comparative Example 2), medication group 4 (Comparative Example 3). Except the blank group, the remaining groups were intraperitoneally injected with estradiol benzoate 0.5mg / Kg once a day for 4 consecutive weeks, and then injected with progesterone injection 4mg / kg once a week for 4 consecutive weeks. The blank control group was intraperitoneally injected with 1mL / 100g normal saline once a day for 8 consecutive weeks. After the modeling was completed, one rat was randomly selected from each group to test the uterine fibroid model indicators to determine whether the model was successful.

[0106] 2. Drug administration in rats with uterine fibroids model

[0107] After modeling, rats in each group were given drug intervention: the blank control group and the model control group were gavaged with the same volume of normal saline every day; sample groups 1-4 were patched with nano-ion film on the uterus in the abdomen for 4 hours every day; the drugs were used continuously for 5 weeks.

[0108] 3. Collection and Treatment of Experimental Animals

[0109] 3.1 Serum sampling

[0110] After the last administration, blood was collected from the abdominal aorta of rats in each group, and the serum was centrifuged (3500 r / min, 10 min). The serum was then collected to measure the estradiol (E2) and progesterone (P) levels.

[0111] 3.2 Uterine Adoption

[0112] After the experiment, the animals were killed by cervical dislocation, and the living uteri of the rats were isolated. The morphology and color of the uteri of each group of rats were observed with the naked eye and photographed. The rat uteri were weighed and the uterine coefficient was calculated. The maximum diameter of the uterine body and the lengths of the left and right uterine horns of the rats were measured with a vernier caliper and recorded. The rats' solid organs were observed with the naked eye for visible pathological changes. The uteri were removed, washed with physiological saline, and weighed to calculate the uterine coefficient / % = (wet weight of uterus / rat body weight) × 100.

[0113] 4. Results and Analysis

[0114] 4.1 Body weight changes of rats in each group

[0115] During the modeling period, the body weight of rats in each modeling group increased slowly compared with that in the normal group, and at the 4th week, the body weight of rats in each group progressively decreased, and the growth trend was not obvious; starting from the 8th week of drug treatment, the body weight of rats in each drug-treated group gradually increased, and showed an upward trend compared with the body weight of rats in the blank control group.

[0116] 4.2 Effect of rat uterine organ coefficient and weight

[0117] Compared with the blank control group, the uterine organ coefficient of the model control group was significantly different (P < 0.01), indicating that the model was successfully established. The uterine organ coefficient of each medication group was reduced to varying degrees compared with the model group, and the uterine organ coefficient of each medication group was significantly different from that of the model control group (P < 0.05). The details of the reduction in uterine weight in medication group 1 compared with the model control group were clear. Compared with the blank group, the uterine organ coefficient of each group was significantly different from that of the model group (P < 0.05). This shows that the nano-ion film patch of the present invention can reduce the uterine organ coefficient, and medication group 1 is better than medication groups 2-4, as shown in Table 1.

[0118] Table 1 Effects on uterine organ coefficients in rats with uterine fibroids model (±s)

[0119] Grouping Uterine coefficient Uterine weight Blank control group 0.258±0.022 0.89±0.15 Model control group <![CDATA[0.495±0.046 Δ ]]> <![CDATA[1.41±0.68 Δ ]]> Sample Group 1 0.271±0.025* 0.97±0.15 Sample Group 2 0.347±0.032** 1.17±0.15 Sample Group 3 0.353±0.018** 1.15±0.15 Sample Group 4 0.376±0.035** 1.29±0.15

[0120] Δ =” represents the comparison between the model group and the blank group, P < 0.05; * represents the comparison between the medication group and the model group, P < 0.01; ** represents the comparison between the medication group and the model group, P < 0.05.

[0121] 4.3 Detection of hormone levels in rat serum

[0122] Compared with the blank group, the E2 concentration and P concentration of the model group were significantly different (P < 0.01), indicating that the experimental animal model was successfully established. Compared with the model control group, the E2 concentration and P concentration of each medication group were reduced to varying degrees, and there were significant differences (P < 0.01). This shows that the nano-ion film patch of the present invention can reduce the E2 concentration and P concentration, and medication group 1 is better than medication groups 2-4. The results are shown in Table 2. Figure 1 、 Figure 2 .

[0123] Table 2 Effects on E2 and P concentrations in rats with uterine fibroids (±s) (pg / mL)

[0124] Grouping E2 P Blank control group 159±0.028 4.521±0.115 Model control group <![CDATA[804±0.057 Δ ]]> <![CDATA[4.914±0.128 Δ ]]> Sample Group 1 252±0.015* 4.627±0.169* Sample Group 2 411±0.017** 4.685±0.212* Sample Group 3 495±0.039** 4.691±0.268* Sample Group 4 509±0.024** 4.718±0.268*

[0125] Δ =” represents P < 0.05 when comparing the model group with the blank group; * represents P < 0.01 when comparing the medication group with the model group; ** represents P < 0.05 when comparing the medication group with the model group.

[0126] In addition, it should be understood that after reading the above description of the present invention, those skilled in the art may make various changes or modifications to the present invention, and these equivalent forms also fall within the scope defined by the claims attached to this application.

[0127] Experimental Example 2: Far Infrared Detection

[0128] For Examples 1-6, a far-infrared sensor was used to capture absorption band data at 35±0.5°C, simulating human body temperature. The test results are as follows:

[0129] Table 3 Far infrared detection results

[0130]

[0131]

[0132] As can be seen from Table 3, the implementation of 1-3 can achieve the effective release of far-infrared wavelengths required by the human body, while although comparative examples 1-3 can also release far-infrared wavelengths, they cannot reach the optimal range of 8-15 μm required by the human body.

Claims

1. A nano-ion film patch, characterized by: The invention consists of component A and component B, wherein component A is composed of 20-40 parts of nano-ceramic particles, 10-20 parts of silane coupling agent, 5-7 parts of zirconium phosphate powder, 0.8-1.2 parts of natural copper powder and 30-50 parts of acetylene black powder according to weight parts; component B includes medical viscose cloth and release paper.

2. The nano-ion film patch according to claim 1, wherein: It consists of component A and component B, wherein component A is composed of 30 parts of nano-ceramic particles, 15 parts of silane coupling agent, 6 parts of zirconium phosphate powder, 1 part of natural copper powder, and 40 parts of acetylene black powder, calculated by weight; component B includes medical viscose tape and release paper.

3. The nano-ion film patch according to claim 1 or 2, characterized in that: The nano ceramic particles are powder with a particle size of 50-100 μm.

4. The nano-ion film patch according to claim 1 or 2, characterized in that: The particle size of the zirconium phosphate powder is 100-200 μm.

5. The nano-ion film patch according to claim 1 or 2, characterized in that: The particle size of the natural copper powder is 100-200 μm.

6. The nano-ion film patch according to claim 1 or 2, characterized in that: The particle size of the acetylene black powder is 50-100 μm.

7. The nano-ion film patch according to claim 1 or 2, characterized in that: The silane coupling agent is γ-aminopropyltriethoxysilane.

8. The method for preparing the nano-ion film patch according to any one of claims 1 to 7, characterized in that: The steps include: (1) Adding nano-ceramic particles to zirconium phosphate powder and natural copper powder, mixing and stirring for 30-60 minutes at a stirring rate of 1000-2000 r / min to obtain coupled metal ceramic particles, which are set aside; (2) adding acetylene black powder to the coupled metal ceramic particles, mixing and stirring for 25-35 minutes at a stirring rate of 1000-2000 r / min to obtain a coupled metal ceramic particle composite material for later use; (3) adding 95% ethanol to a silane coupling agent, stirring and hydrolyzing for 4-6 minutes to obtain a γ-aminopropyltriethoxysilane solution with a concentration of 2-3%, adding the coupled metal ceramic particle composite material, stirring evenly, and then placing it in a microwave oven and treating it at a microwave power of 80-120 W for 2-3 minutes to obtain a nano-ion film substrate; (4) The medical viscose cloth is used as the lower layer, the middle layer is the nano-ion film, and the nano-ion film substrate is coated in the middle of the medical viscose cloth. The substrate amount is 500-1000 g / m 2 , and the upper layer is covered with release paper to obtain the nano ion film patch.

9. The method for preparing the nano-ion film patch according to claim 8, wherein: The steps include: (1) Adding nano-ceramic particles to zirconium phosphate powder and natural copper powder, mixing and stirring for 45 minutes at a stirring rate of 1500 r / min to obtain coupled metal ceramic particles, which are set aside; (2) adding acetylene black powder to the coupled metal ceramic particles, mixing and stirring for 30 minutes at a stirring rate of 1500 r / min to obtain a coupled metal ceramic particle composite material for later use; (3) Add 95% ethanol to the silane coupling agent, stir and hydrolyze for 5 minutes to obtain a 2.5% silane coupling agent solution, add the coupled metal ceramic particle composite material, stir evenly, and then place it in a microwave oven and treat it at a microwave power of 100 W for 2.5 minutes to obtain a nano-ion film substrate; (4) Coat the nano-ion film substrate in the middle of the medical viscose cloth, with the substrate amount being 500-1000 g / m 2 , both the top and bottom are covered with release paper to effectively isolate the nano-ion film patch.

10. The use of the nano-ion film patch according to claim 1 for treating and inhibiting uterine fibroids, characterized in that: The nano-ion film patch can be used to treat uterine fibroids and inhibit the recurrence of uterine fibroids.

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